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Professor Yong-Hee Lee of Physics Received the Humboldt Research Award
In recognition of his past accomplishments in research and teaching, Professor Yong-Hee Lee of Physics at KAIST received the Humboldt Research Award in November 2013. The Humboldt Research Award is annually given by the Alexander von Humboldt Foundation to internationally renowned scientists and scholars in the fields of biology, chemistry, computer science, economics, linguistics, management, mathematics, medicine, philosophy, and physics. The winners of the award are offered with 60,000 Euros of research grant as well as an opportunity to undertake prolonged periods of research in collaboration with researchers in Germany.Professor Lee, who may be the first Korean physicist receiving the award, plans to conduct joint research with colleagues at the Technical University of Berlin and University of Würzburg.
2014.01.05 View 7903 -
KAIST Student Awarded Prize from Energy Saving Contest
Jun-Min Kwon, an undergraduate student in the Department of Chemistry at KAIST, was awarded a prize from the Ministry of Trade, Industry and Energy, Republic of Korea, at the 35th Energy Saving Contest which was held on November 20.
The student club he has been leading was also selected as one of the best groups by the Save Energy Save Earth (SESE), a volunteer organization supported by the Korea Energy Management Corporation and the Ministry of Knowledge Economy, Republic of Korea.
Kwon began promoting energy conservation through a blog and participated in related meetings and workshops as a high school student to improve the understanding on the importance of energy saving and recycling.He also received awards from the Second National Assembly Forum on Climate Change, the Korean National Science Fair, as well as the Samsung Human Tech Paper Award.
2013.12.24 View 10810 -
Nanoparticle based Super Lens selected as 2013 Science and Technology News
Professor Yong-keun Park
"Nanoparticle-based Super Lens", an article by KAIST Physics Department’s Professor Yong-keun Park and Professor Yong-hoon Cho’s joint research team, has been selected as one of the ten representative 2013 Science and Technology News, by the Korea Federation of Science and Technology Societies.
This new concept super lens uses the scattering of light, which can yield over three times more superior resolution of previous optical lenses.
Unlike the conventional optical lens that utilizes refraction of the light, the super lens can give the image of viruses and structure within the cell at 100㎚. This lens is also applicable to state-of-the-art optical and semiconductor processes.
In addition, this year's research achievements also include the successful launch of Naro, a new technology to remove the brain cell membrane which gives a more transparent view of the brain, a new drug to inhibit cancer metastasis, as well as the development of ultra-wide-angle insect eye camera technology.
Articles for 2013 Science and Technology News are chosen in three trial reviews by committee and online voting by 5,437 people over the course of [two weeks]14 days, from November 21st to December 4th.
2013.12.14 View 9426 -
Therapy developed to induce Angiogenesis of Retina
- Junyeop Lee, Graduate School of Medical Sciences and Engineering
- Research results expected to be applied for treatment of diabetic retinopathy
A major clue to treatment of retinovascular disease, which causes blindness, has been found. The key to protection of the retinal nerve is the angiogenic protein that promotes healthy retinal vessel growth around the retina, which usually does not receive blood supply readily. This research offers a beginning to the possible improvement of therapy for diabetic retinopathy1 and retinopathy of prematurity2. Also important to the research is the fact that the ophthalmology specialist researcher, currently undergoing professional training, provided the results.
KAIST Graduate School of Medical Sciences and Engineering’s Junyeop Lee is the opthalmology specialist, who carried out the research under supervision by academic advisers Gyuyeong Go and Wookjun Yoo. The Ministry of Science, ICT and Future Planning as well as the National Research Foundation of Korea have funded his research. The research results have been published as a cover paper on ‘Science Translational Medicine’ on 18th August. This journal is a sister publication of Science, which is prestigious in the field of translational medicine that ties the basic science with clinical medicine. (Thesis title: Angiopoietin-1 Guides Directional Angiogenesis Through Integrin αvβ5 Signaling for Recovery of Ischemic Retinopathy)
The traditional treatment of diabetic retinopathy includes laser photocoagulation to destroy the retinal tissues or antibody therapeutics, which prevents vessel proliferation and blood leaking. The advantage of antibody therapeutics3 is that it retains the retinal nerves, however, it is not the fundamental solution but merely a temporary one, which requires repeated treatments.
The research team identified that Angiopoietin-14 protein, known as essential for growth and stabilization of vessels, also plays an important role in retinal vessel growth. The protein protects the retinal nerves, as well as provides improvement for retinal ischemia5 that is the root cause of vision loss due to retinal hemorrhages. It is expected to become a key to finding fundamental treatment method – by providing sufficient blood supply to the retina, thereby preserving the retinal nerve functions.
