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New Bio-Clock gene and its function found
The Ministry of Education, Science and Technology announced that a Korean research team has found a new gene responsible for maintaining the bio-clock (twenty-four) and its mechanism.
Twnety-four was led by Professor Choi Joon Ho and Dr. Lee Jong Bin of KAIST (department of Biology) and was a joint operation with Professor Ravi Allada and Dr.Lim Jeong Hoon of Northwestern University (department of neurobiology) and the result was published in ‘Nature’ magazine.
The research team experimented with transformed small fruit flies for 4 years and found that there was an undiscovered gene that deals with the bio rhythm in the brain which they named ‘twenty-four’.
The understanding with genes prior to twenty-four was that these genes regulate biorhythm in the transcription phase (DNA to mRNA). Twenty-four operates in the step after transcription when the ribosome creates proteins. Especially twenty-four has a great effect on the ‘period protein’ which acts as a sub-atomic clock that regulates the rhythm and life of each cell.
The experiment was innovational in that it was able to scientifically prove the function of the protein produced by the gene.
The result is expected to help solve the problems associated with sleep disorders, jetlags, eating rhythms, bio rhythms, etc.
The name twenty-four was the fact that a day, a cycle, is 24 hours long and the gene’s serial numbers CG4857 adds up to twenty four.
2011.02.23 View 12328 -
Professor Min Beom Ki develops metamaterial with high index of refraction
Korean research team was able to theoretically prove that a metamaterial with high index of refraction does exist and produced it experimentally.
Professor Min Beom Ki, Dr. Choi Moo Han, and Doctorate candidate Lee Seung Hoon was joined by Dr. Kang Kwang Yong’s team from ETRI, KAIST’s Professor Less Yong Hee’s team, and Seoul National University’s Professor Park Nam Kyu’s team. The research was funded by the Basic Research Support Program initiated by the Ministry of Education, Science, and Technology and Korea Research Federation.
The result of the research was published in ‘Nature’ magazine and is one of the few researches carried out by teams composed entirely of Koreans.
Metamaterials are materials that have physical properties beyond those materials’ properties that are found in nature. It is formed not with atoms, but with synthetic atoms which have smaller structures than wavelengths.
The optical and electromagnetic waves’ properties of metamaterials can be altered significantly which has caught the attention of scientists worldwide.
Professor Min Beom Ki’s team independently designed and created a dielectric metamaterial with high polarization and low diamagnetism with an index of refraction of 38.6, highest synthesized index value.
It is expected that the result of the experiment will help develop high resolution imaging system and ultra small, hyper sensitive optical devices.
2011.02.23 View 17341
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Interdisciplinary Research on World Environmental Problems with Humanities
KAIST’s Professor Michael Pak (department of Humanities and Social Sciences) has published a paper in ‘Environmental Science and Technology, ES&T’ and was made Lead Feature.
His was the only paper published with a humanities background and his topic of discussion was ‘Environmentalism Then and Now: From Fears to Opportunities, 1970-2010’ in which he discussed the history of pro-environment activities, the patterns it showed, and its outlook.
Professor Park noted that the problems and concerns over the environment is not a recent phenomenon. It took over 50 years for the environmental problems to resurface after being the ‘hot issue’ of the time during the industrial revolution in the 19th century.
Professor Park deduced that there is a clear historical pattern.
Professor Park insisted that the two areas of Environmental Research ‘Global Warming’ and ‘Change in Weather’. Especially because these two areas are rife with uncertainty as it is, and making policies based on inaccurate information is taking a gamble.
Professor Park majored in history in UC Berkeley, received his masters’ and doctorate at Harvard University and was the professor at Massachusetts College of Art and Design before coming to KAIST at 2008.
2011.02.23 View 11567
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Waking Up Is Hard to Do: Scientists have discovered a new mechanism in the core gears of the circadian clock.
The US News & World Report released an article (Feb. 18, 2011) on KAIST’s research collaboration with Northwestern University in the US to identify a gene that regulates the rhythm of a fruit fly’s circadian clock, which may be applied to explain human’s sleep-wake cycle. The research result was published February 17 in the journal Nature.
For the link of the US News & World Report article, please go to the following link:
http://www.usnews.com/science/articles/2011/02/18/waking-up-is-hard-to-do_print.html
2011.02.21 View 10485
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Success in differentiating Functional Vascular Progenitor Cells (VPC)
KAIST’s Professor Han Yong Man successfully differentiated vascular progenitor cells from human embryonic stem cells and reversed differentiated stem cells.
