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Five Projects Ranked in the Top 100 for National R&D Excellence
Five KAIST research projects were selected as the 2021 Top 100 for National R&D Excellence by the Ministry of Science and ICT and the Korea Institute of Science & Technology Evaluation and Planning.
The five projects are:-The development of E. coli that proliferates with only formic acid and carbon dioxide by Distinguished Professor Sang Yup Lee from the Department of Chemical and Biomolecular Engineering
-An original reverse aging technology that restores an old human skin cell into a younger one by Professor Kwang-Hyun Cho from the Department of Bio and Brain Engineering-The development of next-generation high-efficiency perovskite-silicon tandem solar cells by Professor Byungha Shin from the Department of Materials Science and Engineering-Research on the effects of ultrafine dust in the atmosphere has on energy consumption by Professor Jiyong Eom from the School of Business and Technology Management-Research on a molecular trigger that controls the phase transformation of bio materials by Professor Myungchul Kim from the Department of Bio and Brain Engineering
Started in 2006, an Evaluation Committee composed of experts in industries, universities, and research institutes has made the preliminary selections of the most outstanding research projects based on their significance as a scientific and technological development and their socioeconomic effects. The finalists went through an open public evaluation. The final 100 studies are from six fields: 18 from mechanics & materials, 26 from biology & marine sciences, 19 from ICT & electronics, 10 from interdisciplinary research, and nine from natural science and infrastructure.
The selected 100 studies will receive a certificate and an award plaque from the minister of MSIT as well as additional points for business and institutional evaluations according to appropriate regulations, and the selected researchers will be strongly recommended as candidates for national meritorious awards.
In particular, to help the 100 selected research projects become more accessible for the general public, their main contents will be provided in a free e-book ‘The Top 100 for National R&D Excellence of 2021’ that will be available from online booksellers.
2022.02.17 View 8275 -
Thermal Superconductor Lab Becomes the 7th Cross-Generation Collaborative Lab
The Thermal Superconductor Lab led by Senior Professor Sung Jin Kim from the Department of Mechanical Engineering will team up with Junior Professor Youngsuk Nam to develop next-generation superconductors. The two professor team was selected as the 7th Cross-Generation Collaborative Lab last week and will sustain the academic legacy of Professor Kim’s three decades of research on superconductors. The team will continue to develop thin, next-generation superconductors that carry super thermal conductivity using phase transition control technology and thin film packaging.
Thin-filmed, next-generation superconductors can be used in various high-temperature flexible electronic devices. The superconductors built inside of the semiconductor device packages will also be used for managing the low-powered but high-performance temperatures of semiconductor and electronic equipment.
Professor Kim said, “I am very pleased that my research, know-how, and knowledge from over 30 years of work will continue through the Cross-Generation Collaborative Lab system with Professor Nam. We will spare no effort to advance superconductor technology and play a part in KAIST leading global technology fields.” Junior Professor Nam also stressed that the team is excited to continue its research on crucial technology for managing the temperatures of semiconductors and other electronic equipment.
KAIST started this innovative research system in 2018, and in 2021 it established the steering committee to select new labs based on: originality, differentiation, and excellence; academic, social, economic impact; the urgency of cross-generation research; the senior professor’s academic excellence and international reputation; and the senior professor’s research vision. Selected labs receive 500 million KRW in research funding over five years.
2022.01.27 View 4674 -
Perigee-KAIST Rocket Research Center Launches Scientific Rocket
Undergraduate startup Perigree Aerospace develops suborbital rocket called Blue Whale 0.1
On December 29, Perigee Aerospace, an undergraduate startup, launched a test rocket with a length of 3.2 m, a diameter of 19 cm, and a weight of 51 kg, using ethanol and liquid oxygen as fuel. The launch took place off Jeju Island. It was aimed at building experience and checking the combustion of a liquid propulsion engine and the performance of pre-set flight and trajectory, communication, and navigation devices. It was also one of the projects marking the 50th anniversary of KAIST in 2021.
