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A Study Finds Neuropeptide Somatostatin Enhances Visual Processing
Researchers have confirmed that neuropeptide somatostatin can improve cognitive function in the brain. A research group of Professor Seung-Hee Lee from the Department of Biological Sciences at KAIST found that the application of neuropeptide somatostatin improves visual processing and cognitive behaviors by reducing excitatory inputs to parvalbumin-positive interneurons in the cortex. This study, reported at Science Advances on April 22nd (EST), sheds a new light on the therapeutics of neurodegenerative diseases. According to a recent study in Korea, one in ten seniors over 65 is experiencing dementia-related symptoms in their daily lives such like memory loss, cognitive decline, and motion function disorders. Professor Lee believes that somatostatin treatment can be directly applied to the recovery of cognitive functions in Alzheimer’s disease patients. Professor Lee started this study noting the fact that the level of somatostatin expression was dramatically decreased in the cerebral cortex and cerebrospinal fluid of Alzheimer’s disease patients Somatostatin-expressing neurons in the cortex are known to exert the dendritic inhibition of pyramidal neurons via GABAergic transmission. Previous studies focused on their inhibitory effects on cortical circuits, but somatostatin-expressing neurons can co-release somatostatin upon activation. Despite the abundant expression of somatostatin and its receptors in the cerebral cortex, it was not known if somatostatin could modulate cognitive processing in the cortex. The research team demonstrated that the somatostatin treatment into the cerebral cortex could enhance visual processing and cognitive behaviors in mice. The research team combined behaviors, in vivo and in vitro electrophysiology, and electron microscopy techniques to reveal how the activation of somatostatin receptors in vivo enhanced the ability of visual recognition in animals. Interestingly, somatostatin release can reduce excitatory synaptic transmission to another subtype of GABAergic interneurons, parvalbumin (PV)-expressing neurons. As somatostatin is a stable and safe neuropeptide expressed naturally in the mammalian brain, it was safe to be injected into the cortex and cerebrospinal fluid, showing a potential application to drug development for curing cognitive disorders in humans. Professor Lee said, “Our research confirmed the key role of the neuropeptide SST in modulating cortical function and enhancing cognitive ability in the mammalian brain. I hope new drugs can be developed based on the function of somatostatin to treat cognitive disabilities in many patients suffering from neurological disorders.” This study was supported by the National Research Foundation of Korea. Publication: Song, Y. H et al. (2020) ‘Somatostatin enhances visual processing and perception by suppressing excitatory inputs to parvalbumin-positive interneurons in V1’, Science Advances, 6(17). Available online at https://doi.org/10.1126/sciadv.aaz0517 Profile: Seung-Hee Lee Associate Professor shlee1@kaist.ac.kr https://sites.google.com/site/leelab2013/ Sensory Processing Lab (SPL) Department of Biological Sciences (BIO) Korea Advanced Institute of Science and Technology (KAIST) Profile: You-Hyang Song Researcher (Ph.D.) dbgidtm17@kaist.ac.kr SPL, KAIST BIO Profile: Yang-Sun Hwang Researcher (M.S.) hys940129@kaist.ac.kr SPL, KAIST BIO (END)
2020.04.23
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Former Minister of Science and Technology Woo Sik Kim Elected as New Chairman of Board of Trustees
Dr. Woo Sik Kim, former Minister of Science and Technology and Deputy Prime Minister, was elected as the new chairman of the KAIST Board of Trustees on March 26. Dr. Kim will succeed Chairman Jang-Mu Lee, whose three-year term expired last month. Dr. Kim is a chemical engineering professor who spent most of his academic career at Yonsei University from 1968. In 2000, he held the office of president of Yonsei University for four years before moving to the Presidential Office of President Roh Moo-Hyun as his chief of staff in 2004. After serving in the Blue House for two years, he served as the Minister of Science and Technology from 2006 to 2008. An emeritus fellow of the National Academy of Engineering of Korea (NAEK), Chairman Kim also taught at KAIST as an invited distinguished professor from 2008 to 2010. He is currently the chairman of the Creativity Engineering Institute (CEI). (END)
2020.04.06
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Cyber MOU Signing with Zhejiang University
