Science
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Professor Eunjoon Kim's team finds synapse-forming protein
Professor Eunjoon Kim’s team finds synapse-forming protein
- discover a new protein ‘NGL’ that promotes the formation of neuronal synapses
- can presume the cause of various brain disorders including schizophrenia
- will be published at Nature Neuroscience Vol. 9 in September
A new protein that promotes the formation of synapses in human brains was discovered by a Korean research team.
The team led by Eunjoon Kim, Professor of Department of Biological Sciences and Head of Creative Research Group of Synapse Formation), announced that it had discovered a new fact that NGL protein promotes the formation of neuronal synapses and this fact would be published in Nature Neuroscience Vol. 9 on September 18.
Professor Kim’s team discovered that a membrane protein named ‘NGL’ located at post synapse links with other membrane protein named netrin-G in pre synapse, acting as crosslink, and promotes the formation of a new synapse.
‘NGL’ is the second protein found to crosslink synapse, following neuoroligin. With the discovery of this new protein, the principle of synapse formation and the causes of various brain disorders can be presumed.
In the human brain, about more than 100 billion neuron cells and about 10,000 synapses compose neural circuit. A synapse is the place where innervation occurs between neuron cells. The formation of synapse induces the formation of neural circuit, and neural circuit is deeply related with various brain disorders as well as normal development of brains or brain functions.
“As netrin-G linked with NGL is related with schizonphrenia and neuoroligin and synapse crosslinking protein having a similar function with NGL is deeply related with mental retardation and autism, I think NGL is related with various brain disorders including schizophrenia.”
<Explanation of attached photos>
■ Photo1: Experiment for confirming NGL’s ability to form synapse No. 1
Mix ordinary cell (green) revealing NGL at its surface and neuron cell. Axon grows toward NGL (ordinary cell) located in the middle of ten o’clock direction and meets NGL, where NGL induces the formation of pre synapse (red) in the contacting axon.
Whether pre synapse has been formed can be told by the fluorescent dying (red) of pre synapse protein named Synapsin.
- Figure a-b: formation of synapse by NGL
- Figure c-d: transformed NGL losing synapse forming ability cannot form synapse
■ Photo 2: Experiment for confirming NGL’s ability to form synapse No. 2
When beads coated with NGL are scattered on neuron cell, the beads contact with the axon of the neuron cell (the beads are clearly visible at the phase differentiation image in the middle panel). At this time, NGL induces the formation of pre synapse (red) in the axon. Whether pre synapse has been formed can be told by the fluorescent dying (red) of pre synapse protein named SynPhy (panel a) or VGlut1 (panel b).
2006.09.21 View 14785 -
KAIST Cultural Festival - the 2nd rocklassic
KAIST Cultural Festival - the 2nd rocklassic
- Unique music festival by KAIST students mixed with creation, performance, and science
- Result of creative classes - All activities from performance planning to strings manufacturing will be carried out by students themselves
- At the outdoor theater in KAIST, 7:30 p.m. Sunday, September 10
Crossover music festival pursuing balanced mixture of Rock and Classic will be held by KAIST students.
KAIST (President Nam-Pyo Suh) will open ‘KAIST Cultural Festival - the 2nd rocKlassic’ at the outdoor theater, 7:30 p.m. Sunday, September 10.
This performance can be considered as a new attempt that provides opportunities of experiencing the vital topic of industry in the 21st century - fusion of culture and technology. Performance planning, arrangement, and playing are all carried out by students themselves, and musical instruments manufactured by students during classes will be used for the performance. This performance is the result of creative classes such as chamber music, strings manufacturing, performance planning, and business management, which have been newly attempted in KAIST since 2002.
In the performance subtitled as ‘Einstein’s Violin’, KAIST-graduated bandoneonist Sangji Ko will play the bandoneon (musical instrument which is composed of rectangular side faces and wrinkled box, and played by pushing buttons) as a special guest, and total 40 players including members of KAIST student music club ‘Adlib’, ‘KAIST orchestra’, and ‘MUSIKA’, which is making active performances outside KAIST, will attend to make the concert the biggest music project of KAIST.
General director Jeongjin Kim (Professor of KAIST Graduate School of Culture and Technology) said, “In order to enjoy the concert with neighborhood, the outdoor theater capable of 3,000 people will be fully opened, and there is no charge for it. I am sure the passion and talent toward music emitting from KAIST students will startle the audience.”