However, after flying for several seconds, the rocket lost its track due to a gust of wind that activated the rocket’s automatic flight suspension system. "At the moment the rocket took off, there was a much stronger gust than expected," Dong-Yoon Shin, CEO of Perigee said. "The wind sent it flying off course and the automatic flight suspension system stopped its engine." However, Shin was not disappointed, saying the launch, which was conducted in collaboration with Perigee-KAIST Rocket Research Center provided a good experience.
"Some people say that Blue Whale 0.1 is like a toy because of its small size. Of course, it's much smaller than the rockets I’ve dreamed of, but like other rockets, it has all the technology needed for launch," said Shin, who established his company in 2018 as a KAIST aerospace engineering student to develop small liquid-propellant orbital rockets. Perigee Aerospace aims to develop the world’s lightest launch vehicle using high-powered engines, with a goal of leading the global market for small launch vehicles in the new space generation.
Perigee-KAIST Rocket Research Center was founded in 2019 for the research and development of rocket propellants and has been testing the combustion of rocket engines of various sizes in their liquid propellant rocket combustion lab located on the KAIST Munji Campus.
The research center initiated the 50th anniversary rocket launch project in late April of last year, finished the examination of their preliminary design in late May, and secured a tentative launching site through the KAIST-Jejudo agreement in early July.
The ethanol engine combustion was tested in late July, and an examination meeting regarding the detailed design that took place in late August was followed by two months of static firing tests of the assembled rocket in October and November.
This was a very meaningful trial in which a domestic private enterprise founded by a college student collaborated with a university to successfully develop and launch a technically challenging liquid propellant rocket.
Shin's near-term goal is to launch a two-stage orbital rocket that uses liquid methane as fuel and weighs 1.8 tons. To secure competitiveness in the small projectile market, KAIST and Perigee Aerospace have set up a joint research center to test various rocket engine sizes and develop the world's lightest projectile using a high-performance engine.
Professor Jae-Hung Han, head of the Department of Aerospace Engineering, said, “The scientific rocket system secured through the launch of the celebratory rocket will be utilized for design and system-oriented education, and for carrying out various scientific missions.” He added, “It is very rare both domestically and globally that a scientific rocket designed by the initiatives of a department should be incorporated as part of a regular aerospace system design curriculum. This will be an exemplary case we can boast about to the rest of the world.”
Perigee Aerospace will improve the technology they have developed through the course of this project to develop subminiature vehicles they may use to launch small satellites into the low Earth orbit.
Shin said, “I am happy just with the fact that we have participated in a rocket project to celebrate the 50th anniversary of KAIST, and I would like to thank the engineers at my company and members of the KAIST Department of Aerospace Engineering.” He added, “I’m looking forward to the day that we develop a space launch vehicle that can deliver satellites even higher.”
2022.01.14 View 6681 -
KAIST ISPI Releases Report on the Global AI Innovation Landscape
Providing key insights for building a successful AI ecosystem
The KAIST Innovation Strategy and Policy Institute (ISPI) has launched a report on the global innovation landscape of artificial intelligence in collaboration with Clarivate Plc. The report shows that AI has become a key technology and that cross-industry learning is an important AI innovation. It also stresses that the quality of innovation, not volume, is a critical success factor in technological competitiveness.
Key findings of the report include:
• Neural networks and machine learning have been unrivaled in terms of scale and growth (more than 46%), and most other AI technologies show a growth rate of more than 20%.
• Although Mainland China has shown the highest growth rate in terms of AI inventions, the influence of Chinese AI is relatively low. In contrast, the United States holds a leading position in AI-related inventions in terms of both quantity and influence.
• The U.S. and Canada have built an industry-oriented AI technology development ecosystem through organic cooperation with both academia and the Government. Mainland China and South Korea, by contrast, have a government-driven AI technology development ecosystem with relatively low qualitative outputs from the sector.
