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Successful Development of Excavation System of Biomarkers containing Protein Decomposition Control Enzyme Information
A Korean team of researchers successfully developed a biomarker excavation system named E3Net that excavates biomarkers containing information of the enzymes that control the decomposition of proteins. The development of the system paved the possibility of development of new high quality biomarkers.
*Biomarker: Molecular information of unique patterns derived from genes and proteins that allow the monitoring of physical changes from genetic or environmental causes.
Professor Lee Kwan Soo’s team (Department of Biological Sciences) composed of Doctorate candidate Han Young Woong, Lee Ho Dong Ph.D. and Professor Park Jong Chul published a dissertation in the April edition of Molecular and Cellular Proteomics. (Dissertation Title: A system for exploring E3-mediated regulatory networks of cellular functions).
Professor Lee’s team compiled all available information of the enzyme that controls protein decomposition (E3 enzyme) and successfully compiled the inter-substrate network by extracting information from 20,000 biology related data base dissertations. The result was the development of the E3Net system that analyzes the related cell function and disease.
Cells have a system that produces, destroys, and recycles proteins in response to the ever changing environmental conditions. Error in these processes leads to disease.
Therefore finding the relationship between E3 enzymes that control the decomposition of proteins and the substrates will allow disease curing and prevention to become much easier. E3 enzyme is responsible for 80% of the protein decomposition and is therefore predicted to be related to various diseases.
However the information on E3 enzyme and inter-substrate behavior are spread out among numerous dissertations and data bases which prevented methodological analysis of the role of the related cells and characteristics of the disease itself.
Professor Lee’s team was successful in creating the E3Net that compiled 2,201 pieces of E3 substrate information, 4,896 pieces of substrate information, and 1,671 pieces of inter-substrate relationship information. This compilation allows for the systematic analysis of cells and diseases.
The newly created network is 10 times larger than the existing network and is the first case where it is possible to accurately find the cell function and related diseases.
It is anticipated that the use of the E3Net will allow the excavation of new biomarkers for the development of personalized drug systems.
The research team applied the E3Net to find tens of new candidate biomarkers related to the major modern diseases like diabetes and cancer.
2012.05.30 View 14042 -
KAIST hosts the first Can Satellite (Cansat) competition
Figure: The cansat is sent up into the air using a balloon and then separated at a certain height. The cansat slowly descends and sends terrestrial observation or atmospheric information back to earth.
KAIST will host the first ever Cansat Competition Korea, in which students from different age groups can participate in building and testing the performance of their custom satellites.
The Satellite Technology Research Center (SaTReC) at KAIST announced that it will take applications for the Cansat Competition Korea until May 25th. A cansat is a can-sized educational satellite that contains the basic elements of a real satellite. It is fired up to a few hundred meters in the air using balloons or small rockets and then separated like a real satellite, collecting data and sending the information back to earth. Cansat competitions are regularly held in the United States or Europe, where they have advanced space development programs, but this is the first time this competition will be held in Korea.
The competition caters to different age groups through a cansat experience science camp for elementary and middle school students and a cansat competition for high school and college students.
The science camp will be held from August 7th to 9th at KAIST and Sejong City and will include satellite education, visits to space development centers (KAIST Satellite Technology Research Center and the Korea Aerospace Research Institute), hand-on experience with basic cansat kits, and other various programs.
The science camp will consist of a maximum of 20 teams comprised of students from fifth to ninth grade. Each team will have an advisory teacher and 3 to 4 students and can apply for the competition at no cost.
The cansat competition will test high school and college students on their personally designed and built can satellites along with the creativity of their mission and developmental outcome.
The preliminary review will choose a maximum of 15 teams, while the secondary review will select the 5 teams that will make the final competition based on their design presentation. On August 9th, these 5 teams will be evaluated on their technical ability, mission capacity and presentation skills. The winning team will be given the KAIST presidential award along with a trophy and prize money.
Doctor Park from KAIST SaTReC explained that countries with advanced space technology actively support cansat competitions to expand the base of the field. He emphasized Korea’s need for regular cansat competitions to actively promote potential space researchers.
More information on the competition can be found on the homepage (http://cansat.kaist.ac.kr) or at the KAIST SaTReC (042-350-8613~4)
2012.05.14 View 12862 -
Korea's First MOU between a University Education Volunteer Work Group and Local Government
- 200 Adolescents from Yuseong-gu to Receive Education Community Services
Midam Scholarship committee which is composed of KAIST"s students and graduates, will draw up a contract that states that it will work together with the Yuseong-gu municipality for the development of the district education services on the 14th at the Yuseong-gu office.
