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Native-like Spider Silk Produced in Metabolically Engineered Bacterium
Microscopic picture of 285 kilodalton recombinant spider silk fiber
Researchers have long envied spiders’ ability to manufacture silk that is light-weighted while as strong and tough as steel or Kevlar. Indeed, finer than human hair, five times stronger by weight than steel, and three times tougher than the top quality man-made fiber Kevlar, spider dragline silk is an ideal material for numerous applications. Suggested industrial applications have ranged from parachute cords and protective clothing to composite materials in aircrafts. Also, many biomedical applications are envisioned due to its biocompatibility and biodegradability.
Unfortunately, natural dragline silk cannot be conveniently obtained by farming spiders because they are highly territorial and aggressive. To develop a more sustainable process, can scientists mass-produce artificial silk while maintaining the amazing properties of native silk? That is something Sang Yup Lee at the Korea Advanced Institute of Science and Technology (KAIST) in Daejeon, the Republic of Korea, and his collaborators, Professor Young Hwan Park at Seoul National University and Professor David Kaplan at Tufts University, wanted to figure out. Their method is very similar to what spiders essentially do: first, expression of recombinant silk proteins; second, making the soluble silk proteins into water-insoluble fibers through spinning.
For the successful expression of high molecular weight spider silk protein, Professor Lee and his colleagues pieced together the silk gene from chemically synthesized oligonucleotides, and then inserted it into the expression host (in this case, an industrially safe bacterium Escherichia coli which is normally found in our gut). Initially, the bacterium refused to the challenging task of producing high molecular weight spider silk protein due to the unique characteristics of the protein, such as extremely large size, repetitive nature of the protein structure, and biased abundance of a particular amino acid glycine. “To make E. coli synthesize this ultra high molecular weight (as big as 285 kilodalton) spider silk protein having highly repetitive amino acid sequence, we helped E. coli overcome the difficulties by systems metabolic engineering,” says Sang Yup Lee, Distinguished Professor of KAIST, who led this project. His team boosted the pool of glycyl-tRNA, the major building block of spider silk protein synthesis. “We could obtain appreciable expression of the 285 kilodalton spider silk protein, which is the largest recombinant silk protein ever produced in E. coli. That was really incredible.” says Dr. Xia.
But this was only step one. The KAIST team performed high-cell-density cultures for mass production of the recombinant spider silk protein. Then, the team developed a simple, easy to scale-up purification process for the recombinant spider silk protein. The purified spider silk protein could be spun into beautiful silk fiber. To study the mechanical properties of the artificial spider silk, the researchers determined tenacity, elongation, and Young’s modulus, the three critical mechanical parameters that represent a fiber’s strength, extensibility, and stiffness. Importantly, the artificial fiber displayed the tenacity, elongation, and Young’s modulus of 508 MPa, 15%, and 21 GPa, respectively, which are comparable to those of the native spider silk.
“We have offered an overall platform for mass production of native-like spider dragline silk. This platform would enable us to have broader industrial and biomedical applications for spider silk. Moreover, many other silk-like biomaterials such as elastin, collagen, byssus, resilin, and other repetitive proteins have similar features to spider silk protein. Thus, our platform should also be useful for their efficient bio-based production and applications,” concludes Professor Lee.
This work is published on July 26 in the Proceedings of the National Academy of Sciences (PNAS) online.
2010.07.28 View 16722 -
International Center was built to promote greater exchanges and collaborations between the international community and KAIST.
On July 9, 2010, KAIST held an opening ceremony for the construction of International Center. The Center will serve as an internal and external liaison for the university, providing a source of assistance to faculty, administrators, and students on matters related to international activities and initiatives. It will also pursue greater exchanges and collaborations between the international community and KAIST.
The facility accommodates various meetings, exhibitions, library, language services, and other amenities. The International Cooperation Team of KAIST will be moved into this building and provide a variety of services, such as immigration regulations, cultural adjustment, employment, to assist international students, scholars, faculty, and staff at KAIST, as well as Korean students seeking opportunities to study, work, or travel abroad. An international nursery school will also be inside the building so that foreign faculty and students with children can have convenience and quality child care while they are teaching or studying.
At the center will be held many different kinds of international event—one among them is KAIST-ONE, a festival held twice a year in spring and fall to introduce and share culture, education, and food of the global community at KAIST.
