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The 1st Korea Toray Science and Technology Awardee, Prof. Sukbok Chang
(Distinguished Professor Sukbok Chang from the Department of Chemistry) The Korea Toray Science Foundation (KTSF) awarded the first Korea Toray Science Technology Award in basic science to Distinguished Professor Sukbok Chang from the Department of Chemistry on September 19. KTSF was established in January 2018, and its award goes to researchers who have significantly contributed to the development of chemistry and materials research with funds to support research projects. Distinguished Professor Chang has devoted himself in organocatalysis research; in particular, his work on catalysts for effective lactam formation, which was an intricate problem, received great attention. The award ceremony will take place in The Federation of Korean Industries Hall on October 31. KTFS board members, judges, and the CEO of Toray Industries Akihiro Nikkaku will attend the ceremony. Also, Dr. Ryoji Noyori, the Nobel Laureate in Chemistry, will give a talk on the role of chemistry and creative challenges as a researcher.
2018.10.04
View 7069
Engineered E. coli Using Formic Acid and CO2 As a C1-Refinery Platform Strain
(Figure: Formic acid and CO2 assimilation pathways consisting of the reconstructed THF cycle and reverse glycine cleavage reaction. This schematic diagram shows the formic acid and CO2 assimilation procedure through the pathway. Plasmids used in this study and the genetic engineering performed in this study are illustrated.) A research group at KAIST has developed an engineered E. coli strain that converts formic acid and CO2 to pyruvate and produces cellular energy from formic acid through reconstructed one-carbon pathways. The strategy described in this study provides a new platform for producing value-added chemicals from one-carbon sources. Formic acid is a carboxylic acid composed of one carbon. Formic acid was produced from CO2 by the chemical method. Recently, the C1 Gas Refinery R&D Center has successfully developed a biological process that produces formic acid from carbon monoxide for the first time. Formic acid is in a liquid state when at room temperature and atmospheric pressure. In addition, it is chemically stable and less toxic, thus, easy to store and transport. Therefore, it can be used as an alternative carbon source in the microbial fermentation process. In order to produce value-added chemicals using formic acid, a metabolic pathway that converts formic acid into cellular molecules composed of multiple carbons is required. However, a metabolic pathway that can efficiently convert formic acid into cellular molecules has not been developed. This acted as an obstacle for the production of value-added chemicals using formic acid A research group of Ph.D. student Junho Bang and Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering addressed this issue. This study, entitled “Assimilation of Formic Acid and CO2 by Engineered Escherichia coli Equipped with Reconstructed One-Carbon Assimilation Pathways”, has been published online in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) on September 18. There has been increasing interest in utilizing formic acid as an alternative carbon source for the production of value-added chemicals. This research reports the development of an engineered E. coli strain that can convert formic acid and CO2 to pyruvate and produce cellular energy from formic acid through the reconstructed one-carbon pathways. The metabolic pathway that efficiently converts formic acid and CO2 into pyruvate was constructed by the combined use of the tetrahydrofolate cycle and reverse glycine cleavage reaction. The tetrahydrofolate cycle was reconstructed by utilizing Methylobacterium extorquens formate-THF ligase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase. The glycine cleavage reaction was reversed by knocking out the repressor gene (gcvR) and overexpressing the gcvTHP genes that encode enzymes related with the glycine cleavage reaction. Formic acid and CO2 conversion to pyruvate was increased via metabolic engineering of the E. coli strain equipped with the one-carbon assimilation pathway. In addition, in order to reduce glucose consumption and increase formic acid consumption, Candida boidnii formate dehydrogenase was additionally introduced to construct a cellular energy producing pathway from formic acid. This reduces glucose consumption and increases formic acid consumption. The reconstructed one-carbon pathways can supply cellular molecules and cellular energies from the formic acid and CO2. Thus, the engineered E. coli strain equipped with the formic acid and CO2 assimilation pathway and cellular energy producing pathway from formic acid showed cell growth from formic acid and CO2 without glucose. Cell growth was monitored and 13C isotope analysis was performed to confirm E. coli growth from the formic acid and CO2. It was found that the engineered E. coli strain sustained cell growth from the formic acid and CO2 without glucose. Professor Lee said, “To construct the C1-refinery system, a platform strain that can convert one-carbon materials to higher carbon materials needs to be developed. In this report, a one-carbon pathway that can efficiently convert formic acid and CO2 to pyruvate was developed and a cellular energy producing pathway from formic acid was introduced. This resulted in an engineered E. coli strain that can efficiently utilize formic acid as a carbon source while glucose consumption was reduced. The reconstructed one-carbon pathways in this research will be useful for the construction of the C1-refinery system.” This work was supported by the C1 Gas Refinery Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2016M3D3A1A01913250). For further information: Sang Yup Lee, Distinguished Professor of Chemical and Biomolecular Engineering, KAIST (leesy@kaist.ac.kr, Tel: +82-42-350-3930)
