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Key Figures in the Establishment of KAIST, Specially Invited to the Presidential Office’s National Appointment Ceremony
KAIST announced on August 6 that Professor Emeritus Jung-Woong Ra from the Department of Electrical Engineering and Won-ki Kwon, former Vice Minister of the Ministry of Science and Technology, who played pivotal roles in the establishment of KAIST, were selected as special guests for the 'National Appointment Ceremony' hosted by the Presidential Office on August 15th.
The Presidential Office selected special invitees across eight categories for the ceremony. These include individuals born in 1945 (referred to as 'Liberation Babies'), those involved in the founding of KAIST in 1971, independence activists and national patriots, overseas workers in Germany and the Middle East, AI industry professionals, residents from regions facing depopulation, leading figures in K-culture, military personnel, firefighters, police officers, families of fallen public servants and victims of social disasters, as well as promising talents in economics, science, culture, and the arts.
Considering the historical significance of its establishment and its symbolic meaning for the development of national science and technology, KAIST Professor Emeritus Jung-Woong Ra, who was a key figure in the establishment of the Department of Electrical Engineering after being appointed as a professor in 1971, and former Vice Minister Kwon Won-ki, who was the first practical leader of the establishment project. Both were officially included on the special invitation list.
Briefing from the Presidential Office regarding the 'National Appointment Ceremony' (2025.07.28) https://www.president.go.kr/newsroom/briefing/grehGMuP
2025.08.06 View 119 -
Immune Signals Directly Modulate Brain's Emotional Circuits: Unraveling the Mechanism Behind Anxiety-Inducing Behaviors
KAIST's Department of Brain and Cognitive Sciences, led by Professor Jeong-Tae Kwon, has collaborated with MIT and Harvard Medical School to make a groundbreaking discovery. For the first time globally, their joint research has revealed that cytokines, released during immune responses, directly influence the brain's emotional circuits to regulate anxiety behavior.
The study provided experimental evidence for a bidirectional regulatory mechanism: inflammatory cytokines IL-17A and IL-17C act on specific neurons in the amygdala, a region known for emotional regulation, increasing their excitability and consequently inducing anxiety. Conversely, the anti-inflammatory cytokine IL-10 was found to suppress excitability in these very same neurons, thereby contributing to anxiety alleviation.
In a mouse model, the research team observed that while skin inflammation was mitigated by immunotherapy (IL-17RA antibody), anxiety levels paradoxically rose. This was attributed to elevated circulating IL-17 family cytokines leading to the overactivation of amygdala neurons.
Key finding: Inflammatory cytokines IL-17A/17C promote anxiety by acting on excitable amygdala neurons (via IL-17RA/RE receptors), whereas anti-inflammatory cytokine IL-10 alleviates anxiety by suppressing excitability through IL-10RA receptors on the same neurons.
The researchers further elucidated that the anti-inflammatory cytokine IL-10 works to reduce the excitability of these amygdala neurons, thereby mitigating anxiety responses.
This research marks the first instance of demonstrating that immune responses, such as infections or inflammation, directly impact emotional regulation at the level of brain circuits, extending beyond simple physical reactions. This is a profoundly significant achievement, as it proposes a crucial biological mechanism that interlinks immunity, emotion, and behavior through identical neurons within the brain.
The findings of this research were published in the esteemed international journal Cell on April 17th of this year.
Paper Information:
Title: Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety
Journal: Cell (Vol. 188, 2190–2220), April 17, 2025
DOI: https://doi.org/10.1016/j.cell.2025.03.005
Corresponding Authors: Professor Gloria Choi (MIT), Professor Jun R. Huh (Harvard Medical School)
2025.07.24 View 340 -
KAIST School of Transdisciplinary Studies Is Driving Innovation in Korean Education
<(From Left) Professor Jaeseung Jeong, haed of the School of Transdiciplinary Studies, Dr, Albert Chau, Vice President of Hong Kong Baptist University>
KAIST (President Kwang Hyung Lee) announced on the 24th of July that its School of Transdisciplinary Studies has been consistently showcasing the results of its experiments and practices for educational innovation both domestically and abroad.
On June 27, Professor Jaeseung Jeong, head of the School of Transdisciplinary Studies, was invited to speak at the “Pacific Asia Summit on Transdisciplinary Education 2025 (PASTE 2025)” held at Hong Kong Baptist University. He presented the Korean model of transdisciplinary education under the title “The Philosophy and Achievements of the KAIST School of Transdisciplinary Studies.”
In his talk, Professor Jeong pointed out the limitations of conventional education systems that rely on answer-centered evaluation, perfectionism, and competitiveness, claiming that they hinder creativity and integrative thinking. He then introduced the philosophy and operational practices of the School of Transdisciplinary Studies, which was established in 2019 to overcome these issues.
Professor Jeong outlined five key principles that define the school's educational philosophy: ①a broad and integrative academic foundation, ②student-driven and customized education, ③creativity and execution, ④a sense of social responsibility and global citizenship, and ⑤learning driven by intrinsic motivation and curiosity. He explained that students are admitted without a declared major, allowed to design their own learning plans, and evaluated under a P/NR system* that focuses on growth rather than competition.
*P/NR system: A non-competitive grading system led by KAIST’s School of Transdisciplinary Studies. Instead of traditional letter grades (A/B/C/Fail), students receive Pass (P) or No Record (NR), with the latter not appearing as a failure and not affecting GPA.
Professor Jeong emphasized, “This experiment at KAIST represents a new educational paradigm that values questions over knowledge, culture over structure, and inquiry over competition. Students are bridging academic learning and real-world practice by addressing societal challenges through technology, which could lead to a fundamental shift in global higher education.”
