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Bioengineers develop a new strategy for accurate prediction of cellular metabolic fluxes
A team of pioneering South Korean scientists has developed a new strategy for accurately predicting cellular metabolic fluxes under various genotypic and environmental conditions. This groundbreaking research is published in the journal Proceedings of the National Academy of Sciences of the USA (PNAS) on August 2, 2010.
To understand cellular metabolism and predict its metabolic capability at systems-level, systems biological analysis by modeling and simulation of metabolic network plays an important role. The team from the Korea Advanced Institute of Science and Technology (KAIST), led by Distinguished Professor Sang Yup Lee, focused their research on the development of a new strategy for more accurate prediction of cellular metabolism.
“For strain improvement, biologists have made every effort to understand the global picture of biological systems and investigate the changes of all metabolic fluxes of the system under changing genotypic and environmental conditions,” said Lee. The accumulation of omics data, including genome, transcriptome, proteome, metabolome, and fluxome, provides an opportunity to understand the cellular physiology and metabolic characteristics at systems-level. With the availability of the fully annotated genome sequence, the genome-scale in silico (means “performed on computer or via computer simulation.”) metabolic models for a number of organisms have been successfully developed to improve our understanding on these biological systems. With these advances, the development of new simulation methods to analyze and integrate systematically large amounts of biological data and predict cellular metabolic capability for systems biological analysis is important.
Information used to reconstruct the genome-scale in silico cell is not yet complete, which can make the simulation results different from the physiological performances of the real cell. Thus, additional information and procedures, such as providing additional constraints (constraint: a term to exclude incorrect metabolic fluxes by restricting the solution space of in silico cell) to the model, are often incorporated to improve the accuracy of the in silico cell.
By employing information generated from the genome sequence and annotation, the KAIST team developed a new set of constraints, called Grouping Reaction (GR) constraints, to accurately predict metabolic fluxes. Based on the genomic information, functionally related reactions were organized into different groups. These groups were considered for the generation of GR constraints, as condition- and objective function- independent constraints. Since the method developed in this study does not require complex information but only the genome sequence and annotation, this strategy can be applied to any organism with a completely annotated genome sequence.
“As we become increasingly concerned with environmental problems and the limits of fossil resources, bio-based production of chemicals from renewable biomass has been receiving great attention. Systems biological analysis by modeling and simulation of biological systems, to understand cellular metabolism and identify the targets for the strain improvement, has provided a new paradigm for developing successful bioprocesses,” concluded Lee. This new strategy for predicting cellular metabolism is expected to contribute to more accurate determination of cellular metabolic characteristics, and consequently to the development of metabolic engineering strategies for the efficient production of important industrial products and identification of new drug targets in pathogens.”
2010.08.05 View 12367 -
Native-like Spider Silk Produced in Metabolically Engineered Bacterium
Microscopic picture of 285 kilodalton recombinant spider silk fiber
Researchers have long envied spiders’ ability to manufacture silk that is light-weighted while as strong and tough as steel or Kevlar. Indeed, finer than human hair, five times stronger by weight than steel, and three times tougher than the top quality man-made fiber Kevlar, spider dragline silk is an ideal material for numerous applications. Suggested industrial applications have ranged from parachute cords and protective clothing to composite materials in aircrafts. Also, many biomedical applications are envisioned due to its biocompatibility and biodegradability.
Unfortunately, natural dragline silk cannot be conveniently obtained by farming spiders because they are highly territorial and aggressive. To develop a more sustainable process, can scientists mass-produce artificial silk while maintaining the amazing properties of native silk? That is something Sang Yup Lee at the Korea Advanced Institute of Science and Technology (KAIST) in Daejeon, the Republic of Korea, and his collaborators, Professor Young Hwan Park at Seoul National University and Professor David Kaplan at Tufts University, wanted to figure out. Their method is very similar to what spiders essentially do: first, expression of recombinant silk proteins; second, making the soluble silk proteins into water-insoluble fibers through spinning.