• The U.S., the U.K., and Canada have a relatively high proportion of inventions in robotics and autonomous control, whereas in Mainland China and South Korea, machine learning and neural networks are making progress. Each country/region produces high-quality inventions in their predominant AI fields, while the U.S. has produced high-impact inventions in almost all AI fields.
“The driving forces in building a sustainable AI innovation ecosystem are important national strategies. A country’s future AI capabilities will be determined by how quickly and robustly it develops its own AI ecosystem and how well it transforms the existing industry with AI technologies. Countries that build a successful AI ecosystem have the potential to accelerate growth while absorbing the AI capabilities of other countries. AI talents are already moving to countries with excellent AI ecosystems,” said Director of the ISPI Wonjoon Kim.
“AI, together with other high-tech IT technologies including big data and the Internet of Things are accelerating the digital transformation by leading an intelligent hyper-connected society and enabling the convergence of technology and business. With the rapid growth of AI innovation, AI applications are also expanding in various ways across industries and in our lives,” added Justin Kim, Special Advisor at the ISPI and a co-author of the report.
2021.12.21 View 6166 -
Team KAIST to Race at CES 2022 Autonomous Challenge
Five top university autonomous racing teams will compete in a head-to-head passing competition in Las Vegas
A self-driving racing team from the KAIST Unmanned System Research Group (USRG) advised by Professor Hyunchul Shim will compete at the Autonomous Challenge at the Consumer Electronic Show (CES) on January 7, 2022. The head-to-head, high speed autonomous racecar passing competition at the Las Vegas Motor Speedway will feature the finalists and semifinalists from the Indy Autonomous Challenge in October of this year. Team KAIST qualified as a semifinalist at the Indy Autonomous Challenge and will join four other university teams including the winner of the competition, Technische Universität München.
Team KAIST’s AV-21 vehicle is capable of driving on its own at more than 200km/h will be expected to show a speed of more than 300 km/h at the race.The participating teams are:1. KAIST2. EuroRacing : University of Modena and Reggio Emilia (Italy), University of Pisa (Italy), ETH Zürich (Switzerland), Polish Academy of Sciences (Poland) 3. MIT-PITT-RW, Massachusetts Institute of Technology, University of Pittsburgh, Rochester Institute of Technology, University of Waterloo (Canada)4.PoliMOVE – Politecnico di Milano (Italy), University of Alabama 5.TUM Autonomous Motorsport – Technische Universität München (Germany)
Professor Shim’s team is dedicated to the development and validation of cutting edge technologies for highly autonomous vehicles. In recognition of his pioneering research in unmanned system technologies, Professor Shim was honored with the Grand Prize of the Minister of Science and ICT on December 9.
“We began autonomous vehicle research in 2009 when we signed up for Hyundai Motor Company’s Autonomous Driving Challenge. For this, we developed a complete set of in-house technologies such as low-level vehicle control, perception, localization, and decision making.” In 2019, the team came in third place in the Challenge and they finally won this year.
For years, his team has participated in many unmanned systems challenges at home and abroad, gaining recognition around the world. The team won the inaugural 2016 IROS autonomous drone racing and placed second in the 2018 IROS Autonomous Drone Racing Competition. They also competed in 2017 MBZIRC, ranking fourth in Missions 2 and 3, and fifth in the Grand Challenge.
Most recently, the team won the first round of Lockheed Martin’s Alpha Pilot AI Drone Innovation Challenge. The team is now participating in the DARPA Subterranean Challenge as a member of Team CoSTAR with NASA JPL, MIT, and Caltech.
“We have accumulated plenty of first-hand experience developing autonomous vehicles with the support of domestic companies such as Hyundai Motor Company, Samsung, LG, and NAVER. In 2017, the autonomous vehicle platform “EureCar” that we developed in-house was authorized by the Korean government to lawfully conduct autonomous driving experiment on public roads,” said Professor Shim.
The team has developed various key technologies and algorithms related to unmanned systems that can be categorized into three major components: perception, planning, and control. Considering the characteristics of the algorithms that make up each module, their technology operates using a distributed computing system.
