bone+bandage
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KAIST develops a new, bone-like material that strengthens with use in collaboration with GIT
Materials used in apartment buildings, vehicles, and other structures deteriorate over time under repeated loads, leading to failure and breakage. A joint research team from Korea and the United States has successfully developed a bioinspired material that becomes stronger with use, taking inspiration from the way bones synthesize minerals from bodily fluids under stress, increasing bone density.
< (From left) Professor Sung Hoon Kang of the Department of Materials Science and Engineering, Johns Hopkins University Ph.D. candidates Bohan Sun and Grant Kitchen, Professor Yuhang Hu and Ph.D. candidate Dongjung He of Georgia Institute of Technology >
KAIST (represented by President Kwang Hyung Lee) announced on the 20th of February that a research team led by Professor Sung Hoon Kang from the Department of Materials Science and Engineering, in collaboration with Johns Hopkins University and the Georgia Institute of Technology, had developed a new material that strengthens with repeated use, similar to how bones become stronger with exercise.
Professor Kang’s team sought to address the issue of conventional materials degrading with repeated use. Inspired by the biological process where stress triggers cells to form minerals that strengthen bones, the team developed a material that synthesizes minerals under stress without relying on cellular activity. This innovation is expected to enable applications in a variety of fields.
To replace the function of cells, the research team created a porous piezoelectric substrate that converts mechanical force into electricity and actually generates more charge under greater force. They then synthesized a composite material by infusing it with an electrolyte containing mineral components similar to those in blood.
< Figure 1. Schematic diagram of the biomimetic concept based on bone and pitcher plants, the reversible strengthening mechanism, the process of fabricating porous composites, the mechanical property changes with increasing stiffness and energy dissipation after cyclic loading, and the reprogrammable self-folding mechanism and applications >
After subjecting the material to periodic forces and measuring changes in its properties, they observed that its stiffness increased proportionally with the frequency and magnitude of stress and that its energy dissipation capability improved.
The reason for such properties was found to be due to minerals forming inside the porous material under repeated stress, as observed through micro-CT imaging of its internal structure. When subjected to large forces, these minerals fractured and dissipated energy, only to reform under further cyclic stress.
Unlike conventional materials that weaken with repeated use, this new material simultaneously enhances stiffness and impact absorption over time.
< Figure 2. Comparison of the changes in properties of the newly developed new material (LIPPS) with other materials under cyclic loading. (A) Graph showing the relative change rate of energy dissipation after cyclic loading and the relative change rate of elastic modulus upon unloading. LIPPS is in a new area that existing materials have not reached, and shows the characteristics of simultaneous increases in elastic modulus and energy dissipation. (B) Graph comparing the performance of LIPPS with current state-of-the-art mechanically adaptive materials. (Left) The maximum property change rate compared to the baseline after cyclic loading, LIPPS shows much higher changes in elastic modulus, dissipated energy density and ratio, toughness (impact resistance), and stored energy density than the existing adaptive materials. (Right) The absolute value range of the reported properties before and after cyclic loading shows that LIPPS has higher elastic modulus and toughness than the existing adaptive materials. >
Moreover, because its properties improve in proportion to the magnitude and frequency of applied stress, it can self-adjust to achieve mechanical property distributions suitable for different structural applications. It also possesses self-healing capabilities.
Professor Kang stated, "This newly developed material, which strengthens and absorbs impact better with repeated use compared to conventional materials, holds great potential for applications in artificial joints, as well as in aircraft, ships, automobiles, and structural engineering."
This study, with Professor Sung Hoon Kang as the corresponding author, was published in Science Advances (Vol. 11, Issue 6, February).
(Paper title: “A material dynamically enhancing both load-bearing and energy-dissipation capability under cyclic loading”) DOI: 10.1126/sciadv.adt3979
This research was conducted as a joint effort with Johns Hopkins University's Extreme Materials Institute and the Georgia Institute of Technology, supported by the National Research Foundation of Korea’s Brain Pool Plus program.
2025.02.22 View 395 -
A KAIST Research Team Develops a Novel “Bone Bandage” Material for Cracked Bones
Bone regeneration is a complex process, and existing methods to aid regeneration including transplants and growth factor transmissions face limitations such as the high cost. But recently, a piezoelectric material that can promote the growth of bone tissue has been developed.
A KAIST research team led by Professor Seungbum Hong from the Department of Materials Science and Engineering (DMSE) announced on January 25 the development of a biomimetic scaffold that generates electrical signals upon the application of pressure by utilizing the unique osteogenic ability of hydroxyapatite (HAp). This research was conducted in collaboration with a team led by Professor Jangho Kim from the Department of Convergence Biosystems Engineering at Chonnam National University.
HAp is a basic calcium phosphate material found in bones and teeth. This biocompatible mineral substance is also known to prevent tooth decay and is often used in toothpaste.
Previous studies on piezoelectric scaffolds confirmed the effects of piezoelectricity on promoting bone regeneration and improving bone fusion in various polymer-based materials, but were limited in simulating the complex cellular environment required for optimal bone tissue regeneration. However, this research suggests a new method for utilizing the unique osteogenic abilities of HAp to develop a material that mimics the environment for bone tissue in a living body.
< Figure 1. Design and characterization of piezoelectrically and topographically originated biomimetic scaffolds. (a) Schematic representation of the enhanced bone regeneration mechanism through electrical and topographical cues provided by HAp-incorporated P(VDF-TrFE) scaffolds. (b) Schematic diagram of the fabrication process. >
The research team developed a manufacturing process that fuses HAp with a polymer film. The flexible and free-standing scaffold developed through this process demonstrated its remarkable potential for promoting bone regeneration through in-vitro and in-vivo experiments in rats.
The team also identified the principles of bone regeneration that their scaffold is based on. Using atomic force microscopy (AFM), they analysed the electrical properties of the scaffold and evaluated the detailed surface properties related to cell shape and cell skeletal protein formation. They also investigated the effects of piezoelectricity and surface properties on the expression of growth factors.
Professor Hong from KAIST’s DMSE said, “We have developed a HAp-based piezoelectric composite material that can act like a ‘bone bandage’ through its ability to accelerate bone regeneration.” He added, “This research not only suggests a new direction for designing biomaterials, but is also significant in having explored the effects of piezoelectricity and surface properties on bone regeneration.”
This research, conducted by co-first authors Soyun Joo and Soyeon Kim from Professor Hong’s group, was published on ACS Applied Materials & Interfaces on January 4 under the title “Piezoelectrically and Topographically Engineered Scaffolds for Accelerating Bone Regeneration”. From Professor Kim’s group, Ph.D. candidate Yonghyun Gwon also participated as co-first author, and Professor Kim himself as a corresponding author.
< Figure 2. Analysis of piezoelectric and surface properties of the biomimetic scaffolds using atomic force microscopy. (a) PFM amplitude and phase images of box-poled composite scaffolds. The white bar represents 2 μm. (b) 3D representations of composite scaffolds paired with typical 2D line sections. (c) In vivo bone regeneration micro-CT analysis, (d) schematic representation of filler-derived electrical origins in bone regeneration. >
This research was supported by the KAIST Research and Development Team, the KUSTAR-KAIST Joint Research Center, the KAIST Global Singularity Project, and the government-funded Basic Research Project by the National Research Foundation of Korea.
2024.02.01 View 5755