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KAIST Invites Entrepreneurs and Experts to Participate in a Social Technology Innovation Symposium
The Research Institute for Social Technology and Innovation (RISTI) at KAIST hosted the Social Technology Innovation Symposium on November 4, 2015 in KI building, to which 100 social business entrepreneurs and experts in the field were invited.
Social businesses refer to activities of companies, which strive to resolve social problems such as environmental issues, income inequality, and aging societies while seeking profit at the same time. This is different from companies taking social responsibility and non-profit organization serving the community in that they attempt to solve social problems through a sustainable business model.
Held under the theme of “technology capabilities of companies and social business strategies,” this symposium was the first to gather representatives from social venture companies, medium-sized enterprises, and major companies at one place to share their experiences in a social business and to discuss future tasks.
The symposium was divided into sessions with three different topics ranging from social business strategies using information technology, a social business and its business model, and social business strategies of major companies.
The symposium started with keynote speeches delivered by Professor HongKyu Lee, RISTI, and Professor Hong-Tak Lim, RISTI, who discussed the role of technology in a social business. It was followed by plenary sessions led by CEOs who are running social businesses such as the Sharing and Technologies Incorporated Project, Simwon Technology, Ecojun Company, Underdogs, and the Farming Fund as well as by representatives from a social responsibility section of CJ management team and the social responsibility council of SK. In the future, these talks will serve as a medium to share their experiences in social businesses and to discuss the role of technology in the business. Some talks touched upon topics such as development of platforms for social innovation, social businesses employing disabled workers, and crowd funding for farming.
The Director of RISTI, Professor HongKyu Lee said, “The symposium will be the first to have people from leading companies in social businesses in Korea in one place.” He added, “This will be a great opportunity for anyone to know what will be the future of social businesses, which were created to solve the social problems caused by capitalism.”
The symposium was sponsored by the Ministry of Trade, Industry, and Energy of Korea.
2015.10.30 View 7464 -
Establishment of System Metabolic Engineering Strategies
Although conventional petrochemical processes have generated chemicals and materials which have been useful to mankind, they have also triggered a variety of environmental problems including climate change and relied too much on nonrenewable natural resources. To ameliorate this, researchers have actively pursued the development of industrial microbial strains around the globe in order to overproduce industrially useful chemicals and materials from microbes using renewable biomass. This discipline is called metabolic engineering.
Thanks to advances in genetic engineering and our knowledge of cellular metabolism, conventional metabolic engineering efforts have succeeded to a certain extent in developing microbial strains that overproduce bioproducts at an industrial level. However, many metabolic engineering projects launched in academic labs do not reach commercial markets due to a failure to fully integrate industrial bioprocesses.
In response to this, Distinguished Professor Sang Yup Lee and Dr. Hyun Uk Kim, both from the Department of Chemical and Biomolecular Engineering at KAIST, have recently suggested ten general strategies of systems metabolic engineering to successfully develop industrial microbial strains. Systems metabolic engineering differs from conventional metabolic engineering by incorporating traditional metabolic engineering approaches along with tools of other fields, such as systems biology, synthetic biology, and molecular evolution.
The ten strategies of systems metabolic engineering have been featured in Nature Biotechnology released online in October 2015, which is entitled "Systems strategies for developing industrial microbial strains."
The strategies cover economic, state-of-the-art biological techniques and traditional bioprocess aspects. Specifically, they consist of: 1) project design including economic evaluation of a target bioproduct; 2) selection of host strains to be used for overproduction of a bioproduct; 3) metabolic pathway reconstruction for bioproducts that are not naturally produced in the selected host strains; 4) increasing tolerance of a host strain against the bioproduct; 5) removing negative regulatory circuits in the microbial host limiting overproduction of a bioproduct; 6) rerouting intracellular fluxes to optimize cofactor and precursor availability necessary for the bioproduct formation; 7) diagnosing and optimizing metabolic fluxes towards product formation; 8) diagnosis and optimization of microbial culture conditions including carbon sources; 9) system-wide gene manipulation to further increase the host strain's production performance using high-throughput genome-scale engineering and computational tools; and 10) scale-up fermentation of the developed strain and diagnosis for the reproducibility of the strain's production performance.
