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New BioFactory Technique Developed using sRNAs
Professor Sang Yup Lee
- published on the online edition of Nature Biotechnology. “Expected as a new strategy for the bio industry that may replace the chemical industry.”-
KAIST Chemical & Biomolecular engineering department’s Professor Sang Yup Lee and his team has developed a new technology that utilizes the synthetic small regulatory RNAs (sRNAs) to implement the BioFactory in a larger scale with more effectiveness.
* BioFactory: Microbial-based production system which creates the desired compound in mass by manipulating the genes of the cell.
In order to solve the problems of modern society, such as environmental pollution caused by the exhaustion of fossil fuels and usage of petrochemical products, an eco-friendly and sustainable bio industry is on the rise. BioFactory development technology has especially attracted the attention world-wide, with its ability to produce bio-energy, pharmaceuticals, eco-friendly materials and more.
For the development of an excellent BioFactory, selection for the gene that produces the desired compounds must be accompanied by finding the microorganism with high production efficiency; however, the previous research method had a complicated and time-consuming problem of having to manipulate the genes of the microorganism one by one.
Professor Sang Yup Lee’s research team, including Dr. Dokyun Na and Dr. Seung Min Yoo, has produced the synthetic sRNAs and utilized it to overcome the technical limitations mentioned above.
In particular, unlike the existing method, this technology using synthetic sRNAs exhibits no strain specificity which can dramatically shorten the experiment that used to take months to just a few days.
The research team applied the synthetic small regulatory RNA technology to the production of the tyrosine*, which is used as the precursor of the medicinal compound, and cadaverine**, widely utilized in a variety of petrochemical products, and has succeeded developing BioFactory with the world’s highest yield rate (21.9g /L, 12.6g / L each).
*tyrosine: amino acid known to control stress and improve concentration
**cadaverine: base material used in many petrochemical products, such as polyurethane
Professor Sang Yup Lee highlighted the significance of this research: “it is expected the synthetic small regulatory RNA technology will stimulate the BioFactory development and also serve as a catalyst which can make the chemical industry, currently represented by its petroleum energy, transform into bio industry.”
The study was carried out with the support of Global Frontier Project (Intelligent Bio-Systems Design and Synthesis Research Unit (Chief Seon Chang Kim)) and the findings have been published on January 20th in the online edition of the worldwide journal Nature Biotechnology.
2013.02.21 View 13267 -
Professor Hwang Kyu Young and Professor Yang Dong Yeol Receives Engineer of Korea Award
Emeritus Professor Hwang Kyu Young (Department of Computer Sciences) and Professor Yang Dong Yeol (Department of Mechanical Engineering) were named as the 2012 Engineer of Korea by the Ministry of Education, Science, and Technology and Korea Science Foundation.
The Engineer of Korea Award is awarded biannually to scientists and engineers that have contributed to the development of Korea’s science and technology and national economy.
Professor Hwang’s work with DBMS and close coupling architecture of information search and overall new theories and application technology development in the field of database system has aided the opening and expansion of IT software industry development and the advent of internet information culture era.
Professor Yang is a word renowned scholar in the field of net shape manufacturing and is considered to have opened a new page in the field of nano-molding technique.
In addition, Professor Eum Sang Il (Department of Mathematical Science) has been selected as the 2012 Young Scientist Award.
2013.01.22 View 13620
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KAIST Professors win 2012 Korea Engineering Award
Distinguished Professor Hwang Gyu Young (Department of Computer Science) and Professor Yang Dong Yol (Department of Mechanical Engineering) from KAIST received the 2012 ‘Korea Engineering Award’ hosted by the Ministry of Education, Science and Technology and the Korea Research Foundation.
The ‘Korea Engineering Award’ is given biennially to researchers who have accomplished world class research and have contributed greatly to Korea’s development in the field of Science and Technology. The award started in 1994 and a total of 24 recipients were recognized in various fields such as electronics, mechanics, chemistry, construction, etc. The recipients of the award areawarded the Presidential award as well as 50million won as prize money.
