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Academic Award Established in the Honor of Professor Jae-gyu Lee
An academic award has been established to celebrate the academic achievements of Jae-gyu Lee, a chair professor at KAIST’s Business and Management Department.
The Korean Society of Management Information Systems (KMIS) created the “Safe Internet Jae-gyu Lee Academic Award” at the 2015 KMIS Fall Symposium held on November 21, 2015 at the Business and Management building of Yonsei University in Seoul.
The award will be presented to researchers operating both in and outside Korea, who strive to achieve a clean and safe Internet environment by preventing cyber terrors, attacks, and crimes.
Appointed as the President of the Association for Information Systems (AIS), a global academic organization to advance the field of information systems, in July 2015, Professor Lee has adopted the “safe and clean Internet culture” as the official vision of the AIS. During his inaugural speech, he urged the international community including AIS to work together for better solutions to cyber problems.
For the implementation of the Safe Internet Jae-gyu Lee Academic Award, KMIS plans to form a committee to select winners through evaluations and recommendations. The award will be presented from 2016 forward.
Also, Professor Lee has recently donated USD 87,000 to KMIS to fund research in safe Internet culture and cyberspace security.
2015.11.25 View 6945 -
Open KAIST 2015
KAIST’s research environment and its most recent achievements were open to the public.
KAIST hosted “Open KAIST 2015” over two days from November 5-6, 2015 in which its 17 departments and three research centers were open to the public. The event is one of the largest events that KAIST holds, which permits such public viewings of its facilities. It is the eighth time it has taken place.
During this event, the departments and centers offered 64 programs including laboratory tours, research achievement exhibitions, department introductions, and special lectures.
The “Motion Capture System”of Professor Jun-Yong Noh’s lab (Graduate School of Culture Technology) drew particular attention.
The “Motion Capture System” expresses human and animal motion in three-dimensional (3D) space using infrared cameras and optic markers, which can then be applied to various industries such as movies, games, and animation. During the program, researchers themselves demonstrated the recording of the movement and its conversion into 3D characters.
Professor Yong-Hoon Cho’s laboratory introduced the scientific mechanism behind the Light Emitting Diode (LED) as well as its manufacturing process under the topic:“A to Z of LED Production.” The reserachers explained that how green LED is much more efficient compared to previous light sources and presented applications that how it is widely used in everyday life in smart phones, electronic displays, and other mobile gadgets.
Professor Jun-tani of the Department of Electronic and Electrical Engineering introduced “Humanoid Robot Nao’s Imitation of Human Motions.” Nao is an autonomous, programmable humanoid robot developed by a French robotics company based in Paris. Nao has an artificial neural circuit, which is the functional equivalent of a human brain, and can thus mimic the subject’s motions through learning.
In addition, Professor Hyo-Choong Bang (Department of Aerospace Engineering) in his lecture on “Unmanned Vehicle Research and Nano Satellites” and Professor Hyun Myung (Department of Civil and Environmental Engineering) on his lecture on “Future Civilization Robot System: the Jellyfish Elimination Robotic Swarm and the Wall-Climbing Drone” provided information on the progress of their respective research.
KAIST also displayed its most recent research achievements. A lecture on “Information Technology Convergence” offered a showroom for “Dr. M,” which is a mobile healthcare platform. Dr. M is a mobile healthcare system that collects and analyzes biosignals via a smart sensor attached to the human body that shows around 20 advanced technologies.
The Satellite Technology Research Center introduced the public to its “Get to Know Satellites” program on Korea’s first satellite “Our Star 1” in addition to showing the satellite assembly room and the satellite communication center.
Special lectures were also held for visitors. Professor Min-Hyuk Kim and Hye-Yeon Oh of the School of Computing talked about “Computer Graphics and Advanced Video Technology” and “Man and the Computer,” respectively, from the perspective of non-experts.
Another interesting feature was the “Wearable Computer Competition” in which college students held fashion shows with computers attached to their clothes.
Professor Jung Kwon Lee, the Dean of the College of Engineering, who led this event, said that “the Open KAIST, which is being held for the eighth time this year, is an excellent opportunity for the general public to experience KAIST’s research environment.” He hoped this could motivate young adults to widen their spectrum of scientific knowledge and raise affection for science.