2018.09.18
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Adding Smart to Science Museum
KAIST and the National Science Museum (NSM) created an Exhibition Research Center for Smart Science to launch exhibitions that integrate emerging technologies in the Fourth Industrial Revolution, including augmented reality (AR), virtual reality (VR), Internet of Things (IoTs), and artificial intelligence (AI). There has been a great demand for a novel technology for better, user-oriented exhibition services. The NSM continuously faces the problem of not having enough professional guides. Additionally, there have been constant complaints about its current mobile application for exhibitions not being very effective. To tackle these problems, the new center was founded, involving 11 institutes and universities. Sponsored by the National Research Foundation, it will oversee 15 projects in three areas: exhibition-based technology, exhibition operational technology, and exhibition content. The group first aims to provide a location-based exhibition guide system service, which allows it to incorporate various technological services, such as AR/VR to visitors. An indoor locating system named KAILOS, which was developed by KAIST, will be applied to this service. They will also launch a mobile application service that provides audio-based exhibition guides. To further cater to visitors’ needs, the group plans to apply a user-centered ecosystem, a living lab concept to create pleasant environment for visitors. “Every year, hundred thousands of young people visit the National Science Museum. I believe that the exhibition guide system has to be innovative, using cutting-edge IT technology in order to help them cherish their dreams and inspirations through science,” Jeong Heoi Bae, President of Exhibition and Research Bureau of NSM, emphasized. Professor Dong Soo Han from the School of Computing, who took the position of research head of the group, said, “We will systematically develop exhibition technology and contents for the science museum to create a platform for smart science museums. It will be the first time to provide an exhibition guide system that integrates AR/VR with an indoor location system.” The center will first apply the new system to the NSM and then expand it to 167 science museums and other regional museums.
2018.09.04
View 7318
Participation in the 2018 Bio-Digital City Workshop in Paris
(A student make a presentatiion during the Bio-Digital City Workshop in Paris last month.) KAIST students explored ideas for developing future cities during the 2018 Bio-Digital City Workshop held in Paris last month. This international workshop hosted by Cité des Sciences et de l'Industrie was held under the theme “Biomimicry, Digital City and Big Data.” During the workshop from July 10 to July 20, students teamed up with French counterparts to develop innovative urban design ideas. Cité des Sciences et de l'Industrie is the largest science museum in Europe and is operated by Universcience, a specialized institute of science and technology in France. Professor Seongju Chang from the Department of Civil and Environmental Engineering and Professor Jihyun Lee of the Graduate School of Culture Technology Students led the students group. Participants presented their ideas and findings on new urban solutions that combine biomimetic systems and digital technology. Each student group analyzed a special natural ecosystem such as sand dunes, jellyfish communities, or mangrove forests and conducted research to extract algorithms for constructing sustainable urban building complexes based on the results. The extracted algorithm was used to conceive a sustainable building complex forming a part of the urban environment by applying it to the actual Parisian city segment given as the virtual site for the workshop. Students from diverse background in both countries participated in this convergence workshop. KAIST students included Ph.D. candidate Hyung Min Cho, undergraduates Min-Woo Jeong, Seung-Hwan Cha, and Sang-Jun Park from the Department of Civil and Environmental Engineering, undergraduate Kyeong-Keun Seo from the Department of Materials Science and Engineering, JiWhan Jeong (Master’s course) from the Department of Industrial and Systems Engineering, Ph.D. candidate Bo-Yoon Zang from the Graduate School of Culture Technology. They teamed up with French students from diverse backgrounds, including Design/Science, Visual Design, Geography, Computer Science and Humanities and Social Science. This workshop will serve as another opportunity to expand academic and human exchange efforts in the domain of smart and sustainable cities with Europe in the future as the first international cooperation activity of KAIST and the Paris La Villette Science Museum. Professor Seong-Ju Chang who led the research group said, "We will continue to establish a cooperative relationship between KAIST and the European scientific community. This workshop is a good opportunity to demonstrate the competence of KAIST students and their scientific and technological excellence on the international stage.”