Since 2015, the team has been actively using deep learning algorithms in the form of perception subsystems. Contextual information extracted from multi-modal sensory data gathered via cameras, lidar, radar, GPS, IMU, etc. is forwarded to the planning subsystem. The planning module is responsible for the decision making and planning required for autonomous driving such as lane change determination and trajectory planning, emergency stops, and velocity command generation. The results from the planner are fed into the controller to follow the planned high-level command. The team has also developed and verified the possibility of an end-to-end deep learning based autonomous driving approach that replaces a complex system with one single AI network.
2021.12.17 View 8429 -
A Genetic Change for Achieving a Long and Healthy Life
Researchers identified a single amino acid change in the tumor suppressor protein in PTEN that extends healthy periods while maintaining longevity
Living a long, healthy life is everyone’s wish, but it is not an easy one to achieve. Many aging studies are developing strategies to increase health spans, the period of life spent with good health, without chronic diseases and disabilities. Researchers at KAIST presented new insights for improving the health span by just regulating the activity of a protein.
A research group under Professor Seung-Jae V. Lee from the Department of Biological Sciences identified a single amino acid change in the tumor suppressor protein phosphatase and tensin homolog (PTEN) that dramatically extends healthy periods while maintaining longevity. This study highlights the importance of the well-conserved tumor suppressor protein PTEN in health span regulation, which can be targeted to develop therapies for promoting healthy longevity in humans. The research was published in Nature Communications on September 24, 2021.
Insulin and insulin-like growth factor-1 (IGF-1) signaling (IIS) is one of the evolutionarily conserved aging-modulatory pathways present in life forms ranging from tiny roundworms to humans. The proper reduction of IIS leads to longevity in animals but often causes defects in multiple health parameters including impaired motility, reproduction, and growth.
The research team found that a specific amino acid change in the PTEN protein improves health status while retaining the longevity conferred by reduced IIS. They used the roundworm C. elegans, an excellent model animal that has been widely used for aging research, mainly because of its very short normal lifespan of about two to three weeks. The PTEN protein is a phosphatase that removes phosphate from lipids as well as proteins. Interestingly, the newly identified amino acid change delicately recalibrated the IIS by partially maintaining protein phosphatase activity while reducing lipid phosphatase activity.
As a result, the amino acid change in the PTEN protein maintained the activity of the longevity-promoting transcription factor Forkhead Box O (FOXO) protein while restricting the detrimental upregulation of another transcription factor, NRF2, leading to long and healthy life in animals with reduced IIS.
Professor Lee said, “Our study raises the exciting possibility of simultaneously promoting longevity and health in humans by slightly tweaking the activity of one protein, PTEN.”
This work was supported by the MInistry of Science and ICT through the National Research Foundation of Korea.
-Publication:Hae-Eun H. Park, Wooseon Hwang, Seokjin Ham, Eunah Kim, Ozlem Altintas, Sangsoon Park, Heehwa G. Son, Yujin Lee, Dongyeop Lee, Won Do Heo, and Seung-Jae V. Lee. 2021. “A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling,” Nature Communications, 12(1), 5631. (https://doi.org/10.1038/s41467-021-25920-w)
-ProfileProfessor Seung-Jae V. LeeMolecular Genetics of Aging LaboratoryDepartment of Biological Sciences KAIST
2021.11.19 View 6933 -
Seegene Opens Covid-19 Testing Mobile Station on Campus
Seegene donates testing reagents for 40,000 people with results available in three hours
Seegene, a molecular diagnostic testing company, donated enough testing reagents for 40,000 COVID-19 tests for the KAIST community and set up a mobile testing station run by the Seegene Medical Foundation on October 28.
The entire COVID-19 diagnosis process, including specimen collection, PCR testing, and results analysis, can be conducted at the mobile testing unit developed by Seegene. The on-site testing station will help the campus get ready to return to normal, especially as the government is transitioning toward its ‘living with Covid-19’ policy, which eases a range of social distancing restrictions. Any KAIST community member can get a Covid-19 test on campus and receive the results within three hours. The station can conduct up to 7,500 tests per day.
