research
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Low Cost and Simple Gene Analysis Technology Developed
Professor Park Hyun Kyu of the Department of Biology and Chemical Engineering has developed a ‘real time CPR’ using Methylene Blue (nucleic acid bonding molecule with Electro-Chemical property).
The current gene analysis being used in the field is the real time PCR (Polymerase Chain Reaction) which takes advantage of the luminescent property of the gene and therefore requires expensive machines and chemicals to run.
By contrast, the electro-chemical method is easy to use and low cost and, most importantly, it allows the machine to become small and portable.
Professor Park’s research team used the decrease in the electro-chemical signal when the Methylene Blue reacts with nucleic acid and applied this to PCR which allowed for the real time analysis of the nucleic acid amplification process.
With the result of the experiment as the basis, the team was able to perform a trial with Chlamydia trachomatis, a pathogen that causes sexually transmitted disease.
The result showed that the electro-chemical method showed the same performance level as the real time PCR, which proved that the technology can be applied to diagnosing various diseases and gene research.
2011.04.30 View 9055 -
The Irish Times: Gene link identified in ADHD, April 18, 2011
The Irish Times wrote an article on the recent research breakthrough made by a KAIST research team to identify a gene that triggers the syndrome of Attention Deficit Hyperactivity Disorder (ADHD) among children. Given the heightened attention to the syndrome across the world, the research result has received a great deal of attention not only from the academia but also from the media and public.
For the article, please visit http://www.irishtimes.com/newspaper/ireland/2011/0418/1224294910305.html. The research paper was appeared online April 17, 2011 in Nature Medicine, which will be printed in its May 2011 issue. For the paper, please click the link of http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.2330.html.
2011.04.18 View 9100
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Businessweek: How Twitter Could Unleash World Peace, April 11, 2011
A KAIST graduate scholar, Meeyoung Cha, conducted a joint study with international researchers and released a paper on the aspect of twitter as an emerging cyber arena for political and social debates and discussions. An article on the paper from Businessweek follows:
Businessweek
April 11, 2011, 9:08PM EST text size: TT
How Twitter Could Unleash World Peace
Researchers from Britain, Korea, and Germany have determined that the amount of fresh information you get on Twitter is less a matter of what you follow than whom—and who follows you
By Bobbie Johnson
On certain days, Twitter can feel like the world"s biggest, fastest echo chamber. Since we tend to follow people who are similar to us, we often see our own views reflected back—meaning a gloomy cloud of irritation can rapidly swirl into a cyclone of outrage as we hear from other people who feel as we do. A group of computer scientists have discovered that the opposite may also be true. Can Twitter be part of the solution, not merely part of the problem?
In a study to be presented at a conference in July, a team of researchers from the U.K."s University of Cambridge, Korea"s Graduate School of cultural Technology-KAIST, and Germany"s Max Planck Institute for Software Systems show how Twitter can provide users greater access to more varied political viewpoints and media sources than they might otherwise get.
The paper, called "The Media Landscape in Twitter(http://www.cl.cam.ac.uk/~jac22/out/twitter-diverse.pdf)," explains how the team made surprising discoveries when they looked into the site"s usage patterns. First they looked at who follows whom and discovered that Twitter is a highly politicized space. Then they examined patterns of tweeting and retweeting to try to understand how people receive information on Twitter—and what they might see. Their conclusion: Although Twitter is a pretty partisan space, it can offer unprecedented opportunities to break down the barriers that plague local, national, and international politics.
How? Through retweets and interaction—what the authors call "indirect media exposure." As they put it, this "expands the political diversity of news to which users are exposed to a surprising extent, increasing the range by between 60 percent and 98 percent. These results are valuable because they have not been readily available to traditional media and they can help predict how we will read news and how publishers will interact with us in the future."
If you"re interested in the way Twitter works, I recommend reading the paper, which isn"t very long. Meanwhile, let"s boil it down to a few key pieces of data and see what lessons they can teach.
Most Twitter users are political. Just over half (50.8 percent) of all Twitter users studied showed a distinct political bias in the media outlets and individuals they followed. Most of those lean to the left of the political spectrum, accounting for 62 percent of users who demonstrated some bias. Thirty-seven percent were doggedly centrist. Just 1 percent of Twitter users who showed a political preference were right-wing.
