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KAIST Partners with Technion and Hyundai Motors for Future Mobility Technology Development
(KAIST Associate Vice President of Research Joung-Ho Kim(third from left) poses with Technion President Pereta Lavie and CTO Tae Won Im of Hyundai Motors)
KAIST has partnered with the Israel Institute of Technology, Technion, and Hyundai Motors to take the lead in the field of future mobility technologies. The three parties signed a consortium of global alliance for future mobility partnership at Technion on Sept. 5. KAIST Associate Vice President of Research Kim Joung-Ho, Hyundai Motor’s Central Advanced Research and Engineering CTO Tae Won Lim, and Technion President Peretz Lavie signed the MOU.
The three parties agreed to conduct joint research on hi-tech mobility areas including self-driving systems, cyber security, and AI in mobility. With the signing of the consortium, KAIST's technology in AI, semiconductors, and autonomous cars will produce synergy with Technion’s connected car solutions, advancing Hyundai Motor's competitiveness in the future mobility market.
In addition to the consortium, the three parties will set-up a startup consulting committee, which will provide consulting services for nurturing venture startups with creative ideas and outstanding technological prowess in their host countries.
2017.09.07 View 5397 -
KAIST AI Academy for LG CNS Employees
The Department of Industrial & Systems Engineering (Graduate School of Knowledge Service Engineering) at KAIST has collaborated with LG CNS to start a full-fledged KAIST AI Academy course after the two-week pilot course for employees of LG CNS, a Korean company specializing in IT services.
Approximately 100 employees participated in the first KAIST AI Academy course held over two weeks from August 24 to September 1. LG CNS is planning to enroll a total of 500 employees in this course by the end of the year.
Artificial intelligence is widely recognized as essential technology in various industries. In that sense, the KAIST AI Academy course was established to reinforce both the AI technology and the business ability of the company. In addition, it aims at leading employees to develop new business using novel technologies. The main contents of this course are as follows: i) discussing AI technology development and its influence on industries; ii) understanding AI technologies and acquiring the major technologies applicable to business; and iii) introducing cases of AI applications and deep learning.
During the course, seven professors with expertise in AI deep learning from the Department of Industrial & Systems Engineering (Graduate School of Knowledge Service Engineering), including Jae-Gil Lee and Jinkyoo Park will be leading the class, including practical on-site educational programs.
Based on the accumulated business experience integrated with the latest AI technology, LG CNS has been making an effort to find new business opportunities to support companies that are hoping to make digital innovations.
The company aims to reinforce the AI capabilities of its employees and is planning to upgrade the course in a sustainable manner. It will also foster outside manpower by expanding the AI education to its clients who pursue manufacturing reinforcement and innovation in digital marketing.
Seong Wook Lee, the Director of the AI and Big Data Business Unit said, “As AI plays an important role in business services, LG CNS decided to open the KAIST AI Academy course to deliver better value to our clients by incorporating our AI-based business cases and KAIST’s up-to-date knowledge.”
2017.09.06 View 6554 -
KAIST to Open the Meditation Research Center
KAIST announced that it will open its Meditation Research Center next June. The center will serve as a place for the wellness of KAIST community as well as for furthering the cognitive sciences and its relevant convergence studies.
For facilitating the center, KAIST signed an MOU with the Foundation Academia Platonica in Seoul, an academy working for enriching the humanities and insight meditation on Aug.31. The Venerable Misan, a Buddhist monk well-known for his ‘Heart Smile Meditation’ program, will head the center.
The center will also conduct convergence research on meditation, which will translate into brain imaging, cognitive behavior, and its psychological effects. Built upon the research, the center expects to publish textbooks on meditation and will distribute them to the public and schools in an effort to widely disseminate the benefits of meditation.
As mindful meditation has become mainstream and more extensively studied, growing evidence suggests multiple psychological and physical benefits of these mindfulness exercises as well as for similar practices. Mind-body practices like meditation have been shown to reduce the body’s stress response by strengthening the relaxation response and lowering stress hormones.
