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The key to Alzheimer disease, PET-MRI made in Korea
Professor Kyu-Sung Cho
- Simultaneous PET-MRI imaging system commercialization technology developed purely from domestic technology - - Inspiring achievement by KAIST, National NanoFab Center, Sogang University, Seoul National University Hospital –
Hopes are high for the potential of producing domestic products in the field of state-of-the-art medical imaging equipment that used to rely on imported products.
The joint research team (KAIST, Sogang University and Seoul National University) with KAIST Department of Nuclear and Quantum Engineering Professor Kyu-Sung Cho in charge, together with National Nanofab Institution (NNFC; Director Jae-Young Lee), has developed PET-MRI simultaneous imaging system with domestic technology only. The team successfully acquired brain images of 3 volunteers with the newly developed system.
PET-MRI is integrated state-of-the-art medical imaging equipment that combines the advantages of Magnetic Resonance Imaging (MRI) that shows anatomical images of the body and Position Emission Tomography (PET) that analyses cell activity and metabolism. Since the anatomical information and functional information can be seen simultaneously, the device can be used to diagnose early onset Alzheimer’s disease and is essential in biological science research, such as new medicine development.
The existing equipment used to take MRI and PET images separately due to the strong magnetic field generated by MRI and combine the images. Hence, it was time consuming and error-prone due to patient’s movement. There was a need to develop PET that functions within a magnetic field to create a simultaneous imaging system.
The newly developed integral PET-MRI has 3 technical characteristics: 1. PET detector without magnetic interference, 2. PET-MRI integration system, 3.PET-MRI imaging processing.
The PET detector is the most important factor and accounts for half the cost of the whole system. KAIST Professor Cho and NNFC Doctor Woo-Suk Seol’s team successfully developed the Silicon Photomultiplier (amplifies light coming into the radiation detector) that can be used in strong magnetic fields. The developed sensor has a global competitive edge since it optimises semiconductor processing to yield over 95% productivity and around 10% gamma radiation energy resolving power.
Sogang University Department and Electrical Engineering Professor Yong Choi developed cutting edge PET system using a new concept of electric charge signal transmission method and imaging location distinction circuit. The creativity and excellence of the research findings were recognised and hence published on the cover of Medical Physics in June.
Seoul National University Hospital Department of Nuclear Medicine Professor Jae-Sung Lee developed the Silicon Photomultiplier sensor based PET imaging reconstitution programme, MRI imaging based PET imaging revision technology and PET-MRI imaging integration software.
Furthermore, KAIST Department of Electrical Engineering Professor Hyun-Wook Park was responsible for the development of RF Shielding technology that enables simultaneous installation of PET and MRI and using this technology, he developed a head coil for the brain that can be connected to PET for installation.
Based on the technology describe above, the joint research team successfully developed PET-MRI system for brains and acquired PET-MRI integrated brain images from 3 volunteers last June.
In particular, this system has the distinct feature of a detachable PET module and MRI head coil to the existing whole body MRI, so that PET-MRI simultaneous imaging is possible with low installation cost.
Professor Cho said, “We have prepared the foundation of domestic commercial PET and the system has a competitive edge in the global market of PET-MRI system technology.” He continued, “It can reduce the cost of the increasing brain related disease diagnosis, including Alzheimer’s, dramatically.”
Funded by Ministry of Trade, Industry and Energy as an Industrial Foundation Technology Development Project (98 billion won in 7 years), the research applied for over 20 patents and 20 CSI theses.
Figure 1.Brain phantom images from developed PET-MRI system
Figure 2. Brain images from developed PET-MRI system
Figure 3. Domestic PET-MRI clinical trial
Figure 4. Head RF coil and PET detector inserted in MRI
Figure 5. Insertion type PET detector module
Figure 6. Silicon Photomultiplier sensor (Left) and flash crystal block (right)
Figure7. Silicon Photomultiplier sensor
Figure 8. PET detection principle
2013.11.28 View 12479 -
Cambridge University Press and HISTAC to Publish Science and Civilization in Korea
The KAIST Research Institute for the History of Science, Technology and Civilization of Korea (HISTAC) and Cambridge University Press have agreed to publish a 10-volume collection entitled “Science and Civilization in Korea” in collaboration with the Needham Research Institute.
