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Nature Biotechnology Nominates Sang Yup Lee of KAIST for Top 20 Translational Researchers of 2014
Nature Biotechnology, recognized as the most prestigious journal in the field of biotechnology, has released today its list of the Top 20 Translational Researchers of 2014. Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering at KAIST (Korea Advanced Institute of Science and Technology) ranked seventh in the list. He is the only Asian researcher listed.
The journal, in partnership with IP Checkups, a patent analytics firm, presents an annual ranking of researchers based on their paper and patent output. The list includes, among others, each researcher’s most-cited patent in the past five years and their H index, a measurement to evaluate the impact of a researcher’s published work utilizing citation analysis. (More details can be found at http://www.nature.com/bioent/2015/150801/full/bioe.2015.9.html.)
American institutions made up the majority of the list, with 18 universities and research institutes, and the remainder was filled by KAIST in Korea and the Commonwealth Scientific and Industrial Research Organization (CSIRO) in Australia.
Globally known as a leading researcher in systems metabolic engineering, Professor Lee has published more than 500 journal papers and 580 patents. He has received many awards, including the Citation Classic Award, Elmer Gaden Award, Merck Metabolic Engineering Award, ACS Marvin Johnson Award, SIMB Charles Thom Award, POSCO TJ Park Prize, Amgen Biochemical Engineering Award, and the Ho Am Prize in Engineering.
2015.08.27 View 8861 -
A Technology Holding Company Establishes Two Companies Based on Technologies Developed at KAIST
Mirae Holdings is a technology holding company created by four science and technology universities, KAIST, DIGIST (Daegu Gyeongbuk Institute of Science and Technology), GIST (Gwangju Institute of Science and Technology), and UNIST (Ulsan National Institute of Science and Technology) in 2014 to commercialize the universities’ research achievements. The company identifies promising technologies for commercialization, makes business plans, establishes venture capitals, and invests in startup companies.
Over the past year, Mirae Holdings has established two venture companies based on the technologies developed at KAIST. In September 2014, it founded Cresem Inc., a company used the anisotropic conductive film (ACF) bonding technology, which was developed by Professor Kyung-Wook Paik of the Material Science and Engineering Department at KAIST. Cresem provides a technology to bond electronic parts ultrasonically. The company is expected to have 860,000 USD worth of sales within the first year of its launching.
Last June, Mirae Holdings created another company, Doctor Kitchen, with the technology developed by Professor Gwan-Su Yi of the Bio and Brain Engineering Department at KAIST. Doctor Kitchen supplies precooked food, which helps diabetic patients regulate their diet. The company offers a personalized diet plan to customers so that they can effectively manage their disease and monitor their blood sugar level efficiently.
The Chief Executive Officer of Mirae Holdings, Young-Ho Kim, said, “We can assist KAIST researchers who aspire to create a company based on their research outcomes through various stages of startup services such as making business plans, securing venture capitals, and networking with existing businesses.”
Young-Ho Kim (left in the picture), the Chief Executive Officer of Mirae Holdings, holds a certificate of company registration with Sang-Min Oh (right in the picture), the Chief Executive Officer of Cresem.
Young-Ho Kim (left in the picture), the Chief Executive Officer of Mirae Holdings, holds a certificate of company registration with Jae-Yeun Park (right in the picture), the Chief Executive Officer of Dr. Kitchen.
2015.07.29 View 10949 -
KAIST Researchers Develops Hyper-Stretchable Elastic-Composite Energy Harvester
A research team led by Professor Keon Jae Lee (http://fand.kaist.ac.kr) of the Department of Materials Science and Engineering at KAIST has developed a hyper-stretchable elastic-composite energy harvesting device called a nanogenerator.
Flexible electronics have come into the market and are enabling new technologies like flexible displays in mobile phone, wearable electronics, and the Internet of Things (IoTs). However, is the degree of flexibility enough for most applications? For many flexible devices, elasticity is a very important issue. For example, wearable/biomedical devices and electronic skins (e-skins) should stretch to conform to arbitrarily curved surfaces and moving body parts such as joints, diaphragms, and tendons. They must be able to withstand the repeated and prolonged mechanical stresses of stretching. In particular, the development of elastic energy devices is regarded as critical to establish power supplies in stretchable applications. Although several researchers have explored diverse stretchable electronics, due to the absence of the appropriate device structures and correspondingly electrodes, researchers have not developed ultra-stretchable and fully-reversible energy conversion devices properly.