Both sides will together ▲mentor the local students, ▲cooperate to run and develop creative programs, ▲exchange work for the development of the KAIST Midam Scholarship Committee, ▲conduct various other projects.
From now, the Midam Scholarship Committee will teach about 200 students in Yuseong-gu. The drawing of this contract has much meaning in that it is the first of its kind.
The Midam Scholarship Committee was founded on 2009 by students in KAIST to teach math, english, and science to students from families with low income levels.
This committee has made educational pacts with middle and high schools located in Daejeong such as Chungnam High School and Beobdong High School, and has not only taught these students but also has given scholarships to the selected students.
On one hand, the Midam Scholarship Committee has also supported 10 students in KAIST who were in need with 300000won each on the 6th. This fund was raised through the donations of alumni and mentoring projects.
The Midam Scholarship Committee has been recognized for its positive impacts on the society and has received an award from the Yuseong-gu municipality office.
2012.05.10 View 9539
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Professor Kyung Wook Baek Wins the Best Thesis Award at the 2012 Pan-Pacific Microelectronic Symposium
Prof. Kyung Wook Baek from KAIST"s material science department has won the Best Thesis Award at the 2012 Pan-Pacific Microelectronic Symposium.
The title of this thesis was "Recent Advances in Anisotropic Conductive Adhesives Technology : Materials and Processes". Prof Baek had the honor of having his thesis be appointed the best thesis of the symposium.
This thesis includes his 15 years of research on ACAs which are a key element of display and semiconductor packaging technology.
Prof. Baek"s research results has been recognized as incredibly innovative in the field of ACAs and ultrasonic connection devices. This thesis has been recognized as setting the foundation for commercialization by professionals from all over the world at the symposium.
Prof. Baek has announced two innovative technologies on ACAs at the symposium.
One is a technology that merges the nanofiber technology with the ATAs. This technology was highly applauded for overcoming the problem of electric connection in micro-pitch display semiconductors, and successfully applying this to electronic packaging materials.
Currently, commercialization process based on the patent is ongoing. It is expected that we will be able to take hold of the entire market once the commercialization succeeds.
The other technology was to improve the liability and overcome the limits of the current flow in ACAs through the use of solder molecules. This is also undergoing commercialization process for use in mobile electronic devices.
Together with this, Prof.Baek has reported an innovative case where the original heat compression process was replaced with a new ultrasonic process. This discovery is deemed to be extremely great due to its implications in replacing all heat compression systems. This too will soon be commercialized
Prof.Baek has played a crucial role in the development of electronic packaging material and processing technology. He has written the largest number of theses in this area, and has proven himself to be the world"s best through winning this award.
2012.05.10 View 10940
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KAIST Midam Institute Gives Donations Raised by Students
Midam Association which is consisted of students from KAIST (representatives Neung-in Jang and Minkyu Jin) has donated 300thousand won per person to ten KAIST students who are in need totaling a 3million won of donation. This donation was created through the mentoring activities of the members and donations from alumni and alumni corporations.
Midam Association which was created on July of 2009 teaches math, science, and English to children from lesser off families. It started as a club created by undergraduate students and has now turned into an NGO where other local volunteers could participate.
Currently as of March, there are ten schools including Bubdong Middle School, Jeon-min Middle School, Chungnam High School, and Jeonmin High School that have a pact with the Midam Association. The association has been conducting education assistance as well as giving donations to students in need.
Last January, UNIST has benchmarked KAIST"s Midam Association and has started free education volunteer programs in association with Ulsan city.
On the other hand, Midam Association of KAIST has been awarded a Certificate of Recognition by the Municipality of Yuseong-gu, Daejeon in recognition of their deed.
2012.05.10 View 8933
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New concept 'mole game' robot developed
A new game robot concept developed by KAIST researchers came in first place at a world-renowned virtual reality exhibition, despite being the first ever entry by a Korean team.
Professor Lee Woohun’s team from the Department of Industrial Design at KAIST won the first-place award of ‘Gran Prix du Jury’ at the famous virtual reality exhibition, Laval Virtual 2012, which was held between March 28th and April 1st, with the mole game robot, ‘MoleBot’.
MoleBot can be enjoyed in a completely physical environment unlike other virtual reality games and allows interaction between the virtual world and reality. Such imaginative interaction attracted numerous spectators during the exhibition.
