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Eggshell-like Cell Encapsulation and Degradation Technology Developed
Some bacteria form endospores on cell walls to protect their DNA in case of nutrient deficiency. When an endospore meets a suitable environment for survival, the cell can revert to the original state from which it can reproduce.
The technique that can artificially control such phenomenon was developed by an international team of researchers. At first, a cell is wrapped and preserved like an egg. When the cell is needed, the technique allows the endospore to decompose while it is alive. Future applications for this technique include cell-based biosensor, cell therapy, and biocatalyst processes.
Professors Insung Choi and Younghoon Lee from the Department of Chemistry at KAIST as well as and Professor Frank Caruso from the University of Melbourne developed this technique which permits a cell to stay alive by coating it with film on a nanometer scale and then to be decomposed while it is alive.
The research finding was published in the November 10th issue of Angewandte Chemie International Edition as the lead article.
Cell encapsulation allows researchers to capture a cell in a tight capsule while it is alive. It is highly recognized in cell-based applications where the control of cell stability and cell-division is the biggest issue.
Traditional cell encapsulation methods utilized organic film or inorganic capsules that are made of organic film moldings. Although these films tightly closed around the cell, because they were not easily decomposable, it was difficult to apply the method.
The research team succeeded in encapsulating each cell in a metal-polyphenol film by mixing tannic acid and iron ion solution with yeast cells.
Usually extracted from oak barks or grape peels, tannic acid is a natural substance. It forms a metal-polyphenol film within ten seconds when it meets iron ions due to its high affinity with cells. Cells encapsulated with this film presented high survival rates. Since the film forms quickly in a simple manner, it was possible to obtain large amount of encapsulated cells.
The research team also found that the metal-polyphenol film was stable in neutral pH, but is easily degradable under a weak acidic condition. Using this property, they were able to control cell division by restoring the cell to its pre-encapsulated state at a desired moment.
Protecting the cell from the external environment like an egg shell, the metal-polyphenol film protected the cell against foreign conditions such as lytic enzymes, extended exposure to UV radiation, and silver nanoparticles. The research indicated that the encapsulated cells had a high survival rate even under extreme environments.
Professor Lee said that “not only the cells remain alive during the encapsulation stage, but also they can be protected under extreme environment.” He added, “This is an advanced cell encapsulation technology that allows controlling cell-division of those cells through responsive shell degradation on-demand.”
Professor Choi commented, “Although the cell encapsulation technology is still in its infancy, as the technology matures the application of cell-manipulation technology will be actualized.” He highlighted that “it will serve as a breakthrough to problems faced by cell-based applications.”
Sponsored by the Ministry of Science, ICT and Future Planning and the National Research Foundation of Korea, the research was led by two Master’s candidates, Ji Hun Park and Kyung Hwan Kim, under the joint guidance of research professors from KAIST and the University of Melbourne.
Figure 1: Lead article of Angewandte Chemie
Background: Shows a live native yeast (in green) encapsulated in a metal-polyphenol film (in red) illustrating the vitality of the yeast
Front: A native yeast at each encapsulation stage
Pictured on the bottom left is a cell prior to encapsulation. Following the red arrow, the native yeast is in purple to show metal-polyphenol film formed around the cell. The cell after the green arrow is a visualization of the degradation of the film in weak acidic condition.
Figure 2: A mimetic diagram of cell encapsulation with a metal-polyphenol film
Top: A native yeast before encapsulation
Middle: A native yeast encapsulated with Tannic Acid-Fe (III) Nanoshell – cell-division of the encapsulated cell is controlled by pH and the shell is protected against silver nanoparticle, lytic enzyme, and UV-C
Bottom: Shell degradation on-demand depending on pH
2014.11.18 View 10663 -
The Website of the KAIST Industrial Design Department Receives a Design Award
The 10th QS-Apple Higher Education Conference and Exhibition took place on November 11-13, 2014 in Taipei, Taiwan. The conference was hosted by Quacquarelli Symonds, a British company specializing in education, which publishes annually its world university rankings. Apple stands for Asia Pacific Professional Leaders in Education.
