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Prof. Cho Identifies Dynamics of Signal Transportation System in Control of Cell Proliferation
KAIST, Jan. 22, 2009 -- A research team led by Prof. Kwang-Hyun Cho of the Department of Bio and Brain Engineering, KAIST, has identified a hidden mechanism of the dynamic behavior of signal transportation system involved in the control of cell proliferation, university authorities said.
The finding is expected to provide a clue to appropriately controlling the pathway of ERK protein which is known to play a significant role in causing and spreading cancer. The research was featured as the cover paper of the latest online edition of the Journal of Cell Science.
The Ras-Raf-MEK-ERK pathway (or ERK pathway) is an important signal transduction system involved in the control of cell proliferation, survival and differentiation. However, the dynamic regulation of the pathway by positive- and negative-feedback mechanism, in particular the functional role of Raf kinase inhibitor protein (RKIP) are still incompletely understood. RKIP is a physiological endogenous inhibitor of MEK phosphorylation by Raf kinases, but also participates in a positive-feedback loop in which ERK can inactivate RKIP.
"We attempted to unearth the hidden dynamics of these feedback mechanisms and to identify the functional role of RKIP through combined efforts of biochemical experiments and computer simulations based on an experimentally validated mechanical model," Prof. Cho was quoted as saying.
2009.02.03 View 11191 -
Prof. Seong Publishes English Book on Reliability in Digital Control Systems
Prof. Poong-Hyun Seong of Department of Nuclear and Quantum Engineering has recently published an English-language book on reliability and risk issues in large scale safety-critical digital control systems used in complex facilities such as nuclear power plants.
The book entitled “Reliability and Risk Issues in Large Scale Safety-critical Digital Control Systems” is a result of Prof. Seong’s collaboration with some KAIST graduates who used to be under his guidance. The 303-page publication has been published by Springer, one of the world’s leading publishers of academic journals, as part of the Springer Series in Reliability Engineering.
The book consists of four parts; part I deals with issues related to hardware, part II software, part III human factors and finally the last part integrated systems. It can be purchased through some on-line book stores such as Amazon.com.
Prof. Seong served as an editor-in-chief for Nuclear Engineering and Technology (NET), an international journal of Korean Nuclear Society (KNS), from 2003 to 2008. He also worked as a chair of the Human Factors Division (HFD) of American Nuclear Society (ANS) from 2006 to 2007. Prof. Seong is now a commissioner of Korea Nuclear Safety Commission which is the nation’s highest committee on Nuclear Safety.
2008.12.26 View 15064 -
Prof. Cho Wins Best Paper Award
KAIST Prof. Nam-Zin Cho of the Department of Nuclear and Quantum Engineering, won the Best Thesis Award in the nuclear reactor physics category at the 2008 Winter Meeting of the American Nuclear Society held on Nov. 9-13 in Reno, Nevada.
His paper, entitled "Thermal Feedback Transient Analysis of a Pebble Fuel Based on the Two-Temperature Homogenized Model," was jointly authored by Hwi Yu and Jong-Un Kim under the guidance of Prof. Cho.
Prof. Cho was elected a fellow of the American Nuclear Society in 2001 and has served as the deputy editor of the Nuclear Science and Engineering, the research journal of the American Nuclear Society, since 1999.
2008.12.09 View 13346 -
Prof. Kim's Team Wins Silver Prize at International Design Contest
A KAIST team led by Prof. Myung-Suk Kim of the Department of Industrial Design won a silver prize (given by the Mayor of Osaka) at the 17th International Design Competition held at the Osaka International Convention Center on Nov. 27.
The team, made up of KAIST students Da-Woon Chung (representative), Ji-Hoon Kim and Bo-Yeon Kim, presented a sonic energy absorbing (SONEA) system to transform noise energy into electrical energy. At the 2008 competition held under the main theme of "Earth-Life: Clean Aqua, Clean Air, Clean Energy," a Chinese team won the gold prize, Japanese and Korean groups shared silver prizes, and bronze prizes were given to U.S. and German contestants.
It was noteworthy that the KAIST team was the only undergraduate contestants who won the prize. Ji-hoon Kim had already won a bronze prize last year at the same competition.
The International Design Competition Osaka has been held annually or biannually, organized by the Japan Design Foundation, since 1983 and is considered as one of the most prestigious design competitions.
2008.12.09 View 14505 -
Two KAIST Professors Elected Fellows of APS
Profs. Sung-Chul Shin and Chang-Hee Nam of the Department of Physics, KAIST, have recently been elected the 2009 fellows of the American Physical Society (APS), university officials said on Tuesday (Dec. 2).