2010.07.19 View 10812 -
KAIST held an opening ceremony for the completion of KAIST Institute Building.
A Korean American businessman and his wife, Byiung Jun Park and Chunghi Hong, donated 10 million USD for the construction of the building.
KAIST hosted an opening ceremony on May 11, 2010 for the new addition to its campus, called the Chunghi & Byiung Jun (BJ) Park KAIST Institute Building. The KI Building will serve as a hub for creative multidisciplinary researches.
A Korean American businessman and his wife made a considerable contribution for the construction of the building, worth 10 million USD. KAIST called the building Byiung Jun (BJ) Park and Chunghi Hong in recognition of their contribution. Chairman Park was the founder of the Merchandise Testing Laboratory, a leading textile quality control multinational.
It took 19 months to finish the construction of the KI Building with a total cost of 36 billion Korean won. The building consists of one basement and five ground floors. At the basement, there are clean room and equipment storage room; on the 2nd and 3rd floors, conference and exhibition halls; and on the rest of the floors, research labs and administration offices are to be located.
KAIST’s eight integral research institutes will be placed inside the building: the BioCentury; Information Technology Convergence; Design of Complex Systems; Entertainment Engineering; the NanoCentury; Eco-Energy; Urban Space and Systems; and Optical Science and Technology. Approximately 230 professors from 25 departments of various academic fields will make the KI Building home for study and research. The KI Building will play a great role in producing world-class convergence research works by KAIST researchers and professors, thereby making a contribution to the improvement of national competitiveness.
Vice President of KI Building, Sang-Soo Kim, said, “There has been no such place for us to concentrate research manpower and equipment scattered around the campus. By having all the necessary resources at one place will allow us to conduct convergence researches more efficiently and effectively. I’d like to express my appreciation for the Ministry of Education and Science and Technology as well as Chairman Byiung Jun (BJ) Park, who gave us tremendous supports in the process of constructing the KI Building.”
“The building’s inside has a unique office structure, getting rid of walls or partitions between institutes or departments, to stimulate an environment conducive to convergence researches. We hope to present a new model for creative multidisciplinary researches through a selective and focused approach to be facilitated by institutes at the KI Building,” added by the vice president.
2010.05.20 View 11754 -
A Breakthrough for Cardiac Monitoring: Portable Smart Patch Makes It Possible for Real-time Observation of Heart Movement
Newly invented device makes the monitoring easier and convenient.
Professor Hoi-Jun Yoo of KAIST, Department of Electrical Engineering, said that his research team has invented a smart patch for cardiac monitoring, the first of its kind in the world. Adhesive and can be applied directly to chest in human body, the patch is embedded with a built-in high performance semiconductor integrated circuit (IC), called Healthcare IC, and with twenty five electrodes formed on the patch’s surface.
The 25-electrodes, with a capability of creating various configurations, can detect cardiac contractions and relaxations and collect electrocardiogram (ECG) signals. The Healthcare IC monitors ECG signals and sends the information to a portable data terminal like mobile phones, making it possible for a convenient, easy check up on cardiac observations.
The key technologies used for the patch are the Healthcare IC that measures cardiovascular impedance and ECG signals, and the electronic circuit board made of four layers of fabric, between which electrodes, wireless antenna, circuit board, and flexible battery are installed. With the P-FCB (Planar Fashionable Circuit Board) technology, the research team explained, electrodes and a circuit board are directly stacked into the fabric. Additionally, the Healthcare IC (size: 5mm x 5mm), which has components of electrode control unit, ECG and cardiovascular resistance detection unit, data compression unit, Static Random Access Memory (SRAM), and wireless transmitter receiver, is attached on the fabric. The Healthcare IC is operated by an ultra-low electrical power.
Like a medicated patch commonly used to relieve arthritis pains, the surface of smart patch is adhesive so that people can carry it around without much hassle. A finished product will be 15cm x 15 cm in size and 1mm high in thickness. The Healthcare IC can measure cardiovascular impedance variances with less than 0.81% distortion in 16 different configurations through differential current injectors and reconfigurable high sensitivity detection circuitry.
“The patch will be ideal for patients who suffer a chronic heart disease and need to receive a continuous care for their condition. Once commercialized, the patch will allow the patients to conduct a self-diagnosis at anytime and anywhere,” said Yan Long, a member of the research team.