For the successful expression of high molecular weight spider silk protein, Professor Lee and his colleagues pieced together the silk gene from chemically synthesized oligonucleotides, and then inserted it into the expression host (in this case, an industrially safe bacterium Escherichia coli which is normally found in our gut). Initially, the bacterium refused to the challenging task of producing high molecular weight spider silk protein due to the unique characteristics of the protein, such as extremely large size, repetitive nature of the protein structure, and biased abundance of a particular amino acid glycine. “To make E. coli synthesize this ultra high molecular weight (as big as 285 kilodalton) spider silk protein having highly repetitive amino acid sequence, we helped E. coli overcome the difficulties by systems metabolic engineering,” says Sang Yup Lee, Distinguished Professor of KAIST, who led this project. His team boosted the pool of glycyl-tRNA, the major building block of spider silk protein synthesis. “We could obtain appreciable expression of the 285 kilodalton spider silk protein, which is the largest recombinant silk protein ever produced in E. coli. That was really incredible.” says Dr. Xia.
But this was only step one. The KAIST team performed high-cell-density cultures for mass production of the recombinant spider silk protein. Then, the team developed a simple, easy to scale-up purification process for the recombinant spider silk protein. The purified spider silk protein could be spun into beautiful silk fiber. To study the mechanical properties of the artificial spider silk, the researchers determined tenacity, elongation, and Young’s modulus, the three critical mechanical parameters that represent a fiber’s strength, extensibility, and stiffness. Importantly, the artificial fiber displayed the tenacity, elongation, and Young’s modulus of 508 MPa, 15%, and 21 GPa, respectively, which are comparable to those of the native spider silk.
“We have offered an overall platform for mass production of native-like spider dragline silk. This platform would enable us to have broader industrial and biomedical applications for spider silk. Moreover, many other silk-like biomaterials such as elastin, collagen, byssus, resilin, and other repetitive proteins have similar features to spider silk protein. Thus, our platform should also be useful for their efficient bio-based production and applications,” concludes Professor Lee.
This work is published on July 26 in the Proceedings of the National Academy of Sciences (PNAS) online.
2010.07.28 View 16764 -
Professor Thompson
Professor Mary Kathryn Thompson of Civil and Environmental Engineering Department wrote her regular column on correlation between art and engineering, “Engineers, Artists Not on Opposite Ends.” The column was published by the Korea Herald on July 23, 2010. For reading, please click the link below.
http://www.koreaherald.com/opinion/Detail.jsp?newsMLId=20100722000548
2010.07.23 View 9548 -
The thermal fluctuation and elasticity of cell membranes, lipid vesicles, interacting with pore-forming peptides were reported by a research team at KAIST.
A research team from KAIST, consisted of Sung-Min Choi, Professor of Nuclear and Quantum Engineering Department, and Ji-Hwan Lee, a doctoral student in the Department, published a paper on the “thermal fluctuation and elasticity of lipid vesicles interacting with pore-forming peptides.” The paper was carried by Physical Review Letters, an internationally renowned peer-review journal on physics on July 16, 2010.
Cell membranes, which consist of lipid bilayers, play important roles in cells as barriers to maintain concentrations and matrices to host membrane proteins. During cellular processes such as cell fission and fusion, the cell membranes undergo various morphological changes governed by the interplay between protein and lipid membranes. There have been many theoretical and experimental approaches to understand cellular processes driven by protein-lipid membrane interactions. However, it is not fully established how the membrane elastic properties, which play an important role in membrane deformation, are affected by the protein-membrane interactions.
Antimicrobial peptides are one of the most common examples of proteins that modify membrane morphology. While the pore-forming mechanisms of antimicrobial peptides in lipid bilayers have been widely investigated, there have been only a few attempts to understand the mechanisms in terms of membrane elastic properties. In particular, the effects of pore formation on the membrane fluctuation and elastic properties, which provide key information to understand the mechanism of antimicrobial peptide activity, have not been reported yet. The research team reports the thermal fluctuation and elasticity of lipid vesicles interacting with pore-forming peptides, which were measured by neutron spin-echo spectroscopy.