This is an extension of the agreement between KAIST and Seegene made in July for research collaboration. The two institutions will work together on various research projects including ultrafast PCR testing, sample collection, and cloud-based data transmission and analysis.
Prior to this donation, according to an administrative order from Daejeon City, KAIST opened a temporary COVID-19 testing center in collaboration with Seegene and conducted COVID-19 tests at the KAIST Clinic over four days starting from September 28. All students living on campus were tested, and all 2,775 tested negative.
Seegene CEO Jong-Yoon Chun said, "KAIST and Seegene signed an agreement for collaborative research on molecular diagnosis in July prior to this donation, and we are happy to maintain a connection with KAIST.” He added, “We hope that this donation will help students return to their ordinary university lives.”
Vice President for Planning and Budget Bowon Kim said, "As KAIST is currently planning to conduct offline lectures in preparation for ‘living with COVID-19’, Seegene’s donation will be particularly helpful.” He added, “The two institutions will continue to cooperate, leading to not only the short-term stabilization of the campus, but also collaborative research for the vitalization of molecular diagnosis technology and the bio industry.”
2021.11.03 View 4814 -
Hubo Professor Jun-Ho Oh Donates Startup Shares Worth 5 Billion KRW
Rainbow Robotics stock used to endow the development fund
Emeritus Professor Jun-Ho Oh, who developed the 2015 DARPA Challenge winning humanoid robot DRC-Hubo, donated 5 billion KRW on October 25 during a ceremony held at the KAIST campus in Daejeon.
Professor Oh donated his 20% share (400 shares) of his startup Rainbow Robotics, which was established in 2011. Rainbow Robotics was listed on the KOSDAQ this February. The 400 shares were converted to 200,000 shares with a value of approximately 5 billion KRW when listed this year.
KAIST sold the stocks and endowed the Jun-Ho Oh Fund, which will be used for the development of the university. He was the 39th faculty member who launched a startup with technology from his lab and became the biggest faculty entrepreneur donor.
“I have received huge support and funding for my research. Fortunately, the research had a good result and led to the startup. Now I am very delighted to pay back the university. I feel that I have played a part in building the school’s startup ecosystem and creating a virtuous circle,” said Professor Oh during the ceremony.
KAIST President Kwang Hyung Lee declared, “Professor Oh has been a very impressive exemplary model for our aspiring faculty and student tech startups. We will spare no effort to support startups at KAIST.”
Professor Oh, who retired from the Department of Mechanical Engineering last year, now serves as the CTO at Rainbow Robotics. The company is developing humanoid bipedal robots and collaborative robots, and advancing robot technology including parts for astronomical observations.
Professor Hae-Won Park and Professor Je Min Hwangbo, who are now responsible for the Hubo Lab, also joined the ceremony along with employees of Rainbow Robotics.
2021.10.26 View 6908 -
Diva Sumi Jo to Join the KAIST Faculty
Visiting Distinguished Professor Jo will enrich KAIST’s scholarship and inspire futuristic art and technology research
Soprano Sumi Jo will join the KAIST faculty from the spring 2022 semester. Named as a visiting distinguished professor in the Graduate School of Culture Technology, she will give special leadership lectures. Her tenure will be through September 2024.
Jo joined the appointment ceremony held online at KAIST on October 14 from Portugal and expressed her high expectations for teaching KAIST students from next year. “I am very grateful for this opportunity to meet students at KAIST, the birthplace of advanced science and technology in Korea,” she said.
KAIST President Kwang Hyung Lee, who has stressed the importance of humanities and the arts in convergence studies of science and technology, lauded her joining the faculty as a big asset who will enrich KAIST’s scholarship. “Soprano Sumi Jo rose to stardom on the global music stage with her unrivaled talent and effort. I truly believe her experience and passion will inspire our students to expand their horizon of thought and knowledge,” said President Lee.
