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Autophagy in Dendritic Cells Helps Anticancer Activity
Autophagy contributes to the homeostasis of a cell and recently another function of autophagy has been reported. A KAIST research team found that the autophagy of dendritic cells supports T-cell anticancer activity.
Autophagy is a process of maintaining cell homeostasis by removing cellular waste and damaged cellular organelles; nevertheless, its role in the presentation of phagocytized tumor-associated antigens remains vague.
Meanwhile, dendritic cells are the ones that recognize pathogens or cancer antigens, and induce immune responses in T cells. When cancer cells are killed by radiation or an anticancer drug, dendritic cells absorb and remove them and present antigens on their surface to transfer them to T-cells.
Professor Heung Kyu Lee from the Graduate School of Medical Science and Engineering and his team found that the autophagy of dendritic cells plays a key role in T-cell activation and they proposed the principles of enhancing anti-cancer effects.
Their experiments showed that T-cell activation of dendritic cells as well as anticancer immune response dropped when there is a deficiency of Atg5 (autophagy-related) in dendritic cells.
Interestingly, Atg5-deficient dendritic cells significantly elevated receptor CD36 on the surface of the cells, which increased the phagocytosis of apoptotic tumor cells yet restricted the activation of T-cells.
At this time, when introducing antibodies into the system in order to block the receptor CD36, the anti-tumor T-cell response increased substantially while tumor growth declined.
Professor Lee said, “This study allowed us to explore the role of autophagy in the anti-cancer immune response of T-cells. We look forward to developing targeted anti-cancer therapies using the receptor CD36.”
This research was published in Autophagy (10.1080/15548627.2019.1596493) on March 22, 2019.
Figure 1.Mechanism of autophagy in dendritic cells
Figure 2. A role of autophagy in dendritic cells
2019.05.13 View 49962 -
KAIST Identifies the Cause of Sepsis-induced Lung Injury
(Professor Pilhan Kim from the Graduate School of Medical Science and Engineering)
A KAIST research team succeeded in visualizing pulmonary microcirculation and circulating cells in vivo with a custom-built 3D intravital lung microscopic imaging system. They found a type of leukocyte called neutrophils aggregate inside the capillaries during sepsis-induced acute lung injury (ALI), leading to disturbances and dead space in blood microcirculation.
According to the researchers, this phenomenon is responsible for tissue hypoxia causing lung damage in the sepsis model, and mitigating neutrophils improves microcirculation as well as hypoxia.
The lungs are responsible for exchanging oxygen with carbon dioxide gases during the breathing process, providing an essential function for sustaining life. This gas exchange occurs in the alveoli, each surrounded by many capillaries containing the circulating red blood cells.
Researchers have been making efforts to observe microcirculation in alveoli, but it has been technically challenging to capture high-resolution images of capillaries and red blood cells inside the lungs that are in constant breathing motion.
Professor Pilhan Kim from the Graduate School of Medical Science and Engineering and his team developed an ultra-fast laser scanning confocal microscope and an imaging chamber that could minimize the movement of a lung while preserving its respiratory state. They used this technology to successfully capture red blood cell circulation inside the capillaries of animal models with sepsis.
During the process, they found that hypoxia was induced by the increase of dead space inside the lungs of a sepsis model, a space where red blood cells do not circulate. This phenomenon is due to the neutrophils aggregating and trapping inside the capillaries and the arterioles. It was also shown that trapped neutrophils damage the lung tissue in the sepsis model by inhibiting microcirculation as well as releasing reactive oxygen species.
Further studies showed that the aggregated neutrophils inside pulmonary vessels exhibit a higher expression of the Mac-1 receptor (CD11b/CD18), which is a receptor involved in intercellular adhesion, compared to the neutrophils that normally circulate. Additionally, they confirmed that Mac-1 inhibitors can improve inhibited microcirculation, ameliorate hypoxia, while reducing pulmonary edema in the sepsis model.
Their high-resolution 3D intravital microscope technology allows the real-time imaging of living cells inside the lungs. This work is expected to be used in research on various lung diseases, including sepsis.
