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The new era of personalized cancer diagnosis and treatment
Professor Tae-Young Yoon
- Succeeded in observing carcinogenic protein at the molecular level
- “Paved the way to customized cancer treatment through accurate analysis of carcinogenic protein”
The joint KAIST research team of Professor Tae Young Yoon of the Department of Physics and Professor Won Do Huh of the Department of Biological Sciences have developed the technology to monitor characteristics of carcinogenic protein in cancer tissue – for the first time in the world.
The technology makes it possible to analyse the mechanism of cancer development through a small amount of carcinogenic protein from a cancer patient. Therefore, a personalised approach to diagnosis and treatment using the knowledge of the specific mechanism of cancer development in the patient may be possible in the future.
Until recently, modern medicine could only speculate on the cause of cancer through statistics. Although developed countries, such as the United States, are known to use a large sequencing technology that analyses the patient’s DNA, identification of the interactions between proteins responsible for causing cancer remained an unanswered question for a long time in medicine.
Firstly, Professor Yoon’s research team has developed a fluorescent microscope that can observe even a single molecule. Then, the “Immunoprecipitation method”, a technology to extract a specific protein exploiting the high affinity between antigens and antibodies was developed. Using this technology and the microscope, “Real-Time Single Molecule co-Immunoprecipitation Method” was created. In this way, the team succeeded in observing the interactions between carcinogenic and other proteins at a molecular level, in real time.
To validate the developed technology, the team investigated Ras, a carcinogenic protein; its mutation statistically is known to cause around 30% of cancers.
The experimental results confirmed that 30-50% of Ras protein was expressed in mouse tumour and human cancer cells. In normal cells, less than 5% of Ras protein was expressed. Thus, the experiment showed that unusual increase in activation of Ras protein induces cancer.
The increase in the ratio of active Ras protein can be inferred from existing research data but the measurement of specific numerical data has never been done before.
The team suggested a new molecular level diagnosis technique of identifying the progress of cancer in patients through measuring the percentage of activated carcinogenic protein in cancer tissue.
Professor Yoon Tae-young said, “This newly developed technology does not require a separate procedure of protein expression or refining, hence the existing proteins in real biological tissues or cancer cells can be observed directly.” He also said, “Since carcinogenic protein can be analyzed accurately, it has opened up the path to customized cancer treatment in the future.”
“Since the observation is possible on a molecular level, the technology confers the advantage that researchers can carry out various examinations on a small sample of the cancer patient.” He added, “The clinical trial will start in December 2012 and in a few years customized cancer diagnosis and treatment will be possible.”
Meanwhile, the research has been published in Nature Communications (February 19). Many researchers from various fields have participated, regardless of the differences in their speciality, and successfully produced interdisciplinary research. Professor Tae Young Yoon of the Department of Physics and Professors Dae Sik Lim and Won Do Huh of Biological Sciences at KAIST, and Professor Chang Bong Hyun of Computational Science of KIAS contributed to developing the technique.
Figure 1: Schematic diagram of observed interactions at the molecular level in real time using fluorescent microscope. The carcinogenic protein from a mouse tumour is fixed on the microchip, and its molecular characteristics are observed live.
Figure 2: Molecular interaction data using a molecular level fluorescent microscope. A signal in the form of spike is shown when two proteins combine. This is monitored live using an Electron Multiplying Charge Coupled Device (EMCCD). It shows signal results in bright dots.
An organism has an immune system as a defence mechanism to foreign intruders. The immune system is activated when unwanted pathogens or foreign protein are in the body. Antibodies form in recognition of the specific antigen to protect itself. Organisms evolved to form antibodies with high specificity to a certain antigen. Antibodies only react to its complementary antigens. The field of molecular biology uses the affinity between antigens and antibodies to extract specific proteins; a technology called immunoprecipitation. Even in a mixture of many proteins, the protein sought can be extracted using antibodies. Thus immunoprecipitation is widely used to detect pathogens or to extract specific proteins.
