AI
-
KAIST’s RAIBO2 becomes the World’s First Robo-dog to Successfully Complete a Full-course Marathon
KAIST's quadrupedal walking robot "RAIBO", which can run seamlessly on sandy beaches, has now evolved into "RAIBO2"and achieved the groundbreaking milestone by becomeing the world's first quadrupedal robot to successfully complete a full-course marathon in an official event.
< Photo 1. A group photo of RAIBO2 and the team after completing the full-course marathon >
KAIST (President Kwang Hyung Lee) announced on the 17th of November that Professor Je Min Hwangbo's research team of the Department of Mechanical Engineering participated in the 22nd Sangju Dried-Persimmon Marathon and completed the full-course race (42.195 km) with a time of 4 hours 19 minutes and 52 seconds.
< Photo 2. RAIBO2 after completing the full-course marathon with its official record presented on the photo wall >
The Sangju Dried Persimmon Marathon is known for its challenging course featuring two 50 m elevation climbs, each at the 14 km and 28 km marks, making it defficult for amateur runners. This made it an especially demanding challenge for the walking robot, as unexpected losses in efficiency could occur.
< Photo 3. RAIBO2 with the completion medal around its neck >
To prepare RAIBO2, Professor Hwangbo's team developed a walking controller using reinforcement learning algorithms within their proprietary simulation environment "RaiSim". This simulator allowed the team to simlate diverse terrains such as slopes, stairs, and icy roads to ensure stable walking performance.
In particular, RAIBO2's high torque transparency joint mechanism enable the robot to efficiently harvest energy on the downhill slopes to regain some of the energy used in climbing up steep hill.
In addition, the stability of the robot was greatly improved through the collaboration with RAION ROBOTICS Inc., a company founded by the researchers from Professor Hwangbo’s lab.
< Figure 1. Conceptual diagram of power flow employed by the quadrupedal robot >
< Figure 2. The process of leg posture change of RAIBO2 walking at the most efficient walking speed of 3 m/s. By reducing the ground contact speed of the feet, the collision energy loss was reduced, and by minimizing the slipperiness of the foot upon contact, the body's kinetic energy was maintained towards the direction of the movement. >
Due to the nature of walking, pedal robots must employ highly complex systems that can withstand periodic vibrations from the frequent impacts that occur upon contact with the ground surface. Immediately after development, high efficiency was already recorded in short-distance experiments in the laboratory at the beginning of the year, but the manufacturing technology of RAION ROBOTICS significantly bolstered RAIBO's performance in running safely for a prolonged time of more than 4 hours among random pack of people in an actual marathon.
Compared to previous studies on improving walking efficiency, where external parts or software could not be changed and only limited improvements were made in some areas, Professor Hwangbo’s research team cited the fact that they were able to comprehensively solve problems by developing all steps and parts in-house, including mechanism design, electrical design, software, and artificial intelligence, as a key factor in improving efficiency.
Following the development of RAIBO1, the research team developed RAIBO2 and optimized all aspects of the robot. In particular, the team integrated the motor driver circuitry directly into the robot to minimize actuator losses and increase the control bandwidth, greatly improving walking efficiency and stability.
< Photo 4. RAIBO2 running the full-course marathon along human participants >
Choongin Lee, a Ph.D. Student that co-first author of the studies on RAIBO, said, “Through the marathon project, we demonstrated that RAIBO2 has the walking performance to stably execute services such as delivery and patrol in urban environments with many people and random objects,” and “In follow-up research, we will add autonomous navigation functions to RAIBO and strive to achieve the world’s best walking performance in mountainous and disaster environments.”
< Photo 5. RAIBO2 and co-first authors of the related research at the Ph.D. program of the Department of Mechanical Engineering at KAIST. (From left) Choongin Lee, Donghoon Youm, and Jeongsoo Park >
This research was conducted with the support of Samsung Electronics Future Technology Promotion Center and RAION ROBOTICS Inc.
2024.11.17 View 875 -
KAIST’s Beach-Roaming Quadrupedal Robot “RAIBO” to Run a Marathon!
“RAIBO”, KAIST’s four-legged robot featuring remarkable agility even on challenging terrains like sandy beaches, is now set to be the first in the world to complete a full marathon.
< Photo 1. A group photo of the research team of Professor Je Min Hwangbo (second from the right in the front row) of the Department of Mechanical Engineering who participated in the marathon event at 2024 Geumsan Insam Festival last September >
On the 17th of November, KAIST (represented by President Kwang Hyung Lee) announced that Professor Je Min Hwangbo’s team from the Department of Mechanical Engineering has developed an upgraded version, “RAIBO2,” which will take on the full 42.195-kilometer course at the "Sangju Dried-Persimmon Marathon".
This is over double the previous maximum distance achieved by quadruped robots, which was limited to around 20 kilometers. The KAIST team has successfully developed a robot that can walk continuously for 43 kilometers on a single charge, completing the course in 4 hours and 40 minutes by following a GPS-guided path on the university’s main athletic field. Through this marathon, the team aims to demonstrate RAIBO2’s walking performance in an actual urban environment.