The research team’s pulmonary circulation imaging and precise analytical techniques will be used as the base technology for developing new diagnostic technologies, evaluating new therapeutic agents for various diseases related to microcirculation.
Professor Kim said, “In the ALI model, the inhibition of pulmonary microcirculation occurs due to neutrophils. By controlling this effect and improving microcirculation, it is possible to eliminate hypoxia and pulmonary edema – a new, effective strategy for treating patients with sepsis.”
Their 3D intravital microscope technology was commercialized through IVIM Technology, Inc., which is a faculty startup at KAIST. They released an all-in-one intravital microscope model called ‘IVM-CM’ and ‘IVM-C’. This next-generation imaging equipment for basic biomedical research on the complex pathophysiology of various human diseases will play a crucial role in the future global bio-health market.
This research, led by Dr. Inwon Park from the Department of Emergency Medicine at Seoul National University Bundang Hospital and formally the Graduate School of Medical Science and Engineering at KAIST, was published in the European Respiratory Journal (2019, 53:1800736) on March 28, 2019.
Figure 1. Custom-built high-speed real-time intravital microscope platform
Figure 2. Illustrative schematic and photo of a 3D intravital lung microscopic imaging system
Figure 3. Aggregation of neutrophils and consequent flow disturbance in pulmonary arteriole in sepsis-induced lung injury
2019.05.07 View 43500 -
Professor Ji-Hyun Lee Awarded the Sasada Prize
Professor Ji-Hyun Lee from the Graduate School of Culture Technology was awarded the Sasada Prize during the 24th annual Conference of Computer-Aided Architectural Design Research in Asia (CAADRIA) held in Wellington, New Zealand on April 15.
The Sasada Award honors the late Professor Tsuyoshi Sasada (1941-2005), the former Professor of Osaka University and co-founder and fellow of CAADRIA. It is given to an individual who has contributed to the next generation of researchers and academics, to the wider profession and practice in computer-aided design and research, and has earned recognition in the academic community.
Professor Lee was recognized for her development of CAAD (Computer-Aided Architectural Design) through her research work on the land price precision system using case-based reasoning. Her research team proposed a model for estimating the average apartment price in an administrative district after collecting 40 variables from the six major Korean cities, excluding Seoul and Ulsan. Their follow-up studies showed the possibility of replacing existing experts’ predictions.
Professor Lee has been steadily researching for 20 years on case-based reasoning (CBR), a field of artificial intelligence, and has published more than 40 papers in the field of CBR. Meanwhile, the CAAD Future 2019 event will be held at KAIST in June.
2019.04.23 View 5461 -
True-meaning Wearable Displays: Self-powered, Washable and Wearable
(Video: The washing process of wearing display module) When we think about clothes, they are usually formed with textiles and have to be both wearable and washable for daily use; however, smart clothing has had a problem with its power sources and moisture permeability, which causes the devices to malfunction. This problem has now been overcome by a KAIST research team, who developed a textile-based wearable display module technology that is washable and does not require an external power source.
To ease out the problem of external power sources and enhance the practicability of wearable displays, Professor Kyung Cheol Choi from the School of Electrical Engineering and his team fabricated their wearing display modules on real textiles that integrated polymer solar cells (PSCs) with organic light emitting diodes (OLEDs).
PSCs have been one of the most promising candidates for a next-generation power source, especially for wearable and optoelectronic applications because they can provide stable power without an external power source, while OLEDs can be driven with milliwatts. However, the problem was that they are both very vulnerable to external moisture and oxygen. The encapsulation barrier is essential for their reliability. The conventional encapsulation barrier is sufficient for normal environments; however, it loses its characteristics in aqueous environments, such as water. It limits the commercialization of wearing displays that must operate even on rainy days or after washing.
To tackle this issue, the team employed a washable encapsulation barrier that can protect the device without losing its characteristics after washing through atomic layer deposition (ALD) and spin coating. With this encapsulation technology, the team confirmed that textile-based wearing display modules including PSCs, OLEDs, and the proposed encapsulation barrier exhibited little change in characteristics even after 20 washings with 10-minute cycles. Moreover, the encapsulated device operated stably with a low curvature radius of 3mm and boasted high reliability.