His presentation provided an opportunity to spotlight how KAIST’s experimental approach to nurturing transdisciplinary talent is pointing to new directions for the global education community beyond Korea.
< Hyungjoon Jang, a student at the School of Transdisciplinary Studies>
The achievements of KAIST’s transdisciplinary education model are also reflected in students’ academic accomplishments. Hyungjoon Jang, a student at the School of Transdisciplinary Studies, participated in a collaborative study led by his mentor, Professor Jaekyung Kim in the Department of Mathematical Sciences, along with researchers from Chungnam National University and the Institute for Basic Science (IBS). Their groundbreaking analytical method enables the accurate estimation of inhibition constants using only a single inhibitor concentration. The paper was published in the prestigious journal Nature Communications in June, with Jang listed as co–first author.
Jang played a leading role throughout the research process by developing the experimental methodology, creating a software package to support the method, drafting the manuscript, and engaging in peer review. He also effectively communicated mathematical and statistical models to pharmaceutical experts by mastering presentation techniques and visual explanation strategies, thereby setting a strong example of interdisciplinary collaboration.
He emphasized that “the School of Transdisciplinary Studies’ mentor system allowed regular research feedback and the systematic acquisition of essential knowledge and analytical skills through courses in biochemistry and computational neuroscience.”
This example demonstrates how undergraduate students at the School of Transdisciplinary Studies can take leading roles in cutting-edge interdisciplinary research.
The school’s educational philosophy is also reflected in students’ practical actions. Inseo Jeong, a current student and founder of the startup MPAge Inc., made a meaningful donation to help establish a creative makerspace in the school.
<Inseo Jeong, founder of MPAG>
Inseo Jeong explained that the decision was made to express gratitude for the knowledge gained and the mentorship received from professors, saying that at the School of Transdisciplinary Studies, she learned not only how to solve problems with technology but also how to view society, and that learning has helped her grow. She added, “The deep understanding of humanity and the world emphasized by Professor Jaeseung Jeong will be a great asset not only to entrepreneurs but to all students pursuing diverse paths,” expressing support for her fellow students.
Inseo Jeong collaborated for over two years with Professor Hyunwook Ka of the School of Transdisciplinary Studies on software research for individuals with hearing impairments. After numerous algorithm designs and experimental iterations, their work, which considered the social scalability of technology, was presented at the world-renowned CSUN Assistive Technology Conference held at California State University, Northridge. The project has filed for a patent under KAIST’s name.
※ Presentation title: Evidence-Based Adaptive Transcription for Sign Language Users
KAIST is now working to complete the makerspace on the third floor of the Administrative Annex (N2) in Room 314 with a size of approximately 33 m2 during the summer. The makerspace is expected to serve as a hands-on, integrative learning environment where various ideas can be realized and implemented, playing a key role in fostering students’ creative problem-solving and integrative thinking skills.
KAIST President Kwang Hyung Lee stated, “The School of Transdisciplinary Studies is both an experimental ground and a practical field for overcoming the limitations of traditional education and nurturing global talents with creative problem-solving skills and integrative thinking, which are essential for the future.” He added, “KAIST will continue to lead efforts to cultivate question-asking, inquiry-driven, transdisciplinary talents and propose new paradigms for education and research.”
2025.07.24 View 295 -
Why Do Plants Attack Themselves? The Secret of Genetic Conflict Revealed
<Professor Ji-Joon Song of the KAIST Department of Biological Sciences>
Plants, with their unique immune systems, sometimes launch 'autoimmune responses' by mistakenly identifying their own protein structures as pathogens. In particular, 'hybrid necrosis,' a phenomenon where descendant plants fail to grow healthily and perish after cross-breeding different varieties, has long been a difficult challenge for botanists and agricultural researchers. In response, an international research team has successfully elucidated the mechanism inducing plant autoimmune responses and proposed a novel strategy for cultivar improvement that can predict and avoid these reactions.
Professor Ji-Joon Song's research team at KAIST, in collaboration with teams from the National University of Singapore (NUS) and the University of Oxford, announced on the 21st of July that they have elucidated the structure and function of the 'DM3' protein complex, which triggers plant autoimmune responses, using cryo-electron microscopy (Cryo-EM) technology.
This research is drawing attention because it identifies defects in protein structure as the cause of hybrid necrosis, which occurs due to an abnormal reaction of immune receptors during cross-breeding between plant hybrids.
This protein (DM3) is originally an enzyme involved in the plant's immune response, but problems arise when the structure of the DM3 protein is damaged in a specific protein combination called 'DANGEROUS MIX (DM)'.
Notably, one variant of DM3, the 'DM3Col-0' variant, forms a stable complex with six proteins and is recognized as normal, thus not triggering an immune response. In contrast, another 'DM3Hh-0' variant has improper binding between its six proteins, causing the plant to recognize it as an 'abnormal state' and trigger an immune alarm, leading to autoimmunity.
The research team visualized this structure using atomic-resolution cryo-electron microscopy (Cryo-EM) and revealed that the immune-inducing ability is not due to the enzymatic function of the DM3 protein, but rather to 'differences in protein binding affinity.'
<Figure 1. Mechanism of Plant Autoimmunity Triggered by the Collapse of the DM3 Protein Complex>
This demonstrates that plants can initiate an immune response by recognizing not only 'external pathogens' but also 'internal protein structures' when they undergo abnormal changes, treating them as if they were pathogens.
The study shows how sensitively the plant immune system changes and triggers autoimmune responses when genes are mixed and protein structures change during the cross-breeding of different plant varieties. It significantly advanced the understanding of genetic incompatibility that can occur during natural cross-breeding and cultivar improvement processes.