HISTAC was found in December 2012 with the support of the Academy of Korean Studies and the Korean Studies Promotion Service with the aim of publishing a collection composed of 30 Korean books and 7 English books on Korean science and civilization.
By November 2013, the HISTAC research team submitted a research paper composed of 11 Korean and 1 English book. It has now exceeded its initial goal of publishing 7 English books by signing the recent agreement with the Cambridge University Press.
“Science and Civilization in Korea” is the second collection of non-western science to be published by the Cambridge University Press since 1954 following “Science and Civilization in China” by Joseph Needham who is well-known for his momentous achievements in history of science in East Asia. This collection will highlight the achievements of Korea in science and civilization of Korea, much of which has been under-valued compared to those of China and Japan.[ It now has the significance similar to the Western science and civilization].
HISTAC appointed Professor Hong-Gi Yoon from the University of Auckland as the translator and invited Professor Christopher Cullen from Cambridge University and Professor Morris Low from the University of Queensland as co-editors. Professor Cullen was an editor of “Science and Civilization in China” and is now the director of the Needham Research Institute and Professor Low is an expert in modern science of East Asia.
The series includes:
- History of Science and Technology in Korea
- Technology, Everyday Life, and Korean Civilization
- History and Cultural Studies of Geomancy in Korea
- Patients, Doctors and the State: History of Korean Medical and Pharmaceutical Culture
- History of Astronomy in Korea
- Mathematics and the History of Korean Civilization
- The West and Korea in the History of Science and Technology, 1600-1950
- Imperialism, Colonialism, Post-colonialism and Technological Science in Korea
- Development of Science and Technology Under the Korean Authoritarian Regime
- Dynamics of Technological Development in Korean Industrialization
The HISTAC team believes that the publication will illuminate the nation’s triumphs in science and technology and expects that the publication will serve as valuable research resources for the study of the history of East Asian scientific civilization which has mainly focused on China and Japan. Further, by adopting various case studies of scientific achievements of South Korea and developing countries, they hope to propose a new model for studying history of science and civilization.
2013.11.28 View 8197 -
Green Technology for Data Centers: Ultra-low Power 100 Gbps Ethernet Integrated Circuit Developed
A new integrated circuit (IC), consuming only 0.75W of electricity, will reduce the power usage of data chips installed at data centers by one-third.
Each day, billions of people surf the Internet for information, entertainment, and educational content. The Internet contains an immeasurable amount of information and knowledge generated every minute all around the world that is readily available to everyone with a click of a computer mouse. The real magic of the Internet, however, lies in data centers, where hundreds of billions of data are stored and distributed to designated users around the clock.
Today, almost every business or organization either has its own data centers or outsources data center services to a third party. These centers house highly specialized equipment responsible for the support of computers, networks, data storage, and business security. Accordingly, the operational cost of data centers is tremendous because they consume a large amount of electricity.
Data centers can consume up to 100 times more energy than a standard office building. Data center energy consumption doubled from 2000 to 2006, reaching more than 60 billion kilowatt hours per year. If the current usage and technology trends continue, the energy consumption of data centers in the US will reach 8% of the country’s total electric power consumption by 2020.
A research team at the Korea Advanced Institute of Science and Technology (KAIST) and Terasquare, Inc. (
http://www.terasquare.co.kr
), a spin-off company of the university,
developed an extremely low-powered integrated circuit for Ethernet that consumes less than 0.75W of electricity but is able to send and receive data at the high speed of 100 gigabits per second (Gbps). The research team, headed by Hyeon-Min Bae, assistant professor of electrical engineering at KAIST, claims that the new microchip uses only one-third of the electricity consumed by the currently installed chips at data centers, thereby helping the centers to save energy.