The Venerable Misan, a Ph.D in philosophy from Oxford University, also serves as the director of the Sangdo Meditation Center and a professor at Joong-Ang Sangha University, a higher educational institution for Buddhist monks.
Monk Misan said that meditation will play a crucial part in educating creative students with an empathetic mindset. He added, “Hi-tech companies in Silicon Valley such as Google and Intel have long introduced meditation programs for stress management. Such practices will enhance the wellness of employees as well as their working efficiency.”
President Sung-Chul Shin said of the opening of the center, “From long ago, many universities in foreign countries including Havard, Stanford, Oxfor universities and the Max Planck Institute in Germany have applied scientific approaches to meditation and installed meditation centers. I am pleased to open our own center next year and I believe that it will bring more diverse opportunities for advancing convergent studies in AI and cognitive sciences.
2017.08.31 View 5498 -
Discovery of an Optimal Drug Combination: Overcoming Resistance to Targeted Drugs for Liver Cancer
A KAIST research team presented a novel method for improving medication treatment for liver cancer using Systems Biology, combining research from information technology and the life sciences. Professor Kwang-Hyun Cho in the Department of Bio and Brain Engineering at KAIST conducted the research in collaboration with Professor Jung-Hwan Yoon in the Department of Internal Medicine at Seoul National University Hospital. This research was published in Hepatology in September 2017 (available online from August 24, 2017).
Liver cancer is the fifth and seventh most common cancer found in men and women throughout the world, which places it second in the cause of cancer deaths. In particular, Korea has 28.4 deaths from liver cancer per 100,000 persons, the highest death rate among OECD countries and twice that of Japan.
Each year in Korea, 16,000 people get liver cancer on average, yet the five-year survival rate stands below 12%. According to the National Cancer Information Center, lung cancer (17,399) took the highest portion of cancer-related deaths, followed by liver cancer (11,311) based on last year data.
Liver cancer is known to carry the highest social cost in comparison to other cancers and it causes the highest fatality in earlier age groups (40s-50s). In that sense, it is necessary to develop a new treatment that mitigates side effects yet elevates the survival rate.
There are ways in which liver cancer can be cured, such as surgery, embolization, and medication treatments; however, the options become limited for curing progressive cancer, a stage in which surgical methods cannot be executed.
Among anticancer medications, Sorafenib, a drug known for enhancing the survival rate of cancer patients, is a unique drug allowed for use as a targeted anticancer medication for progressive liver cancer patients. Its sales reached more than ten billion KRW annually in Korea, but its efficacy works on only about 20% of the treated patients. Also, acquired resistance to Sorafenib is emerging. Additionally, the action mechanism and resistance mechanism of Sorafenib is only vaguely identified.Although Sorafenib only extends the survival rate of terminal cancer patients less than three months on average, it is widely being used because drugs developed by global pharmaceutical companies failed to outperform its effectiveness.
Professor Cho’s research team analyzed the expression changes of genes in cell lines in response to Sorafenib in order to identify the effect and the resistance mechanism of Sorafenib.
As a result, the team discovered the resistance mechanism of Sorafenib using Systems Biology analysis. By combining computer simulations and biological experiments, it was revealed that protein disulfide isomerase (PDI) plays a crucial role in the resistance mechanism of Sorafenib and that its efficacy can be improved significantly by blocking PDI.
The research team used mice in the experiment and discovered the synergic effect of PDI inhibition with Sorafenib for reducing liver cancer cells, known as hepatocellular carcinoma. Also, more PDIs are shown in tissue from patients who possess a resistance to Sorafenib. From these findings, the team could identify the possibility of its clinical applications. The team also confirmed these findings from clinical data through a retrospective cohort study.
“Molecules that play an important role in cell lines are mostly put under complex regulation. For this reason, the existing biological research has a fundamental limitations for discovering its underlying principles,” Professor Cho said. “This research is a representative case of overcoming this limitation of traditional life science research by using a Systems Biology approach, combining IT and life science. It suggests the possibility of developing a new method that overcomes drug resistance with a network analysis of the targeted drug action mechanism of cancer.”