Dr. Gijeong Kim, the co-first author, stated, "Through international research collaboration, we presented a new perspective on understanding the plant immune system by leveraging the autoimmune phenomenon, completing a high-quality study that encompasses structural biochemistry, genetics, and cell biological experiments."
Professor Ji-Joon Song of the KAIST Department of Biological Sciences, who led the research, said, "The fact that the immune system can detect not only external pathogens but also structural abnormalities in its own proteins will set a new standard for plant biotechnology and crop breeding strategies. Cryo-electron microscopy-based structural analysis will be an important tool for understanding the essence of gene interactions."
This research, with Professor Ji-Joon Song and Professor Eunyoung Chae of the University of Oxford as co-corresponding authors, Dr. Gijeong Kim (currently a postdoctoral researcher at the University of Zurich) and Dr. Wei-Lin Wan of the National University of Singapore as co-first authors, and Ph.D candidate Nayun Kim, as the second author, was published on July 17th in Molecular Cell, a sister journal of the international academic journal Cell.
This research was supported by the KAIST Grand Challenge 30 project.
Article Title: Structural determinants of DANGEROUS MIX 3, an alpha/beta hydrolase that triggers NLR-mediated genetic incompatibility in plants DOI: https://doi.org/10.1016/j.molcel.2025.06.021
2025.07.21 View 391 -
KAIST Shows That the Brain Can Distinguish Glucose: Clues to Treat Obesity and Diabetes
<(From left)Prof. Greg S.B Suh, Dr. Jieun Kim, Dr. Shinhye Kim, Researcher Wongyo Jeong)
“How does our brain distinguish glucose from the many nutrients absorbed in the gut?” Starting with this question, a KAIST research team has demonstrated that the brain can selectively recognize specific nutrients—particularly glucose—beyond simply detecting total calorie content. This study is expected to offer a new paradigm for appetite control and the treatment of metabolic diseases.
On the 9th, KAIST (President Kwang Hyung Lee) announced that Professor Greg S.B. Suh’s team in the Department of Biological Sciences, in collaboration with Professor Young-Gyun Park’s team (BarNeuro), Professor Seung-Hee Lee’s team (Department of Biological Sciences), and the Albert Einstein College of Medicine in New York, had identified the existence of a gut-brain circuit that allows animals in a hungry state to selectively detect and prefer glucose in the gut.
Organisms derive energy from various nutrients including sugars, proteins, and fats. Previous studies have shown that total caloric information in the gut suppresses hunger neurons in the hypothalamus to regulate appetite. However, the existence of a gut-brain circuit that specifically responds to glucose and corresponding brain cells had not been demonstrated until now.
In this study, the team successfully identified a “gut-brain circuit” that senses glucose—essential for brain function—and regulates food intake behavior for required nutrients.
They further proved, for the first time, that this circuit responds within seconds to not only hunger or external stimuli but also to specific caloric nutrients directly introduced into the small intestine, particularly D-glucose, through the activity of “CRF neurons*” in the brain’s hypothalamus.
*CRF neurons: These neurons secrete corticotropin-releasing factor (CRF) in the hypothalamus and are central to the hypothalamic-pituitary-adrenal (HPA) axis, the body’s core physiological system for responding to stress. CRF neurons are known to regulate neuroendocrine balance in response to stress stimuli.
Using optogenetics to precisely track neural activity in real time, the researchers injected various nutrients—D-glucose, L-glucose, amino acids, and fats—directly into the small intestines of mice and observed the results.
They discovered that among the CRF neurons located in the paraventricular nucleus (PVN)* of the hypothalamus, only those specific to D-glucose showed selective responses. These neurons did not respond—or showed inverse reactions—to other sugars or to proteins and fats. This is the first demonstration that single neurons in the brain can guide nutrient-specific responses depending on gut nutrient influx.
*PVN (Paraventricular Nucleus): A key nucleus within the hypothalamus responsible for maintaining bodily homeostasis.
The team also revealed that glucose-sensing signals in the small intestine are transmitted via the spinal cord to the dorsolateral parabrachial nucleus (PBNdl) of the brain, and from there to CRF neurons in the PVN. In contrast, signals for amino acids and fats are transmitted to the brain through the vagus nerve, a different pathway.
In optogenetic inhibition experiments, suppressing CRF neurons in fasting mice eliminated their preference for glucose, proving that this circuit is essential for glucose-specific nutrient preference.
This study was inspired by Professor Suh’s earlier research at NYU using fruit flies, where he identified “DH44 neurons” that selectively detect glucose and sugar in the gut. Based on the hypothesis that hypothalamic neurons in mammals would show similar functional responses to glucose, the current study was launched.
To test this hypothesis, Dr. Jineun Kim (KAIST Ph.D. graduate, now at Caltech) demonstrated during her doctoral research that hungry mice preferred glucose among various intragastrically infused nutrients and that CRF neurons exhibited rapid and specific responses.
Along with Wongyo Jung (KAIST B.S. graduate, now Ph.D. student at Caltech), they modeled and experimentally confirmed the critical role of CRF neurons. Dr. Shinhye Kim, through collaboration, revealed that specific spinal neurons play a key role in conveying intestinal nutrient information to the brain.
Dr. Jineun Kim and Dr. Shinhye Kim said, “This study started from a simple but fundamental question—‘How does the brain distinguish glucose from various nutrients absorbed in the gut?’ We have shown that spinal-based gut-brain circuits play a central role in energy metabolism and homeostasis by transmitting specific gut nutrient signals to the brain.”
