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Light Driven Drug-Enzyme Reaction Catalytic Platform Developed
Low Cost Dye Used, Hope for Future Development of High Value Medicinal Products to Treat Cardiovascular Disease and Gastric Ulcers
A KAIST research team from the Departments of Materials Science and Engineering and of Chemical and Biomolecular Engineering, led respectively by Professors Chan Beum Park and Ki Jun Jeong, has developed a new reaction platform to induce drug-enzyme reaction using light.
The research results were published in the journal Angewandte Chemie, International Edition, as the back cover on 12 January 2015.
Applications of this technology may enable production of high value products such as medicine for cardiovascular disease and gastric ulcers, for example Omeprazole, using an inexpensive dye.
Cytochrome P450 is an enzyme involved in oxidative response which has an important role in drug and hormone metabolism in organisms. It is known to be responsible for metabolism of 75% of drugs in humans and is considered a fundamental factor in new drug development.
To activate cytochrome P450, the enzyme must receive an electron by reducing the enzyme. In addition, NADPH (a coenzyme) needs to be present. However, since NADPH is expensive, the use of cytochrome P450 was limited to the laboratory and has not yet been commercialized.
The research team used photosensitizer eosin Y instead of NADPH to develop “Whole Cell Photo-Biocatalysis” in bacteria E. coli. By exposing inexpensive eosin Y to light, cytochrome P450 reaction was catalyzed to produce the expensive metabolic material.
Professor Park said, “This research enabled industrial application of cytochrome P450 enzyme, which was previous limited.” He continued, “This technology will help greatly in producing high value medical products using cytochrome P450 enzyme.”
The research was funded by the National Research Foundation of Korea and KAIST's High Risk High Return Project (HRHRP).
Figure 1: Mimetic Diagram of Electron Transfer from Light to Cytochrome P450 Enzyme via Eosin Y, EY
Figure 2: The back cover of Angewandte Chemie published on 12 January 2015, showing the research results
2015.01.26 View 9603 -
KAIST Announces the Recipients of Distinguished Alumni Awards
The KAIST Alumni Association (KAA) announced four “Proud KAIST Alumni” awards recipients for the year 2014: Sung-Wook Park, the Chief Executive Officer and President of SK Hynix; Seung Ho Shin, the President of Kangwon National University; Kew-Ho Lee, the President of the Korea Research Institute of Chemical Technology; and Mun-Kee Choi, the former Minister of Science, ICT and Future Planning of the Republic of Korea. The award ceremony took place during the 2015 KAA’s New Year's ceremony on January 17, 2015 at the Palace Hotel in Seoul.
Sung-Wook Park (M.S. ’82 and Ph.D. ’88, Department of Materials Science and Engineering), the Chief Executive Officer and President of SK Hynix, has worked as an expert in the field of memory semi-conductors for the past 30 years. He developed innovative technology and improved production efficiency, enabling the Korean semi-conductor industry to become a global leader.
Seung Ho Shin (M.S. ’79 and Ph.D. ’87, Department of Physics), the President of Kangwon National University (KNU), worked in the field of optical information processing, producing excellent research achievements and teaching the next generation of scientists. As the president of KNU, he has set an exemplary leadership in higher education.
Kew-Ho Lee (M.S. ’75, Department of Chemistry), the President of the Korea Research Institute of Chemical Technology, pioneered the field of separation film production which contributed greatly to Korean technological developments. He led several domestic and international societies to facilitate dynamic exchanges between industry and academia and with the international community.
Mun-Kee Choi (M.S. ’76, Department of Industrial and Systems Engineering), the former Minister of Science, ICT and Future Planning, the Republic of Korea, is a great contributor to the information and communications technology in Korea, working as a leader in the field of broadband integrated service digital network. He is also an educator for gifted students in science and technology, and a manager of the Electronics and Telecommunications Research Institute.
The Alumni Association established the “Proud KAIST Alumni Awards” in 1992 to recognize its alumni’s outstanding contributions to Korea and KAIST.
Pictured from left to right, Sung-Wook Park (the Chief Executive Officer and President of SK Hynix), Seung Ho Shin (the President of Kangwon National University), Kew-Ho Lee (the President of the Korea Research Institute of Chemical Technology), and Mun-Kee Choi (the former Minister of Science, ICT and Future Planning)
2015.01.19 View 12750 -
Professor Eunjoon Kim Is KAIST's Person of the Year 2014
KAIST announced that it has named Chair Professor Eunjoon Kim of the Department of Biological Sciences as its “Person of the Year 2014.” The award ceremony took place at the auditorium on campus on January 5, 2014.