The research was supported by the National Research Foundation of Korea (NRF) and funded by the Ministry of Science and ICT.
(Figure 1. Simulation results from cellular experiments using hepatocellular carcinoma)
(Figure 2. Network analysis and computer simulation by using the endoplasmic reticulum (ER) stress network)
(Figure 3. ER stress network model)
2017.08.30 View 10489 -
The Medici Effect: Highly Flexible, Wearable Displays Born in KAIST
(Ph.D. candidate Seungyeop Choi)
How do you feel when technology you saw in a movie is made into reality? Collaboration between the electrical engineering and textile industries has made TVs or smartphone screens displaying on clothing a reality.
A research team led by Professor Kyung Cheol Choi at the School of Electrical Engineering presented wearable displays for various applications including fashion, IT, and healthcare. Integrating OLED (organic light-emitting diode) into fabrics, the team developed the most highly flexible and reliable technology for wearable displays in the world.
Recently, information displays have become increasingly important as they construct the external part of smart devices for the next generation. As world trends are focusing on the Internet of Things (IoTs) and wearable technology, the team drew a lot of attention by making great progress towards commercializing clothing-shaped ‘wearable displays’.
The research for realizing displays on clothing gained considerable attention from academia as well as industry when research on luminescence formed in fabrics was introduced in 2011; however, there was no technology for commercializing it due to its surface roughness and flexibility.
Because of this technical limitation, clothing-shaped wearable displays were thought to be unreachable technology. However, the KAIST team recently succeeded in developing the world’s most highly efficient, light-emitting clothes that can be commercialized.
The research team used two different approaches, fabric-type and fiber-type, in order to realize clothing-shaped wearable displays. In 2015, the team successfully laminated a thin planarization sheet thermally onto fabric to form a surface that is compatible with the OLEDs approximately 200 hundred nanometers thick. Also, the team reported their research outcomes on enhancing the reliability of operating fiber-based OLEDs. In 2016, the team introduced a dip-coating method, capable of uniformly depositing layers, to develop polymer light-emitting diodes, which show high luminance even on thin fabric.
Based on the research performance in 2015 and 2016, Ph.D. candidate Seungyeop Choi took the lead in the research team and succeeded in realizing fabric-based OLEDs, showing high luminance and efficiency while maintaining the flexibility of the fabric.
The long-term reliability of this wearable device that has the world’s best electrical and optical characteristics was verified through their self-developed, organic and inorganic encapsulation technology. According to the team, their wearable device facilitates the operation of OLEDs even at a bending radius of 2mm.
According to Choi, “Having wavy structures and empty spaces, fiber plays a significant role in lowering the mechanical stress on the OLEDs.”
“Screen displayed on our daily clothing is no longer a future technology,” said Professor Choi. “Light-emitting clothes will have considerable influence on not only the e-textile industry but also the automobile and healthcare industries.”
Moreover, the research team remarked, “It means a lot to realize clothing-shaped OLEDs that have the world’s best luminance and efficiency. It is the most flexible fabric-based light-emitting device among those reported. Moreover, noting that this research carried out an in-depth analysis of the mechanical characteristics of the clothing-spared, light-emitting device, the research performance will become a guideline for developing the fabric-based electronics industry.”
This research was funded by the Ministry of Trade, Industry and Energy and collaborated with KOLON Glotech, INC. The research performance was published in Scientific Reports in July.
(OLEDs operating in fabrics)
(Current-voltage-luminance and efficiency of the highly flexible, fabric-based OLEDs;Image of OLEDs after repetitive bending tests;Verification of flexibility through mechanical simulation)
2017.08.24 View 13867 -
Global ITTP Graduates 12 Public Officials from 11 Countries
The 18th Global Information and Telecommunication Technology Program (ITTP) graduated 12 public officials from 11 countries in a commencement ceremony held on August 23.