Professor Hwang was recognized for his research on DBMS close-coupling architecture as well as other new data base system theories, contributing to the development of the IT software industry in Korea. Professor Yang was praised for his work in precision shape creation and manufacturing, especially for his work in the nano-stereolithography process.
In addition, Professor Oum Sang-il from the Deparment of Mathematical Science received the 2012 ‘Young Scientist Award’ hosted by the Ministry of Education, Science and Technology and the Korean Academy of Science and Technology.
The ceremony for ‘Korea Engineering Award’ and the ‘Young Scientist Award’ was held in Seoul Press Center Press Club on the 21st of December.
2012.12.26 View 15505 -
Ph.D. students Hyowon Park and Won Ma receive Grand Prizes in Mathematics and Biology respectively.
Researchers in KAIST received best paper awards in two out of three fields at this year’s award ceremony for the “Second Annual Best Thesis Paper Award” held collectively by the Korea University Presidents’ Federation (with Chairman DaeSoon Lee) and the Korean Academy of Science and Technology (with Director GilSang Jung).
Two researchers from KAIST, Hyowon Park (Department of Mathematics) and Won Ma (Department of Biology) received best paper awards.
This prize, given by the both the Korea University Presidents’ Federation and the Korean Academy of Science and Technology since last year, is awarded to researchers and assistant professors who write the most outstanding thesis papers in the field of basic sciences.
Park, who received the best paper award this year, did research on graph braid groups. He was supervised by Professor Kihyung Ko, who received the best supervisor reward.
Ma, who received the best paper award in the field of biological science, researched about the Attention Deficit/Hyperactivity Disorder due to deficiency of the GIT1 synapse protein. His supervising professor also received the supervisor award.
The award ceremony was held in the auditorium of the S-OIL headquarters in Seoul on November 30.
Meanwhile, NASA researcher Jaehwa Lee received the best paper award in the field of earth science, and his supervising professor, Professor Jun Kim from Yonsei University who studies atmospheric science, received the best supervisor award.
2012.12.21 View 12446
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KAIST shocks the world with its creativity
Researchers at KAIST yielded great results at the world’s leading international Human Computer Interaction Society.
Professor Lee Gi Hyuk’s (Department of Computer Sciences) and Professor Bae Seok Hyung’ (Department of Industrial Design) respective teams received awards in two criteria in student innovation contest and was the only domestic university that presented their thesis at the ACM Symposium on User Interface Software.
The ACM UIST holds a student innovation contest prior to its opening. This year’s topic was the pressure sensing multi touch pad of Synaptics and involved 27 prestigious universities including MIT and CMU.
The KAIST team (Ki Son Joon Ph.D. candidate, Son Jeong Min M.A. candidate of Department of Computer Sciences and Woo Soo Jin M.A. candidate of Department of Industrial Design) designed a system that allows modulated control by attaching a simple structure to the pressure sensing multi touch pad.
The second KAIST team (Huh Seong Guk Ph.D. candidate, Han Jae Hyun Ph.D. candidate, Koo Ji Sung Ph.D. candidate at the Department of Computer Sciences, and Choi Ha Yan M.A. candidate at Department of Industrial Design) designed a system that utilizes a highly elastic fiber to allow the sensing of lateral forces. They also created a slingshot game application which was the second most popular system.
In the thesis session Professor Bae’s team (Lee DaWhee Ph.D. candidate, Son Kyung Hee Ph.D. candidate, Lee Joon Hyup M.A. candidate at Department of Industrial Design) presented a thesis that dealt with the technology that innovated the table pen for displays.
The new ‘phantom pen’ solved the issue arising from the hiding effect of the pen’s contact point and the display error due to the thickness of the display. In addition the ‘phantom pen’ has the ability to show the same effects as crayons or markers in a digital environment.