2018.08.01
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Photonic Capsules for Injectable Laser Resonators
A KAIST research group presented photonic capsules for injectable laser resonators using microfluidic technology. The capsule’s diameter is comparable to a human hair and stable in gas and liquid media, so it is injectable into any target volume. The research group headed by Professor Shin-Hyun Kim in the Department of Chemical and Biomolecular Engineering applied an interesting optical property from nature. Professor Kim, who has dived deep into photonic materials research inspired from nature such as the Morpho butterfly, used a trait of beetles this time. Chrysina gloriosa, commonly known as the glorious beetle, shows a green color similar to leaves when illuminated by left-handed, circularly-polarized light while showing no color with right-handed, circularly-polarized light. This unique optical feature helps the beetles communicate with each other and protects them from predators. The principle behind this interesting optical property of the beetles relies on helical nanostructures with left-handedness that are present on the shell of the beetles. The helical structures reflect a circularly-polarized light with the same handedness of the helix at the wavelength selected by the helical pitch through optical interference. Such helical nanostructures can be artificially created using liquid crystals (LCs). LCs with a helical arrangement are referred to as cholesteric LCs (CLCs). The CLCs exhibit the polarization-dependent reflection of light in the same manner as the beetles and have been used for various photonic applications. In particular, CLCs have been cast to a film format that serves as mirrorless laser resonators, unlike conventional lasing systems. However, the film-type CLCs are large in size and show unidirectional emission, which restricts the use of CLC resonators in microenvironments. To overcome these limitations, Professor Kim’s group has encapsulated the CLCs with dual shells using microfluidic technology. The inner shell is a water layer that promotes the alignment of LC molecules and the outer shell is an elastic polymer layer that secures capsule stability and enables reversible mechanical deformation. The spherical symmetry of the capsules enables omnidirectional laser emissions. Moreover, laser intensity and lasing direction can be further controlled by deforming the capsules, while its wavelength remains tunable. This new type of CLC laser resonator is promising for laser treatments in various biomedical applications. Professor Kim said, “The helical nanostructure used in the laser resonator resembles that of the shell of chrysina gloriosa. Humans learn from nature and engineer materials to create something unprecedented.” This research was led by graduate student Sang Seok Lee and an article entitled “Wavelength-tunable and shape-reconfigurable photonic capsule resonators containing cholesteric liquid crystals” was published online on June 22, in Science Advances. Figure 1. Chrysina gloriosa illuminated by left-handed (left panel) and right-handed (right panel) circularly-polarized lights. (Image source: https://doi.org/10.1016/j.cub.2010.05.036 , permitted for reuse in news media) Figure 2. Composition (left panel) and optical microscopy image (right panel) of the capsule-type laser resonator
2018.07.05
View 8576
Professor Suh Chosen for IT Young Engineer Award
(The ceremony photo of Professor Changho Suh) Professor Changho Suh from the School of Electrical Engineering received the IT Young Engineer Award on June 28. This award is hosted by the Institute of Electrical and Electronics Engineers (IEEE) and the Institute of Electrical and Information Engineers (IEIE) and funded by the Haedong Science Foundation. The IT Young Engineer Award is given to researchers under the age of 40 in Korea. The selection criteria include the researches’ technical practicability, their social and environmental contributions, and their creativity. Professor Suh has shown outstanding academic performance in the field of telecommunications, distributed storage, and artificial intelligence and he has also contributed to technological commercialization. He published 23 papers in SCI journals and ten papers at top-level international conferences including the Conference on Neural Information Processing Systems and the International Conference on Machine Learning. His papers were cited more than 4,100 times. He has also achieved 30 international patent registrations. Currently, he is developing an autonomous driving system using an AI-tutor and deep learning technology. Professor Suh said, “It is my great honor to receive the IT Young Engineer Award. I strive to continue guiding students and carrying out research in order to make a contribution to the fields of IT and AI.”