Recently, researchers from KAIST and Seoul National University (SNU) have collaborated and demonstrated a facile methodology to obtain a high-performance and hyper-stretchable elastic-composite generator (SEG) using very long silver nanowire-based stretchable electrodes. Their stretchable piezoelectric generator can harvest mechanical energy to produce high power output (~4 V) with large elasticity (~250%) and excellent durability (over 104 cycles). These noteworthy results were achieved by the non-destructive stress- relaxation ability of the unique electrodes as well as the good piezoelectricity of the device components. The new SEG can be applied to a wide-variety of wearable energy-harvesters to transduce biomechanical-stretching energy from the body (or machines) to electrical energy.
Professor Lee said, “This exciting approach introduces an ultra-stretchable piezoelectric generator. It can open avenues for power supplies in universal wearable and biomedical applications as well as self-powered ultra-stretchable electronics.”
This result was published online in the March issue of Advanced Materials, which is entitled “A Hyper-Stretchable Elastic-Composite Energy Harvester.”
YouTube Link: “A hyper-stretchable energy harvester”
https://www.youtube.com/watch?v=EBByFvPVRiU&feature=youtu.be
Figure: Top row: Schematics of hyper-stretchable elastic-composite generator enabled by very long silver nanowire-based stretchable electrodes.
Bottom row: The SEG energy harvester stretched by human hands over 200% strain.
2015.04.14 View 12837 -
KAIST Introduces New UI for K-Glass 2
A newly developed user interface, the “i-Mouse,” in the K-Glass 2 tracks the user’s gaze and connects the device to the Internet through blinking eyes such as winks. This low-power interface provides smart glasses with an excellent user experience, with a long-lasting battery and augmented reality.
Smart glasses are wearable computers that will likely lead to the growth of the Internet of Things. Currently available smart glasses, however, reveal a set of problems for commercialization, such as short battery life and low energy efficiency. In addition, glasses that use voice commands have raised the issue of privacy concerns.
A research team led by Professor Hoi-Jun Yoo of the Electrical Engineering Department at the Korea Advanced Institute of Science and Technology (KAIST) has recently developed an upgraded model of the K-Glass (http://www.eurekalert.org/pub_releases/2014-02/tkai-kdl021714.php) called “K-Glass 2.”
K-Glass 2 detects users’ eye movements to point the cursor to recognize computer icons or objects in the Internet, and uses winks for commands. The researchers call this interface the “i-Mouse,” which removes the need to use hands or voice to control a mouse or touchpad. Like its predecessor, K-Glass 2 also employs augmented reality, displaying in real time the relevant, complementary information in the form of text, 3D graphics, images, and audio over the target objects selected by users.
The research results were presented, and K-Glass 2’s successful operation was demonstrated on-site to the 2015 Institute of Electrical and Electronics Engineers (IEEE) International Solid-State Circuits Conference (ISSCC) held on February 23-25, 2015 in San Francisco. The title of the paper was “A 2.71nJ/Pixel 3D-Stacked Gaze-Activated Object Recognition System for Low-power Mobile HMD Applications” (http://ieeexplore.ieee.org/Xplore/home.jsp).
The i-Mouse is a new user interface for smart glasses in which the gaze-image sensor (GIS) and object recognition processor (ORP) are stacked vertically to form a small chip. When three infrared LEDs (light-emitting diodes) built into the K-Glass 2 are projected into the user’s eyes, GIS recognizes their focal point and estimates the possible locations of the gaze as the user glances over the display screen. Then the electro-oculography sensor embedded on the nose pads reads the user’s eyelid movements, for example, winks, to click the selection. It is worth noting that the ORP is wired to perform only within the selected region of interest (ROI) by users. This results in a significant saving of battery life. Compared to the previous ORP chips, this chip uses 3.4 times less power, consuming on average 75 milliwatts (mW), thereby helping K-Glass 2 to run for almost 24 hours on a single charge.