Previously, most measurements of walking robots’ travel distances were confined to controlled laboratory conditions or theoretical data. This marathon challenge is thus significant in that the robot will run alongside the general public in a real urban setting, marking the first attempt to validate the practical potential of four-legged robots in real environments.
Quadruped robots have shown advantages in challenging terrains, such as ice, sand, and mountainous areas, where they can walk stably. However, limited travel distance and running time have long been obstacles to wider applications.
< Figure 1. Conceptual diagram of power flow employed by the quadruped robot >
Professor Hwangbo’s team designed every component of the robot, from its actuators to its mechanical structure, to overcome these limitations. Notably, they implemented an efficient walking control system based on reinforcement learning using their proprietary dynamic simulator “RaiSim”.
The team also collected and analyzed walking data from outdoor environments, creating a model to address walking losses. This model was then used to iteratively improve walking efficiency over one full year.
< Figure 2. The leg posture change process of RAIBO2 walking at the most efficient walking speed of 3 m/s. By reducing the ground contact speed of the feet, the collision energy loss was reduced, and by minimizing the slipperiness of the foot upon contact, the body's kinetic energy was maintained towards the direction of the movement. >
This is the team’s second attempt. Their first was during the marathon event at “Geumsan Insam Festival” in September when the robot’s battery ran out at the 37-kilometer mark, falling short of completion. The battery drained 10 kilometers earlier than expected due to frequent speed changes as the robot adjusted to the pacing of other runners on the course.
Following the initial attempt, the team focused on technical improvements for a successful finish. They enhanced control efficiency by implementing joint stiffness control directly onto the motor actuator and increased battery capacity by 33% by refining the internal structure. These improvements enabled the robot to cover a maximum distance of 67 kilometers on straight paths.
< Figure 3. Data from completing 43 km on a single charge at the main sports field on campus. Left) GPS data of the driving course used during autonomous running. Middle) Covered distance by the hour. Right) Energy consumption by module >
Choongin Lee, a Ph.D. student of RAI Lab who is one of the co-first author of this study, explained, “Our comprehensive analysis of walking losses in terms of mechanics, electrical systems, and walking methods was crucial to improving walking efficiency. This research marks an important milestone in extending the operating range of quadruped robots to urban environments.”
< Photo 2. A Photo from Practice Run>
This research was supported by the Samsung Electronics Future Technology Development Center and RAION ROBOTICS Co., Ltd.
< Photo 3. A Photo from Practice Run >
2024.11.15 View 340 -
KAIST Develops a Fire-risk Free Self-Powered Hydrogen Production System
KAIST researchers have developed a new hydrogen production system that overcomes the current limitations of green hydrogen production. By using a water-splitting system with an aqueous electrolyte, this system is expected to block fire risks and enable stable hydrogen production.
KAIST (represented by President Kwang Hyung Lee) announced on the 22nd of October that a research team led by Professor Jeung Ku Kang from the Department of Materials Science and Engineering developed a self-powered hydrogen production system based on a high-performance zinc-air battery*.
*Zinc-air battery: A primary battery that absorbs oxygen from the air and uses it as an oxidant. Its advantage is long life, but its low electromotive force is a disadvantage.
Hydrogen (H₂) is a key raw material for synthesizing high-value-added substances, and it is gaining attention as a clean fuel with an energy density (142 MJ/kg) more than three times higher than traditional fossil fuels (gasoline, diesel, etc.). However, most current hydrogen production methods impose environmental burden as they emit carbon dioxide (CO₂).
While green hydrogen can be produced by splitting water using renewable energy sources such as solar cells and wind power, these sources are subject to irregular power generation due to weather and temperature fluctuations, leading to low water-splitting efficiency.
To overcome this, air batteries that can emit sufficient voltage (greater than 1.23V) for water splitting have been gaining attention. However, achieving sufficient capacity requires expensive precious metal catalysts and the performance of the catalyst materials becomes significantly degraded during prolonged charge and discharge cycles. Thus, it is essential to develop catalysts that are effective for the water-splitting reactions (oxygen and hydrogen evolution) and materials that can stabilize the repeated charge and discharge reactions (oxygen reduction and evolution) in zinc-air battery electrodes.
In response, Professor Kang's research team proposed a method to synthesize a non-precious metal catalyst material (G-SHELL) that is effective for three different catalytic reactions (oxygen evolution, hydrogen evolution, and oxygen reduction) by growing nano-sized, metal-organic frameworks on graphene oxide.
The team incorporated the developed catalyst material into the air cathode of a zinc-air battery, confirming that it achieved approximately five times higher energy density (797Wh/kg), high power characteristics (275.8mW/cm²), and long-term stability even under repeated charge and discharge conditions compared to conventional batteries.
Additionally, the zinc-air battery, which operates using an aqueous electrolyte, is safe from fire risks. It is expected that this system can be applied as a next-generation energy storage device when linked with water electrolysis systems, offering an environmentally friendly method for hydrogen production.
< Figure 1. Illustrations of a trifunctional graphene-sandwiched heterojunction-embedded layered lattice (G-SHELL) structure. Schematic representation of a) synthesis procedures of G-SHELL from a zeolitic imidazole framework, b) hollow core-layered shell structure with trifunctional sites for oxygen reduction evolution (ORR), oxygen evolution reaction (OER), and hydrogen evolution reaction (HER), and c) heterojunctions, eterojunction-induced internal electric fields, and the corresponding band structure. >
Professor Kang explained, "By developing a catalyst material with high activity and durability for three different electrochemical catalytic reactions at low temperatures using simple methods, the self-powered hydrogen production system we implemented based on zinc-air batteries presents a new breakthrough to overcome the current limitations of green hydrogen production."