These ten strategies were articulated with successful examples of the production of L-arginine using Corynebacterium glutamicum, 1,4-butanediol using Escherichia coli, and L-lysine and bio-nylon using C. glutamicum.
Professor Sang Yup Lee said, "At the moment, the chance of commercializing microbial strains developed in academic labs is very low. The strategies of systems metabolic engineering outlined in this analysis can serve as guidelines when developing industrial microbial strains. We hope that these strategies contribute to improving opportunities to commercialize microbial strains developed in academic labs with drastically reduced costs and efforts, and that a large fraction of petroleum-based processes will be replaced with sustainable bioprocesses."
Lee S. Y. & Kim, H. U. Systems Strategies for Developing Industrial Microbial Strains. Nature Biotechnology (2015).
This work was supported by the Technology Development Program to Solve Climate Change on Systems Metabolic Engineering for Biorefineries (NRF-2012M1A2A2026556) and by the Intelligent Synthetic Biology Center through the Global Frontier Project (2011-0031963) from the Ministry of Science, ICT and Future Planning (MSIP), Korea, and through the National Research Foundation (NRF) of Korea. This work was also supported by the Novo Nordisk Foundation.
Picture: Concept of the Systems Metabolic Engineering Framework
(a) Three major bioprocess stages (b) Considerations in systems metabolic engineering to optimize the whole bioprocess. List of considerations for the strain development and fermentation contribute to improving microbial strain's production performance (red), whereas those for the separation and purification help in reducing overall operation costs by facilitating the downstream process (blue). Some of the considerations can be repeated in the course of systems metabolic engineering.
2015.10.19 View 9788 -
KAIST Agrees to Personnel Exchange with the Ministry of Economic Affairs of the Republic of China
A delegation from the Ministry of Economic Affairs (MOEA) of the Republic of China (ROC) visited KAIST on October 16, 2015.
President Steve Kang of KAIST and Director General Yu-Ping Lien of the Department of Investment Services, MOEA, signed a memorandum of understanding (MOU) on exchanging personnel, recruiting and attracting top talents, and sharing job information.
With the MOU, KAIST and MOEA will develop a mobility program for students in Korea and ROC to help them seek employment opportunities in both nations. Director General Lien hoped that the MOU would bring more of KAIST students in the information technology field to work in ROC.
President Kang responded,
“KAIST has fostered highly talented engineers and researchers across all fields of science and engineering. If these students can have a place in ROC to realize their potential, this certainly could benefit the two nations.”
In the picture from left to right is Director General Yu-Ping Lien of the Department of Investment Services, the Ministry of Economic Affairs of the Republic of China and President Steve Kang of KAIST.
2015.10.17 View 4888 -
Visit by Danish Folk High School: Vallekilde Højskole
A group of 60 Danish students and teachers from Vallekilde Højskole, one of 70 Folk High Schools that are spread across Denmark, visited KAIST on October 16, 2015.
The Danish delegation and KAIST’s student organization, the International Conference for the Integration of Science, Technology, and Society (ICISTS), jointly ran a conference entitled “Learning through Having Fun and Games.”
At the conference, the Headmaster of Game Academy at Vallekilde Højskole, Thomas Vigild, gave a lecture on how Vallekilde Folk High School is educating new generations with play, curiosity, and collaboration.
During the conference, KAIST and Danish students held an event called the PlayShop, which was hosted by Headmaster Vigild. At the PlayShop, some 80 students from both institutions enjoyed Danish folk games and shared cross-cultural experiences.
The Danish Folk High School, which dates back to 1844 when its first school opened in Southern Denmark, started as a civic school offering equal learning opportunities to people less fortunate to receive a regular education.
Today, the Folk High School has grown into life-long educational institutions that provide Danish citizens from high school students to seniors with alternative, complementary education that allows citizens to venture out into new fields of their interest or further hone their professional skills and knowledge.
Established in 1865, the Vallekilde Folk High School specializes in journalism, game development, event management, literature, crafts, youth leadership, music and design. Its game development classes at the Game Academy are known for helping students reach their potential through learning from fun games, creative initiatives, and collaborative projects.
The invitation of the Danish school was made possible by Director Heekyung Park of the Institute of Disaster Studies at KAIST.