Integrated circuits are embedded on communication modules that are inserted into a line card. Data centers have numerous line cards to build a network including routers and switches. Currently, 8W ICs are the most common in the market, and they consume a lot of energy and require the largest modules (112 cm
2
of CFP), decreasing the port density of line cards and, thus, limiting the amount of data transmission.
The ultra-low-power-circuit, 100-gigabit, full-transceiver CDR, is the world’s first solution that can be loaded to the smallest communication modules (20 cm
2
of CFP4 or 16 cm
2
of
QSFP28), the next-generation chips for data centers. Compared with other chip producers, the 100 Gbps CDR is a greener version of the technology that improves the energy efficiency of data centers while maintaining the high speed of data transmission.
Professor Hyeon-Min Bae said, “When we demonstrate our chip in September of this year at one of the leading companies that manufacture optical communication components and systems, they said that our product is two years ahead of those of our competitors. We plan to produce the chip from 2014 and expect that it will lead the 100 Gbps Ethernet IC market, which is expected to grow to USD 1 billion by 2017.”
The commercial model of the IC was first introduced at the 39
th
European Conference and Exhibition on Optical Communication (ECOC), the largest optical communication forum for new results and developments in Europe, held from September 22-26 at ExCeL London, an international exhibition and convention center.
Professor Bae added, “We received positive responses to our ultra-low-power 100-Gbps Ethernet IC at the ECOC. The chip will be used not only for a particular industry but also for many of next-generation, super-high-speed information communications technologies, such as high-speed USB, high-definition multimedia interface (HDMI), and TV interface.”
Before joining KAIST, Hyeon-Min Bae worked for many years at Finisar as a researcher who designed and developed the world’s first super-high-speed circuit, the 100 Gbps Ethernet IC.
2013.11.25 View 8526 -
Visit by the President of the University of Illinois at Urbana-Champaign, US
A delegation from the University of Illinois at Urbana-Champaign (UIUC) in the United States visited KAIST on November 11, 2013.
The delegation consisted of senior administrators from the university, the president, vice president for research, dean of engineering college, dean of nursing college, and associate chancellor for corporate and international relations. The managing director of the State of Illinois Far East Office also joined the delegation.
They met with President Steve Kang, including vice presidents and deans of KAIST, and discussed forming a possible partnership between KAIST and UIUC.
Robert A. Easter, the president of UIUC, said, “Higher education institutions today are bearing a critical responsibility to increase the awareness, knowledge, skills, and values needed to create a sustainable future. I hope KAIST and the University of Illinois will join forces to lead innovation in higher education and to stay connected and relevant in a global marketplace.”
President Steve Kang responded, “There would be many opportunities for the two universities to collaborate and achieve global preeminence in such field as biotechnology, engineering, and convergence research.”
The University of Illinois, with three distinct campuses in Chicago, Springfield, and Urbana-Champaign, is one of the most prestigious universities in the world. The university has an annual operating budget of more than USD 5 billion, collectively enrolls more than 78,000 students, awards nearly 20,000 degrees each year, and has more than 665,000 alumni around the world.
2013.11.18 View 7261 -
Professor Ji-Yun Lee, Received FAA Recognition Award
Professor Ji-Yun Lee, from the Department of Aerospace Engineering at KAIST, received the US Federal Aviation Administration (FAA) Recognition Award for her Ground-Based Augmentation System (GBAS) and her contribution to the development of satellite navigation technology.
GBAS contributes to the safety of aircraft navigation by providing flawless information with real-time location accuracy within one meter.
Professor Lee developed the monitoring software to improve the safety of GBAS users in her paper published in the International Journal of Radio Science in July of 2012.
