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Professor Young-Ho Cho elected as head of international academic conference
KAIST’s Professor Young-Ho Cho of the Department of Bio and Brain Engineering was appointed as the head of the PowerMems (Power Micro Electro Mechanical Systems) symposium to be held at Se-Jong Hotel in Seoul from November 15-18, 2011.
Professor Jo is America’s first engineering doctor in the field of MEMS and is the founding member of the BSAC (Berkeley Sensor and Actuator Center), the start of the MEMS technology.
PowerMEMS is the core of green growth and next generation energy production. It focuses on harvesting energy from minute vibrations or renewable energy sources such as sunlight or plants to harvest and store energy via micro or even nano size systems.
The symposium was first held in 2000, and it is where leading experts in the field share papers on the production and harvesting energy in the micro scale.
2011.01.14 View 10356 -
New drug targeting method for microbial pathogens developed using in silico cell
A ripple effect is expected on the new antibacterial discovery using “in silico” cells
Featured as a journal cover paper of Molecular BioSystems
A research team of Distinguished Professor Sang Yup Lee at KAIST recently constructed an in silico cell of a microbial pathogen that is resistant to antibiotics and developed a new drug targeting method that could effectively disrupt the pathogen"s growth using the in silico cell.
Hyun Uk Kim, a graduate research assistant at the Department of Chemical and Biomolecular Engineering, KAIST, conducted this study as a part of his thesis research, and the study was featured as a journal cover paper in the February issue of Molecular BioSystems this year, published by The Royal Society of Chemistry based in Europe.
It was relatively easy to treat infectious microbes using antibiotics in the past. However, the overdose of antibiotics has caused pathogens to increase their resistance to various antibiotics, and it has become more difficult to cure infectious diseases these days.
A representative microbial pathogen is Acinetobacter baumannaii. Originally isolated from soils and water, this microorganism did not have resistance to antibiotics, and hence it was easy to eradicate them if infected. However, within a decade, this miroorganism has transformed into a dreadful super-bacterium resistant to antibiotics and caused many casualties among the U.S. and French soldiers who were injured from the recent Iraqi war and infected with Acinetobacter baumannaii.
Professor Lee’s group constructed an in silico cell of this A. baumannii by computationally collecting, integrating, and analyzing the biological information of the bacterium, scattered over various databases and literatures, in order to study this organism"s genomic features and system-wide metabolic characteristics. Furthermore, they employed this in silico cell for integrative approaches, including several network analysis and analysis of essential reactions and metabolites, to predict drug targets that effectively disrupt the pathogen"s growth. Final drug targets are the ones that selectively kill pathogens without harming human body.
Here, essential reactions refer to enzymatic reactions required for normal metabolic functioning in organisms, while essential metabolites indicate chemical compounds required in the metabolism for proper functioning, and their removal brings about the effect of simultaneously disrupting their associated enzymes that interact with them.
This study attempted to predict highly reliable drug targets by systematically scanning biological components, including metabolic genes, enzymatic reactions, that constitute an in silico cell in a short period of time.
This research achievement is highly regarded as it, for the first time, systematically scanned essential metabolites for the effective drug targets using the concept of systems biology, and paved the way for a new antibacterial discovery. This study is also expected to contribute to elucidating the infectious mechanism caused by pathogens.
"Although tons of genomic information is poured in at this moment, application research that efficiently converts this preliminary information into actually useful information is still lagged behind. In this regard, this study is meaningful in that medically useful information is generated from the genomic information of Acinetobacter baumannii," says Professor Lee. "In particular, development of this organism"s in silico cell allows generation of new knowledge regarding essential genes and enzymatic reactions under specific conditions," he added.
This study was supported by the Korean Systems Biology Project of the Ministry of Education, Science and Technology, and the patent for the development of in silico cells of microbial pathogens and drug targeting methods has been filed.
[Picture 1 Cells in silico]
[Picture 2 A process of generating drug targets without harming human body while effectively disrupting the growth of a pathogen, after predicting metabolites from in silico cells]
2010.04.05 View 14603 -
Prof. Sang-Yup Lee Founding Member of Board of Editors of mBop
Prof. Sang-Yup Lee of the Department of Chemical and Biomolecular Engineering at KAIST has been appointed as one of the founding board of editors of the mBio which will be launched next year, the university reported on Friday (Nov. 20).
mBio is the American Society for Microbiology"s first all-online, open access journal which will be launched in next May. According to the mBio website, the journal"s scope "will reflect the enormity of the microbial world, a highly interconnected biosphere where microbes interact with living and non-living matter to produce outcomes that range from symbiosis to pathogenesis, energy acquisition and conversion, climate change, geologic change, food and drug production, and even animal behavioral change."
Prof. Lee, LG Chem Chair Professor, is currently the Dean of the College of Life Science and Bioengineering and director of the Center for Systems and Synthetic Biotechnology. He received his B.S. in Chemical Engineering from Seoul National Univeristy in Korea and his M.S. and Ph.D. in Chemical Engineering from Northwestern University.