There has been a continuously growing demand worldwide since 2000 for the development of technology that provides a suitable healthcare management to patients with a chronic heart disease (e.g., cardiovascular problems), but most of the technology developed today are only limited to monitoring electrical signals of heart activity. Cardiovascular monitors, commonly used at many of healthcare places nowadays, are too bulky to use and give uncomfortable feelings to patients when applied. Besides, the current monitors are connected to an electrical line for power supply, and they are unable to have a low power communication with an outdoor communication gadget, thus unavailable for wide use.
Professor Yoo gave his presentation on this new invention at an international conference, International Solid-State Circuits Conference, held on February 8-10 in San Francisco. The subject of his presentation was “A 3.9mW 25-electorde Reconfigurable Thoracic Impedance/ECG SoC with Body-Channel Transponder.”
(Picture 1) Structure of Smart Patch
(Picture 2) Smart patch when applied onto human body
(Picture 3) Data received from smart patch
(Picture 4) Healthcare IC
2010.02.17 View 13716 -
Master of Science in Intellectual Property: First Class Starts on Saturday, February 6, 2010
Newly Established, Postgraduate Course for Master of Science in Intellectual Property
First class starts on February 6th, 2010
In conjunction with Korean Intellectual Property Office (KIPO), KAIST has established a new postgraduate course for a master of science in intellectual property (IP). 41 students have enrolled the course, and its first class will begin February 6th, 2010. With a diverse professional background, the first-year students came from private businesses, IP service industry, and public organizations.
Globally well-known companies—Samsung Electronics, LG Electronics, and the Pohang Iron and Steel Company (POSCO)—and mid-sized companies have offered scholarships to support the new M.S. Program. Business and industry in Korea have recognized the increasingly important role of intellectual property in a modern economy and showed a strong interest in developing workforce specialized in subjects such as, but not limited to, patent law, copyright and designs law, trade mark law, unfair competition, anti-trust law, competition law, and trade secret law.
Prosecutor Chan-Gi Na from Seoul Central District Prosecutor’s Office said, “I’ve applied for the master program at KAIST because I wanted to learn more about intellectual property in greater depth. Through the coursework, I hope to enhance my knowledge on the subjects and use it for the protection of Koreans’ IP related rights and the development of our nation’s IP industry.”
Assistant Manager Jin-Hong Bae from Samsung Securities, Inc. said, “Since the capital market law becomes effective, the need for developing new financial products or services in our finance market has rapidly grown. We no longer can make our financial products by simply copying or ripping off ideas from others. It’s a must practice, not an option, to set up a system under which we are able to protect our IPs.”
“I would like to become an expert in our finance market, who really knows how to commercialize intellectual property assets into benefits, so any know-hows or ideas accumulated from years of working in the field can be registered and protected,” added Mr. Bae.
KAIST’s Mater Program for intellectual property is designed for engineers who wish to acquire the skills required to play a leading role in the field. These engineers, KAIST anticipates, will establish and execute business strategies to protect intellectual property, generate added values for a company, and effectively respond against patent related claims.
The intellectual property will seize up to 90% of business values to be generated in the 21st century. KAIST has long foreseen the need for training top-notch engineers in intellectual property. Combined with multidisciplinary approach to engineering, law, and management, the new M.S. Program will provide students with a variety form of classes to assist them in getting a practical knowledge as needed based on their interests and career aspirations. Examples of the classes are workshops on the change in technology trends—i.e., information technology (IT), environmental technology (ET), and bio technology (BT); standardization of intellectual property and value assessment; and patent law related claims.
“All professors involved in the course are experts who are equipped with hands-on experiences in working on intellectual property for a long time at government agencies, companies, and law firms,” Professor Chul-Ho Kim, responsible for overseeing the entire program, said.
He also expressed his confidence that “We have set up an academic system to induct highly qualified professionals and engineers, capable of handling all aspects of intellectual property related issues, into work places. Our coursework encompasses technology, research and development (R&D), and management, and students who complete the program will be ready to tackle down any intellectual property matters in the 21st century.”
Freshmen convocation for the IP M.S. Program is scheduled on February 20th at KAIST, and President Nam Pyo Suh and Commissioner Jung-Sik Koh of Korean Intellectual Property (KIPO) will attend the event.