Established in 2001, the award has been presented to a KAIST faculty member who has made great achievements in research and education, thereby contributing to the advancement of KAIST.
Professor Kim was the first to identify the mechanism of synapse formation between neurons during his post-doctoral program at Harvard Medical School in 1995. The research was published in Nature.
In 2011, Professor Kim discovered that the lack of protein GIT1, a neuronal synapse in the brain, caused ADHD (Attention Deficit Hyperactivity Disorder). He is widely recognized for his work concerning synapse proteins and brain disease related research that set the foundation for future medical developments.
In his award speech, Professor Kim said, “Whenever a research finding concerning a new drug therapy or research is published, I receive many inquiries from the parents of children with ADHD or autism. As a scientist, I would like to focus my research ultimately to help those in pain, rather than just pursuing research excellence or reputation.”
2015.01.06 View 9765 -
The Graduate School of Green Growth at KAIST Holds a Student Conference
The Graduate School of Green Growth at KAIST hosted a student conference on December 22, 2014 at the Seoul campus of the College of Business. About 100 master’s and doctoral students joined the conference held under the theme of “Green Knowledge Hub” and presented their research papers.
At the conference, three students received awards. The author of a paper entitled “Development and Analysis of Climate Change Vulnerability Index Applicable to Developing Countries” received the grand prize. The authors of “Green IT and Its Case Study on the Reduction of Greenhouse Gas Emissions by Industry” and “Analysis of Correlation between Consumers’ Subjective Happiness and Their Green Purchasing” were selected for runner-up prizes, respectively.
Dean Jae-Kyu Lee of the Green Growth Graduate School said, “We offered the conference to our students to engage with their peers and share ideas and knowledge in their majors. I hope students become more motivated, and we will continue holding this event in the future.”
2015.01.05 View 6737 -
A Key Signal Transduction Pathway Switch in Cardiomyocyte Identified
A KAIST research team has identified the fundamental principle in deciding the fate of cardiomyocyte or heart muscle cells. They have determined that it depends on the degree of stimulus in β-adrenergic receptor signal transduction pathway in the cardiomyocyte to control cells' survival or death. The findings, the team hopes, can be used to treat various heart diseases including heart failure.
The research was led by KAIST Department of Bio and Brain Engineering Chair Professor Kwang-Hyun Cho and conducted by Dr. Sung-Young Shin (lead author) and Ph.D. candidates Ho-Sung Lee and Joon-Hyuk Kang. The research was conducted jointly with GIST (Gwangju Institute of Science and Technology) Department of Biological Sciences Professor Do-Han Kim’s team. The research was supported by the Ministry of Science, ICT and Future Planning, Republic of Korea, and the National Research Foundation of Korea. The paper was published in Nature Communications on December 17, 2014 with the title, “The switching role of β-adrenergic receptor signalling in cell survival or death decision of cardiomyocytes.”
The β-adrenergic receptor signal transduction pathway can promote cell survival (mediated by β2 receptors), but also can result in cell death by inducing toxin (mediated by β1 receptors) that leads to various heart diseases including heart failure. Past attempts to identify the fundamental principle in the fate determining process of cardiomyocyte based on β-adrenergic receptor signalling concluded without much success.
The β-adrenergic receptor is a type of protein on the cell membrane of cardiomyocyte (heart muscle cell) that when stimulated by neurohormones such as epinephrine or norepinephrine would transduce signals making the cardiomyocyte contract faster and stronger.
The research team used large-scale computer simulation analysis and systems biology to identify ERK* and ICER** signal transduction pathways mediated by a feed-forward circuit as a key molecular switch that decides between cell survival and death.
Weak β-adrenergic receptor stimulations activate ERK signal transduction pathway, increasing Bcl-2*** protein expression to promote cardiomyocyte survival. On the other hand, strong β-adrenergic receptor stimulations activate ICER signal transduction pathway, reducing Bcl-2 protein expression to promote cardiomyocyte death.
Researchers used a systems biology approach to identify the mechanism of B-blocker****, a common drug prescribed for heart failure. When cardiomyocyte is treated with β1 inhibitor, strong stimulation on β-adrenergic receptor increases Bcl-2 expression, improving the chance of cardiomyocyte survival, a cell protection effect.