KAIST signed an MOU with Zhejiang University (ZJU) in China on March 25. This MOU signing ceremony took place via video conference due to the outbreak of COVID-19. The collaboration with ZJU had already started with the signing of an MOU for cooperation in technology commercialization last December. Possible cooperation initiatives included facilitating joint start-up businesses, patent portfolios, and technology marketing. With this general agreement signing, it is expected that the two institutes will expand mutual exchanges and collaborations at the institutional level for education and research. President Sung-Chul Shin said, “We will work together to devise measures for the systematic advancement of cooperation in various directions, including education, research, and the commercialization of technologies.” ZJU, a member of the C9 League known as China’s Ivy League, was established in 1897 and is located in the city of Hangzhou. Its population across 37 colleges and schools comprises 54,641 students and 3,741 faculty members. The university was ranked 6th in Asia and 54th in the world in the 2020 QS Rankings. (END)
2020.03.30
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A Single Biological Factor Predicts Distinct Cortical Organizations across Mammalian Species
-A KAIST team’s mathematical sampling model shows that retino-cortical mapping is a prime determinant in the topography of cortical organization.- Researchers have explained how visual cortexes develop uniquely across the brains of different mammalian species. A KAIST research team led by Professor Se-Bum Paik from the Department of Bio and Brain Engineering has identified a single biological factor, the retino-cortical mapping ratio, that predicts distinct cortical organizations across mammalian species. This new finding has resolved a long-standing puzzle in understanding visual neuroscience regarding the origin of functional architectures in the visual cortex. The study published in Cell Reports on March 10 demonstrates that the evolutionary variation of biological parameters may induce the development of distinct functional circuits in the visual cortex, even without species-specific developmental mechanisms. In the primary visual cortex (V1) of mammals, neural tuning to visual stimulus orientation is organized into one of two distinct topographic patterns across species. While primates have columnar orientation maps, a salt-and-pepper type organization is observed in rodents. For decades, this sharp contrast between cortical organizations has spawned fundamental questions about the origin of functional architectures in the V1. However, it remained unknown whether these patterns reflect disparate developmental mechanisms across mammalian taxa, or simply originate from variations in biological parameters under a universal development process. To identify a determinant predicting distinct cortical organizations, Professor Paik and his researchers Jaeson Jang and Min Song examined the exact condition that generates columnar and salt-and-pepper organizations, respectively. Next, they applied a mathematical model to investigate how the topographic information of the underlying retinal mosaics pattern could be differently mapped onto a cortical space, depending on the mapping condition. The research team proved that the retino-cortical feedforwarding mapping ratio appeared to be correlated to the cortical organization of each species. In the model simulations, the team found that distinct cortical circuitries can arise from different V1 areas and retinal ganglion cell (RGC) mosaic sizes. The team’s mathematical sampling model shows that retino-cortical mapping is a prime determinant in the topography of cortical organization, and this prediction was confirmed by neural parameter analysis of the data from eight phylogenetically distinct mammalian species. Furthermore, the researchers proved that the Nyquist sampling theorem explains this parametric division of cortical organization with high accuracy. They showed that a mathematical model predicts that the organization of cortical orientation tuning makes a sharp transition around the Nyquist sampling frequency, explaining why cortical organizations can be observed in either columnar or salt-and-pepper organizations, but not in intermediates between these two stages. Professor Paik said, “Our findings make a significant impact for understanding the origin of functional architectures in the visual cortex of the brain, and will provide a broad conceptual advancement as well as advanced insights into the mechanism underlying neural development in evolutionarily divergent species.” He continued, “We believe that our findings will be of great interest to scientists working in a wide range of fields such as neuroscience, vision science, and developmental biology.” This work was supported by the National Research Foundation of Korea (NRF). Image credit: Professor Se-Bum Paik, KAIST Image usage restrictions: News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only. Publication: Jaeson Jang, Min Song, and Se-Bum Paik. (2020). Retino-cortical mapping ratio predicts columnar and salt-and-pepper organization in mammalian visual cortex. Cell Reports. Volume 30. Issue 10. pp. 3270-3279. Available online at https://doi.org/10.1016/j.celrep.2020.02.038 Profile: Se-Bum Paik Assistant Professor sbpaik@kaist.ac.kr http://vs.kaist.ac.kr/ VSNN Laboratory Department of Bio and Brain Engineering Program of Brain and Cognitive Engineering http://kaist.ac.kr Korea Advanced Institute of Science and Technology (KAIST) Daejeon, Republic of Korea Profile: Jaeson Jang Ph.D. Candidate jaesonjang@kaist.ac.kr Department of Bio and Brain Engineering, KAIST Profile: Min Song Ph.D. Candidate night@kaist.ac.kr Program of Brain and Cognitive Engineering, KAIST (END)