Distinguished guests, faculty, and family of graduates including President Sung-Chul Shin, the Chair of the School of Business and Technology Youngsun Kown, and the Director of Global ITTP Jaejung Rho attended the commencement. Ghana Ambassador Joseph Agoe, Mrs. Lyudmila Fen, the spouse of Uzbekistan Ambassador Vitali Fen, and other dignitaries came to congratulate the 12 master’s students on their successful graduation.
The Global ITTP was launched in 2006 and offers customized master’s and doctoral degree programs to elite public officials from diverse countries on information and communication technology. This program plays a vital role for transferring Korea’s advanced ICT to countries whose industries are in the budding stages. Since 2006, the program has produced 181 alumni (48 PhDs and 133 masters) from 60 countries.
In his congratulatory message during the ceremony, President Shin congratulated the graduates on the long journey they had been through while completing their courses and welcomed the newest addition of KAIST 12 alumni.
“Back in the 1960s, Korea was one of the poorest countries in the world. Korea’s GDP stood at less than 100 US dollars. Through it all, Korean companies are now taking the lead in the global high-tech market, emerging as movers and shakers. I believe that ‘VIP’ changed it all; in other words, visionary leaders, innovative ideas, and passionate people all combined to make the difference in Korea,” said President Shin.
He also shared a new formula for success in the wake of the new industrial environment of the Fourth Industrial Revolution with the graduates who will soon begin a new ambitious professional journey in their countries. “I think Innovation, Collaboration, and Speed will be the key words to make a difference in every sector of each and every country in this dynamic new era. When making a national development strategies, please keep in mind ‘ICS’ for the development of your country as well as the world’s sustainable development.”
Finally, he said, “As a KAIST alumnus, always be sincere wherever you work and whatever you do during your service. I advise you to become a leader who is doing one’s best at all times.”
☞ Link to the 18th commencement address
2017.08.24 View 6147 -
Solutal Marangoni Flows of Miscible Liquid Drive Transport without Surface Contamination
(Professor Hyoungsoo Kim, Department of Mechanical Engineering, KAIST)
A research team led by Hyoungsoo Kim, a professor of Mechanical Engineering at KAIST, succeeded in quantifying the phenomenon called, the Marangoni effect, which occurs at the interface between alcohol and water. It is expected that this finding will be a valuable resource used for effectively removing impurities from a surface fluid without any contamination, and developing materials that can replace surfactants.
This research, co-conducted with a research team led by Professor Howard A. Stone at Princeton University, was published online in Nature Physics on July 31.
The Marangoni effect, also known as tears of wine, is generated when two fluids having a different surface tension meet, causing finite mixing, spreading time and length scale. Typically, people believe that infinitely miscible liquids immediately mix together; however, it is not always true according to this paper.
The typical surface tension of alcohol is three times lower than that of water, and this different surface tension generates the Marangoni-driven convection flow at the interface of the two liquids. In addition, there is a certain amount of time required for them to mix.
This phenomenon has been discussed many times since it was discovered in early the 20th century, yet there was a limit to quantifying and explaining it.
Professor Kim, considering the mixing and spreading mechanism, used various flow visualization techniques and equipment for capturing high speed images in his experiment.
Through the flow visualization methods, the team succeeded in quantifying and explaining the complex, physicochemical phenomenon generated between water and alcohol. Moreover, they developed a theoretical model to predict the physicochemical hydrodynamic phenomena.
The theoretical model can predict the speed of Marangoni-driven convection flow, the area of a drop of alcohol and the time required to develop the flow field. Hence, this model can map out types of materials (e.g., alcohol) and the volume of a drop of liquid as applicable to target a specific situation.
Moreover, the research team believes that the interfacial flow enables the driving of bulk flows and that it can be a source of technology for effectively delivering drugs and removing impurities from a surface of substance without causing secondary contamination.
Above all, the results show a possibility for replacing surfactant with alcohol as a material used for delivering drugs. In the case of the drug delivery, some drugs are encapsulated with a surfactant in order to be effectively transported in vivo; however, the surfactant accumulates in the body, which can cause various side effects, such as heart disease. Therefore, using new materials like alcohol for drug delivery will contribute to preventing the side effects caused by the surfactant.