The research went beyond the current method of synthesis of embryonic body or mice cell ball culture and used the careful alteration of signal transmission system of the human embryonic stem cells to differentiate the formation of vascular progenitor cells.
The team controlled the MEK/ERK and BMP signal transmission system that serves an important role in the self replication of human embryonic stem cells and successfully differentiated 20% of the cells experimented on to vascular progenitor cells.
The vascular progenitor cells produced with such a method successfully differentiated into cells forming the endodermis of the blood vessel, vascular smooth muscle cells and hematopoietic cells in an environment outside of the human body and also successfully differentiated into blood vessels in nude mice.
In addition, the vascular progenitor cell derived from human embryonic cells successfully formed blood vessels or secreted vascular growth factors and increased the blood flow and the necrosis of blood vessels when injected into an animal with limb ischemic illness.
The research was funded by the Ministry of Education, Science and Technology, 21st Century Frontier Research and Development Institution’s Cell Application Research Department and Professor Ko Kyu Young (KAIST), Professor Choi Chul Hee (KAIST), Professor Jeong Hyung Min (Cha Medical School) and Doctor Jo Lee Sook (Researcher in Korea Bio Engineering Institute) participated in it.
The results of the research was published as the cover paper of the September edition of “Blood (IF:10.55)”, the American Blood Journal and has been patented domestically and has finished registration of foreign PCT.
The results of the experiment opened the possibility of providing a patient specific cure using stem cells in the field of blood vessel illness.
2011.01.18 View 14190 -
Explanation for the polymerized nucleic acid enzyme's abnormal activation found
KAIST’s Professor Park Hyun Kyu of the Department of Bio Chemical Engineering revealed on the 23rd of December 2010 that his team had successfully developed the technology that uses the metal ions to control the abnormal activation of nucleic acids’ enzymes and using this, created a logic gate, which is a core technology in the field of future bio electrons.
The polymerized nucleic acid enzyme works to increase the synthesis of DNA and kicks into action only when the target DNA and primers form complimentary pairs (A and T, C and G).
Professor Park broke the common conception and found that it is possible for none complimentary pairs like T-T and C-C to initiate the activation of the enzyme and thus increase the nucleic acid production, given that there are certain metal ions present.
What Professor Park realized is that the enzymes mistake the uncomplimentary T-T and C-C pairs (with stabilized structures due to the bonding with mercury and silver ions) as being complimentary base pairs. Professor Park described this phenomenon as the “illusionary polymerase activity.”
The research team developed a logic gate based on the “illusionary polymerase activity’ phenomenon.” The logic gate paves the way to the development of future bio electron needed for bio computers and high performance memories.
Professor Park commented, “The research is an advancement of the previous research carried on about metal ions and nucleic acid synthesis. Our research is the first attempt at merging the concepts of the two previously separately carried out researches and can be adapted for testing presence of metal ions and development of a new single nucleotide polymorphic gene analysis technology.”
Professor Park added that, “Our research is a great stride in the field of nano scale electron element research as the results made possible the formation of accurate logic gates through relatively cost efficient and simple system designs.”
On a side note, the research was funded by Korea Research Foundation (Chairman: Park Chan Mo) and was selected as the cover paper for the December issue of ‘Angewandte Chemie International Edition’.
2011.01.18 View 11454 -
Rise of the mimic-bots that act like we do: Human-machine teamwork.
An online magazine, Technology Marketing Corporation, based in the UK published an article, dated January 8, 2011, on a robot research project led by Professor Jong-Hwan Kim from the Electrical Engineering Department. The article follows below:
Technology Marketing Corporation
[January 08, 2011]
Rise of the mimic-bots that act like we do Human-machine teamwork
(New Scientist Via Acquire Media NewsEdge) Rise of the mimic-bots that act like we doA robot inspired by human mirror neurons can interpret human gestures to learn how it should actNow follow meA robot inspired by human mirror neurons can interpret human gestures to learn how it should actA HUMAN and a robot face each other across the room. The human picks up a ball, tosses it towards the robot, and then pushes a toy car in the same direction.
Confused by two objects coming towards it at the same time, the robot flashes a question mark on a screen. Without speaking, the human makes a throwing gesture. The robot turns its attention to the ball and decides to throw it back.