The QS-Apple conference supports the internationalization of Asia Pacific universities by providing opportunities for networking, exchanging best practices, and discussing recent developments in higher education. During the conference, the organizers presented the Creative Awards for best international education promotional designs in four categories: Website Pages, Video, Print Advertisement, and International Student Recruitment Brochures.
KAIST’s Industrial Design Department received the Best Website Pages Award for their website in recognition of high levels of user convenience and satisfaction as well as English language services. A total of 39 universities in the Asia and Pacific region competed in this category, and Nanyang Technological University in Singapore came in second place, followed by Hong Kong Baptist University in third.
2014.11.13 View 9251 -
Distinguished Professor Sang Yup Lee Accepts an Honorary Professorship at Beijing University of Chemical Technology
Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering at KAIST has been appointed an honorary professor at Beijing University of Chemical Technology (BUCT). Founded in 1958, BUCT is one of the outstanding universities in mainland China, especially in chemistry studies.
In addition to the Chinese Academy of Sciences (2012), Shanghai Jiao Tong University (2013), Wuhan University (2014), and Hebei University of Technology (2014), this is the fifth honorary professorship Professor Lee has received from higher education institutions in China.
Professor Lee was recognized for his pioneering research in systems metabolic engineering of microorganisms necessary for the development of green chemical industries. He succeeded in producing succinic acid through bacterial fermentation and engineering plastic raw materials in the most effective and economical method for the first time in the world. Professor Lee also developed polylactic acid, a bio-based polymer that allows plastics to be produced through natural and renewable resources, as well as the microbial production of alkanes, an alternative to gasoline that can be produced from fatty acids.
Professor Lee has been actively working as a member of a group of global leaders supported by the World Economic Forum (WEF), serving as the Chairman of the Future of Chemicals, Advanced Materials & Biotechnology, Global Agenda Councils, WEF.
2014.11.13 View 12004 -
A KAIST Student Team Wins the ACM UIST 2014 Student Innovation Contest
A KAIST team consisted of students from the Departments of Industrial Design and Computer Science participated in the ACM UIST 2014 Student Innovation Contest and received 1st Prize in the category of People’s Choice.
The Association for Computing Machinery (ACM) Symposium on User Interface Software and Technology (UIST) is an international forum to promote innovations in human-computer interfaces, which takes place annually and is sponsored by ACM Special Interest Groups on Computer-Human Interaction (SIGCHI) and Computer Graphics (SIGGRAPH). The ACM UIST conference brings together professionals in the fields of graphical and web-user interfaces, tangible and ubiquitous computing, virtual and augmented reality, multimedia, and input and output devices.
The Student Innovation Contest has been held during the UIST conference since 2009 to innovate new interactions on state-of-the-art hardware. The participating students were given with the hardware platform to build on—this year, it was Kinoma Create, a JavaScript-powered construction kit that allows makers, professional product designers, and web developers to create personal projects, consumer electronics, and "Internet of Things" prototypes. Contestants demonstrated their creations on household interfaces, and two winners in each of three categories -- Most Creative, Most Useful, and the People’s Choice -- were awarded.
Utilizing Kinoma Create, which came with a built-in touchscreen, WiFi, Bluetooth, a front-facing sensor connector, and a 50-pin rear sensor dock, the KAIST team developed a “smart mop,” transforming the irksome task of cleaning into a fun game. The smart mop identifies target dirt and shows its location on the display built in the rod of a mop. If the user turns on a game mode, then winning scores are gained wherever the target dirt is cleaned.
The People’s Choice award was decided by conference attendees, and they voted the smart mop as their most favorite project.