Professor Yoo said, “The smart glass industry will surely grow as we see the Internet of Things becomes commonplace in the future. In order to expedite the commercial use of smart glasses, improving the user interface (UI) and the user experience (UX) are just as important as the development of compact-size, low-power wearable platforms with high energy efficiency. We have demonstrated such advancement through our K-Glass 2. Using the i-Mouse, K-Glass 2 can provide complicated augmented reality with low power through eye clicking.”
Professor Yoo and his doctoral student, Injoon Hong, conducted this research under the sponsorship of the Brain-mimicking Artificial Intelligence Many-core Processor project by the Ministry of Science, ICT and Future Planning in the Republic of Korea.
Youtube Link:
https://www.youtube.com/watchv=JaYtYK9E7p0&list=PLXmuftxI6pTW2jdIf69teY7QDXdI3Ougr
Picture 1: K-Glass 2
K-Glass 2 can detect eye movements and click computer icons via users’ winking.
Picture 2: Object Recognition Processor Chip
This picture shows a gaze-activated object-recognition system.
Picture 3: Augmented Reality Integrated into K-Glass 2
Users receive additional visual information overlaid on the objects they select.
2015.03.13 View 15490 -
KAIST and Petersburg State Transport University Sign a MOU on Green Transportation
The Petersburg State Transport University (PSTU) in Russia is a higher education institution specializing in railway transport.
KAIST and PSTU signed a memorandum of understating (MOU) on October 28, 2014 at the KAIST campus and agreed to collaborate in the research of and hold academic exchanges for green transportation.
Based on the agreement, the two institutions will collaborate in the development of a high capacity railway that is powered through wireless power transfer technology and will exchange personnel and academic knowledge to advance the field of green transportation.
The Graduate School for Green Transportation (GSGT) at KAIST organized a seminar which took place after the MOU signing ceremony. Professor Dong-Ho Cho, the Dean of GSGT, presented a keynote speech at the seminar on “Korea’s Green Transportation Policy and Its Technology Development Status” to the audience including the PSTU delegation.
Established in 1809, PSTU is one of the oldest and most prestigious engineering universities in Russia, serving as an important scientific and research center in the area of engineering, construction, and railway operation.
2014.11.04 View 8371 -
Artificial Antibody-based Therapeutic Candidate for Lung Cancer Developed
Professor Hak-Sung Kim of Biological Sciences at KAIST publishes a cover article on artificial antibody in "Molecular Therapy".
Repebody-based lung cancer therapeutic drug candidate developed Repebody-based protein demonstrates the possibility of the development of a new drug
KAIST Biological Sciences Department’s Professor Hak-Sung Kim, in collaboration with Professor Eun-Kyung Cho from the College of Medicine at Chungnam National University, has successfully developed an artificial antibody-based, or repebody, cancer therapeutic candidate. These research results were published as a cover paper of the July edition of Molecular Therapy.
The repebody developed by Professor Kim and his team strongly binds to interleukin-6, a cancer-causing factor. It has also been confirmed that the repebody can significantly inhibit the proliferation of cancer cells in non-small-cell lung cancer animal model.
Numerous multinational pharmaceutical and biotechnology companies have invested astronomical amounts of money in research for the development of protein therapeutics with low side effects and high efficacy. More than 20 kinds of such therapeutics are currently under clinical trials, and over 100 drugs are under clinical demonstration. Among these, the majority is antibody-based therapeutics, and most of the investments are heavily concentrated in this field. However, antibody production cost is very high because it has large molecular weights and complex structural properties, and this makes it difficult to engineer. Consequently, the development costs a great deal of time and money.
In order to overcome the existing limitations of antibody-based therapeutics, Professor Kim and his team have developed a new artificial antibody, or repebody, which was published in Proceedings of the National Academy of Sciences (PNAS) in 2012. Based on this research, they have succeeded in developing a therapeutic candidate for treating non-small-cell lung cancer with a specifically strong cohesion to the cancer-causing factor, interleukin-6.
