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Nature Biotechnology Nominates Sang Yup Lee of KAIST for Top 20 Translational Researchers of 2014
Nature Biotechnology, recognized as the most prestigious journal in the field of biotechnology, has released today its list of the Top 20 Translational Researchers of 2014. Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering at KAIST (Korea Advanced Institute of Science and Technology) ranked seventh in the list. He is the only Asian researcher listed.
The journal, in partnership with IP Checkups, a patent analytics firm, presents an annual ranking of researchers based on their paper and patent output. The list includes, among others, each researcher’s most-cited patent in the past five years and their H index, a measurement to evaluate the impact of a researcher’s published work utilizing citation analysis. (More details can be found at http://www.nature.com/bioent/2015/150801/full/bioe.2015.9.html.)
American institutions made up the majority of the list, with 18 universities and research institutes, and the remainder was filled by KAIST in Korea and the Commonwealth Scientific and Industrial Research Organization (CSIRO) in Australia.
Globally known as a leading researcher in systems metabolic engineering, Professor Lee has published more than 500 journal papers and 580 patents. He has received many awards, including the Citation Classic Award, Elmer Gaden Award, Merck Metabolic Engineering Award, ACS Marvin Johnson Award, SIMB Charles Thom Award, POSCO TJ Park Prize, Amgen Biochemical Engineering Award, and the Ho Am Prize in Engineering.
2015.08.27 View 10736 -
KAIST and the Czech Academy of Sciences Agree to Cooperate
KAIST and the Czech Academy of Sciences (CAS) signed a memorandum of understanding in the office of KAIST’s president on August 11, 2015. Ten people from the two institutions, including President Steve Kang of KAIST and Chairman Jiří Drahoš of CAS participated in the signing ceremony.
Under the agreement, the two institutions will cooperate on establishing joint research programs, sharing up-to-date research outcomes, and medium-and long-term exchange of researchers.
Having more than 50 public laboratories all over the Czech Republic, the Czech Academy of Sciences is the largest research institution in the country. Its research body along with the staff has eight thousand members. The institution focuses on mathematics, physics, biotechnology, and social sciences while running its own Ph.D. program.
President Kang said, “I hope this signing will expand our cooperation with universities and research institutions in Eastern Europe.”
2015.08.18 View 4684 -
Dr. Hyundoo Hwang Receives a Tenured Position at Monterrey Institute of Technology and Higher Education
Hyundoo Hwang, a former graduate student in the Department of Bio & Brain Engineering at KAIST, has been granted a tenured position at the Monterrey Institute of Technology and Higher Education (ITSEM), Mexico.
Dr. Hwang received his bachelor’s, master’s, and doctoral degree at KAIST and started his professorship at Ulsan National Institute of Science & Technology (UNIST) in Korea. He continued his research in the United States as a professor at Georgia Institute of Technology. He has been acknowledged for the development of an advanced nanotechnology for the diagnosis of rare diseases and research in cell signals. He is one of the leading researchers in an international research project in microelectromechanical systems (MEMS) with participation by researchers from over ten countries. He has been active in commercializing biosensor technology in the U.S. and Mexico.
Since its establishment in 1943, ITSEM has grown to 33 campuses in 25 cities in Mexico. It is the largest university in Latin America with over 90,000 students (47% of its graduate students has oversea research experience). It recruits over 5,000 international students and professors every year.
Dr. Hwang will begin teaching at ITSEM as a professor in the Department of Biomedical Engineering (Ingeniería Biomédica) this fall. He will also conduct research in nano- and micro-technology as a member of Sensors and Devices research group.
Professor Gwang Hyun Cho, head of KAIST's Department of Bio and Brain Engineering said that Dr. Hwang’s tenure professorship at ITSEM demonstrated that the academic program at KAIST—from undergraduate to doctoral—was on par with the international standard. He hoped that more talents from the department would seek academic careers in internationally renowned universities around the world.
2015.08.13 View 7037 -
KAIST holds the 2015 KAIST-MIT-Technion International Symposium on Nano Science
The 2015 KAIST-MIT-Technion International Symposium on Nano Science was held on August 11, 2015 at the KAIST campus. The event took place under three subtopics: Materials for Production and Storage of Renewable Energy, Functional Materials, and Multiferroic Materials.
