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KAIST

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Center+for+cell-encapsulation+research

Artificial Spore Production Technology Developed The core technology needed in the development of ‘biosensors’ so crucial in diagnosing illnesses or pathogens was developed by Korean research team. KAIST’s Professor Choi In Seung of the department of Chemistry developed the technology that allows for the production of Artificial Spore by selectively coating a live cell. In the field of engineering the problem in developing the next generation bio sensor, the cell based sensor, was that it was difficult to keep a cell alive without division for a long time. Once a cell is taken out of the body, it will either divide or die easily. Professor Choi’s research team mimicked the spore, which has the capability to survive harsh conditions without division, and chemically coated a live cell and artificially created a cell similar to that of a spore. The physical and biological stabilities of the cell increased by coating an artificial shell over the yeast cell. The shell is composed with a protein similar to that of the protein that gives mussels its stickiness. In addition by controlling the thickness of the shell, the division rate of the yeast can be controlled. Professor Choi commented that this technology will serve as the basis for the single cell based biosensor. The research was conducted together with Professor Lee Hae Shin of KAIST department of Chemistry and Professor Jeong Taek Dong of Seoul National University’s department of Chemistry and was published as the cover paper of ‘Journal of the American Chemical Society’.
2011.04.01 View 11875

KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea T.042-350-2114 F.042-350-2210(2220)