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Recombinant E. Coli As a Biofactory for the Biosynthesis of Diverse Nanomaterials
(Distinguished Professor Lee and PhD candidate Choi)
A metabolic research group at KAIST and Chung-Ang University in Korea has developed a recombinant E. coli strain that biosynthesizes 60 different nanomaterials covering 35 elements on the periodic table. Among the elements, the team could biosynthesize 33 novel nanomaterials for the first time, advancing the forward design of nanomaterials through the biosynthesis of various single and multi-elements.
The study analyzed the nanomaterial biosynthesis conditions using a Pourbaix diagram to predict the producibility and crystallinity. Researchers studied a Pourbaix diagram to predict the stable chemical species of each element for nanomaterial biosynthesis at varying levels of reduction potential (Eh) and pH. Based on the Pourbaix diagram analyses, the initial pH of the reaction was changed from 6.5 to 7.5, resulting in the biosynthesis of various crystalline nanomaterials that were previously amorphous or not synthesized.
This strategy was extended to biosynthesize multi-element nanomaterials. Various single and multi-element nanomaterials biosynthesized in this research can potentially serve as new and novel nanomaterials for industrial applications such as catalysts, chemical sensors, biosensors, bioimaging, drug delivery, and cancer therapy.
A research group consisting of PhD candidate Yoojin Choi, Associate Professor Doh Chang Lee, and Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering at KAIST and Associate Professor Tae Jung Park of the Department of Chemistry at Chung-Ang University reported the synthesis. This study, entitled “Recombinant Escherichia coli as a biofactory for various single- and multi-element nanomaterials,” was published online in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) on May 21.
A recent successful biosynthesis of nanomaterials under mild conditions without requiring physical and chemical treatments has triggered the exploration of the full biosynthesis capacity of a biological system for producing a diverse range of nanomaterials as well as for understanding biosynthesis mechanisms for crystalline versus amorphous nanomaterials.
There has been increased interest in synthesizing various nanomaterials that have not yet been synthesized for various applications including semiconducting materials, enhanced solar cells, biomedical materials, and many others. This research reports the construction of a recombinant E. coli strain that co-expresses metallothionein, a metal binding protein, and phytochelatin synthase that synthesizes the metal-binding peptide phytochelatin for the biosynthesis of various nanomaterials. Subsequently, an E. coli strain was engineered to produce a diverse range of nanomaterials, including those never biosynthesized before, by using 35 individual elements from the periodic table and also by combining multi-elements.
Distinguished Professor Lee said, “An environmentally-friendly and sustainable process is of much interest for producing nanomaterials by not only chemical and physical methods but biological synthesis. Moreover, there has been much attention paid to producing diverse and novel nanomaterials for new industrial applications. This is the first report to predict the biosynthesis of various nanomaterials, by far the largest number of various single- and multi-elements nanomaterials. The strategies used for nanomaterial biosynthesis in this research will be useful for further diversifying the portfolio of nanomaterials that can be manufactured.”
Figure: The biosynthesis of diverse nanomaterials using recombinant E. coli. This schematic diagram shows the overall conceptualization of the biosynthesis of various single and multi-element nanomaterials using recombinant E. coli under incubation with corresponding elemental precursors. The 35 elements that were tested to biosynthesize nanomaterials are shown in black circles on the periodic table.
2018.05.23 View 10317 -
New Material for Generating Energy-Efficient Spin Currents
(Professor Byong-Guk Park (left) and Professor Kab-Jin Kim)
Magnetic random access memory (MRAM) is emerging as next-generation memory. It allows information to be kept even without an external power supply and its unique blend of high density and high speed operation is driving global semiconductor manufacturers to develop new versions continuously.
A KAIST team, led by Professor Byong-Guk Park in the Department of Materials Science and Engineering and Professor Kab-Jin Kim in the Department of Physics, recently has developed a new material which enables the efficient generation of a spin current, the core part of operating MRAM. This new material consisting of ferromagnet-transition metal bilayers can randomly control the direction of the generated spin current unlike the existing ones.