■ Program
<1st stage>
- The song of life - Adlib, KAIST orchestra
- Flying - Adlib, KAIST orchestra
- From between calm and passion - Chulho Kim, KAIST orchestra
- Propose - Yeoseotjul
- As my wish - Yeoseotjul, Adlib
- I lay my love on you - Yeoseotjul
- Rachmaninov/ Rhapsody on Theme of Paganini Op. 43: Var. 18 Piano - Chulho Kim, KAIST orchestra
- Chaser - Adlib
- Walk this way - Adlib
- Girl’s period - Adlib
- Sweep away - Adlib, KAIST orchestra
<2nd stage>
- Beethoven Virus - Adlib, KAIST orchestra
- Simple symphony - KAIST orchestra
- Cinema paradiso - KAIST orchestra
- Piano trio by Mendelssohn - Daehyun Wie (Piano), Wontae Song (Violin), Hongje Chang (Cello)
- Tango Pugata - Sangji Ko (Bandoneonist), etc.
- Vuelvo al sur - Youngsan Lee, etc.
- La Cumparsita - Sangji Ko, etc.
- Libertango - Sangji Ko, etc.
- Dramatic Funk - Wontae Song, Adlib
- Cavalleria rusticana intermezzo - Sangji Ko, KAIST orchestra
- Hurricane 2000 - Adlib, KAIST orchestra, Yeoseotjul
2006.09.11 View 14815
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Professor Tae-Gwan Park awarded Minister Prize
Professor Tae-Gwan Park awarded Minister Prize
Professor Tae-Gwan Park (Department of Biological Sciences) was awarded the Minister Prize in the science innovation sector at the NANO KOREA 2006, which was opened on August 30.
This prize is given to researchers who have shown excellent research results in the field of Nanotechnology, and Professor Park was awarded the Minister Prize in recognition of his innovative achievements in the fields of Tissue Engineering, Drug Delivery, Gene Therapy, which are fusion technologies of NT and BT that utilize nanobiomaterials.
2006.09.06 View 14071
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Professor Ryong Ryoo, selected as a scientist wished to resemble and to be 2006
Professor Ryong Ryoo, selected as a scientist wished to resemble and to be 2006
Professor Ryong Ryoo (Department of Chemistry) was selected as a scientist wished to resemble and to be 2006.
Professor Ryoo developed in 2000 world’s first nanoporous carbon material in which numberless several nanometer-sized holes were drilled. The development of this nanoporous material was introduced by international scientific journal NATURE in 2000 and 2001 and expected to contribute to the progress of mankind through the development of high efficiency fuel cell or ultra-light computer. Professor Ryoo also developed a new technology that can considerably improve the catalyst activation and stability of ‘Zeolite’, a main catalyst in the petrochemical industry, which was introduced by NATURE materials. The above achievements qualified Professor Ryoo for the selection.
‘Scientists wished to resemble and to be 2006’ were selected among scientists showing vigorous activities in the science and technology circle on the basis of their recent achievements, etc. by the Ministry of Science and Technology and the Korea Science Foundation, and total 10 scientists qualified to be the model of children and the youth were announced on August 24.
2006.09.06 View 14309
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Gene Protecting Brain Nerves Discovered
THE KOREA TIMES 2005.1.31By Kim Tae-gyu / Staff Reporter
South Korean scientists have for the first time discovered genes tasked with protecting brain nerves.
Korea Advanced Institute of Science and Technology professor Kim Jae-seob said Sunday the new genes, named pyrexia, shield brain nerves from outside stimuli, including high temperatures.
``The channel gene of pyrexia will open the door to developing new-concept medicines for brain damage in patients of high fever or drug addicts,’’ he said.
The channel gene refers to transport proteins, which provide a static passageway for a variety of essential substances to enter into cells.
``Up until now, a lot of channel genes activated by temperatures have been identified. But among them, pyrexia is first that guards brain nerves from external stresses,’’ Kim said.
Kim’s team learned pyrexia plays a pivotal role in the body through experiments with genetically engineered flies that did not have any pyrexia.
Up to 60 percent of the pyrexia-depleted mutants were paralyzed within three minutes of exposure to a temperature of 40 degrees Celsius.
In comparison, just 9 percent of normal flies were paralyzed with the same stimulus, indicating pyrexia is responsible for protecting animals from high-temperature stress.
``Our next goal is to develop pyrexia-embedded drugs, which can be expected to commercially debut in about five years,’’ Kim said.
Kim has already applied for international patents for his medical breakthrough, which will be printed in the March edition of Nature Genetics, a science journal.
voc200@koreatimes.co.kr
2005.02.02 View 13996
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Nerve-protecting gene discovered
Korean scientists for the first time have identified a gene that blocks nerve damage from fevers and the use of narcotics, a state-run research institute said yesterday.
