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The hereditary factor of autism revealed
Korean researchers have successfully investigated the causes and hereditary factors for autistic behavior and proposed a new treatment method with fewer side effects. This research was jointly supported by the Ministry of Education, Science and Technology and the National Research Foundation as part of the Leading Researcher and Science Research Center Program The research findings were publishing in the June edition of Nature magazine and will also be introduced in the July edition of Nature Reviews Drug Discovery, under the title ‘Autistic-like social behavior in Shank2-mutant mice improved by restoring NMDA receptor function’. The research team found that lack of Shank2 genes in mice, which are responsible for the production of synapse proteins, caused autistic-like behavior. The results strongly suggested that the Shank2 gene was linked to autistic behavior and that Shank2 deficiency induced autistic behaviors. Autism is a neural development disorder characterized by impaired social interaction, repetitive behavior, mental retardation, anxiety and hyperactivity. Around 100 million people worldwide display symptoms of autistic behavior. Recent studies conducted by the University of Washington revealed that 1 out of 3 young adults who display autistic behavior do not fit into the workplace or get accepted to college, a much higher rate than any other disorder. However, an effective cure has not yet been developed and current treatments are limited to reducing repetitive behavior. The research team confirmed autistic-like social behavior in mice without the Shank2 genes and that the mice had decreased levels of neurotransmission in the NMDA receptor. The mice also showed damaged synaptic plasticity* in the hippocampus**. * Plasticity: ability of the connectionbetween two neurons to change in strength in response to transmission of information **Hippocampus: part of the brain responsible for short-term and long-term memory as well as spatial navigation. The research team also found out that, to restore the function of the NMDA receptor, the passive stimulation of certain receptors, such as the mGLuR5, yielded better treatment results than the direct stimulation of the NMDA. This greatly reduces the side effects associated with the direct stimulation of receptors, resulting in a more effective treatment method. This research successfully investigated the function of the Shank2 gene in the nerve tissue and showed how the reduced function of the NMDA receptor, due to the lack of the gene, resulted in autistic behavior. It also provided new possibilities for the treatment of autistic behavior and impaired social interaction
2012.06.24
View 9660
Biomimetic reflective display technology developed
Professor Shin Jung Hoon The bright colors of a rainbow or a peacock are produced by the reflection and interference of light in transparent periodic structures, producing what is called a structural color. These colors are very bright and change according to the viewing angle. On the other hand, the wings of a morpho-butterfly also have structural colors but are predominantly blue over a wide range of angles. This is because the unique structure of the morpho-butterfly’s wings contains both order and chaos. Professor Shin Jung Hoon’s team from the Department of Physics and the Graduate School of Nanoscience and Technology at KAIST produced a display that mimics the structure of the morpho-butterfly’s wings using glass beads. This research successfully produced a reflective display (one that reflects external light to project images), which could be used to make very bright displays with low energy consumption. This technology can also be used to make anti-counterfeit bills, as well as coating materials for mobile phones and wallets. The structure of the morpho-butterfly’s wings seems to be in periodic order at the 1-micrometer level, but contains disorder at the 100-nanometer level. So far, no one had succeeded in reproducing a structure with both order and disorder at the nanometer level. Professor Shin’s team randomly aligned differently sized glass beads of a few hundred nanometers to create chaos and placed a thin periodic film on top of it using the semiconductor deposition method, thereby creating the morpho-butterfly-like structure over a large area. This new development produced better color and brightness than the morpho-butterfly wing and even exhibited less color change according to angle. The team sealed the film in thin plastic, which helped to maintain the superior properties whilst making it more firm and paper-like. Professor Shin emphasized that the results were an exemplary success in the field of biomimetics and that structural colors could have other applications in sensors and fashion, for example. The results were first introduced on May 3rd in Nature as one of the Research Highlights and will be published in the online version of the material science magazine, Advanced Materials. This research was jointly conducted by Professor Shin Jung Hoon (Department of Physics / Graduate School of Nanoscience and Technology at KAIST), Professor Park NamKyoo (Department of Electrical and Computer Engineering at Seoul National University), and Samsung Advanced Institute of Technology. The funding was provided by the National Research Foundation of Korea and the Ministry of Education, Science and Technology as part of the World Class University (WCU) project. Figure 2. The biomimetic film can express many different colors Figure 3. The biomimetic diplay and a morpho-butterfly