They also described a mechanism for spin-current generation at the interface between the bottom ferromagnetic layer and the non-magnetic spacer layer, which gives torques on the top magnetic layer that are consistent with the measured magnetization dependence.
When applying this to spin-orbit torque magnetic memory, it shows the increased efficiency of spin torque and generation of the spin current without an external magnetic field. High-speed operation, the distinct feature of spin-orbit torque-based MRAM that carries its non-volatility, can significantly reduce the standby power better than SRAM.
This new material will expect to speed up the commercialization of MRAM. The research team said that this magnetic memory will further be applied to mobile, wearable, and IoT devices.
This study, conducted in collaboration with Professor Kyung-Jin Lee from Korea University and Dr. Mark Stiles from the National Institute of Standards and Technology in the US, was featured in Nature Materials in March. The research was funded by the Creative Materials Discovery Program of the Ministry of Science and ICT.
(Figure: Ferromagnet-transition metal bilayers which can randomly control the direction of the generated spin current)
2018.05.11 View 8809 -
Yoon Ki Hong Named 2018 Jeong Hun Cho Awardee
(From left: PhD candidate Seungkwan Baek from the Department of Aerospace Engineering, Dr. Yoon Ki Hong from ADD, PhD candidate Wonhee Choi from the School of Mechanical Engineering at Korea University, and Jaehun Lee from Kongju National University High School)
Dr. Yoon Ki Hong from the Agency of Defense Development (ADD) was named the 2018 recipient of the Jong-Hoon Cho Award. The award recognizes outstanding young scientists in the field of aerospace engineering annually. The recipient of this award receives a 25 million KRW prize.
The Award Committee said that Dr. Hong has achieved outstanding work in the field of aerospace engineering. In particular, he conducted research on designing an air heating device which is the crucial component for ground experimental equipment. It is required for testing and evaluating supersonic vehicles’ structural strength tests using technology cannot be imported. In cooperation with his colleagues, he succeeded in developing an air heating device, a feat that has only been accomplished by developed countries. He also verified its operational performance.
Moreover, he received the best paper award from Korean Federation of Science and Minister of Defense Acquisition Program Administration’s Prize.
The award was endowed by the family of the late PhD candidate Jeong Hun Cho, who died in a rocket lab accident in the Department of Aerospace Engineering in 2003. Cho was posthumously conferred an honorary doctorate degree.
In Cho’s memory, his father established the ‘Jeong Hun Cho Award and Scholarship’. Since 2005, the scholarship annually selects three young scholars specializing in aerospace engineering from Cho’s alma maters of KAIST, Korea University, and Kongju National University High School.
In addition to Dr. Hong, the Award Committee chose three students for scholarships: PhD candidate Seungkwan Baek from the Department of Aerospace Engineering, PhD candidate Wonhee Choi from the School of Mechanical Engineering at Korea University, and Jaehun Lee from Kongju National University High School.
2018.05.11 View 8120 -
Park Chosen for Principality of Monaco/ITER Postdoctoral Fellowship
(Jaesun Park in the Integrated Master's and Doctoral Degree Program )
Jaesun Park from the Department of Physics, was selected as a Principality of Monaco/ITER Postdoctoral Fellowship recipient.
This program was established by the Principality of Monaco and an international organization, ITER, in January 2008 to support postdoctoral researchers who will be working for ITER. It is a relatively competitive program because it chooses only five people every two years.
The selected postdoctoral researchers will be working for ITER for two years while conducting research projects with outstanding researchers in the field of nuclear fusion.
ITER, one of the most ambitious energy projects, was launched in 1985 with the purpose of carrying out joint research on nuclear fusion energy. Currently, about 800 people are working for this organization.
Seven ITER member countries (i.e. Korea, the European Union, the United States, China, Japan, Russia, and India) are sharing the expenses and engaging in mega-scale science projects. Korea shares 9.1% (20 billion Euro) of the total construction costs of ITER experimental devices.
Park will begin his duties in early 2019.
2018.05.04 View 7677 -
Cross-Generation Collaborative Labs Open
KAIST opened two cross-generation collaborative labs last month. This novel approach will pair up senior and junior faculty members for sustaining research and academic achievements even after the senior researcher retires.
