Research
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Formosa Group of Taiwan to Establish Bio R&D Center at KAIST Investing 12.5 M USD
KAIST (President Kwang-Hyung Lee) announced on February 17th that it signed an agreement for cooperation in the bio-medical field with Formosa Group, one of the three largest companies in Taiwan.
< Formosa Group Chairman Sandy Wang and KAIST President Kwang-Hyung Lee at the signing ceremony >
Formosa Group Executive Committee member and Chairman Sandy Wang, who leads the group's bio and eco-friendly energy sectors, decided to establish a bio-medical research center within KAIST and invest approximately KRW 18 billion or more over 5 years. In addition, to commercialize the research results, KAIST and Formosa Group will establish a joint venture in Korea with KAIST Holdings, a KAIST-funded company.
The cooperation between the two organizations began in early 2023 when KAIST signed a comprehensive exchange and cooperation agreement (MOU) with Ming Chi University of Science and Technology (明志科技大學), Chang Gung University (長庚大學), and Chang Gung Memorial Hospital (長庚記念醫院), which are established and supported by Formosa Group. Afterwards, Chairman Sandy Wang visited KAIST in May 2024 and signed a more specific business agreement (MOA).
KAIST Holdings is a holding company established by KAIST, a government-funded organization, to attract investment and conduct business, and will pursue the establishment of a joint venture with a 50:50 equity structure in cooperation with Formosa Group. KAIST Holdings will invest KAIST’s intellectual property rights, and Formosa Group will invest a corresponding amount of funds.
The KAIST-Formosa joint venture will provide research funds to the KAIST-Formosa Bio-Medical Research Center to be established in the future, secure the right to implement the intellectual property rights generated, and promote full-scale business.
The KAIST-Formosa Bio-Medical Research Center will establish a ‘brain organoid bank’ created by obtaining tissues from hundreds of patients with degenerative brain diseases, thereby securing high-dimensional data that will reveal the fundamental causes of aging and disease. It is expected that KAIST’s world-class artificial intelligence technology will analyze large-scale patient data to find the causes of aging and disease.
Through this business, it is expected that by 2030, five years from now, it will discover more than 10 types of intractable brain disease treatments and expand to more than 20 businesses, including human cell-centered diagnostics and preclinical businesses, and secure infrastructure and intellectual property rights that can create value worth approximately KRW 250 billion.
The Chang Gung Memorial Hospital in Taiwan has 10,000 beds and handles 35,000 patients per day, and systematically accumulates patient tissue and clinical data. Chang Gung Memorial Hospital will differentiate the tissues of patients with degenerative brain diseases and send them to the KAIST-Formosa Bio-Medical Research Center, which will then produce brain organoids to be used for disease research and new drug development. This will allow the world’s largest patient tissue data bank to be established.
Dean Daesoo Kim of the College of Life Science and Bioengineering at KAIST said, “This collaboration between KAIST and Formosa Group is a new research collaboration model that goes beyond joint research to establish a joint venture and global commercialization of developed technologies, and it is significant in that it can serve as an opportunity to promote biomedical research and development.”
With this agreement, KAIST, which has been promoting the KAIST Advanced Regenerative Medicine Engineering Center in Osong K-Bio Square, has secured a practical global partner.
< Representatives of the Formosa Group and KAIST >
KAIST’s Senior Vice President for Planning and Budget, Professor Kyung-Soo Kim emphasized, “KAIST has made great efforts to secure an edge in state-of-the-art biomedical fields such as stem cells and gene editing technology, by attracting the world’s best experts and discovering global cooperation partners, and these results can ultimately be linked to the Osong K-Bio Square project.”
SVP Kim then predicted, “In particular, the practical cooperation with Taiwan’s best Formosa Chang Gung Memorial Hospital, which has abundant clinical experience in stem cell treatment, will be an important axis of KAIST’s bio innovation strategy.”
Formosa Chairman Sandy Wang emphasized that this investment and cooperation is built on trust in KAIST’s R&D capabilities and the passion of its researchers. And added that through this, the Formosa Group will practice corporate social responsibility and take an important first step together with KAIST to protect the welfare and health of humanity. She also went on the say that she expects to see the cooperation expanded to various fields such as mobility and semiconductors based on the successes begotten from the cooperation in the bio field.
KAIST President Kwang-Hyung Lee said, “I evaluate this agreement as one of the most important events that will spearhead KAIST into overseas biotechnology stages,” and added, “I expect that this cooperation will be an opportunity for Taiwan and Korea, both of which have IT industry-centered structures, to create new growth engines in the bio industry.” Meanwhile, Formosa Group is a company founded by Chairman Sandy Wang’s father, Chairman Yung-Ching Wang. It is the world’s No. 1 plastic PVC producer and is leading core industries of the Taiwanese economy, including semiconductors, steel, heavy industry, bio, and batteries. Chairman Yung-Ching Wang was respected by the Taiwanese people for his exemplary return of wealth to society under the belief that the companies and assets he founded “belong to the people.”