The joint symposium invited more than 300 experts in material science and engineering including ten speakers and panelists. From MIT (Massachusetts Institute of Technology), Professors Harry L. Tuller and Geoffrey S. Beach in the Department of Material Engineering, as well as Professor Gregory Rutledge in the Department of Chemical Engineering joined the symposium. Professor Avner Rothschild in the Department of Material Engineering and Professor Yair Ein-Eli in the Department of Chemical Engineering at Technion Institute of Technology in Israel also participated.
From KAIST, Professors Il-Doo Kim, Byong-Guk Park, and Yeon-Sik Jung in the Department of Materials Science and Engineering, Professor Chan-Ho Yang in the Department of Physics, and Professor Doh-Chang Lee in the Department of Chemical and Biomolecular Engineering spoke at the event. The list of topics included “Next Generation Lithium-Air Battery,” “Nano Materials for High Performance Energy Storage System,” and “Iron Oxide Nanoparticles Photoelectrode for the Conversion and Storage of Solar Energy.”
In its efforts to promote cooperation among the three universities, KAIST plans to send six students to MIT and one student to Technion for joint research.
Professor Il-Doo Kim, who organized the symposium said, “We believe this kind of international gathering will serve as an opportunity for scholars from leading universities to share their expertise in material science and help them better understand on the recent trends in nanoscience and its related technology.”
2015.08.12 View 8698 -
'Engineered Bacterium Produces 1,3-Diaminopropane'
A research team led by Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering at KAIST reported, for the first time, the production of 1,3-diaminopropane via fermentation of an engineered bacterium.
1,3-Diaminopropane is a three carbon diamine, which has a wide range of industrial applications including epoxy resin and cross-linking agents, as well as precursors for pharmaceuticals, agrochemicals, and organic chemicals. It can also be polymerized with dicarboxylic acids to make polyamides (nylons) for use as engineering plastics, medical materials, and adhesives.
Traditionally, 1,3-diaminopropane is derived from petroleum-based processes. In effort to address critical problems such as the depletion of petroleum and environmental issues inherent to the petroleum-based processes, the research team has developed an Escherichia coli (E. coli) strain capable of producing 1,3-diaminopropane. Using this technology, 1,3-diaminopropane can now be produced from renewable biomass instead of petroleum.
E. coli as found in nature is unable to produce 1,3-diaminopropane. Metabolic engineering, a technology to transform microorganisms into highly efficient microbial cell factories capable of producing chemical compounds of interest, was utilized to engineer the E. coli strain. First, naturally existing metabolic pathways for the biosynthesis of 1,3-diaminopropane were introduced into a virtual cell in silico to determine the most efficient metabolic pathway for the 1,3-diaminopropane production. The metabolic pathway selected was then introduced into an E. coli strain and successfully produced 1,3-diaminopropane for the first time in the world.
The research team applied metabolic engineering additionally, and the production titer of 1,3-diaminopropane increased about 21 fold. The Fed-batch fermentation of the engineered E. coli strain produced 13 grams per liter of 1,3-diaminoproapne. With this technology, 1,3-diaminopropane can be produced using renewable biomass, and it will be the starting point for replacing the current petroleum-based processes with bio-based processes.
Professor Lee said, “Our study suggested a possibility to produce 1,3-diaminopropane based on biorefinery. Further study will be done to increase the titer and productivity of 1,3-diaminopropane.”
This work was published online in Scientific Reports on August 11, 2015.
Reference: Chae, T.U. et al. "Metabolic engineering of Escherichia coli for the production of 1,3-diaminopropane, a three carbon diamine," Scientific Reports:
http://www.nature.com/articles/srep13040
This research was supported by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries from Ministry of Science, ICT and Future Planning (MSIP) through the National Research Foundation (NRF) of Korea.