This is one of the Vision 2031 innovation initiatives established to extend the spectrum of knowledge and research competitiveness. The selected labs will be funded for five years and the funding will be extended if necessary. KAIST will continue to select new labs every year.
A five-member selection committee including the Nobel Laureates Professor Klaus Von Klitzing at the Max-Planck Institute for Solid State Research and Dr. Kurt Wüthrich from ETH Zürich selected the first two labs with senior-junior pairs in March.
(Two renowned scholars' Cross-Generation Collaborative Labs which opened last month.
Distinguished Professor Lee's lab (above) andChair Professor Sung's lab)
Both labs are run by world-renowned scholars: the Systems Metabolic Engineering and Systems Healthcare Laboratory headed by Distinguished Professor Sang-Yup Lee in the Department of Chemical and Biomolecular Engineering and the Acousto-Microfluidics Research Center for Next-Generation Healthcare led by Chair Professor Hyung Jin Sung in the Department of Mechanical Engineering.
Distinguished Professor Lee will be teamed up with Professor Hyun Uk Kim, and their lab aims to mass produce new eco-friendly chemical materials as well as higher-value-added materials which will be used for medicine. The new platform technologies created in the lab are expected to provide information which will benefit human healthcare.
Meanwhile, the Acousto-Microfluidics Research Center for Next-Generation Healthcare will team up with Professors Hyoungsoo Kim and Yeunwoo Cho under Chair Professor Sung. The lab will conduct research on controlling fluids and objects exquisitely on a micro-nano scale by using high-frequency acoustic waves. The lab plans to develop a next-generation healthcare platform for customized diagnoses as well as disease treatment.
KAIST President Sung-Chul Shin, who introduced this novel idea in his research innovation initiative, said that he hopes the Cross-Generation Collaborative Labs will contribute to honoring senior scholars’ research legacies and passing knowledge down to junior researchers in order to further develop their academic achievements. He said, “I sincerely hope the labs will make numerous research breakthroughs in the very near future.”
2018.05.03 View 9906 -
Deep Learning Predicts Drug-Drug and Drug-Food Interactions
A Korean research team from KAIST developed a computational framework, DeepDDI, that accurately predicts and generates 86 types of drug-drug and drug-food interactions as outputs of human-readable sentences, which allows in-depth understanding of the drug-drug and drug-food interactions.
Drug interactions, including drug-drug interactions (DDIs) and drug-food constituent interactions (DFIs), can trigger unexpected pharmacological effects, including adverse drug events (ADEs), with causal mechanisms often unknown. However, current prediction methods do not provide sufficient details beyond the chance of DDI occurrence, or require detailed drug information often unavailable for DDI prediction.
To tackle this problem, Dr. Jae Yong Ryu, Assistant Professor Hyun Uk Kim and Distinguished Professor Sang Yup Lee, all from the Department of Chemical and Biomolecular Engineering at Korea Advanced Institute of Science and Technology (KAIST), developed a computational framework, named DeepDDI, that accurately predicts 86 DDI types for a given drug pair. The research results were published online in Proceedings of the National Academy of Sciences of the United States of America (PNAS) on April 16, 2018, which is entitled “Deep learning improves prediction of drug-drug and drug-food interactions.”
DeepDDI takes structural information and names of two drugs in pair as inputs, and predicts relevant DDI types for the input drug pair. DeepDDI uses deep neural network to predict 86 DDI types with a mean accuracy of 92.4% using the DrugBank gold standard DDI dataset covering 192,284 DDIs contributed by 191,878 drug pairs. Very importantly, DDI types predicted by DeepDDI are generated in the form of human-readable sentences as outputs, which describe changes in pharmacological effects and/or the risk of ADEs as a result of the interaction between two drugs in pair. For example, DeepDDI output sentences describing potential interactions between oxycodone (opioid pain medication) and atazanavir (antiretroviral medication) were generated as follows: “The metabolism of Oxycodone can be decreased when combined with Atazanavir”; and “The risk or severity of adverse effects can be increased when Oxycodone is combined with Atazanavir”. By doing this, DeepDDI can provide more specific information on drug interactions beyond the occurrence chance of DDIs or ADEs typically reported to date.