Professor Kwang-Hyun Cho said, “This research used systems biology, an integrated, convergence research of IT (information technology) and BT (biotechnology), to successfully identify the mechanism in deciding the fate of cardiomyocytes based on the β-adrenergic receptor signal transduction pathway for the first time. I am hopeful that this research will enable the control of cardiomyocyte survival and death to treat various heart diseases including heart failure.”
Professor Cho’s team was the first to pioneer a new field of systems biology, especially concerning the complex signal transduction network involved in diseases. Their research is focused on modelling, analyzing simulations, and experimentally proving signal pathways. Professor Cho has published 140 articles in international journals including Cell, Science, and Nature.
* ERK (Extracellular signal-regulated kinases): Signal transduction molecule involved in cell survival
** ICER (Inducible cAMP early repressor): Signal transduction molecule involved in cell death
*** Bcl-2 (B-cell lymphoma 2): Key signal transduction molecule involved in promotion of cell survival
**** β-blocker: Drug that acts as β-adrenergic receptor inhibitor known to slow the progression of heart failure, hence used most commonly in medicine.
Picture: A schematic diagram for the β-AR signalling network
2015.01.05 View 12307 -
Professor Mikyoung Lim Receives the MediaV Young Researcher Award
Professor Mikyoung Lim of the Department of Mathematical Sciences at KAIST received the MediaV Young Researchers Award at the International Conference on Inverse Problems and Related Topics that took place at the National Taiwan University, Taiwan, on December 15-19, 2014.
The Conference established the MediaV Young Researcher Award in 2010 to recognize distinguished scholars who are age 40 or younger and have made important contributions to the field of inverse problems. This year, two recipients were chosen for the award.
Professor Lim has focused her research on the incremental reading of incomprehensible materials’ imaging and the effect of invisibility cloaking.
The other awardee was Kui Ren, a professor at the University of Texas at Austin.
2014.12.27 View 9846 -
IamCompany and KAIST's Midam Scholarship Contribute Scholarship to High School Students
IamCompany, a venture company established by a KAIST student which provides mobile users with educational applications, and Midam Scholarship, a volunteer group consisting of KAIST students that helps junior and high school students study math and science, selected a total of 118 students and presented them with scholarships.
Among the students, Ki-Bum Kim of Kyung-Hee High School in Seoul received USD 1,300, the largest sum.
In-Mo Chung, the President of IamCompany, who once worked as a member of Midam Scholarship, said, “I joined this scholarship program to support the Midam Scholarhsip which offers educational services to less privileged students. I hope many young students will benefit from this and receive an equal opportunity for better education.”
2014.12.15 View 6300 -
KAIST wins second place in unmanned boat competition
KAIST took second place in an international competition to promote technologies of the autonomous underwater vehicle (AUV).
Professor Jin-hwan Kim’s research team from KAIST’s Ocean Systems Engineering Department won the second place in Maritime RobotX Challenge which took place for the first time from October 20 - 26 in Marina Bay, Singapore.
Along with automobiles and drones, the necessity for unmanned boats has grown. To encourage and examine the development of these technologies, the U.S. Office of Naval Research decided to organize an unmanned boat competition which took place for the first time this year.
After three teams were selected from a domestic competition in each countries, a total of fifteen teams from five countries from the Pacific Rim including Korea, the United States, Australia, Japan, and Singapore competed. Teams from such universities as MIT, Tokyo University, Tokyo Institute of Technology, National University of Singapore, Nanyang Technological University, and Queensland University of Technology participated. In addition to KAIST, Seoul National University and Ulsan University participated.
Using a 4.5 meters long and 2.5 meters wide unmanned boat provided by the organizer, each team had to implement an integrated system that combined a propulsion system, hardware, and autonomous software. Each team’s vessel had to perform tasks without manual control, employing autonomous driving through recognition of the course, searching underwater for acoustic sources, automatically approaching piers, remote observation of buoy, and avoidance and detection of obstacles.
Although KAIST outpaced MIT in the semifinal which selected six out of fifteen teams, it won the second place in the final. As well as winning second prize, KAIST also won best website prize and a special prize from the competition sponsor, Northrop Grumman Corporation, an American defense technology company, totaling 16,500 U.S. dollars of prize money.
