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Creation of Synthetic Antibodies: Professor Hak Seong Kim
Synthetics antibodies which can replace antibodies from humans used as ingredients of medicines have been developed. It can increase the costs to 1/100 of the current costs and is much easier to develop. It is expected that the development period will be shortened from 10 years to 5.
Prof. Hak Seong Kim from the Biology department of KAIST conducted a joint research with Prof. Dong Seob Kim to reconstruct proteins and has succeeded.
The synthetic antibody displays much strength in terms of its productivity, structural formation, and bonding capability, and is thus regarded as an ideal protein. It can replace the antigens that are currently in use. It is expected that Korea will therefore be able to lead the world market for protein medicines which is a 192trillion won industry.
The original antibody has been used for not only treating diseases, but also for various other applications in the fields of medical sciences and biology. However, it is produced through a very complex process involving the incubation of animal cells, and is therefore very expensive. Also, most antibodies are already patented by more developed countries, so a high royalty fee must be paid.
Because of this, many countries including Korea has been concentrating on developing biosimilars copying the antibody medicines for which the patents have already expired. This causes Korea to be behind in the development of antibody protein pharmaceuticals.
Prof. Kim’s research team has focused on the face that the protein existing in some eels are not antibodies but functions as one, and has been successful in developing a synthetic antibody.
The synthetic antibody can be mass produced from the colon bacillus, which allows it to be produced at 1/100 the original cost. It is in a module structure which allows the structuring of the antibody into the desired structure, enabling it to be developed into a protein-based medicine within 5 years.
Together with this, the coherence with the important antigens can be easily controlled, thus allowing for highly effective treatments, less side-effects, high security regarding heat and pH, and the immunogen levels being negligeable. This suggests a very high rate of the antibody being converted into a protein based medication.
The synthetic antibody technology has been tested as a sample for the cure for lung diseases and rheumatism and has been proven to be appropriate. Animal testing will be conducted soon.
Prof Kim said “The original antibodies had a small area allowing the bonding with antibodies, creating barriers for raising bonding strength and structuring. The newly created antibody carries only the strengths and will become a new protein based medicine purely created by Korean technology to replace the antibodies currently used in medications.”
Furthermore, he added that, “The synthesized antibody structuring and designing technology will be widely used in the areas of detecting, diagnosing, and analyzing diseases.”
At the same time, this research result has been published in the Feb 10th issue of the PNAS, and has been supported by the future promising pioneer business program held by the Ministry of Education and Technology.
2012.04.04 View 12252 -
Paving the Way to Next Generation Display
A new type of LCD that does not require polymer orientation films has been developed by researchers within the country. This technology will enable the creation of thiner and higher definition display.
Prof. Hee Tae Jung form KAIST’s biochemical engineering department led the research and Hyun Soo Jung, Hwan Jin Jeon doctoral students (1st co-authors), Doctor Yun Ho Kim from Korea Chemistry Research Center, and Prof. Shin Woong Kang from Jeon Buk University ( co-author) have participated in this research. This research has been funded by the WCU program and middle-grade researcher support program. The results of the research has been published as the online update of ‘‘Nature Asia Materials(NPG Asia Materials)” which is a sister magazine of the world renowned academic magazine ‘Nature’.
The flat display industry is the core industry leading the 21st century’s IT industry. The LCD is the main area of research. Korea is the leader of this industry, holding more than 50% of the world market. Many technologies are combined to make the electro-optic devices of the LCD function. The most important technology, which determines the indicating element’s quality and function is the technology to align the liquid crystals in one direction.
Currently, all LCD products are created by mechanically cutting into the surface of the polymer film and orienting the liquid crystal material along these cuts. However, the creation of polymer orientation films cost much time and money, and the high temperature processes necessary to stabilize the polymers does not allow for the free selection of circuit boards, and thus does not allow for the use in flexible display.
Prof. Hee Tae Jung devised a method to orient liquid display without the use of a polymer film using ITOs. Prof. Jung’s base technology has been tested on ITOs to maintain the necessary transparency and conductivity after forming a pattern with high decomposition rates and slenderness ratios.
The technology developed by the research team can horizontally or vertically align the transparent conductors without the use of polymer orientation films. Thus, the manufacturing processes have become much shortened and the LCDs can be made in much thinner from a few micrometers to a few centimeters. Also, it has a lower functioning voltage and faster response speed, showing the prospects of a high definition ultra-fast screen display development. Furthermore, this technology can be used for any type of board, and can be adjusted to a nanometer scale. This enables for its use in LCD based flexible or multi-domain modes.
Also, the transparent conductor patterning technology devised by the research team can be used not only for displays, but also for touch panels with highly increased sensitivity.