DeepDDI was first used to predict DDI types of 2,329,561 drug pairs from all possible combinations of 2,159 approved drugs, from which DDI types of 487,632 drug pairs were newly predicted. Also, DeepDDI can be used to suggest which drug or food to avoid during medication in order to minimize the chance of adverse drug events or optimize the drug efficacy. To this end, DeepDDI was used to suggest potential causal mechanisms for the reported ADEs of 9,284 drug pairs, and also predict alternative drug candidates for 62,707 drug pairs having negative health effects to keep only the beneficial effects. Furthermore, DeepDDI was applied to 3,288,157 drug-food constituent pairs (2,159 approved drugs and 1,523 well-characterized food constituents) to predict DFIs. The effects of 256 food constituents on pharmacological effects of interacting drugs and bioactivities of 149 food constituents were also finally predicted. All these prediction results can be useful if an individual is taking medications for a specific (chronic) disease such as hypertension or diabetes mellitus type 2.
Distinguished Professor Sang Yup Lee said, “We have developed a platform technology DeepDDI that will allow precision medicine in the era of Fourth Industrial Revolution. DeepDDI can serve to provide important information on drug prescription and dietary suggestions while taking certain drugs to maximize health benefits and ultimately help maintain a healthy life in this aging society.”
Figure 1. Overall scheme of Deep DDDI and prediction of food constituents that reduce the in vivo concentration of approved drugs
2018.04.18 View 10348 -
KAIST Develops IoT Platform for Food Safety
A research team led by the KAIST Auto-ID Labs developed a GS1 international standard-based IoTs infrastructure platform dubbed Oliot (Open Language of Internet of Things). This platform will be applied to Wanju Local Food, the nation’s largest cooperative, and will be in operation from April 5.
A total of eleven organizations participated in the development of Oliot, with KAIST as the center. This consortium is based on the GS1 international standard-based Oliot platform, which allows collecting and sharing data along the entire process of agrifood from production to processing, distribution, and consumption. It aims at increasing farm incomes and establishing a global ecosystem of domestic agriculture and stockbreeding that provides safe food.
Wanju Local Food is now the world’s first local food co-op with a traceability system from the initial stage of production planning to end sales based on GS1 international standards, which will ensure food safety.
KAIST has been sharing Oliot data in order to apply it to industries around the world. As of April 2018, approximately 900 enterprises and developers from more than 100 countries have downloaded it.
Professor Daeyoung Kim from the School of Computing, who is also Research Director of Auto-ID Labs said, “We are planning to disseminate Oliot to local food cooperatives throughout the nation. We will also cooperate with other countries, like China, Holland, and Hong Kong to create a better ecosystem for the global food industry.
“We are currently collaborating with related business to converge Oliot with AI or blockchain technology that can be applied to various services, such as healthcare and smart factories. Its tangible outcome will be revealed soon,” he added.
Auto-ID Labs are a global research consortium of six academic institutions that research and develop new technologies for advancing global commerce, partnering with GS1 (Global Standard 1), a non-profit organization that established standards for global commerce such as introducing barcodes to the retail industry. The Auto-ID Labs include MIT, University of Cambridge, Keio University, Fudan University, ETH Zurich/University of St. Gallen, and KAIST.
The consortium was supported by the Ministry of Science and ICT as well as the Institute for Information and Communications Technology Promotion for three years from 2015.
The launching of Oliot at Wanju Local Food will be held on April 5.
2018.04.03 View 7880 -
KAIST to Host FinTech Conference 2018
KAIST will be hosting a FinTech Conference with Princeton University (USA), Tsinghua University (China), and EDHEC Business School (France) in Seoul from April 12 to 13 titled State of the Art in Robo-Advising Systems: Financial Technologies for Enhanced Social Security.
The Bendhein Center for Finance and Department of Operations Research and Financial Engineering from Princeton University, Fintech Lab from Tsinghua University, and the Risk Institute from EDHEC will participate as co-hosting organizations in this conference organized by the Department of Industrial & Systems Engineering and the KAIST Center for Wealth Management Technologies.