The software will be distributed and used by many organizations including Eurocontrol following verification from the FAA technical center. It is expected to be standardized after discussions among international organizations.Professor Lee said, “As satellite navigation is applied to the infrastructure of air, marine, and ground transportation, as well as information & communications and finance, ensuring the performance and safety of the system is the most important factor. GBAS will be further developed and applied as a part of a global service system through international collaboration.”
2013.11.15 View 10197 -
2013 International Forum on Eco-Friendly Vehicle and System
Leaders in transportation technology gathered at KAIST to discuss commercialization & standardization and to encourage the exchange of research progress, strategy, and future initiatives in transportation technology.
The Graduate School for Green Transportation at KAIST hosted the 2013 International Forum on Eco-friendly Vehicles and Systems (IFEV) in Fusion Hall of the KAIST Institute Building from October 21 to 22.
About 50 leaders in the field of future transportation from academic institutes and industries including Dr. Soon-Man Hong, President of Korea Railroad Research Institute (KRRI), Dr. Kwang-Hee Nam, Professor at Pohang University of Science and Technology (POSTECH), and Mr. Mike Schagrin, the Intelligent Transportation Systems Program Manager of the US Department of Transportation (retired) participated in the 4th annual IFEV.
The commercialization & standardization session and a technical session were followed by the plenary meeting of the forum.
Dr. Hong, the keynote speaker, introduced the High Capacity Double Deck High Speed Train, Near Surface Subway System, and Urban Railway System with Wireless Power Transfer Technology under the title “Korea’s Policy and Technology Initiative for Enhancing Green Transport Systems.”
Dr. Kwang-Hee Nam presented “Electric Vehicle Trends & the POSTECH E-Car Research Center Power Train Design,” followed by Mr. Mike Schagrin who spoke about “Going Green with Connected Automation.”
Dr. Omer C. Onar from the Oak Ridge National Laboratory (ORNL) shared recent research on “ORNL Development in Stationary and Dynamic Wireless Charging.”
In the commercialization session, Faical Turki of Vahle, Germany, presented “Wireless Inductive Battery Chargers,” and Professor Kazuyuki Ouchi from Tokyo University presented “Wind Challenger, the Next Generation Hybrid Vessels.”
In the technical session, presentations and discussions were performed on future ground vehicles and railroad technology, intelligent transportation systems and strategy, and policy on eco-friendly vehicle technology, including Professor In-Soo Suh of the Graduate School for Green Transportation at KAIST who presented on “Armadillo-T: 4WD Micro Electric EV with a Foldable Body Concept.”
On the second day of IFEV 2013, representatives of the European Union’s Safe and Green Road Vehicles (SAGE) consortium discussed connectivity in road transportation as a means of improving safety, efficiency and convenience in future safe and green vehicles with collaboration from Korean transportation organizations such as the Korea Transport Institute and Electronics and Telecommunications Research Institute.
Professor Suh, who organized the forum, said, “This forum will serve as an excellent opportunity to discuss and share R&BD progress in the green transportation field. “Details can be found at http://gt.kaist.ac.kr/ifev2013/.
2013.11.15 View 11134 -
Professor Chun-Taek Rim Appointed as Associate Editor for IEEE TPEL
Professor Chun-Taek Rim of the nuclear and quantum engineering at KAIST was appointed as an associate editor of the Institute of Electrical and Electronics Engineers (IEEE) Transactions on Power Electronics (TPEL), an eminent academic journal bio-monthly published in the field of power electronics.The journal has a high impact factor (4.08), a measure reflecting the average number of citations to recent articles published in an academic journal, which ranks as the 6th the most influential journal among the 100 journals published by IEEE.Professor Rim was also appointed to an associate editor for IEEE Journal of Emerging and Selected Topics in Power Electronics in September in recognition of his expertise in wireless power and electric vehicles.
2013.11.15 View 9890 -
KAIST's Partnership Agreement with the Imperial College of Science, Technology and Medicine, UK
KAIST signed an agreement on academic and research cooperation with the Imperial College of Science, Technology (Imperial College London) and Medicine in the United Kingdom (UK) on November 6th, 2013 in London.