The APS fellowship is a prestigious recognition of the two professors" outstanding academic achievements in the field of physics, the officials said. The selection criteria are known to be extremely stringent and only a small fraction of APS members become fellows.
Prof. Shin was cited for his pioneering contributions to the understanding of magnetization reversal dynamics, in particular critical scaling behavior of Barkhausen avalanches of 2D ferromagnets, and discovery of novel magnetic thin films and multilayers for high-density data storage.
Prof. Nam was recognized for his contributions to the theory and experiments of physical processes of high harmonic generation for the development of attosecond coherent x-ray sources and related femtosecond laser technology.
The American Physical Society, founded in 1899, is the world"s second largest organization of physicists, behind the Deutsche Physikalische Gesellschaft. It has 46,000 members across the world.
2008.12.04 View 13169 -
Prof. Kwon Unveils Home-Made Lunar Module
A KAIST research team led by Prof. Se-Jin Kwon at the Department of Aerospace Engineering has unveiled a small lunar module developed in cooperation with engineers at a local company, Space Solutions, university authorities said on Thursday (Nov. 27).
The home-made lunar module, the vehicle that conducts survey on the surface of the moon, is 40 centimeters tall and weighs 25 kg. Equipped with a liquid-fuel rocket engine with a maximum thrust of 350 newtons (N), it is capable of carrying objects weighing around 20 kg to the lunar space from the space ship. Professor Kwon"s team held a demonstration of the lander for journalists at a KAIST lab on Friday (Nov. 28).
Lunar landers are critical in developing lunar spacecraft, and countries with advanced aerospace technologies have been careful to protect their core technologies.
According to Prof. Kwon, every part of the rocket engine, including the catalyst, was home made. The rocket"s propulsion system features a state-of-the-art propellant valve developed by Space Solutions, which enables thrust control.
Lunar modules between the 100 and 200 kilogram range, developed by NASA (U.S. National Aeronautics and Space Administration), costs around $100 million, said Kwon. "It is expensive to guarantee the safety of developers of an American module because the fuel contains carcinogens. But the rocket engine created by KAIST team could cut development costs to about half that because it is powered by environmentally friendly fuel," he said.
The lander, product of a six-year-long effort, represents remarkable advancement in the technology for developing spacecraft for lunar missions.
2008.12.01 View 11314 -
2008 IEEE International Conference on Humanoid Robots Opens
The 2008 IEEE-RAS International Conference on Humanoid Robots, an international gathering to identify new research trends and technology in humanoid robotics, will open a three-day session on Monday (Dec. 1) at the Hotel Rivera and KAIST in Daejeon.
The annual conference is organized by KAIST and the Robotics and Automation Society of the Institute for Electric and Electronic Engineers, a U.S.-based international non-profit, professional organization for the advancement of technology related to electricity.
The conference is expected to draw a total of 200 robotics researchers from 19 different countries. Prof. Jun-Ho Oh, at the Department of Mechanical Engineering who led the creation of Korea"s first humanoid robot Hubo, is serving as general chair of the conference. Prof. Oh was named the host of the 2008 conference at the 2007 conference held at the Carnegie Melon University of the United States. The eight-year old conference was inaugurated in Boston in 2000.
On the opening day of Dec. 1, seven lectures will be given on diverse areas of robotics including cognitive humanoid vision, and robot vision sensor and sensing. On the subsequent two days, a total of 110 papers will be presented.
During the conference period, a variety of robots produced by six local and foreign robot makers will be on demonstration, providing opportunities for researchers and industrial robot makers to share technological ideas.
Highlights of the conference will be special lectures by world-renowned robot researchers Prof. Yoshiyuki Sankai of University of Tsukuba, who has created an exoskeletal "robot suit," and Prof. Art Kuo of Univerity of Michigan who is regarded as a leading authority in dynamic walking.
Following the conference, all participants are scheduled to tour Prof. Oh"s Hubo Lab and the Human-Robot Interaction Research Center, both located at KAIST.
2008.12.01 View 12777
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KAIST Collaborating with U.S. Universities to Advance Humanoid Robotics
Hubo, a life-size walking bipedal humanoid robot, is perhaps the best-known character in Korea that KAIST has ever produced. It was shown to the government heads of the Asia-Pacific region during the APEC held in Busan, Korea, in 2005 and appeared at the hit concerts of the pop singer Jang-Hoon Kim. The humanoid robot is soon likely to catch the fancy of Americans as a U.S. government-funded project seeks to create a Hubo that can work and interact with people in collaboration with Korean scientists.