“The surfactant is used for delivering drugs, but it is difficult to be expelled from the body. This will cause various side effects, such as heart diseases in asthmatic patients,” said Professor Kim. “I hope that using new materials, like alcohol, will free people from these side effects.”
(Marangoni-driven convection flow generated at the interface between water and alcohol, and the flow visualization results)
- A drop of alcohol on a water surface
- Comparison of mixing structures on the surface
- Marangoni mixing flow under the free surface
2017.08.18 View 7452 -
Professor Dan Keun Sung Endows Scholarship in Honor of His Retirement
Professor Dan Keun Sung in the School of Electrical Engineering contributed a 100 million KRW scholarship fund this month to KAIST to mark his retirement after more than three decades of work.
“As my retirement date comes closer, I have been thinking about what I could do for the school. I wanted to leave something behind, even though it’s small, for my lifelong school and students. I am hoping that this scholarship fund will benefit the members of KAIST.”
This isn’t his first time making a donation to KAIST. In 2013, Professor Sung donated ten million KRW, which was his cash prize from the 9th Haedong Academic Award of The Korean Institute of Communications and Information Sciences (KICS). At that time, Professor Sung had the chance to create a scholarship fund in his name; however, he wanted to highlight that the scholarship fund was for ‘someone,’ not created by ‘someone.’ In that sense, his scholarship fund was created with no name to benefit students in the School of Electrical Engineering. His colleagues and students supported his idea. Professor Seonghwan Cho, students, and alumni also participated in fund raising efforts, which reached 55 million KRW in total.
Professor Sung emphasized, “Donations should always be remembered, no matter how small they are.” He then explained his purpose for creating the scholarship fund by saying, “Fundraising can be truly meaningful to contributors, knowing that their money is going to supporting the school and students.”
Professor Sung, a fellow of the Institute of Electrical and Electronics Engineers (IEEE) Communication Society, started his post at KAIST in 1986. For the past 30 years, he has devoted himself to fostering young scholars and studying in the area of information and communication. He also participated in developing technologies for the resource management of various future cellular components, such as satellites, switchboards, and signaling networks.
2017.08.11 View 7977 -
Analysis of Gas Adsorption Properties for Amorphous Porous Materials
Professor Jihan Kim from the Department of Chemical and Biomolecular Engineering at KAIST has developed a method to predict gas adsorption properties of amorphous porous materials.
Metal-organic frameworks (MOFs) have large surface area and high density of pores, making them appropriate for various energy and environmental-related applications. And although most MOFs are crystalline, these structures can deform during synthesis and/or industrial processes, leading to loss in long-range order. Unfortunately, without the structural information, existing computer simulation techniques cannot be used to model these materials.
In this research, Professor Kim’s research team demonstrated that one can replace the material properties of structurally deformed MOFs with those of crystalline MOFs to indirectly analyze/model the material properties of amorphous materials. First, the team conducted simulations on methane gas adsorption properties for over 12,000 crystalline MOFs to obtain a large training set data, and created a resulting structure-property map. Upon mapping the experimental data of amorphous MOFs onto the structure-property map, results showed that regardless of crystallinity, the gas adsorption properties of MOFs showed congruence and consistency amongst one another.
Based on these findings, selected crystalline MOFs with the most similar gas adsorption properties as the collapsed structure from the 12,000 candidates. Then, the team verified that the adsorption properties of these similar MOFs can be successfully transferred to the deformed MOFs across different temperatures and even to different gas molecules (e.g. hydrogen), demonstrating transferability of properties.
These findings allow material property prediction in porous materials such as MOFs without structural information, and the techniques here can be used to better predict and understand optimal materials for various applications including, carbon dioxide capture, gas storage and separations.
This research was conducted in collaboration with Professor Dae-Woon Lim at Kyoto University, Professor Myunghyun Paik at Seoul National University, Professor Minyoung Yoon at Gachon University, and Aadesh Harale at Saudi Arabian Oil Company. The research was published in the Proceedings of the National Academy of Sciences (PNAS) online on 10 July and the co-first authors were Ph. D. candidate WooSeok Jeong and Professor Dae-Woon Lim.