Professor Suh added, “By identifying a gut-brain pathway specialized for glucose, this research offers a new therapeutic target for metabolic diseases such as obesity and diabetes. Our future research will explore similar circuits for sensing other essential nutrients like amino acids and fats and their interaction mechanisms.”
Ph.D. student Jineun Kim, Dr. Shinhye Kim, and student Wongyo Jung (co-first authors) contributed to this study, which was published online in the international journal Neuron on June 20, 2025.
※ Paper Title: Encoding the glucose identity by discrete hypothalamic neurons via the gut-brain axis ※ DOI: https://doi.org/10.1016/j.neuron.2025.05.024
This study was supported by the Samsung Science & Technology Foundation, the National Research Foundation of Korea (NRF) Leader Research Program, the POSCO Cheongam Science Fellowship, the Asan Foundation Biomedical Science Scholarship, the Institute for Basic Science (IBS), and the KAIST KAIX program.
2025.07.09 View 651 -
KAIST Develops Novel Candidiasis Treatment Overcoming Side Effects and Resistance
<(From left) Ph. D Candidate Ju Yeon Chung, Prof.Hyun Jung Chung, Ph.D candidate Seungju Yang, Ph.D candidate Ayoung Park, Dr. Yoon-Kyoung Hong from Asan Medical Center, Prof. Yong Pil Chong, Dr. Eunhee Jeon>
Candida, a type of fungus, which can spread throughout the body via the bloodstream, leading to organ damage and sepsis. Recently, the incidence of candidiasis has surged due to the increase in immunosuppressive therapies, medical implants, and transplantation. Korean researchers have successfully developed a next-generation treatment that, unlike existing antifungals, selectively acts only on Candida, achieving both high therapeutic efficacy and low side effects simultaneously.
KAIST (President Kwang Hyung Lee) announced on the 8th that a research team led by Professor Hyun-Jung Chung of the Department of Biological Sciences, in collaboration with Professor Yong Pil Jeong's team at Asan Medical Center, developed a gene-based nanotherapy (FTNx) that simultaneously inhibits two key enzymes in the Candida cell wall.
Current antifungal drugs for Candida have low target selectivity, which can affect human cells. Furthermore, their therapeutic efficacy is gradually decreasing due to the emergence of new resistant strains. Especially for immunocompromised patients, the infection progresses rapidly and has a poor prognosis, making the development of new treatments to overcome the limitations of existing therapies urgent.
The developed treatment can be administered systemically, and by combining gene suppression technology with nanomaterial technology, it effectively overcomes the structural limitations of existing compound-based drugs and successfully achieves selective treatment against only Candida.
The research team created a gold nanoparticle-based complex loaded with short DNA fragments called antisense oligonucleotides (ASO), which simultaneously target two crucial enzymes—β-1,3-glucan synthase (FKS1) and chitin synthase (CHS3)—important for forming the cell wall of the Candida fungus.
By applying a surface coating technology that binds to a specific glycolipid structure (a structure combining sugar and fat) on the Candida cell wall, a targeted delivery device was implemented. This successfully achieved a precise targeting effect, ensuring the complex is not delivered to human cells at all but acts selectively only on Candida.
<Figure 1: Overview of antifungal therapy design and experimental approach>
This complex, after entering Candida cells, cleaves the mRNA produced by the FKS1 and CHS3 genes, thereby inhibiting translation and simultaneously blocking the synthesis of cell wall components β-1,3-glucan and chitin. As a result, the
Candida cell wall loses its structural stability and collapses, suppressing bacterial survival and proliferation.
In fact, experiments using a systemic candidiasis model in mice confirmed the therapeutic effect: a significant reduction in
Candida count in the organs, normalization of immune responses, and a notable increase in survival rates were observed in the treated group.
Professor Hyun-Jung Chung, who led the research, stated, "This study presents a method to overcome the issues of human toxicity and drug resistance spread with existing treatments, marking an important turning point by demonstrating the applicability of gene therapy for systemic infections". She added, "We plan to continue research on optimizing administration methods and verifying toxicity for future clinical application."
This research involved Ju Yeon Chung and Yoon-Kyoung Hong as co-first authors , and was published in the international journal 'Nature Communications' on July 1st.
Paper Title: Effective treatment of systemic candidiasis by synergistic targeting of cell wall synthesis
DOI: 10.1038/s41467-025-60684-7
This research was supported by the Ministry of Health and Welfare and the National Research Foundation of Korea.
2025.07.08 View 596 -
KAIST Presents a Breakthrough in Overcoming Drug Resistance in Cancer – Hope for Treating Intractable Diseases like Diabetes
<(From the left) Prof. Hyun Uk Kim, Ph.D candiate Hae Deok Jung, Ph.D candidate Jina Lim, Prof.Yoosik Kim from the Department of Chemical and Biomolecular Engineering>
One of the biggest obstacles in cancer treatment is drug resistance in cancer cells. Conventional efforts have focused on identifying new drug targets to eliminate these resistant cells, but such approaches can often lead to even stronger resistance. Now, researchers at KAIST have developed a computational framework to predict key metabolic genes that can re-sensitize resistant cancer cells to treatment. This technique holds promise not only for a variety of cancer therapies but also for treating metabolic diseases such as diabetes.
On the 7th of July, KAIST (President Kwang Hyung Lee) announced that a research team led by Professors Hyun Uk Kim and Yoosik Kim from the Department of Chemical and Biomolecular Engineering had developed a computational framework that predicts metabolic gene targets to re-sensitize drug-resistant breast cancer cells. This was achieved using a metabolic network model capable of simulating human metabolism.
Focusing on metabolic alterations—key characteristics in the formation of drug resistance—the researchers developed a metabolism-based approach to identify gene targets that could enhance drug responsiveness by regulating the metabolism of drug-resistant breast cancer cells.
