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Efficient Methane C-H Bond Activated by KAIST and UPenn Teams
Professor Mu-Hyun Baik of the Chemistry Department at KAIST and his team collaborated with an international team to discover a novel chemical reaction, carbon-hydrogen borylation using methane, and their research results were published in the March 25th issue of Science.
For details, please refer to the following press release from the Institute for Basic Sciences (IBS) in Korea and the University of Pennsylvania in the United States.
Efficient Methane C-H Bond Activation Achieved for the First Time
The Institute for Basic Science, March 24, 2016
Penn Chemists Lay Groundwork for Countless New, Cleaner Uses of Methane
University of Pennsylvania, March 24, 2016
2016.03.25 View 9812 -
KAIST Team Develops Technology to Enable Unzipping of the Graphene Plane
Professor Sang-Wook Kim’s research team of the Material Science and Engineering Department has developed a technique, which enables unzipping of the graphene plane without uncontrollable damage. The research findings were published online on the January 22 issue of Nature Communications.
Graphene is a form of carbon in which its atoms form a honey-comb structure through chemical bonding. If this structure can be cut to a desired form, other carbon materials with nanostructure can be created. Many researchers have tried to obtain the accurate unzipping of graphene structures, but faced challenges doing so.
To break a very strong bond between carbon atoms, an equivalently strong chemical reaction must be induced. But the chemical reaction not only cuts out the desirable borders, but also damages the surrounding ones. Conventional techniques, which cut out graphene at once, damaged the chemical properties of the graphene structure after unzipping. This is similar to wearing out paper while manipulating it.
To solve this problem, the research team adopted “heteroatom doping.” The idea is similar to a sheet of paper being split following a groove drawn on the sheet. After making some regions of the structure unstable by doping other atoms such as nitrogen on a carbon plane, the regions are electrochemically stimulated to split the parts. Nitrogen or other atoms act as the groove on the grapheme plane.
The researchers finely controlled the amount of unzipping graphene by adjusting the amount of heteroatom dopants, from which they were able to create a quality nano graphene without any damage in its 2-dimensional crystalline structure. Using this technique, the researchers were able to obtain a capacitor with state-of-the-art energy transfer speed. The nano graphene can be combined with polymer, metal, and semiconductor nano molecules to form carbon composites.
Professor Kim said, “In order to commercialize this technique, heteroatom doping should be researched further. We plan to develop fabric-like carbon materials with excellent mechanical and electrical properties using this technique.”
Picture 1: Unzipped Carbon Nano Tube
Picture 2: Development of Nano Graphene from Carbon Nano Tube Using Heteroatom Dopants
Korean descriptions translated into English:
Unzipping Process of Graphene
Carbon Nano Tube → Nano Graphen
Heteroatom
This process is similar to a paper being split in two from a tiny hole punched therein.
2016.03.22 View 9079 -
Non-Natural Biomedical Polymers Produced from Microorganisms
KAIST researchers have developed metabolically engineered Escherichia coli strains to synthesize non-natural, biomedically important polymers including poly(lactate-co-glycolate) (PLGA), previously considered impossible to obtain from biobased materials.
Renewable non-food biomass could potentially replace petrochemical raw materials to produce energy sources, useful chemicals, or a vast array of petroleum-based end products such as plastics, lubricants, paints, fertilizers, and vitamin capsules. In recent years, biorefineries which transform non-edible biomass into fuel, heat, power, chemicals, and materials have received a great deal of attention as a sustainable alternative to decreasing the reliance on fossil fuels.
A research team headed by Distinguished Professor Sang Yup Lee of the Chemical and Biomolecular Engineering Department at KAIST has established a biorefinery system to create non-natural polymers from natural sources, allowing various plastics to be made in an environmentally-friendly and sustainable manner. The research results were published online in Nature Biotechnology on March 7, 2016. The print version will be issued in April 2016.
The research team adopted a systems metabolic engineering approach to develop a microorganism that can produce diverse non-natural, biomedically important polymers and succeeded in synthesizing poly(lactate-co-glycolate) (PLGA), a copolymer of two different polymer monomers, lactic and glycolic acid. PLGA is biodegradable, biocompatible, and non-toxic, and has been widely used in biomedical and therapeutic applications such as surgical sutures, prosthetic devices, drug delivery, and tissue engineering.
Inspired by the biosynthesis process for polyhydroxyalkanoates (PHAs), biologically-derived polyesters produced in nature by the bacterial fermentation of sugar or lipids, the research team designed a metabolic pathway for the biosynthesis of PLGA through microbial fermentation directly from carbohydrates in Escherichia coli (E. coli) strains.