Prof. Jung said, “It was a long desire of the industry and academia to find a way to replace the polymer orientation film. This new technology does not need any polymer orientation films, and we can still use the original boards used for LCDs. This mean a lot to the industry. Also, this technology will increase the sensitivity of the touch panels for tablet PCs and smart phones. It can be used in many areas of future electronics base technology.”
2012.04.04 View 11697
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The Australian: Asia more than competition, March 30, 2012
The Australian, the largest-selling newspaper in Australia, carried an article titled, “Asia more than competition,” an interview with Dr. Simon Marginson who is Professor of Higher Education in the Center for the Study of Higher Education at the University of Melbourne. Professor Marginson talks about the recent rise of universities in Asia, predicting that the Asian universities will eventually take up as much an equal share of importance as universities in Northwestern Europe in leading the world’s higher education within the next five to ten years. For the article, please follow the link below:
The Australian
Asia more than competition: Simon Marginson
by: John Ross
March 30, 2012 12:00AM
http://www.theaustralian.com.au/higher-education/asia-more-than-competition-marginson/story-e6frgcjx-1226309922402
2012.03.30 View 8096
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KAIST Confers Honorary Degree to CMU President Cohon
By DongJae Lee
The KAIST Herald Staff Reporter
On February 24, Dr. Jared L. Cohon, President of Carnegie Mellon University (CMU), visited KAIST to receive an honorary degree in science and technology and gave a lecture to the university’s students. Dr. Cohon is the eighth president of CMU and has held numerous other public and university positions. During his presidency, CMU has expanded globally and now takes part in joint programs around the world, including those with universities in Korea, Australia, India and Qatar. KAIST and CMU have been collaborating since 2005 in research projects, student and faculty exchange and dual degree programs. Before the 2012 Commencement Ceremony, Dr. Cohon met with The KAIST Herald and other news agencies for an interview.
The interview started with Dr. Cohon giving a brief introduction of CMU. Like KAIST, CMU has a small but special composition and is dedicated to science and technology as well as business and the fine arts. CMU, founded in 1900, is also relatively young by US standards but has nonetheless grown into a world-class university. The power behind this rapid growth can be expressed by four key values: innovation and change, problem-solving, interdisciplinary cooperation, and hard work. The slogan “My heart is in the work” clearly expresses the values of CMU.
One interesting aspect of CMU is its fine arts and business fields. While CMU is dedicated to science and technology, it also has many respected alumni in the aforementioned fields including Andy Warhol, a leading figure in pop art, and Randy Pausch, the author of The Last Lecture. CMU alumni have together won 6 Academy Awards, 22 Emmy Awards, over 100 Tony Awards and 20 Nobel Prizes.
Regarding CMU’s joint projects with KAIST, as well as student and faculty exchanges, Dr. Cohon mentioned joint Ph.D. programs in Civil and Environmental Engineering and Mechanical Engineering and a joint Master’s program in Software Engineering. Currently, the Civil and Environmental Engineering joint Ph.D. program has one participant and the Software Technology Institute joint Master of Software Engineering program has 6 participants.
Dr. Cohon mentioned that receiving an honorary degree in KAIST is a tremendous honor and that he is grateful to be recognized by such a wonderful university like KAIST.
2012.03.23 View 11481 -
KAIST placed the 5th in top 50 global universities for international patent applications
New York Times released an article, dated March 19, 2012, on the statistics of international patent applications filed by global universities during 2011, and with 103 applications published, KAIST was listed the fifth among the top 50 universities, right behind four US universities: University of California (277), the Massachusetts Institute of Technology (179), the University of Texas System (127), and Johns Hopkins University (111). A total of seven Korean universities including KAIST made the top 50 list. For the article, please check the link below:
New York Times, March 19, 2012
“U.S. Universities Retain Lead in Patent Applications”
By Christopher F. Schuetze
http://www.nytimes.com/2012/03/19/world/asia/us-universities-retain-lead-in-patent-applications.html
In addition, for the press release by the World Intellectual Property Organization, the UN agency responsible for the Patent Cooperation Treaty, on international patent filings in 2011, please click the following link:
“International Patent Filings Set new Record in 2011”
http://www.wipo.int/pressroom/en/articles/2012/article_0001.html
2012.03.21 View 10747
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A Step Closer to Ultra Slim Mobile Phone
Professor Baek Kyung Wook (department of Material Science and Engineering) succeeded in developing an ultra-thin conjugation technique that can perfectly replace the modular contact in electronic devices.
The research team developed a compound material using ultra-fine solder-adhesive film and developed the vertical ultrasonic conjugation process thereby making a reliable utra-thin conjugation.