<Figure 2. Electrochemical performance of a ZAB-driven water-splitting cell with G-SHELL. Diagram of a self-driven water-splitting cell integrated by combining a ZAB with an alkaline water electrolyzer.>
PhD candidate Dong Won Kim and Jihoon Kim, a master's student in the Department of Materials Science and Engineering at KAIST, were co-first authors of this research, which was published in the international journal Advanced Science on September 17th in the multidisciplinary field of materials science. (Paper Title: “Trifunctional Graphene-Sandwiched Heterojunction-Embedded Layered Lattice Electrocatalyst for High Performance in Zn-Air Battery-Driven Water Splitting”)
This research was supported by the Nano and Material Technology Development Program of the Ministry of Science and ICT and the National Research Foundation of Korea’s Future Technology Research Laboratory.
2024.10.22 View 1030 -
KAIST Develops Thread-like, Flexible Thermoelectric Materials Applicable in Extreme Environments
A team of Korean researchers developed a thermoelectric material that can be used in wearable devices, such as smart clothing, and while maintaining stable thermal energy performance even in extreme environments. It has dramatically resolved the dilemma of striking the balance between achieving good performance and the mechanical flexibility of thermoelectric materials, which has been a long-standing challenge in the field of thermoelectric materials, and has also proven the possibility of commercialization.
KAIST (President Kwang-Hyung Lee) announced on the 21st that a joint research team of Professor Yeon Sik Jung of the Department of Materials Science and Engineering and Professor Inkyu Park of the Department of Mechanical Engineering, in collaboration with the research teams of Professor Min-Wook Oh of Hanbat National University (President Yong Jun Oh) and Dr. Jun-Ho Jeong of the Korea Institute of Machinery and Materials (President Seoghyun Ryu), have successfully developed ‘bismuth telluride (Bi2Te3) thermoelectric fibers,’ an innovative energy harvesting solution for next-generation flexible electronic devices.
Thermoelectric materials are materials that generate voltage when there is a temperature difference and convert thermal energy into electrical energy. Currently, about 70% of energy being lost as wasted heat, so due attention is being given to research on these as sustainable energy materials that can recover and harvesting energy from this waste heat.
Most of the heat sources around us are curved, such as the human body, vehicle exhaust pipes, and cooling fins. Inorganic thermoelectric materials based on ceramic materials boast high thermoelectric performance, but they are fragile and difficult to produce in curved shapes. On the other hand, flexible thermoelectric materials using existing polymer binders can be applied to surfaces of various shapes, but their performance was limited due to the low electrical conductivity and high thermal resistance of the polymer.
Existing flexible thermoelectric materials contain polymer additives, but the inorganic thermoelectric material developed by the research team is not flexible, so they overcame these limitations by twisting nano ribbons instead of additives to produce a thread-shaped thermoelectric material. Inspired by the flexibility of inorganic nano ribbons, the research team used a nanomold-based electron beam deposition technique to continuously deposit nano ribbons and then twisted them into a thread shape to create bismuth telluride (Bi2Te3) inorganic thermoelectric fibers.
These inorganic thermoelectric fibers have higher bending strength than existing thermoelectric materials, and showed almost no change in electrical properties even after repeated bending and tensile tests of more than 1,000 times. The thermoelectric device created by the research team generates electricity using temperature differences, and if clothes are made with fiber-type thermoelectric devices, electricity can be generated from body temperature to operate other electronic devices.
< Figure 1. Schematic diagram and actual image of the all-inorganic flexible thermoelectric yarn made without polymer additives >
In fact, the possibility of commercialization was proven through a demonstration of collecting energy by embedding thermoelectric fibers in life jackets or clothing. In addition, it opened up the possibility of building a high-efficiency energy harvesting system that recycles waste heat by utilizing the temperature difference between the hot fluid inside a pipe and the cold air outside in industrial settings.
Professor Yeon Sik Jung said, "The inorganic flexible thermoelectric material developed in this study can be used in wearable devices such as smart clothing, and it can maintain stable performance even in extreme environments, so it has a high possibility of being commercialized through additional research in the future." Professor Inkyu Park also emphasized, "This technology will become the core of next-generation energy harvesting technology, and it is expected to play an important role in various fields from waste heat utilization in industrial sites to personal wearable self-power generation devices."
This study, in which Hanhwi Jang, a Ph.D. student at KAIST's Department of Materials Science and Engineering, Professor Junseong Ahn of Korea University, Sejong Campus, and Dr. Yongrok Jeong of Korea Atomic Energy Research Institute contributed equally as joint first authors, was published in the online edition of the international academic journal Advanced Materials on September 17, and was selected as the back-cover paper in recognition of its excellence. (Paper title: Flexible All-Inorganic Thermoelectric Yarns)
Meanwhile, this study was conducted through the Mid-career Researcher Support Program and the Future Materials Discovery Program of the National Research Foundation of Korea, and the support from the Global Bio-Integrated Materials Center, the Ministry of Trade, Industry and Energy, and the Korea Institute of Industrial Technology Evaluation and Planning (KEIT) upon the support by the Ministry of Science and ICT.