The results of this study are expected to pay an important role in understanding the elastic behavior and morphological changes of cell membranes induced by protein-membrane interactions, and may provide new insights for developing new theoretical models for membrane fluctuations which include the membrane mediated interaction between protein patches.
(a) (b)
Figure
(a) Schematics for bound melittin and pores in lipid bilayers
(b) P NMR signal ratio (with/without Mn2+) of DOPC LUV-melittin vs P/L at 30˚C. The dashed line is a guide for eyes.
2010.07.23 View 11239 -
A stream of generous donations to KAIST continues to grow.
Yi-Won Oh is nothing but an ordinary person who lives in Seoul. Ever since retirement, she has looked into ways to donate her savings for a bigger cause that will benefit the people in need and the nation as a whole.
On the inauguration day of President Nam Pyo Suh who took his second term in office, Ms. Oh joined the ceremony and pledged to donate her savings to KAIST, which amounted to 10 billion won.
“I’ve always thought that the best way for our country to become a developed nation that lacks natural resources and has a small land is to develop science and technology by producing excellent manpower through a quality education. I talked to President Suh a couple of times, and we shared our common belief that the future of our nation hinges on the advancement of science and technology in Korea,” said Ms. Oh.
She added, “I support for President Suh’s vision and leadership, who has brought reformative and innovative changes to KAIST. I have no doubt that KAIST will become a leading research university in the world and play an important role in the development of our nation. It is indeed my pleasure that I can make announcement to donate my money to KAIST on the day President Suh is assigned to lead such a distinguished university one more time.”
KAIST plans to create and operate a fund dubbed “Yi-Won Oh Scholarship and Grant for Young Chair Professors.” Through the fund, talented students suffering financial difficulties and promising, young professors will have a richer opportunity to study and research.
2010.07.21 View 9252 -
International Center was built to promote greater exchanges and collaborations between the international community and KAIST.
On July 9, 2010, KAIST held an opening ceremony for the construction of International Center. The Center will serve as an internal and external liaison for the university, providing a source of assistance to faculty, administrators, and students on matters related to international activities and initiatives. It will also pursue greater exchanges and collaborations between the international community and KAIST.
The facility accommodates various meetings, exhibitions, library, language services, and other amenities. The International Cooperation Team of KAIST will be moved into this building and provide a variety of services, such as immigration regulations, cultural adjustment, employment, to assist international students, scholars, faculty, and staff at KAIST, as well as Korean students seeking opportunities to study, work, or travel abroad. An international nursery school will also be inside the building so that foreign faculty and students with children can have convenience and quality child care while they are teaching or studying.
At the center will be held many different kinds of international event—one among them is KAIST-ONE, a festival held twice a year in spring and fall to introduce and share culture, education, and food of the global community at KAIST.
2010.07.19 View 10839 -
A new facility at KAIST opened on July 6, 2010.
Ryu Geun-Chul Sports Complelx will allow students, faculty and staff to pause a moment and exhale in the hustle and bustle of their daily lives.
An opening ceremony celebrating the completion of a new facility for the KAIST family was held on July 6, 2010 at the campus. Had it not been for contributions of many people and organizations throughout the nation, among others, Dr. Geun-Chul Ryu, POSCO, Woori Bank, members of KAIST community, parents, and other citizens, it would be impossible to build the facility, said the university.
The Complex, a three-story building with a basement, has an indoor court for basketball and volleyball with 3,000 individual seats, 200 meters of running track, indoor golf range, a fitness center, and other convenient facilities.
Any members of KAIST community can visit the building and relax their body and mind stressed with work and study. It also provides a large space for ceremonial and cultural gatherings such as 2010 KAIST commencement ceremony.
The official name of the building is “Ryu Geun-Chul Sports Complelx,” which was created in appreciation of Dr. Geun-Chul Ryu’s generous act who had donated 57.8 billion won worth of real estate to KAIST in August 2008.