Director Park said,
“In a sense, I could say that all Danish Folk High Schools are an ideal form of delivering education. They pursue ways to teach students without losing their curiosity and interest in subjects. The schools remove any type of exams from classrooms, while striving to ensure the maximum participation of students in the learning process. KAIST could emulate some of these educational practices to offer its students a classroom free of stress and full of inspirations.”
The Danish delegation toured KAIST’s Humanoid Research Center and the Urban Robotics Lab after the conference.
2015.10.16 View 5102 -
KAIST Teams Up with Korean Universities for MOOCs
KAIST, Seoul National University (SNU), and the Pohang University of Science and Technology (POSTECH) agreed to cooperate in the development of Massive Open Online Courses (MOOCs) for Korean viewers. The agreement ceremony took place at the SNU campus on October 14, 2015.
Under the agreement, professors from all three universities will jointly create and implement online courses on science and engineering by the summer of 2016. The MOOCs will largely consist of basic courses on physics, chemistry, life science, mechanical engineering, and material science. Anyone from a high school student to an adult who is interested in science can take these online courses.
Some of the participating professors will be President Doh-Yeon Kim of POSTECH, Dean Seong-Keun Kim of Natural Sciences College at SNU, Dean Kun-Woo Lee of Engineering College at SNU, Dean Jung-Hoe Kim of Life Science and Bioengineering College at KAIST, Dean Do-Kyung Kim of Academic Affairs at KAIST, Dean Kun-Hong Lee of Engineering College at POSTECH, and Dean Joon-Won Park of Science College at POSTECH.
President Steve Kang of KAIST said,
“Many of Korea’s most distinguished professors in science and engineering will participate in the MOOCs. People, particularly young students aspiring to study science and technology at universities, should definitely take advantage of this opportunity.”
In the picture from left to right is President Steve Kang of KAIST, President Nak-In Sung of Seoul National University, and President Doh-Yeon Kim of Pohang University of Science and Technology.
2015.10.14 View 6832 -
Professor Key-Sun Choi Receives the Order of Service Merit Green Stripes from the Korean Government
The award recognizes Professor Choi’s life-long research effort to make Korean language digitally available, both nationally and internationally.
Professor Key-Sun Choi of the School of Computing at KAIST received the Order of Service Merit Green Stripes from the Korean government at the 569th Korean Language Day, held annually to commemorate the invention of the Korean language, Hangeul. The ceremony took place on October 9, 2015, at the Sejong Center in Seoul.
Professor Choi has distinguished himself in the field of natural language processing (NLP), including Korean language. He developed a Korean NLP parser that enabled information processing and data analysis of Korean language, as well as a digital Korean dictionary, contributing to the advancement of Korean language-based information technology.
Professor Choi also led the way to widespread use of Korean natural language in computing by developing and commercializing open source software to process the Korean language.
He has served leading roles in many of the international academic societies and standardization organizations, among others, as the vice president of Infoterm (the International Information Center for Terminology), president of the Asia Federation of Natural Language Processing, vice chair of ISO/TC 37, a technical committee in the International Organization for Standardization (ISO), and a council member for the International Association of Machine Translation.
2015.10.08 View 7534 -
Professor Kyung-Won Chung Receives the 2015 Design Value Awards
The Design Management Institute (DMI) announced eleven winners of its 2015 Design Value Awards.
Professor Kyung-Won Chung of the Industrial Design Department at KAIST took one of the four First Place Design Value Awards. The award ceremony was held on September 28, 2015, at the Royal Sonesta Hotel in Boston.
DMI is an international organization that has actively advocated for the strategic value of design, sponsoring research, publishing academic papers, connecting members across disciplines and the globe, and sharing best design practices.
Commemorating its 40th anniversary, DMI created the inaugural Design Value Awards this year, which honors the contributions of design teams who have delivered significant value through design or design management practices.
There were four categories of the awards: first, second, and third prize, and Honorable Mention. The first place had four winners; both the second and third took two winners each. The honorable mention included three awardees.
The award noted Professor Chung's contributions to the development of design management theory and practices in Korea and his dedication to elevate KAIST’s industrial design department to one of the 30 leading design institutions in the world during his 30-year career at the university.
DMI also appointed Professor Chung a Life Fellow.