The two universities have been implementing collaboration programs at the department level in the areas of plastic electronics since September 2012 and systems engineering and molecular simulation since February 2013, but have never had a formal partnership agreement.
President Steve Kang from KAIST and Provost James Stirling from Imperial College London signed the comprehensive cooperation agreement which will not only strengthen the existing collaborations between the two institutions but also explore areas of mutual interest in the interdisciplinary study of big data, as well as in the fields of mechanical engineering, synthetic biology, and quantum physics.
Workshops, seminars, lectures, and conferences will be jointly organized and held to facilitate the exchange of research staff and faculty and to promote collaborations in research assignments. The universities will also look into the possibility of exchange programs for undergraduate and graduate students.
The partnership agreement will be effective for five years.
Minister Moon-Gi Choi from the Republic of Korea’s Ministry of Science, Information and Communications Technology (ICT) & Future Planning attended the signing ceremony as well and congratulated the establishment of the partnership, saying:
“We are living in the age of highly advanced science and technology that requires us to have a new economic development paradigm for sustainable growth. Through convergence research based on the application of ICT and technology innovation, we will have new opportunities for development. I hope KAIST and the Imperial College London will be at the forefront of such endeavors in coming years.”With its history spanning over 100 years, the Imperial College London is a public research university located in London, UK, specializing in science, engineering, medicine, and business. The university is regarded as being one of the most prestigious universities in the world, having eminent alumni such as Thomas Henry Huxley (biologist), H.G. Wells (author), and Sir Alexander Fleming (pharmacologist).
From left to right: Provost James Stirling, Minister Moon-Gi Choi, and President Steve Kang
2013.11.12 View 8472 -
Observation of a water strider led to a new method of measuring properties of Nano films
Even the mechanical properties of Nano films of a few nanometers thick can be measured
Posted online Nature Communications on the 3rd of October
The joint research team of KAIST’s Department of Mechanical Engineering’s Professor Taek-Soo Kim and Doctor Seung-Min Hyun of the Nano mechanics laboratory of Korea Institute of Machinery and Materials has developed a new method to evaluate mechanical properties of Nano films using the characteristics of water surfaces.
The research findings have been posted on the online edition of Nature Communications on the 3rd of October. The technology can obtain accurate results by directly measuring the mechanical properties such as the strength and elasticity of Nano films. Academia and the industry expect the simplicity of the technology to present a new paradigm in the evaluation of mechanical properties of Nano films.
Evaluation of the mechanical properties of Nano films is essential not only in predicting the reliability of semiconductors and displays, but also in finding new phenomena in the Nano world. However, mechanical strength was difficult to test since the test demands the falling of objects to the ground to measure their strength, and nano films can easily break in the process.
The research team observed insects such as water striders freely floating on the surface of the water. The team used the properties of water, large surface tension and low viscosity, to float a 55 nanometers (nm) gold Nano film to successfully measure its mechanical properties without damaging it. The technology could be used to measure the mechanical properties of not only various types of Nano films but also films only a few nm thick.
Professor Taek-Soo Kim said, “We effectively performed an evaluation of the mechanical characteristics of Nano films, which was difficult in the past, by developing a new strength test using the properties of water.” He continued to say, “The team plans to discover the mechanical properties of 2D Nano films such as graphene that could not have been measured with the existing strength test methods.”
The research by KAIST’s Department of Mechanical Engineering’s graduate student Jae-Han Kim (lead author) under the supervision of Professor Taek-Soo Kim and Doctor Seung-Min Hyun of Korea Institute of Machinery and Materials was sponsored by the National Research Foundation of Korea.