2020.03.11
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New Catalyst Recycles Greenhouse Gases into Fuel and Hydrogen Gas
< Professor Cafer T. Yavuz (left), PhD Candidate Youngdong Song (center), and Researcher Sreerangappa Ramesh (right) > Scientists have taken a major step toward a circular carbon economy by developing a long-lasting, economical catalyst that recycles greenhouse gases into ingredients that can be used in fuel, hydrogen gas, and other chemicals. The results could be revolutionary in the effort to reverse global warming, according to the researchers. The study was published on February 14 in Science. “We set out to develop an effective catalyst that can convert large amounts of the greenhouse gases carbon dioxide and methane without failure,” said Cafer T. Yavuz, paper author and associate professor of chemical and biomolecular engineering and of chemistry at KAIST. The catalyst, made from inexpensive and abundant nickel, magnesium, and molybdenum, initiates and speeds up the rate of reaction that converts carbon dioxide and methane into hydrogen gas. It can work efficiently for more than a month. This conversion is called ‘dry reforming’, where harmful gases, such as carbon dioxide, are processed to produce more useful chemicals that could be refined for use in fuel, plastics, or even pharmaceuticals. It is an effective process, but it previously required rare and expensive metals such as platinum and rhodium to induce a brief and inefficient chemical reaction. Other researchers had previously proposed nickel as a more economical solution, but carbon byproducts would build up and the surface nanoparticles would bind together on the cheaper metal, fundamentally changing the composition and geometry of the catalyst and rendering it useless. “The difficulty arises from the lack of control on scores of active sites over the bulky catalysts surfaces because any refinement procedures attempted also change the nature of the catalyst itself,” Yavuz said. The researchers produced nickel-molybdenum nanoparticles under a reductive environment in the presence of a single crystalline magnesium oxide. As the ingredients were heated under reactive gas, the nanoparticles moved on the pristine crystal surface seeking anchoring points. The resulting activated catalyst sealed its own high-energy active sites and permanently fixed the location of the nanoparticles — meaning that the nickel-based catalyst will not have a carbon build up, nor will the surface particles bind to one another. “It took us almost a year to understand the underlying mechanism,” said first author Youngdong Song, a graduate student in the Department of Chemical and Biomolecular Engineering at KAIST. “Once we studied all the chemical events in detail, we were shocked.” The researchers dubbed the catalyst Nanocatalysts on Single Crystal Edges (NOSCE). The magnesium-oxide nanopowder comes from a finely structured form of magnesium oxide, where the molecules bind continuously to the edge. There are no breaks or defects in the surface, allowing for uniform and predictable reactions. “Our study solves a number of challenges the catalyst community faces,” Yavuz said. “We believe the NOSCE mechanism will improve other inefficient catalytic reactions and provide even further savings of greenhouse gas emissions.” This work was supported, in part, by the Saudi-Aramco-KAIST CO2 Management Center and the National Research Foundation of Korea. Other contributors include Ercan Ozdemir, Sreerangappa Ramesh, Aldiar Adishev, and Saravanan Subramanian, all of whom are affiliated with the Graduate School of Energy, Environment, Water and Sustainability at KAIST; Aadesh Harale, Mohammed Albuali, Bandar Abdullah Fadhel, and Aqil Jamal, all of whom are with the Research and Development Center in Saudi Arabia; and Dohyun Moon and Sun Hee Choi, both of whom are with the Pohang Accelerator Laboratory in Korea. Ozdemir is also affiliated with the Institute of Nanotechnology at the Gebze Technical University in Turkey; Fadhel and Jamal are also affiliated with the Saudi-Armco-KAIST CO2 Management Center in Korea. <Newly developed catalyst that recycles greenhouse gases into ingredients that can be used in fuel, hydrogen gas and other chemicals.> Publication: Song et al. (2020) Dry reforming of methane by stable Ni–Mo nanocatalysts on single-crystalline MgO. Science, Vol. 367, Issue 6479, pp. 777-781. Available online at http://dx.doi.org/10.1126/science.aav2412 Profile: Prof. Cafer T. Yavuz, MA, PhD yavuz@kaist.ac.kr http://yavuz.kaist.ac.kr/ Associate Professor Oxide and Organic Nanomaterials for the Environment (ONE) Laboratory Graduate School of Energy, Environment, Water and Sustainability (EEWS) Korea Advanced Institute of Science and Technology (KAIST) http://kaist.ac.kr Daejeon, Republic of Korea Profile: Youngdong Song ydsong88@kaist.ac.kr Ph.D. Candidate Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology (KAIST) http://kaist.ac.kr Daejeon, Republic of Korea (END)