2010.07.07 View 11965 -
The 8th International Conference on Metabolic Engineering was held on June 13-18, 2010 in Jeju Island, South Korea.
From left to right, top row: Distinguished Professor and the conference chair Sang Yup Lee, Sang-Hyup Kim - Secretary to the President of Korea, Dr. Jay Keasling, Dr. Greg Stephanopoulos. Left to right, bottom row: Dr. William Provine, Dr. Terry Papoutsakis, Dr, Jens Nielsen, Dr. Lars Nielsen.
The importance of industrial biotechnology that produces chemicals and materials from renewable biomass is increasing due to climate change and the dearth of natural resources. Industrial biotechnology refers to a technology that allows sustainable bio-based production of chemicals and materials that could enrich human"s lives using microorganisms. This is where metabolic engineering comes into play for successful application of microorganisms, in which they are engineered in our intended way for improved production capability.
The 8th International Conference on Metabolic Engineering, the longest running conference of its kind, was held on June 13-18, 2010 at the International Convention Center in Jeju Island, South Korea. Distinguished Professor Sang Yup Lee of KAIST, Dean of College of Life Science and Bioengineering and Co-Director of Institute for the BioCentury, chaired the conference with the main theme of "metabolic engineering for green growth."
With 300 delegates selected by the committee, papers on production of biofuels, chemicals, biopolymers, and pharmaceutics and the development of fundamental metabolic engineering techniques were presented at the conference along with examples of successful commercialization of products developed by several global companies.
Sang Hyup Kim, Secretary to the President of Korea, gave an opening plenary lecture entitled "Korean green growth initiative," to inform experts from around the globe of the leadership on green growth in Korea. Young Hoon Park, President of Korea Research Institute of Bioscience and Biotechnology (KRIBB, Korea) delivered his congratulatory address.
Sang Hyup Kim said, "Hosting an international conference in Korea on metabolic engineering, which forms a core technology necessary for the development of environmentally friendly processes for producing chemicals and biofuels from renewable biomass, is very meaningful as green growth is a big issue around the globe. This is a great chance to show the excellence of Korea"s green growth associated technology to experts in metabolic engineering and industrial biotechnology."
A total of 47 invited lectures in this conference included recent and important topics, for instance, "Synthetic biology for synthetic fuels" by Dr. Jay Keasling from the Joint BioEnergy Institute (USA), "Microbial oil production from renewable feedstocks" by Dr. Greg Stephanopoulos from MIT (USA), "Yeast as a platform cell factory for production of fuels and chemicals" by Dr. Jens Nielsen from Chalmers University (Sweden), "Mammalian synthetic biology - from tools to therapies" by Dr. Martin Fussengger from ETH (Switzerland), "Building, modeling, and applications of metabolic and transcriptional regulatory networks at a genome-scale" by Dr. Bernhard Palsson from the University of California - San Diego (USA), "Genome analysis and engineering Eschericha coli for sucrose utilization" by Dr. Lars Nielsen from the University of Queensland (Australia), "Artificial microorganisms by synthetic biology" by Dr. Daniel Gibson from JCVI (USA), and "Metabolomics and its applications" by Dr. Masaru Tomita from Keio University (Japan). From Korea, Dr. Jin Hwan Park from the research group of Dr. Sang Yup Lee at KAIST presented "Systems metabolic engineering of Escherichia coli for amino acid production," and Dr. Ji Hyun Kim from KRIBB presented "Genome sequencing and omics systems analysis of the protein cell factory of Escherichia coli".