Finally, it exhibited no deterioration in properties over 30 days even after being subjected to both bending stress and washing. Since it uses a less stressful textile, compared to conventional wearable electronic devices that use traditional plastic substrates, this technology can accelerate the commercialization of wearing electronic devices. Importantly, this wearable electronic device in daily life can save energy through a self-powered system.
Professor Choi said, “I could say that this research realized a truly washable wearable electronic module in the sense that it uses daily wearable textiles instead of the plastic used in conventional wearable electronic devices. Saving energy with PSCs, it can be self-powered, using nature-friendly solar energy, and washed. I believe that it has paved the way for a ‘true-meaning wearable display’ that can be formed on textile, beyond the attachable form of wearable technology.”
This research, in collaboration with Professor Seok Ho Cho from Chonnam National University and led by Eun Gyo Jeong, was published in Energy and Environmental Science (10.1039/c8ee03271h) on January 18, 2019.
Figure 1. Schematic and photo of a washable wearing display module
Figure 2. Cover page of Energy and Environmental Science
2019.03.21 View 30304 -
Blue-enriched White Light to Wake You Up in the Morning
(from left: Professor Hyun Jung Chung, Professor Hyeon-Jeong Suk, Taesu Kim and Professor Kyungah Choi)
Here is a good news for those of who have difficulty with morning alertness. A KAIST research team proposed that a blue-enriched LED light can effectively help people overcome morning drowsiness. This study will provide the basis for major changes in future lighting strategies and thereby help create better indoor environments.
Considerable research has been devoted to unmasking circadian rhythms. The 2017 Nobel Prize in Physiology or Medicine went to Jeffrey C. Hall, Michael Rosbash, and Michael W. Young for unveiling the molecular mechanisms that control circadian rhythms. In particular, the relationship between light and its physiological effects has been investigated since the discovery of a novel, third type of photoreceptor in the human retina in the early 2000s. Rods and cones regulate visual effects, while the third type, photosensitive retinal ganglion cells, regulate a large variety of biological and behavioral processes including melatonin and cortisol secretion, alertness, and functional magnetic resonance imaging (fMRI).
Initial studies on light sources have shown that blue monochromatic, fully saturated lights are effective for stimulating physiological responses, but the relative effectiveness of commercially available white light sources is less well understood. Moreover, the research was more focused on the negative effects of blue light; for instance, when people are exposed to blue light at night, they have trouble achieving deep sleep because the light restrains melatonin secretion.
However, Professor Hyeon-Jeong Suk and Professor Kyungah Choi from the Department of Industrial Design and their team argue that the effects of blue-enriched morning light on physiological responses are time dependent, and that it has positive effects on melatonin levels and the subjective perception of alertness, mood, and visual comfort compared with warm white light.
The team conducted an experiment with 15 university students. They investigated whether an hour of morning light exposure with different chromaticity would affect their physiological and subjective responses differently. The decline of melatonin levels was significantly greater after the exposure to blue-enriched white light in comparison with warm white light.
Professor Suk said, “Light takes a huge part of our lives since we spend most of our time indoors. Light is one of the most powerful tools to affect changes in how we perceive and experience the environment around us.”
Professor Choi added, “When we investigate all of the psychological and physiological effects of light, we see there is much more to light than just efficient quantities. I believe that human-centric lighting strategies could be applied to a variety of environments, including residential areas, learning environments, and working spaces to improve our everyday lives.”
This research was collaborated with Professor Hyun Jung Chung from the Graduate School of Nanoscience and Technology and was published in Scientific Reports (10.1038/s41598-018-36791-5) on January 23, 2019.
Figure 1. Changes in melatonin secretion during day and night time
2019.03.06 View 10538 -
KAIST Develops Analog Memristive Synapses for Neuromorphic Chips
(Professor Sung-Yool Choi from the School of Electrical Engineering)
A KAIST research team developed a technology that makes a transition of the operation mode of flexible memristors to synaptic analog switching by reducing the size of the formed filament. Through this technology, memristors can extend their role to memristive synapses for neuromorphic chips, which will lead to developing soft neuromorphic intelligent systems.