2015.11.13 View 9368 -
Using Light to Treat Alzheimer's Disease
Medical application of photoactive chemicals offers a promising therapeutic strategy for neurodegenerative diseases.
A research team jointly led by Professor Chan Beum Park of the Materials Science and Engineering Department at KAIST and Dr. Kwon Yu from the Bionano Center at the Korea Research Institute of Bioscience and Biotechnology (KRIBB) conducted research to suppress an abnormal assembly of beta-amyloids, a protein commonly found in the brain, by using photo-excited porphyrins.
Beta-amyloid plaques are known to cause Alzheimer's disease. This research finding suggests new ways to treat neurodegenerative illnesses including Alzheimer's disease. It was published online as the lead article in the September 21th issue of Angewandte Chemie. The title of the article is “Photo-excited Porphyrins as a Strong Suppressor of ß-Amyloid Aggregation and Synaptic Toxicity.”
Light-induced treatments using organic photosensitizers have advantages to managing the treatment in time and area. In the case of cancer treatments, doctors use photodynamic therapies where a patient is injected with an organic photosensitizer, and a light is shed on the patient’s lesion. However, such therapies had never been employed to treat neurodegenerative diseases.
Alzheimer's starts when a protein called beta-amyloid is created and deposited in a patient’s brain. The abnormally folded protein created this way harms the brain cells by inducing the degradation of brain functions, for example, dementia. If beta-amyloid creation can be suppressed at an early stage, the formation of amyloid deposits will stop. This could prevent Alzheimer’s disease or halt its progress.
The research team effectively prevented the buildup of beta-amyloids by using blue LED lights and a porphyrin inducer, which is a biocompatible organic compound. By absorbing light energy, a photosensitizer such as porphyrin reaches the excitation state. Active oxygen is created as the porphyrin returns to its ground state. The active oxygen oxidizes a beta-amyloid monomer, and by combining with it, disturbs its assembly.
The technique was tested on drosophilae or fruit flies, which were produced to model Alzheimer on invertebrates. The research showed that symptoms of Alzheimer's disease in the fruit flies such as damage on synapse and muscle, neuronal apoptosis, degradation in motility, and decreased longevity were alleviated. Treatments with light provide additional benefits: less medication is needed than other drug treatments, and there are fewer side effects. When developed, photodynamic therapy will be used widely for this reason.
Professor Park said, “This work has significance as it was the first case to use light and photosensitizers to stop deposits of beta-amyloids. We plan to carry the research further by testing compatibility with other organic and inorganic photosensitizers and by changing the subject of photodynamic therapy to vertebrate such as mice.”
Picture 1 – Deposits of Beta-Amyloid in Fruit Flies Stopped by Using Porphyrin and Blue LED Lights
Picture 2 – The Research Finding Published as the Lead Article in Angewandte Chemie (September 2015)
2015.11.11 View 10557 -
Public Lectures by KAIST's Humanities and Social Sciences Research Center
The Humanities and Social Sciences Research Center at KAIST offers public lectures at the International Seminar Hall of the Humanities and Social Sciences building on campus from November 12, 2015 to December 10, 2015. There will be four lectures, all of which will be available in Korean only.
The theme of the lectures is “social issues and strategic solutions.” Experts in various fields including women’s studies, criminal psychology, Go (a Chinese board game) and its philosophy, and Korean studies will participate, offering multifaceted analysis and solutions for social issues in Korea.
Joo-Hee Kim, a researcher at the Korean Women’s Institute of Ewha Women’s University, will lecture on “Problems of Loan Products Exclusively for Women” and discuss the background of "micro-loans" which are often targeted at women, while evaluating the logic of financial corporations behind marketing such products.
Lectures by Professor Ji-Sun Park from the Department of Social Psychology at Ewha Women’s University on “Understanding of Criminal Psychology from Letters,” Professor Soo-Hyun Jeong from the Department of Go at Myeongji University on “Life Lessons and Strategies from Playing Go,” and Professor Seung-Taek Ahn from Kyujanggak Institute for Korean Studies of Seoul National University on “Community Problems in Folk Culture” will follow.