2024.10.21 View 779 -
KAIST Develops Technology for the Precise Diagnosis of Electric Vehicle Batteries Using Small Currents
Accurately diagnosing the state of electric vehicle (EV) batteries is essential for their efficient management and safe use. KAIST researchers have developed a new technology that can diagnose and monitor the state of batteries with high precision using only small amounts of current, which is expected to maximize the batteries’ long-term stability and efficiency.
KAIST (represented by President Kwang Hyung Lee) announced on the 17th of October that a research team led by Professors Kyeongha Kwon and Sang-Gug Lee from the School of Electrical Engineering had developed electrochemical impedance spectroscopy (EIS) technology that can be used to improve the stability and performance of high-capacity batteries in electric vehicles.
EIS is a powerful tool that measures the impedance* magnitude and changes in a battery, allowing the evaluation of battery efficiency and loss. It is considered an important tool for assessing the state of charge (SOC) and state of health (SOH) of batteries. Additionally, it can be used to identify thermal characteristics, chemical/physical changes, predict battery life, and determine the causes of failures. *Battery Impedance: A measure of the resistance to current flow within the battery that is used to assess battery performance and condition.
However, traditional EIS equipment is expensive and complex, making it difficult to install, operate, and maintain. Moreover, due to sensitivity and precision limitations, applying current disturbances of several amperes (A) to a battery can cause significant electrical stress, increasing the risk of battery failure or fire and making it difficult to use in practice.
< Figure 1. Flow chart for diagnosis and prevention of unexpected combustion via the use of the electrochemical impedance spectroscopy (EIS) for the batteries for electric vehicles. >
To address this, the KAIST research team developed and validated a low-current EIS system for diagnosing the condition and health of high-capacity EV batteries. This EIS system can precisely measure battery impedance with low current disturbances (10mA), minimizing thermal effects and safety issues during the measurement process.
In addition, the system minimizes bulky and costly components, making it easy to integrate into vehicles. The system was proven effective in identifying the electrochemical properties of batteries under various operating conditions, including different temperatures and SOC levels.
Professor Kyeongha Kwon (the corresponding author) explained, “This system can be easily integrated into the battery management system (BMS) of electric vehicles and has demonstrated high measurement accuracy while significantly reducing the cost and complexity compared to traditional high-current EIS methods. It can contribute to battery diagnosis and performance improvements not only for electric vehicles but also for energy storage systems (ESS).”
This research, in which Young-Nam Lee, a doctoral student in the School of Electrical Engineering at KAIST participated as the first author, was published in the prestigious international journal IEEE Transactions on Industrial Electronics (top 2% in the field; IF 7.5) on September 5th. (Paper Title: Small-Perturbation Electrochemical Impedance Spectroscopy System With High Accuracy for High-Capacity Batteries in Electric Vehicles, Link: https://ieeexplore.ieee.org/document/10666864)
< Figure 2. Impedance measurement results of large-capacity batteries for electric vehicles. ZEW (commercial EW; MP10, Wonatech) versus ZMEAS (proposed system) >
This research was supported by the Basic Research Program of the National Research Foundation of Korea, the Next-Generation Intelligent Semiconductor Technology Development Program of the Korea Evaluation Institute of Industrial Technology, and the AI Semiconductor Graduate Program of the Institute of Information & Communications Technology Planning & Evaluation.
2024.10.17 View 1227 -
KAIST Changes the Paradigm of Drug Discovery with World's First Atomic Editing
In pioneering drug development, the new technology that enables the easy and rapid editing of key atoms responsible for drug efficacy has been regarded as a fundamental and "dream" technology, revolutionizing the process of discovering potential drug candidates. KAIST researchers have become the first in the world to successfully develop single-atom editing technology that maximizes drug efficacy.
On October 8th, KAIST (represented by President Kwang-Hyung Lee) announced that Professor Yoonsu Park’s research team from the Department of Chemistry successfully developed technology that enables the easy editing and correction of oxygen atoms in furan compounds into nitrogen atoms, directly converting them into pyrrole frameworks, which are widely used in pharmaceuticals.
< Image. Conceptual image illustrating the main idea of the research >
This research was published in the prestigious scientific journal Science on October 3rd under the title "Photocatalytic Furan-to-Pyrrole Conversion."
Many drugs have complex chemical structures, but their efficacy is often determined by a single critical atom. Atoms like oxygen and nitrogen play a central role in enhancing the pharmacological effects of these drugs, particularly against viruses.
This phenomenon, where the introduction of specific atoms into a drug molecule dramatically affects its efficacy, is known as the "Single Atom Effect." In leading-edge drug development, discovering atoms that maximize drug efficacy is key.
However, evaluating the Single Atom Effect has traditionally required multi-step, costly synthesis processes, as it has been difficult to selectively edit single atoms within stable ring structures containing oxygen or nitrogen.