"We are going to give the brains to Hubo. (Japanese) Asimo can do only pre-programmed actions. We want to create a Hubo that can help people, interact with people," said Prof. Paul Oh of the Department of Mechanical Engineering & Mechanics at Drexel University in Philadelphia and leader of the five-year international project which was launched in November 2007.
The U.S.$2.5 million project is funded through the Partnership for International Research and Education (PIRE) Program of the National Science Foundation (NSF) of the United States. It brings together world-renowned experts in humanoid design and information technologies.
"Dr. Jun-Ho Oh"s lab at KAIST (that has created Hubo) is the world"s leader in humanoid design and the U.S. has advanced technologies in the areas such as artificial intelligence, mechanical learning and robot vision. Combining the strengths of the two countries can create a synergy effect and develop a more advanced humanoid robot," said Paul Oh. He is currently serving as Program Director of Robotics of the NSF which is overseeing robotics research (non-military) in the U.S. consisting over 150 robotics faculty.
Paul Oh"s research team consists of experts from five U.S. universities -- Drexel, Bryn Mawr College, Colby College, the University of Pennsylvania and Virginia Tech -- and KAIST.
Leading a delegation of six professors and eight students, Dr. Paul Oh made a two-day visit to KAIST on Nov. 18-19 to review the progress of the project and have a technical meeting with participants.
"The U.S. universities participating in this program are scattered across the nation. So we decided to have a technical meeting here in Korea," he said.
Asked the reason why he chose KAIST as a partner for the program, Dr. Oh said that KAIST is willing to open Hugo to international researchers, whereas in Japan only Honda engineers are allowed to touch Asimo, which is a humanoid robot created by Honda Motor Company.
The project is to establish no barrier for roboticists anywhere in the world to pursue the humanoid research; a suite of humanoid platforms will be available for researchers to develop and advance capabilities like locomotion and human-robot interaction.
The team has been initially involved in development of three tools, all of which are based on the Hubo platform, in order to kick-start humanoid research in the U.S. They are the Mini-Hubo (a small, light-weight and affordable humanoid purchasable at the price lower than $8,000), On-Line Hubo (a program to operate Hubo online) and Virtual Hubo (a simulation program to do researches in cyberspace). As the first outcome of the project, the Mini-Hubo is expected to be released in the U.S. around next April.
Another important purpose of the PIRE program is to seek transformative models to train scientists and engineers to effectively work in global multi-disciplined design teams. To this end, an aggregate number of 20 students from U.S. universities are to stay at the KAIST during the next five years, with two students taking turns on a six-month term.
"I was really amazed how much work is done with small funding here. This is really an excellent example to learn," said Roy Gross, an undergraduate from Drexel who has been staying at Prof. Oh"s Lab for the past three months.
2008.11.21 View 16439 -
Method to Synthesize New Lithium Ion Battery Cathode Material Identified
A KAIST research team headed by Prof. Do-Kyung Kim at the Department of Materials Science and Engineering developed a technology to synthesize a new lithium ion battery spinel cathode which is regarded as a core part of hybrid and lithium battery cars.
The research was conducted in collaboration with a research team of Prof. Yi Cui at Stanford University"s Department of Chemistry. Their findings were introduced in the November issue of Nano Letters, one of the leading academic journals in nano-science.
The newly synthesized lithium ion battery spinel cathode known as spinel LiMn2O4 nanorods is attracting interests as an alternative cathode material since it is a low-cost, environmentally friendly substance for Li-ion battery cathodes. Its raw material is also highly available.
Lithium ion batteries with high energy and power density are important for consumer electronic devices, portable power tools, and vehicle electrification. LixCoO2 is a commonly used cathode material in commercial lithium iron batteries. However, the high cost, toxicity, and limited abundance of cobalt have been recognized to be disadvantageous.
2008.11.20 View 11844 -
KAIST Opens Cell Bench Research Center
KAIST opened a cell bench research center on the campus on Monday, Nov. 17, as a joint project with Samsung Electric Co. and Samsung Medical Center.
On hand at the opening ceremony were about 100 persons from the three organizations, including KAIST President Nam-Pyo Suh, Samsung Electric"s Chief Technology Officer (CTO) Byung-Cheon Koh and Samsung Medical Center Vice President Hyo-Geun Lim.