2012.05.07
View 12073
Closer to the Dream: Graphene
A technique that allows easy and larger observation area of graphene’s crystal face was developed by Korean Research Team. The research team, led by Professor Jeong Hui Tae (KAIST), consists of Doctorate candidate Kim Dae Woo, Dr. Kim Yoon Ho (primary author), Doctorate candidate Jeong Hyun Soo. The research is supported by WCU (World Class Research University) Development Plan, Mid-Aged Researcher Support Business and was published in the online edition of Nature Nanotechnology. (Dissertation: Direct visualization of large0area graphene domains and boundaries by optical birefringency) Professor Jeong’s team used the optical property of the liquid display used in LCD to visualize the size and shape of the single crystals along a flat surface. The visualization of the single crystal allowed the measurement of a near theoretical value of electrical conductivity of graphene. Graphene has great electrical conductivity, transparent, mechanically stable, flexible, and is therefore regarded as the next generation electrical material. However the polycrystalinity of graphene meant that the actual electrical, mechanical properties were lower than the theoretical values. The reason was thought to be because of the size of the crystal faces and boundary structures. Therefore, in order to create graphene that has good properties, observing the domain and boundary of graphene crystal faces is essential. The new technique developed by the research team is another step towards commercializing transparent electrodes, flexible display, and electric materials like solar cells.
2012.01.31
View 8706
Genetic Cause of ADHD (Attention Deficit Hyperactivity Disorder) Found
The cooperative research team consisting research teams under Professor Kim Eun Joon and Professor Kang Chang Won of the department of Biological Sciences discovered that ADHD arises from the deficiency of GIT1 protein in the brain’s neural synapses. ADHD (Attention Deficit Hyperactivity Disorder) is found in around 5% of children around the world and is a disorder where the child becomes unable to concentrate, show over the top responses, and display impulsive behavior. The research team found that the difference between children with ADHD and those without it is one base in the GIT1 gene. The difference of a single base causes the underproduction of this protein, and those children with low levels of the protein had a higher probability to develop ADHD. In addition, further evidence was provided when the research team conducted mice experiments. Those mice with low levels of GIT1 exhibited impulsive and exaggerated reactions like humans with ADHD, had learning disabilities, and produced abnormal brain waves. And upon injecting these mice with cure for ADHD, the symptoms of ADHD disappeared. The impulsive behavior of ADHD children disappears as the child enters adulthood and a similar pattern was found in mice. A mice with low levels of GIT1 showed impulsive behaviors when 2 months old, but these behaviors disappeared as it got older to around 7 months old (equivalent to 20~30 years old for humans). Professor Kim Eun Joon commented that there has to be equilibrium between mechanisms that excite the neurons and mechanisms that calm the neurons, but the lack of GIT1 leads to the decrease in the mechanisms that calm the neurons which causes the impulsive behavior of ADHD patients. In addition, Professor Kang Chang Won commented that the results of the experiment has been receiving rave reviews and is being seen as the new method in the production of the cure for ADHD. The result of the experiment was published in the online edition of Nature Medicine magazine.
2011.04.30
View 9117
The Irish Times: Gene link identified in ADHD, April 18, 2011
The Irish Times wrote an article on the recent research breakthrough made by a KAIST research team to identify a gene that triggers the syndrome of Attention Deficit Hyperactivity Disorder (ADHD) among children. Given the heightened attention to the syndrome across the world, the research result has received a great deal of attention not only from the academia but also from the media and public. For the article, please visit http://www.irishtimes.com/newspaper/ireland/2011/0418/1224294910305.html. The research paper was appeared online April 17, 2011 in Nature Medicine, which will be printed in its May 2011 issue. For the paper, please click the link of http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.2330.html.