2020.02.17
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Distinguished Alumni Awardees 2019
The KAIST Alumni Association (KAA) announced four recipients of the Distinguished Alumni Awards for the year 2019. The awards ceremony took place during the New Year Alumni Reception on January 18, 2020 in Seoul. The Distinguished Alumni Awards recognize graduates who have achieved outstanding accomplishments in their professional and personal lives, and who have been an inspiration to fellow alumni and students in Korea and around the globe. The four distinguished alumni of the year 2019 are listed below. Myung Joon Kim (School of Computing, M.S., Class of ’78), the President of the Electronics and Telecommunications Research Institute (ETRI), is a renowned expert in software engineering who has served as the president of the Administration Division and ICT Creative Research Laboratory of ETRI. His research and leadership have contributed to fortifying the nation’s IT and electronic industry competitiveness. Dong Ryeol Shin (School of Electrical Engineering, M.S., Class of ’80), the President of Sungkyunkwan University, is a well-versed expert experienced in both academia and industry. He suggested many creative interdisciplinary educational policies and innovative education programs to lead the way in the Fourth Industrial Revolution, and fostered talents who will go on to be the foundation of national development. Dong-Myun Lee (School of Electrical Engineering, M.S., Class of ’85, Ph.D., Class of ‘87), the CTO and the head of the Institute of Convergence Technology in KT Corporation, is a creative and practical research innovator. He raised the nation’s competitiveness by leading the development of the high-speed communication network industry and the global expansion of next-generation technology business. Chang Han Kim (School of Computing, B.S., Class of ’92, M.S., Class of ’97, Ph.D., Class of ’98), the CEO of PUBG Corporation, has contributed greatly to the development of the IT contents industry. He developed PlayerUnknown’s Battlegrounds, a game that has become a global sensation. Since the establishment of the award in 1992, a total of 103 alumni at home and abroad have been honored as recipients, and brought distinction to the university. These recipients are playing major roles in society, and some of the notable awardees include: KAIST President Sung-Chul Shin (2010), Samsung Electronics Vice Chairman Ki-Nam Kim (2012), Nexon Chairman Jung-Ju Kim (2007), and the former Science and Technology Advisor to the President Kong-Joo Lee (2005). The President of KAA and the CEO of Inbody Co Ltd., Ki-Chul Cha, said, “The Distinguished Alumni Awards are honor given to the alumni who contributed to the development of the nation and society, and raised the name of their alma mater.” He added, “We can tell the proud position of KAIST in the global arena just by looking at the accomplishments of the previous awardees.” (END)
2020.01.20
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KAIST GSAI and SNUBH Join Hands for AI in Healthcare
< Dean Song Chong (left) and Director Chang Wan Oh (right) at the KAIST GSAI - SNUBH MOU Signing Ceremony > The Graduate School of AI (GSAI) at KAIST and the Seoul National University Bundang Hospital (SNUBH) signed a memorandum of understanding (MOU) to cooperate in AI education and research in the field of healthcare last month. The two institutions have agreed to collaborate on research and technology development through the implementation of academic and personnel exchange programs. The GSAI, opened in August 2019 as Korea’s first AI graduate school, has been in the forefront of nurturing top-tier AI specialists in the era of Fourth Industrial Revolution. The school employs a two-track strategy that not only provides students with core AI-related courses on machine learning, data mining, computer vision, and natural language processing, but also a multidisciplinary curriculum incorporating the five key fields of healthcare, autonomous vehicles, manufacturing, security, and emerging technologies. Its faculty members are "the cream of the crop” in their early 40s, achieving world-class performance in their respective fields. SNUBH opened the Healthcare Innovation Park in 2016, the first hospital-led convergence research complex among Korean medical institutions. It is leading future medical research in five specialized areas: medical devices, healthcare ICT, human genetics, nano-machines, and regenerative medicine. The Dean of the GSAI, Song Chong, said, “We have set the stage for a cooperative platform for continuous and efficient joint education and research by the two institutions.” He expressed his excitement, saying, “Through this platform and our expertise in AI engineering and medicine, we will lead future AI-based medical technology.” The Director of the SNUBH Research Division, Chang Wan Oh, stressed that “the mutual cooperation between the two institutions will become a crucial turning point in AI education and research, which is at the core of future healthcare.” He added, “Through a high level of cooperation, we will have the ability to bring about global competitiveness and innovation.” (END)