The organizer of the lectures, Professor Jung-Hoon Kim of the Department of Humanities and Social Sciences at KAIST said,
“These lectures will provide local citizens and the KAIST family a wonderful opportunity to understand important social issues from the perspective of social science. It will also serve as a valuable time to think about how our social conflicts could differ from those of other countries, helping us to find solutions.”
To register for these free lectures, go to http://hss.kaist.ac.kr by November 9, 2015.
2015.11.06 View 6225 -
KAIST and University of Illinois at Urbana-Champaign Sign a MOU
KAIST and the University of Illinois at Urbana-Champaign (UIUC) signed a memorandum of understanding on collaboration of research and education on November 5, 2015, at the UIUC campus.
The agreement was made at the request of UIUC, under which the two institutions will exchange students and faculty and implement joint research projects.
President Steve Kang of KAIST said, “With this partnership, KAIST and the University of Illinois at Urbana-Champaign will move forward to advance the fields of medical engineering, life sciences, electrical engineering, and computer science.”
In the picture below, President Steve Kang (second from the right) and Associate Vice President of International Office, Sung-Hyon Myaeng (far right), hold the MOU with UIUC representatives.
2015.11.05 View 4818 -
KAIST Hosts the Wearable Computer Contest 2015
“What you see is a compact electronic system on a dust mask, which monitors the amount of dust taken in by a worker and lets other workers know if the person is injured in an industrial site,” said Bum Taek Jung, a Master’s candidate from Sungkyunkwan University during the Wearable Computer Contest 2015 held in KI building of KAIST on November 5, 2015.
He explained his interest in developing this system, “Dust-related respiratory diseases and falling accidents are still prevalent in industrial sites.” He added, “Using the smart dust mask helps monitoring workers’ physical condition in real time, allowing us to cope with accidents in a much more timely manner.” A smart dust mask is a portable device that alerts the user with orange or red light signs when the amount of dust inhaled by the user is higher than the threshold. Its application on a smartphone can also allow project managers to alert the risk of falling accidents to workers by employing a gyroscope and an accelerometer on the mask.
The Wearable Computer Contest 2015 met for the eleventh time at KAIST on November 5-6, 2015. A wearable computer refers to a portable device which users can wear directly on the body or on their clothes while moving. Products that can provide various services by connecting to a smartphone have become increasingly popular. The contest is an excellent opportunity for university students to design creative wearable systems similar to those often depicted in movies and comics.
This year 102 teams from universities all over the nation participated. After screening and evaluation of their presentations, only 8 teams in the product section and 3 teams in the ideas section were selected for the finals. Of the many entries to the contest, the ECG security system caught many people’s attention. The wearable, which attaches to a shirt, acts like an electrocardiogram. By comparing the ECG reading with the one stored in the data server, the wearable can authenticate the user. The system could be widely used by enterprises and financial companies where tight security and authentication are crucial.
The winners of the product and the ideas sections received USD 4,300 and usd 860 respectively along with Minister Prizes from the Minister of Science, ICT and Future Planning of Korea. The Chairman of the contest, Professor Hoi-Jun Yoo from the Electrical Engineering Department of KAIST said, “The contest will be a great opportunity for anyone to have a look at advanced wearable devices developed through close integration of state-of-the-art technologies and creative ideas from young minds.”
2015.11.05 View 7119 -
KAIST and Hanwha Chemical Agree on Research Collaboration
KAIST signed a memorandum of understanding (MOU) with Hanwha Chemical Co., Ltd., a Korean chemical and auto manufacturer, on November 2, 2015 to establish a research center on campus.
The research center, which will be named “KAIST-Hanwha Chemical Future Technology Research Center,” will implement joint research projects for five years beginning from 2016 to develop innovative, green technologies that will help the Korean chemical industry boost its global competitiveness and to nurture top researchers and engineers in chemical engineering.
The research center will lead the development of next-generation petrochemical materials and manufacturing technology and the establishment of pure high-refining processes which are more energy-efficient and environmentally friendly. KAIST and Hanwha will strive to secure new technologies that have the greatest commercialization potential in the global market. They will also establish a scholarship fund for 15 KAIST doctoral students in the Department of Chemical and Biomolecular Engineering.