2025.02.17 View 1319 -
KAIST Develops Wearable Carbon Dioxide Sensor to Enable Real-time Apnea Diagnosis
- Professor Seunghyup Yoo’s research team of the School of Electrical Engineering developed an ultralow-power carbon dioxide (CO2) sensor using a flexible and thin organic photodiode, and succeeded in real-time breathing monitoring by attaching it to a commercial mask
- Wearable devices with features such as low power, high stability, and flexibility can be utilized for early diagnosis of various diseases such as chronic obstructive pulmonary disease and sleep apnea
< Photo 1. From the left, School of Electrical Engineering, Ph.D. candidate DongHo Choi, Professor Seunghyup Yoo, and Department of Materials Science and Engineering, Bachelor’s candidate MinJae Kim >
Carbon dioxide (CO2) is a major respiratory metabolite, and continuous monitoring of CO2 concentration in exhaled breath is not only an important indicator for early detection and diagnosis of respiratory and circulatory system diseases, but can also be widely used for monitoring personal exercise status. KAIST researchers succeeded in accurately measuring CO2 concentration by attaching it to the inside of a mask.
KAIST (President Kwang-Hyung Lee) announced on February 10th that Professor Seunghyup Yoo's research team in the Department of Electrical and Electronic Engineering developed a low-power, high-speed wearable CO2 sensor capable of stable breathing monitoring in real time.
Existing non-invasive CO2 sensors had limitations in that they were large in size and consumed high power. In particular, optochemical CO2 sensors using fluorescent molecules have the advantage of being miniaturized and lightweight, but due to the photodegradation phenomenon of dye molecules, they are difficult to use stably for a long time, which limits their use as wearable healthcare sensors.
Optochemical CO2 sensors utilize the fact that the intensity of fluorescence emitted from fluorescent molecules decreases depending on the concentration of CO2, and it is important to effectively detect changes in fluorescence light.
To this end, the research team developed a low-power CO2 sensor consisting of an LED and an organic photodiode surrounding it. Based on high light collection efficiency, the sensor, which minimizes the amount of excitation light irradiated on fluorescent molecules, achieved a device power consumption of 171 μW, which is tens of times lower than existing sensors that consume several mW.
< Figure 1. Structure and operating principle of the developed optochemical carbon dioxide (CO2) sensor. Light emitted from the LED is converted into fluorescence through the fluorescent film, reflected from the light scattering layer, and incident on the organic photodiode. CO2 reacts with a small amount of water inside the fluorescent film to form carbonic acid (H2CO3), which increases the concentration of hydrogen ions (H+), and the fluorescence intensity due to 470 nm excitation light decreases. The circular organic photodiode with high light collection efficiency effectively detects changes in fluorescence intensity, lowers the power required light up the LED, and reduces light-induced deterioration. >
The research team also elucidated the photodegradation path of fluorescent molecules used in CO2 sensors, revealed the cause of the increase in error over time in photochemical sensors, and suggested an optical design method to suppress the occurrence of errors.
Based on this, the research team developed a sensor that effectively reduces errors caused by photodegradation, which was a chronic problem of existing photochemical sensors, and can be used continuously for up to 9 hours while existing technologies based on the same material can be used for less than 20 minutes, and can be used multiple times when replacing the CO2 detection fluorescent film.
< Figure 2. Wearable smart mask and real-time breathing monitoring. The fabricated sensor module consists of four elements (①: gas-permeable light-scattering layer, ②: color filter and organic photodiode, ③: light-emitting diode, ④: CO2-detecting fluorescent film). The thin and light sensor (D1: 400 nm, D2: 470 nm) is attached to the inside of the mask to monitor the wearer's breathing in real time. >
The developed sensor accurately measured CO2 concentration by being attached to the inside of a mask based on the advantages of being light (0.12 g), thin (0.7 mm), and flexible. In addition, it showed fast speed and high resolution that can monitor respiratory rate by distinguishing between inhalation and exhalation in real time.
< Photo 2. The developed sensor attached to the inside of the mask >
Professor Seunghyup Yoo said, "The developed sensor has excellent characteristics such as low power, high stability, and flexibility, so it can be widely applied to wearable devices, and can be used for the early diagnosis of various diseases such as hypercapnia, chronic obstructive pulmonary disease, and sleep apnea." He added, "In particular, it is expected to be used to improve side effects caused by rebreathing in environments where dust is generated or where masks are worn for long periods of time, such as during seasonal changes."
This study, in which KAIST's Department of Materials Science and Engineering's undergraduate student Minjae Kim and School of Electrical Engineering's doctoral student Dongho Choi participated as joint first authors, was published in the online version of Cell's sister journal, Device, on the 22nd of last month. (Paper title: Ultralow-power carbon dioxide sensor for real-time breath monitoring) DOI: https://doi.org/10.1016/j.device.2024.100681
< Photo 3. From the left, Professor Seunghyup Yoo of the School of Electrical Engineering, MinJae Kim, an undergraduate student in the Department of Materials Science and Engineering, and Dongho Choi, a doctoral student in the School of Electrical Engineering >
This study was supported by the Ministry of Trade, Industry and Energy's Materials and Components Technology Development Project, the National Research Foundation of Korea's Original Technology Development Project, and the KAIST Undergraduate Research Participation Project. This work was supported by the (URP) program.
2025.02.13 View 2472 -
KAIST Uncovers the Principles of Gene Expression Regulation in Cancer and Cellular Functions
< (From left) Professor Seyun Kim, Professor Gwangrog Lee, Dr. Hyoungjoon Ahn, Dr. Jeongmin Yu, Professor Won-Ki Cho, and (below) PhD candidate Kwangmin Ryu of the Department of Biological Sciences>
A research team at KAIST has identified the core gene expression networks regulated by key proteins that fundamentally drive phenomena such as cancer development, metastasis, tissue differentiation from stem cells, and neural activation processes. This discovery lays the foundation for developing innovative therapeutic technologies.