2019.12.27
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Team Geumo Wins Consecutive Victories in K-Cyber Security Challenge
< Professor Sang Kil Cha > < Masters Candidate Kangsu Kim and Researcher Corentin Soulet > Team Geumo, led by Professor Sang Kil Cha from the Graduate School of Information Security, won the K-Cyber Security Challenge in the AI-based automatic vulnerability detection division for two consecutive years in 2018 and 2019. The K-Cyber Security Challenge is an inter-machine hacking competition. Participants develop and operate AI-based systems that are capable of independently identifying software vulnerabilities and gaining operating rights through hacking. The K-Cyber Security Challenge, inspired by the US Cyber Grand Challenge launched by the Defense Advanced Research Projects Agency (DARPA), is hosted by the Ministry of Science and ICT and organized by the Korea Internet and Security Agency. Researcher Corentin Soulet of the School of Computing and master’s student Kangsu Kim of the Graduate School of Information Security teamed up for the competition. Professor Cha, who has led the research on software and systems security since his days at Carnegie Mellon University, succeeded in establishing a world-class system using domestic technology. In a recent collaboration with the Cyber Security Research Center, Professor Cha achieved a ten-fold increase in the speed of binary analysis engines, a key component of AI-based hacking systems. For this accomplishment, he received the Best Paper Award at the 2019 Network and Distributed System Security Workshop on Binary Analysis Research (NDSS BAR). Kangsu Kim said, "It is a great honor to win the competition two years in a row. I will continue to work hard and apply my knowledge to serve society.” (END)
2019.12.20
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Korea Policy Center for the Fourth Industrial Revolution Opens
The World Economic Forum’s Center for the Fourth Industrial Revolution opened its Korean affiliate center at KAIST on December 10. The Korea Policy Center for the 4th Industrial Revolution (KPC4IR) will develop policy norms and frameworks for accelerating the benefits of emerging technologies. Many dignitaries including KAIST President Sung-Chul Shin, National Assemblyman Sang-Min Lee, Daejeon City Mayor Her Tae-Jeong, and Managing Director of the WEF Center for the Fourth Industrial Revolution Murat Sonmez attended the opening ceremony. The center will play a vital role in helping to shape the development of national Fourth Industrial Revolution strategies and public-private initiatives. The Center will actively engage with the government on policy design and piloting activities. The Center is the result of KAIST’s close partnership with the WEF and its Center for the Fourth Industrial Revolution in San Francisco. KAIST signed an MOU with the WEF in 2017 for this collaboration. Dr. Klaus Schwab expressed his high hopes many times regarding Korea’s potential in responding to the Fourth Industrial Revolution. In addition, he said that KAIST and the City of Daejeon would play a significant role in helping the Fourth Industrial Revolution move forward. During a meeting with President Moon Jae-In last June, Dr. Schwab expressed his strong desire to collaborate with Korea, and the Korean government designated KAIST as an affiliate center of the WEF. The KPC4IR had already begun conducting policy research in the areas of block chain and precision medicine even before making a partnership with the WEF. The director of the Center, Distinguished Professor Sang Yup Lee, said, “We have focused on the development of technology but rarely talk about governance. Technology should come with policy. We will conduct policy development on how to ensure inclusive growth capitalizing on emerging technologies. We will also make policy guidelines for technological applications after considering all the ethical perspectives. President Shin also said in his opening remarks, “Korea has been a fast follower over the past decades in making economic development and innovations. I believe that the Fourth Industrial Revolution gives us the best opportunity to play the role of ‘first mover.’ I look forward to the KPC4IR serving as a ‘Think and Do’ tank, not limiting itself to the role of ‘think tank.’ We will continue to work closely with the WEF in the fields of AI, blockchain, and precision medicine.