Global companies involved in biorefinery presented their recent research outcomes with emphasis on commercialized technologies. They included "Metabolic and process engineering for commercial outcomes" by Dr. William Provine from DuPont (USA), "Direct production of 1,4-butanediol from renewable feedstocks" by Dr. Mark Burk from Genomatica (USA), "Development of an economically sustainable bioprocess for the production of bio 1,2-propanediol" by Dr. Francis Voelker from Metabolic Explorer (France), "Biotechnology to the bottom-line: low pH lactic acid production at industrial scale" by Dr. Pirkko Suominen from Cargill (USA), "Bioisoprene™: traditional monomer, traditional chemistry, sustainable source" by Dr. Gregg Whited from Danisco (USA) and "Efficient production of pharmaceuticals by engineered fungi" by Dr. Roel Bovenberg from DSM (Netherlands).
This biennial conference also presented the International Metabolic Engineering Award (expanded version of the previous Merck Metabolic Engineering Award) to the best metabolic engineer in the world. The 2010 International Metabolic Engineering Award went to Dr. E. Terry Papoutsakis from the University of Delaware (USA) who has contributed to the production of biobutanol through the metabolic engineering of Clostridia in the last three decades, and he gave an award lecture. Dr. Sang Yup Lee, the current chair of the upcoming conference, was the previous recipient of this award at the last metabolic engineering conference in 2008.
In addition to the invited lectures, a total of 156 carefully selected poster papers were chosen for presentation, and awards were presented to the best posters after rigorous review by the committee members. Such awards included "The 2010 Metabolic Engineering Best Poster Award" and the "2010 Young Metabolic Engineer Award" from the Metabolic Engineering conference, and prestigious international journal awards, including "Wiley Biotechnology Journal Best Poster Award", "Wiley Biotechnology and Bioengineering Best Poster Award" and "Elsevier Metabolic Engineering Best Paper Award." Dr. Catherine Goodman, a senior editor of Nature Chemical Biology, also presented the "Nature Chemical Biology Best Poster Award on Metabolic Engineering."
Regarding this conference, Dr. Sang Yup Lee, the conference chair, said, "This conference is the best international conference in the field of metabolic engineering, which is held every two years, and Korea is the first Asian country to host it. All the experts and students spend time together from early breakfast to late poster sessions, which is a distinct feature of this conference. Although the number of delegates had typically been limited to 200, around 300 delegates were selected this year to accept more attendees from many people who have been interested in metabolic engineering. Also, it is very fitting that "green growth" is the main topic of this conference because Korea is playing a key role in this field. I"m grateful to the Lotte Scholarship Foundation, COFCO, GS Caltex, Bioneer, US DOE, US NSF, Daesang, CJ Cheiljedang, Genomatica and DuPont who provided us with generous financial support that allowed the successful organization of this conference."
The conference was organized by the Systems Biology Research Project Team supported by the Ministry of Eduction, Science and Technology (MEST), Microbial Frontier Research Project Group, World Class University Project Group at KAIST, Institute for the BioCentury at KAIST, Korean Society for Biotechnology and Bioengineering, and the Engineering Conference International (ECI) of the United States.
Inquiries: Professor Sang Yup Lee (+82-42-350-3930), industrialbio@gmail.com
2010.06.25 View 17856 -
President of Israel visited KAIST on June 9, 2010.
President of Israel, Shimon Peres, visited KAIST today on June 9, 2010 to witness the development of science and technology in Korea and explore ways of establishing collaboration and cooperation with industries and universities between Korea and Israel. President Peres led a delegation consisted of the Israeli Mister of Industry, Trade, and Labor, the Minister of Communication, and 60 business leaders from the top companies in the security, infrastructure, communication, high-tech, and water industries.
Upon their arrival to the campus, the Israeli delegation was greeted by KAIST’s humanoid robot, “HUBO,” and then moved to its branch campus, IT Convergence Campus, for a ride of Online Electric Vehicle (OLEV) that has been developed by KAIST. The OLEV receives the necessary power through the cable lines buried underground, so it can be provided with a constant and continuous supply of electricity while running or stopping.
Between roads and OLEVs is nothing but space. There is no electrical wires intricately crossed underbody of the electric car or above the road. The pick-up equipment installed beneath the body of the electric car collects magnetic fields created around the underground cables, which then converts the filed into electricity. The OLEV’s wireless, non-contact charging system made it possible for a battery currently used for hybrid or pure electric cars on the market to be smaller and cheaper.