On the 22nd of January, KAIST (represented by President Kwang Hyung Lee) announced that the joint research team led by Professors Seyun Kim, Gwangrog Lee, and Won-Ki Cho from the Department of Biological Sciences had uncovered essential mechanisms controlling gene expression in animal cells.
Inositol phosphate metabolites produced by inositol metabolism enzymes serve as vital secondary messengers in eukaryotic cell signaling systems and are broadly implicated in cancer, obesity, diabetes, and neurological disorders.
The research team demonstrated that the inositol polyphosphate multikinase (IPMK) enzyme, a key player in the inositol metabolism system, acts as a critical transcriptional activator within the core gene expression networks of animal cells. Notably, although IPMK was previously reported to play an important role in the transcription process governed by serum response factor (SRF), a representative transcription factor in animal cells, the precise mechanism of its action was unclear.
SRF is a transcription factor directly controlling the expression of at least 200–300 genes, regulating cell growth, proliferation, apoptosis, and motility, and is indispensable for organ development, such as in the heart.
The team discovered that IPMK binds directly to SRF, altering the three-dimensional structure of the SRF protein. This interaction facilitates the transcriptional activity of various genes through the SRF activated by IPMK, demonstrating that IPMK acts as a critical regulatory switch to enhance SRF's protein activity.
< Figure 1. The serum response factor (SRF) protein, a key transcription factor in animal cells, directly binds to inositol polyphosphate multikinase (IPMK) enzyme and undergoes structural change to acquire DNA binding ability, and precisely regulates growth and differentiation of animal cells through transcriptional activation. >
The team further verified that disruptions in the direct interaction between IPMK and SRF lead to the reduced functionality and activity of SRF, causing severe impairments in gene expression.
By highlighting the significance of the intrinsically disordered region (IDR) in SRF, the researchers underscored the biological importance of intrinsically disordered proteins (IDPs). Unlike most proteins that adopt distinct structures through folding, IDPs, including those with IDRs, do not exhibit specific structures but play crucial biological roles, attracting significant attention in the scientific community.
Professor Seyun Kim commented, "This study provides a vital mechanism proving that IPMK, a key enzyme in the inositol metabolism system, is a major transcriptional activator in the core gene expression network of animal cells. By understanding fundamental processes such as cancer development and metastasis, tissue differentiation from stem cells, and neural activation through SRF, we hope this discovery will lead to the broad application of innovative therapeutic technologies."
The findings were published on January 7th in the international journal Nucleic Acids Research (IF=16.7, top 1.8% in Biochemistry and Molecular Biology), under the title “Single-molecule analysis reveals that IPMK enhances the DNA-binding activity of the transcription factor SRF" (DOI: 10.1093/nar/gkae1281).
This research was supported by the National Research Foundation of Korea's Mid-career Research Program, Leading Research Center Program, and Global Research Laboratory Program, as well as by the Suh Kyungbae Science Foundation and the Samsung Future Technology Development Program.
2025.01.24 View 6357 -
KAIST Opens Newly Expanded Center for Contemplative Research in Collaboration with Brain and Cognitive Sciences Department
KAIST (represented by President Kwang Hyung Lee) announced on January 2nd that it would hold an opening ceremony for the expanded KAIST Center for Contemplative Research (Director Wan Doo Kim) at the Creativity Learning Building on its Daejeon campus on January 3 (Friday).
Established in 2018 with the mission of "integrating meditation and science for the happiness and prosperity of humanity," the KAIST Center for Contemplative Research has been expanding its scope of research into the neuroscience of meditation and training empathetic educators who will lead the field of meditation science in collaboration with the Brain and Cognitive Sciences Department, which was established in 2022.
Supported by the Plato Academy Foundation and with funding from SK Discovery for the facility’s expansion, the center now occupies an extended space on the 5th floor of the Creativity Learning Center. The new facilities include: ▲ Advanced Research Equipment ▲ Meditation Science Laboratories ▲ VR/XR-Based Meditation Experience Rooms ▲ A Large Digital Art Meditation Hall ▲ Personal Meditation Halls.
Particularly, the center plans to conduct next-generation meditation research using cutting-edge technologies such as: ▲ Brain-Computer Interface Technology ▲ Meditation Wearable Devices ▲ Metaverse-Based Meditation Environments.
The opening ceremony, scheduled for the morning of January 3 (Friday), was attended by key figures, including Plato Academy Foundation Chairman Chang-Won Choi, MindLab CEO Professor Seong-Taek Cho, Bosung Group Vice President Byung-Chul Lee, and KAIST President Kwang Hyung Lee.
The event began with a national moment of silence to honor the victims of the recent Jeju Air passenger accident. It included a progress report by the center director, a lecture by Professor Jaeseung Jeong, panel discussions, and more.
Following a tour of the expanded facilities, the center hosted a 20-minute hands-on meditation science session using *Looxid Labs EEG devices for the first 50 participants.
*Looxid Labs EEG Device: A real-time brainwave measurement device developed by KAIST startup Looxid Labs that enables users to experience efficient and AI-powered data-driven meditation science practice (Looxid Labs website: https://looxidlabs.com/).
During the ceremony, Director of the Center for Contemplative Research Wan Doo Kim presented on "The Mission, Vision, and Future of the KAIST Center for Contemplative Research." Yujin Lee, a combined master’s and doctoral researcher from the Brain and Cognitive Sciences Department, shared insights on "The Latest Trends in Meditation Science Research."