Professor Chung said,
“I am greatly honored to receive such a significant award, the equivalent of the Academy Awards in the field of design. I hope this award will encourage the further development of the Korean design industry to lead the global design community.”
He has served in various important positions in public and private organizations, including as the president of the Korea Institute of Design Promotion, Vice Mayor of Design for the City of Seoul, Advisor to the Design Division of Samsung Electronics, and a member of organizing committee of the International Council of Societies of Industrial Design.
2015.10.04 View 6011 -
Nikon Instruments Korea Donates a Fund to KAIST's Department of Biological Sciences
Representatives from Nikon Instruments Korea Co., Ltd., a producer of microscopes and measuring instruments, visited the KAIST campus on September 25, 2015, and donated USD 9,000 to the Department of Biological Sciences at KAIST.
A small ceremony to mark the donation took place at the department’s conference room.
In the picture from left to right were Professor Won-Do Heo, Department Head Byung-Ha Oh, Professor Sangyong Jon, President Sam-Sup Jang of Korea Instech, and Director Ik-Soo Yoo of Nikon Instruments Korea.
The department announced that the fund would be used to build its new research center to house the state-of-the-art research equipment and tools for the development of new medicine.
2015.10.03 View 4720 -
Professor Junehwa Song Appointed as the General Chair of the Organizing Committee of ACM SenSys
Professor Junehwa Song from the Schooling of Computing at KAIST has been appointed the general chair of the organizing committee of ACM SenSys—the American Computing Machine (ACM) Conference on Embedded Networked Sensor Systems.
ACM SenSys held its first conference in 2003 to promote research on wireless sensor networks and embedded systems. Since then, it has expanded into an influential international conference especially with the increasing importance in sensor technologies. Recently the committee has expanded its field of interest to mobile sensors, the Internet of Things, smart device system, and security.
Professor Song is considered a world-renown researcher in mobile and ubiquitous computing system. He presented numerous research papers at various conferences organized by ACM. He is also a member of the editorial committee of the Institute of Electrical and Electronics Engineers (IEEE) Transactions on Mobile Computing journal. For his achievements in the field and flair for coordinating and planning conferences, he is now the first Korean researcher to be appointed the chair of ACM SenSys.
Professor Song said that, as the chair, he would help discover new technology in and applications of networked, wireless sensors that would meet the demands of our modern society.
The 13th ACM SenSys will take place in Seoul—the first one to be held in Asia. The event will begin on November 1, 2015 and last four days. More information about this year’s event can be found at http://sensys.acm.org/2015/.
2015.10.02 View 6484 -
Professor Sang-Min Bae receives the 2015 IDEA Awards
Professor Sang-min Bae of the Industrial Design Department at KAIST garnered one silver and two bronze awards from the 2015 International Design Excellence Awards (IDEA). Along with iF Design Award and Red Dot Design Awards, the IDEA is regarded as one of the world’s most respected recognition in the field of design.
Trash to Bin (T2B), a silver winner in the category of Social Impact Design, is a trash bin made of 1.87 lb (0.85 kg) of discarded papers. Using one-hundred percent recycled paper pulp, each T2B costs under $5 for production. The bin can be fully waterproofed for at least six hours. While satisfying with the industry safety standards, this environmentally-friendly bin can be produced on a large scale using litter energy, but offering the exact same benefit of a general garbage can.
Roll-Di, one of the two bronze winners, is a direction indicator that tells which string of screen curtains should be pulled to make the curtain go up or down. As shown in the picture below, Roll-Di can be installed at the bottom of the string, and the “up and down” arrows show which side of the string needs to be pulled to achieve the desired position of the curtain. This simple, yet handy solution to the problem that people frequently make the mistake of pulling the wrong string provides users with greater convenience.
The other bronze winner is Printing Solar-cell, an organic cartridge module that prints solar-cells using a domestic, ink-jet printer. With Printing Solar-cell, users can design their own cell patterns and charge their electronics anywhere holding the printed solar-cell on a copy paper.
Professor Bae said, “I’ve always tried to design something that is useful for people in need. I consider the IDEA awards an encouragement to keep up with my work toward that goal.”
Trash to Bin
Roll-Di
Printing Solar-cell
2015.09.30 View 6841 -
KAIST and Oberthur Technologies Agree for Research and Development in Mobile Security
Professor Kwangjo Kim of the School of Computing at KAIST has signed a research and development (R&D) agreement with Marc Bertin, the Chief Technology Officer of Oberthur Technologies (OT), a French security solutions firm, on September 18, 2015 in Paris.