The MoleBot table consists of approximately 15,000 small cubes, and as the object inside the table moves, the cubes slide as if a mole is inside. By using a joystick, users can enjoy physical interaction with the table and a wide range of games.
The MoleBot can also be operated with hand gestures using ‘Kinect’, a motion sensing input device developed by Microsoft, making it possible to enjoy games as if playing with a pet.
Professor Lee’s team came up with the project from a simple idea: ‘What if moles lived inside the table?’
The team first created a table that would hold and allow the movement of the cubes, and then placed a plastic mold underneath it with a layer of spandex in between to lessen the friction, allowing smooth and lifelike movement.
The mold contains magnets that allow the accurate delivery of mechanical movement. After two years of continued additional research, MoleBot was released to the world.
In the acceptance speech, Professor Lee said, ‘It is rare for a design team to win first place in an engineering exhibition’ and that ‘to achieve such a feat, the MoleBot’s technological creativity and artistic completeness became one’.
Professor Lee also said that ‘this concept of creating an interactive world on a table could potentially become a new game interface’ and that he would research on applying this MoleBot technology to different fields such as human-computer interaction, architecture, interior, and clothing.
Laval Virtual is a world-renowned exhibition that displays cutting edge technologies in the field of virtual reality. This year was the 14th exhibit, and over 10,000 people participated in it. The exhibition gives out 12 awards, one per field, and Professor Lee’s team won the highest award.
2012.05.07 View 12159 -
Biomimetic reflective display technology developed
Professor Shin Jung Hoon
The bright colors of a rainbow or a peacock are produced by the reflection and interference of light in transparent periodic structures, producing what is called a structural color. These colors are very bright and change according to the viewing angle. On the other hand, the wings of a morpho-butterfly also have structural colors but are predominantly blue over a wide range of angles. This is because the unique structure of the morpho-butterfly’s wings contains both order and chaos.
Professor Shin Jung Hoon’s team from the Department of Physics and the Graduate School of Nanoscience and Technology at KAIST produced a display that mimics the structure of the morpho-butterfly’s wings using glass beads.
This research successfully produced a reflective display (one that reflects external light to project images), which could be used to make very bright displays with low energy consumption. This technology can also be used to make anti-counterfeit bills, as well as coating materials for mobile phones and wallets.
The structure of the morpho-butterfly’s wings seems to be in periodic order at the 1-micrometer level, but contains disorder at the 100-nanometer level. So far, no one had succeeded in reproducing a structure with both order and disorder at the nanometer level.
Professor Shin’s team randomly aligned differently sized glass beads of a few hundred nanometers to create chaos and placed a thin periodic film on top of it using the semiconductor deposition method, thereby creating the morpho-butterfly-like structure over a large area.
This new development produced better color and brightness than the morpho-butterfly wing and even exhibited less color change according to angle. The team sealed the film in thin plastic, which helped to maintain the superior properties whilst making it more firm and paper-like.
Professor Shin emphasized that the results were an exemplary success in the field of biomimetics and that structural colors could have other applications in sensors and fashion, for example.
The results were first introduced on May 3rd in Nature as one of the Research Highlights and will be published in the online version of the material science magazine, Advanced Materials.
This research was jointly conducted by Professor Shin Jung Hoon (Department of Physics / Graduate School of Nanoscience and Technology at KAIST), Professor Park NamKyoo (Department of Electrical and Computer Engineering at Seoul National University), and Samsung Advanced Institute of Technology. The funding was provided by the National Research Foundation of Korea and the Ministry of Education, Science and Technology as part of the World Class University (WCU) project.
Figure 2. The biomimetic film can express many different colors
Figure 3. The biomimetic diplay and a morpho-butterfly
2012.05.07 View 16210 -
The output of terahertz waves enhanced by KAIST team
KAIST researchers have greatly improved the output of terahertz waves, the blue ocean of the optics world. This technology is expected to be applied to portable X-ray cameras, small bio-diagnostic systems, and in many other devices.
Professor Ki-Hun Jeong"s research team from the Department of Bio and Brain Engineering used optical nano-antenna technology to increase the output of terahertz waves by three times.
Terahertz waves are electromagnetic waves with frequencies between 100GHz to 30THz. They are produced when a femtosecond (10^-15 s) pulse laser is shone on a semiconductor substrate with photoconduction antennas, causing a photocurrent pulse of one picosecond (10^-12 s). Their long wavelengths, in comparison to visible light and infrared rays, give terahertz waves a high penetration power with less energy than X-rays, making them less harmful to humans.