The results show that administration of Angiopoietin-1 to retinopathy mouse model promotes growth of healthy vessel growth, further preventing abnormal vessel growth, retinal hemorrhage and vision loss due to retinal ischemia.
Junyeop Lee said, “This research has identified that Angiopoietin-1 is an important factor in retinal vessel generation and stabilization. The paradigm will shift from traditional treatment method, which prevents vessel growth, to a new method that generates healthy vessels and strengthens vessel functions.”
1 Diabetic retinopathy: This retinovascular disease is a diabetic complication caused by insufficient blood supply. It is the major causes of blindness in adults.
2 Retinopathy of prematurity: The retinal vascular disease that occurs in premature infants with incomplete retinal vascular development. It is also the most common cause of blindness in children.
3 Antibody Therapeutics: Antibody developed to selectively inhibit abnormal blood vessel growth and leakage. Typical antibody therapeutics is Avastin and Lucentis, which hinder vascular endothelial growth factor (VEGF).
4 Angiopoietin-1: A critical growth factor that induces the production of healthy blood vessels and maintains the stability of the created vessel.
5 Retinal ischemia: State of ailment where retinal tissue blood supply is not sufficient.
Figure 1. Retinopathy mouse models show that, in comparison to the control group, the VEGF-Trap treatment and Angiopoietin-1 (Ang1) treatment groups significantly suppresses the pathological vascular proliferation. In addition, the Ang 1 group show vessel growth toward the central avascular area (region of retinal ischemia), which is not observed in VEGF-Trap treatment.
Figure 2. Reduced retinal ischemia, retinal bleeding and blood vessel normalization by Angiopoietin-1. Retinal ischemic region (arrow) and retinal bleeding significantly reduced in the Angiopoietin-1 (Ang1) treatment model in comparison to control group (left). The newly generated vessels in Ang 1 model are structurally supported by perivascular cells as normal retinal vessels do (right).
2013.10.12 View 10467 -
New Structural Insight into Neurodegenerative Disease
A research team from the Korea Advanced Institute of Science and Technology (KAIST) released their results on the structure and molecular details of the neurodegenerative disease-associated protein Ataxin-1. Mutations in Ataxin-1 cause the neurological disease, Spinocerebella Ataxia Type 1 (SCA1), which is characterized by a loss of muscular coordination and balance (ataxia), as is seen in Parkinson’s, Alzheimer’s, and Huntington’s diseases.
SCA1-causing mutations in the ATAXIN1 gene alter the length of a glutamine stretch in the Ataxin-1 protein. The research team provides the first structural insight into the complex formation of ATAXIN-1 with its binding partner, Capicua (CIC). The team, led by Professor Ji-Joon Song from the Department of Biological Sciences at KAIST, solved the structure of Ataxin-1 and CIC complex in atomic level revealing molecular details of the interaction between Ataxin-1 and CIC.
Professor Song explained his recent research work,
“We are able to see the intricate process of complex formation and reconfiguration of the two proteins when they interact with each other. Our work, we expect, will provide a new therapeutic target to modulate SCA1 neurodegenerative disease.”
Understanding structural and molecular details of proteins at the atomic level will help researchers to track the molecular pathogenesis of the disease and, ultimately, design targeted therapies or treatments for patients, rather than just relieving the symptoms of diseases.
Professor Song’s research paper, entitled “Structural Basis of Protein Complex Formation and Reconfiguration by Polyglutamine Disease Protein ATAXIN-1 and Capicua,” will be published in the March 15th issue of Genes & Development (www.genesdev.org).
Complex Formation and Reconfiguration of ATAXIN-1 and Capicua
The complex formation between a polyglutamine disease protein, ATXIN-1 and the transcriptional repressor Capicua (CIC) plays a critical role in SCA 1 pathogenesis. The image shows that the homodimerization of ATXIN-1 (yellow and red) is disrupted upon binding of CIC (blue). Furthermore, the binding of CIC to the ATXIN-1 induces a new form of ATXIN-1 dimerization mediated by CICs (ATXIN-1 AXH domains are shown in yellow and red, and CIC peptides shown in blue and white).
2013.04.02 View 8509 -
Ligand Recognition Mechanism of Protein Identified
Professor Hak-Sung Kim
-“Solved the 50 year old mystery of how protein recognises and binds to ligands”
- Exciting potential for understanding life phenomena and the further development of highly effective therapeutic agent development
KAIST’s Biological Science Department’s Professor Hak-Sung Kim, working in collaboration with Professor Sung-Chul Hong of Department of Physics, Seoul National University, has identified the mechanism of how the protein recognizes and binds to ligands within the human body.
The research findings were published in the online edition of Nature Chemical Biology (March 18), which is the most prestigious journal in the field of life science.