Many professors from the Chemical and Biomolecular Engineering Department including Distinguished Professor Sang Yup Lee, who was listed in the Top 20 Translational Researchers of 2014 by Nature Biotechnology this year, and Professor Hyunjoo Lee who received the Woman Scholar award at the 2015 World Chemistry Conference, will work at the research center.
Professor Lee, the head of the research center, said, “Collaborating with Hanwha will give us a strong basis for our efforts to carry out original research and train the best researchers in the field.”
Chang-Bum Kim, the Chief Executive Officer (CEO) of Hanwha Chemical, said,
“We hope our collaborations with KAIST will go beyond the typical industry and university cooperation. The two organizations will indeed jointly operate the research center, and this will become a new model for industry and university cooperation. We expect that the research center will play a crucial role in the development of new products and technologies to grow the Korean chemical industry.”
In the photo, President Steve Kang of KAIST (fourth from left) and CEO Chang-Bum Kim of Hanwha Chemical (fifth from left) hold the MOU together.
2015.11.01 View 9830 -
KAIST Invites Entrepreneurs and Experts to Participate in a Social Technology Innovation Symposium
The Research Institute for Social Technology and Innovation (RISTI) at KAIST hosted the Social Technology Innovation Symposium on November 4, 2015 in KI building, to which 100 social business entrepreneurs and experts in the field were invited.
Social businesses refer to activities of companies, which strive to resolve social problems such as environmental issues, income inequality, and aging societies while seeking profit at the same time. This is different from companies taking social responsibility and non-profit organization serving the community in that they attempt to solve social problems through a sustainable business model.
Held under the theme of “technology capabilities of companies and social business strategies,” this symposium was the first to gather representatives from social venture companies, medium-sized enterprises, and major companies at one place to share their experiences in a social business and to discuss future tasks.
The symposium was divided into sessions with three different topics ranging from social business strategies using information technology, a social business and its business model, and social business strategies of major companies.
The symposium started with keynote speeches delivered by Professor HongKyu Lee, RISTI, and Professor Hong-Tak Lim, RISTI, who discussed the role of technology in a social business. It was followed by plenary sessions led by CEOs who are running social businesses such as the Sharing and Technologies Incorporated Project, Simwon Technology, Ecojun Company, Underdogs, and the Farming Fund as well as by representatives from a social responsibility section of CJ management team and the social responsibility council of SK. In the future, these talks will serve as a medium to share their experiences in social businesses and to discuss the role of technology in the business. Some talks touched upon topics such as development of platforms for social innovation, social businesses employing disabled workers, and crowd funding for farming.
The Director of RISTI, Professor HongKyu Lee said, “The symposium will be the first to have people from leading companies in social businesses in Korea in one place.” He added, “This will be a great opportunity for anyone to know what will be the future of social businesses, which were created to solve the social problems caused by capitalism.”
The symposium was sponsored by the Ministry of Trade, Industry, and Energy of Korea.
2015.10.30 View 7492 -
Professors Sukbok Chang and Jang-Wook Choi Receive the 2015 Knowledge Award from the Korean Government
The Ministry of Science, ICT and Future Planning (MISP) of the Republic of Korea announced the 2015 Knowledge Awards on October 20, 2015. Two KAIST professors received the award.
Established in 2009, the awards are presented to Korean scientists whose publications have contributed to the international science community. Specifically, the MISP used the two biggest science databases, Science Citation Index Expanded (SCIE) and Scopus, to identify ten highly cited papers ranked in the top 1% by total citations in the past ten years.
Professor Sukbok Chang of Chemistry (left in the picture below) is a global authority in the field of catalytic hydrocarbon functionalization. His paper entitled “Palladium-catalyzed C-H Functionalization of Pyridine N-Oxides: Highly Selective Alkenylation and Direct Arylation with Unactivated Arenes,” which was published in the Journal of the American Chemical Society in 2008, was once selected by Thomson Reuters as one of the “Most Influential Research Papers of the Month.” In 2011, the American Chemical Society included his paper in the list of the top 20 research papers that were most frequently cited in the last three years.