This research was funded by the Saudi Aramco-KAIST CO2 Management Center.
(Figure 1. Trends in structure - material property map and in collapsed structures)
(Figure 2. Transferability between the experimental results of collapsed MOFs and the simulation results of crystalline MOFs)
2017.07.26 View 8561 -
KAIST to Host the 2017 AI World Cup in November
KAIST, the birthplace of the Robot World Cup in 1996, now presents a new technology matchup, the AI World Cup this November, which will be held at KAIST. The event is being organized by the Machine Intelligence and Robotics Multi-Sponsored Research and Education Platform (MIR-MSREP) of KAIST. The online, simulated AI soccer game, based on rolling updates, will be a draw for avid online gamers and tech-savvy university students from around the nation.
The tournament is comprised of three events: ▲A 5 on 5 AI soccer match to be played after self-learning using AI technology in an online simulation environment ▲Commentary in which online soccer videos are analyzed and commented on, and ▲Game reporters who will write articles on online soccer event results.
The participants will undergo a month-long online practice period in October and compete in preliminary matches from November 1 through 24. The top teams that scored the highest accumulated points will compete in the finals on December 1. In the finals, each team’s AI technology implementation method will be evaluated to select the final winning team. To ensure a successful event, KAIST will host a briefing session for participants on July 28.
Technological prowess and early exposure to AI accumulated at KAIST led to the launching of this tournament. Professor Jong-Hwan Kim, the chair of the Organizing Committee of the AI World Cup, hosted the first ever Robot World Cup back in 1996. His concept has now evolved into the emerging technology of AI and the members of the Organizing Committee encompass the professors from the various departments of electrical engineering, computing, industrial and systems engineering, aerospace engineering, civil and environmental engineering, and the graduate schools of Green Transportation, Cultural Technology, and Science and Technology Policy.
In particular, ongoing convergence research initiatives incorporating AI into a wide arrays of disciplines such as bio, nano, and IT, played a crucial role for making this AI World Cup happen. Professor Kim said, “The winner of this year’s competition will be awarded a certificate and a small gift. In 2018, we aim to expand the event to an international scale by allowing international teams.”
Any undergraduate or graduate student in Korea can apply to participate in the ‘AI World Cup 2017’. KAIST will host a public trial event during the ‘Open KAIST’ event period to be held November 2-3 to help participating students understand the event better. ‘Open KAIST’ allows the general public to personally visit and experience what goes on in engineering departments and laboratories on the KAIST main campus. It is hosted by the College of Engineering every two years and is the largest event hosted by KAIST.
To participate in the ‘AI World Cup 2017,’ teams consisting of Korean undergraduates or graduate students can fill out application forms and submit them by September 30 on http://mir.kaist.ac.kr .
2017.07.14 View 9927 -
Structural Insights into the Modulation of Synaptic Adhesion by MDGA for Synaptogenesis
Synapses connected by various synaptic adhesion molecules are communication spaces between neurons for transmitting information. Among various synaptic adhesion molecules, neuroligins are arguably the most widely studied class of postsynaptic adhesion molecules, which mainly interact with presynaptic neurexins to induce excitatory or inhibitory synapse development. Recently, the membrane-associated mucin (MAM) domain-containing GPI anchor protein 1 (MDGA1) has been characterized as a key suppressor of Neuroligin-2/Neurexin-1β-mediated inhibitory synapse development, but how it acts remains a mystery.
In a recent issue of Neuron, published on June 21, 2017, a research team led by Professor Ho Min Kim at the Graduate School of Medical Science and Engineering of KAIST reported the three-dimensional structure of MDGA1/Neuroligin-2 complex and mechanistic insights into how MDGAs negatively modulate synapse development governed by Neurexins/Neuroligins trans -synaptic adhesion complex.