Technology co-IP is a well-known example that uses immunoprecipitation. The research on interactions between proteins uses co-IP in general. The basis of fixing the antigen on the antibody to extract antigen protein is the same as immunoprecipitation. Then, researchers inject and observe its reaction with the partner protein to observe the interactions and precipitate the antibodies. If the reaction occurs, the partner protein will be found with the antibodies in the precipitations. If not, then the partner protein will not be found. This shows that the two proteins interact.
However, the traditional co-IP can be used to infer the interactions between the two proteins although the information of the dynamics on how the reaction occurs is lost. To overcome these shortcomings, the Real-Time Single Molecule co-IP Method enables observation on individual protein level in real time. Therefore, the significance of the new technique is in making observation of interactions more direct and quantitative.
Additional Figure 1: Comparison between Conventional co-IP and Real-Time Single Molecule co-IP
2013.04.01 View 17209 -
Ligand Recognition Mechanism of Protein Identified
Professor Hak-Sung Kim
-“Solved the 50 year old mystery of how protein recognises and binds to ligands”
- Exciting potential for understanding life phenomena and the further development of highly effective therapeutic agent development
KAIST’s Biological Science Department’s Professor Hak-Sung Kim, working in collaboration with Professor Sung-Chul Hong of Department of Physics, Seoul National University, has identified the mechanism of how the protein recognizes and binds to ligands within the human body.
The research findings were published in the online edition of Nature Chemical Biology (March 18), which is the most prestigious journal in the field of life science.
Since the research identified the mechanism, of which protein recognises and binds to ligands, it will take an essential role in understanding complex life phenomenon by understanding regulatory function of protein.
Also, ligand recognition of proteins is closely related to the cause of various diseases. Therefore the research team hopes to contribute to the development of highly effective treatments.
Ligands, well-known examples include nucleic acid and proteins, form the structure of an organism or are essential constituents with special functions such as information signalling.
In particular, the most important role of protein is recognising and binding to a particular ligand and hence regulating and maintaining life phenomena. The abnormal occurrence of an error in recognition of ligands may lead to various diseases.
The research team focused on the repetition of change in protein structure from the most stable “open form” to a relatively unstable “partially closed form”.
Professor Kim’s team analysed the change in protein structure when binding to a ligand on a molecular level in real time to explain the ligand recognition mechanism.
The research findings showed that ligands prefer the most stable protein structure. The team was the first in the world to identify that ligands alter protein structure to the most stable, the lowest energy level, when it binds to the protein.
In addition, the team found that ligands bind to unstable partially-closed forms to change protein structure.
The existing models to explain ligand recognition mechanism of protein are “Induced Custom Model”, which involves change in protein structure in binding to ligands, and the “Structure Selection Model”, which argues that ligands select and recognise only the best protein structure out of many. The academic world considers that the team’s research findings have perfectly proved the models through experiments for the first time in the world.
Professor Kim explained, “In the presence of ligands, there exists a phenomenon where the speed of altering protein structure is changed. This phenomenon is analysed on a molecular level to prove ligand recognition mechanism of protein for the first time”. He also said, “The 50-year old mystery, that existed only as a hypothesis on biology textbooks and was thought never to be solved, has been confirmed through experiments for the first time.”
Figure 1: Proteins, with open and partially open form, recognising and binding to ligands.
Figure 2: Ligands temporarily bind to a stable protein structure, open form, which changes into the most stable structure, closed form. In addition, binding to partially closed form also changes protein structure to closed form.
2013.04.01 View 10382 -
Top Ten Ways Biotechnology Could Improve Our Everyday Life
The Global Agenda Council on Biotechnology, one of the global networks under the World Economic Forum, which is composed of the world’s leading experts in the field of biotechnology, announced on February 25, 2013 that the council has indentified “ten most important biotechnologies” that could help meet rapidly growing demand for energy, food, nutrition, and health. These new technologies, the council said, also have the potential to increase productivity and create new jobs.