Figure 1: Metabolic engineering strategies for 1,3-diaminopropane production using C4 pathway
Figure 2: Fed-batch fermentation profiles of two final engineered E. coli strains
2015.08.12 View 11254 -
KAIST Agrees to Cooperate with Three Hospitals in the Delivery of Emergency Medical Services
KAIST signed an agreement with three major hospitals in Korea, the National Police Hospital, Seoul National University Hospital in Bundang, and the Armed Forces Capital Hospital, to respond to national emergency situations such as the outbreak of epidemic diseases.
The signing ceremony for the agreement took place on July 27, 2015, at the JW Marriott Hotel in Seoul.
Under the agreement, the four institutions will cooperate in conducting research in basic medical science to develop treatments and vaccines, building a system to deliver emergency medical services including the establishment of preventive measures against epidemics, and providing emergency medical assistance to under-developed countries.
This agreement was initiated by the Institute of Disaster Studies at KAIST.
President Steve Kang of KAIST said, “Korean society has recently experienced the importance of building a network of medical intuitions and research universities to handle national emergency situations when Middle East Respiratory Syndrome hits the nation hard. We need to prepare for epidemics and biological disasters, and this agreement is the first step towards serving such need.”
From the left to the right in the picture are: President Hong-Soon Lee of the National Police Hospital, President Steve Kang of KAIST, President Myung-Chul Lee of the Armed Forces Capital Hospital, and President Ho-Sung Han of Seoul National University Hospital in Bundang.
2015.07.31 View 5189 -
Affordable Genetic Diagnostic Technique for Target DNA Analysis Developed
Professor Hyun-Gyu Park of the Department of Chemical and Biomolecular Engineering at KAIST has developed a technique to analyze various target DNAs using an aptamer, a DNA fragment that can recognize and bind to a specific protein or enzyme. This technique will allow the development of affordable genetic diagnoses for new bacteria or virus, such as Middle Ease Respiratory Syndrome (MERS). The research findings were published in the June issue of Chemical Communications, issued by the Royal Society of Chemistry in the United Kingdom. The paper was selected as a lead article of the journal.
The existing genetic diagnosis technique, based on molecular beacon probes, requires a new beacon probe whenever a target DNA mutates. As a result, it was costly to analyze various target DNA fragments. To address this problem, Professor Park’s team designed an aptamer that binds and deactivates DNA polymerase. The technique was used in reverse, so that the aptemer did not bind to the polymerase, maintaining its activated state, only if the target DNA was present. These probes are called TagMan probes.
The controlled activation and deactivation of DNA polymerase enables nucleic acid to elongate or dwindle, making it possible to measure fluorescence signals coming from TaqMan probes. This same probe can be used to detect various target DNAs, leading to the development of a new and sensitive genetic diagnostic technique.
Unlike the existing molecular beacon probe technique which requires a new probe for every target DNA, this new technique uses the same fluorescent TaqMan probe, which is cheaper and easier to detect a number of different target nucleic acid fragments. The application of this technique will make the process of identifying and detecting foreign DNAs from pathogens such as virus and bacteria more affordable and simple.
Professor Park said, “This technique will enable us to develop simpler diagnostic kits for new pathogens, such as MERS, allowing a faster response to various diseases. Our technology can also be applied widely in the field of genetic diagnostics.”
Picture: A schematic image of target nucleic acid extracted through the activation and deactivation of DNA polymerase
2015.07.31 View 10474 -
A Technology Holding Company Establishes Two Companies Based on Technologies Developed at KAIST
Mirae Holdings is a technology holding company created by four science and technology universities, KAIST, DIGIST (Daegu Gyeongbuk Institute of Science and Technology), GIST (Gwangju Institute of Science and Technology), and UNIST (Ulsan National Institute of Science and Technology) in 2014 to commercialize the universities’ research achievements. The company identifies promising technologies for commercialization, makes business plans, establishes venture capitals, and invests in startup companies.
Over the past year, Mirae Holdings has established two venture companies based on the technologies developed at KAIST. In September 2014, it founded Cresem Inc., a company used the anisotropic conductive film (ACF) bonding technology, which was developed by Professor Kyung-Wook Paik of the Material Science and Engineering Department at KAIST. Cresem provides a technology to bond electronic parts ultrasonically. The company is expected to have 860,000 USD worth of sales within the first year of its launching.