A panel discussion and Q&A session on "The Convergence of Meditation and Brain and Cognitive Sciences" followed featuring Professors Jaeseung Jeong, HyungDong Park (Brain and Cognitive Sciences), and Jiyoung Park (Digital Humanities and Social Sciences).
Director Wan Doo Kim commented, “With this expanded opening, we aim to offer advanced meditation programs integrating brain and cognitive sciences and cutting-edge technology not only to KAIST members but also to the general public interested in meditation. We will continue to dedicate ourselves to interdisciplinary research between meditation and science.”
2025.01.03 View 1589 -
KAIST ISSS Research Session Captivates 150↑ International Scholars, Achieve Major Success
< Photo. Scholars gatheres for NRF Information Session at Chung Keun Mo Hall >
KAIST’s International Office, headed by Vice President Soyoung Kim, successfully organized the ‘NRF Information Session for International Scholars’ on September 11, 2024, in collaboration with the National Research Foundation of Korea (NRF).
The event was held at KAIST’s main campus to enourage the international scholar’s active participation in research projects and support their establishment of stable research environment and integration into Korea’s academic community by introducing NRF’s key research programs.
Divided into two main segments – science and engineering, and humanities and social sciences – the session attracted approximately 150 international faculty and researchers from 23 universities across the nation.
The event commenced with a keynote address by Vice President Soyoung Kim, followed by a presentation from Dr. Seol Min of the National Research Foundation, who highlighted basic research initiatives in the science and technology sector. Subsequently, Professor Daniel Martin from the Digital Humanities and Social Sciences Department and Professor Thomas Steinberger from the Department of Business and Technology Management presented practical research project support case studies, sharing invaluable insights gained from their domestic research experiences.
Following the information session, participants engaged in a networking event, where researchers involved in major R&D projects exchanged insights and discussed their ongoing research initiatives.
An international professor remarked, “My understanding of NRF’s research programs for international researchers has broadened considerably. I am now more inclined to actively participate in projects organized by NRF in the future.”
Vice President Kim expressed her aspiration that the event would address the challenges faced by researchers and offer essential support to those engaged in research projects. “We will stay attuned to the needs of the research community and work towards creating a more supportive research environment,” said the VP.
Meanwhile, KAIST hosts a distinguished faculty comprising 134 professors from 22 countries and 71 researchers representing 23 nations, all contributing to groundbreaking academic achievements. Additionally, KAIST is home to over 1,000 international students from more than 100 countries, actively pursuing their studies. This diverse composition of global talent reinforces KAIST's position as a leading international hub for research and education.
2024.09.13 View 2914 -
KAIST and Merck Sign MOU to Boost Biotech Innovation
< (From left) KAIST President Kwang-Hyung Lee and Merck CEO Matthias Heinzel >
KAIST (President Kwang-Hyung Lee) signed a Memorandum of Understanding (MOU) with Merck Life Science (CEO Matthias Heinzel) on May 29 to foster innovation and technology creation in advanced biotechnology.
Since May of last year, the two institutions have been discussing multidimensional innovation programs and will now focus on industry-academia cooperation to tackle bioindustry challenges with this MOU as a foundation.
KAIST will conduct joint research projects in various advanced biotechnology fields, such as synthetic biology, mRNA, cell line engineering, and organoids, using the chemical and biological portfolios provided by Merck.
Additionally, KAIST will establish an Experience Lab in collaboration with the Department of Materials Science and Engineering and the Graduate School of Medical Science and Engineering. This lab will support the discovery and analysis of candidate substances in materials science and biology.
Programs to enhance researchers' capabilities will also be offered. Scholarships for graduate students and awards for professors will be implemented. Researchers will have opportunities to participate in global academic events and educational programs hosted by Merck, such as the Curious 2024 Future Insight Conference and the Innovation Cup.
M Ventures, a venture capital subsidiary of Merck Group, will collaborate with KAIST's startup institute to support technology commercialization and continue to develop their startup ecosystem.
The signing ceremony at KAIST's main campus in Daejeon was attended by the CEO of Merck Life Science and the President of KAIST along with representatives from both institutions.
Matthias Heinzel, a member of the Executive Board of Merck and CEO Life Science, said, “This agreement with KAIST is a significant step toward accelerating the development of the life science industry both in Korea and globally. Advancing life science research and fostering the next generation of scientists is essential for discovering new medicines to meet global health needs.”
President Kwang-Hyung Lee responded, “We are pleased to share a vision for scientific advancement with Merck, a leading global technology company. We anticipate that this partnership will strengthen the connection between Merck’s life science business and the global scientific community.”
In March, Merck, a global science and technology company with over 350 years of history, announced a plan to invest 430 billion KRW (€300 million) to build a bioprocessing center in Daejeon, where KAIST is located. This is Merck's largest investment in the Asia-Pacific region.
2024.05.30 View 4961 -
KAIST holds its first ‘KAIST Tech Fair’ in New York, USA
< Photo 1. 2023 KAIST Tech Fair in New York >
KAIST (President Kwang-Hyung Lee) announced on the 11th that it will hold the ‘2023 KAIST Tech Fair in New York’ at the Kimmel Center at New York University in Manhattan, USA, on the 22nd of this month. It is an event designed to be the starting point for KAIST to expand its startup ecosystem into the global stage, and it is to attract investments and secure global customers in New York by demonstrating the technological value of KAIST startup companies directly at location.