“The technologies selected by the members of the Global Agenda Council on Biotechnology represent almost all types of biotechnology.Utilization of waste, personalized medicine,and ocean agricultureare examples of the challenges where biotechnology can offer solutions,”said Sang Yup Lee, Chair of the Global Agenda Council on Biotechnology and Distinguished Professor in the Department of Chemical and Biomolecular Engineering at the Korea Advanced Institute of Science and Technology (KAIST). He also added that “the members of the council concluded that regulatory certainty, public perception, and investment are the key enablers for the growth of biotechnology.”
These ideas will be further explored during “Biotechnology Week” at the World Economic Forum’s Blog (http://wef.ch/blog) from Monday, 25 February, 2013. The full list follows below:
Bio-based sustainable production of chemicals, energy, fuels and materials
Through the last century, human activity has depleted approximately half of the world’s reserves of fossil hydrocarbons. These reserves, which took over 600 million years to accumulate, are non-renewable and their extraction, refining and use contribute significantly to human emissions of greenhouse gases and the warming of our planet. In order to sustain human development going forward, a carbon-neutral alternative must be implemented. The key promising technology is biological synthesis; that is, bio-based production of chemicals, fuels and materials from plants that can be re-grown.
Engineering sustainable food production
The continuing increase in our numbers and affluence are posing growing challenges to the ability of humanity to produce adequate food (as well as feed, and now fuel). Although controversial, modern genetic modification of crops has supported growth in agricultural productivity. In 2011, 16.7 million farmers grew biotechnology-developed crops on almost 400 million acres in 29 countries, 19 of which were developing countries. Properly managed, such crops have the potential to lower both pesticide use and tilling which erodes soil.
Sea-water based bio-processes
Over 70% of the earth surface is covered by seawater, and it is the most abundant water source available on the planet. But we are yet to discover the full potential of it. For example with halliophic bacteria capable of growing in the seawater can be engineered to grow faster and produce useful products including chemicals, fuels and polymeric materials. Ocean agriculture is also a promising technology. It is based on the photosynthetic biomass from the oceans, like macroalgae and microalgae.
Non-resource draining zero waste bio-processing
The sustainable goal of zero waste may become a reality with biotechnology. Waste streams can be processed at bio-refineries and turned into valuable chemicals and fuels, thereby closing the loop of production with no net waste. Advances in biotechnology are now allowing lower cost, less draining inputs to be used, including methane, and waste heat. These advances are simplifying waste streams with the potential to reduce toxicity as well as support their use in other processes, moving society progressively closer to the sustainable goal of zero waste.
Using carbon dioxide as a raw material
Biotechnology is poised to contribute solutions to mitigate the growing threat of rising CO2 levels. Recent advances are rapidly increasing our understanding of how living organisms consume and use CO2. By harnessing the power of these natural biological systems, scientists are engineering a new wave of approaches to convert waste CO2 and C1 molecules into energy, fuels, chemicals, and new materials.
Regenerative medicine
Regenerative medicine has become increasingly important due to both increased longevity and treatment of injury. Tissue engineering based on various bio-materials has been developed to speed up the regenerative medicine. Recently, stem cells, especially the induced pluripotent stem cells (iPS), have provided another great opportunity for regenerative medicine. Combination of tissue engineering and stem cell (including iPS) technologies will allow replacements of damaged or old human organs with functional ones in the near future.
Rapid and precise development and manufacturing of medicine and vaccines
A global pandemic remains one of the most real and serious threats to humanity. Biotechnology has the potential to rapidly identify biological threats, develop and manufacture potential cures. Leading edge biotechnology is now offering the potential to rapidly produce therapeutics and vaccines against virtually any target. These technologies, including messenger therapeutics, targeted immunotherapies, conjugated nanoparticles, and structure-based engineering, have already produced candidates with substantial potential to improve human health globally.
Accurate, fast, cheap, and personalized diagnostics and prognostics
Identification of better targets and combining nanotechnology and information technology it will be possible to develop rapid, accurate, personalized and inexpensive diagnostics and prognostics systems.