MDGA1 consists of six Ig-like domains, fibronectin type III repeat domain, and MAM domain . The crystal structure of MDGA1/Neuroligin-2 complex reveals that they form the 2:2 hetero-tetrameric complex and only the Ig1-Ig2 domains of MDGA1 are involved in interactions with Neuroligin-2. The structural comparison between the MDGA1/Neuroligin-2 and Neurexin-1β/Neuroligin-1 complexes intriguingly indicates that the Neuroligin-2 region binding to MDGA1 largely overlaps with that of Neurexin-1β, but the interaction interface of the MDGA1/Neuroligin-2 complex is much larger than that of the Neurexin-1β/Neuroligin-1 complex. This explains why Neuroligin-2 binds stronger to MDGA1 than Neurexin-1β, and how the favored MDGA1 binding to Neuroligin-2 sterically blocks the interaction between Neuroligin-2 and Neurexin-1β, which is critical for the suppression of inhibitory synapse development.
“Although we found that MDGA Ig domains (Ig 1 and Ig 2) are sufficient to form a complex with NL2, other extracellular domains, including Ig 3–6, FN III, and MAM domains, may also contribute to stable cis-interactions between MDGA1 and Neuroligin-2 by providing conformational flexibility. Therefore, further structural analysis of full-length MDGA will be required,” Professor Kim said.
Neuroligin-2 specifically promotes the development of inhibitory synapses, whereas neuroligin-1 promotes the development of excitatory synapses. Recently, not only MDGA1, but also MDGA2 have emerged as synaptic regulators for the development of excitatory or inhibitory synapses. In vitro biochemical analysis in this research clearly demonstrates that Neuroligin-1 and Neuroligin-2 bind to both MDGA1 and MDGA2 with comparable affinity. However, pull-down assays using detergent-solubilized mouse brain membrane fractions show the specific interaction of MDGA1 with Neuroligin-2, but not with Neuroligin-1. “This suggests that unidentified processes may dictate the selective association of MDGA1 with Neuroligin-2 in vivo , ” explained Professor Jaewon Ko at the Daegu Gyeongbuk Institute of Science and Technology (DGIST).
A balance between excitatory and inhibitory synapses is crucial to healthy cognition and behavior. Mutations in neuroligins, neurexins, and MDGAs, which can disrupt the excitatory/inhibitory balance, are associated with neuropsychiatric diseases such as autism and schizophrenia. Jung A Kim at KAIST, first author in this study, said, “Our discovery from integrative investigations are an important first step both for a better understanding of Neuroligin/Neurexin synaptic adhesion pathways and MDGA-mediated regulation of synapse development as well as the development of potential new therapies for autism, schizophrenia, and epilepsy.”
2017.07.10 View 7949 -
President Shin Shares His Biggest Challenges, Success, and New Mission
President Sung-Chul Shin talks on his biggest challenges, successes, and new mission in an interview with Times Higher Education on June 29. Followings are the full text of the interview.
▶ What are the unique challenges and advantages of being a university in the Asia-Pacific region?
Globalization is definitely the biggest challenge. KAIST has made strenuous institutional efforts to address this issue for decades. Globalization is not just about language issues, especially for an Asian university. There are still lingering cultural barriers. However, we are improving and seeing significant progress. Approximately 85 per cent of our classes are being lectured in English, and my ultimate goal is to make KAIST a bilingual campus for a more globalized environment.
Speaking of advantages, we can recruit top-quality students from neighboring countries.
▶ What role do universities have in creating social equality?
I strongly believe that education is an essential means of empowerment and social mobility. KAIST has diligently promoted policies to help ensure greater diversity, without discriminating against anyone’s talents on the basis of gender, race, or background.
We implement an equal opportunity admission system, with special consideration given to the underprivileged, geographically-excluded groups, North Korean refugees, and many other disadvantaged groups. We recruit five percent of our freshmen from these groups under our admission system annually.
As for the gender gap, our female student population is now over 25 per cent, and we expect in the very near future the ratio will increase up to 30 percent. However, female faculty ratio stands at around 10 per cent, so we will attempt to double the ratio soon.