The developed technique allowed for very thin and reliable conjugation and will be able to replace the socket type connector and is expected to revolutionize the electronic device industry.
In mobile electronic devices like the smartphone, the trend is to incorporate various functional modules like camera, display, touchscreens, etc. in addition to striving for miniaturization of the device.
Recently the problem was the fact that the number of modules within the device was increasing due to the incorporation of various functions, and consequently the volume that these modules took up increased as well, which made miniaturization almost impossible.
Professor Baek‘s team succeeded in improving upon this problem by creating a compound material that has ultra-fine solder particles that can melt to form alloy fusion with the electrode and thermosetting adhesive film that can wrap around the electrode and provide mechanical protection.
The use of this material made it possible to reduce the thickness of the connector by hundredth fold which improved electrical, mechanical properties and highly reliable.
From a processing standpoint the conventional conjugation process involved heating the mechanical block and was therefore hard to manage its production and also consumed 1000W and took up to 15 seconds.
By contrast, Professor Baek’s team’s new process uses only ultrasound to locally heat and melt the conjugation point itself thereby reducing power consumption to 100W and conjugation time to 1~5 seconds.
The technique developed by Professor Baek and Lee Ki Won Doctorate student was awarded Excellent Dissertation Award by world famous journals like the Electronic Components and Technology Conference and is being recognized worldwide.
2012.01.31 View 10806
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KAIST Ph.D Mihyun Jang Employed as Professor at Technische Universitat Graz
A Ph.D purely from Korea has been employed as a professor at Technische Universitat Graz.
This is the news of Prof.Mihyun Kang (39) who has graduated from KAIST’s mathematics department. Prof.Kang has transferred on January 2012.
KAIST explained that “it’s the first time for a mathematics Ph.D from Korea has been employed abroad.”
Technische Universitat Graz of Australia is ranked the top third university within the country. It is a global university with 1,700 students from 78 different countries out of its 11,000 students.
Prof. Kang researched mainly theories of combination including random graphing theories, analytical combination theories, and probabilistic combination theories. She has been employed as a lifetime professor through open recruitment where she competed with others through academic debates and interviews.
Technische Universitat Graz valued Prof. Kang’s research highly made her the department head of the ‘Optimization and Discrete Mathematics department’ to create an environment where she could continuously research.
Prof. Kang graduated from Jeju university majoring math educations and did her graduate studies in KAIST. She is a purely ‘Korean’ Ph.D. After her studies, she worked for Germany’s Humboldt University and Freie Universitat Berlin. In 2007, she was able to be employed as a professor in Germany, and in 2008, she was chosen as a Heisenberg fellow.
Prof. Kang who had her research achievements recognized in Germany and Austria was also offered seat as professor in Ludwig Masximilan University of Germany and Alpenadria University in Austria, but chose Technische Universitat Graz.
2012.01.31 View 12258
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Great Success!: 2011 Wearable Computer Contest
The 2011 Wearable Computer Contest (WCC) was held on the 28th and 29th of November at Seoul COEX. The WCC is hosted by KAIST and Korea Next Generation Computing Society and is an annual event.
A wearable computer allows the user to freely use the computer even a moving environment and involves the miniaturization, weight lightening to incorporate the computer into clothing. It is the fusion of IT technology and fashion and is opening new fields like entertainment, healthcare and other forms of fashion culture.
The competition selected 10 teams out of the 57 teams that applied that will participate in the finals.
The selected teams have to use smartphones to create a wearable computer that detects and uses the biorhythm of the wearer. A staff member commented that the requirement to use biorhythm reflected in many teams entering products related to health and safety, and body and entertainment.
The most notable of the products entered was the outfit that prevents bicycle accidents. The LED attached on the back shows the direction the bicycle is traveling, or if it is stopping and uses the smartphone as a camera to show the cyclist what’s going on behind him.
Other interesting products included a product that turned clothes into a movie theater. Whilst watching movies on the smartphone, sensors attached to the clothing give out vibrations, water vapor, smoke effect; essentially brining the 4D movie experience to each person.
In addition products like ▲LED jacket that turns music into light and vibration ▲a prosthetic arm using an electromyogram to move it ▲an exercise suit that detects regional exercise load and helps design a balanced exercise regime.
Kolon Industries Ltd. Provide the clothing for the finalists and the team that receives Kolon Special Award will be given the opportunity to commercialize the product.
2012.01.31 View 9295
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New LEDs: Large Spectrum of Colors
Professor Yonghun Cho has discovered that LEDs with hexagonal pyramid structures can emit various colors of light.