Professor Park’s team overcame this challenge by introducing a photocatalyst that uses light energy. They developed a photocatalyst that acts as a “molecular scissor,” freely cutting and attaching five-membered rings, enabling single-atom editing at room temperature and atmospheric pressure—a world first.
The team discovered a new reaction mechanism in which the excited molecular scissor removes oxygen from furan via single-electron oxidation and then sequentially adds a nitrogen atom.
Donghyeon Kim and Jaehyun You, the study's first authors and candidates in KAIST’s integrated master's and doctoral program in the Department of Chemistry, explained that this technique offers high versatility by utilizing light energy to replace harsh conditions. They further noted that the technology enables selective editing, even when applied to complex natural products or pharmaceuticals. Professor Yoonsu Park, who led the research, remarked, "This breakthrough, which allows for the selective editing of five-membered organic ring structures, will open new doors for building libraries of drug candidates, a key challenge in pharmaceuticals. I hope this foundational technology will be used to revolutionize the drug development process."
The significance of this research was highlighted in the Perspective section of Science, a feature where a peer scientist of prominence outside of the project group provides commentary on an impactful research.
This research was supported by the National Research Foundation of Korea’s Creative Research Program, the Cross-Generation Collaborative Lab Project at KAIST, and the POSCO Science Fellowship of the POSCO TJ Park Foundation.
2024.10.11 View 1316 -
Unraveling Mitochondrial DNA Mutations in Human Cells
Throughout our lifetime, cells accumulate DNA mutations, which contribute to genetic diversity, or “mosaicism”, among cells. These genomic mutations are pivotal for the aging process and the onset of various diseases, including cancer. Mitochondria, essential cellular organelles involved in energy metabolism and apoptosis, possess their own DNA, which are susceptible to mutations. However, studies on mtDNA mutations and mosaicism have been limited due to a variety of technical challenges.
Genomic scientists from KAIST have revealed the genetic mosaicism characterized by variations in mitochondrial DNA (mtDNA) across normal human cells. This study provides fundamental insights into understanding human aging and disease onset mechanisms.
The study, “Mitochondrial DNA mosaicism in normal human somatic cells,” was published in Nature Genetics on July 22. It was led by graduate student Jisong An under the supervision of Professor Young Seok Ju from the Graduate School of Medical Science and Engineering.
Researchers from Seoul National University College of Medicine, Yonsei University College of Medicine, Korea University College of Medicine, Washington University School of Medicine National Cancer Center, Seoul National University Hospital, Gangnam Severance Hospital and KAIST faculty startup company Inocras Inc. also participated in this study.
< Figure 1. a. Flow of experiment. b. Schematic diagram illustrating the origin and dynamics of mtDNA alterations across a lifetime. >
The study involved a bioinformatic analysis of whole-genome sequences from 2,096 single cells obtained from normal human colorectal epithelial tissue, fibroblasts, and blood collected from 31 individuals. The study highlights an average of three significant mtDNA differences between cells, with approximately 6% of these variations confirmed to be inherited as heteroplasmy from the mother.
Moreover, mutations significantly increased during tumorigenesis, with some mutations contributing to instability in mitochondrial RNA. Based on these findings, the study illustrates a computational model that comprehensively elucidates the evolution of mitochondria from embryonic development to aging and tumorigenesis.
This study systematically reveals the mechanisms behind mitochondrial DNA mosaicism in normal human cells, establishing a crucial foundation for understanding the impact of mtDNA on aging and disease onset.
Professor Ju remarked, “By systematically utilizing whole-genome big data, we can illuminate previously unknown phenomena in life sciences.” He emphasized the significance of the study, adding, “For the first time, we have established a method to systematically understand mitochondrial DNA changes occurring during human embryonic development, aging, and cancer development.”
This work was supported by the National Research Foundation of Korea and the Suh Kyungbae Foundation.
2024.07.24 View 1843 -
A 20-year-old puzzle solved: KAIST research team reveals the 'three-dimensional vortex' of zero-dimensional ferroelectrics
Materials that can maintain a magnetized state by themselves without an external magnetic field (i.e., permanent magnets) are called ferromagnets. Ferroelectrics can be thought of as the electric counterpart to ferromagnets, as they maintain a polarized state without an external electric field. It is well-known that ferromagnets lose their magnetic properties when reduced to nano sizes below a certain threshold. What happens when ferroelectrics are similarly made extremely small in all directions (i.e., into a zero-dimensional structure such as nanoparticles) has been a topic of controversy for a long time.
< (From left) Professor Yongsoo Yang, the corresponding author, and Chaehwa Jeong, the first author studying in the integrated master’s and doctoral program, of the KAIST Department of Physics >
The research team led by Dr. Yongsoo Yang from the Department of Physics at KAIST has, for the first time, experimentally clarified the three-dimensional, vortex-shaped polarization distribution inside ferroelectric nanoparticles through international collaborative research with POSTECH, SNU, KBSI, LBNL and University of Arkansas.
About 20 years ago, Prof. Laurent Bellaiche (currently at University of Arkansas) and his colleagues theoretically predicted that a unique form of polarization distribution, arranged in a toroidal vortex shape, could occur inside ferroelectric nanodots. They also suggested that if this vortex distribution could be properly controlled, it could be applied to ultra-high-density memory devices with capacities over 10,000 times greater than existing ones. However, experimental clarification had not been achieved due to the difficulty of measuring the three-dimensional polarization distribution within ferroelectric nanostructures.