The conference will discuss issues required for providing customized asset management to the public in terms of theory, technology, and industry.
During the conference, KAIST President Sung-Chul Shin and Chairman and CEO of the National Pension Service Sung Joo Kim will deliver welcoming addresses.
Professor John Mulvey from Princeton University, Professor Michael Dempster from Cambridge University, Professors Wei Xu and Changle Lin from Tsinghua University, Professor Lionel Martellini from EDHEC, and Professor Woo Chang Kim from KAIST are some of the invited speakers at the event.
Moreover, renowned experts in related fields will also participate in the conference, including Founder of Vanguard Group John Bogle, Jin Lee from Ant Financial, Youngsuh Cho from Shinhan Financial Group, Jung-Hwan Lee from Samsung Asset Management, and Hye Young Sung from the National Pension Service Research Institute.
Professor Kim said, “Only a small number of wealthy people can receive life-cycle customized asset management services due to the high cost structure; however, new technology derived from the Fourth Industrial Revolution can reduce the service price in an innovative manner, ultimately leading it to be popularized.”
“In an era with the poverty rate of older people reaching almost 50%.Fintech can enable individuals to manage their assets in an active manner, reinforcing social security without additional social costs in the period,” he added.
These four universities have been hosting the FinTech Conference since 2017. China will host the conference this fall, followed by France next year.
Samsung Asset Management, Alibaba Group, and Ant Financial will sponsor the conference. Anyone interested in this event can find more details at http://wmt.kaist.ac.kr/conference.html.
2018.04.02 View 6820 -
KAIST Welcomes Global Participants to AI World Cup 2018
KAIST will host the AI (Artificial Intelligence) World Cup 2018 in August, and this time it is open to the international community. AI World Cup 2018 will be a very exciting challenge for extending the limit of academic and industrial applications based on AI technology.
KAIST, after launching its AI World Cup 2017 for domestic participants, is now hosting the AI World Cup 2018 for everyone. The AI World Cup will be comprised of three events: 1) Five on five AI Soccer 2) AI Commentator and 3) AI Reporter. Winner of each category, runner-up of AI Soccer, and 2nd runner-up of AI Soccer will receive awards with cash prizes.
For AI Soccer in which AI controlled robots team up to compete, the preliminary rounds will be held in July in a league format, and the final rounds will be played on August 20-22.
For AI Commentator and AI Reporter, eight finalists will be selected for each category based on scoring criteria, and their performance will be evaluated by the judges to select the winner from each category on August 22.
During the final rounds, a variety of events will also take place at KAIST, including tutorial sessions on AI technology, a poster session where students present their research works on AI, not necessarily limited to the scope of AI Soccer, AI Commentator, and AI Reporter, and panel discussions by prominent experts in the field of AI.
Moreover, renowned experts on AI will deliver their keynote addresses. The Cyberbotics CEO Olivier Michel will address his keynote speech on the topic ‘Simulation benchmarks and competitions: a fundamental tool to foster robotics research.’
The AI World Cup was established by the College of Engineering at KAIST to show that AI technology can be further extended to sports, soccer in particular.
Professor Jong-Hwan Kim, the inventor of AI World Cup and chairman of the organizing committee said, “I hope that this event will offer a great chance to develop AI technology for use in the coming years. I wish many people can enjoy the AI World Cup 2018. I would recommend that prospective teams not worry about the technical barrier when deciding whether to participate in the games. Participants from academia and industry can test whether their code runs well in the competition simulator; this way, they will know their level of play and perhaps they can further develop their algorithms.”
“We will also broadcast the final round of AI Soccer online so that people in remote areas can also enjoy watching the games. I am looking forward to seeing all of you at the AI World Cup. Any participant with a passion to prove excellence in AI technology is welcomed with open arms,” he added.
Anyone interested in the AI World Cup 2018 can register online via aiworldcup.org . Registration starts from April 1. The deadline for registration and final code submission is June 30.