Here are a couple of caveats about reading too much into the sharp divide the authors found. Given that Twitter"s user base is younger and more metropolitan than the societal norm, it"s not surprising that it"s weighted to the left. It"s worth noting that this study was undertaken more than a year ago; since then, Twitter has grown dramatically, while global politics have largely skewed back toward the right. Twitter"s user base today might reflect a more-balanced political picture. Either way, there"s a big split.
Twitter has secondary and tertiary benefits. Most organizations comprehend Twitter in simple terms: More followers means more exposure. But the study shows that it"s not just about those you follow, but those your followers follow—essentially the people in your extended network. The network offers a number of routes for information from fresh sources to get to you. According to the study, some 80 percent of users choose to follow at least 10 media sources, but they are exposed to between 6 and 10 times as many media sources through their friends.
People outweigh brands. Many of the biggest Twitter accounts are big media brands such as CNN (TWX) and Time, but the study suggests that Twitter"s active users tend to prefer individuals over outlets. So while the average follower of @NYTimes (NYT) has six followers apiece, individual journalists have followers who boast a median following count of around 100. That gives individual journalists—who are, the study says, more likely to link to a multiplicity of sources—a much wider, more influential network of connections.
The inference is that the personal touch of a journalist is more important than the lofty, impersonal tone of publications that largely act as promotion channels for their content. It"s a discovery that reminded me of Twitter"s recent blog post on the science of the hashtag, which found that hashtags explode in usage when they are picked up by individuals with the most dedicated—not necessarily the largest—followings.
Active users access a wider range of views. The researchers say that indirect exposure expands political diversity by a "significant amount," despite other studies showing a tendency for social networks to do the opposite. "Other studies have found a stronger tendency of homophily; blogs of different political views rarely linked to each other," they point out. "One possible reason is that a Twitter network encompasses several different relationships—from shared interest, to familial ties, friends, and acquaintances—so political similarity doesn"t necessarily exist in all such ties."
This is not to say that Twitter"s creators should be preparing a Nobel Prize-winning speech. Far from it: The influence of its diversity is unknown. It could be that many people who see messages they disagree with simply change their behavior to screen out such material in future. But it shows that there is a potential to do something positive at Twitter. It"s clear there"s much work to be done. The researchers say they want to investigate a number of areas they"ve uncovered, having provided important insights at a time when politics seem more fractious and divided than ever.
2011.04.12 View 10731
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Artificial Spore Production Technology Developed
The core technology needed in the development of ‘biosensors’ so crucial in diagnosing illnesses or pathogens was developed by Korean research team.
KAIST’s Professor Choi In Seung of the department of Chemistry developed the technology that allows for the production of Artificial Spore by selectively coating a live cell.
In the field of engineering the problem in developing the next generation bio sensor, the cell based sensor, was that it was difficult to keep a cell alive without division for a long time. Once a cell is taken out of the body, it will either divide or die easily.
Professor Choi’s research team mimicked the spore, which has the capability to survive harsh conditions without division, and chemically coated a live cell and artificially created a cell similar to that of a spore.
The physical and biological stabilities of the cell increased by coating an artificial shell over the yeast cell. The shell is composed with a protein similar to that of the protein that gives mussels its stickiness. In addition by controlling the thickness of the shell, the division rate of the yeast can be controlled.
Professor Choi commented that this technology will serve as the basis for the single cell based biosensor.
The research was conducted together with Professor Lee Hae Shin of KAIST department of Chemistry and Professor Jeong Taek Dong of Seoul National University’s department of Chemistry and was published as the cover paper of ‘Journal of the American Chemical Society’.
2011.04.01 View 11851
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A Light Weight, Energy Effcient Household Polysomnography (PSG) System Developed
A smart ‘household polysomnography (PSG) system’ was developed by domestic research team.
Professor Yoo Hui Joon and his research team of KAIST’s department of Electricity and Electronic Engineering successfully developed a PSG system that is light weight and has high performance levels. The conventional PSG systems were complex with numerous lines and wires.
The PSG is used to monitor biological signals during sleep and the monitored results are used to diagnose and cure sleep-related illnesses and disorders. However because of restrictions like the size of the machine, impurities, and the change in environment, multiple trials over several days were required to obtain accurate data.
The system developed by the research team is lighter than a q-tip so as to not disturb the patient’s sleep. It also has Intelligent Circuit (IC) that detects when sensors come detached and automatically replaces the sensor with another sensor thereby allowing continual monitoring of the user.