The finding may open the way for new medicine that can prevent the loss of brain function which is frequently caused by excessive stimulation of nerves and abnormally high body temperature.
"The research is in an early stage. But this approach has the potential to develop genetics-based preventatives against brain-attacking diseases," said Kim Jae-seob, a bioscience professor of the Korea Advanced Institute of Science and Technology, who led the study.
The researchers named the gene Pyrexia, which means fever. Kim"s team extracted it from genetically engineered fruit flies using a genome-screening system. In laboratory tests, they found that the gene is activated to 39 degrees Celsius or higher.
The researchers enhanced Pyrexia"s functionality in some fruit flies while removing the gene from others to observe their different reactions when exposed to high temperature.
"The fruit flies without the gene showed severe nerve disorder and suffered paralysis of brain function, while Pyrexia-enhanced flies maintained their normal brain conditions," the professor said.
The researchers got the same result from experiments with human cells, he said.
There are a lot of channel proteins, which enable ions to enter and exit the cell, that react to the level of temperature, but Pyrexia is the first of its kind that actually protects the neurons from external stimulus, he said.
The finding will appear on the March edition of the London-based science magazine Nature Genetics.
THE KOREA HERALD 2005.1.31 (thkim@heraldm.com) By Kim Tong-hyung
2005.02.02 View 13870
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Nobel Laureate Heads KAIST
Nobel Laureate Heads KAIST
By Kim Tae-gyu / Staff Reporter
THE KOREA TIMES 05-29-2004
A Nobel laureate will lead the Korea Advanced Institute of Science and Technology (KAIST), winning a stiff race with a pair of strong Korean candidates.
The KAIST on Friday said the state-financed institute appointed Robert Laughlin as its 12th president instead of two local hopefuls, professors Shin Seong-cheol and Park Seong-ju.
This is the first time that foreigners take charge of the KAIST since it was established in 1971 and Laughlin also is noted in the history as the first Nobel Prize winner to head Korea"s educational institute.
After receiving approval of Science-Technology Minister Oh Myung, Laughlin will be inaugurated as early as next month, according to a KAIST official.
Laughlin, a Stanford professor, made his name after being co-awarded the 1998 Nobel Prize in Physics with Horst Stoermer and Daniel Tsui for the discovery of a new form of quantum fluid.
The findings, which explained the fractional quantum hall effect for the first time, have been recognized as a significant breakthrough in understanding quantum physics.
The American physicist had also sustained a special connection with Korea even before he garnered the prestigious prize and has visited Korea several times.
Early last month, Laughlin was named to head the Asia Pacific Center for Theoretical Physics (APCTP) in recognition of his notable interest in Korea.
The APCTP is an international research institute headquartered inside Pohang University of Science and Technology in North Kyongsang Province.
voc200@koreatimes.co.kr
2004.05.31 View 17103
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Professor Kim Donates W5 Bil. to KAIST
Korea Times 2004.5.21
By Kim Tae-gyu / Staff Reporter
A professor from the Korea Advanced Institute of Science and Technology (KAIST) has donated his inherited wealth of 5 billion won to the state-owned institute.
The KAIST announced professor Kim Dong-won contributed 5 billion won in properties and cash, which he inherited from his father, who passed away late last year.
``Professor Kim has asked us to spend the contribution in the development of Korea’s science in accordance with the late Kim’s will,’’ said Park Jae-wook, a KAIST spokesman.
Park added Kim had tried to remain anonymous, but his identity was revealed by some local newspapers. Kim is currently in the United States as he is out of his post on an interim basis and will come back to Korea in August.
Four billion won of the donation will be used to set up scholarships, which will endow 20 million won each to 10 KAIST students every year. The remaining 1 billion won will help invite illustrious scholars to the institute.
Adding to the good news for KAIST, Lee Chong-moon, chairman of the U.S.-based venture company Ambex, has also donated 2 billion won.
The 76-year-old Lee called for the KAIST to inspire a sprit among students by establishing a management center named after him.
2004.05.21 View 15892
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18th Student Council Elected
The KAIST Herald December 3, 2003
The votes were cast and counted on November 27. Donggodongrak won the election of the 18th Undergraduage Student Council of Korea Advanced Institute of Science and Technology (KAIST). Of the 2,340 eligible voters for the 18th student council election, 1,304 votes, or about 56 percent of the total, were amassed after a full day of election on November 27.
The two candidate teams, waiting to hear the result with much anxiety, were juniors Hye-min Kim and Jung-mo Kim running for the president and vice president positions, respectively, of the team "Donggodongrak" and juniors Dong-geun Kim and Yong-jae Yoon running for the same positions, respectively under the name "Woorung Chonggak."