Interleukin-6 is a crucial substance within the body that is involved in immune and inflammatory-related signals. When abnormally expressed, it activates various carcinogenic pathways and promotes tumor growth and metastasis. Because of its importance, multinational pharmaceutical companies are heavily investing in developing therapeutics that can inhibit the signaling of interleukin-6.
In this study, Professor Kim and his team observed that a repebody consists of repeated modules, and they conceived a module-based affinity amplification technology that can effectively increase the binding affinity with the disease target. The developed therapeutic candidate has been confirmed in cell and animal experiments to show low immunogenicity, as well as to strongly inhibit the proliferation of non-small-cell lung cancer.
Furthermore, by investigating the complex structure of the repebody with interleukin-6, Professor Kim has identified its mechanism, which demonstrated the potential for therapeutic development. The researchers are currently carrying out pre-clinical trials for acquiring permission to perform clinical trials on animals with non-small-cell lung cancer. The repebody can be developed into a new protein drug after demonstrating its safety and efficacy.
Professor Hak-Sung Kim and his team have confirmed that the repebody can be utilized as a new protein drug, and this will be a significant contribution to Korea’s protein drugs and biotechnology industry development.
The research was supported by the Future Pioneer Industry project and sponsored by the Ministry of Science, ICT and Future Planning.
Figure 1. Professor Kim’s article published as the cover article of July edition of Molecular Therapy
Figure 2. Clinical proof of the repebody’s inhibition of cancer growth using animal models
2014.07.14 View 12113 -
Establishment Agreement for KAIST-Poongsan Future Technology Research Center
KAIST and Poongsan Corporation agreed to found the KAIST-Poongsan Future Technology Research Center and held a ceremony to sign a memorandum of understanding in front of 30 attendees including KAIST President Steve Kang and Poongsan Chairman Jin Ryu on May 27 at KAIST.
The Research Center will develop basic technology in the fields of defense and high tech materials as well as build a new foundation for future Poongsan projects. Research areas include technologies for new materials, propulsion control, and defense.
To further this endeavor, Poongsan Corporation will support the KAIST-Poongsan Future Technology Research Center for 3 years through an investment of USD 2.95 million, personnel, and technology.
An agreement was made between KAIST and Poongsan to establish the Future Technology Research Center.
2014.05.29 View 7370 -
KAIST leaps to 2nd place in 2014 QS Asian University Rankings
The highest record ever made by a Korean university since the rankings were published in 2009
KAIST jumped four places to rank #2 from #6 last year, following the National University of Singapore
In the "2014 Quacquarelli Symonds (QS) University Rankings: Asia," KAIST advanced four places compared to 2013 and was ranked 2nd best university in Asia.
QS, an English institution for global university evaluation, and Chosun Newspaper, a leading daily newspaper in Korea, announced the results of the QS Asia University Rankings on April 12th. The result was a record high for a Korean University since the start of annual rankings in 2009.
KAIST has consistently ranked within the top ten, ranking 7th in 2009 and 2012, and 6th in 2013. The sudden jump from the 6th to the 2nd place was attributed to the increase in the number of published papers per professor and the number of citations per paper. In particular, KAIST received high marks for research contributions, which shows that the young faculty members hired since 2006 is now becoming very productive.
For details regarding the 2014 QS University Rankings: Asia, please visit
http://www.topuniversities.com/university-rankings-articles/asian-university-rankings/top-10-universities-asia-2014.
President Steve Kang of KAIST commented, “We are reaping the rewards of recruiting some of the most promising young professors. KAIST will continue its development towards becoming one of the top ten universities in the world.”
The QS Asia University Rankings have evaluated higher education institutions of Asia for the past six years. It evaluates 491 universities across 17 nations. Criterion for evaluation includes academic evaluation (30%), number of published papers per staff (15%), citation frequency (15%), number of students per staff (20%), alumni reputation, and internationalization (10%).
Please also refer to the Korean-American Science and Technology News (KASTN), dated June 4, 2014, for further information on the rankings.