A low-power consuming circuit was implemented allowing the entire system to run continuously on a single coin battery for 10 hours which effectively decreased the weight of the system and simultaneously allows for uninterrupted monitoring of the user over the entire sleep cycle.
Even a remote diagnosis system can be implemented. The user will don the PSG and sleep at home, ensuring that a normal heat beat rate, brain waves, breathing, etc. will be monitored. The data procured overnight can be sent to the experts online who will be able to diagnose remotely.
The research team plans on performing research in cooperation with the KAIST hospital and U-Healthcare research.
The research result is winning worldwide rave. The system was announced in the International Solid-State Circuits Conference (ISSCC) and was published in ISSCC magazine and in Japan’s NIKKEI Electronics January edition.
2011.03.25 View 10749
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KAIST paves the way to commercialize flexible display screens
Source: IDTechEX, Feb. 28, 2011
KAIST paves the way to commercialize flexible display screens
28 Feb 2011
Transparent plastic and glass cloths, which have a limited thermal expansion needed for the production of flexible display screens and solar power cells, were developed by researchers at KAIST (Korea Advance Institute of Science & Technology).
The research, led by KAIST"s Professor Byoung-Soo Bae, was funded by the Engineering Research Center under the initiative of the Ministry of Education, Science and Technology and the National Research Foundation. The research result was printed as the cover paper of "Advanced Materials".
Professor Bae"s team developed a hybrid material with the same properties as fiber glass. With the material, they created a transparent, plastic film sheet resistant to heat. Transparent plastic film sheets were used by researchers all over the world to develop devices such as flexible displays or solar power cells that can be fit into various living spaces. However, plastic films are heat sensitive and tend to expand as temperature increases, thereby making it difficult to produce displays or solar power cells.
The new transparent, plastic film screen shows that heat expansion index (13ppm/oC) similar to that of glass fiber (9ppm/oC) due to the presence of glass fibers; its heat resistance allows to be used for displays and solar power cells over 250oC.
Professor Bae"s team succeeded in producing a flexible thin plastic film available for use in LCD or AMOLED screens and thin solar power cells.
Professor Bae commented, "Not only the newly developed plastic film has superior qualities, compared to the old models, but also it is cheap to produce, potentially bringing forward the day when flexible displays and solar panels become commonplace. With the cooperation of various industries, research institutes and universities, we will strive to improve the existing design and develop it further."
http://www.printedelectronicsworld.com/articles/kaist_paves_the_way_to_commercialize_flexible_display_screens_00003144.asp?sessionid=1
2011.03.01 View 12314
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Interdisciplinary Research on World Environmental Problems with Humanities
KAIST’s Professor Michael Pak (department of Humanities and Social Sciences) has published a paper in ‘Environmental Science and Technology, ES&T’ and was made Lead Feature.
His was the only paper published with a humanities background and his topic of discussion was ‘Environmentalism Then and Now: From Fears to Opportunities, 1970-2010’ in which he discussed the history of pro-environment activities, the patterns it showed, and its outlook.
Professor Park noted that the problems and concerns over the environment is not a recent phenomenon. It took over 50 years for the environmental problems to resurface after being the ‘hot issue’ of the time during the industrial revolution in the 19th century.
Professor Park deduced that there is a clear historical pattern.
Professor Park insisted that the two areas of Environmental Research ‘Global Warming’ and ‘Change in Weather’. Especially because these two areas are rife with uncertainty as it is, and making policies based on inaccurate information is taking a gamble.
Professor Park majored in history in UC Berkeley, received his masters’ and doctorate at Harvard University and was the professor at Massachusetts College of Art and Design before coming to KAIST at 2008.
2011.02.23 View 10519
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New Bio-Clock gene and its function found
The Ministry of Education, Science and Technology announced that a Korean research team has found a new gene responsible for maintaining the bio-clock (twenty-four) and its mechanism.
Twnety-four was led by Professor Choi Joon Ho and Dr. Lee Jong Bin of KAIST (department of Biology) and was a joint operation with Professor Ravi Allada and Dr.Lim Jeong Hoon of Northwestern University (department of neurobiology) and the result was published in ‘Nature’ magazine.
The research team experimented with transformed small fruit flies for 4 years and found that there was an undiscovered gene that deals with the bio rhythm in the brain which they named ‘twenty-four’.
The understanding with genes prior to twenty-four was that these genes regulate biorhythm in the transcription phase (DNA to mRNA). Twenty-four operates in the step after transcription when the ribosome creates proteins. Especially twenty-four has a great effect on the ‘period protein’ which acts as a sub-atomic clock that regulates the rhythm and life of each cell.