< Photo 2. President Kwang Hyung Lee at the 2023 KAIST Tech Fair in New York >
KAIST has been holding briefing sessions for technology transfer in Korea every year since 2018, and this year is the first time to hold a tech fair overseas for global companies.
KAIST Institute of Technology Value Creation (Director Sung-Yool Choi) has prepared for this event over the past six months with the Korea International Trade Association (hereinafter KITA, CEO Christopher Koo) to survey customer base and investment companies to conduct market analysis.
Among the companies founded with the technologies developed by the faculty and students of KAIST and their partners, 7 companies were selected to be matched with companies overseas that expressed interests in these technologies. Global multinational companies in the fields of IT, artificial intelligence, environment, logistics, distribution, and retail are participating as demand agencies and are testing the marketability of the start-up's technology as of September.
Daim Research, founded by Professor Young Jae Jang of the Department of Industrial and Systems Engineering, is a company specializing in smart factory automation solutions and is knocking on the door of the global market with a platform technology optimized for automated logistics systems.
< Photo 3. Presentation by Professor Young Jae Jang for DAIM Research >
It is a ‘collaborative intelligence’ solution that maximizes work productivity by having a number of robots used in industrial settings collaborate with one another. The strength of their solution is that logistics robots equipped with AI reinforced learning technology can respond to processes and environmental changes on their own, minimizing maintenance costs and the system can achieve excellent performance even with a small amount of data when it is combined with the digital twin technology the company has developed on its own.
A student startup, ‘Aniai’, is entering the US market, the home of hamburgers, with hamburger patty automation equipments and solutions. This is a robot kitchen startup founded by its CEO Gunpil Hwang, a graduate of KAIST’s School of Electrical Engineering which gathered together the experts in the fields of robot control, design, and artificial intelligence and cognitive technology to develop technology to automatically cook hamburger patties.
At the touch of a button, both sides of the patty are cooked simultaneously for consistent taste and quality according to the set condition. Since it can cook about 200 dishes in an hour, it is attracting attention as a technology that can not only solve manpower shortages but also accelerate the digital transformation of the restaurant industry.
Also, at the tech fair to be held at the Kimmel Center of New York University on the 22nd, the following startups who are currently under market verification in the U.S. will be participating: ▴'TheWaveTalk', which developed a water quality management system that can measure external substances and metal ions by transferring original technology from KAIST; ▴‘VIRNECT’, which helps workers improve their skills by remotely managing industrial sites using XR*; ▴‘Datumo’, a solution that helps process and analyze artificial intelligence big data, ▴‘VESSL AI’, the provider of a solution to eliminate the overhead** of machine learning systems; and ▴ ‘DolbomDream’, which developed an inflatable vest that helps the psychological stability of people with developmental disabilities.
* XR (eXtended Reality): Ultra-realistic technology that enhances immersion by utilizing augmented reality, virtual reality, and mixed reality technologies
** Overhead: Additional time required for stable processing of the program
In addition, two companies (Plasmapp and NotaAI) that are participating in the D-Unicorn program with the support of the Daejeon City and two companies (Enget and ILIAS Biologics) that are receiving support from the Scale Up Tips of the Ministry of SMEs and Startups, three companies (WiPowerOne, IDK Lab, and Artificial Photosynthesis Lab) that are continuing to realize the sustainable development goals for a total of 14 KAIST startups, will hold a corporate information session with about 100 invited guests from global companies and venture capital.
< Photo 4. Presentation for AP Lab >
Prior to this event, participating startups will be visiting the New York Economic Development Corporation and large law firms to receive advice on U.S. government support programs and on their attemps to enter the U.S. market. In addition, the participating companies plan to visit a startup support investment institution pursuing sustainable development goals and the Leslie eLab, New York University's one-stop startup support space, to lay the foundation for KAIST's leap forward in global technology commercialization.
< Photo 5. Sung-Yool Choi, the Director of KAIST Institute of Technology Value Creation (left) at the 2023 KAIST Tech Fair in New York with the key participants >
Sung-Yool Choi, the Director of KAIST Institute of Technology Value Creation, said, “KAIST prepared this event to realize its vision of being a leading university in creating global value.” He added, “We hope that our startups founded with KAIST technology would successfully completed market verification to be successful in securing global demands and in attracting investments for their endeavors.”
2023.09.11 View 13606 -
MVITRO Co., Ltd. Signs to Donate KRW 1 Billion as Development Fund toward KAIST-NYU Joint Campus
KAIST (President Kwang Hyung Lee) announced on the 29th that it has solicited a development fund of KRW 1 billion from MVITRO (CEO Young Woo Lee) for joint research at the KAIST-NYU Joint Campus, which is being pursued to be KAIST's first campus on the United States.
KAIST plans to use this development fund for research and development of various solutions in the field of 'Healthcare at Home' among several joint researches being conducted with New York University (hereinafter referred to as NYU).
Young Woo Lee, the CEO of MVITRO, said, "We decided to make the donation with the hope that the KAIST-NYU Joint Campus will become an ecosystem that would help with Korean companies’ advancement into the US."
After announcing its plans to enter New York in 2021, KAIST has formed partnerships with NYU and New York City last year. Currently, NYU and KAIST are devising plans for mid- to long-term joint research in nine fields of studies including AI and bio-medicine and technology, and are promoting cooperation in the field of education, including exchange students, minors, double majors, and joint degrees under the joint campus agreement,
The ceremony for the consigning of MVITRO Co., Ltd.’s donation was held at the main campus of KAIST in the afternoon of the 29th and was attended by KAIST officials such as President Kwang Hyung Lee and Jae-Hung Han, the executive director of KAIST Development Foundation, along with the NYU President-Designate Linda G. Mills, and the CEO of MVITRO, Young Woo Lee.