(Cubical players in the figure for domestic AI Soccer competition have been replaced with cylindrical players for more agile movements while playing)
(Opening ceremony of AI World Cup 2017)
(Trophy and prize)
(Interview of participant)
(Casters commentating on game playing)
2018.03.30 View 7161 -
Professor Emeritus Jung Ki Park Won the IBA Technology Award 2018
(Professor Emeritus Jung Ki Park)
Professor Emeritus Jung Ki Park from the Department of Chemical and Biomolecular Engineering received the IBA Technology Award from the International Battery Association (IBA).
IBA 2018 was held from March 11 to 16 on Jeju Island, which was the first time it was hosted in Korea. The conference was an excellent opportunity to let the world know the level of the Korean rechargeable battery industry and its technology.
Professor Park delivered his keynote speech titled Advances in Lithium Batteries in Korea at the conference and received the IBA Technology Award as the first Korean recipient.
Professor Park is a world-renowned scholar who was a groundbreaker in the rechargeable battery industry. He was recognized by the IBA Award Committee for his contributions carrying out research and development, fostering competent people, and enhancing the lithium rechargeable battery industry in Korea over the last 30 years.
Professor Park said, “It is my great honor to receive this award, which is the best international award in the field of rechargeable batteries. I would like to share this with my colleagues and students. As competition in the rechargeable industry intensifies, systemic cooperation among industries, academia, and government is needed for the continued development of the battery industry in Korea.
2018.03.19 View 5872 -
The 8th KINC Fusion Research Awardees
The KAIST Institute for NanoCentury held the 8th KINC Fusion Research Award in order to encourage professors’ convergence studies and instill students’ willingness to research. The award ceremony took place in the KI Building at KAIST on March 13.
The KINC Fusion Research Award selects the most outstanding convergence studies among research undertaken last year, and awards researchers who participated in that research.
The 8th KINC Fusion Research Award went to Professor Yoon Sung Nam from the Department of Materials Science and Engineering and Professor Inkyu Park from the Department of Mechanical Engineering. Their research reported the spontaneous self-biomineralization of palladium (Pd) ions on a filamentous virus to form ligand-free Pd nanowires without reducing reagents or using additional surface stabilizers (Title: Virus-Templated Self-Mineralization of Ligand-Free Colloidal Palladium Nanostructures for High Surface Activity and Stability, Advanced Functional Materials (2017)).
Professor Hee-Tae Jung, the Director of KAIST Institute for the NanoCentury and the host of the KINC Fusion Research Award said, “Convergence will be the crucial keyword that will lead to revolutionary change. Hence, the importance of convergence study should be improved. We will put every effort into creating a research environment for increasing convergence study.
The KAIST Institute for the NanoCentury was established in June 2006 under the KAIST Institute with a mission of creating convergence study by tearing down boarders among departments and carrying out interdisciplinary joint research. Currently, approximately 90 professors from 14 departments participate the institute. It aims to become a hub of university institutes for nano-fusion research.
2018.03.19 View 10193 -
MoU Signed by the Republic of Korea Army and KAIST
(From left: KAIST President Sung-Chul Shin and ROKA Chief of Staff Youngwoo Kim)
On March 7, the Republic of Korea Army (ROKA) and KAIST signed an MoU and opened special sessions dedicated to the army in order to reinforce research and development capacities.
The close partnership between KAIST and ROKA will provide an opportunity to establish advanced combat development systems.
Through the MoU, signed by KAIST President Sung-Chul Shin and ROKA Chief of Staff Youngwoo Kim, both organizations will discuss new opportunities for cooperation between academia and military and establish an institute and its curriculum.
KAIST is offering special sessions for the army March 5-9, where about 150 executives from ROKA, including the headquarters, education and training command, and logistics command, will participate.
These session are expected to enhance the army’s capabilities through education on cutting-edge equipment that will emerge during the Fourth Industrial Revolution.
The director of the KAIST Security Convergence Institute, Soo Hyun Kim, said, “KAIST and ROKA will plan and operate various programs together though this partnership as well as special sessions. I hope this cooperation will be an opportunity to enhance the combat development of ROKA.”
2018.03.07 View 5516