The Vice President for Planning and Budget, Professor Seungbin Park said, “It was a great opportunity to showcase the advanced unmanned robot technology of Korea.” He added that “this raised KAIST’s reputation as a global research oriented university.”
Professor Kim commented, “Along with automobiles and drones, the necessity for the development of unmanned ocean vehicles such as unmanned boats and submarines are recognized these days.” He added that “the use of unmanned boats will make the process of channel investigation, ocean exploration, surveillance over water territories safer and more effective.”
Professor Kim’s team was sponsored by the U.S. Office of Naval Research, Samsung Heavy Industries, Sonar Tech, Daeyang Electric, and Red-one Technology.
KAIST Team's Unmanned Boat
The Competition's Missions
2014.12.12 View 10367 -
Nanoparticle Cluster Manufacturing Technique Using DNA Binding Protein Developed
Professor Hak-Sung Kim of the Department of Biological Sciences at KAIST and Yiseul Ryu, a doctoral candidate, used the Zinc Finger protein that specifically binds to target DNA sequence to develop a new manufacturing technique for size-controllable magnetic Nanoparticle Clusters (NPCs). Their research results were published in Angewandte Chemie International Edition online on 25 November 2014.
NPCs are structures consisting of magnetic nanoparticles, gold nanoparticles, and quantum dots, each of which are smaller than 100 nm (10-9m). NPCs have a distinctive property of collectivity not seen in single nanoparticles.
Specifically NPCS differ in physical and optical properties such as Plasmon coupling absorbance, energy transfers between particles, electron transfers, and conductivity. Therefore, NPCs can be employed in biological and medical research as well as the development of nanoelectric and nanoplasmon devices.
To make use of these novel properties, the size and the composition of the cluster must be exquisitely controlled. However, previous techniques relied on chemical binding which required complex steps, making it difficult to control the size and composition of NPCs.
Professor Kim’s team used Zinc Finger, a DNA binding protein, to develop a NPCs manufacturing technique to create clusters of the desired size easily. The Zinc Finger protein contains a zinc ion and specifically recognizes DNA sequence upon binding, which allows the exquisite control of the size and the cluster composition. The technique is also bio-friendly.
Professor Kim’s team created linear structure of different sizes of NPCs using Zinc Finger proteins and three DNA sequences of different lengths. The NPCs they produced confirmed their ability to control the size and structure of the cluster by using different DNA lengths.
The NPCs showed tripled T2 relaxation rates compared to the existing MRI contrast media (Feridex) and effectively transported to targeted cells. The research findings show the potential use of NPCs in biological and medical fields such as MRI contrast media, fluorescence imaging, and drug transport.
The research used the specific binding property of protein and DNA to develop a new method to create an inorganic nanoparticle’s supramolecular assembly. The technique can be used and applied extensively in other nanoparticles for future research in diagnosis, imaging, and drug and gene delivery.
Figure 1. A Mimetic Diagram of NPCs Manufacturing Technique Using DNA Binding Protein Zinc Finger
Figure 2. Transmission Electron Microscopy Images showing different sizes of NPCs depending on the length of the DNA
2014.12.04 View 11947 -
Elsevier Selects a KAIST Graduate's Paper as the Top Cited Papers in 2011-2012
Dr. Myung-Won Seo, a graduate from the Department of Chemical and Bimolecular Engineering at KAIST, published a paper in January 2011 in Chemical Engineering Journal, which was entitled “Solid Circulation and Loop-seal Characteristics of a Dual Circulating Fluidized Bed: Experiments and CFD Simulation.” His paper was selected by Elsevier as the Top Cited Papers of 2011-2012. The Chemical Engineering Journal is a renowned peer-reviewed journal issued by Elsevier.
Dr. Seo published another paper, “CFD Simulation with Experiments in a Dual Circulating Fluidized Bed Gasifier,” in January 2012 in Computers & Chemical Engineering, which was also selected as the Most Downloaded Papers in 2012-2013.
Dr. Seo graduated with a doctoral degree from KAIST in 2011. He is currently working at the Clean Fuel Laboratory, the Korea Institute of Energy Research, Daejeon, as a researcher. His research areas are coal gasification, upgrading, and liquefaction, as well as energy and chemical production from low-grade fuels such as biomass and wastes.
2014.11.24 View 8770 -
The 2014 Wearable Computer Competition Takes Place at KAIST
“This is a smart wig for patients who are reluctant to go outdoors because their hair is falling out from cancer treatment.”