2011.04.18
View 8614
Professor Min Beom Ki develops metamaterial with high index of refraction
Korean research team was able to theoretically prove that a metamaterial with high index of refraction does exist and produced it experimentally. Professor Min Beom Ki, Dr. Choi Moo Han, and Doctorate candidate Lee Seung Hoon was joined by Dr. Kang Kwang Yong’s team from ETRI, KAIST’s Professor Less Yong Hee’s team, and Seoul National University’s Professor Park Nam Kyu’s team. The research was funded by the Basic Research Support Program initiated by the Ministry of Education, Science, and Technology and Korea Research Federation. The result of the research was published in ‘Nature’ magazine and is one of the few researches carried out by teams composed entirely of Koreans. Metamaterials are materials that have physical properties beyond those materials’ properties that are found in nature. It is formed not with atoms, but with synthetic atoms which have smaller structures than wavelengths. The optical and electromagnetic waves’ properties of metamaterials can be altered significantly which has caught the attention of scientists worldwide. Professor Min Beom Ki’s team independently designed and created a dielectric metamaterial with high polarization and low diamagnetism with an index of refraction of 38.6, highest synthesized index value. It is expected that the result of the experiment will help develop high resolution imaging system and ultra small, hyper sensitive optical devices.
2011.02.23
View 13878
New Bio-Clock gene and its function found
The Ministry of Education, Science and Technology announced that a Korean research team has found a new gene responsible for maintaining the bio-clock (twenty-four) and its mechanism. Twnety-four was led by Professor Choi Joon Ho and Dr. Lee Jong Bin of KAIST (department of Biology) and was a joint operation with Professor Ravi Allada and Dr.Lim Jeong Hoon of Northwestern University (department of neurobiology) and the result was published in ‘Nature’ magazine. The research team experimented with transformed small fruit flies for 4 years and found that there was an undiscovered gene that deals with the bio rhythm in the brain which they named ‘twenty-four’. The understanding with genes prior to twenty-four was that these genes regulate biorhythm in the transcription phase (DNA to mRNA). Twenty-four operates in the step after transcription when the ribosome creates proteins. Especially twenty-four has a great effect on the ‘period protein’ which acts as a sub-atomic clock that regulates the rhythm and life of each cell. The experiment was innovational in that it was able to scientifically prove the function of the protein produced by the gene. The result is expected to help solve the problems associated with sleep disorders, jetlags, eating rhythms, bio rhythms, etc. The name twenty-four was the fact that a day, a cycle, is 24 hours long and the gene’s serial numbers CG4857 adds up to twenty four.
2011.02.23
View 10091
Waking Up Is Hard to Do: Scientists have discovered a new mechanism in the core gears of the circadian clock.
The US News & World Report released an article (Feb. 18, 2011) on KAIST’s research collaboration with Northwestern University in the US to identify a gene that regulates the rhythm of a fruit fly’s circadian clock, which may be applied to explain human’s sleep-wake cycle. The research result was published February 17 in the journal Nature. For the link of the US News & World Report article, please go to the following link: http://www.usnews.com/science/articles/2011/02/18/waking-up-is-hard-to-do_print.html
2011.02.21
View 8912
"Supersolidity flows back," Nature, September 2, 2010
Supersolidity, discovered for the first time in 2004 by two physicists—one of them is Professor Eun-Seong Kim from the Department of Physics, KAIST—was discussed once again in the September 2, 2010 issue of Nature, an internationally well-known science journal. The article mentioned “supersolidity” as one of the rare examples of quantum effects on a macroscopic scale, together with “superconductivity” and “superfluidity.” The phenomenon of supersolidity was evidenced by Professor Kim and his colleague through an experiment of placing helium-4 in a torsional oscillator under a low temperature. The phenomenon, however, has been in debate among scientists in the physics community since the discovery, and Professor Kim has recently released his research results to further support his claim. For the full article, please click the link below: http://www.nature.com/news/2010/100902/full/news.2010.443.html.
2010.09.08
View 8453
Nature Photonics, a peer-reviewed scientific journal, released a paper written by a KAIST research team on the time-of-flight measurement.