< Photo. (from left) Kwang Hyung Lee, the President of KAIST, Linda G. Mills, the President-Designate of NYU, and Young Woo Lee, the CEO of MVITRO, pose for the photo with the signed letter of donation on May 29, 2023 at KAIST >
Linda Mills, the nominee designated to be NYU president next term said, “I am proud to join our colleagues in celebrating this important gift from MVITRO, which will help support the partnership between KAIST and NYU. This global partnership leverages the distinctive strengths of both universities to drive advances in research poised to deliver profound impact, such as the intersections of healthcare, technology, and AI."
President Kwang Hyung Lee said, "The KAIST-NYU Joint Campus will be the first step in extending KAIST's excellent science and technology capabilities to the international stage and will serve as a bridgehead to help excellent technological advancements venture into the United States." Then, President Lee added, "I would like to express my gratitude to MVITRO for sympathizing with this vision. I will work with NYU to lead the creation of global values.”
On a different note, MVITRO Co., Ltd., is a home medical device maker that collaborated with Hyundai Futurenet Co., Ltd. to develop an IoT product that combined a painless laser lancet (blood collector) and a blood glucose meter into one for a convenient at-home health support, which received favorable reviews from overseas buyers at CES 2023.
2023.05.30 View 7917 -
Yuji Roh Awarded 2022 Microsoft Research PhD Fellowship
KAIST PhD candidate Yuji Roh of the School of Electrical Engineering (advisor: Prof. Steven Euijong Whang) was selected as a recipient of the 2022 Microsoft Research PhD Fellowship.
< KAIST PhD candidate Yuji Roh (advisor: Prof. Steven Euijong Whang) >
The Microsoft Research PhD Fellowship is a scholarship program that recognizes outstanding graduate students for their exceptional and innovative research in areas relevant to computer science and related fields. This year, 36 people from around the world received the fellowship, and Yuji Roh from KAIST EE is the only recipient from universities in Korea. Each selected fellow will receive a $10,000 scholarship and an opportunity to intern at Microsoft under the guidance of an experienced researcher.
Yuji Roh was named a fellow in the field of “Machine Learning” for her outstanding achievements in Trustworthy AI. Her research highlights include designing a state-of-the-art fair training framework using batch selection and developing novel algorithms for both fair and robust training. Her works have been presented at the top machine learning conferences ICML, ICLR, and NeurIPS among others. She also co-presented a tutorial on Trustworthy AI at the top data mining conference ACM SIGKDD. She is currently interning at the NVIDIA Research AI Algorithms Group developing large-scale real-world fair AI frameworks.
The list of fellowship recipients and the interview videos are displayed on the Microsoft webpage and Youtube.
The list of recipients: https://www.microsoft.com/en-us/research/academic-program/phd-fellowship/2022-recipients/
Interview (Global): https://www.youtube.com/watch?v=T4Q-XwOOoJc
Interview (Asia): https://www.youtube.com/watch?v=qwq3R1XU8UE
[Highlighted research achievements by Yuji Roh: Fair batch selection framework]
[Highlighted research achievements by Yuji Roh: Fair and robust training framework]
2022.10.28 View 11623 -
A KAIST Research Team Develops Diesel Reforming Catalyst Enabling Hydrogen Production for Future Mobile Fuel Cells
This catalyst capability allowing stable hydrogen production from commercial diesel is expected to be applied in mobile fuel cell systems in the future hydrogen economy
On August 16, a joint research team led by Professors Joongmyeon Bae and Kang Taek Lee of KAIST’s Department of Mechanical Engineering and Dr. Chan-Woo Lee of Korea Institute of Energy Research (KIER) announced the successful development of a highly active and durable reforming catalyst allowing hydrogen production from commercial diesel.
Fuel reforming is a hydrogen production technique that extracts hydrogen from hydrocarbons through catalytic reactions. Diesel, being a liquid fuel, has a high storage density for hydrogen and is easy to transport and store. There have therefore been continuous research efforts to apply hydrogel supply systems using diesel reformation in mobile fuel cells, such as for auxiliary power in heavy trucks or air-independent propulsion (AIP) systems in submarines.
However, diesel is a mixture of high hydrocarbons including long-chained paraffin, double-bonded olefin, and aromatic hydrocarbons with benzene groups, and it requires a highly active catalyst to effectively break them down. In addition, the catalyst must be extremely durable against caulking and sintering, as they are often the main causes of catalyst degradation. Such challenges have limited the use of diesel reformation technologies to date.
The joint research team successfully developed a highly active and durable diesel reforming catalyst through elution (a heat treatment method used to uniformly grow active metals retained in an oxide support as ions in the form of metal nanoparticles), forming alloy nanoparticles. The design was based on the fact that eluted nanoparticles strongly interact with the support, allowing a high degree of dispersion at high temperatures, and that producing an alloy from dissimilar metals can increase the performance of catalysts through a synergistic effect.
The research team introduced a solution combustion synthesis method to produce a multi-component catalyst with a trace amount of platinum (Pt) and ruthenium (Ru) penetrated into a ceria (CeO2) lattice, which is a structure commonly used as a support for catalysts in redox reactions. When exposed to a diesel reforming reaction environment, the catalyst induces Pt-Ru alloy nanoparticle formation upon Pt and Ru elution onto the support surface.