2012.11.29 View 12853
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Professor Soon-Heung Chang meets with Bill Gates and discusses possible collaboration
Professor Soon-Heung Chang from the Department of Nuclear and Quantum Engineering, KAIST, who is also the president of Korea Nuclear Society (KNS), met Bill Gates, the co-founder and former chief executive officer (CEO) of Microsoft, on August 16, 2012 and discussed ways to cooperate for the development of a sodium-cooled fast reactor (SFR), a next generation nuclear power reactor.
According to Professor Chang, Bill Gates was amazed at Korea’s successful bids for nuclear power plants in the United Arab Emirates, even though Korea was a latecomer in the field of nuclear power. Bill Gates also showed a keen interest in Korea’s low electricity rates.
Gates focuses on solving fundamental problems in order to help improve the quality of life for humanity, rather than short-term temporary solutions, through infrastructure development such as energy. Particularly, he considers nuclear power as one of the most effective ways to supply clean energy which can provide electricity at a low cost while keeping carbon dioxide emission levels much lower than fossil fuels.
Bill Gates is a primary investor for an energy company called “TerraPower” based in Bellevue, Washington. TerraPower develops and commercializes nuclear power technology for a traveling wave reactor (TWR) that is designed to use spent fuels, i.e., depleted uranium, and runs technically “forever” because once fueled, the reactor does not need to be refueled for over 50 years. TerraPower’s TWR is to use metallic fuel, and Korea is the only country that currently develops SFR (KALIMER 600) using metallic fuel.
“Korea has an outstanding supply chain for the entire lifecycle of a nuclear power station from equipment manufacturing to operation,” said Professor Chang, while emphasizing the synergistic effects of forming partnership between Korea and TerraPower.
Professor Chang emphasized that Korea should create an opportunity based on lessons learned from the Fukushima crisis and actively move forward to achieve its leading position in the field of next generation nuclear reactors. He said that cooperation with Bill Gates will be a significant step towards the development of next generation nuclear reactors.
About Sodium-cooled Fast Reactor (SFR)
Sodium-cooled Fast Reactor (SFR) is a next-generation nuclear power reactor that will use spent fuels from conventional reactors. Arrangement of a fuel recycling system in
conjunction with currently-developing pyroprocessing technology would enable U-238, which makes up over 99% of natural uranium, to be used as a nuclear fuel. This would greatly reduce the toxicity and volume of spent fuels by up to 1,000 times and 100 times respectively when compared to existing reactors. This is truly a breakthrough innovation in spent fuel disposal and recycling.
2012.09.20 View 11835 -
New wireless charging device developed
The On-line Electric Vehicle (OLEV) developed by KAIST has made a step towards commercialization with the development of a more economic wireless charging device.
Professor Chun-Taek Rim from the Department of Nuclear and Quantum Engineering at KAIST has developed a new I-shaped wireless charging device that differs from the pre-existing rail-type electricity feeder. This device can be modularly produced and requires relatively less construction, significantly reducing the cost of implementation.
The KAIST OLEV is a new concept electric car that has a special electricity collecting device underneath it. The car’s battery is charged by magnetic fields produced from electric lines buried 15cm underneath the road. The vehicle was first tested in 2009, making it the first wireless electric car in the world. OLEV can be charged during stoppage time between traffic lights and receives real-time power when running. OLEV is currently in operation at the KAIST Munji Campus in Daejeon and is also being exhibited at the Yeosu Expo and Seoul Grand Park.
The device itself has a charging capacity of 15kW, and the electricity is supplied through an electricity feeder with a width of 80cm with a space interval of 20cm. Despite being hailed as a technological breakthrough and revolutionary concept, KAIST OLEV has been criticized for problems in commercialization, due to the difficulties in installing wires beneath existing roads, which costs a considerable amount of money.
The new I-shaped wireless charging device reduces the width of the electricity feeder by 10cm, a mere one-eighth of the size of the previous version, and greatly increases the charging power to 25kW. Furthermore, the left and right permissible space of automobiles has increased to 24cm and the magnetic field complies with the international design guidelines, making the OLEV safe for the human body.
The reduction of the width has made the mass production of modules possible, making the installation of KAIST OLEV more economical and marketable. Professor Rim emphasized that compared with the existing rail-type electricity feeder, the new technology will need only one-tenth of the construction time and 80% of the cost, significantly improving OLEV’s constructability and workability.