Another Rankings, Pages 4-5
Chosun Ilbo, May 12, 2014
“Chosun-QS Rankings”
KAIST Soars to 2nd Place in Asian Rakings
http://www.phy.duke.edu/~myhan/b_14-12.pdf
2014.05.14 View 12900 -
Times Higher Education 2014 World Reputation Rankings
Times Higher Education released the 2014 World Reputation Rankings on March 6, 2014. KAIST moved from the 61-70 band in 2013 to the 51-60 place this year. For details, please visit the link below:
http://www.scoop.co.nz/stories/WO1403/S00091/times-higher-education-2014-world-reputation-rankings.htm
2014.03.07 View 6858 -
Quacquarelli Symonds (QS) World University Rankings by Subject 2014
The QS
World University Rankings are annual university rankings published by
Quacquarelli Symonds (QS) which provides the overall rankings of top global
universities as well as the rankings for individual subjects. The 2014 QS World
University Rankings by Subject is a comprehensive guide to the world’s best universities
in 30 popular subjects of 5 academic disciplines: arts & humanities,
engineering & technology, life sciences & medicine, natural sciences,
and social sciences.
According
to the 2014 subject rankings, released on February 26, KAIST made the list of top
50 universities in 9 subjects: physics & astronomy; materials sciences;
chemistry; chemical engineering; mechanical, aeronautical & manufacturing
engineering; electrical & electronic engineering; civil & structural engineering;
computer science & information systems; and biological sciences.
Among
them, KAIST was ranked number one in Korea for 5 subjects: materials sciences
(16th); mechanical, aeronautical & manufacturing engineering (21st);
civil & structural engineering (32nd); computer science &
information systems (36th), and biological sciences (43rd).
For basic sciences, KAIST has made good progress as well. For example, in
mathematics, KAIST took first place in Korea and was ranked in the 51st-100th
of the world’s top universities. Another notable result was that its business college
in Seoul campus, a relatively new addition to KAIST, made the rankings list of
51st-100th in accounting & finance.
The 2014
QS subject rankings used the following criteria for its evaluation of
university performance: a survey of academic and employer reputation, citations
per paper, inclusion of specialists, and the h-index, known as the Hirsch index or Hirsch number, which was
suggested by Jorge E. Hirsch, a physicist at the University of California in
San Diego, as a tool for determining theoretical physicists’ relative quality.
Today, the h-index is used to measure
both the productivity and impact of the published work of a scientist or
scholar.
2014.02.28 View 10378 -
The Huffington Post, January 30th, 2014: The Top Young Universities in the World, According to QS Rankings
KAIST was ranked third among the “QS Top 50 Under 50,” a ranking of the world’s top 50 universities established within the last 50 years, which was based on the highest performing young universities in the 2013/14 QS World University Rankings. For details, please read the news article below:
The Huffington Post, January 30th, 2014: The Top Young Universities in the World, According to QS Rankings: http://www.huffingtonpost.co.uk/2014/01/30/top-young-universities-in-world-qs-rankings_n_4693918.html
2014.02.03 View 5988 -
Materials Developed for Sodium Rechargeable Battery by EEWS
The research group of Professor William Goddard III, You-Sung Jung, and Jang-Wook Choi from the Graduate School of Energy, Environment, Water, and Sustainability (EEWS) at KAIST has developed a new sodium-ion rechargeable battery which operates at a high voltage, can be charged, and stably discharges over 10,000 cycles. The research results were published in the online version of the Proceedings of the National Academy of Sciences of the United States of America (PNAS) on December 30, 2013.
Since the material costs of sodium rechargeable batteries is 30 to 40 times lower than lithium batteries, it has received attention as an energy saving tool for smart grids and as the next generation of lithium rechargeable batteries. Until now, sodium-ion rechargeable batteries have had issues with stability when charging and discharging. The research group developed a vanadium-based electrode to solve these problems.
The group said follow-up research will be continued to develop advanced technology on sodium rechargeable batteries as it is still currently in the beginning stages.
The research team: From left to right is Professors William Goddard, You-Sung Jung, and Jang-Wook Choi
2014.01.13 View 9914