2010.02.04 View 12699
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Opening Ceremony Held on February 3, 2010 for Intellectual Property Training Center
KAIST Opened Training Center for Young Entrepreneurs
Commissioner Jung-Sik Koh of Korean Intellectual Property Office (KIPO) and KAIST faculty members including Soon-Hong Jang, Vice President of Operations and Kwang-Hyung Lee, Dean of Academic Affairs Office, joined an opening ceremony held on February 3rd, 2010 to launch a training center for the next generation entrepreneurs who will lead the intellectual property (IP) industry in Korea.
The training center was built in cooperation with KIPO to educate and support young entrepreneurs and prepare them to become tomorrow’s IP business leaders like Bill Gates of Microsoft and Google’s founders, Larry Page and Sergey Brin.
Going through a vigorous selection process, a total of 101 students (51 for intermediate and 50 for advanced level) were chosen last December for an orientation program that will begin February 3rd and continue through February 5th. In addition to the training center at KAIST, KIPO supported to launch another training center at the Pohang University of Science and Technology (POSTECH), which has been up and running since January 27th, 2010.
2010.02.04 View 12505 -
President Nam Pyo Suh of KAIST discussed cooperation with KUSTAR on the training of skilled manpower for research and development (R&D)
Representatives from Korea Advanced Institute of Science and Technology (KAIST), Khalifa University of Science, Technology and Research (KUSTAR), Emirate Nuclear Energy Corporation (ENEC), and the Institute of Applied Technology (IAT) had a meeting on mutual cooperation at the Intercontinental Hotel in Abu Dhabi, the United Arab Emirates (UAE), on January 14, 2009.
Participants of the meeting were President Nam Pyo Suh of KAIST, President Arif Sultan Al Hammadi of KUSTAR, President Mohamed Al Hammadi of ENEC, and Director General Abdullatif Mohamed Al Shamsi of IAT.
A press conference on the training of skilled manpower for research and development (R&D) in the UAE followed afterwards.
At the end of December in 2009, a Korean consortium led by Korea Electric Power Corporation (KEPCO) beat bids from its competitors to construct four nuclear power plants in the UAE. Representing the consortium, Minister Kyung Hwan Choi of Knowledge Economy Ministry signed a comprehensive agreement with KUSTAR and the Institute of Applied Technology (IAT) for the delivery of nuclear power plants.
On his visit, President Suh discussed with KUSTAR the agreement above in greater detail on subjects, where KAIST renders its cooperation, such as research collaboration, university degree program, and training to produce qualified personnel necessary for the development of UAE’s nuclear energy industry.
On research collaboration, sharing its expertise and knowledge accumulated years from the operation of academic and research programs, KAIST agreed to provide cooperation to KUSTAR in developing the latter as a leading science, technology, and research university in ten years through mutual activities such as research collaborations, recruitment and exchange of outstanding researchers and graduate students, expansion of research facilities, and creation of major research policies. Furthermore, in support of nuclear energy program in the UAE, KAIST agreed to develop a joint research program in nuclear engineering and exchange faculty members and students for research collaboration.
On a university degree program, KAIST agreed for mutual cooperation to launch academic programs at KUSTAR, covering BSc, MSc, and PhD degrees to specialize in areas such as mechanical engineering, electrical engineering, nuclear engineering, biomedical engineering, nano technology, science, and information technology. To that end, KAIST will dispatch its faculty to KUSTAR; provide assistance in developing curriculum and teaching materials; and exchange students for research collaboration.
President Arif of KUSTAR mentioned that the university will cooperate with the relevant institutions in Korea, i.e., Korea Development Institute (KDI) and the Korea Institute of Nuclear Safety (KINS), to train skilled workers required for the development of nuclear energy program in the UAE.
He also added, “These cooperative programs will introduce more educational opportunities to our students, and as a result, they can make greater contributions to the development of our nation’s future technologies in various areas. Our students will have a chance to study a broad range of academic subjects through partnership made with the Republic of Korea, and I expect to see improvements in our engineering programs by integrating KAIST’s state-of-the-art academic courses into our system.”
President Arif expressed his hope “to increase cooperation beyond the agreement made between the two countries, like allowing more exchanges and interactions with KAIST for the development of science and technology in Korea and the UAE.”