As of September 2009, he has published 298 journal papers and has more than 440 patents either registered or applied. Also, he has published 47 books/book chapters, "Systems Biology and Biotechnology of Escherichia Coli" being the latest.
His research interests are systems biology and biotechnology, industrial biotechnology, metabolic engineering, synthetic biology and nanobiotechnology. In particular, he has pioneered systems metabolic engineering, which integrates systems biology with metabolic engineering, for the development of micropoganisms possessing superior properties for industrial applications.
2009.11.20 View 11595 -
Prof. Yu Wins Sidney Stein International Award
Prof. Jin Yu of the Department of Materials Science and Engineering won the Sidney J. Stein International Award at the plenary session of the International Microelectronics and Packaging Society (IMAPS) held in San Jose, the United States, on Nov. 3.
The Sidney Stein International Award recognizes an individual who is regarded as providing significant international technical and/or leadership contributions to the microelectronics packaging industry, while participating and demonstrating support of IMAPS international activities to enhance the electronics packaging profession.
The International Microelectronics And Packaging Society is the largest society dedicated to the advancement and growth of microelectronics and electronics packaging. It offers chapters around the globe, creating global networks of more than 4,000 members in the United States and an additional 4,000 members throughout Europe and Asia. Prof. Yu currently serves as the chairman of its Asia League Chapter and the Korean Microelectronics and Packaging Society.
2009.11.20 View 11436 -
KAIST, Microsoft Research to Set up Research Collaboration Center
KAIST, Korea"s premier institution for science and technology research and education, and Microsoft Research (MSR), the research arm of Microsoft Corp, signed a memorandum of understanding (MOU) to establish a joint research collaboration center in Korea on Oct. 20.
The research collaboration center to be located at the KAIST campus in the Daedeok science and technology town 150 kilometers south of Seoul will be dedicated to promoting joint researches, curriculum innovation, talent fostering and academic exchange in the Asian region.
The MOU signing ceremony at the Westin Chosun Hotel in Seoul was attended by President Nam-Pyo Suh and Vice President Soon-Heung Chang from KAIST, and Craig Mundie, Chief Research and Strategy Officer of Microsoft Corp, and Hsiao-Wuen Hon, Managing Director of MSR Asia from Microsoft.
“We are excited to be working so closely with Microsoft Research,” KAIST President Suh said. “This is the first of many alliances we hope to establish with the world’s industrial leaders that will enable us to resolve some of the toughest problems in computer science and accelerate the next generation of innovation in computing technology and its application in other scientific researches.”
Dr. Hon said: “For over 10 years, Microsoft Research has been committed to working with leading universities throughout Asia to spur computer science research and to strengthen Asia’s knowledge economies by helping foster their capabilities. The Microsoft-KAIST Research Collaboration Center demonstrates our continued efforts to strengthen relations with universities in Korea and build new partnerships with academia here.”
In the last three years, Microsoft Research and KAIST have engaged in close collaboration through research projects, student support programs, and various academic exchange activities. One of the major projects was to construct software development library specifically dedicated to systems biology. A number of excellent students from KAIST participated in the internship program at Microsoft Research in Beijing, China and Redmond, United States.
The establishment of the Microsoft-KAIST research collaboration center will bring the collaborative relations between KAIST and MSR to a new level. The center will provide a platform which unites the innovative minds of KAIST and Microsoft Research to develop technologies that will impact the way people live, learn, work, and play, a KAIST spokesman said.
2008.10.30 View 15947 -
International Science Journal Spotlights Korean Biotechnology
Biotechnology Journal published by German-based Wiley-VCH, one of the world"s major scientific and technical publishers, devoted its entire special edition for May to biotechnology in Korea.
The monthly journal"s special issue was planned by KAIST Professor Sang-Yup Lee of the Chemical and Biomolecular Engineering Department who is one of the journal"s two editors-in-chief.
The special issue outlines the current status and future prospect of biotechnology in Korea, and presents five review papers and eight original papers by leading Korean biotech researchers to showcase recent developments in Korean biotechnology. Among these papers, a review by Dr. Byung-Hwan Hyeon and his colleagues describes in detail the Korean biotechnology strategies represented by "Bio-Vision 2016," and another by Dr. Ji-Hyun Kim and his collaborators presents recent progress in microbial genome projects in Korea.
In the editorial of the journal, Prof. Lee said, "Heavy industry and IT industry have been the two drivers of Korean economic growth. Korea is now considering biotechnology as its next generation growth engine."
Underscoring the growing importance of fusion research, he mentioned that integration of biotechnology with information technology and nanotechnology is advancing rapidly in Korea. Another special edition of Biotechnology Journal focusing on these exciting biotech developments in Korea is planned for the future.