In this case the robot"s actions were represented by software commands, but it will be only a small step to adapt the system to enable a real robot to infer a human"s wishes from their gestures.
Developed by Ji-Hyeong Han and Jong-Hwan Kim at the Korea Advanced Institute of Science and Technology (KAIST) in Daejeon, the system is designed to respond to the actions of the person confronting it in the same way that our own brains do. The human brain contains specialised cells, called mirror neurons, that appear to fire in the same way when we watch an action being performed by others as they do when we perform the action ourselves. It is thought that this helps us to recognise or predict their intentions.
To perform the same feat, the robot observes what the person is doing, breaks the action down into a simple verbal description, and stores it in its memory. It compares the action it observes with a database of its own actions, and generates a simulation based on the closest match.
The robot also builds up a set of intentions or goals associated with an action. For example, a throwing gesture indicates that the human wants the robot to throw something back. The robot then connects the action "throw" with the object "ball" and adds this to its store of knowledge.
When the memory bank contains two possible intentions that fit the available information, the robot considers them both and determines which results in the most positive feedback from the human?- a smile or a nod, for example. If the robot is confused by conflicting information, it can request another gesture from the human. It also remembers details of each interaction, allowing it to respond more quickly when it finds itself in a situation it has encountered before.
The system should allow robots to interact more effectively with humans, using the same visual cues we use. "Of course, robots can recognise human intentions by understanding speech, but humans would have to make constant, explicit commands to the robot," says Han. "That would be pretty uncomfortable."Socially intelligent robots that can communicate with us through gesture and expression will need to develop a mental model of the person they are dealing with in order to understand their needs, says Chris Melhuish, director of the Bristol Robotics Laboratory in the UK. Using mirror neurons and humans" unique mimicking ability as an inspiration for building such robots could be quite interesting, he says.
Han now plans to test the system on a robot equipped with visual and other sensors to detect people"s gestures. He presented his work at the Robio conference in Tianjin, China, in December. nAs the population of many countries ages, elderly people may share more of their workload with robotic helpers or colleagues. In an effort to make such interactions as easy as possible, Chris Melhuish and colleagues at the Bristol Robotics Laboratory in the UK are leading a Europe-wide collaboration called Cooperative Human Robotic Interaction Systems that is equipping robots with software that recognises an object they are picking up before they hand it to a person. They also have eye-tracking technology that they use to monitor what humans are paying attention to. The goal is to develop robots that can learn to safely perform shared tasks with people, such as stirring a cake mixture as a human adds milk.
(c) 2011 Reed Business Information - UK. All Rights Reserved.
2011.01.10 View 10713
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KAIST developed a plastic film board less sensitive to heat.
The research result was made the cover of magazine, Advanced Materials and is accredited to paving the way to commercialize flexible display screens and solar power cells.
Transparent plastic and glass cloths, which have a limited thermal expansion needed for the production of flexible display screens and solar power cells, were developed by Korean researchers.
The research, led by KAIST’s Professor Byoung-Soo Bae, was funded by the Engineering Research Center under the initiative of the Ministry of Education, Science and Technology and the National Research Foundation. The research result was printed as the cover paper of ‘Advanced Materials’ which is the leading magazine in the field of materials science.
Professor Bae’s team developed a hybrid material with the same properties as fiber glass. With the material, they created a transparent, plastic film sheet resistant to heat. Transparent plastic film sheets were used by researchers all over the world to develop devices such as flexible displays or solar power cells that can be fit into various living spaces. However, plastic films are heat sensitive and tend to expand as temperature increases, thereby making it difficult to produce displays or solar power cells.
The new transparent, plastic film screen shows that heat expansion index (13ppm/oC) similar to that of glass fiber (9ppm/oC) due to the presence of glass fibers; its heat resistance allows to be used for displays and solar power cells over 250oC.
Professor Bae’s team succeeded in producing a flexible thin plastic film available for use in LCD or AMOLED screens and thin solar power cells.
Professor Bae commented, “Not only the newly developed plastic film has superior qualities, compared to the old models, but also it is cheap to produce, potentially bringing forward the day when flexible displays and solar panels become commonplace. With the cooperation of various industries, research institutes and universities, we will strive to improve the existing design and develop it further.”
2011.01.05 View 14677 -
The KAIST & GIT team developed a power generation technology using bendable thin film nano-materials.