Brain-inspired neuromorphic chips have been gaining a great deal of attention for reducing the power consumption and integrating data processing, compared to conventional semiconductor chips. Similarly, memristors are known to be the most suitable candidate for making a crossbar array which is the most efficient architecture for realizing hardware-based artificial neural network (ANN) inside a neuromorphic chip.
A hardware-based ANN consists of a neuron circuit and synapse elements, the connecting pieces. In the neuromorphic system, the synaptic weight, which represents the connection strength between neurons, should be stored and updated as the type of analog data at each synapse.
However, most memristors have digital characteristics suitable for nonvolatile memory. These characteristics put a limitation on the analog operation of the memristors, which makes it difficult to apply them to synaptic devices.
Professor Sung-Yool Choi from the School of Electrical Engineering and his team fabricated a flexible polymer memristor on a plastic substrate, and found that changing the size of the conductive metal filaments formed inside the device on the scale of metal atoms can make a transition of the memristor behavior from digital to analog.
Using this phenomenon, the team developed flexible memristor-based electronic synapses, which can continuously and linearly update synaptic weight, and operate under mechanical deformations such as bending.
The team confirmed that the ANN based on these memristor synapses can effectively classify person’s facial images even when they were damaged. This research demonstrated the possibility of a neuromorphic chip that can efficiently recognize faces, numbers, and objects.
Professor Choi said, “We found the principles underlying the transition from digital to analog operation of the memristors. I believe that this research paves the way for applying various memristors to either digital memory or electronic synapses, and will accelerate the development of a high-performing neuromorphic chip.”
In a joint research project with Professor Sung Gap Im (KAIST) and Professor V. P. Dravid (Northwestern University), this study was led by Dr. Byung Chul Jang (Samsung Electronics), Dr. Sungkyu Kim (Northwestern University) and Dr. Sang Yoon Yang (KAIST), and was published online in Nano Letters (10.1021/acs.nanolett.8b04023) on January 4, 2019.
Figure 1. a) Schematic illustration of a flexible pV3D3 memristor-based electronic synapse array. b) Cross-sectional TEM image of the flexible pV3D3 memristor
2019.02.28 View 7856 -
Kimchi Toolkit by Costa Rican Summa Cum Laude Helps Make the Best Flavor
(Maria Jose Reyes Castro with her kimchi toolkit application)
Every graduate feels a special attachment to their school, but for Maria Jose Reyes Castro who graduated summa cum laude in the Department of Industrial Design this year, KAIST will be remembered for more than just academics. She appreciates KAIST for not only giving her great professional opportunities, but also helping her find the love of her life.
During her master’s course, she completed an electronic kimchi toolkit, which optimizes kimchi’s flavor. Her kit uses a mobile application and smart sensor to find the fermentation level of kimchi by measuring its pH level, which is closely related to its fermentation. A user can set a desired fermentation level or salinity on the mobile application, and it provides the best date to serve it.
Under the guidance of Professor Daniel Saakes, she conducted research on developing a kimchi toolkit for beginners (Qualified Kimchi: Improving the experience of inexperienced kimchi makers by developing a monitoring toolkit for kimchi).
“I’ve seen many foreigners saying it’s quite difficult to make kimchi. So I chose to study kimchi to help people, especially those who are first-experienced making kimchi more easily,” she said. She got recipes from YouTube and studied fermentation through academic journals. She also asked kimchi experts to have a more profound understanding of it.
Extending her studies, she now works for a startup specializing in smart farms after starting last month. She conducts research on biology and applies it to designs that can be used practically in daily life.
Her tie with KAIST goes back to 2011 when she attended an international science camp in Germany. She met Sunghan Ro (’19 PhD in Nanoscience and Technology), a student from KAIST and now her husband. He recommended for her to enroll at KAIST because the school offers an outstanding education and research infrastructure along with support for foreign students.
At that time, Castro had just begun her first semester in electrical engineering at the University of Costa Rica, but she decided to apply to KAIST and seek a better opportunity in a new environment. One year later, she began her fresh start at KAIST in the fall semester of 2012.
Instead of choosing her original major, electrical engineering, she decided to pursue her studies in the Department of Industrial Design, because it is an interdisciplinary field where students get to study design while learning business models and making prototypes.