2018.07.04
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Taming AI: Engineering, Ethics, and Policy
(Professor Lee, Professor Koene, Professor Walsh, and Professor Ema (from left)) Can AI-powered robotics could be adequate companions for humans? Will the good faith of users and developers work for helping AI-powered robots become the new tribe of the digital future? AI’s efficiency is creating new socio-economic opportunities in the global market. Despite the opportunities, challenges still remain. It is said that efficiency-enforcing algorithms through deep learning will take an eventual toll on human dignity and safety, bringing out the disastrous fiascos featured in the Terminator movies. A research group at the Korean Flagship AI Project for Emotional Digital Companionship at KAIST Institute for AI (KI4AI) and the Fourth Industrial Intelligence Center at KAIST Institute co-hosted a seminar, “Taming AI: Engineering, Ethics, and Policy” last week to discuss ways to better employ AI technologies in ways that upholds human values. The KI4AI has been conducting this flagship project from the end of 2016 with the support of the Ministry of Science and ICT. The seminar brought together three speakers from Australia, Japan, and the UK to better fathom the implications of the new technology emergence from the ethical perspectives of engineering and discuss policymaking for the responsible usage of technology. Professor Toby Walsh, an anti-autonomous weapon activist from New South Wales University in Australia continued to argue the possible risk that AI poses to malfunction. He said that an independent ethics committee or group usually monitors academic institutions’ research activities in order to avoid any possible mishaps. However, he said there is no independent group or committee monitoring the nature of corporations’ engagement of such technologies, while its possible threats against humanity are alleged to be growing. He mentioned that Google’s and Amazon’s information collecting also pose a potent threat. He said that ethical standards similar to academic research integrity should be established to avoid the possible restricting of the dignity of humans and mass destruction. He hoped that KAIST and Google would play a leading role in establishing an international norm toward this compelling issue. Professor Arisa Ema from the University of Tokyo provided very compelling arguments for thinking about the duplicity of technology and how technology should serve the public interest without any bias against gender, race, and social stratum. She pointed out the information dominated by several Western corporations like Google. She said that such algorithms for deep learning of data provided by several Western corporations will create very biased information, only applicable to limited races and classes. Meanwhile, Professor Ansgar Koene from the University of Nottingham presented the IEEE’s global initiative on the ethics of autonomous and intelligence systems. He shared the cases of industry standards and ethically-aligned designs made by the IEEE Standards Association. He said more than 250 global cross-disciplinary thought leaders from around the world joined to develop ethical guidelines called Ethically Aligned Design (EAD) V2. EAD V2 includes methodologies to guide ethical research and design, embedding values into autonomous intelligence systems among others. For the next step beyond EAD V2, the association is now working for IEEE P70xx Standards Projects, detailing more technical approaches. Professor Soo Young Lee at KAIST argued that the eventual goal of complete AI is to have human-like emotions, calling it a new paradigm for the relationship between humans and AI-robots. According to Professor Lee, AI-powered robots will serve as a good companion for humans. “Especially in aging societies affecting the globe, this will be a very viable and practical option,” he said. He pointed out, “Kids learn from parents’ morality and social behavior. Users should have AI-robots learn morality as well. Their relationships should be based on good faith and trust, no longer that of master and slave. He said that liability issues for any mishap will need to be discussed further, but basically each user and developer should have their own responsibility when dealing with these issues.