Professor Tek-Jin Nam of the Department of Industrial Design at KAIST, who advised the students, said, "A total of 24 teams from such prestigious universities as Carnegie Mellon University, Georgia Institute of Technology, and the University of Tokyo joined the contest, and we are pleased with the good results. Many people, in fact, praised the integration of creativity and technical excellence our have shown through the smart mop.”
Team KAIST: pictured from right to left, Sun-Jun Kim, Se-Jin Kim, and Han-Jong Kim
The Smart Mop can clean the floor and offer users a fun game.
2014.11.12 View 11666 -
President Steve Kang will serve as the Chairman of Global Agenda Council on the Future of Electronics of the World Economic Forum
President Steve Kang of KAIST has been appointed to the Chairman of the Global Agenda Council (GAC) on the Future of Electronics of the World Economic Forum (WEF). He will serve the position for two years until September 2016.
President Kang and WEF council members co-hosted, with the government of the United Arab Emirates (UAE), the Future Circles Initiative, a future-focused, innovative brainstorming conference to help find strategies and ideas for the development of UAE. The conference took place on November 11-12, 2014 at the Mina Al Salam Hotel in Dubai.
WEF has about 80 GACs. Each council consists of 15 experts and thought leaders from the academia, industry, government, business, and non-profit sector and deals with specific issues that are important and relevant to the global community such as ageing, artificial intelligence and robotics, brain research, food and nutrition security, education, social media, and future of chemicals, advanced materials and biotechnology.
President Kang was recognized for his contribution to the advancement of science and higher education as an engineer, scholar, and professor. He led the development of the world’s premier CMOS 32-bit microprocessors while working at the AT&T Bell Laboratories. He also taught and conducted research at the University of California, Santa Cruz, and the University of Illinois, Urbana-Champaign. President Kang served as the chancellor of the University of California at Merced from March 2007 to June 2011.
2014.11.11 View 9497 -
Professor Joong-Keun Park Receives SeAH Heam Academic Award
Professor Joong-Keun Park of the Department of Materials Science and Engineering at KAIST received an award from SeAH Steel Corp. in recognition of his academic achievements in the field of metallic and materials engineering.
The award was presented at the 2014 Fall Conference of the Korean Institute of Metals and Materials which took place on October 22-24 at the Kangwon Land Convention Hotel.
The award, called “SeAH Heam Academic Award,” is given annually to a scholar who has contributed to the development of new metal and polymer composite materials and its related field in Korea. Following the award ceremony, Professor Park gave a keynote speech on ferrous metals for automotive materials.
2014.11.04 View 8353 -
The KAIST Institute for Disaster Studies (KIDS) Opens
About 60 professors from across different departments at KAIST teamed up to make Korean society safer and more secure.
The professors voluntarily created the KAIST Institute for Disaster Studies (KIDS) that will implement the following responsibilities:
- Conduct research on disaster prevention and reduction
- Develop policy on safety and preventive measures for the public
- Establish resilience engineering programs at the university
- Create a platform for social media and machine-based information management
- Develop robot-based search and rescue mission programs
- Conduct disaster risk assessments and develop disaster-recovery plans
- Establish virtual reality programs for training and education
An opening ceremony for the institute took place on campus on October 22, 2014. President Steve Kang of KAIST, Young Jin, a National Assemblyman of the Republic of Korea, Myung-Ja Kim, a former Minister of the Environment of the Republic of Korea, Professor Hee-Kyung Park of the Department of Civil and Environmental Engineering at KAIST, and other dignitaries attended the ceremony.
Professor Park, the Director of KIDS, said, “In recent years, our society has seen many tragic accidents that claimed hundreds of lives. This prompted us to examine the fundamental cause of accidents and forced us to review our current public safety policies and measures. As a result, we were able to identify many reasons, among others, technological problems in public facilities and structures, lack of social policies and systems to protect public safety, and human error.”