Professor Jang-Wook Choi of the Graduate School of EEWS (Energy, Environment, Water, and Sustainability) has been known for his leading research in rechargeable battery, supercapacitor, and materials chemistry. In particular, his work on secondary fuel cells attracted significant attention from academia and industry in Korea. Professor Choi developed a super-thin flexible lithium-ion battery this year, thinner than a credit card, which lasts longer than the existing batteries and with greater performance. He also developed new electrode materials for next-generation sodium-ion and magnesium secondary fuel cells.
Professor Sukbok Chang (left) and Professor Jang-Wook Choi (right)
2015.10.23 View 9959 -
Mapping the Folding Process of a Single Membrane Protein
KAIST and UCLA scientists were able to observe an individual membrane protein fold and unfold by pulling and releasing magnetically trapped protein molecules.
Proteins are huge molecules containing hundreds to thousands of atoms that adopt a unique three dimensional structure, placing chemical groups in just the right place to catalyze reactions or build cellular structures. How all those atoms manage to find the right location - the so-called folding problem - has fascinated molecular biologists since the first structures were seen in the 1950s. Moreover, folding has important medical implications because most genetic defects cause protein misfolding.
About a third of all proteins float around in the cell membrane where they ensure the right chemicals get in the cell in the right amounts. Membrane proteins also provide key information links between the cell and its environment. Indeed, most drugs target membrane proteins. Nevertheless, the folding of membrane proteins has been particularly difficult to study and has rarely been studied in natural environments, leaving the folding process for a large fraction of the protein universe still largely cloaked in mystery.
In a recent issue of Nature Chemical Biology, published on October 19, 2015, a research team led by Tae-Young Yoon of the Department of Physics at the Korea Advanced Institute of Science and Technology (KAIST) and James U. Bowie of the Department of Chemistry and Biochemistry at the University of California, Los Angeles (UCLA), report a new method for manipulating the folding of membrane proteins in a membrane environment using a tool called a magnetic tweezer.
Researchers first attach long DNA handles to the ends of the protein. One handle is attached to a glass surface and the other to a magnetic bead. Using a magnet, they can essentially grab the protein and pull on it, inducing it to unfold. By playing with the bead attached to the protein, they can force the protein to unfold or allow it to refold, and watch all this happening by 3D-tracking of the magnetic bead. With this novel strategy, they were able to quantitatively map the folding energy landscape, the folding kinetic rate, and folding intermediates of a membrane protein in a membrane environment for the first time.
“I have been dreaming about this experiment for a decade. To see it work so well is really gratifying,” said Dr. Bowie.
One of the major surprises in the study was that essentially all the atoms of the protein jump into the correct structure together. The researchers expected that the protein structure would come together in a more piecemeal fashion, with different parts of the structure forming separately, but that was not the case. It is possible that nature evolved such a smooth, highly cooperative folding process to prevent partially folded forms that could get into trouble in the crowded cell membrane. On the other hand, the cooperative folding seen here might not apply to other membrane proteins.
“We need to look at more proteins. The technique developed here may allow us to do just that,” said Dr. Yoon.
The single molecule mechanical manipulation technique could enable detailed folding studies of many other membrane proteins. A major barrier to the study of membrane proteins previously is that the proteins tend to stick together and get tangled up, as computer cords lying at your feet tend to do. With the tweezer technique used in this work, the protein cords are held apart from other cords so they can’t get knotted up. It is hoped that the new approach will open up an important part of the protein universe to scrutiny, including many proteins that become misfolded in disease states.
The title of the research paper is “Mapping the energy landscape for second-stage folding of a single membrane protein” (DOI: 10.1038/nchembio.1939).
Picture: Single-molecule magnetic tweezers that induce mechanical unfolding and refolding of a single membrane protein. Since the force applied is parallel to the biological lipid membrane, the unfolding and refolding processes occur within the membrane.
2015.10.20 View 9261 -
Establishment of System Metabolic Engineering Strategies
Although conventional petrochemical processes have generated chemicals and materials which have been useful to mankind, they have also triggered a variety of environmental problems including climate change and relied too much on nonrenewable natural resources. To ameliorate this, researchers have actively pursued the development of industrial microbial strains around the globe in order to overproduce industrially useful chemicals and materials from microbes using renewable biomass. This discipline is called metabolic engineering.