Bio-tech improvements to soil and water
Arable land and fresh water are two of the most important, yet limited, resources on earth. Abuse and mis-appropriation have threatened these resources, as the demand on them has increased. Advances in biotechnology have already yielded technologies that can restore the vitality and viability of these resources. A new generation of technologies: bio-remediation, bio-regeneration and bio-augmentation are being developed, offering the potential to not only further restore these resources, but also augment their potential.
Advanced healthcare through genome sequencing
It took more than 13 years and $1.5 billion to sequence the first human genome and today we can sequence a complete human genome in a single day for less than $1,000. When we analyze the roughly 3 billion base pairs in such a sequence we find that we differ from each other in several million of these base pairs. In the vast majority of cases these difference do not cause any issues but in rare cases they cause disease, or susceptibility to disease. Medical research and practice will increasingly be driven by our understanding of such genetic variations together with their phenotypic consequences.
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An efficient strategy for developing microbial cell factories by employing synthetic small regulatory RNAs
A new metabolic engineering tool that allows fine control of gene expression level by employing synthetic small regulatory RNAs was developed to efficiently construct microbial cell factories producing desired chemicals and materials
Biotechnologists have been working hard to address the climate change and limited fossil resource issues through the development of sustainable processes for the production of chemicals, fuels and materials from renewable non-food biomass. One promising sustainable technology is the use of microbial cell factories for the efficient production of desired chemicals and materials. When microorganisms are isolated from nature, the performance in producing our desired product is rather poor. That is why metabolic engineering is performed to improve the metabolic and cellular characteristics to achieve enhanced production of desired product at high yield and productivity. Since the performance of microbial cell factory is very important in lowering the overall production cost of the bioprocess, many different strategies and tools have been developed for the metabolic engineering of microorganisms.
One of the big challenges in metabolic engineering is to find the best platform organism and to find those genes to be engineered so as to maximize the production efficiency of the desired chemical. Even Escherichia coli, the most widely utilized simple microorganism, has thousands of genes, the expression of which is highly regulated and interconnected to finely control cellular and metabolic activities. Thus, the complexity of cellular genetic interactions is beyond our intuition and thus it is very difficult to find effective target genes to engineer. Together with gene amplification strategy, gene knockout strategy has been an essential tool in metabolic engineering to redirect the pathway fluxes toward our desired product formation. However, experiment to engineer many genes can be rather difficult due to the time and effort required; for example, gene deletion experiment can take a few weeks depending on the microorganisms. Furthermore, as certain genes are essential or play important roles for the survival of a microorganism, gene knockout experiments cannot be performed. Even worse, there are many different microbial strains one can employ. There are more than 50 different E. coli strains that metabolic engineer can consider to use. Since gene knockout experiment is hard-coded (that is, one should repeat the gene knockout experiments for each strain), the result cannot be easily transferred from one strain to another.
A paper published in Nature Biotechnology online today addresses this issue and suggests a new strategy for identifying gene targets to be knocked out or knocked down through the use of synthetic small RNA. A Korean research team led by Distinguished Professor Sang Yup Lee at the Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), a prestigeous science and engineering university in Korea reported that synthetic small RNA can be employed for finely controlling the expression levels of multiple genes at the translation level. Already well-known for their systems metabolic engineering strategies, Professor Lee’s team added one more strategy to efficiently develop microbial cell factories for the production of chemicals and materials.
Gene expression works like this: the hard-coded blueprint (DNA) is transcribed into messenger RNA (mRNA), and the coding information in mRNA is read to produce protein by ribosomes. Conventional genetic engineering approaches have often targeted modification of the blueprint itself (DNA) to alter organism’s physiological characteristics. Again, engineering the blueprint itself takes much time and effort, and in addition, the results obtained cannot be transferred to another organism without repeating the whole set of experiments. This is why Professor Lee and his colleagues aimed at controlling the gene expression level at the translation stage through the use of synthetic small RNA. They created novel RNAs that can regulate the translation of multiple messenger RNAs (mRNA), and consequently varying the expression levels of multiple genes at the same time. Briefly, synthetic regulatory RNAs interrupt gene expression process from DNA to protein by destroying the messenger RNAs to different yet controllable extents. The advantages of taking this strategy of employing synthetic small regulatory RNAs include simple, easy and high-throughput identification of gene knockout or knockdown targets, fine control of gene expression levels, transferability to many different host strains, and possibility of identifying those gene targets that are essential.