These qualities allow us to see through objects, just as X-rays do, but because terahertz waves absorb certain frequencies, we can detect hidden explosives or drugs, which was not possible with X-rays. We can even identify fake drugs. Furthermore, using the spectral information, we can analyze a material"s innate qualities without chemical processing, making it possible to identify skin diseases without harming the body. However, the output was not sufficient to be used in biosensors and other applications.
Prof. Jeong"s team added optical nano-antennas, made from gold nano-rods, in between the photoconduction antennas and optimized the structure. This resulted in nanoplasmonic resonance in the photoconduction substrate, increasing the degree of integration of the photocurrent pulse and resulting in a three times larger output.
Hence, it is not only possible to see through objects more clearly, but it is also possible to analyze components without a biopsy.
Professor Jeong explained, "This technology, coupled with the miniaturization of terahertz devices, can be applied to endoscopes to detect early epithelial cancer" and that he will focus on creating and commercializing these biosensor systems.
This research was published in the March issue of the international nanotechnology journal ACS Nano and was funded by the Korea Evaluation Institute of Industrial Technology and the National Research Foundation of Korea.
Figure: Mimetic diagram of a THz generator with nano-antennas
2012.04.29 View 13778 -
NPKI Launch Workshop Held
Molecular Physics Department Expected to Have ‘NPKI’ Launch Workshop
- Numerous physicists tracking the god-particle ‘Higgs’ attending-
The NPKI: New Physics at Korea Institute which was launched a six day workshop in Shinla Hotel, Seoul with 50 physicists from in and out of the country.
The event started with Professor Gi Woon Choi’s welcoming speech. A heated debate with the theme ‘Top physics and electroweak symmetry breaking in the LHC era’ took place in the event.
NPKI was created this year to search into the most fundamental workings of nature, research the meaning of such mechanisms, and share this knowledge with not only the general public, but also with the teenagers who wish to someday become physicists.
Professor Gi Woon Choi from KAIST, Professors Byoung Wong Ko and Eung Jin Jeon from the Advanced Science Institute, and more are participated in this workshop from Korea.
From abroad, world renowned professors such as Prof. Csaba Csaki from Cornell, Prof. Christophe Grojean from CERN, Prof. Erez Etzion from Tel Aviv University of Israel, and Prof. Zoltan Ligeti from UC Berkley participated in this event.
The ‘Seeds Program’ took place. This is a program where 20 high school and middle school students aspiring to become physicists were able to attend the work shop without any due fee to experience the world of physicists.
The students chosen for the program were able to attend the conference to watch debates of real physicists as well as experience the academic lives of physicists. They were also able to attend the lecture conducted by Prof. Gilad Perez from CERN and were granted question and answer sessions as well.
The workshop was hosted by NPKI, and sponsored by Shinla Hotel, BK21 KAIST Physics, department of physics of KAIST, department of physics in Seoul National University, the Advanced Science Institute, and the Center for Quantum Spacetime
2012.04.04 View 14078
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Inexpensive Separation Method of Graphene Developed
The problem with commercializing graphene that is synthesized onto metals over a wide area is that it can not be separated from the metal. However, a groundbreaking separation technology which is both cheap and environment friendly has been developed.
Prof. Taek soo Kim and Prof. Byung Jin Cho"s research teams have conducted this research under the support of the Global Frontier program and Researcher Support Program initiated by The Ministry of Education and Science and Korea Research Foundation. The research results have been posted on the online news flash of Nano Letters on februrary 29th. (Thesis title: Direct Measurement of Adhesion Energy of Monolayer Graphene As-Grown on Copper and Its Application to Renewable Transfer Process)
The research has generated exact results on the interfacial adhesive energy of graphene and its surface material for the first time. Through this, the catalyst metal are no longer to be used just once, but will be used for an infinite number of times, thereby being ecofriendly and efficient.
Wide area graphine synthesized onto the catalyst meatal are used in various ways such as for display and for solar cells. There has been much research going on in this field. However, in order to use this wide area graphene, the graphene must be removed from the catalyst metal without damage.
Until now, the metal had been melted away through the use of chemical substances in order to separate the graphene. However, this method has been very problematic. The metal can not be reused, the costs are very high, much harmful wastes were created in the process of melting the metals, and the process was very complicated.