2019.12.10
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New Members of KAST 2020
< Professor Zong-Tae Bae (Left) and Professor Sang Ouk Kim (Right) > Professor Zong-Tae Bae from the School of Management Engineering and Professor Sang Ouk Kim from the Department of Materials Science and Engineering became new fellows of the Korean Academy of Science and Technology (KAST) along with 22 other scientists in Korea. On November 22, KAST announced 24 new members for the year 2020. This includes seven scientists from the field of natural sciences, six from engineering, four from medical sciences, another four from policy research, and three from agriculture and fishery. The new fellows will begin their term from January next year, and their fellowships wll be conferred during the KAST’s New Year Reception to be held on January 14 in Seoul. (END)
2019.12.09
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Tungsten Suboxide Improves the Efficiency of Platinum in Hydrogen Production
< PhD Candidate Jinkyu Park and Professor Jinwoo Lee > Researchers presented a new strategy for enhancing catalytic activity using tungsten suboxide as a single-atom catalyst (SAC). This strategy, which significantly improves hydrogen evolution reaction (HER) in metal platinum (pt) by 16.3 times, sheds light on the development of new electrochemical catalyst technologies. Hydrogen has been touted as a promising alternative to fossil fuels. However, most of the conventional industrial hydrogen production methods come with environmental issues, releasing significant amounts of carbon dioxide and greenhouse gases. Electrochemical water splitting is considered a potential approach for clean hydrogen production. Pt is one of the most commonly used catalysts to improve HER performance in electrochemical water splitting, but the high cost and scarcity of Pt remain key obstacles to mass commercial applications. SACs, where all metal species are individually dispersed on a desired support material, have been identified as one way to reduce the amount of Pt usage, as they offer the maximum number of surface exposed Pt atoms. Inspired by earlier studies, which mainly focused on SACs supported by carbon-based materials, a KAIST research team led by Professor Jinwoo Lee from the Department of Chemical and Biomolecular Engineering investigated the influence of support materials on the performance of SACs. Professor Lee and his researchers suggested mesoporous tungsten suboxide as a new support material for atomically dispersed Pt, as this was expected to provide high electronic conductivity and have a synergetic effect with Pt. They compared the performance of single-atom Pt supported by carbon and tungsten suboxide respectively. The results revealed that the support effect occurred with tungsten suboxide, in which the mass activity of a single-atom Pt supported by tungsten suboxide was 2.1 times greater than that of single-atom Pt supported by carbon, and 16.3 times higher than that of Pt nanoparticles supported by carbon. The team indicated a change in the electronic structure of Pt via charge transfer from tungsten suboxide to Pt. This phenomenon was reported as a result of strong metal-support interaction between Pt and tungsten suboxide. HER performance can be improved not only by changing the electronic structure of the supported metal, but also by inducing another support effect, the spillover effect, the research group reported. Hydrogen spillover is a phenomenon where adsorbed hydrogen migrates from one surface to another, and it occurs more easily as the Pt size becomes smaller. The researchers compared the performance of single-atom Pt and Pt nanoparticles supported by tungsten suboxide. The single-atom Pt supported by tungsten suboxide exhibited a higher degree of hydrogen spillover phenomenon, which enhanced the Pt mass activity for hydrogen evolution up to 10.7 times compared to Pt nanoparticles supported by tungsten suboxide. Professor Lee said, “Choosing the right support material is important for improving electrocatalysis in hydrogen production. The tungsten suboxide catalyst we used to support Pt in our study implies that interactions between the well-matched metal and support can drastically enhance the efficiency of the process.” This research was supported by the Ministry of Science and ICT and introduced in the International Edition of the German journal Angewandte Chemie. Figure. Schematic representation of hydrogen evolution reaction (HER) of pseudo single-atom Pt supported by tungsten suboxide -Publication Jinkyu Park, Dr. Seonggyu Lee, Hee-Eun Kim, Ara Cho, Seongbeen Kim, Dr. Youngjin Ye, Prof. Jeong Woo Han, Prof. Hyunjoo Lee, Dr. Jong Hyun Jang, and Prof. Jinwoo Lee. 2019. Investigation of the Support Effect in Atomically Dispersed Pt on WO3−x for Utilization of Pt in the Hydrogen Evolution Reaction. International Edition of Angewandte Chemie. Volume No. 58. Issue No. 45. 