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Maximum Yield Amino Acid-Producing Microorganism Developed with use of System Biotechnology
Maximum Yield Amino Acid-Producing Microorganism Developed with use of System Biotechnology
A team led by Sang-Yup Lee, a distinguished professor of Chemical and Biomolecular Engineering and chair professor of LG Chemical, has succeeded in developing maximum yield L-valine-producing microorganism by using System Biotechnology methods. The research results will be published at the April fourth week (April 23 - 27) edition of the Proceedings of the National Academy of Sciences (PNAS) of the USA.
Prof. Lee’s team has developed maximum yield amino acid-producing microorganism (target substance of L-valine, an essential amino-acid) by using microorganism E cell system and simulation methods.
His team produced initial producing microorganism by selectively operating necessary parts in colon bacillus genome and excavated preliminary target gene which is to newly be operated through transcriptome analysis using DNA chips. Then they performed a great amount of gene deletion experiment on computer by using MBEL979, E-cells of colon bacillus, and excavated secondary engineering targets. And they finally succeeded in developing maximum yield valine-producing microorganism that can extract 37.8 grams of valine from 100 grams of glucose by applying experiment results to the actual development of microorganism so as to achieve the optimization of metabolic flux in cells,
Prof. Lee said, “Since successfully used for the development of microorganism on a systematic system level, system biotechnology methods are expected to significantly contribute to the development of all biotechnology-relevant industries. At the beginning, we had huge obstacles in fusing IT and BT, but my team mates cleverly overcame such obstacles, hence I’m very proud of them.” The producing microorganism and its developing methods are pending international applications (PCT).
2007.04.26 View 14991 -
A doctorate of Mechanical Engineering Named Recipient of Best Student Paper Award at International Society
Seung-Min Ryu, a doctorate of Mechanical Engineering under the supervision of Professor Dong-Yul Yang, has been named as a recipient of the best student paper award of the Society for Information Display (SID).
The title of the paper is ‘the study on the fabrication of super-high resolution cathode separators by X-ray lithography processes’. He proposed at this paper the fabrication of 12 micron-thick cathode separators, which can fabricate further delicate separators than the current 50 micron-thick commercial PDP separators, thereby significantly improving the resolution of PDPs in the future.
Ryu will make an oral presentation on this paper and win the award at the SID conference, which will take place in the U.S. for six days from May 20.
2007.04.23 View 15607 -
Gold prize for Sungkoo Yeo and silver prize for Youngsik Kim at 'Samsung Electrics paper contest'
Gold prize for Sungkoo Yeo and silver prize for Youngsik Kim at ‘Samsung Electrics paper contest’
Sungkoo Yeo, doctorate student at the division of Electrical Engineering, and Youngsik Kim, doctorate students at the division of Mechanical Engineering, won gold and silver prizes respectively at ‘the 2nd Inside edge paper contest’ organized by Samsung Electronics.
Yeo, under the supervisory of Professor Youngse Kwon, won the glory of gold prize in recognition of his highly evaluated researches in the fields of silicon-based micro mold manufacturing technologies and fine shaping technologies revealed by his paper of ‘"Fabrication of Microlens array Using PDMS Replica Molding and Oxidized Porous Silicon Bulk Micromachining’.
Kim, under the supervisory of Professor Seungwoo Kim, also won the silver prize for his research performances over the thickness pattern measuring technologies of transparent thin film coated on the pattern of an opaque metal in the field of optical technology unveiled by his paper of "Dispersive white-light interferometry for in-line inspection of thin-film layers on patterned structures".
Inside Edge paper contest is an academic paper contest organized by Samsung Electronics to reveal the fresh ideas and potential technologies of the young talented.
2006.11.27 View 17030