LEDs, which have been leading the light revolution is a light emitting element that uses the characteristics of semiconductors to emit light upon passing a current, and is being used for lighting, TV, and various signaling devices.
In general, the white LED used for lighting has to be constructed by spraying yellow fluorescent material on a blue LED or by creating a complicated circuit where various LED chips function together.
Prof.Cho’s research team discovered the fact that when a small hexagonal pyramid structure is formed on the semiconductor composing the LED and a current is passed through this, then each side, edge, and point on the pyramid assumes different energies.
Due to the energy differences, lights of bluegreen, yellow, and orange were emitted from the side, edge, and points of the pyramid, respectively. This shows the prospect of displaying white light as well as that of many other colors.
Thus, applying the nanopyramidal structure to LEDs will allow the emission of light with a large spectrum with just the flow of the current, enabling a new type of LED light emitting particles that would display various colors from a single LED chip without the use of a fluorescent material.
Also, originally, LEDs have had limitations to its efficiency because of its structural characteristics where fluorescent materials had to be sprayed on, but the nanopyramidal structures will overcome this structural barrier to create brighter light
2012.01.31 View 8192
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'Scientist-Engineer of the Month' for December: Professor Choi Joon Ho
Professor Choi Joon Ho (department of Biological Sciences) was made ‘Scientist-Engineer of December’ for his discovery of new gene (twenty-four) that helps biorhythm and proving that this gene helps control biorhythm.
Professor Choi published 100 dissertations over the past 25 years and made significant advancements in the field of molecular virus and neurobiology.
In 1995 Professor Choi uncovered the fact that the NS3 protein in C type hepatitis function as RNA helicase thereby opening the path to developing a cure for C type hepatitis; this is an international patent with Chiron corporation. The result was published in Biochemical and Biophysical Research Communications Journal and was the most domestically referred to dissertation in biological sciences in 1999.
In addition Professor Choi published in Nature magazine in 1999, a dissertation that uncovered the fact that the DNA of papillomar virus has another protein (hSNF5) that direct it apart from ordinary proteins.
In 2000~2005 Professor Choi published many dissertations in journals like Immunity, Cancer Research, Molecular and Cellular Biology, Oncogene, Journal of Virology, and etc.
Professor Choi screened over 10,000 species of pomace fly mutations and discovered the twenty-four gene that affects the biorhythm of pomace flies. He analyzed this gene further and found a new function that was different from known biorhythm mechanisms.
This research allowed a better understanding of biological clock of pomace flies and therefore was another step towards better understanding the control mechanism of human biological clock.
2012.01.31 View 10596
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Information Sharing Webzine "You'reKA"
KAIST will be opening “You’reKA” to improve communication between staff members and between KAIST family members. “You’reKA” will primarily deal with school policies, research successes, news of KAIST family members, opinions, and other on, off campus news.
“You’reKA” is a shortened form of “You are KAIST” and is a homonym of ‘Eureka’ an expression used for scientific discovery and is supposed to instill pride as KAISTians.
The webzine is set to be opened in January of this year and will showcase 5 menus: “We Ask KAIST the Way”, “KAIST Report”, “Issue Briefing”, “Opinion” and “You”.
“We Ask KAIST the Way” introduces messages from the President and Vice President of KAIST and is a corner where honest opinions regarding the university’s vision and leadership are shared. It will be run as a Q&A corner that includes major publications and comments along with interviews, external experts, and staff members.
Under the “KAIST Report” menu, there will be ‘KAIST Today’ section where up to date research and experiment successes are posted, and a ‘KAIST Yard’ where various event information and news of KAIST members are shared.
“Issue Briefing” will introduce an overall assessment of various university management policies and issues and provide a complete scan of information. “Opinion” will allow visitors to the webzine to read up on various perspectives and comments from Professors and experts on Science and Technology.
The “You” menu will introduce various stories, activities, and expertise of KAIST staff members and their families.
“You’reKA” is expected to bring the campus closer together and provide an agora of sorts where ideas can be exchanged and bring down the differences between each member of KAIST.
2012.01.31 View 8250
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Professor Lee Jae Kyu : Appointed Fellow at Association of Information Systems
Professor Lee Jae Kyu of the Graduate School of Information Media Management was made Fellow of the Association of Information Systems.
Professor Less was the Chief Editor of Electronic Commerce Research and Applications, Chairman of Asia Pacific Information System Symposium, and Chairman of Korea Academy of Management Information, in addition to Chairman of the Academy of Korea Intelligence Information System.
The ‘Electronic Commerce’ co-written by Professor Lee is being used as primary MBA textbook in many universities around the world.
Homepage : http://www.business.kaist.ac.kr/faculty/jklee/
2012.01.31 View 9811