< Computational framework that can identify metabolic gene targets to revert the metabolic state of the drug-resistant cells to that of the drug-sensitive parental cells>
The team first constructed cell-specific metabolic network models by integrating proteomic data obtained from two different types of drug-resistant MCF7 breast cancer cell lines: one resistant to doxorubicin and the other to paclitaxel. They then performed gene knockout simulations* on all of the metabolic genes and analyzed the results.
*Gene knockout simulation: A computational method to predict changes in a biological network by virtually removing specific genes.
As a result, they discovered that suppressing certain genes could make previously resistant cancer cells responsive to anticancer drugs again. Specifically, they identified GOT1 as a target in doxorubicin-resistant cells, GPI in paclitaxel-resistant cells, and SLC1A5 as a common target for both drugs.
The predictions were experimentally validated by suppressing proteins encoded by these genes, which led to the re-sensitization of the drug-resistant cancer cells.
Furthermore, consistent re-sensitization effects were also observed when the same proteins were inhibited in other types of breast cancer cells that had developed resistance to the same drugs.
Professor Yoosik Kim remarked, “Cellular metabolism plays a crucial role in various intractable diseases including infectious and degenerative conditions. This new technology, which predicts metabolic regulation switches, can serve as a foundational tool not only for treating drug-resistant breast cancer but also for a wide range of diseases that currently lack effective therapies.”
Professor Hyun Uk Kim, who led the study, emphasized, “The significance of this research lies in our ability to accurately predict key metabolic genes that can make resistant cancer cells responsive to treatment again—using only computer simulations and minimal experimental data. This framework can be widely applied to discover new therapeutic targets in various cancers and metabolic diseases.”
The study, in which Ph.D. candidates JinA Lim and Hae Deok Jung from KAIST participated as co-first authors, was published online on June 25 in Proceedings of the National Academy of Sciences (PNAS), a leading multidisciplinary journal that covers top-tier research in life sciences, physics, engineering, and social sciences.
※ Title: Genome-scale knockout simulation and clustering analysis of drug-resistant breast cancer cells reveal drug sensitization targets ※ DOI: https://doi.org/10.1073/pnas.2425384122 ※ Authors: JinA Lim (KAIST, co-first author), Hae Deok Jung (KAIST, co-first author), Han Suk Ryu (Seoul National University Hospital, corresponding author), Yoosik Kim (KAIST, corresponding author), Hyun Uk Kim (KAIST, corresponding author), and five others.
This research was supported by the Ministry of Science and ICT through the National Research Foundation of Korea, and the Electronics and Telecommunications Research Institute (ETRI).
2025.07.08 View 952 -
KAIST Enhances Immunotherapy for Difficult-to-Treat Brain Tumors with Gut Microbiota
< Photo 1.(From left) Prof. Heung Kyu Lee, Department of Biological Sciences,
and Dr. Hyeon Cheol Kim>
Advanced treatments, known as immunotherapies that activate T cells—our body's immune cells—to eliminate cancer cells, have shown limited efficacy as standalone therapies for glioblastoma, the most lethal form of brain tumor. This is due to their minimal response to glioblastoma and high resistance to treatment.
Now, a KAIST research team has now demonstrated a new therapeutic strategy that can enhance the efficacy of immunotherapy for brain tumors by utilizing gut microbes and their metabolites. This also opens up possibilities for developing microbiome-based immunotherapy supplements in the future.
KAIST (President Kwang Hyung Lee) announced on July 1 that a research team led by Professor Heung Kyu Lee of the Department of Biological Sciences discovered and demonstrated a method to significantly improve the efficiency of glioblastoma immunotherapy by focusing on changes in the gut microbial ecosystem.
The research team noted that as glioblastoma progresses, the concentration of ‘tryptophan’, an important amino acid in the gut, sharply decreases, leading to changes in the gut microbial ecosystem. They discovered that by supplementing tryptophan to restore microbial diversity, specific beneficial strains activate CD8 T cells (a type of immune cell) and induce their infiltration into tumor tissues. Through a mouse model of glioblastoma, the research team confirmed that tryptophan supplementation enhanced the response of cancer-attacking T cells (especially CD8 T cells), leading to their increased migration to tumor sites such as lymph nodes and the brain.
In this process, they also revealed that ‘Duncaniella dubosii’, a beneficial commensal bacterium present in the gut, plays a crucial role. This bacterium helped T cells effectively redistribute within the body, and survival rates significantly improved when used in combination with immunotherapy (anti-PD-1).
Furthermore, it was demonstrated that even when this commensal bacterium was administered alone to germ-free mice (mice without any commensal microbes), the survival rate for glioblastoma increased. This is because the bacterium utilizes tryptophan to regulate the gut environment, and the metabolites produced in this process strengthen the ability of CD8 T cells to attack cancer cells.
Professor Heung Kyu Lee explained, "This research is a meaningful achievement, showing that even in intractable brain tumors where immune checkpoint inhibitors had no effect, a combined strategy utilizing gut microbes can significantly enhance treatment response."
Dr. Hyeon Cheol Kim of KAIST (currently a postdoctoral researcher at the Institute for Biological Sciences) participated as the first author. The research findings were published online in Cell Reports, an international journal in the life sciences, on June 26.
This research was conducted as part of the Basic Research Program and Bio & Medical Technology Development Program supported by the Ministry of Science and ICT and the National Research Foundation of Korea.