Figure description: Flexible thin film nanomaterials produce electricity.
Can a heart implanted micro robot operate permanently?
Can cell phones and tiny robots implanted in the heart operate permanently without having their batteries charged?
It might sound like science fiction, but these things seem to be possible in the near future. The team of Prof. Keon Jae Lee (KAIST, Dept. of Materials Science and Engineering) and Prof. Zhong Lin Wang (Georgia Institute of Technology, Dept. of Materials Science and Engineering) has developed new forms of highly efficient, flexible nanogenerator technology using the freely bendable piezoelectric ceramic thin film nano-materials that can convert tiny movements of the human body (such as heart beats and blood flow) into electrical energy.
The piezoelectric effect refers to voltage generation when pressure or bending strength is applied to piezoelectric materials. The ceramics, containing a perovskite structure, have a high piezoelectric efficiency. Until now, it has been very difficult to use these ceramic materials to fabricate flexible electronic systems due to their brittle property.
The research team, however, has succeeded in developing a bio-eco-friendly ceramic thin film nanogenerator that is freely bendable without breakdown.
Nanogenerator technology, a power generating system without wires or batteries, combines nanotechnology with piezoelectrics that can be used not only in personal mobile electronics but also in bio-implantable sensors or as an energy source for micro robots. Energy sources in nature (wind, vibration, and sound) and biomechanical forces produced by the human body (heart beats, blood flow, and muscle contraction/relaxation) can infinitely produce nonpolluting energy. (Nanogenerator produces electricity by external forces: http://www.youtube.com/watch?v=tvj0SsBqpBw)
Prof. Keon Jae Lee (KAIST) was involved in the first co-invention of “High Performance Flexible Single Crystal Electronics” during his PhD course at the University of Illinois at Urbana-Champaign. This nanogenerator technology, based on the previous invention, utilized the similar protocol of transferring ceramic thin film nano-materials on flexible substrates and produced voltage generation between electrodes.
Prof. Zhong Lin Wang (Georgia Tech, inventor of the nanogenerator) said, “This technology can be used to turn on an LED by slightly modifying circuits and operate touchable flexible displays. In addition, thin film nano-materials (‘barium titanate’) of this research have the property of both high efficiency and lead-free bio compatibility, which can be used in future medical applications.” This result is published in November online issue of ‘Nano Letters’ ACS journal.
<Video>
Youtube link: http://www.youtube.com/watch?v=tvj0SsBqpBw
Thin Film Nanogenerator produces electricity by external forces.
2010.11.23 View 15439 -
KAIST Student Earns Five Hundred Million Won on Virtual Thumb Idea.
Hwang Sung Jae, a PhD candidate at the Graduate School of Cultural Technology, developed a Virtual Thumb technology that allows multi-touch functions with one hand. Hwang got his idea from limitations of current mobile phones, including the covering of the screen by the use of fingers and the fact that multi-touch functions are hard to perform with one hand holding the mobile phone.
With this technology, one finger gives the same effect of using both fingers to perform a function. Using the Virtual Thumb that appears on a point corresponding to the point of physical touch, movements corresponding to actual touch movements are mimed to allow zooming in/out and various rotation angle based functions.
In addition, in situations where object rotation is unnecessary, many functions are subjectively matched using the change in rotational angle. It allows for various commands are simultaneously executed without activating a separate commanding menu. In the case of the zoom in command at a corner region, the corner can be zoomed in without moving the object to the center of the screen.
The Virtual Thumb technology can be applied as a middleware on touch-based apparatus including TV remote controls, eBook, mobile phones, tablet PCs, navigation systems and educational apparatus.
“I am honored that a small idea that developed during research can be developed into an actual commercialized technology,” said Hwang. “I will become a researcher who will add to the academic and industrial fields through creative research in the future.”
2010.11.05 View 9519 -
Minister of Higher Education of Saudi Arabia Visited KAIST to Sign Agreement on Joint Research Projects
Khaled bin Mohammad Al-Anqari, the Minister of Higher Education of Saudi Arabia, visited KAIST on October 26th to conclude a joint agreement with KAIST.
The group of Saudi Arabian visitors included Abdullah bin Abdularhman Al-Othman, President of the King Saud University, Osama bin Sadiq Tayeb, President of King Abdulaziz University, and Khalid bin Salih Al-Sultan, President of the best Saudi Arabian technological university, King Fahad University of Petroleum and Minerals.