The newly-opened research center will be involved in the development of individually-tailored anti-cancer medicine using bio-inspired cell chips and technologies for clinical applications. Prof. Young-Ho Cho of the Department of Bio and Brain Engineering was named director of the research center.
"Top-notch professionals from the electronic industry, academia and the medical community have gathered together to establish this research center. We expect the center will open a new path for the science and technology community and the industry to combine their strengths and develop innovative anti-cancer therapeutics," said KAIST President Nam-Pyo Suh at the opening ceremony.
"The development of bio-cell chip technology represents a new challenge for the Samsung Electric which has focused on information technologies thus far. Through cooperation with KAIST and Samsung Medical Center, we expect to be able to develop a simple and efficient cure for cancer patients," commented Samsung Electric CTO Byung-Cheon Koh.
The research center will be initially concentrating on the development of cell chips for lung cancer, one of the primary causes of death for Koreans.
2008.11.17 View 14894 -
KAIST Research Team Unveils Method to Fabricate Photonic Janus Balls
A research team led by Prof. Seung-Man Yang of the Department of Chemical and Biomolecular Engineering has found a method to fabricate photonic Janus balls with isotropic structural colors.
The finding draws attention since the newly-fabricated photonic balls may prove useful pigments for the realization of e-paper or flexible electronic displays.
The breakthrough was published in the Nov. 3 edition of the science journal "Advanced Materials." The Nov. 6 issue of "Nature" also featured it as one of the research highlights under the title of "Future Pixels."
Prof. Yang"s research team found that tiny marbles, black on one side and colored on the other, can be made by "curing" suspensions of silica particles with an ultraviolet lamp. When an electric field is applied, the marbles line up so that the black sides all face upwards, which suggests they may prove useful pigments for flexible electronic displays.
The researchers suspended a flow of carbon-black particles mixed with silica and a transparent or colored silica flow in a resin that polymerizes under ultraviolet light. They then passed the mixture through a tiny see-through tube. The light solidified the silica and resin as balls with differently colored regions, each about 200 micrometers in diameter.
Over the last decades, the development of industrial platforms to artificially fabricate structural color pigments has been a pressing issue in the research areas of materials science and optics. Prof. Yang, who is also the director of the National Creative Research Initiative Center for Integrated Optofluidic Systems, has led the researches focused on fabrication of functional nano-materials through the process of assembling nano-building blocks into designed patterns.
The "complementary hybridization of optical and fluidic devices for integrated optofluidic systems" research was supported by a grant from the Creative Research Initiative Program of the Ministry of Education, Science & Technology.
2008.11.12 View 13018 -
KAIST Team Identifies Nano-scale Origin of Toughness in Rare Earth-added Silicon Carbide
A research team led by Prof. Do-Kyung Kim of the Department of Materials Science and Engineering of KAIST has identified the nano-scale origin of the toughness in rare-earth doped silicon carbide (RE-SiC), university sources said on Monday (Oct. 6).
The research was conducted jointly with a U.S. team headed by Prof. R. O. Ritchie of the Department of Materials Science and Engineering, University of California, Berkeley.
The findings were carried in the online edition of Nano Letters published by the American Chemical Association.
Silicon carbide, a ceramic material known to be one of the hardest substances, are potential candidate materials for many ultrahigh-temperature structural applications. For example, if SiC, instead of metallic alloys, is used in gas-turbine engines for power generation and aerospace applications, operating temperatures of many hundred degrees higher can be obtained with a consequent dramatic increase in thermodynamic efficiency and reduced fuel consumption. However, the use of such ceramic materials has so far been severely limited since the origin of the toughness in RE-SiC remained unknown thus far.
In order to investigate the origin of the toughness in RE-SiC, the researchers attempted to examine the mechanistic nature of the cracking events, which they found to occur precisely along the interface between SiC grains and the nano-scale grain-boundary phase, by using ultrahigh-resolution transmission electron microscopy and atomic-scale spectroscopy. The research found that for optimal toughness, the relative elastic modulus across the grain-boundary phase and the interfacial fracture toughness are the most critical material parameters; both can be altered with appropriate choice of rare-earth elements.
In addition to identifying the nano-scale origin of the toughness in RE-SiC, the findings also contributed to precisely predicting how the use of various rare-earth elements lead to difference in toughness.
University sources said that the findings will significantly advance the date when RE-SiC will replace metallic alloys in gas-turbine engines for power generation and aerospace applications.
2008.10.08 View 13944