※Paper Title: Gut microbiota dysbiosis induced by brain tumor modulates the efficacy of immunotherapy
※DOI: https://doi.org/10.1016/j.celrep.2025.115825
2025.07.02 View 1267 -
2025 KAIST Global Entrepreneurship Summer School Concludes Successfully in Silicon Valley
< A group photo taken at the 2025 GESS Special Lecture.Vice President So Young Kim from the International Office, VC Jay Eum from GFT Ventures, Professor Byungchae Jin from the Impact MBA Program at the Business School, and Research Assistant Professor Sooa Lee from the Office of Global Initiative>
The “2025 KAIST Global Entrepreneurship Summer School (2025 KAIST GESS),” organized by the Office of Global Initiative of the KAIST International Office (Vice President So Young Kim), successfully concluded. Now in its fourth year, the program was designed to provide KAIST students with firsthand experience of the world’s leading startup ecosystem in Silicon Valley, USA, and to strengthen their practical capabilities to take on challenges on the global stage.
This year’s 2025 KAIST GESS welcomed approximately 40 participants, including 24 undergraduate and graduate students selected through document screening, interviews, team presentations, mentoring, and peer evaluations, as well as 16 Impact MBA students from the College of Business. The selected undergraduate and graduate participants underwent two months of pre-program training and received mentoring from experienced entrepreneurs to refine their business models and elevate their project ideas. Meanwhile, Impact MBA students joined the Silicon Valley program onsite, attending key lectures and networking sessions to broaden their understanding of the global startup ecosystem.
From June 22nd, participants spent seven days in Silicon Valley completing the global entrepreneurship curriculum. The program was operated in cooperation with major organizations including the KOTRA Silicon Valley IT Center, Korea-US AI Semiconductor Innovation Center (K-ASIC), and Plug and Play Tech Center. Local experts delivered lectures on topics such as “Startup Culture,” “Learning from Failures” and “Networks and Capital.”
Participants also had the opportunity to visit startups led by KAIST alumni and local entrepreneurs, gaining valuable insights from firsthand stories about global entrepreneurship. Companies visited included Medic Life Sciences (CEO Kyuho Han) and ImpriMed (CEO Sungwon Lim). Through these visits, participants received practical advice on market entry strategies and overcoming challenges in the global arena.
As part of their first onsite schedule, KAIST students attended an interactive fireside chat titled “Global Entrepreneurship and AI,” where they engaged in in-depth discussions on the future of AI-driven global startups. The session featured three distinguished speakers: Jay Kim, Head of US Business Development at Hyper Accel; Chandra Shekhar Dhir, AI/ML Director at JPMorgan Chase’s Machine Learning Center of Excellence; and Taesu Kim, co-founder of AI voice synthesis startup Neosapience and KAIST alumnus. Taesu Kim shared, “Facing serious health issues made me reflect on my life, and after recovering, I wanted to pursue something that could create a real impact on society, which led me to start my own company.” He also advised students to “take time at important turning points in life to deeply think about what you truly want to do and how you can contribute to society.
In line with the core value of ‘paying it forward’—a fundamental principle of global entrepreneurship learned in Silicon Valley—GESS participants engaged in a community service project titled “Let’s Play with AI+Tech,” organized in collaboration with the Sunnyvale community and Foothill College. Leveraging their strong foundation in AI, KAIST students designed and led a hands-on ‘Doodle AI’ educational program to make foundational AI concepts accessible and engaging for underrepresented local elementary school children and their parents, fostering meaningful community interaction.
On the final day of the 2025 KAIST GESS, a pitch competition was held with participation from Silicon Valley venture capitalists and accelerators. Participants presented their business models, developed over the two-month program, to a panel of judges. The winning team was eaureco, and Si Li Sara Aow (Civil and Environmental Engineering) shared, “GESS was a valuable opportunity to test and hone practical entrepreneurship skills beyond mere networking.” She added, “At first, I lacked confidence, but challenging myself to pitch in the final presentation gave me the courage to take one step closer to global entrepreneurship. Pitching in Silicon Valley, the heart of global startups, was an invaluable experience that will shape my path as a global entrepreneur.”
The program concluded with a special lecture by Jay Eum, a seasoned Silicon Valley venture capitalist and a judging panel member for GESS over the past three years. He shared key insights on startup success from an investor’s perspective, advising, “The journey of entrepreneurship is never easy, but the sooner you start, the better.” He further encouraged participants to “focus on solving problems in local markets, but do not fear challenging global markets,” inspiring them with courage and actionable advice.
So Young Kim, Director of the KAIST Office of Global Initiative, said, “We hope the 2025 KAIST GESS serves as a stepping stone for KAIST students to grow into influential entrepreneurs on the global stage,” adding, “This program is also expected to further enhance KAIST’s international reputation.”
Byungchae Jin, Faculty Chair of the KAIST Impact MBA, College of Business, highlighted the program's educational benefits, stating, “Engaging directly with local entrepreneurs and gaining practical experience in Silicon Valley's startup environment provide students with hands-on learning and significant inspiration.”
The 2025 KAIST GESS was jointly hosted by the KAIST Office of Global Initiative, Impact MBA, and Startup KAIST. Moving forward, KAIST plans to continue expanding its field-based global entrepreneurship education by linking with key global hubs like Silicon Valley, fostering next-generation global leaders who will lead innovation and challenge the status quo.
2025.07.01 View 1277 -
KAIST Invites World-Renowned Scholars, Elevating Global Competitiveness
< Photo 1. (From left) Professor John Rogers, Professor Gregg Rothermel, Dr. Sang H. Choi >
KAIST announced on June 27th that it has appointed three world-renowned scholars, including Professor John A. Rogers of Northwestern University, USA, as Invited Distinguished Professors in key departments such as Materials Science and Engineering.