He further explained the need for KIDS as follows:
“In order to understand the cause of disasters and prepare remedies, such as how disasters happen, how to respond to them, and what to do for recovery, we need to have a comprehensive approach to the issues from the various perspective of social policy, science, and engineering. KIDS has been created to meet these needs.”
Following the opening ceremony, a seminar was held on the topic of “KIDS’s Mission and Its Role.”
2014.10.24 View 7673 -
Parents of Alumni Donates to KAIST
Parents of KAIST alumni donated a scholarship of USD 4,800 to the university. A donation ceremony took place at the president’s office on October 21, 2014.
Two sons and the daughter-in-law of Ki-Hong Oh (husband) and Soon-Yi Kim (wife) studied at KAIST. Hwan-Hee Oh and Hwan-Yup Oh graduated with Master’s degrees in Mechanical Engineering in 2005 and 2009, respectively. Jung-Im Min received a Ph.D. in Mechanical Engineering in 2005.
Oh and Kim, who are orange growers in Jeju Island, Korea, said, “We have always appreciated the generous support our children received from KAIST and thought for many years about ways to make a contribution to the development of the university. Although this is a small amount, we are pleased to express our appreciation to KAIST.”
The couple hope that their donation will inspire others in Korea to follow suit and added, “Just like many of the great universities in the west which are supported through donations made by their alumni and people from all walks of life, we would like to see Korean universities also benefit from such a culture and practice.”
President Steve Kang expressed his gratitude to the couple and said, “KAIST will cherish your philanthropic good deeds, and the scholarship will be used to support students as you wish.”
2014.10.22 View 8897 -
KAIST and Samsung Heavy Industries Celebrate 20 Years of Cooperation
KAIST and Samsung Heavy Industries (SHI) celebrated the twentieth anniversary of their university-industry cooperation in shipbuilding and ocean technology research. Established in 1995, the cooperation has remained steadfast for two decades, even times when Korea suffered gravely from its financial crisis in late 1990s.
A ceremony to commemorate the cooperation took place at the Mechanical Engineering Building on October 17, 2014. About thirty distinguished guests including the Head of the Department of Mechanical Engineering, Professor Choong-Sik Bae, and the chief engineer of SHI Marine Research Institute, Dr. Jong-Soo Seo, participated in the ceremony.
The cooperation programs included appointing advisory professors for technological support, implementing business-based academic courses, offering university-industry wide open lectures, opening regular courses for auditing, and finding possible joint researches. Through this cooperation, Samsung has secured technologies needed for industry, and KAIST has produced students who have real-world experience in industrial fields.
Twenty years of cooperation has produced shining results by running various programs such as technological advice, special lectures, small-scale research projects, consignment research projects, and courses for research and design personnel.
For example, what started as a small-scale research project with USD 4,800 in funding, the LNG (Liquefied Natural Gas) related research has grown into a large-scale research project with a total of USD 2.85 million in funding. As a result, they developed a secondary barrier for LNG carriers which was recognized by Lloyd‘s Register. Their research eventually lowered ship manufacturing costs tremendously.
In 2003, the cooperation project received the presidential citation from the University-Industry Cooperation Competition organized by the Federation of Korean Industries.
KAIST and SHI planned to increase their cooperation to make it Korea’s leading university-industry cooperation program.
Professor Bae said, “Our programs to focus on solving industrial problems have turned out quite successful.” He emphasized that “for this reason, the cooperation even continued during the Asian financial crisis in 1997.”
He added, “By expanding the current cooperation, we aim to make it an exemplary program that contributes to Korea’s shipbuilding and ocean plant industries.”
2014.10.21 View 10150 -
Wuhan University, China, Appoints Distinguished Professor Sang Yup Lee as Honorary Professor
Sang Yup Lee, Distinguished Professor of the Department of Chemical and Biomolecular Engineering at KAIST, has been appointed an honorary professor at Wuhan University in Hubei Province, China. This is the third time that Professor Lee has received an honorary professorship from Chinese academic institutions. The Chinese Academy of Sciences appointed him an honorary professor in 2012, and Shanghai Jia Tong University asked him to serve as an advisory professor in 2013, respectively.