Thanks to advances in genetic engineering and our knowledge of cellular metabolism, conventional metabolic engineering efforts have succeeded to a certain extent in developing microbial strains that overproduce bioproducts at an industrial level. However, many metabolic engineering projects launched in academic labs do not reach commercial markets due to a failure to fully integrate industrial bioprocesses.
In response to this, Distinguished Professor Sang Yup Lee and Dr. Hyun Uk Kim, both from the Department of Chemical and Biomolecular Engineering at KAIST, have recently suggested ten general strategies of systems metabolic engineering to successfully develop industrial microbial strains. Systems metabolic engineering differs from conventional metabolic engineering by incorporating traditional metabolic engineering approaches along with tools of other fields, such as systems biology, synthetic biology, and molecular evolution.
The ten strategies of systems metabolic engineering have been featured in Nature Biotechnology released online in October 2015, which is entitled "Systems strategies for developing industrial microbial strains."
The strategies cover economic, state-of-the-art biological techniques and traditional bioprocess aspects. Specifically, they consist of: 1) project design including economic evaluation of a target bioproduct; 2) selection of host strains to be used for overproduction of a bioproduct; 3) metabolic pathway reconstruction for bioproducts that are not naturally produced in the selected host strains; 4) increasing tolerance of a host strain against the bioproduct; 5) removing negative regulatory circuits in the microbial host limiting overproduction of a bioproduct; 6) rerouting intracellular fluxes to optimize cofactor and precursor availability necessary for the bioproduct formation; 7) diagnosing and optimizing metabolic fluxes towards product formation; 8) diagnosis and optimization of microbial culture conditions including carbon sources; 9) system-wide gene manipulation to further increase the host strain's production performance using high-throughput genome-scale engineering and computational tools; and 10) scale-up fermentation of the developed strain and diagnosis for the reproducibility of the strain's production performance.
These ten strategies were articulated with successful examples of the production of L-arginine using Corynebacterium glutamicum, 1,4-butanediol using Escherichia coli, and L-lysine and bio-nylon using C. glutamicum.
Professor Sang Yup Lee said, "At the moment, the chance of commercializing microbial strains developed in academic labs is very low. The strategies of systems metabolic engineering outlined in this analysis can serve as guidelines when developing industrial microbial strains. We hope that these strategies contribute to improving opportunities to commercialize microbial strains developed in academic labs with drastically reduced costs and efforts, and that a large fraction of petroleum-based processes will be replaced with sustainable bioprocesses."
Lee S. Y. & Kim, H. U. Systems Strategies for Developing Industrial Microbial Strains. Nature Biotechnology (2015).
This work was supported by the Technology Development Program to Solve Climate Change on Systems Metabolic Engineering for Biorefineries (NRF-2012M1A2A2026556) and by the Intelligent Synthetic Biology Center through the Global Frontier Project (2011-0031963) from the Ministry of Science, ICT and Future Planning (MSIP), Korea, and through the National Research Foundation (NRF) of Korea. This work was also supported by the Novo Nordisk Foundation.
Picture: Concept of the Systems Metabolic Engineering Framework
(a) Three major bioprocess stages (b) Considerations in systems metabolic engineering to optimize the whole bioprocess. List of considerations for the strain development and fermentation contribute to improving microbial strain's production performance (red), whereas those for the separation and purification help in reducing overall operation costs by facilitating the downstream process (blue). Some of the considerations can be repeated in the course of systems metabolic engineering.
2015.10.19 View 9819 -
Professor Ki-Jun Jeong Wins the 2015 Dam Yeun Academic Award
The 11th Dam Yeun Academic Award presented by the Korean Society for Biotechnology and Bioengineering (KSBB) to a biologist under 45 years old went to Professor Ki-Jun Jeong of the Chemical and Biomolecular Engineering Department at KAIST.
The award ceremony took place on October 13, 2015, at the annual conference of KSBB held at Songdo Convensia in Incheon City.
Each year KSBB announces the recipient of the award based on the publications by researchers in the last five years at peer-reviewed international journals or KSBB Journal as well as the record of patent registration and technology transfers.
Professor Jeong is recognized for his pioneering research in protein, antibody, cellular engineering, and protein displays and chips.
2015.10.19 View 7758