Since the research identified the mechanism, of which protein recognises and binds to ligands, it will take an essential role in understanding complex life phenomenon by understanding regulatory function of protein.
Also, ligand recognition of proteins is closely related to the cause of various diseases. Therefore the research team hopes to contribute to the development of highly effective treatments.
Ligands, well-known examples include nucleic acid and proteins, form the structure of an organism or are essential constituents with special functions such as information signalling.
In particular, the most important role of protein is recognising and binding to a particular ligand and hence regulating and maintaining life phenomena. The abnormal occurrence of an error in recognition of ligands may lead to various diseases.
The research team focused on the repetition of change in protein structure from the most stable “open form” to a relatively unstable “partially closed form”.
Professor Kim’s team analysed the change in protein structure when binding to a ligand on a molecular level in real time to explain the ligand recognition mechanism.
The research findings showed that ligands prefer the most stable protein structure. The team was the first in the world to identify that ligands alter protein structure to the most stable, the lowest energy level, when it binds to the protein.
In addition, the team found that ligands bind to unstable partially-closed forms to change protein structure.
The existing models to explain ligand recognition mechanism of protein are “Induced Custom Model”, which involves change in protein structure in binding to ligands, and the “Structure Selection Model”, which argues that ligands select and recognise only the best protein structure out of many. The academic world considers that the team’s research findings have perfectly proved the models through experiments for the first time in the world.
Professor Kim explained, “In the presence of ligands, there exists a phenomenon where the speed of altering protein structure is changed. This phenomenon is analysed on a molecular level to prove ligand recognition mechanism of protein for the first time”. He also said, “The 50-year old mystery, that existed only as a hypothesis on biology textbooks and was thought never to be solved, has been confirmed through experiments for the first time.”
Figure 1: Proteins, with open and partially open form, recognising and binding to ligands.
Figure 2: Ligands temporarily bind to a stable protein structure, open form, which changes into the most stable structure, closed form. In addition, binding to partially closed form also changes protein structure to closed form.
2013.04.01 View 10345 -
Op-Ed by Professor David Helfman: Global Science and Education in Korea for the 21st Century
Professor David Helfman from the Department of Biological Sciences and Graduate School of Nanoscience and Technology contributed an op-ed, “Global Science and Education in Korea for the 21st Century, to the Korea Herald on February 20, 2013. For the article, please click the link below:
http://www.koreaherald.com/view.php?ud=20130220000623.
2013.02.26 View 9369 -
Op-Ed by Prof. David Helfman: Global Science and Education in the 21st Century
Professor David Helfman from the Department of Biological Sciences and Graduate School of Nanoscience and Technology(https://sites.google.com/site/cellsignalinglaboratory/home) recently wrote an Op-Ed in the January 2013 issue of Journal of Happy Scientists and Engineers that ispublished by the Ministry of Science, Education and Technology, the Republic of Korea. In the article entitled “Global Science and Education in the 21st Century,” Professor Helfman addressed three important issues in science and education, which will have a great impact for the development of world-leading universities in Korea. For the article, please see the attachment.
2013.01.22 View 10869
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Ph.D. students Hyowon Park and Won Ma receive Grand Prizes in Mathematics and Biology respectively.
Researchers in KAIST received best paper awards in two out of three fields at this year’s award ceremony for the “Second Annual Best Thesis Paper Award” held collectively by the Korea University Presidents’ Federation (with Chairman DaeSoon Lee) and the Korean Academy of Science and Technology (with Director GilSang Jung).
Two researchers from KAIST, Hyowon Park (Department of Mathematics) and Won Ma (Department of Biology) received best paper awards.
This prize, given by the both the Korea University Presidents’ Federation and the Korean Academy of Science and Technology since last year, is awarded to researchers and assistant professors who write the most outstanding thesis papers in the field of basic sciences.
Park, who received the best paper award this year, did research on graph braid groups. He was supervised by Professor Kihyung Ko, who received the best supervisor reward.
Ma, who received the best paper award in the field of biological science, researched about the Attention Deficit/Hyperactivity Disorder due to deficiency of the GIT1 synapse protein. His supervising professor also received the supervisor award.
The award ceremony was held in the auditorium of the S-OIL headquarters in Seoul on November 30.
Meanwhile, NASA researcher Jaehwa Lee received the best paper award in the field of earth science, and his supervising professor, Professor Jun Kim from Yonsei University who studies atmospheric science, received the best supervisor award.
2012.12.21 View 9506
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The 2nd 'Humanities Lecture for Citizens" to be held
The Department of Humanities and Social Sciences (HSS) at KAIST will hold its 2nd ‘Humanities Lecture for Citizens’, making high level humanities and social science programs available to ordinary citizens.
The program will start on October 16th and will provide one lecture a week for 8 weeks. The lectures will start every Tuesday from 3pm to 5pm at the KAIST international conference room in the N4 building.