The research was published in the IEEE Transactions on Power Electronics last December, and Professor Rim was invited to talk at the Conference on Electric Roads & Vehicles, which was held in February in the United States, about the new technology.
2012.07.06 View 13109
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President Nam Pyo Suh receives Honorary Doctorate from Bilkent University, Turkey
President of KAIST Nam Pyo Suh received an Honorary Doctorate from Turkey’s Bilkent University on June 13th, 2012.
Bilkent University revealed that it is President Suh’s invention of a plastic manufacture process used all over the world and the combination of academic achievements like the creation of the axiomatic design theory that merits the Honorary Doctorate.
After the presentation ceremony, President Suh gave a lecture to professors and students at Bilkent University on the "University of the Future: Changing Education Paradigm."
Bilkent University is located in Ankara, the capital of Turkey and was established in 1984, which is largely regarded as Turkey’s best private university. It ranked 32 out of 50 universities in Times Higher Educations’ 100 Under 50 List of World’s Best New Universities.
2012.06.18 View 10014 -
Korea's First MOU between a University Education Volunteer Work Group and Local Government
- 200 Adolescents from Yuseong-gu to Receive Education Community Services
Midam Scholarship committee which is composed of KAIST"s students and graduates, will draw up a contract that states that it will work together with the Yuseong-gu municipality for the development of the district education services on the 14th at the Yuseong-gu office.
Both sides will together ▲mentor the local students, ▲cooperate to run and develop creative programs, ▲exchange work for the development of the KAIST Midam Scholarship Committee, ▲conduct various other projects.
From now, the Midam Scholarship Committee will teach about 200 students in Yuseong-gu. The drawing of this contract has much meaning in that it is the first of its kind.
The Midam Scholarship Committee was founded on 2009 by students in KAIST to teach math, english, and science to students from families with low income levels.
This committee has made educational pacts with middle and high schools located in Daejeong such as Chungnam High School and Beobdong High School, and has not only taught these students but also has given scholarships to the selected students.
On one hand, the Midam Scholarship Committee has also supported 10 students in KAIST who were in need with 300000won each on the 6th. This fund was raised through the donations of alumni and mentoring projects.
The Midam Scholarship Committee has been recognized for its positive impacts on the society and has received an award from the Yuseong-gu municipality office.
2012.05.10 View 9816
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Op-Ed by MIT President, Manufacturing a Recovery, New York Times, August 29, 2011
New York Times carried an opinion piece of MIT President, Susan Hockfield. Dr. Hockfield put emphasis on the importance of recovering manufacturing to revive the US economy and suggested investments in the development of high technology and “tight integration of design production” through “networks of innovation, lab research to new production processes, and business models.” For the op-ed piece, please go to
http://www.nytimes.com/2011/08/30/opinion/manufacturing-a-recovery.html?_r=2.
2011.08.31 View 11517
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Displaybank, KAIST Develops Flexible Display Metal Wiring Technology, May 27, 2011
On May 26, Korea Advanced Institute of Science (KAIST) announced that team of Prof. Yang from the Department of Mechanical Engineering developed flexible display metal wiring manufacturing-technology. For the article, please follow the link,
http://www.displaybank.com/eng/info/sread.php?id=5877
2011.05.31 View 10191
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Remote Follows Your Thumb by Discovery News, May 19, 2011
The ACM CHI Conference on Human Factors in Computing Systems, an international conference of human-computer interaction, was held on May 7-12, 2011 in Vancouver, Canada. At the conference, KAIST’s research team presented a paper on the development of prototype, called "remote touch system," for manipulating a LED screen by putting user’s thumb’s shadow on a television or smart phone screen. Discovery News posted an online article on the technology, dated May 19, 2011. For the article, please copy and paste the following link in the address bar of Internet Explorer:
http://news.discovery.com/tech/shadow-remote-touchscreen-110519.html?print=true
2011.05.20 View 10012