In addition to the catalyst analysis, the research team also succeeded in characterizing the behaviour of active metal elution and alloy formation from an energetic perspective using a density functional theory-based calculation. In a performance comparison test between the Pt-Ru alloy catalyst against existing single-metal catalysts, the reforming activity was shown to have improved, as it showed a 100% fuel conversion rate even at a low temperature (600oC, compared to the original 800oC). In a long-term durability test (800oC, 200 hours), the catalyst showed commercial stability by successfully producing hydrogen from commercial diesel without performance degradation.
The study was conducted by Ph.D. candidate Jaemyung Lee of KAIST’s Department of Mechanical Engineering as the first author. Ph.D. candidate Changho Yeon of KIER, Dr. Jiwoo Oh of KAIST’s Department of Mechanical Engineering, Dr. Gwangwoo Han of KIER, Ph.D. candidate Jeong Do Yoo of KAIST’s Department of Mechanical Engineering, and Dr. Hyung Joong Yun of the Korea Basic Science Institute contributed as co-authors. Dr. Chan-Woo Lee of KIER and Professors Kang Taek Lee and Joongmyeon Bae of KAIST’s Department of Mechanical Engineering contributed as corresponding authors. The research was published in the online version of Applied Catalysis B: Environmental (IF 24.319, JCR 0.93%) on June 17, under the title “Highly Active and Stable Catalyst with Exsolved PtRu Alloy Nanoparticles for Hydrogen Production via Commercial Diesel Reforming”.
Professor Joongmyeon Bae said, “The fact that hydrogen can be stably produced from commercial diesel makes this a very meaningful achievement, and we look forward to this technology contributing to the active introduction of mobile fuel cell systems in the early hydrogen economy.” He added, “Our approach to catalyst design may be applied not only to reforming reactions, but also in various other fields.”
This research was supported by the National Research Foundation of Korea through funding from the Ministry of Science, ICT and Future Planning.
Figure. Schematic diagram of high-performance diesel reforming catalyst with eluted platinum-ruthenium alloy nanoparticles and long-term durability verification experiment results for commercial diesel reforming reaction
2022.09.07 View 11705 -
KAIST Research Team Proves How a Neurotransmitter may be the Key in Controlling Alzheimer’s Toxicity
With nearly 50 million dementia patients worldwide, and Alzheimers’s disease is the most common neurodegenerative disease. Its main symptom is the impairment of general cognitive abilities, including the ability to speak or to remember. The importance of finding a cure is widely understood with increasingly aging population and the life expectancy being ever-extended. However, even the cause of the grim disease is yet to be given a clear definition.
A KAIST research team in the Department of Chemistry led by professor Mi Hee Lim took on a lead to discovered a new role for somatostatin, a protein-based neurotransmitter, in reducing the toxicity caused in the pathogenic mechanism taken towards development of Alzheimer’s disease. The study was published in the July issue of Nature Chemistry under the title, “Conformational and functional changes of the native neuropeptide somatostatin occur in the presence of copper and amyloid-β”.
According to the amyloid hypothesis, the abnormal deposition of Aβ proteins causes death of neuronal cells. While Aβ agglomerations make up most of the aged plaques through fibrosis, in recent studies, high concentrations of transitional metal were found in the plaques from Alzheimer’s patients.
This suggests a close interaction between metallic ions and Aβ, which accelerates the fibrosis of proteins. Copper in particular is a redox-activating transition metal that can produce large amounts of oxygen and cause serious oxidative stress on cell organelles. Aβ proteins and transition metals can closely interact with neurotransmitters at synapses, but the direct effects of such abnormalities on the structure and function of neurotransmitters are yet to be understood.
Figure 1. Functional shift of somatostatin (SST) by factors in the pathogenesis of Alzheimer's disease.
Figure 2. Somatostatin’s loss-of-function as neurotransmitter. a. Schematic diagram of SST auto-aggregation due to Alzheimer's pathological factors. b. SST’s aggregation by copper ions. c. Coordination-prediction structure and N-terminal folding of copper-SST. d. Inhibition of SST receptor binding specificity by metals.
In their research, Professor Lim’s team discovered that when somatostatin, the protein-based neurotransmitter, is met with copper, Aβ, and metal-Aβ complexes, self-aggregates and ceases to perform its innate function of transmitting neural signals, but begins to attenuate the toxicity and agglomeration of metal-Aβ complexes.
Figure 3. Gain-of-function of somatostatin (SST) in the dementia setting. a. Prediction of docking of SST and amyloid beta. b. SST making metal-amyloid beta aggregates into an amorphous form. c. Cytotoxic mitigation effect of SST. d. SST mitigating the interaction between amyloid beta protein with the cell membrane.
This research, by Dr. Jiyeon Han et al. from the KAIST Department of Chemistry, revealed the coordination structure between copper and somatostatin at a molecular level through which it suggested the agglomeration mechanism, and discovered the effects of somatostatin on Aβ agglomeration path depending on the presence or absence of metals. The team has further confirmed somatostatin’s receptor binding, interactions with cell membranes, and effects on cell toxicity for the first time to receive international attention.
Professor Mi Hee Lim said, “This research has great significance in having discovered a new role of neurotransmitters in the pathogenesis of Alzheimer’s disease.” “We expect this research to contribute to defining the pathogenic network of neurodegenerative diseases caused by aging, and to the development of future biomarkers and medicine,” she added.