Through research agreement between KAIST and the King Saud University and King Fahad University of Petroleum and Minerals, joint research projects, mutual visitations of research professors, interchange of academic programs, joint seminars and scientific societies will be held to promote the lively interchange between higher education institutions of Korea and Saudi Arabia.
In particular, King Saud University and KAIST has signed an agreement on joint research projects in the fields of “Solar-Ocean Thermal Exchange Desalination,” “Develop New Energy Management Service for Residential and Commercial Customers Using Smart Metering and Sensor Network Information” and “Superior Production of Lactic Acid from Saudi Dates Using Bioprocess Technology.”
The projects will be funded by the Saudi Arabian government, and their scope will be determined in the future
“Compared to the robust industrial economic interactions between the Middle East and Korea, the interchange of the two countries’ higher education institutions has been poor,” said Jong Hyun Kim, Visiting Professor of Nuclear & Quantum Engineering Department of KAIST who will be conducting one of the joint programs with the Electrical Engineering Department of the King Saud University. “Like this joint research, I hope KAIST will, in many different ways, lead the way in cooperating and interacting with higher education institutions of the Middle EAST.”
Al-Anquari, Minister of Higher Education of Saudi Arabia, who showed great interest in KAIST’s innovative research and high technology development, expressed his will to put more effort into extending the interchange between universities of Saudi Arabia and of Korea, including KAIST.
2010.11.03 View 15781 -
2010 International Presidential Forum was held successfully.
On October 11th, the 2010 International Presidential Forum on “The Role of the Research University in an S&T Dominated Era: Expectation & Delivery” was held successfully at the Westin Chosun Hotel in Seoul. The third International Presidential Forum to be held, participants of the 2010 Presidential Forum engaged in an in-depth discussion about the direction that research universities should take in the 21st Century.
On its opening, President Nam Pyo Suh delivered a congratulatory message saying, “This forum is a meaningful gathering where research universities will suggest role models and find ways research universities can contribute to the progress of mankind in this century.”
Following, Lee Ki Jun, CEO of the Korean Federation of Science and Technology Societies said, “The common goal of the world’s research universities is to solve the problems mankind is facing together. I believe that the discussion we will hold today at the forum will point to the future direction of research universities.”
“To produce next generation engineers meeting global standards, exchange and dual degree programs between universities must be strengthened,” said Lars Pallesen, President of the Technical University of Denmark. “Research universities must support the exchange between students beyond cultural and national borders to adapt to the global market.”
Ichiro Okura, Vice President of Tokyo Institute of Technology, presented on the “Asian Science and Technology Pioneering Institutes of Research and Education, ASPIRE.” ASPIRE is a community created by the coalition between science and technology universities in the Far East. Its purpose is to contribute to sustainable global growth by educating high-quality human resources and lead Asia’s technology innovation based on science and technology development.
“For research universities to solve today’s global issues, universities must create new ideas by performing fundamental studies and developing innovative technology. The financial resources of universities must be focused with choices based on results,” remarked President Suh.
Zaini Ujang, Vice-President of the Universiti Teknologi Malaysia stated that “the Malaysian government is planning on converting from a ‘labor-intensive economy’ to an ‘innovative leading economy’ with the goal of joining the advanced countries by 2020. In today’s science and technology era where innovative technology is necessary, research universities have an important role of developing the knowledge environmental system to lead the world economy.” Vice-President Ujang then explained what strategies Malaysian research universities devised in the innovative leading economy era to create research universities that bring creativity and innovation.
Tod A. Laursen, President of KUSTAR, said that “KUSTAR has a leading role in bringing science and technology and manpower necessary in converting the oil-centered economy of UAE to a knowledge-based economy. KUSTAR will continuously strengthen international cooperation to become not only the best engineering university in the Arab region but in the world.”
At this year’s forum, thirty international presidents and vice presidents from 24 universities in 15 countries including Georgia Tech, Technical University of Denmark, Technion-Israel Institute of Technology, University of Queensland, Tokyo University, Nanyang Technological University, University Teknologi Malaysia and Hong Kong Institute of Science and Technology along with forty national figures such as the presidents of Hanyang University and Handong Global University, governmental bureaucrats and representatives from national business and institutions participated.
2010.10.20 View 16514