“Establishing mutual cooperation between KAIST and KUSTAR is a historic event not only for our two universities but also for our two countries. The two universities will make a great contribution to the improvement of the future of humanity by working together to solve the most important, difficult issues faced in the 21st century,” said President Suh.
He also said that “all members of KAIST community will make our utmost efforts to advance the quality of education in two schools and to implement innovative researches through mutual cooperation.”
KUSTAR, a national university in the UAE, was founded on February 13, 2007 by a mandate of the current President Shaikh Khalifa Bin Zayed Al Nahyan to create a higher education institute.
KUSTAR has been building its permanent campus in Abu Dhabi, the capital of UAE since establishment and merged with the campus in Sharjah (formerly known as Etisalat University College with 18 years of history) in 2008. The University offers education and research programs in five disciplines of engineering, logistics and management, health science, homeland security, and applied science.
There are more or less 30 foreign accredited universities set up in the UAE from countries like the US, UK, Australia, France, Ireland, and Canada. Examples of such, among other things, are New York University Abu Dhabi campus and Middlesex University Dubai campus.
Many of the foreign universities in the UAE, however, have colleges of pharmacy, computer science, aviation, management information, fashion design, business management, and medical science including Harvard Medical School Dubai Center, but not many in science and research. Therefore, KAIST’s assistance in KUSTAR’s endeavor to become a leading science and research university in the UAE is timely. The current government of UAE anticipates, with a great interest, to see a leading science and research intuition built in their nation.
Attachment: Current Status of Universities in the UAE as of 2009
Background Information
The United Arab Emirates (UAE) is a federation of seven emirates (Abu Dhabi, Dubai, Sharjah, Ajman, Umm al-Quwain, Ras al-Khaimah, and Fujairah) situated on the Arabian Peninsula, which borders with Oman and Saudi Arabia.
The UAE has the world"s sixth largest oil reserves. As of 2008, its gross domestic product is $2,621,000.5 million and its nominal per capita gross domestic product is $5 5,028, becoming one of the most developed economies in the Middle East. The UAE’s total population as of the said year is 4,760.4 thousand, and its purchasing power per capita is 40th largest in the world. The UAE’s Human Development Index for Asian continent is relatively high, ranking 31st globally.
In 1985, the UAE launched its own airline, Emirates Airline, which has become one of the fastest growing airlines in the world. The Emirates Airline is a sponsor for Arsenal soccer club.
The Republic of Korea established full diplomatic relations with the UAE in June of 1980. On December 27, 2009, a Korean consortium led by Korea Electrical Power Corporation (KEPCO) signed a contract with the UAE to build nuclear power plants.
2010.01.15 View 15093 -
KAIST to Host ITTP Conference in Tunisia
KAIST"s Global IT Technology Program (ITTP) will host an international conference at Hammamet Hotel in Tunisia in cooperation with its counterpart at Seoul National University (SNU) on Nov. 23, university authorities said on Wednesday (Nov. 18).
The event is a pre-conference for the ICT4All Forum on Nov. 24-25 which the Tunisian government is organizing with the ADB, World Bank, Arab Society for Intellectual Property and the UTICA to deal with developing information and communication technologies.
KAIST"s ITTP which started in 2006 is designed to build global network of IT leaders around the world. The program supported by the Korean Ministry of Knowledge and Economy offers a customized master"s and doctoral degree program for foreign government officials, employees of public institutions and senior researchers at national research centers working in the IT fields. Scholarships are provided for all trainees, for up to 2 years for master"s students and up to 3 years for doctoral students.
The program focuses on transferring advanced technologies and business strategies of Korea to the global IT leaders of the next generation.
During the conference, seven government officials from as many countries currently under the KAIST or SNU programs will present international cooperation cases based on their own experiences in the IT fields. KAIST ITTP organizers will also provide an educational session on the mobile government for Tunisian experts and conference participants in the information and communications fields.
2009.11.20 View 12746
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KAIST Ranked 21st among World's Engineering Universities
KAIST was placed 21st in the area of engineering and information technology in this year"s world university rankings released on Oct. 8 (Thursday), climbing 13 notches from last year"s 34th. Seoul National University (SNU) ranked 27th, which made KAIST and SNU the only two institutions making it to the top 50 list. POSTECH ascended to 81st from last year"s 143rd.