Donggodongrak secured over 58 percent of the votes, with 760 supporting ballots, while Woorung Chongak polled 503 votes, or about 39 percent of the votes. Forty-one votes, or three percent of the votes cast were spoiled votes. With more than half the voters having participated, the election was valid, and Donggodongrak was declared the new student council of KAIST.
The election platform of the Donggodongrak team largely consist of four themes, composed of several smaller goals. First, they assert the "togetherness" of the student government and plan to achieve it by publishing monthly newsletters, hosting an open outdoor student council every other week, and creating various committees.
Secondly, they assert under the theme of an "improving" student government that they will promote festivals and events among the sixteen departments, form an official "class" of the freshmen, and broaden the association of the student representatives.
Third, Donggodongrak declares it wants to create an "open and just environment" by holding periodic meetings with the school for direct discussions of school policies; and by taking care of the welfare of the students in detail.
Finally, they advocate "a student government that communicates with society"; they will support opportunities to become more aware of various issues of society.
President Hye-min Kim, a graduate of Pusan Science High School, has participated in various intramural, socially active groups, and is majoring in applied mathematics. Vice-president Jung-mo Kim is a graduate of Mokpo High School and studies mechanical engineering.
2004.03.15 View 17852
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Researchers Find Mechanism of Tumor Suppressor Genes
By Kim Tae-gyu. Staff ReporterTHE Korea Times 02-06-2004
Korean scientists continue to break new ground in fighting cancer as domestic researchers examined the mechanism of a gene which can help detect and treat various sorts of cancer.
Korea Advanced Institute of Science and Technology (KAIST) Prof. Lim Dae-sik on Thursday said his team uncovered the mechanism of RASSF1A (Ras Association Domain Family 1 A), or tumor suppressor genes, for the first time in the world.
The gene was widely considered to play an important role in reducing the proliferation of cancer cells, but its exact function and processes have remained unknown up to now.
It is the second cancer-related breakthrough by Koreans in a week after Korea Institute of Science and Technology (KIST) Prof. Chung Hesson unveiled the oral anti-cancer drug.
``Cancer results from the failed management of cell cycles due to things like radiation. After a two-year intensive study, we found out how RASSF1A governs the cell cycle,"" Lim said.
Lim added cancer is caused by abnormal cells, which continue to grow and divide out of control unlike normal cells, which die over time. Cancer cells develop into malignant tumors, eventually inflicting damaging effect on the human body.
As a result, a lack of the RASSF1A indicates a high possibility of cancer and injection of it into cells is believed to help cure the deadly disease, according to Lim.
Dr. Song Min-sup, who took charge of the research, said the findings will especially pave the way for the detection and treatment of lung cancer.
``The dearth of RASSF1A was reported mostly in the case of lung cancer. The new findings will provide insight into the diagnosis and cure of lung cancer from its early stages,"" Song explained.
Lung cancer is a very elusive disease because it doesn"t cause symptoms in its infancy. When symptoms do occur, usually it is too late.
``We expect commercial detection kits or drugs for lung cancer in around five years after pre-clinic experimentation and two-phase clinic trials,"" Song expected.
Details of the study is available in the scientific journal Nature Cell Biology in its February edition.
voc200@koreatimes.co.kr
2004.03.15 View 16454
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[Unknown] Wins Program Competition
By Taeg-sang Cho
The KAIST Herald December 3, 2003
The 3rd Korean Collegiate Programming Competition took place on November 7 at Sky-city Convention Center, Seoul. This competition is organized by the Ministry of Telecommunication and is sponsored by KAIST, ACM, and Korean Information Science Institution. This year"s preliminary competition consisted of 112 teams from 50 domestic universities, and 53 teams were selected from the preliminaries. In total, sixty teams, including foreign teams, participated in the main competition that took place at the Sky-city Convention Center.
This year"s competition was won by "Unknown" from KAIST; this team is composed of three students: Min-sang Noh, Gih-moon Song, and Joong-geun Lee. Last year"s competition was also won by a team from KAIST.
In this year"s competition, five teams solved all the problems, but "Unknown" was the best in organizing the programs and in employing various concepts into the program. Another team from KAIST, "KIN~" won 4th Prize.
The winner of this competition automatically becomes an Asian representative at the ACM- International Collegiate Programming Competition (ACM-ICPC) along with the winners of collegiate competitions from Japan, China, India, and Iran. The 28th ACM-ICPC is to be held in March 2004.
2004.03.15 View 19011