The research team at KAIST successfully solved this 20-year-old challenge by implementing a technique called atomic electron tomography. This technique works by acquiring atomic-resolution transmission electron microscope images of the nanomaterials from multiple tilt angles, and then reconstructing them back into three-dimensional structures using advanced reconstruction algorithms. Electron tomography can be understood as essentially the same method with the CT scans used in hospitals to view internal organs in three dimensions; the KAIST team adapted it uniquely for nanomaterials, utilizing an electron microscope at the single-atom level.
< Figure 1. Three-dimensional polarization distribution of BaTiO3 nanoparticles revealed by atomic electron tomography. >(Left) Schematic of the electron tomography technique, which involves acquiring transmission electron microscope images at multiple tilt angles and reconstructing them into 3D atomic structures.(Center) Experimentally determined three-dimensional polarization distribution inside a BaTiO3 nanoparticle via atomic electron tomography. A vortex-like structure is clearly visible near the bottom (blue dot).(Right) A two-dimensional cross-section of the polarization distribution, thinly sliced at the center of the vortex, with the color and arrows together indicating the direction of the polarization. A distinct vortex structure can be observed.
Using atomic electron tomography, the team completely measured the positions of cation atoms inside barium titanate (BaTiO3) nanoparticles, a well-known ferroelectric material, in three dimensions. From the precisely determined 3D atomic arrangements, they were able to further calculate the internal three-dimensional polarization distribution at the single-atom level. The analysis of the polarization distribution revealed, for the first time experimentally, that topological polarization orderings including vortices, anti-vortices, skyrmions, and a Bloch point occur inside the 0-dimensional ferroelectrics, as theoretically predicted 20 years ago. Furthermore, it was also found that the number of internal vortices can be controlled depending on their sizes.
Prof. Sergey Prosandeev and Prof. Bellaiche (who proposed with other co-workers the polar vortex ordering theoretically 20 years ago), joined this collaboration and further proved that the vortex distribution results obtained from experiments are consistent with theoretical calculations.
By controlling the number and orientation of these polarization distributions, it is expected that this can be utilized into next-generation high-density memory device that can store more than 10,000 times the amount of information in the same-sized device compared to existing ones.
Dr. Yang, who led the research, explained the significance of the results: “This result suggests that controlling the size and shape of ferroelectrics alone, without needing to tune the substrate or surrounding environmental effects such as epitaxial strain, can manipulate ferroelectric vortices or other topological orderings at the nano-scale. Further research could then be applied to the development of next-generation ultra-high-density memory.”
This research, with Chaehwa Jeong from the Department of Physics at KAIST as the first author, was published online in Nature Communications on May 8th (Title: Revealing the Three-Dimensional Arrangement of Polar Topology in Nanoparticles).
The study was mainly supported by the National Research Foundation of Korea (NRF) Grants funded by the Korean Government (MSIT).
2024.05.31 View 3583 -
KAIST and Merck Sign MOU to Boost Biotech Innovation
< (From left) KAIST President Kwang-Hyung Lee and Merck CEO Matthias Heinzel >
KAIST (President Kwang-Hyung Lee) signed a Memorandum of Understanding (MOU) with Merck Life Science (CEO Matthias Heinzel) on May 29 to foster innovation and technology creation in advanced biotechnology.
Since May of last year, the two institutions have been discussing multidimensional innovation programs and will now focus on industry-academia cooperation to tackle bioindustry challenges with this MOU as a foundation.
KAIST will conduct joint research projects in various advanced biotechnology fields, such as synthetic biology, mRNA, cell line engineering, and organoids, using the chemical and biological portfolios provided by Merck.
Additionally, KAIST will establish an Experience Lab in collaboration with the Department of Materials Science and Engineering and the Graduate School of Medical Science and Engineering. This lab will support the discovery and analysis of candidate substances in materials science and biology.
Programs to enhance researchers' capabilities will also be offered. Scholarships for graduate students and awards for professors will be implemented. Researchers will have opportunities to participate in global academic events and educational programs hosted by Merck, such as the Curious 2024 Future Insight Conference and the Innovation Cup.
M Ventures, a venture capital subsidiary of Merck Group, will collaborate with KAIST's startup institute to support technology commercialization and continue to develop their startup ecosystem.
The signing ceremony at KAIST's main campus in Daejeon was attended by the CEO of Merck Life Science and the President of KAIST along with representatives from both institutions.
Matthias Heinzel, a member of the Executive Board of Merck and CEO Life Science, said, “This agreement with KAIST is a significant step toward accelerating the development of the life science industry both in Korea and globally. Advancing life science research and fostering the next generation of scientists is essential for discovering new medicines to meet global health needs.”
President Kwang-Hyung Lee responded, “We are pleased to share a vision for scientific advancement with Merck, a leading global technology company. We anticipate that this partnership will strengthen the connection between Merck’s life science business and the global scientific community.”
In March, Merck, a global science and technology company with over 350 years of history, announced a plan to invest 430 billion KRW (€300 million) to build a bioprocessing center in Daejeon, where KAIST is located. This is Merck's largest investment in the Asia-Pacific region.