In the "Times Higher Education--QS World University Rankings," Korean universities showed remarkable advancement this year; all-told five Korean universities made it to the top 200 list, as Yonsei and Korea universities were included in the list for the first time.
In overall rankings, KAIST moved 26 notches upward to grab the 69th position in the list, while SNU was placed 47th (50th last year).
The list, compiled by The Times (of London) newspaper annually, is topped by Harvard University, followed by University of Cambridge and Yale University.
Again this year, the United States had most of the top 100 universities in the world, with 32 included in the list. It was followed by the United Kingdom (18), Australia (8) and Japan (6).
Now in their 6th edition, the Times Higher Education--QS World University Rankings received a record level of responses from both the academic community and employers in 2009. A total of 9,386 academics (or 47 percent over 6,354 in 2008) and 3,281 employers (compared to 2,339 in 2008) responded to the surveys.
Times Higher Education -- QS World University Rankings evaluates institutions worldwide in four main categories: quality of research, globalization, quality of education, and contributions of graduates to society. The evaluation also considers academic peer review, citations per faculty, recruiter review, international faculty, international students and faculty-student ratio.
2009.10.09 View 12940
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KAIST Secures Top Ranking of Korean Universities
KAIST won the No. 1 position for the second year in a row in the daily JoongAng Ilbo"s university rankings for 2009. Seoul National University took back the No. 2 spot, followed in order by POSTECH, Korea and Yonsei universities.
The survey was conducted in the four categories, educational environment/finance, professors" research, general reputation/social advancement and globalization. KAIST scored 293 points out of possible 400 this year, while the second-ranking SNU and third-ranking POSTECH earned 234 and 226 points, respectively.
The daily noted that KAIST particularly excelled in the category of educational environment/finance. It observed that donations to KAIST surged almost 100 times for the past three years since 2006 when President Suh took office.
In specific rankings of universities by academic disciplines, SNU came in first overall. KAIST topped in the science and engineering field, while Korea University ranked first in liberal arts studies.
This year, 88 four-year universities participated in the survey. The daily JoongAng Ilbo started its annual evaluation of Koran universities in 1994 to stimulate productive competition among institutions of higher learning and to provide objective standards for students and their parents to select schools for application.
For more information, news.joins.com/article/391/3789391.html
2009.09.24 View 13623
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Scaling Laws between Population and Facility Densities Found
A research team led by Prof. Ha-Woong Jeong of the Department of Physics, KAIST, has found a positive correlation between facilities and population densities, university authorities said on Tuesday (Sept. 2). The research was conducted in the cooperation with a research team of Prof. Beom-Jun Kim at Sungkyunkwan University.
The researchers investigated the ideal relation between the population and the facilities within the framework of an economic mechanism governing microdynamics.
In previous studies based on the global optimization of facility positions in minimizing the overall travel distance between people and facilities, the relation between population and facilities should follow a simple law. The new empirical analysis, however, determined that the law is not a fixed value but spreads in a broad range depending on facility types.
To explain this discrepancy, the researchers proposed a model based on economic mechanism that mimics the competitive balance between the profit of the facilities and the social opportunity cost for population.
The results were published in the Proceedings of the National Academy of Sciences of the United States on Aug. 25.
2009.09.04 View 11956
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Transparent Antenna for Automobile Developed
A research team led by Prof. Jae-Woo Park of the School of Electrical Engineering & Computer Science, KAIST, developed a transparent antenna for the next-generation automobiles, university authorities said on Monday (Aug. 17).
The development was made possible through joint researches with the Hyundai-Kia Automotive Group; Winncom, a car antenna manufacturer; and a group of researchers led by Han-Ki Kim of the Department of Display Materials Engineering at Kyung Hee University in Seoul.
The transparent antennas were developed in two kinds -- one for the HSDPA (High-Speed Downlink Packet Access), a new protocol for mobile telephone data transmission, and the other for transmitting and receiving radio wave for emergency call.
Using the transparent electrically conductive film formation technology, the transparent antennas are to be mounted on the windshield of a vehicle.
"The development of transparent antenna represents a step forward for the advancement of the next-generation automotive electronic technology," said Seong-woo Kim, a senior researcher at the Hyundai-Kia Group.
2009.08.18 View 12347