Professor Seung-Woo Kim of the Mechanical Engineering Department, KAIST, and his research team published the result of their study on the measurement of 1 nanometer (nm) precision. “The time-of-flight of light pulses has long been used as a direct measure of distance, but state-of-the-art measurement precision using conventional light pulses or microwaves peaks at only several hundreds of micrometers. Here, we improve the time-of-flight precision to the nanometer regime by timing femtosecond pulses through phase-locking control of the pulse repetition rate using the optical cross-correlation technique,” Professor Kim said. According to the experiment conducted by the research team, “An Allan deviation of 117 nm in measuring a 700m distance in air at a sampling rate of 5 millisecond (ms) once the pulse repetition is phased-locked, which reduces to 7 nm as the averaging time increases to 1 second (s).” When measuring an object located in a far distance, a laser beam is projected to the object, and the reflected light is analyzed; the light is then converted into an electric signal to calculate the distance. In so doing, Professor Kim said, the conventional method of measurement creates at least 1 mm of deviation. He argues, “This enhanced capability is maintained at long range without periodic ambiguity, and is well suited to lidar applications. This method could also be applied to future space missions involving formation-flying satellites for synthetic aperture imaging and remote experiments related to general relativity theory." Nature Photonics published the article online on August 8, 2010.
2010.08.18
View 9699
Professor Eun-Seong Kim and his research staff observed the phenomena of hysteresis and relaxation dynamics from supersolid Helium
Professor Eun-Seong Kim and his research staff observed the phenomena of hysteresis and relaxation dynamics from supersolid Helium. Their research paper was published in Nature Physics for the issue of April 2010. If we take Helium 4 and cool it down at temperatures below 2.176 Kelivin, liquid helium 4 undergoes a phase transition and becomes superfluid with a zero viscosity. The superfluidity was observed in solid helium through an experiment performed by researchers of Pennsylvania State University in 2004. One of the researchers then was Professor Eun-Seong Kim in the Department of Physics, KAIST. Professor Kim and his research staff, Hyung-Soon Choi, Ph.D., recently published their research results in Nature Physics (April 2010), a highly esteemed journal in the field, on the phenomena of hysteresis and relaxation dynamics observed in supersolid Helium. For the paper, please download the attached .pdf file. Nature Physics link: http://www.nature.com
2010.04.13
View 11112
Prof. Ryoo's Team Discovers Breakthrough Method to Create New Zeolite
A group of scientists led by Prof. Ryong Ryoo of the Department of Chemistry, KAIST, has found a method to direct the growth of zeolite, a crystalline substance that is frequently used as catalyst in the chemical and petrochemical industries, the university authorities said on Thursday (Sept. 10). Ryoo"s research team successfully created ultrathin nano-sheets, only two nano-meters thick, that are efficiently used as long-life catalysts for hydrocarbon cracking and other petrochemical applications. The breakthrough finding, which is credited with taking acidic zeolite catalysts to the limit in terms of thickness, was published in the latest edition of the peer-review journal, "Nature." A team from the Polytechnic Univeristy of Valencia, Spain, also contributed to the research. Zeolites are already widely used in the petrochemical industry, but making the catalysts very thin means that reactant molecules can easily diffuse into the zeolite structure and product molecules can get out quickly. This improves the efficiency of the catalyst and reduces unwanted side reactions that can produce polymeric hydrocarbon "coke" that clogs the zeolite pores and eventually kills the catalytic activity, Prof. Yoo said. To make the thin sheets, Ryoo and his team used a surfactant as a template to direct the growth of the zeolite structure. The surfactant molecule has a polar "head" group - with two quaternary ammonium groups around which the aluminosilicate zeolite crystal grows - and a long hydrocarbon "tail," which prevents the sheets from aggregating together into larger, three dimensional crystals. When the surfactant is removed, these flakes pile up randomly with gaps in between which further aids diffusion to the catalyst sites. "Zeolite could be used as a catalyst to convert heavy oil into gasoline. Our new zeolite could provide even more possibilities, such as being used as catalysts for transforming methanol into gasline," Ryoo said. Prof. Ryoo, a Distinguished Professor of KAIST, has won a variety of academic awards, which included the Top Scientist Award given by the Korean government in 2005 and the 2001 KOSEF Science and Technology Award for his work on the synthesis and crystal structure of mezzoporous silica. Ryoo obtained his bachelor"s degree from Seoul National University in 1977, master"s from KAIST in 1979, and doctorate from Stanford University in 1985. In 2006, Ryoo and his research team announced the discovery of a form of zeolite that can catalyze petrochemical reactions much more effectively than previous zeolites. Because of the potential of this to streamline the gasoline refining process, it was greeted as a "magical substance" by the South Korean press.
2009.09.11
View 10797
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