The research teams of Professors Taek Su Kim and Byung Jin Cho measured the interfacial adhesive energy of the synthesized graphene and learned that it could be easily removed.
Also, the mechanically removed graphene was successfully used in creating molecular electronic devices directly. This has thus innovatively shortened the graphene manufacturing process. Also, it has been confirmed that the metalic board can be reused multiple times after the graphene is removed. A new, ecofriendly and cost friendly method of graphene manufacturing has been paved.
Through this discovery, it is expected that graphene will become easier to manufacture and that the period til the commercialization date of graphene will therefore be greatly reduced
Prof. Cho stated " This reserach has much academical meaning significance in that it has successfully defined the surfacial adhesive energy between the graphene and its catalyst material and it should receive much attention in that it solved the largest technical problem involved in the production of graphene.
2012.04.04 View 15483
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New Era for Measuring Ultra Fast Phenomena: Atto Science Era
Domestic researchers successfully measured the exact status of the rapidly changing Helium atom using an atto second pulse. Thanks to this discovery, many ultrafast phenomena in nature can now be precisely measured. This will lead to an opening of a new "Atto Science" era.
Prof. Nam Chang Hee led this research team and Ph.d Kim Kyung Taek and Prof. Choi Nak Ryul also participated in this research. They have conducted the research under the support of the Researcher Support Program initiated by The Ministry of Education and Science and Korea Research Foundation. The research result was published in the prestigious journal "Physical Review Letters" on March 2nd. (Title: Amplitude and Phase Reconstruction of Electron Wave Packets for Probing Ultrafast Photoionization Dynamics)
Prof. Nam Chang Hee"s research team used atto second pulse to measure the ultrafast photoionization.
His team used atto second X-ray pulse and femto second laser pulse to photoionize Helium atoms, and measure the wave speed of the produced electron to closely investigate the ultrafast photoionization process.
Atom"s photoionization measurement using an atto second pulse was possible using the research team"s high-energy femto second laser and high-performance photo ion measurement device. This research team succeeded in producing the shortest 60 atto second pulse in the world using high-harmonic waves.
The research team used high-power femto second laser to produce atto second high-harmonic pulse from argon gas, used this to photoionize Helium atoms, and measured the ultrafast photoionization of the atoms.
Prof. Nam Chang Hee said, "This research precisely measured the exact status of rapidly changing Helium atoms. I am planning to research on measuring the ultrafast phenomena inside atoms and molecules and controlling the status of the atoms and molecules based on the research result."
2012.04.04 View 11551
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Undergraduate Research Program, Putting Wings on Undergraduate"s Dreams
KAIST held the 2011 URP Research Result Presentation in the Creative Learning Center on the 17th. Four students Jae Gyung Seo, Tran An Tu, Gun Sik Ahn, and Gyung Ryul Bong have been chosen as the grand prize winners.
The grand prize winners receive 3.5million won to allow them to participate in an international academic conference. The URP program is the first of its kind in Korea and has been benchmarked from MIT’s UROP(Undergraduate Research Opportunity Program).
The school selects 60 individual and 20 team research projects for undergraduates twice a year and provides mentorship as well as financial support.
Students signing up for the URP are to submit research plans and are then chosen through looking at these documents. Students receive 6 months of research funds and are to work under a professor and TA in groups of 2 to 3 or individually.
The URP program which is funded by the Ministry of Science and Technology has settled in successfully and has been expanded to the entire country.
The head of the R&D team, Yong Jae Sung, stated, “The number of research plans have been 154 in 2008, 189 in 2009, 220 and 251 respectively in 2010 and 2011. It’s continuously rising. And over 80% of responses on satisfaction surveys have replied that students were satisfied. It is very popular among undergraduates.“
Student Sang Yeon Cho has also said, “I was able to research on everything that I wanted under funding of the school and the guidance of renowned professors thanks to the URP program.”
To Seul Gi Lee, a graduate student for the electrical engineering department who has developed the wearable sleeping pattern analysis system, URP is an especially special program.
She said, “I successfully researched in the wearable health care field as my URP research material in 2006 when I was in my junior year. I made second place. After this, I have continued my research in this field on SoC(System on Chip) for wearable healthcare in graduate school and will be receiving my doctorate degree on the 24h.”
Doctor Seul Gi Lee has been recognized in the field of wearable healthcare for her research and has been hired as a researcher in the Holst Centre which is a national research center funded by the Netherlands’ government. She will continue to research on measuring and analyzing biological readings.
2012.04.04 View 11205