Distinguished Professor Jo will also participate in convergence research at the Graduate School of Culture Technology with KAIST professors and many other experts. The Sumi Jo Performing Arts Research Center at the Graduate School of Culture Technology will conduct research on the converging of imaging and audio processing technologies that will enhance virtual artists’ performances. Distinguished Professor Jo explained, “The world is changing so fast. I look forward to working on culture technology research at KAIST that will raise our life quality.”
Professor Juhan Nam from the Graduate School of Culture Technology said, “We look forward to working closely with her and her team to develop research themes that envision futuristic art combined with technology such as the metaverse and non-fungible tokens (NFTs).
Coloratura soprano Jo was born in Seoul and educated at Seoul National University and the Conservatorio Santa Cecilia in Italy. Among her teachers were Carolo Bergonzi and Giasnnelas Borelli. Following her graduation from the Conservatorio Santa Cecilia in 1985, she swept major international competitions in Seoul and Europe. In 1986, she was unanimously awarded the first prize in the Carlo Alberto Cappelli International Competition in Verona which is open only to the first-prize winners of major competitions.
Since her debut in the role of Gilda in Verdi’s Rigolleto in Italy in 1986, she has performed on the world's biggest stages along with noted maestros such as Herbert von Karajan, Georg Solti, Zubin Mehta, and James Levine. Distinguished Professor Jo, one of the most sought-after sopranos in the world, released more than 40 albums.
2021.10.15 View 4973 -
Genomic Data Reveals New Insights into Human Embryonic Development
KAIST researchers have used whole-genome sequencing to track the development from a single fertilized-egg to a human body
Genomic scientists at KAIST have revealed new insights into the process of human embryonic development using large-scale, whole-genome sequencing of cells and tissues from adult humans. The study, published in Nature on Aug.25, is the first to analyse somatic mutations in normal tissue across multiple organs within and between humans.
An adult human body comprises trillions of cells of more than 200 types. How a human develops from a single fertilized egg to a fully grown adult is a fundamental question in biomedical science. Due to the ethical challenges of performing studies on human embryos, however, the details of this process remain largely unknown.
To overcome these issues, the research team took a different approach. They analysed genetic mutations in cells taken from adult human post-mortem tissue. Specifically, they identified mutations that occur spontaneously in early developmental cell divisions. These mutations, also called genomic scars, act like unique genetic fingerprints that can be used to trace the embryonic development process.
The study, which looked at 334 single-cell colonies and 379 tissue samples from seven recently deceased human body donors, is the largest single-cell, whole-genome analysis carried out to date. The researchers examined the genomic scars of each individual in order to reconstruct their early embryonic cellular dynamics.
The result revealed several key characteristics of the human embryonic development process. Firstly, mutation rates are higher in the first cell division, but then decrease to approximately one mutation per cell during later cell division. Secondly, early cells contributed unequally to the development of the embryo in all informative donors, for example, at the two-cell stage, one of the cells always left more progeny cells than the other. The ratio of this was different from person to person, implying that the process varies between individuals and is not fully deterministic.
The researchers were also able to deduce the timing of when cells begin to differentiate into individual organ-specific cells. They found that within three days of fertilization, embryonic cells began to be distributed asymmetrically into tissues for the left and right sides of the body, followed by differentiation into three germ layers, and then differentiation into specific tissues and organs.
“It is an impressive scientific achievement that, within 20 years of the completion of human genome project, genomic technology has advanced to the extent that we are now able to accurately identify mutations in a single-cell genome,” said Professor Young Seok Ju from the Graduate School of Medical Science and Engineering at KAIST. “This technology will enable us to track human embryogenesis at even higher resolutions in the future.”
The techniques used in this study could be used to improve our understanding of rare diseases caused by abnormalities in embryonic development, and to design new precision diagnostics and treatments for patients.
The research was completed in collaboration with Kyungpook National University Hospital, the Korea Institute of Science and Technology Information, Catholic University of Korea School of Medicine, Genome Insights Inc, and Immune Square Inc. This work was supported by the Suh Kyungbae Foundation, the Ministry of Health and Welfare of Korea, the National Research Foundastion of Korea.