As proof-of-concept demonstration of the usefulness of this strategy, Professor Lee and his colleagues applied it to develop engineered E. coli strains capable of producing an aromatic amino acid tyrosine, which is used for stress symptom relief, food supplements, and precursor for many drugs. They examined a large number of genes in multiple E. coli strains, and developed a highly efficient tyrosine producer. Also, they were able to show that this strategy can be employed to an already metabolically engineered E. coli strain for further improvement by demonstrating the development of highly efficient producer of cadaverine, an important platform chemical for nylon in the chemical industry.
This new strategy, being simple yet very powerful for systems metabolic engineering, is thus expected to facilitate the efficient development of microbial cell factories capable of producing chemicals, fuels and materials from renewable biomass.
Source: Dokyun Na, Seung Min Yoo, Hannah Chung, Hyegwon Park, Jin Hwan Park, and Sang Yup Lee, “Metabolic engineering of Escherichia coli using synthetic small regulatory RNAs”, Nature Biotechnology, doi:10.1038/nbt.2461 (2013)
2013.03.19 View 9342
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KAIST Develops Wireless Power Transfer Technology for High Capacity Transit
KAIST and the Korea Railroad Research Institute (KRRI) have developed a wireless power transfer technology that can be applied to high capacity transportation systems such as railways, harbor freight, and airport transportation and logistics. The technology supplies 60 kHz and 180 kW of power remotely to transport vehicles at a stable, constant rate.
KAIST and KRRI successfully showcased the wireless power transfer technology to the public on February 13, 2013 by testing it on the railroad tracks at Osong Station in Korea. Originally, this technology was developed as part of an electric vehicle system introduced by KAIST in 2011 known as the On-line Electric Vehicle (OLEV).
OLEV does not need to be parked at a charging station to have a fully powered battery. It gets charged while running, idling, and parking, enabling a reduction in size of the reserve battery down to one-fifth of the battery on board a regular electric car. The initial models of OLEV, a bus and a tram, receive 20 kHz and 100 kW power at an 85% transmission efficiency rate while maintaining a 20cm air gap between the underbody of vehicle and the road surface. OLEV complies with the national and international standards of 62.5 mG, a safety net for electromagnetic fields. In July 2013, for the first time since its development, OLEV will run on a regular road, an inner city route in the city of Gumi, requiring 40 minutes of driving each way.
Today’s technology demonstration offers further support that OLEV can be utilized for large-scale systems. Professor Dong-Ho Cho, Director of Center for Wireless Power Transfer Technology Business Development at KAIST, explained the recent improvements to OLEV:
“We have greatly improved the OLEV technology from the early development stage by increasing its power transmission density by more than three times. The size and weight of the power pickup modules have been reduced as well. We were able to cut down the production costs for major OLEV components, the power supply, and the pickup system, and in turn, OLEV is one step closer to being commercialized.”
If trains receive power wirelessly, the costs of railway wear and tear will be dramatically reduced. There will be no power rails, including electrical poles, required for the establishment of a railway system, and accordingly, lesser space will be needed. Tunnels will be built on a smaller scale, lowering construction costs. In addition, it will be helpful to overcome major obstacles that discourage the construction of high speed railway systems such as noise levels and problems in connecting pantograph and power rails.
KAIST and KRRI plan to apply the wireless power transfer technology to trams in May and high speed trains in September.
2013.03.19 View 11990 -
Launched the Saudi Aramco-KAIST CO2 Management Center in Korea
KAIST and Saudi Aramco, a global energy and petrochemicals enterprise, signed on February 20, 2013 the Master Research and Collaboration Agreement (the Agreement) on joint collaborations in research and development of carbon management between the two entities.