President Peres expressed a great interest in the technology applied to the OLVE, quoting, “the OLEV system is indeed very impressive.” He talked about efforts being made in Israel with respect to the development of electric cars. The country plans to replace the conventional transportation system with electric cars by constructing a network of battery exchange stations and roadside charge points which allow the cars to be charged whenever they are parked.
“Despite the different approach taken by the two nations for the development of electric cars, I believe that transforming the automobile industry from combustion engine to electric system is the right direction we should all follow. Without addressing the current transportation system that heavily dependent on natural resources, we will not be able to promote “green growth on a global scale,” added President Peres.
In addition to electric cars, President Peres took up a considerable portion of his time to exchange ideas on how to expand cooperative relations between universities in Korea and Israel, specifically in the area of space, biotechnology, nanotechnology, high-tech, renewable and alternative energy, and the EEWS initiatives that have been implemented by KAIST to find answers to global issues such as climate change and depletion of natural resources. The EEWS stands for energy, environment, water, and sustainability.
In response, the president of KAIST pledged to set up a stronger and greater tie with research universities in Israel, particularly called for more collaboration between KAIST and Technion-Israel Institute of Technology.
Also, the Israeli delegation had a tour for several Korean research and development centers in Daedeok Innopolis, located in the City of Daejeon, which is the 2nd largest science and research complex in Korea.
Shimon Peres, the 9th president of Israel, held many of important government positions in Israel, among other things, Prime Minster and Minister of Defense. He won Nobel Peace Prize in 1994, together with Yitzhak Rabin and Yasser Arafat for the conclusion of a peace agreement, Oslo Accords, between Israel and Palestine Liberation Organization.
2010.06.09 View 15111 -
KAIST held an opening ceremony for the completion of KAIST Institute Building.
A Korean American businessman and his wife, Byiung Jun Park and Chunghi Hong, donated 10 million USD for the construction of the building.
KAIST hosted an opening ceremony on May 11, 2010 for the new addition to its campus, called the Chunghi & Byiung Jun (BJ) Park KAIST Institute Building. The KI Building will serve as a hub for creative multidisciplinary researches.
A Korean American businessman and his wife made a considerable contribution for the construction of the building, worth 10 million USD. KAIST called the building Byiung Jun (BJ) Park and Chunghi Hong in recognition of their contribution. Chairman Park was the founder of the Merchandise Testing Laboratory, a leading textile quality control multinational.
It took 19 months to finish the construction of the KI Building with a total cost of 36 billion Korean won. The building consists of one basement and five ground floors. At the basement, there are clean room and equipment storage room; on the 2nd and 3rd floors, conference and exhibition halls; and on the rest of the floors, research labs and administration offices are to be located.
KAIST’s eight integral research institutes will be placed inside the building: the BioCentury; Information Technology Convergence; Design of Complex Systems; Entertainment Engineering; the NanoCentury; Eco-Energy; Urban Space and Systems; and Optical Science and Technology. Approximately 230 professors from 25 departments of various academic fields will make the KI Building home for study and research. The KI Building will play a great role in producing world-class convergence research works by KAIST researchers and professors, thereby making a contribution to the improvement of national competitiveness.
Vice President of KI Building, Sang-Soo Kim, said, “There has been no such place for us to concentrate research manpower and equipment scattered around the campus. By having all the necessary resources at one place will allow us to conduct convergence researches more efficiently and effectively. I’d like to express my appreciation for the Ministry of Education and Science and Technology as well as Chairman Byiung Jun (BJ) Park, who gave us tremendous supports in the process of constructing the KI Building.”
“The building’s inside has a unique office structure, getting rid of walls or partitions between institutes or departments, to stimulate an environment conducive to convergence researches. We hope to present a new model for creative multidisciplinary researches through a selective and focused approach to be facilitated by institutes at the KI Building,” added by the vice president.