Last June, Mirae Holdings created another company, Doctor Kitchen, with the technology developed by Professor Gwan-Su Yi of the Bio and Brain Engineering Department at KAIST. Doctor Kitchen supplies precooked food, which helps diabetic patients regulate their diet. The company offers a personalized diet plan to customers so that they can effectively manage their disease and monitor their blood sugar level efficiently.
The Chief Executive Officer of Mirae Holdings, Young-Ho Kim, said, “We can assist KAIST researchers who aspire to create a company based on their research outcomes through various stages of startup services such as making business plans, securing venture capitals, and networking with existing businesses.”
Young-Ho Kim (left in the picture), the Chief Executive Officer of Mirae Holdings, holds a certificate of company registration with Sang-Min Oh (right in the picture), the Chief Executive Officer of Cresem.
Young-Ho Kim (left in the picture), the Chief Executive Officer of Mirae Holdings, holds a certificate of company registration with Jae-Yeun Park (right in the picture), the Chief Executive Officer of Dr. Kitchen.
2015.07.29 View 12970 -
International Undergraduate Conference ICISTS-KAIST 2015 and ICISTS-KAIST Public Colloquium Held on August 3, 2015 at KAIST
The ICISTS-KAIST 2015, an international conference organized by a student organization called the International Conference for the Integration of Science, Technology, and Society at KAIST, was held from August 3rd to 7th at the KAIST campus and ICC Hotel in Daejeon. This year’s conference theme was “Shaping the Future.” Over 300 undergraduate students from more than 20 countries joined the event. The conference offered opportunities to explore emerging issues in science and technology, particularly in the fields of robotics, medicine, and science communication.
Vitalic Buterin, a rising scientist who received the 2014 World Technology Award for his development of the Ethereum Project, and Alan Irwin, a renowned scholar in science communication at the Copenhagen Business School in Denmark, were invited as keynote speakers. The list of other speakers included Stefan Lorenz Sorgner, the Director and Co-founder of the Beyond Humanism Network; Wendell Wallach, a scholar at Yale University's Interdisciplinary Center for Bioethics; and Hideto Nakajima, a professor at the Department of History, Philosophy and Social Studies of Science and Technology at Tokyo Institute of Technology.
As part of the ICISTS-KAIST 2015, ICISTS also hosted a public colloquium on August 5, 2015 at the Science Hall in Daejeon National Science Museum. Ko San, the Director of TIDE Institute; Hyo-Joon Woo, the Chief Executive Officer of Fransen; and Dong-Il Jung, the Chief Executive Officer of iDrone participated as the speakers.
2015.07.29 View 7860 -
KAIST Undergraduates Organize the Largest Interdisciplinary Conference in Asia
The largest interdisciplinary conference in Asia hosted by KAIST undergraduates for students around the world will be held in KAIST. The organizing committee of International Conference for the Integration of Science, Technology and Society (ICISTS) will hold the ICISTS-KAIST 2015 in KAIST and Hotel ICC from August 3-7, 2015, with around 300 Korean and international participants.
ICISTS-KAIST was established in 2005 to provide an annual platform for students to discuss the integration and the convergence of science, technology and society, regardless of their academic background.
This year’s theme is "Shaping the Future" and the topics for the conference are robotics, medicine, and science communication.
The keynote speakers are Vitalic Buterin, the winner of the World Technology Award in 2014 for the co-creation and invention of Ethereum and Alan Irwin, a well-known scholar of science, technology and society as well as the Dean of Research at the Copenhagen Business School in Denmark.
Other notable speakers include Adam Marcus, a professor of Hematology and Medical Oncology, Emory University School of Medicine; Stefan Lorenz Sorgner, the Director and co-founder of Beyond Humanism Network; Hideto Nakajima, a professor in the Department of History, Philosophy and Social Studies of Science and Technology at Tokyo Institute of Technology; Wendell Wallach, a lecturer at the Yale University Interdisciplinary Center for Bioethics; Jinil Lee, a professor in the Division of Biological Science and Technology at Yonsei University; and Sangwook Kim, an editor of APCTP web journal Crossroads and a professor in the Department of Physics Education, Pusan National University.