2024.05.30 View 2817 -
The World’s First Hacking-preventing Cryptographic Semiconductor Chip
With the dramatic increase in the amount of information exchanged between components or devices in the 5G/6G era, such as for the Internet of Things (IoT) and autonomous driving, hacking attacks are becoming more sophisticated. Consequently, enhancing security functions is essential for safely transmitting data between and among devices.
On February 29th, a KAIST research team led by Professors Yang-gyu Choi and Seung-tak Ryu from the School of Electrical Engineering announced the successful development of the world's first security cryptographic semiconductor.
The team has developed the Cryptoristor, a cryptographic transistor based on FinFET technology, produced through a 100% silicon-compatible process, for the first time in the world. Cryptoristor is a random number generator (RNG) with unparalleled characteristics, featuring a unique structure comprising a single transistor and a distinctive mechanism.
In all security environments, including artificial intelligence, the most crucial element is the RNG. In the most commonly used security chip, the Advanced Encryption Standard (AES), the RNG is a core component, occupying approximately 75% of the total chip area and more than 85% of its energy consumption. Hence, there is an urgent need for the development of low-power/ultra-small RNGs suitable for mobile or IoT devices.
Existing RNGs come with limitations as they lack compatibility with silicon CMOS processes and circuit-based RNGs occupy a large surface area.
In contrast, the team’s newly developed Cryptoristor, a cryptographic semiconductor based on a single-component structure, consumes and occupies less than .001 of the power and area compared to the current chips being used. Utilizing the inherent randomness of FinFETs, fabricated on a Silicon-on-Insulator (SOI) substrate with an insulating layer formed beneath the silicon, the team developed an RNG that unpredictably produces zeroes and ones.
< Figure 1. Conceptual diagram of the security cryptographic transistor device. >
Generally speaking, preventing hackers from predicting the encrypted algorithms during data exchanges through mobile devices is pivotal. Therefore, this method ensures unpredictability by generating random sequences of zeroes and ones that change every time.
Moreover, while the Cryptoristor-based RNG research is the world's first of its kind without any international implementation cases, it shares the same transistor structure as existing logic or memory components. This enables 100% production through rapid mass production processes using existing semiconductor facilities at a low cost.
Seung-il Kim, a PhD student who led the research, explained the significance of the study, stating, "As a cryptographic semiconductor, the ultra-small/low-power random number generator enhances security through its distinctive unpredictability, supporting safe hyperconnectivity with secure transmissions between chips or devices. Particularly, compared to previous research, it offers excellent advantages in terms of energy consumption, integration density, and cost, making it suitable for IoT device environments."
This research, with master’s student Hyung-jin Yoo as the co-author, was officially published in the online edition of Science Advances, a sister journal of Science, in February 2024 (research paper title: Cryptographic transistor for true random number generator with low power consumption).
This research received support from the Next-Generation Intelligent Semiconductor Technology Development Project and the Core Technology Development Project for the National Semiconductor Research Laboratory.
2024.03.07 View 4130 -
KAIST Research Team Creates the Scent of Jasmine from Microorganisms
The fragrance of jasmine and ylang-ylang, used widely in the manufacturing of cosmetics, foods, and beverages, can be produced by direct extraction from their respective flowers. In reality, this makes it difficult for production to meet demand, so companies use benzyl acetate, a major aromatic component of the two fragrances that is chemically synthesized from raw materials derived from petroleum.
On February 26, a KAIST research team led by Research Professor Kyeong Rok Choi from the BioProcess Engineering Research Center and Distinguished Professor Sang Yup Lee from the Department of Chemical and Biomolecular Engineering revealed the development of the first microbial process to effectively produce benzyl acetate, an industrially useful compound, from renewable carbon sources such as glucose. The results were published in their paper titled “A microbial process for the production of benzyl acetate”.
< Figure 1. Production of benzyl acetate through co-culture of upstream and downstream strains harboring the benzoic acid-dependent pathway. >
The team, led by Distinguished Professor Lee, aimed to produce benzyl acetate through an environmentally friendly and sustainable method, and developed an Escherichia coli strand to convert glucose into benzyl acetate through system metabolic engineering*.
*System metabolic engineering: a field of research founded by Distinguished Professor Lee to effectively develop microbial cell plants, a core component of the bio-industry that will replace the existing chemical industry, which is highly dependent on petroleum.
The research team developed a metabolic pathway that biosynthesizes benzyl acetate from benzoic acid derived from glucose, and successfully produced benzyl acetate by co-culturing** the strain.
**co-culture: simultaneously synthesizing two or more types of microorganisms in a mixture
However, it has been confirmed that the enzyme used to convert benzoic acid into benzyl acetate in this co-culturing technique acts non-specifically on an intermediate product during benzoic acid biosynthesis, producing a by-product called cinnamyl acetate. This process consumes the intermediate product needed for benzoic acid biosynthesis, thereby reducing the production efficiency of the target compound, benzyl acetate.
To overcome this problem, Distinguished Professor Lee and his team devised a delayed co-culture method, where they first produced benzoic acid in the earlier stages of fermentation by only culturing the top strain that produces benzoic acid from glucose, and later inoculated the bottom strain to convert the accumulated benzoic acid in the culture medium into benzyl acetate.