2018.06.26
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Distinguished Professor Koh Donates His Ho-Am Prize Money
(From left: Distinguished Professor Gou Young Koh and KAIST President Sung-Chul Shin) Distinguished Professor Gou Young Koh from the Graduate School of Medical Science and Engineering donated one hundred million KRW to KAIST that he received for winning the Ho-Am Prize. Professor Koh, who is widely renowned for angiogenesis, was appointed as the 2018 laureate of the 28th Ho-Am Prize for demonstrating the effective reduction of tumor progression and metastasis via tumor vessel normalization. He made the donation to the Graduate School of Medical Science and Engineering, where he conducted his research. “As a basic medical scientist, it is my great honor to receive this prize for the recognition of my research outcome. I will give impetus to research for continuous development,” Professor Koh said. Professor Koh also received the 5th Asan Award in Medicine in 2012 and the 7th Kyung-Ahm Award in 2011. He was also the awardee of the 17th Wunsch Medical Award. He has donated cash prizes to the school every time he is awarded. KAIST President Sung-Chul Shin said, “I would like to express my gratitude to the professor for his generous donation to the school. It will be a great help fostering outstanding medical scientists. Professor Koh received his MD-PhD from the Medical School of Chonbuk National University. After finishing his post-doctoral program at Cornell University and Indiana State University, he was appointed as a professor at Chonbuk National University and POSTECH. Currently, he holds the position of distinguished professor at KAIST and director of the IBS Center for Vascular Research.
2018.06.20
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KAIST Team Reaching Out with Appropriate Technology
(The gold prize winning team of KATT) The KAIST Appropriate Technology Team (KATT) consisting of international students at KAIST won the gold and silver prizes at ‘The 10th Creative Design Competition for the Other 90 Percent.’ More than 218 students from 50 teams nationwide participated in the competition hosted by the Ministry of Science and ICT last month. The competition was created to discover appropriate technology and sustainable design items to enhance the quality of life for those with no or few accessible technologies. A team led by Juan Luis Gonzalez Bello, graduate student from the School of Electrical Engineering received the gold prize for presenting a prosthetic arm. Their artificial arm was highly recognized for its affordability and good manageability. The team said that it cost less than 10 US dollars to construct from materials available in underprivileged regions and was easy to assemble. Sophomore Hutomo Calvin from the Department of Materials Science & Engineering also worked on the prosthetic arm project with freshmen Bella Godiva, Stephanie Tan, and Koptieuov Yearbola. Alexandra Tran, senior from the School of Electrical Engineering led the silver prize winning team. Her team developed a portable weather monitor, ‘Breathe Easy’. She worked with Alisher Tortay, senior from the School of Computing, Ashar Alam, senior from the Department of Mechanical Engineering, Bereket Eshete, junior from the School of Computing, and Marthens Hakzimana, sophomore from the Department of Mechanical Engineering. This weather monitor is a low-cost but efficient air quality monitor. The team said it just cost less than seven US dollars to construct the monitor.KAIST students have now won the gold prize for two consecutive years.
2018.06.19
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KAISTians Receive Future Ocean Science and Technology Awards
(From left: PhD candidates Minseok Kang and Junkeon Ahn) PhD candidates Minseok Kang and Junkeon Ahn from the Department of Mechanical Engineering received Future Ocean Science and Technology Awards from the Korean Association of Ocean Science and Technology Societies (KAOSTS). Since 2017, KAOSTS has conferred this award upon graduate students who have published outstanding papers on ocean science and technology in order to encourage young researchers in this area. Kang published ‘Ship block assembly sequence planning considering productivity and welding deformation’ in Naval Architecture and Ocean Engineering in which he proposed an assembly sequence planning method for block assemblies that considers the geometric characteristics of blocks to determine feasible assembly sequences as well as assembly process and productivity factors. Ahn published ‘Fuzzy-based FMEA of hybrid MCFC and gas turbine system for marine propulsion’ in Power Sources. In this research, he conducted a study proposing a fuzzy-based failure mode and effect analysis (FMEA) for a hybrid molten carbonate fuel cell and gas turbine system for liquefied hydrogen tankers.