The Agreement was subsequently concluded upon the signing of the Memorandum of Understanding (MOU) between KAIST and Saudi Aramco, dated January 7th, 2013. In the Agreement, the two organizations specified terms and conditions necessary to conduct joint research projects and stipulated governing body for the operation of the Saudi Aramco-KAIST CO2 Management Center.
KAIST and Saudi Aramco, a national oil company for Saudi Arabia, entered into the MOU, in which the two parties shared a common interest in addressing the issue of CO2 capture, CO2storage, CO2 avoidance using efficiency improvements, and converting CO2 into useful chemicals and other materials, and agreed to “create a major research center for CO2” in Korea.
As envisioned by the MOU and its subsequent agreement, KAIST and Saudi Aramco decided to operate an interim office of the Saudi Aramco-KAIST CO2 Management Center at KAIST campus in Daejeon, Korea, pending the establishment of the research center. The full-fledged, independent research facility will be built at a location and during a period to be agreed between the two parties.
Following the signing of the Agreement, there was a celebration event taken place, including a signboard hanging ceremony for the interim research office. A 10-member delegation from Saudi Aramco, which was headed by Vice President of Engineering Services Samir Al-Tubayyeb, Dr. Nam-Pyo Suh, former president of KAIST, Vice President of Research at KAIST Kyung-Wook Paik, and senior representatives from Korean oil and petrochemical companies such as S-Oil, Lotte Chemicals, SK Innovation, and STX attended the event.
Kyung-Wook Paik, Vice President of Research at KAIST, said,
“In order to help find solutions to carbon management, KAIST and Saudi Aramco will facilitate to exchange each party’s complementary technical expertise, gain insight into new research fields, and have access to key sources of talent, while promoting innovation for technology solutions and contributing to the lifelong learning agenda of both organizations.”
Samir Al-Tubayyeb, Vice President of Engineering Services at Saudi Aramco, added that “As a world-leading oil and gas company, Saudi Aramco’s mission is to promote the continued use of safe, environmentally-friendly petroleum products with a vision to becoming a global leader in research and technology. Building a strong and cooperative relationship with KAIST in our endeavor to search for alternative ways to better utilization of fossil fuels will expedite the creation of opportunities to make the world environmentally safer and sustainable.”
KAIST and Saudi Aramco will each chip in a maximum of USD 5 million annually for the establishment and operation of the Saudi Aramco-KAIST CO2 Management Center during the initial term of the Master Research and Collaboration Agreement, which starts in 2013 and continues through 2018.
2013.03.19 View 13061 -
KAIST and Saudi Aramco agreed to establish a joint CO2 research center in Korea
The Korea Advanced Institute of Science and Technology (KAIST) and Saudi Aramco, a global energy and petrochemicals enterprise, signed a memorandum of understanding (MOU) on January 6, 2013 in Dhahran, Saudi Arabia and pledged to jointly collaborate in research and development of innovative technologies and solutions to address the world"s energy challenges.
Under the MOU, the two entities agreed to establish a research center, Saudi Aramco-KAIST CO2 Research Center, near KAIST"s main campus in Daejeon, Korea. The research center, to be jointly managed by KAIST and Saudi Aramco, will foster and facilitate research collaborations in areas such as tackling carbon dioxide (CO2) emissions by removal or capture of CO2, conversing CO2 into useful products, developing efficiency improvements in energy production, sharing carbon management technologies, establishing exchange programs, and conducting joint projects.
According to Saudi Aramco, the company"s collaboration with KAIST is the first partnership established in Asia. Khalid A. Al-Falih, President and CEO of Saudi Aramco, said,
"The CO2 Research Center represents a major step in Saudi Aramco"s research and technology strategy to partner with top global institutions to help address and find sustainable solutions to the world’s energy challenge both domestically and internationally."
2013.03.19 View 9164
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KAIST Inaugurates Its 15th President
President Sung-Mo “Steve” Kang praised what KAIST has achieved as a powerful engine for the economic and industrial advancement of Korea over the past 41 years, while pledging to continue its endeavor “to go above and beyond its present accomplishments.”