2010.05.20 View 11783 -
The 6th president of KAIST passed away on May 7, 2010.
Dr. Sang-Soo Lee was the first president of Korea Advanced Institute of Science (KAIS) and the 6th president of KAIST, who died of a chronic disease at the age of 85. The KAIS was the matrix of KAIST today. Graduated from the physics department of Seoul National University in 1949, he later received a doctoral degree in optics from Imperial College of Science and Technology, University of London.
Dr. Lee has greatly contributed to the development of science and technology in Korea in the capacity of a policy administrator, educator, scientist, researcher, and engineer. He held numerous prestigious offices including President of Korea Atomic Energy Research Institute in 1967, of KAIS in 172, and of KAIST in 1989. Dr. Lee also worked as a professor at the physics department of KAIST for 20 years from 1972-1992.
The Society of Photographic Instrumentation Engineers (SPIE), an international society for optics and photonics, was founded in 1955 to advance light-based technologies. Dr. Sang-Soo Lee was a member of the SPIE that issued a news release expressing its sincere condolences to his death. The following is the full text of the news release: http://spie.org/x40527.xml
In memoriam: Sang Soo Lee
10 May 2010
Sang Soo Lee, known as the "Father of Optics" in Korea passed away on May 7, 2010, in Korea. He was 84.
Lee received a B.S. in Physics from Seoul National University in Korea and a Ph.D. from Imperial College of Science and Technology, University of London, UK. Receiving the first Ph.D. in Optics in Korea, Dr. Lee devoted his life to lay the foundation for optical science and engineering for more than four decades as an educator, researcher, and administrator in science policy.
"He was one of the architects of the extraordinary and rapid emergence of Korea as a world leader in science and technology, or perhaps with the rich history of contributions centuries ago, re-emergence would be more appropriate." said Eugene G. Arthurs, SPIE Executive Director.
During his teaching career, Dr. Lee mentored 50 doctoral and more than 100 masters" degree candidates. in the areas of laser physics, wave optics, and quantum optics. Many of his former students have become leaders in academia, government-funded research institutes, and industry both in Korea and abroad. He published more than 250 technical papers and authored five textbooks, including "Wave Optics", "Geometrical Optics", "Quantum Optics", and "Laser Speckles and Holography".
Lee was the first president of the Korea Advanced Institute of Science and Technology (KAIST), and the first president to establish a new government funded graduate school. He played a pivotal role in founding the Optical Society of Korea (OSK) in 1989 and served as its first president.
Lee was an active member of the international scientific community. In addition to his pioneering scholastic achievements at KAIST, he served as the Vice President of the International Commission for Optics (ICO), a Council Member of the Third World Academy of Sciences, and a Council Member of UN University, serving as an ambassador for the optics community, which showed a significant example of how a developing country like Korea can serve international optics community.
Dr. Lee was a Fellow of the International Society for Optical Engineering (SPIE), the Optical Society of America (OSA), and the Korean Physical Society (KPS). He was the recipient of many awards and honors, including the National Order of Civil Merit that is the Presidential Medal of Honor from the Republic of Korea (2000), the Songgok Academic Achievement Prize, the Presidential Award for Science, and the Medal of Honor for Distinguished Scientific Achievement in Korea. In 2006, he was awarded OSA"s Esther Hoffman Beller Medal.
2010.05.19 View 12803 -
New director of National Nano Fab Center was named.
Professor Ki-Ro Lee from the Electrical Engineering Department of KAIST has been appointed as the new Director of National Nano Fab Center, an affiliated institute to KAIST and will serve the position for three years beginning from May 4, 2010.
Director Lee graduated from Seoul National University in 1976 and received his doctoral degree from University of Minnesota, Twincities, the US, in 1983. He has taught at the Electrical Engineering Department since 1986. While at KAIST, he served as the dean of research affairs from 1998-200 and 2004-2005, respectively. From 2005 to 2007, he worked as the Director of LG Advanced Institute of Technology.
2010.05.19 View 10437