Evaluation process of mechanical properties of Nano films by using the characteristics of water surfaces
Dr Seung-Min Hyun, Jae-Han Kim, and Professor Taek-Soo Kim from left to right
2013.11.11 View 8054 -
The World Economic Forum Invites KAIST to 2014 Davos Forum
President Steve Kang and Distinguished Professor Sang Yup Lee have been invited by the World Economic Forum (WEF) to attend its annual meeting slated for January 22-25, 2014 in Davos-Klosters, Switzerland.
The president will also join the Global University Leaders Forum (GULF) to be held during the annual meeting. The GULF consists of leading research universities throughout the world, at which President Kang will address agenda related to higher education and research.
From September 11th to 13th, KAIST was invited to the WEF’s 2013 Summer Davos Forum held in Dalian, China. The Summer Davos Forum is recognized as a barometer of the world economy, and KAIST hosted three sessions there.
In a session titled “Smart Regulations,” Professor Sang Yup Lee hosted presentations and discussions under the topic of “How regulation models can strengthen technical innovation and expansion.” President Steve Kang, Peter Sands, CEO of Standard Chartered Bank Group, Mark Weinberger, CEO of Ernest & Young, and Peter Terium, CEO of RWE, participated in the discussions.
The KAIST delegates also presented and participated in a session titled “From Trade Center to Innovative Hub” to discuss how to lead innovations in Asia, as well as “Marine Resources: Finding New Frontier” to address issues of how to develop and manage oceanic resources for potential growth.
President Kang said, “The World Economic Forum allows us to introduce the results of our innovative and creative research to global leaders and to demonstrate that our global position continues to grow.”
The WEF has been hosting Summer Davos Forum in China since 2007. About 1,500 participants from over 90 countries joined in this year’s summer forum under the theme of “Innovation: Inevitable Mainstream.” New strategies for innovations and solutions for global threats were suggested through presentations and discussions in 125 sessions.
The World Economic Forum (WEF) is an independent, international, and non-profit organization based in Geneva, Switzerland. It is committed to improving the state of the world by engaging business, political, academic, and government leaders to shape global, regional and industry agenda.
Among the meetings and forums organized by the WEF, its annual meeting held each January in Davos, a.k.a. the Davos Forum, has been the best known gathering. The Davos Forum brings together some 2,500 top business leaders, international political leaders, selected intellectuals and journalists to discuss the most pressing issues facing the world including health and environment.
2013.11.07 View 10197 -
KAIST graduate appointed as professor at Southeast University in China
Dr. Yoon-Kyu Ahn has been appointed as a professor in the civil engineering department at Southeast University in Nanjing, China.
Dr. Ahn earned his Master’s and Ph.D. in civil & environmental engineering at KAIST, under the guidance of Professor Hoon Sohn, following his undergraduate studies at Korea University.His appointment is considered quite exceptional since most of top Chinese universities are likely hiring professors from the US and EU as a general trend.Ranked third in the field of civil engineering in China, Southeast University has been among the top ten universities in the nation. The university has 27,000 students with 1,300 faculty members in 34 schools.
2013.11.06 View 6528 -
Professor Jae-Hyung Lee appointed as AIChE fellow
Professor Jae-Hyung Lee from the Department of Chemical and Bimolecular Engineering at KAIST was appointed as a fellow in the American Institute of Chemical Engineers (AIChE).
Established in 1908, AIChE is the largest association of chemical engineers worldwide, which now boasts more than 40,000 members from 90 countries.
Following Distinguished Professor Sang Yup Lee from the same department at KAIST, Professor Jae-Hyung Lee is the second Korean appointed as a fellow by the organization.
He has been acknowledged for his innovative research on the improvement of model predictive control of industrial processes.
Professor Lee is the director of the Saudi Armaco-KAIST CO2 Management Center at KAIST, a fellow of the Institute of Electrical and Electronics Engineers (IEEE) and the International Federation of Automatic Control (IFAC), and a member of the Korean Academy of Science and Technology.
He received the Young Investigator Award from the National Science Foundation (NSF) in 1994 and the Computing in Chemical Engineering Award from AIChE in 2013.
2013.11.05 View 8828