KAIST inaugurated its 15th president, Sung-Mo “Steve” Kang, on February 27, 2013, in a ceremony at the auditorium of its main campus in Daejeon, South Korea. President Kang delivered his inauguration speech to 1,000 distinguished guests from government and public offices and the nation’s science community, including Chairman Myung Oh of the KAIST Board of Trustees, Former Presidents of KAIST Soon-Dal Choi and Chang-Sun Hong, Former National Assembly Member Yong-Kyung Lee, and members of the university.
In his speech, President Kang recalled that he had formed a strong bond with KAIST over many years, before assuming the presidency and extolled the university’s contribution to Korea’s current economic prowess. Referring to the “growing pains” that KAIST has experienced amid its successes, he vowed to unify the university community to take another leap forward:
We must ease the pain through trust and consideration for one another and join in unity to take steps toward the brighter tomorrow of KAIST. I humbly seek your help and pledge to put forth my utmost effort as a servant and leader.
Speaking of KAIST’s importance to the Korean nation, President Kang said, “Korea, as a nation lacking a deep pool of natural resources, must find innovative ways to compete globally to ensure the prosperity and well-being of its people.” He emphasized KAIST’s role as a catalyst to “lead the nation toward the frontiers of science and technology with fervor and responsibility.”
In order to become a global leader in higher learning and contribute to the advancement of science and technology in Korea and beyond, President Kang said that KAIST must do well in five areas with letters matching those of its own acronym: Knowledge creation, Advancement on all fronts, Integrity, Sustainability, and Trust.
In knowledge creation, the president pointed out the necessity of collaboration, student-centered and faculty-led research programs, and interdisciplinary research. For advancement on all fronts, he proposed redrafting KAIST’s future blueprint by consulting with all of its constituents and the Board of Trustees to improve the overall efficiency of the university.
President Kang added that KAIST should uphold integrity in all research publications, financial management, and human relations to withstand unforeseen challenges and problems and that is should seek sustainable value for education and research, not becoming overly driven by short-term research goals. Last, he said that KAIST must be an institution trusted by the public and KAIST faculty, students, and staff. This culture of trust can be made possible, he added, when the members of the university do their best to create an environment of understanding and caring for each other.
President Kang concluded his remarks by promising that he would always open his door and welcome anyone for visits, discussions, and sharing. Known as “Captain Smooth” for the well-rounded, warm, yet decisive leadership style that he showed during his chancellorship at the University of California, Merced, President Kang now pledges to guide KAIST to become better and stronger in the next four years. For a full transcript of the speech, download the PDF file below.
2013.03.13 View 7465 -
New Technology Will Enable the Commercialization of Plasmon Displays
-- Enhancements in the penetration ratios of color filters are expected by applying nano-surface plasmon effects. --
-- Color filter technology will be applicable to large-area OLED and LCD. --
The fabrication technology to commercialize display color filters using plasmon effects has been discovered.
A joint research team headed by Professor Kyung Cheol Choi from the Department of Electrical Engineering of the Korea Advanced Institute for Science and Technology and Prof. Byeong-Kwon Ju from the School of Electrical Engineering of Korea University has developed the technology to design and produce a display color filter by applying nano-surface plasmon effects.
Color filters are core components used to express colors in CMOS image sensors found in LCD/OLED displays or digital cameras. The current color filters have penetration ratios of 20~30%, but the objective of the joint research team is to raise this penetration ratio by over 40% to facilitate the mass production of energy-efficient plasmonic displays.
Currently available plasmonic color filters are limited to applications on micrometer scales. However, outcomes of the newest research extend the size of the applications up to 2.5 cm by using laser interference lithography. The academic and industrial sectors agree that it is now possible to mass-produce displays using plasmonic color filters.
The researchers built a nanohole array to large scale by using laser interference lithography, a technology that forms nanostructures with laser light interferences. They also suggested a new manufacturing process that can optimize the features of color filters while compensating for defects arising from the fabrication stages.
The new manufacturing process of applying laser interference lithography is expected to overcome the shortcomings of traditional color filters by simplifying production and, enabling them to be produced at lower costs.