Professor Lee was recognized for his pioneering research in systems metabolic engineering of microorganisms necessary for the development of green chemical industries. He succeeded in producing succinic acid through bacterial fermentation and engineering plastic raw materials in the most effective and economical method for the first time in the world. Professor Lee also developed polylactic acid, a bio-based polymer that allows plastics to be produced through natural and renewable resources, as well as the microbial production of alkanes, an alternative to gasoline that can be produced from fatty acids.
Professor Lee has been actively working as a member of a group of global leaders supported by the World Economic Forum (WEF), serving the Chairman of the Future of Chemicals, Advanced Materials & Biotechnology, Global Agenda Councils, WEF.
Wuhan University is a comprehensive and key national university selected by the Chinese government as a major recipient of state funding for research. It is also known as one of the most beautiful campuses in China.
2014.10.20 View 9770 -
KAIST and University of California, Santa Cruz, Agree to Cooperate
KAIST and the University of California in Santa Cruz signed a memorandum of understanding (MOU) at the KAIST campus on October 14, 2014.
The two institutions agreed to cooperate in the following four areas:
- Research collaboration in genomics and biology
- Academic exchanges in engineering and information communication technology
- Student and faculty exchange programs
- Joint academic workshops and seminars
Following the MOU signing ceremony, Dr. George Blumenthal, the Chancellor of UC Santa Cruz, held a special seminar for KAIST students and faculty, during which he shared some of the success stories made through UC Santa Cruz’s close cooperation with companies in Silicon Valley.
President Steve Kang of KAIST praised the MOU saying, “KAIST and UC Santa Cruz have top-notch research professionals, and the MOU will reinforce their research capability. We hope that the two universities will carry out many research projects that bring significant impact on the world.”
UC Santa Cruz was established in 1965 as a public research university committed to undergraduate education. The university has a total student population of 16,000 (15,375 undergraduates and 1,378 graduates). Offering 60 undergraduate majors, UC Santa Cruz's faculty includes six recipients of Pulitzer Prizes and five MacArthur Genius Awards. The university was ranked the 2nd in the world for research influence in 2012-2013 Times Higher Education rankings.
2014.10.15 View 8666 -
KAIST and University of Waterloo in Canada Agree to Enhance Cooperation
KAIST and the University of Waterloo, Canada, signed a memorandum of understanding (MOU) to explore collaboration in education and research in areas such as computer science, electrical engineering, chemical engineering, quantum computing, and nanotechnology. The two universities also agreed to expand their cooperation in entrepreneurship, technology transfer, and startup support programs. The signing ceremony took place at the University of Waterloo (UW) in Ontario, Canada, on September 22, 2014.
Feridun Hamdullahpur, president and vice-chancellor of UW, noted that “KAIST and the University of Waterloo have so much in common. Both institutions pursue excellence in teaching and research, attract some of the highest quality students and faculty alike, and seek out innovation that has the potential to change the world.”
President Steve Kang said, “The University of Waterloo has been leading the co-operative education field, offering valuable opportunities to young students to receive classroom-based education with practical work experience. This has been an important approach in higher education, and perhaps more so in this age when technological innovations create new values for social advancement and new opportunities for better growth. I hope that through the collaboration, KAIST and the University of Waterloo will produce research outcomes with global recognition.”
The University of Waterloo, located at the heart of Canada’s technology hub, has become one of the nation’s leading comprehensive universities in just half a century. The university is home to the world’s largest post-secondary co-operative education program, encouraging enterprising partnerships in learning and research.
The picture shows the signing of the MOU by President Steve Kang (right) and President and Vice-chancellor Feridun Hamdullahpur (left).
2014.09.26 View 8345