-PublicationSeongyeol Park, Nanda Mali, Ryul Kim et al. ‘Clonal dynamics in early human embryogenesis inferred from somatic mutation’ Nature Online ahead of print, Aug. 25, 2021 (https://doi.org/10.1038/s41586-021-03786-8)
-ProfileProfessor Young Seok JuLab of Cancer Genomics (https://www.julab.kaist.ac.kr/)Graduate School of Medical Science and EngineeringKAIST
2021.08.31 View 7088 -
A Mechanism Underlying Most Common Cause of Epileptic Seizures Revealed
An interdisciplinary study shows that neurons carrying somatic mutations in MTOR can lead to focal epileptogenesis via non-cell-autonomous hyperexcitability of nearby nonmutated neurons
During fetal development, cells should migrate to the outer edge of the brain to form critical connections for information transfer and regulation in the body. When even a few cells fail to move to the correct location, the neurons become disorganized and this results in focal cortical dysplasia. This condition is the most common cause of seizures that cannot be controlled with medication in children and the second most common cause in adults.
Now, an interdisciplinary team studying neurogenetics, neural networks, and neurophysiology at KAIST has revealed how dysfunctions in even a small percentage of cells can cause disorder across the entire brain. They published their results on June 28 in Annals of Neurology.
The work builds on a previous finding, also by a KAIST scientists, who found that focal cortical dysplasia was caused by mutations in the cells involved in mTOR, a pathway that regulates signaling between neurons in the brain.
“Only 1 to 2% of neurons carrying mutations in the mTOR signaling pathway that regulates cell signaling in the brain have been found to include seizures in animal models of focal cortical dysplasia,” said Professor Jong-Woo Sohn from the Department of Biological Sciences. “The main challenge of this study was to explain how nearby non-mutated neurons are hyperexcitable.”
Initially, the researchers hypothesized that the mutated cells affected the number of excitatory and inhibitory synapses in all neurons, mutated or not. These neural gates can trigger or halt activity, respectively, in other neurons. Seizures are a result of extreme activity, called hyperexcitability. If the mutated cells upend the balance and result in more excitatory cells, the researchers thought, it made sense that the cells would be more susceptible to hyperexcitability and, as a result, seizures.
“Contrary to our expectations, the synaptic input balance was not changed in either the mutated or non-mutated neurons,” said Professor Jeong Ho Lee from the Graduate School of Medical Science and Engineering. “We turned our attention to a protein overproduced by mutated neurons.”
The protein is adenosine kinase, which lowers the concentration of adenosine. This naturally occurring compound is an anticonvulsant and works to relax vessels. In mice engineered to have focal cortical dysplasia, the researchers injected adenosine to replace the levels lowered by the protein. It worked and the neurons became less excitable.
“We demonstrated that augmentation of adenosine signaling could attenuate the excitability of non-mutated neurons,” said Professor Se-Bum Paik from the Department of Bio and Brain Engineering.
The effect on the non-mutated neurons was the surprising part, according to Paik. “The seizure-triggering hyperexcitability originated not in the mutation-carrying neurons, but instead in the nearby non-mutated neurons,” he said.
The mutated neurons excreted more adenosine kinase, reducing the adenosine levels in the local environment of all the cells. With less adenosine, the non-mutated neurons became hyperexcitable, leading to seizures.
“While we need further investigate into the relationship between the concentration of adenosine and the increased excitation of nearby neurons, our results support the medical use of drugs to activate adenosine signaling as a possible treatment pathway for focal cortical dysplasia,” Professor Lee said.
The Suh Kyungbae Foundation, the Korea Health Technology Research and Development Project, the Ministry of Health & Welfare, and the National Research Foundation in Korea funded this work.