“There were limitations to industrial applications of plasmon effect due to production costs, time, and yields,” explained Yun Seon Do, a Ph. D. candidate in the Department of Electrical Engineering of KAIST. “The new technology can reduce fabrication time and cost to the extent that it would be advisable to replace dye-based and pigment-based color filter technology."
“This research can be applied to large-scale displays, such as TV screens, by using laser-interference lithography,” said Jung-Ho Park, a Ph. D. candidate in the School of Electrical Engineering of Korea University. “The research outcome is expected to be widely applied in advanced nano-manufacturing processes as it does not restrict the types of circuit boards."
The research outcome, led by doctoral candidates Do and Park, appeared on the front cover of the second issue of Advanced Optical Materials, a highly regarded academic journal in the field of nanotechnologies, and the team has applied for six related patents.
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President Sung-Mo 'Steve' Kang Welcomed the Class of 2017
KAIST held its 2013 Opening Convocation on Monday, March 4, 2013, on its campus in Daejeon, South Korea, with 717 newly arrived freshmen and their parents, family, and friends.
In his welcoming speech, President Sung-Mo “Steve” Kang congratulated the students on their admission to KAIST after a rigorous selection process. President Kang advised the freshmen to follow four principles for successful college lives: development of good character and integrity, acquisition of diverse knowledge and experiences, global awareness, and establishment of fellowship and friendship. For a full transcript of the speech, download the PDF file below.
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Op-Ed by Professor David Helfman: Global Science and Education in Korea for the 21st Century
Professor David Helfman from the Department of Biological Sciences and Graduate School of Nanoscience and Technology contributed an op-ed, “Global Science and Education in Korea for the 21st Century, to the Korea Herald on February 20, 2013. For the article, please click the link below:
http://www.koreaherald.com/view.php?ud=20130220000623.
2013.02.26 View 9410
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2013 Graduation Ceremony Held on February 22
KAIST held a graduation ceremony for the year 2013 at Ryu Keun-Chul Sports Complex on February 22nd.
A total of 2,475 academic degrees were awarded this day, including 482 doctoral degrees, 1,153 master’s degrees, 838 bachelor’s degrees, and two honorary doctorates to Dr. Han Seung-Soo, a former prime minister of South Korea, and Lee Soo-young, the chairwoman of Kwang Won Industrial Co. Ltd. This commencement made KAIST to have turned out overall 46,117 talented graduates – 9,383 doctorates, 23,941 master’s degrees, and 12,793 bachelor’s degrees – to the fields of science and technology since its establishment in 1971.
The Minister of Education and Science Technology Award, which is for the student receiving bachelor’s degree with the highest academic performance, was given to Seung-Uk Jang from the Department of Mathematical Sciences. In addition, the Chairman of the KAIST Board of Trustees Award was given to Chi-Heon Kwon from the Department of Chemistry, KAIST Presidential Award to Yong-Jin Park from the Department of Chemical and Biomolecular Engineering, President of Alumni Association Award to Bong-Soo Choi from the Department Electrical Engineering, and School Supporting Association’s Award to Bo-Kyung Kim from the Bio and Brain Engineering Department.
“Climate changes due to humanity’s economic activities are threatening crucial resources such as water, food, and energy security,” said Former Prime Minister Han Seung-Soo, who received an honorary doctorate at the commencement ceremony. “Please try to solve the greatest issues that human society is facing,” he entreated in his congratulatory message.
“Use the excellent education that you have received at KAIST wisely with good purpose and ethics,” also congratulated President Suh Nam-Pyo. “I hope the graduating students of KAIST to become global leaders in the near future,” he said to the graduates entering the society.
“It was a great honor to contribute as the president of KAIST for almost 7 years, which has been the most challenging and worthwhile time in my life,” he delivered words of gratitude to all members of KAIST. “I appreciate everyone’s efforts for KAIST to develop so far.”
President Suh completed his duty as the fourteenth president of KAIST with the ceremony and returned to the United States on the 25th.
2013.02.26 View 8609