The lecture topics include love, psychology, food culture, public opinion, gender and technology- issues that are widely cited throughout society, but are hard to define. The program will end with field trips to the Daejeon Museum of Art and the Ungno Lee Museum of Art.
Professor Shin Dong Won, who managed the program said that ‘this will be a great opportunity for citizens to participate in HSS lectures and to self reflect on social matters.
Lecture Topics (in Korean)
이원재 KAIST 문화기술대학원 교수 <사랑의 역설과 소셜 네트워크>
김정훈 KAIST 인문사회과학과 교수 <심리학적 지식의 불편한 진실>
이석봉 대덕넷 대표 <디지털 시대의 아날로그 해법 ‘종이 신문’>
김동주 KAIST 인문사회과학과 교수 <우리 시대의 먹거리 문화에 대한 성찰 : 고대 인류는 무엇을 먹고 살았을까?>
신피터경섭 KAIST 인문사회과학과 교수<삼성 대 애플, 최후의 승자는?>
박현석 KAIST 인문사회과학과 교수 <여론 조사와 대통령 선거: 과연 국민의 뜻은 무엇인가?>
윤정로 KAIST 인문사회과학과 교수 <여성의 눈으로 본 과학 기술>
김원준 KAIST 경영과학과 교수가 <요즘 왜 자꾸 통섭, 융합이 화두인가?>
2012.10.20 View 6512
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Professor Yoon Dong Ki becomes first Korean to Receive the Michi Nakata Prize
Professor Yoon Dong Ki (Graduate School of Nano Science and Technology) became the first Korean to receive the Michi Nakata Prize from the International Liquid Crystal Society.
The Awards Ceremony was held on the 23rd of August in Mainz, Germany in the 24th Annual International Liquid Crystal Conference.
The Michi Nakata Prize was initiated in 2008 and is rewarded every two years to a young scientist that made a ground breaking discovery or experimental result in the field of liquid crystal. Professor Yoon is the first Korean recipient of the Michi Nakata Prize.
Professor Yoon is the founder of the patterning field that utilizes the defect structure formed by smectic displays. He succeeded in large scale patterning complex chiral nano structures that make up bent-core molecules.
Professor Yoon’s experimental accomplishment was published in the Advanced Materials magazine and the Proc. Natl. Acad. Sci. U.S.A. and also as the cover dissertation of Liquid Crystals magazine.
Professor Yoon is currently working on Three Dimensional Nano Patterning of Supermolecular Liquid Crystal and is part of the World Class University organization.
2012.09.11 View 11236
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The hereditary factor of autism revealed
Korean researchers have successfully investigated the causes and hereditary factors for autistic behavior and proposed a new treatment method with fewer side effects.
This research was jointly supported by the Ministry of Education, Science and Technology and the National Research Foundation as part of the Leading Researcher and Science Research Center Program
The research findings were publishing in the June edition of Nature magazine and will also be introduced in the July edition of Nature Reviews Drug Discovery, under the title ‘Autistic-like social behavior in Shank2-mutant mice improved by restoring NMDA receptor function’.
The research team found that lack of Shank2 genes in mice, which are responsible for the production of synapse proteins, caused autistic-like behavior. The results strongly suggested that the Shank2 gene was linked to autistic behavior and that Shank2 deficiency induced autistic behaviors.
Autism is a neural development disorder characterized by impaired social interaction, repetitive behavior, mental retardation, anxiety and hyperactivity. Around 100 million people worldwide display symptoms of autistic behavior. Recent studies conducted by the University of Washington revealed that 1 out of 3 young adults who display autistic behavior do not fit into the workplace or get accepted to college, a much higher rate than any other disorder. However, an effective cure has not yet been developed and current treatments are limited to reducing repetitive behavior.
The research team confirmed autistic-like social behavior in mice without the Shank2 genes and that the mice had decreased levels of neurotransmission in the NMDA receptor. The mice also showed damaged synaptic plasticity* in the hippocampus**.
* Plasticity: ability of the connectionbetween two neurons to change in strength in response to transmission of information
**Hippocampus: part of the brain responsible for short-term and long-term memory as well as spatial navigation.
The research team also found out that, to restore the function of the NMDA receptor, the passive stimulation of certain receptors, such as the mGLuR5, yielded better treatment results than the direct stimulation of the NMDA. This greatly reduces the side effects associated with the direct stimulation of receptors, resulting in a more effective treatment method.
This research successfully investigated the function of the Shank2 gene in the nerve tissue and showed how the reduced function of the NMDA receptor, due to the lack of the gene, resulted in autistic behavior. It also provided new possibilities for the treatment of autistic behavior and impaired social interaction
2012.06.24 View 10788