This research was conducted jointly by Professor Seung-Hee Lee’s team of KAIST Department of Biological Sciences, Professor Kiyoung Park’s Team of KAIST Department of Chemistry, and Professor Yulong Li’s team of Peking University.
The research was funded by Basic Science Research Program of the National Research Foundation of Korea and KAIST.
For more information about the research team, visit the website: https://sites.google.com/site/miheelimlab/1-professor-mi-hee-lim.
2022.07.29 View 12815 -
Atomically-Smooth Gold Crystals Help to Compress Light for Nanophotonic Applications
Highly compressed mid-infrared optical waves in a thin dielectric crystal on monocrystalline gold substrate investigated for the first time using a high-resolution scattering-type scanning near-field optical microscope.
KAIST researchers and their collaborators at home and abroad have successfully demonstrated a new platform for guiding the compressed light waves in very thin van der Waals crystals. Their method to guide the mid-infrared light with minimal loss will provide a breakthrough for the practical applications of ultra-thin dielectric crystals in next-generation optoelectronic devices based on strong light-matter interactions at the nanoscale.
Phonon-polaritons are collective oscillations of ions in polar dielectrics coupled to electromagnetic waves of light, whose electromagnetic field is much more compressed compared to the light wavelength. Recently, it was demonstrated that the phonon-polaritons in thin van der Waals crystals can be compressed even further when the material is placed on top of a highly conductive metal. In such a configuration, charges in the polaritonic crystal are “reflected” in the metal, and their coupling with light results in a new type of polariton waves called the image phonon-polaritons. Highly compressed image modes provide strong light-matter interactions, but are very sensitive to the substrate roughness, which hinders their practical application.
Challenged by these limitations, four research groups combined their efforts to develop a unique experimental platform using advanced fabrication and measurement methods. Their findings were published in Science Advances on July 13.
A KAIST research team led by Professor Min Seok Jang from the School of Electrical Engineering used a highly sensitive scanning near-field optical microscope (SNOM) to directly measure the optical fields of the hyperbolic image phonon-polaritons (HIP) propagating in a 63 nm-thick slab of hexagonal boron nitride (h-BN) on a monocrystalline gold substrate, showing the mid-infrared light waves in dielectric crystal compressed by a hundred times.
Professor Jang and a research professor in his group, Sergey Menabde, successfully obtained direct images of HIP waves propagating for many wavelengths, and detected a signal from the ultra-compressed high-order HIP in a regular h-BN crystals for the first time. They showed that the phonon-polaritons in van der Waals crystals can be significantly more compressed without sacrificing their lifetime.
This became possible due to the atomically-smooth surfaces of the home-grown gold crystals used as a substrate for the h-BN. Practically zero surface scattering and extremely small ohmic loss in gold at mid-infrared frequencies provide a low-loss environment for the HIP propagation. The HIP mode probed by the researchers was 2.4 times more compressed and yet exhibited a similar lifetime compared to the phonon-polaritons with a low-loss dielectric substrate, resulting in a twice higher figure of merit in terms of the normalized propagation length.
The ultra-smooth monocrystalline gold flakes used in the experiment were chemically grown by the team of Professor N. Asger Mortensen from the Center for Nano Optics at the University of Southern Denmark.
Mid-infrared spectrum is particularly important for sensing applications since many important organic molecules have absorption lines in the mid-infrared. However, a large number of molecules is required by the conventional detection methods for successful operation, whereas the ultra-compressed phonon-polariton fields can provide strong light-matter interactions at the microscopic level, thus significantly improving the detection limit down to a single molecule. The long lifetime of the HIP on monocrystalline gold will further improve the detection performance.
Furthermore, the study conducted by Professor Jang and the team demonstrated the striking similarity between the HIP and the image graphene plasmons. Both image modes possess significantly more confined electromagnetic field, yet their lifetime remains unaffected by the shorter polariton wavelength. This observation provides a broader perspective on image polaritons in general, and highlights their superiority in terms of the nanolight waveguiding compared to the conventional low-dimensional polaritons in van der Waals crystals on a dielectric substrate.
Professor Jang said, “Our research demonstrated the advantages of image polaritons, and especially the image phonon-polaritons. These optical modes can be used in the future optoelectronic devices where both the low-loss propagation and the strong light-matter interaction are necessary. I hope that our results will pave the way for the realization of more efficient nanophotonic devices such as metasurfaces, optical switches, sensors, and other applications operating at infrared frequencies.”
This research was funded by the Samsung Research Funding & Incubation Center of Samsung Electronics and the National Research Foundation of Korea (NRF). The Korea Institute of Science and Technology, Ministry of Education, Culture, Sports, Science and Technology of Japan, and The Villum Foundation, Denmark, also supported the work.
Figure. Nano-tip is used for the ultra-high-resolution imaging of the image phonon-polaritons in hBN launched by the gold crystal edge.
Publication:
Menabde, S. G., et al. (2022) Near-field probing of image phonon-polaritons in hexagonal boron nitride on gold crystals. Science Advances 8, Article ID: eabn0627. Available online at https://science.org/doi/10.1126/sciadv.abn0627.
Profile:
Min Seok Jang, MS, PhD
Associate Professor
jang.minseok@kaist.ac.kr
http://janglab.org/
Min Seok Jang Research Group
School of Electrical Engineering
http://kaist.ac.kr/en/
Korea Advanced Institute of Science and Technology (KAIST)
Daejeon, Republic of Korea
2022.07.13 View 11807