Professor John A. Rogers (Northwestern University, USA) will be working with the Department of Materials Science and Engineering from July 2025 to June 2028 with Professor Gregg Rothermel (North Carolina State University, USA) working with the School of Computing from August 2025 to July 2026, and Dr. Sang H. Choi (NASA Langley Research Center, USA) with the Department of Aerospace Engineering from May 2025 to April 2028.
Professor John A. Rogers, a person of global authority in the field of bio-integrated electronics, has been leading advanced convergence technologies such as flexible electronics, smart skin, and implantable sensors. His significant impact on academia and industry is evident through over 900 papers published in top-tier academic journals like Science, Nature, and Cell, and he comes in an H-index of 240*. His research group, the Rogers Research Group at Northwestern University, focuses on "Science that brings Solutions to Society," encompassing areas such as bio-integrated microsystems and unconventional nanofabrication techniques. He is the founding Director of the Querrey-Simpson Institute of Bioelectronics at Northwestern University.
* H-index 240: An H-index is a measurement used to assess the research productivity and impact of an individual authors. H-index 240 means that 240 or more papers have been cited at least 240 times each, indicating a significant impact and the presumable status as a world-class scholar.
The Department of Materials Science and Engineering plans to further enhance its research capabilities in next-generation bio-implantable materials and wearable devices and boost its global competitiveness through the invitation of Professor Rogers. In particular, it aims to create strong research synergies by linking with the development of bio-convergence interface materials, a core task of the Leading Research Center (ERC, total research budget of 13.5 billion KRW over 7 years) led by Professor Kun-Jae Lee.
Professor Gregg Rothermel, a world-renowned scholar in software engineering, was ranked second among the top 50 global researchers by Communications of the ACM. For over 30 years, he has conducted practical research to improve software reliability and quality. He has achieved influential research outcomes through collaborations with global companies such as Boeing, Microsoft, and Lockheed Martin. Dr. Rothermel's research at North Carolina State University focuses on software engineering and program analysis, with significant contributions through initiatives like the ESQuaReD Laboratory and the Software-Artifact Infrastructure Repository (SIR).
The School of Computing plans to strengthen its research capabilities in software engineering and conduct collaborative research on software design and testing to enhance the reliability and safety of AI-based software systems through the invitation of Professor Gregg Rothermel. In particular, he is expected to participate in the Big Data Edge-Cloud Service Research Center (ITRC, total research budget of 6.7 billion KRW over 8 years) led by Professor In-Young Ko of the School of Computing, and the Research on Improving Complex Mobility Safety (SafetyOps, Digital Columbus Project, total research budget of 3.5 billion KRW over 8 years), contributing to resolving uncertainties in machine learning-based AI software and advancing technology.
Dr. Sang H. Choi, a global expert in space exploration and energy harvesting, has worked at NASA Langley Research Center for over 40 years, authoring over 200 papers and reports, holding 45 patents, and receiving 71 awards from NASA. In 2022, he was inducted into the 'Inventors Hall of Fame' as part of NASA's Technology Transfer Program. This is a rare honor, recognizing researchers who have contributed to the private sector dissemination of space exploration technology, with only 35 individuals worldwide selected to date. Dr. Choi's extensive work at NASA includes research on advanced electronic and energetic materials, satellite sensors, and various nano-technologies.
Dr. Choi plans to collaborate with Associate Professor Hyun-Jung Kim (former NASA Research Scientist, 2009-2024), who joined the Department of Aerospace Engineering in September of 2024, to lead the development of core technologies for lunar exploration (energy sources, sensing, in-situ resource utilization ISRU).
KAIST President Kwang Hyung Lee stated, "It is very meaningful to be able to invite these world-class scholars. Through these appointments, KAIST will further strengthen its global competitiveness in research in the fields of advanced convergence technology such as bio-convergence electronics, AI software engineering, and space exploration, securing our position as the leader of global innovations."
2025.06.27 View 2099 -
New and Highly Efficient Recycling Technology to Turn Used Tires into Raw Materials for Rubber and Nylon
< (From left) Kyungmin Choi (MS-Ph.D. integrated course, Department of Chemistry), Dr. Beomsoon Park, Professor Soon Hyeok Hong, Dr. Kyoungil Cho >
Approximately 1.5 billions of tires are discarded globally every year, and this is identified as one of the major causes of serious environmental pollution. The research team at the Department of Chemistry at KAIST has achieved a breakthrough by selectively converting waste tires into high-purity cyclic alkenes, valuable chemical building blocks used in the production of rubber and nylon fibers. This advance marks a new milestone in chemical recycling technology for waste tires.
The team, led by Professor Soon Hyeok Hong, has developed a dual-catalyst-based reaction system that overcomes the long-standing challenges associated with recycling vulcanized rubber materials.
Tires are composed of complex blends of synthetic and natural rubber, and their physical strength and durability are reinforced with additives such as silica, carbon black, and antioxidants. In particular, cross-linking between rubber chains is formed through the vulcanization process, giving them a structure resistant to heat and pressure, which is one of the main reasons why chemical recycling of waste tires is difficult.
Until now, waste tire recycling has mainly relied on pyrolysis or mechanical recycling methods. The pyrolysis method is a technology that decomposes polymer chains at high temperatures of 350-800°C to convert them into fuel oil, but it clearly has limitations such as high energy consumption, low selectivity, and the production of low-quality hydrocarbon mixtures.
To solve these problems, the research team developed a method to convert waste rubber into useful chemicals using dual catalysis. The first catalyst helps to break down rubber molecules by changing their bonding structure, and the second catalyst creates cyclic compounds through a ring-closing reaction.