The experiment was innovational in that it was able to scientifically prove the function of the protein produced by the gene.
The result is expected to help solve the problems associated with sleep disorders, jetlags, eating rhythms, bio rhythms, etc.
The name twenty-four was the fact that a day, a cycle, is 24 hours long and the gene’s serial numbers CG4857 adds up to twenty four.
2011.02.23 View 10895
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Professor Min Beom Ki develops metamaterial with high index of refraction
Korean research team was able to theoretically prove that a metamaterial with high index of refraction does exist and produced it experimentally.
Professor Min Beom Ki, Dr. Choi Moo Han, and Doctorate candidate Lee Seung Hoon was joined by Dr. Kang Kwang Yong’s team from ETRI, KAIST’s Professor Less Yong Hee’s team, and Seoul National University’s Professor Park Nam Kyu’s team. The research was funded by the Basic Research Support Program initiated by the Ministry of Education, Science, and Technology and Korea Research Federation.
The result of the research was published in ‘Nature’ magazine and is one of the few researches carried out by teams composed entirely of Koreans.
Metamaterials are materials that have physical properties beyond those materials’ properties that are found in nature. It is formed not with atoms, but with synthetic atoms which have smaller structures than wavelengths.
The optical and electromagnetic waves’ properties of metamaterials can be altered significantly which has caught the attention of scientists worldwide.
Professor Min Beom Ki’s team independently designed and created a dielectric metamaterial with high polarization and low diamagnetism with an index of refraction of 38.6, highest synthesized index value.
It is expected that the result of the experiment will help develop high resolution imaging system and ultra small, hyper sensitive optical devices.
2011.02.23 View 15450
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Success in differentiating Functional Vascular Progenitor Cells (VPC)
KAIST’s Professor Han Yong Man successfully differentiated vascular progenitor cells from human embryonic stem cells and reversed differentiated stem cells.
The research went beyond the current method of synthesis of embryonic body or mice cell ball culture and used the careful alteration of signal transmission system of the human embryonic stem cells to differentiate the formation of vascular progenitor cells.
The team controlled the MEK/ERK and BMP signal transmission system that serves an important role in the self replication of human embryonic stem cells and successfully differentiated 20% of the cells experimented on to vascular progenitor cells.
The vascular progenitor cells produced with such a method successfully differentiated into cells forming the endodermis of the blood vessel, vascular smooth muscle cells and hematopoietic cells in an environment outside of the human body and also successfully differentiated into blood vessels in nude mice.
In addition, the vascular progenitor cell derived from human embryonic cells successfully formed blood vessels or secreted vascular growth factors and increased the blood flow and the necrosis of blood vessels when injected into an animal with limb ischemic illness.
The research was funded by the Ministry of Education, Science and Technology, 21st Century Frontier Research and Development Institution’s Cell Application Research Department and Professor Ko Kyu Young (KAIST), Professor Choi Chul Hee (KAIST), Professor Jeong Hyung Min (Cha Medical School) and Doctor Jo Lee Sook (Researcher in Korea Bio Engineering Institute) participated in it.
The results of the research was published as the cover paper of the September edition of “Blood (IF:10.55)”, the American Blood Journal and has been patented domestically and has finished registration of foreign PCT.
The results of the experiment opened the possibility of providing a patient specific cure using stem cells in the field of blood vessel illness.
2011.01.18 View 12328 -
Explanation for the polymerized nucleic acid enzyme's abnormal activation found
KAIST’s Professor Park Hyun Kyu of the Department of Bio Chemical Engineering revealed on the 23rd of December 2010 that his team had successfully developed the technology that uses the metal ions to control the abnormal activation of nucleic acids’ enzymes and using this, created a logic gate, which is a core technology in the field of future bio electrons.
The polymerized nucleic acid enzyme works to increase the synthesis of DNA and kicks into action only when the target DNA and primers form complimentary pairs (A and T, C and G).
Professor Park broke the common conception and found that it is possible for none complimentary pairs like T-T and C-C to initiate the activation of the enzyme and thus increase the nucleic acid production, given that there are certain metal ions present.
What Professor Park realized is that the enzymes mistake the uncomplimentary T-T and C-C pairs (with stabilized structures due to the bonding with mercury and silver ions) as being complimentary base pairs. Professor Park described this phenomenon as the “illusionary polymerase activity.”