Under the agreement, KAIST and OT will conduct joint research on mobile security as well as implement an internship program for KAIST graduate students to work either at OT’s R&D center in Korea or in France.
OT has established a research center in Korea in July 2014, which was the fourth of its research centers in Asia.
Professor Kim said, “Our goal at KAIST is to cultivate top-level security experts in security technologies. By partnering with such a leader in security technologies as OT, we know that we will both help shape tomorrow’s security solution for the IoT (Internet of Things) space.”
In the picture, Professor Kwangjo Kim (left) shakes hands with Marc Bertin, the Chief Technology Officer of Oberthur Technologies (right), after the signing of a memorandum of understanding.
2015.09.24 View 6758 -
Discovery of Redox-Switch of KEenzyme Involved in N-Butanol Biosynthesis
Research teams at KAIST and Kyungpook National University (KNU) have succeeded in uncovering the redox-switch of thiolase, a key enzyme for n-butanol production in Clostridium acetobutylicum, one of the best known butanol-producing bacteria.
Biological n-butanol production was first reported by Louis Pasteur in 1861, and the bioprocess was industrialized usingClostridium acetobutylicum. The fermentation process by Clostridium strains has been known to be the most efficient one for n-butanol production. Due to growing world-wide issues such as energy security and climate change, the biological production of n-butanol has been receiving much renewed interest. This is because n-butanol possesses much better fuel characteristics compared to ethanol, such as higher energy content (29.2 MJ/L vs 19.6 MJ/L), less corrosiveness, less hygroscopy, and the ease with which it can be blended with gasoline and diesel.
In the paper published in Nature Communications, a broad-scope, online-only, and open access journal issued by the Nature Publishing Group (NPG), on September 22, 2015, Professor Kyung-Jin Kim at the School of Life Sciences, KNU, and Distinguished Professor Sang Yup Lee at the Department of Chemical and Biomolecular Engineering, KAIST, have proved that the redox-switch of thiolase plays a role in a regulation of metabolic flux in C. acetobutylicum by using in silico modeling and simulation tools.
The research team has redesigned thiolase with enhanced activity on the basis of the 3D structure of the wild-type enzyme. To reinforce a metabolic flux toward butanol production, the metabolic network of C. acetobutylicum strain was engineered with the redesigned enzyme. The combination of the discovery of 3D enzyme structure and systems metabolic engineering approaches resulted in increased n-butanol production in C. acetobutylicum, which allows the production of this important industrial chemical to be cost competitive.
Professors Kim and Lee said, "We have reported the 3D structure of C. acetobutylicum thiolase-a key enzyme involved in n-butanol biosynthesis, for the first time. Further study will be done to produce butanol more economically on the basis of the 3D structure of C. acetobutylicum thiolase."
This work was published online in Nature Communications on September 22, 2015.
Reference: Kim et al. "Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum," Nature Communications
This research was supported by the Technology Development Program to Solve Climate Changes from the Ministry of Education, Science and Technology (MEST), Korea, the National Research Foundation of Korea, and the Advanced Biomass Center through the Global Frontier Research Program of the MEST, Korea.
For further information, contact Dr. Sang Yup Lee, Distinguished Professor, KAIST, Daejeon, Korea (leesy@kaist.ac.kr, +82-42-350-3930); and Dr. Kyung-Jin Kim, Professor, KNU, Daegu, Korea (kkim@knu.ac.kr, +82-53-950-6088).
Figure 1: A redox-switch of thiolase involves in butanol biosynthesis in Clostridium acetobutylicum. Thiolase condenses two acetyl-CoA molecules for initiating four carbon flux towards butanol.
Figure 2: Thiolase catalyzes the condensation reaction of acetyl-CoA to acetoacetyl-CoA. Two catalytic cysteine residues at 88th and 378th are oxidized and formed an intermolecular disulfide bond in an oxidized status, which results in inactivation of the enzyme for n-butanol biosynthesis. The intermolecular disulfide bond is broken enabling the n-butanol biosynthesis, when the environment status is reduced.
2015.09.23 View 9826