-Publication:Koh, H.Y., Jang, J., Ju, S.H., Kim, R., Cho, G.-B., Kim, D.S., Sohn, J.-W., Paik, S.-B. and Lee, J.H. (2021), ‘Non–Cell Autonomous Epileptogenesis in Focal Cortical Dysplasia’ Annals of Neurology, 90: 285 299. (https://doi.org/10.1002/ana.26149)
-ProfileProfessor Jeong Ho Lee Translational Neurogenetics Labhttps://tnl.kaist.ac.kr/ Graduate School of Medical Science and Engineering KAIST
Professor Se-Bum Paik Visual System and Neural Network Laboratory http://vs.kaist.ac.kr/ Department of Bio and Brain EngineeringKAIST
Professor Jong-Woo Sohn Laboratory for Neurophysiology, https://sites.google.com/site/sohnlab2014/home Department of Biological SciencesKAIST
Dr. Hyun Yong Koh Translational Neurogenetics LabGraduate School of Medical Science and EngineeringKAIST
Dr. Jaeson Jang Ph.D.Visual System and Neural Network LaboratoryDepartment of Bio and Brain Engineering KAIST
Sang Hyeon Ju M.D.Laboratory for NeurophysiologyDepartment of Biological SciencesKAIST
2021.08.26 View 10374 -
A Study Reveals What Triggers Lung Damage during COVID-19
A longitudinal study of macrophages from SARS-CoV-2 infected lungs offers new insights into dynamic immunological changes
A KAIST immunology research team found that a specific subtype of macrophages that originated from blood monocytes plays a key role in the hyper-inflammatory response in SARS-CoV-2 infected lungs, by performing single-cell RNA sequencing of bronchoalveolar lavage fluid cells. This study provides new insights for understanding dynamic changes in immune responses to COVID-19.
In the early phase of COVID-19, SARS-CoV-2 infected lung tissue and the immediate defense system is activated. This early and fast response is called ‘innate immunity,’ provided by immune cells residing in lungs. Macrophages are major cell types of the innate immune system of the lungs, and newly differentiated macrophages originating from the bloodstream also contribute to early defenses against viruses.
Professor Su-Hyung Park and his collaborators investigated the quantitative and qualitative evaluation of immune responses in the lungs of SARS-CoV-2 infected ferrets. To overcome the limitations of research using patient-originated specimens, the researchers used a ferret infection model to obtain SARS-CoV-2 infected lungs sequentially with a defined time interval.
The researchers analyzed the 10 subtypes of macrophages during the five-day course of SARS-CoV-2 infection, and found that infiltrating macrophages originating from activated monocytes in the blood were key players for viral clearance as well as damaged lung tissue. Moreover, they found that the differentiation process of these inflammatory macrophages resembled the immune responses in the lung tissue of severe COVID-19 patients.
Currently, the research team is conducting a follow-up study to identify the dynamic changes in immune responses during the use of immunosuppressive agents to control hyper-inflammatory response called ‘cytokine storm’ in patients with COVID-19.
Dr. Jeong Seok Lee, the chief medical officer at Genome Insight Inc., explained, “Our analysis will enhance the understanding of the early features of COVID-19 immunity and provide a scientific background for the more precise use of immunosuppressive agents targeting specific macrophage subtypes.”
“This study is the first longitudinal study using sequentially obtained immune cells originating from SARS-CoV-2 infected lungs. The research describes the innate immune response to COVID-19 using single cell transcriptome data and enhances our understanding of the two phases of inflammatory responses,” Professor Park said.
This work was supported by the Ministry of Health and Welfare and KAIST, and was published in Nature Communications on July 28.
-PublicationSu-Hyung Park, Jeong Seok Lee, Su-Hyung Park et al. “Single-cell transcriptome of bronchoalverolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets” Nature Communications (https://doi.org/10.1038/s41467-021-24807-0)
-ProfileProfessor Su-Hyung ParkLaboratory of Translational Immunology and Vaccinologyhttps://ltiv.kaist.ac.kr/
Graduate School of Medical Science and EngineeringKAIST
2021.08.04 View 10856