She said, “I felt encouraged by my professors and colleagues in my department to be creative and follow my passion. I never regret entering this major.”
When Castro was pursuing her master’s program in the same department, she became interested in interaction designs with food and biological designs by Professor Saakes, who is her advisor specializing in these areas.
After years of following her passion in design, she now graduates with academic honors in her department.
It is a bittersweet moment to close her journey at KAIST, but “I want to thank KAIST for the opportunity to change my life for the better. I also thank my parents for being supportive and encouraging me. I really appreciate the professors from the Department of Industrial Design who guided and shaped who I am,” she said.
Figure 1. The concept of the kimchi toolkit
Figure 2. The scenario of the kimchi toolkit
2019.02.19 View 4524 -
KAIST Earns AACSB Business School Accreditation
The KAIST College of Business re-earned business school accreditation from the Association to Advance Collegiate Schools of Business (AACSB) International. The school first earned the accreditation in 2003, and has continued to receive the accreditation four consecutive times. Currently only 5% of the 16,000 business schools around the world have earned AACSB accreditation. KAIST received a good evaluation for the competitive research of its faculty, its executive education programs based on strong industry-academia ties, and specialized MBA and master’s program, which includes programs such as social entrepreneurship and green business and policy.Alexander Triantis, dean of the Robert H. Smith School of Business at the University of Maryland and a judge for AACSB Accreditation said, “I was impressed to see students from KAIST have a high standard of knowledge. A number of its graduates continue to be appointed as professors of top universities abroad, which shows its strong global competence”. AACSB was founded in 1916 by deans of business colleges from prestigious universities such as Harvard University, Stanford University and Columbia University, to provide business and accounting accreditation to universities. Evaluation for AACSB accreditation takes place every five years. Schools are evaluated based on fifteen standards, including student admission and graduation requirements, student-faculty ratios, faculty’s intellectual contributions, research infrastructure, global cooperation, and industry-academia programs. They can be eligible for re-accreditation if they satisfy the conditions offered by AACSB International and are committed to continuous improvement every five years. KAIST also earned the accreditation from the European Foundation for Management Development Quality Improvement System (EQUIS) three consecutive times since 2010. In 2013, it earned membership into the Partnership in International Management (PIM). Membership is only possible for those who have AACSB and EQUIS accreditation and they can be listed as a candidate school through voting. The candidate schools can finally earn membership after one year of strict screening. As of January 2019, there are 65 prestigious graduate schools of business, including KAIST, listed as PIM members.
2019.02.01 View 4937 -
Stretchable Multi-functional Fiber for Energy Harvesting and Strain Sensing
(from left: Professor Steve Park, Jeongjae Ryu and Professor Seungbum Hong)
Fiber-based electronics are expected to play a vital role in next-generation wearable electronics. Woven into textiles, they can provide higher durability, comfort, and integrated multi-functionality. A KAIST team has developed a stretchable multi-functional fiber (SMF) that can harvest energy and detect strain, which can be applied to future wearable electronics.
With wearable electronics, health and physical conditions can be assessed by analyzing biological signals from the human body, such as pulse and muscle movements. Fibers are highly suitable for future wearable electronics because they can be easily integrated into textiles, which are designed to be conformable to curvilinear surfaces and comfortable to wear. Moreover, their weave structures offer support that makes them resistant to fatigue. Many research groups have developed fiber-based strain sensors to sense external biological signals. However, their sensitivities were relatively low.
The applicability of wearable devices is currently limited by their power source, as the size, weight, and lifetime of the battery lessens their versatility. Harvesting mechanical energy from the human body is a promising solution to overcome such limitations by utilizing various types of motions like bending, stretching, and pressing. However, previously reported, fiber-based energy harvesters were not stretchable and could not fully harvest the available mechanical energy.
Professor Seungbum Hong and Professor Steve Park from the Department of Materials Science and Engineering and their team fabricated a stretchable fiber by using a ferroelectric layer composed of P(VDF-TrFE)/PDMS sandwiched between stretchable electrodes composed of a composite of multi-walled carbon nanotubes (MWCNT) and poly 3,4-ethylenedioxythiophene polystyrenesulfonate (PEDOT:PSS).