In addition, we work to emphasize social responsibility to our students. They are a privileged group, so they should be responsible for giving back their knowledge and talents to society in diverse ways. I am very glad that many of our students engage in the social entrepreneurship programs we are running now. That will be fruitful for ensuring social equity as well as making society better.
▶ What is the most important issue affecting your university right now?
KAIST has now emerged as a world-class university and one of the most innovative universities in the Asia-Pacific region. However, building on our new reputation as a "world-leading" university remains a big challenge. As the first and top research university in Korea, KAIST has been the gateway to the advancement of science and technology and innovation.
We are now responsible for taking the lead in creating new knowledge that will make a global impact. This is the momentum we need to make another quantum leap to become the university which creates the most global value.
▶ There is a great pressure in Korea for young people to get into a “top” university. Is this pressure on school students too great?
Traditionally, going to a top school was deemed the ladder to success in life. We went through the economically tough times in which diverse groups of occupations had never existed before. As a result, competition between individuals was incredibly high to get into good school and good company.
It is true that such social pressure occupied thoughts of many young students and their parents. In effect, that was also the driving force for achieving Korea’s economic growth in a relatively short period of time. But things are changing now.
We are living in a complex global economic environment. The number of new occupations creates new knowledge and new types of jobs. Even more, this new era changed the conventional paradigm of jobs and success. Successful careers take collaboration, and one must seek whom to work with, where you fit, and what you will do and how you can reach your potential.
This change of perception has begun to transform the general definition of a successful life. The government and educational institutions are working to reflect new socio-economic trend to maximize students’ creativity and their own uniqueness in many educational institutions.
However, strong competition to get into a top university seems to be a universal problem - as is also the case for the Ivy League in the US and many other regions.
▶ South Korean universities have some of the closest links to industry. Is a lot of your job about building relationships with companies rather than focusing on educational issues?
The relationship with industry is increasingly significant, and collaboration is very important in Korea. It is a crucial source for securing students’ jobs. On top of that, we get research funding from companies and supply the pipeline of new inventions and innovation for them, in many case through collaboration projects. That could also be interpreted as our reputation of institutional performance through diverse evaluation indicators.
From the industry side, we are a very good supplier of high-caliber manpower. Therefore, a solid relationship with industry is key to the creation of added value of knowledge, as well as a critical steppingstone for technology commercialization.
Therefore, scaling up the organic relationship with industry is part of our education and research portfolio as well as part of my job as president.
▶ Do you think the main role of universities is to prepare graduates for the world of work?
The role of higher education is to educate the future generation and create new knowledge though research. The conventional concept of research and development (R&D) has expanded to R&DB, as it now includes business. Thus, the role of a university is also evolving. Universities should provide diverse opportunities for graduates to prepare them to contribute to society. That will be one of the ways to realize the social responsibility of a university.
▶ If someone else was taking over your role tomorrow, what’s the most useful advice you could give them?
When I took the office in March, I made up my mind to serve our students, faculty and staff with all my heart. I would say, inspire your people with leadership that they can emotionally connected with, if possible. In addition, I think only professionalism can make the best professionals.
▶ Who has inspired you during your career?
Dr. Kun-Mo Chung, former vice president of KAIST and former minister for science and technology, is my role model and mentor. He is an internationally renowned nuclear engineer and scholar, and successful technocrat who served as the minister for science and technology twice. He still teaches at KAIST in his eighties.
I admired his visionary leadership and his successful career as administrator as well as accomplished scholar. After graduating from Seoul National University, he went to Michigan State University. In his early thirties, he came back to Korea as a member of the United States Agency for International Development survey team to conduct the feasibility study for founding KAIST. He wrote the proposal in the Terman Report to the USAID that the establishment of KAIST would be necessary and useful for Korea. With $6 million dollar loan from the agency, he founded KAIST. He is the true innovator, I think.
▶ How do you use data to make sure your university is performing well? We are analyzing the diverse data released from international evaluation institutions such as THE data and Clarivate Analytics, as well as domestic institutions. Through the various indicators of data, we are keen to realize the global standard of our institution and advance our innovation competitiveness at a global level.
2017.07.06 View 6060