By applying this co-culture technique, the team suppressed the formation of by-products without further strain improvement or applying additional enzymes, and multiplied the concentration of the target compound by 10 times, producing 2.2 g/L of benzyl acetate. In addition, the team confirmed its potential for the commercial production of benzyl acetate through a technical economic analysis on this microbial process.
< Figure 2. Delayed co-culture of the Bn1 and Bn-BnAc3 strains for improved production of benzyl acetate through the benzoic acid-independent pathway.>
Research Professor Keyong Rok Choi, who was the first author of this paper, said, “This work is significant in that we have developed an effective microbial process to produce the industrially useful compound benzyl acetate, and also in that we have suggested a new approach to overcome the target chemical efficiency diminution and by-product formation issues caused commonly through non-specific enzyme activities during metabolic engineering.”
Distinguished Professor Lee said, “If we can increase the variety and number of microbial processes that produce useful chemicals through sustainable methods and at the same time develop effective strategies to solve chronic and inevitable problems that arise during microbial strain development, we will be able to accelerate the transition from the petrochemical industry into the eco-friendly and sustainable bio-industry.
This work was published online in Nature Chemical Engineering, issued by Nature.
This research was supported by the ‘Implementation of Intelligent Cell Factory Technology (PI: Distinguished Professor Sang Yup Lee) Project by the Ministry of Science and ICT, and the ‘Development of Protein Production Technology from Inorganic Substances through Microbiological Metabolic System Control’ (PI: Research Professor Kyeong Rok Choi) by the Agricultural Microbiological Project Group at the Rural Development Administration.
2024.03.05 View 3452 -
Genome Sequencing Unveils Mutational Impacts of Radiation on Mammalian Cells
Recent release of the waste water from Japan's Fukushima nuclear disaster stirred apprehension regarding the health implications of radiation exposure. Classified as a Group 1 carcinogen, ionizing radiation has long been associated with various cancers and genetic disorders, as evidenced by survivors and descendants of atomic bombings and the Chernobyl disaster. Despite much smaller amount, we remain consistently exposed to low levels of radiation in everyday life and medical procedures.
Radiation, whether in the form of high-energy particles or electromagnetic waves, is conventionally known to break our cellular DNA, leading to cancer and genetic disorders. Yet, our understanding of the quantitative and qualitative mutational impacts of ionizing radiation has been incomplete.
On the 14th, Professor Young Seok Ju and his research team from KAIST, in collaboration with Dr. Tae Gen Son from the Dongnam Institute of Radiological and Medical Science, and Professors Kyung Su Kim and Ji Hyun Chang from Seoul National University, unveiled a breakthrough. Their study, led by joint first authors Drs. Jeonghwan Youk, Hyun Woo Kwon, Joonoh Lim, Eunji Kim and Tae-Woo Kim, titled "Quantitative and qualitative mutational impact of ionizing radiation on normal cells," was published in Cell Genomics.
Employing meticulous techniques, the research team comprehensively analyzed the whole-genome sequences of cells pre- and post-radiation exposure, pinpointing radiation-induced DNA mutations. Experiments involving cells from different organs of humans and mice exposed to varying radiation doses revealed mutation patterns correlating with exposure levels. (Figure 1)
Notably, exposure to 1 Gray (Gy) of radiation resulted in on average 14 mutations in every post-exposure cell. (Figure 2) Unlike other carcinogens, radiation-induced mutations primarily comprised short base deletions and a set of structural variations including inversions, translocations, and various complex genomic rearrangements. (Figure 3) Interestingly, experiments subjecting cells to low radiation dose rate over 100 days demonstrated that mutation quantities, under equivalent total radiation doses, mirrored those of high-dose exposure.
"Through this study, we have clearly elucidated the effects of radiation on cells at the molecular level," said Prof. Ju at KAIST. "Now we understand better how radiation changes the DNA of our cells," he added.
Dr. Son from the Dongnam Institute of Radiological and Medical Science stated, "Based on this study, we will continue to research the effects of very low and very high doses of radiation on the human body," and further remarked, "We will advance the development of safe and effective radiation therapy techniques."
Professors Kim and Chang from Seoul National University College of Medicine expressed their views, saying, "Through this study, we believe we now have a tool to accurately understand the impact of radiation on human DNA," and added, "We hope that many subsequent studies will emerge using the research methodologies employed in this study."
This research represents a significant leap forward in radiation studies, made possible through collaborative efforts and interdisciplinary approaches. This pioneering research engaged scholars from diverse backgrounds, spanning from the Genetic Engineering Research Institute at Seoul National University, the Cambridge Stem Cell Institute in the UK, the Institute for Molecular Biotechnology in Austria (IMBA), and the Genome Insight Inc. (a KAIST spin-off start-up). This study was supported by various institutions including the National Research Foundation of Korea, Dongnam Institute of Radiological and Medical Science (supported by Ministry of Science and ICT, the government of South Korea), the Suh Kyungbae Foundation, the Human Frontier Science Program (HFSP), and the Korea University Anam Hospital Korea Foundation for the Advancement of Science and Creativity, the Ministry of Science and ICT, and the National R&D Program.
2024.02.15 View 3860