2008.05.20 View 12855 -
World Micromachine Summit to Open in Daejeon
The 2008 World Micromachine Summit will be held at Hotel Riviera in Daejeon for a four-day run from April 30, drawing worldwide industrial and academic leaders in the micro-nano-technology (MNT).
Organizers say that 76 delegates and 56 observers from 19 countries and regions will take part in this year"s Micromachine Summit. Prof. Cho Young-ho of the Department of Bio & Brain Engineering of KAIST will play host to the annual event.
Participants will discuss the progress of micro-nano-technology in each country and region development of national policies in this area. The Summit was first organized in 1995 by the Micromachine Center of Japan with representatives from 10 countries participating. They were Australia, Canada, Germany, Italy, Japan, the Netherlands, Switzerland, the United Kingdom, and the United States.
Korea was first invited to the conference in 1999. Since then, Korea has played an active role in promoting technological exchanges among nations and has conducted presentations and discussions on major technological breakthroughs.
During the four-day run, each delegation will outline their country"s policies and strategies and present local features on focused areas including this year"s main theme, "Micromachine towards Technology Convergence Era."
The gathering will offer a valuable opportunity for the participants to exchange and collect information on the current state of the MNT, as well as providing a forum for worldwide networking of leaders in the area.
2008.04.29 View 12136 -
Maximum Yield Amino Acid-Producing Microorganism Developed with use of System Biotechnology
Maximum Yield Amino Acid-Producing Microorganism Developed with use of System Biotechnology
A team led by Sang-Yup Lee, a distinguished professor of Chemical and Biomolecular Engineering and chair professor of LG Chemical, has succeeded in developing maximum yield L-valine-producing microorganism by using System Biotechnology methods. The research results will be published at the April fourth week (April 23 - 27) edition of the Proceedings of the National Academy of Sciences (PNAS) of the USA.
Prof. Lee’s team has developed maximum yield amino acid-producing microorganism (target substance of L-valine, an essential amino-acid) by using microorganism E cell system and simulation methods.
His team produced initial producing microorganism by selectively operating necessary parts in colon bacillus genome and excavated preliminary target gene which is to newly be operated through transcriptome analysis using DNA chips. Then they performed a great amount of gene deletion experiment on computer by using MBEL979, E-cells of colon bacillus, and excavated secondary engineering targets. And they finally succeeded in developing maximum yield valine-producing microorganism that can extract 37.8 grams of valine from 100 grams of glucose by applying experiment results to the actual development of microorganism so as to achieve the optimization of metabolic flux in cells,
Prof. Lee said, “Since successfully used for the development of microorganism on a systematic system level, system biotechnology methods are expected to significantly contribute to the development of all biotechnology-relevant industries. At the beginning, we had huge obstacles in fusing IT and BT, but my team mates cleverly overcame such obstacles, hence I’m very proud of them.” The producing microorganism and its developing methods are pending international applications (PCT).
2007.04.26 View 13579 -
A doctorate of Mechanical Engineering Named Recipient of Best Student Paper Award at International Society
Seung-Min Ryu, a doctorate of Mechanical Engineering under the supervision of Professor Dong-Yul Yang, has been named as a recipient of the best student paper award of the Society for Information Display (SID).
The title of the paper is ‘the study on the fabrication of super-high resolution cathode separators by X-ray lithography processes’. He proposed at this paper the fabrication of 12 micron-thick cathode separators, which can fabricate further delicate separators than the current 50 micron-thick commercial PDP separators, thereby significantly improving the resolution of PDPs in the future.
Ryu will make an oral presentation on this paper and win the award at the SID conference, which will take place in the U.S. for six days from May 20.
2007.04.23 View 14270 -
Gold prize for Sungkoo Yeo and silver prize for Youngsik Kim at 'Samsung Electrics paper contest'
Gold prize for Sungkoo Yeo and silver prize for Youngsik Kim at ‘Samsung Electrics paper contest’
Sungkoo Yeo, doctorate student at the division of Electrical Engineering, and Youngsik Kim, doctorate students at the division of Mechanical Engineering, won gold and silver prizes respectively at ‘the 2nd Inside edge paper contest’ organized by Samsung Electronics.
Yeo, under the supervisory of Professor Youngse Kwon, won the glory of gold prize in recognition of his highly evaluated researches in the fields of silicon-based micro mold manufacturing technologies and fine shaping technologies revealed by his paper of ‘"Fabrication of Microlens array Using PDMS Replica Molding and Oxidized Porous Silicon Bulk Micromachining’.
Kim, under the supervisory of Professor Seungwoo Kim, also won the silver prize for his research performances over the thickness pattern measuring technologies of transparent thin film coated on the pattern of an opaque metal in the field of optical technology unveiled by his paper of "Dispersive white-light interferometry for in-line inspection of thin-film layers on patterned structures".
Inside Edge paper contest is an academic paper contest organized by Samsung Electronics to reveal the fresh ideas and potential technologies of the young talented.
2006.11.27 View 15213