Last year, more than 300 students from 50 different countries attended the ICISTS-KAIST 2014 as delegates to exchange their thoughts and ideas on science, technology, and society.
To register for the event, please visit www.icists.org.
2015.07.14 View 8447 -
KAIST and Sejong City Goverment Agree to Establish a Graduate School of Medical Science and Engineering
KAIST and the government of Sejong City will cooperate to establish a graduate school of medical science and engineering. On June 11, 2015, President Steve Kang of KAIST and Mayor Choon-Hee Lee of Sejong City signed a memorandum of understanding at the city hall of Sejong to establish the school.
Under the agreement, the two organizations will work out details to establish the graduate school in Sejong on such issues as administrative assistance, financial support, curriculum development, and the creation of an environment conducive to the growth of medical science.
President Kang said, “Once this graduate school is established, KAIST will be able to offer Korea and the world top-notch researchers in the field of medical science. I have high hopes that the school will produce high-impact research breakthroughs and lead in the advancement of interdisciplinary studies in biotechnology.”
In the picture below, President Steve Kang of KAIST (third from the left) holds the signed memorandum of understanding with Mayor Choon-Hee Lee of Sejong (fourth from the left).
2015.06.16 View 6961 -
KAIST Team Develops Flexible PRAM
Phase change random access memory (PRAM) is one of the strongest candidates for next-generation nonvolatile memory for flexible and wearable electronics. In order to be used as a core memory for flexible devices, the most important issue is reducing high operating current. The effective solution is to decrease cell size in sub-micron region as in commercialized conventional PRAM. However, the scaling to nano-dimension on flexible substrates is extremely difficult due to soft nature and photolithographic limits on plastics, thus practical flexible PRAM has not been realized yet.
Recently, a team led by Professors Keon Jae Lee and Yeon Sik Jung of the Department of Materials Science and Engineering at KAIST has developed the first flexible PRAM enabled by self-assembled block copolymer (BCP) silica nanostructures with an ultralow current operation (below one quarter of conventional PRAM without BCP) on plastic substrates. BCP is the mixture of two different polymer materials, which can easily create self-ordered arrays of sub-20 nm features through simple spin-coating and plasma treatments. BCP silica nanostructures successfully lowered the contact area by localizing the volume change of phase-change materials and thus resulted in significant power reduction. Furthermore, the ultrathin silicon-based diodes were integrated with phase-change memories (PCM) to suppress the inter-cell interference, which demonstrated random access capability for flexible and wearable electronics. Their work was published in the March issue of ACS Nano: "Flexible One Diode-One Phase Change Memory Array Enabled by Block Copolymer Self-Assembly."
Another way to achieve ultralow-powered PRAM is to utilize self-structured conductive filaments (CF) instead of the resistor-type conventional heater. The self-structured CF nanoheater originated from unipolar memristor can generate strong heat toward phase-change materials due to high current density through the nanofilament. This ground-breaking methodology shows that sub-10 nm filament heater, without using expensive and non-compatible nanolithography, achieved nanoscale switching volume of phase change materials, resulted in the PCM writing current of below 20 uA, the lowest value among top-down PCM devices. This achievement was published in the June online issue of ACS Nano: "Self-Structured Conductive Filament Nanoheater for Chalcogenide Phase Transition." In addition, due to self-structured low-power technology compatible to plastics, the research team has recently succeeded in fabricating a flexible PRAM on wearable substrates.
Professor Lee said, "The demonstration of low power PRAM on plastics is one of the most important issues for next-generation wearable and flexible non-volatile memory. Our innovative and simple methodology represents the strong potential for commercializing flexible PRAM."
In addition, he wrote a review paper regarding the nanotechnology-based electronic devices in the June online issue of Advanced Materials entitled "Performance Enhancement of Electronic and Energy Devices via Block Copolymer Self-Assembly."
Picture Caption:
Low-power nonvolatile PRAM for flexible and wearable memories enabled by (a) self-assembled BCP silica nanostructures and (b) self-structured conductive filament nanoheater.
2015.06.15 View 15385