A graduate student from Sungkyunkwan University, Jee-Hoon Lee enthusiastically explains his project at the KAIST KI Building where the 2014 Wearable Computer Competition was held. He said, “The sensor embedded inside the wig monitors the heart rate and the body temperature, and during an emergency, the device warns the patient about the situation. The product emphasizes two aspects; it notifies the patient in emergency situations, and it encourages patients to perform outdoor activities by enhancing their looks.”
The the tenth anniversary meeting of the 2014 Wearable Computer Competition took place at the KAIST campus on November 13-14, 2014.
A wearable computer is a mobile device designed to be put on the body or clothes so that a user can comfortably use it while walking. Recently, these devices that are able to support versatile internet-based services through smartphones are receiving a great deal of attention.
Wearable devices have been employed in two categorizes: health checks and information-entertainment. In this year’s competition, six healthcare products and nine information-entertainment products were exhibited.
Among these products, participants favored a smart helmet for motorcycle drivers. The driver can see through a rear camera with a navigation screen of the smartphone and text messages through the screen installed in the front glass of the helmet. Another product included a uniform that can control presentation slides by means of motion detection and voice recognition technology. Yet another popular device offered an insole to guide travelers to their destination with the help of motion sensors.
The chairman of the competition, Professor Hoi-Jun Yoo from the Department of Electrical Engineering at KAIST said, “Wearable devices such as smart watches, glasses, and clothes are gaining interest these days. Through this event, people will have a chance to look at the creativity of our students through the display of their wearable devices. In turn, these devices will advance computer technology.”
The third annual wearable computer workshop on convergence technology of wearable computers followed the competition. In the workshop, experts from leading information technology companies such as Samsung Electronics, LG Electronics, and KT Corporation addressed the convergence technology of wearable computers and trends in the field.
2014.11.19 View 9507 -
3D Printer Developed by KAIST Undergraduate Students
More than 100 Pre-orders Prior to Product Launch Made
KAIST undergraduate students received more than 100 pre-orders before the launch for 3D printers they developed and became a hot topic of interest.
KAIST Research Institute for Social Technology and Innovations (Head Hong-Kyu Lee) had a launch party at Daejeon Riviera Hotel on 17 November 2014 for “Commercial Delta 3D Printer” developed by KAIST undergraduate students inviting around 50 businesses, buyers and representatives of 3D Printing Industry Association.
“3D Printer” uses blueprints of products such as toys, mug cups and chairs to make 3D objects and is thought to be revolutionary technology in manufacturing industry. The interest has grown as recent printers could print even fruits and cosmetics.
The printing structure of 3D printer can be divided roughly into horizontal Mendel method and Delta method. KAIST students focused on the Delta method to give a differentiated product from 90% of commercial products that use Mendel method.
First, the students focused on lowering the cost of unit price by using self-developed components. The carriage (transport machine) of the product is replaced by self-developed components instead of bearing to reduce the noise and the linking method was changed to beads from loop guide to increase the completeness of the printed product. Also, an auto-levelling is loaded to ensure the nozzle and the bed is parallel and hence increasing convenience for the users. Further, the printer, designed by a product designer in Germany, is linked to a smartphone application for blueprints.
A student in the development team, Seokhyeon Seo (Department of Computer Science, 3rd Year Undergraduate) said, “The biggest merits of the product are lowering the price to a 1/3 by using self-developed components and reducing the noise.” He continued, “By using a smartphone application, anyone can easily design the product. So it is applicable to use for education or at home”
In the exhibit, “3D Printing Korea 2014,” in Coex, Seoul the printer had a preview demonstration, and received more than 100 pre-orders from educational and business training institutions. Further, buyers from Canada and the US requested opening agencies in their countries.
KAIST Research Institute for Social Technology and Innovations Head Hong-Kyu Lee said, “3D printing is an innovative technology that could bring the 3rd industrial revolution.” He continued, “It is still early days but the demand will increase exponentially.”
This project was a research project of KAIST Research Institute for Social Technology and Innovations led by a development team consisting of 4 undergraduate students of KAIST, one student from University of Oxford and one German product designer.
Students in the picture below are Won-Hoi Kim (Department of Mechanical Engineering), Sung-Hyun Cho (Department of Mechanical Engineering), and Suk-Hyun Seo (Department of Computer Science) from left to right.
2014.11.19 View 10117