2018.06.15
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The Center for Anthropocene Studies (CAS) Opens
KAIST will start Anthropocene research, a convergence field of study, to address issues related to the commencement of human activities that have had scientific, industrial, and economic impacts on the Earth’s ecosystem. The National Research Foundation (NRF) of Korea endorsed the KAIST Center for Anthropocene Studies as its Convergence Research Center project. Anthropocene refers to a new geological age in which various polluting materials that humans have made during the post-industrial revolution era have made a significant impact on the Earth and the lives of humankind. The studies expand the diverse socio-economic and environmental sectors for responding to climate change, natural disasters, ecological destruction, the polarization of the inequality and wealth, and many others. The KAIST research group at the center, in collaboration with the Graduate School of Science and Technology Policy, the Graduate School of Culture Technology, the School of Humanities & Social Sciences, the Department of Industrial Design, the School of Electrical Engineering, the Satellite Technology Research Center (SaRTec), and the KAIST Initiative for Disaster Studies will conduct multidisciplinary research to address intriguing challenges with complex but creative approaches incorporating the fields of engineering, socioeconomics, and art. The group will investigate topics such as▲ surface and marine changes to the Earth by applying satellite data ▲disaster prediction and governance system building through AI modeling ▲sustainable housing, transportation, and lifestyles ▲ engineering and artistic approaches for envisioning a new future for humankind and the Earth. Professor Buhm Soon Park, who is in charge of the center, said, “This pioneering research work will inspire the re-creation of a new paradigm of convergence studies in science, engineering, humanities, and social science. We will contribute to making the world better by designing new technologies and social policies.
2018.06.05
View 9792
Recombinant E. Coli As a Biofactory for the Biosynthesis of Diverse Nanomaterials
(Distinguished Professor Lee and PhD candidate Choi) A metabolic research group at KAIST and Chung-Ang University in Korea has developed a recombinant E. coli strain that biosynthesizes 60 different nanomaterials covering 35 elements on the periodic table. Among the elements, the team could biosynthesize 33 novel nanomaterials for the first time, advancing the forward design of nanomaterials through the biosynthesis of various single and multi-elements. The study analyzed the nanomaterial biosynthesis conditions using a Pourbaix diagram to predict the producibility and crystallinity. Researchers studied a Pourbaix diagram to predict the stable chemical species of each element for nanomaterial biosynthesis at varying levels of reduction potential (Eh) and pH. Based on the Pourbaix diagram analyses, the initial pH of the reaction was changed from 6.5 to 7.5, resulting in the biosynthesis of various crystalline nanomaterials that were previously amorphous or not synthesized. This strategy was extended to biosynthesize multi-element nanomaterials. Various single and multi-element nanomaterials biosynthesized in this research can potentially serve as new and novel nanomaterials for industrial applications such as catalysts, chemical sensors, biosensors, bioimaging, drug delivery, and cancer therapy. A research group consisting of PhD candidate Yoojin Choi, Associate Professor Doh Chang Lee, and Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering at KAIST and Associate Professor Tae Jung Park of the Department of Chemistry at Chung-Ang University reported the synthesis. This study, entitled “Recombinant Escherichia coli as a biofactory for various single- and multi-element nanomaterials,” was published online in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) on May 21. A recent successful biosynthesis of nanomaterials under mild conditions without requiring physical and chemical treatments has triggered the exploration of the full biosynthesis capacity of a biological system for producing a diverse range of nanomaterials as well as for understanding biosynthesis mechanisms for crystalline versus amorphous nanomaterials. There has been increased interest in synthesizing various nanomaterials that have not yet been synthesized for various applications including semiconducting materials, enhanced solar cells, biomedical materials, and many others. This research reports the construction of a recombinant E. coli strain that co-expresses metallothionein, a metal binding protein, and phytochelatin synthase that synthesizes the metal-binding peptide phytochelatin for the biosynthesis of various nanomaterials. Subsequently, an E. coli strain was engineered to produce a diverse range of nanomaterials, including those never biosynthesized before, by using 35 individual elements from the periodic table and also by combining multi-elements. Distinguished Professor Lee said, “An environmentally-friendly and sustainable process is of much interest for producing nanomaterials by not only chemical and physical methods but biological synthesis. Moreover, there has been much attention paid to producing diverse and novel nanomaterials for new industrial applications. This is the first report to predict the biosynthesis of various nanomaterials, by far the largest number of various single- and multi-elements nanomaterials. The strategies used for nanomaterial biosynthesis in this research will be useful for further diversifying the portfolio of nanomaterials that can be manufactured.” Figure: The biosynthesis of diverse nanomaterials using recombinant E. coli. This schematic diagram shows the overall conceptualization of the biosynthesis of various single and multi-element nanomaterials using recombinant E. coli under incubation with corresponding elemental precursors. The 35 elements that were tested to biosynthesize nanomaterials are shown in black circles on the periodic table.
2018.05.23
View 10316
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