This process shows high selectivity of up to 92% and a yield of 82%. The produced cyclopentene can be recycled into rubber, and cyclohexene can be used as a raw material for nylon fibers, making them industrially very valuable.
The research team successfully applied the developed system to discarded waste tires, achieving selective conversion into high-purity cyclic alkenes. Unlike the existing pyrolysis method, this is evaluated as a new turning point in the field of waste tire recycling as it can produce high-value chemicals through low-temperature precision catalytic reactions.
In addition, this catalytic platform is compatible with a wide range of synthetic and waste rubbers, positioning it as a promising foundation for scalable, circular solutions in the polymer and materials industries.
< Figure 1. Development of a Catalytic Method for Chemical Recycling of Waste Rubber >
Professor Hong stated, "This research offers an innovative solution for the chemical recycling of waste tires. We aim to develop next-generation high-efficiency catalysts and lay the groundwork for commercialization to enhance economic feasibility. Ultimately, our goal is to contribute to solving the broader waste plastic problem through fundamental chemistry."
This research, in which Beomsoon Park, Kyoungil Cho, and Kyungmin Choi participated, was supported by the National Research Foundation of Korea and was published online in the internationally renowned academic journal ‘Chem’ on June 18th.
※Paper Title: Catalytic and Selective Chemical Recycling of Post-Consumer Rubbers into Cycloalkenes
※DOI: 10.1016/j.chempr.2025.102625
2025.06.26 View 2332 -
KAIST's Li-Fi - Achieves 100 Times Faster Speed and Enhanced Security of Wi-Fi
- KAIST-KRISS Develop 'On-Device Encryption Optical Transmitter' Based on Eco-Friendly Quantum Dots
- New Li-Fi Platform Technology Achieves High Performance with 17.4% Device Efficiency and 29,000 nit Brightness, Simultaneously Improving Transmission Speed and Security
- Presents New Methodology for High-Speed and Encrypted Communication Through Single-Device-Based Dual-Channel Optical Modulation
< Photo 1. (Front row from left) Seungmin Shin, First Author; Professor Himchan Cho; (Back row from left) Hyungdoh Lee, Seungwoo Lee, Wonbeom Lee; (Top left) Dr. Kyung-geun Lim >
Li-Fi (Light Fidelity) is a wireless communication technology that utilizes the visible light spectrum (400-800 THz), similar to LED light, offering speeds up to 100 times faster than existing Wi-Fi (up to 224 Gbps). While it has fewer limitations in available frequency allocation and less radio interference, it is relatively vulnerable to security breaches as anyone can access it. Korean researchers have now proposed a new Li-Fi platform that overcomes the limitations of conventional optical communication devices and can simultaneously enhance both transmission speed and security.
KAIST (President Kwang Hyung Lee) announced on the 24th that Professor Himchan Cho's research team from the Department of Materials Science and Engineering, in collaboration with Dr. Kyung-geun Lim of the Korea Research Institute of Standards and Science (KRISS, President Ho-Seong Lee) under the National Research Council of Science & Technology (NST, Chairman Young-Sik Kim), has developed 'on-device encryption optical communication device' technology for the utilization of 'Li-Fi,' which is attracting attention as a next-generation ultra-high-speed data communication.
Professor Cho's team created high-efficiency light-emitting triode devices using eco-friendly quantum dots (low-toxicity and sustainable materials). The device developed by the research team is a mechanism that generates light using an electric field. Specifically, the electric field is concentrated in 'tiny holes (pinholes) in the permeable electrode' and transmitted beyond the electrode. This device utilizes this principle to simultaneously process two input data streams.
Using this principle, the research team developed a technology called 'on-device encryption optical transmitter.' The core of this technology is that the device itself converts information into light and simultaneously encrypts it. This means that enhanced security data transmission is possible without the need for complex, separate equipment.
External Quantum Efficiency (EQE) is an indicator of how efficiently electricity is converted into light, with a general commercialization standard of about 20%. The newly developed device recorded an EQE of 17.4%, and its luminance was 29,000 nit, significantly exceeding the maximum brightness of a smartphone OLED screen, which is 2,000 nit, demonstrating a brightness more than 10 times higher.
< Figure 1. Schematic diagram of the device structure developed by the research team and encrypted communication >
Furthermore, to more accurately understand how this device converts information into light, the research team used a method called 'transient electroluminescence analysis.' They analyzed the light-emitting characteristics generated by the device when voltage was instantaneously applied for very short durations (hundreds of nanoseconds = billionths of a second). Through this analysis, they investigated the movement of charges within the device at hundreds of nanoseconds, elucidating the operating mechanism of dual-channel optical modulation implemented within a single device.
Professor Himchan Cho of KAIST stated, "This research overcomes the limitations of existing optical communication devices and proposes a new communication platform that can both increase transmission speed and enhance security."
< Photo 2. Professor Himchan Cho, Department of Materials Science and Engineering >
He added, "This technology, which strengthens security without additional equipment and simultaneously enables encryption and transmission, can be widely applied in various fields where security is crucial in the future."
This research, with Seungmin Shin, a Ph.D. candidate at KAIST's Department of Materials Science and Engineering, participating as the first author, and Professor Himchan Cho and Dr. Kyung-geun Lim of KRISS as co-corresponding authors, was published in the international journal 'Advanced Materials' on May 30th and was selected as an inside front cover paper.※ Paper Title: High-Efficiency Quantum Dot Permeable electrode Light-Emitting Triodes for Visible-Light Communications and On-Device Data Encryption※ DOI: https://doi.org/10.1002/adma.202503189
This research was supported by the National Research Foundation of Korea, the National Research Council of Science & Technology (NST), and the Korea Institute for Advancement of Technology.
2025.06.24 View 2450