6 pages. https://doi.org/10.1002/anie.201908122 -ProfileProfessor Jinwoo LeeConvergence of Energy and Nano Science Laboratoryhttp://cens.kaist.ac.kr Department of Chemical and Biomolecular EngineeringKAIST
2019.10.28
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A Single, Master Switch for Sugar Levels?
When a fly eats sugar, a single brain cell sends simultaneous messages to stimulate one hormone and inhibit another to control glucose levels in the body. Further research into this control system with remarkable precision could shed light on the neural mechanisms of diabetes and obesity in humans . A single neuron appears to monitor and control sugar levels in the fly body, according to research published this week in Nature. This new insight into the mechanisms in the fly brain that maintain a balance of two key hormones controlling glucose levels, insulin and glucagon, can provide a framework for understanding diabetes and obesity in humans. Neurons that sense and respond to glucose were identified more than 50 years ago, but what they do in our body has remained unclear. Researchers at the Korea Advanced Institute of Science and Technology (KAIST) and New York University School of Medicine have now found a single “glucose-sensing neuron” that appears to be the master controller in Drosophila, the vinegar fly, for maintaining an ideal glucose balance, called homeostasis. Professor Greg Seong-Bae Suh, Dr. Yangkyun Oh and colleagues identified a key neuron that is excited by glucose, which they called CN neuron. This CN neuron has a unique shape – it has an axon (which is used to transmit information to downstream cells) that is bifurcated. One branch projects to insulin-producing cells, and sends a signal triggering the secretion of the insulin equivalent in flies. The other branch projects to glucagon-producing cells and sends a signal inhibiting the secretion of the glucagon equivalent. When flies consume food, the levels of glucose in their body increase; this excites the CN neuron, which fires the simultaneous signals to stimulate insulin and inhibit glucagon secretion, thereby maintaining the appropriate balance between the hormones and sugar in the blood. The researchers were able to see this happening in the brain in real time by using a combination of cutting-edge fluorescent calcium imaging technology, as well as measuring hormone and sugar levels and applying highly sophisticated molecular genetic techniques. When flies were not fed, however, the researchers observed a reduction in the activity of CN neuron, a reduction in insulin secretion and an increase in glucagon secretion. These findings indicate that these key hormones are under the direct control of the glucose-sensing neuron. Furthermore, when they silenced the CN neuron rendering dysfunctional CN neuron in flies, these animals experienced an imbalance, resulting in hyperglycemia – high levels of sugars in the blood, similar to what is observed in diabetes in humans. This further suggests that the CN neuron is critical to maintaining glucose homeostasis in animals. While further research is required to investigate this process in humans, Suh notes this is a significant step forward in the fields of both neurobiology and endocrinology. “This work lays the foundation for translational research to better understand how this delicate regulatory process is affected by diabetes, obesity, excessive nutrition and diets high in sugar,” Suh said. Profile: Greg Seong-Bae Suh seongbaesuh@kaist.ac.kr Professor Department of Biological Sciences KAIST (Figure: A single glucose-excited CN neuron extends bifurcated axonal branches, one of which innervates insulin producing cells and stimulates their activity an the other axonal branch projects to glucagon producing cells and inhibits their activity.)
2019.10.24
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