Cracks formed in MWCNT/PEDOT:PSS layer help the fiber show high sensitivity compared to the previously reported fiber strain sensors. Furthermore, the new fiber can harvest mechanical energy under various mechanical stimuli such as stretching, tapping, and injecting water into the fiber using the piezoelectric effect of the P(VDF-TrFE)/PDMS layer.
Professor Hong said, “This new fiber has various functionalities and makes the device simple and compact. It is a core technology for developing wearable devices with energy harvesting and strain sensing capabilities.”
This article, led by PhD candidate Jeongjae Ryu, was published in the January 2019 issue of Nano Energy.
Figure 1.Schematic illustration of an SMF fiber and its piezoelectric voltage output and response to strain.
Figure 2. Photographs of a stretchable multi-functional fiber being stretched by 100%, bent, and twisted.
2019.01.31 View 7532 -
First Korean Member of OceanObs' Organizing Committee
Professor Sung Yong Kim from the Department of Mechanical Engineering became the first Korean to be elected as an organizing committee member of the international conference OceanObs’19’, specializing in the ocean observing field.
Professor Kim has been actively engaged in advisory panels, technical committees, and working groups for the North Pacific Marine Science Organization (PICES). Through numerous activities, he was recognized for his professionalism and academic achievements, which led him to be appointed as a member of the organizing committee.
The organizing committee is comprised of leading scholars and researchers from 20 countries, and Professor Kim will be the first Korean scientist to participate on the committee.
Since 1999, the conference has been held every decade. Global experts specializing in oceanic observation gather to discuss research directions for the next ten years by monitoring physical, biological, and chemical variables in regional, national, and global oceans and applying marine engineering.
This year, approximately 20 institutes including NASA’s Jet Propulsion Laboratory (JPL), the National Science Foundation, the National Oceanic and Atmospheric Administration, and the European Space Agency will support funds as well as high-tech equipment to the conference.
This year’s conference theme is the governance of global ocean observing systems such as underwater gliders, unmanned vehicles, remote sensing, and observatories. The conference will hold discussions on monitoring technology and information systems to ensure human safety as well as to develop and preserve food resources. Additionally, participants will explore ways to expand observational infrastructures and carry out multidisciplinary approaches.
There will also be collaborations with the Global Ocean Observing System (GOOS) and the Partnership for Observation of the Global Oceans (POGO) to organize ocean observing programs and discuss priorities.
Finally, they will set a long-term plan for solving major scientific issues, such as climate change, ocean acidification, energy, and marine pollution.
Professor Kim said, “Based on the outcomes drawn from the conference, I will carry out research on natural disasters and climate change monitoring by using unmanned observing systems. I will also encourage more multidisciplinary research in this field.”
2019.01.25 View 9060 -
Enhanced Video Quality despite Poor Network Conditions
(from left: Jaehong Kim, Youngmok Jung, Hyunho Yeo, Professor Dongsu Han and Professor Jinwoo Shin)
Professor Jinwoo Shin and Professor Dongsu Han from the School of Electrical Engineering developed neural adaptive content-aware internet video delivery. This technology is a novel method that combines adaptive streaming over HTTP, the video transmission system adopted by YouTube and Netflix, with a deep learning model.
This technology is expected to create an internet environment where users can enjoy watching 4K and AV/VR videos with high-quality and high-definition (HD) videos even with weak internet connections.
Thanks to video streaming services, internet video has experienced remarkable growth; nevertheless, users often suffer from low video quality due to unfavorable network conditions. Currently, existing adaptive streaming systems adjust the quality of the video in real time, accommodating the continuously changing internet bandwidth. Various algorithms are being researched for adaptive streaming systems, but there is an inherent limitation; that is, high-quality videos cannot be streamed in poor network environments regardless of which algorithm is used.
By incorporating super-resolution in adaptive streaming, the team overcame the limit of existing content distribution networks, of which their quality relies too much on the bandwidth. In the conventional method, the server that provides the video splits a video into certain lengths of time in advance. But the novel system introduced by the team allows the downloading of neural network segments. To facilitate this method, the video server needs to provide deep neural networks for each video segment as well as sizes of Deep Neural Networks (DNN) according to the specifications of the user’s computing capacity.