The research team developed a logic gate based on the “illusionary polymerase activity’ phenomenon.” The logic gate paves the way to the development of future bio electron needed for bio computers and high performance memories.
Professor Park commented, “The research is an advancement of the previous research carried on about metal ions and nucleic acid synthesis. Our research is the first attempt at merging the concepts of the two previously separately carried out researches and can be adapted for testing presence of metal ions and development of a new single nucleotide polymorphic gene analysis technology.”
Professor Park added that, “Our research is a great stride in the field of nano scale electron element research as the results made possible the formation of accurate logic gates through relatively cost efficient and simple system designs.”
On a side note, the research was funded by Korea Research Foundation (Chairman: Park Chan Mo) and was selected as the cover paper for the December issue of ‘Angewandte Chemie International Edition’.
2011.01.18 View 9935 -
Rise of the mimic-bots that act like we do: Human-machine teamwork.
An online magazine, Technology Marketing Corporation, based in the UK published an article, dated January 8, 2011, on a robot research project led by Professor Jong-Hwan Kim from the Electrical Engineering Department. The article follows below:
Technology Marketing Corporation
[January 08, 2011]
Rise of the mimic-bots that act like we do Human-machine teamwork
(New Scientist Via Acquire Media NewsEdge) Rise of the mimic-bots that act like we doA robot inspired by human mirror neurons can interpret human gestures to learn how it should actNow follow meA robot inspired by human mirror neurons can interpret human gestures to learn how it should actA HUMAN and a robot face each other across the room. The human picks up a ball, tosses it towards the robot, and then pushes a toy car in the same direction.
Confused by two objects coming towards it at the same time, the robot flashes a question mark on a screen. Without speaking, the human makes a throwing gesture. The robot turns its attention to the ball and decides to throw it back.
In this case the robot"s actions were represented by software commands, but it will be only a small step to adapt the system to enable a real robot to infer a human"s wishes from their gestures.
Developed by Ji-Hyeong Han and Jong-Hwan Kim at the Korea Advanced Institute of Science and Technology (KAIST) in Daejeon, the system is designed to respond to the actions of the person confronting it in the same way that our own brains do. The human brain contains specialised cells, called mirror neurons, that appear to fire in the same way when we watch an action being performed by others as they do when we perform the action ourselves. It is thought that this helps us to recognise or predict their intentions.
To perform the same feat, the robot observes what the person is doing, breaks the action down into a simple verbal description, and stores it in its memory. It compares the action it observes with a database of its own actions, and generates a simulation based on the closest match.
The robot also builds up a set of intentions or goals associated with an action. For example, a throwing gesture indicates that the human wants the robot to throw something back. The robot then connects the action "throw" with the object "ball" and adds this to its store of knowledge.
When the memory bank contains two possible intentions that fit the available information, the robot considers them both and determines which results in the most positive feedback from the human?- a smile or a nod, for example. If the robot is confused by conflicting information, it can request another gesture from the human. It also remembers details of each interaction, allowing it to respond more quickly when it finds itself in a situation it has encountered before.
The system should allow robots to interact more effectively with humans, using the same visual cues we use. "Of course, robots can recognise human intentions by understanding speech, but humans would have to make constant, explicit commands to the robot," says Han. "That would be pretty uncomfortable."Socially intelligent robots that can communicate with us through gesture and expression will need to develop a mental model of the person they are dealing with in order to understand their needs, says Chris Melhuish, director of the Bristol Robotics Laboratory in the UK. Using mirror neurons and humans" unique mimicking ability as an inspiration for building such robots could be quite interesting, he says.
Han now plans to test the system on a robot equipped with visual and other sensors to detect people"s gestures. He presented his work at the Robio conference in Tianjin, China, in December. nAs the population of many countries ages, elderly people may share more of their workload with robotic helpers or colleagues. In an effort to make such interactions as easy as possible, Chris Melhuish and colleagues at the Bristol Robotics Laboratory in the UK are leading a Europe-wide collaboration called Cooperative Human Robotic Interaction Systems that is equipping robots with software that recognises an object they are picking up before they hand it to a person. They also have eye-tracking technology that they use to monitor what humans are paying attention to. The goal is to develop robots that can learn to safely perform shared tasks with people, such as stirring a cake mixture as a human adds milk.
(c) 2011 Reed Business Information - UK. All Rights Reserved.
2011.01.10 View 9681