The largest neural network size is two megabytes, which is considerably smaller than video. When downloading the neural network from the user’s video player, it is split into several segments. Even its partial download is sufficient for a slightly comprised super-resolution.
While playing the video, the system converts the low quality video to a high-quality version by employing super-resolution based on deep convolution neural networks (CNN). The entire process is done in real time, and users can enjoy the high-definition video.
Even with a 17% smaller bandwidth, the system can provide the Quality of Experience equivalent to the latest adaptive streaming service. At a given internet bandwidth, it can provide 43% higher average QoE than the latest service.
Using a deep learning method allows this system to achieve a higher level of compression than the existing video compression methods. Their technology was recognized as a next-generation internet video system that applies super-resolution based on a deep convolution neural network to online videos.
Professor Han said, “So far, it has only been implemented on desktops, but we will further develop applications that work in mobile devices as well. This technology has been applied to the same video transmission systems used by streaming channels such as YouTube and Netflix, and thus shows good signs for practicability.”
This research, led by Hyunho Yeo, Youngmok Jung and Jaehong Kim, was presented at the 13th UNSENIX OSDI conference on October 10 2018 and completed for filing international patent application.
For further information, please click here.
Figure 1. Image quality before (left) and after (right) the technology application
Figure 2. The technology Concept
Figure 3. A transition from low-quality to high quality video after video transmission from the video server
2019.01.22 View 6131 -
KAIST Presents Innovations at CES 2019
Ten of the most innovative technologies spun off from KAIST made a debut at the Consumer Electronics Show (CES) 2019, the world’s largest consumer electronics and IT exhibition being held in Las Vegas from January 8 to 11. The KAIST booth at the CES featured technologies made by KAIST research teams and five startup companies including LiBEST, Memslux, and Green Power. In particular, the KAIST Alumni Association invited 33 aspiring alumni entrepreneurs selected from the KAIST Startup Competition to the show.
At the exhibition, KAIST is presenting innovations in the fields of AI and Bio-IT convergence for the Fourth Industrial Revolution. These include real-time upscaling from Full HD to 4K UHD using AI deep learning-based convolutional neural networks (Professor Munchurl Kim, School of Electrical Engineering) and an AI conversation agent that responds to user’s emotions (Professor Soo-Young Lee, School of Electrical Engineering).
Other technologies include optimal drug target identification by cancer cell type through drug response prediction to be used in personalized cancer treatments (Professor Kwang-Hyun Cho, Department of Bio and Brain Engineering), a nanofiber-based color changing gas sensor with greater sensitivity than conventional paper-based color changing sensors (Professor Il-Doo Kim, Department of Materials Science and Engineering), and functional near-infrared spectroscopy (fNIRS) for brain imaging and muscle fatigue measurement (Professor Hyeonmin Bae, School of Electrical Engineering).
The KAIST booth also features startups founded by KAIST alumni including LiBEST with a flexible lithium polymer secondary cell optimized for smart wearable devices and Rempus with a high-performance lithium ion cell packaging technology for outstanding safety, high capacity, long life, and fast charging.
Green Power and Smart Radar Systems are also joining the booth with a highly efficient and eco-friendly wireless charging system for electrical cars, and a 4D image radar sensor that detects 3D images and speed in real time for applications in self-driving cars, drones, and security systems respectively.
Faculty-founded startup Memslux (CEO Jun-Bo Yoon, School of Electrical Engineering) is presenting a transparent surface light source solution for next-generation display devices.
Associate Vice President of Office of University-Industry Cooperation Kyung Cheol Choi said, “I believe that universities should play a role in connecting technological innovations to business startups for creating value at a global level. In that sense, it is a great opportunity to present innovative technologies from KAIST and promote outstanding KAIST startups at CES 2019. Hopefully, this experience will lead to joint R&D, investment, cooperation, and international technology transfer contracts with leading companies from around the world.”
Here are the five key technologies presented by KAIST at CES 2019.
2019.01.10 View 7072