The team had previously reported a recombinant E. coli producing PLGA by using the glyoxylate shunt pathway for the generation of glycolate from glucose, which was disclosed in their patents KR10-1575585-0000 (filing date of March 11, 2011), US08883463 and JP5820363. However, they discovered that the polymer content and glycolate fraction of PLGA could not be significantly enhanced via further engineering techniques. Thus, in this research, the team introduced a heterologous pathway to produce glycolate from xylose and succeeded in developing the recombinant E. coli producing PLGA and various novel copolymers much more efficiently.
In order to produce PLGA by microbial fermentation directly from carbohydrates, the team incorporated external and engineered enzymes as catalysts to co-polymerize PLGA while establishing a few additional metabolic pathways for the biosynthesis to produce a range of different non-natural polymers, some for the first time. This bio-based synthetic process for PLGA and other polymers could substitute for the existing complicated chemical production that involves the preparation and purification of precursors, chemical polymerization processes, and the elimination of metal catalysts.
Professor Lee and his team performed in silico genome-scale metabolic simulations of the E. coli cell to predict and analyze changes in the metabolic fluxes of cells which were caused by the introduction of external metabolic pathways. Based on these results, genes are manipulated to optimize metabolic fluxes by eliminating the genes responsible for byproducts formation and enhancing the expression levels of certain genes, thereby achieving the effective production of target polymers as well as stimulating cell growth.
The team utilized the structural basis of broad substrate specificity of the key synthesizing enzyme, PHA synthase, to incorporate various co-monomers with main and side chains of different lengths. These monomers were produced inside the cell by metabolic engineering, and then copolymerized to improve the material properties of PLGA. As a result, a variety of PLGA copolymers with different monomer compositions such as the US Food and Drug Administration (FDA)-approved monomers, 3-hydroxyburate, 4-hydroxyburate, and 6-hydroxyhexanoate, were produced. Newly applied bioplastics such as 5-hydroxyvalerate and 2-hydroxyisovalerate were also made.
The team employed a systems metabolic engineering application which, according to the researchers, is the first successful example of biological production of PGLA and several novel copolymers from renewable biomass by one-step direct fermentation of metabolically engineered E.coli.
Professor Lee said, “We presented important findings that non-natural polymers, such as PLGA which is commonly used for drug delivery or biomedical devices, were produced by a metabolically engineered gut bacterium. Our research is meaningful in that it proposes a platform strategy in metabolic engineering, which can be further utilized in the development of numerous non-natural, useful polymers.”
Director Ilsub Baek at the Platform Technology Division of the Ministry of Science, ICT and Future Planning of Korea, who oversees the Technology Development Program to Solve Climate Change, said, “Professor Lee has led one of our research projects, the Systems Metabolic Engineering for Biorefineries, which began as part of the Ministry’s Technology Development Program to Solve Climate Change. He and his team have continuously achieved promising results and been attracting greater interest from the global scientific community. As climate change technology grows more important, this research on the biological production of non-natural, high value polymers will have a great impact on science and industry.”
The title of the research paper is “One-step Fermentative Production of Poly(lactate-co-glycolate) from Carbohydrates in Escherichia coli (DOI: 10.1038/nbt.3485).” The lead authors are So Young Choi, a Ph.D. candidate in the Department of Chemical and Biomolecular Engineering at KAIST, and Si Jae Park, Assistant Professor of the Environmental Engineering and Energy Department at Myongji University. Won Jun Kim and Jung Eun Yang, both doctoral students in the Department of Chemical and Biomolecular Engineering at KAIST, also participated in the research.
This research was supported by the Technology Development Program to Solve Climate Change’s research project titled “Systems Metabolic Engineering for Biorefineries” from the Ministry of Science, ICT and Future Planning through the National Research Foundation of Korea (NRF-2012M1A2A2026556).
Figure: Production of PLGA and Other Non-Natural Copolymers
This schematic diagram shows the overall conceptualization of how metabolically engineered E. coli produced a variety of PLGAs with different monomer compositions, proposing the chemosynthetic process of non-natural polymers from biomass. The non-natural polymer PLGA and its other copolymers, which were produced by engineered bacteria developed by taking a systems metabolic engineering approach, accumulate in granule forms within a cell.
2016.03.08 View 12068 -
K-Glass 3 Offers Users a Keyboard to Type Text
KAIST researchers upgraded their smart glasses with a low-power multicore processor to employ stereo vision and deep-learning algorithms, making the user interface and experience more intuitive and convenient.
K-Glass, smart glasses reinforced with augmented reality (AR) that were first developed by KAIST in 2014, with the second version released in 2015, is back with an even stronger model. The latest version, which KAIST researchers are calling K-Glass 3, allows users to text a message or type in key words for Internet surfing by offering a virtual keyboard for text and even one for a piano.
Currently, most wearable head-mounted displays (HMDs) suffer from a lack of rich user interfaces, short battery lives, and heavy weight. Some HMDs, such as Google Glass, use a touch panel and voice commands as an interface, but they are considered merely an extension of smartphones and are not optimized for wearable smart glasses. Recently, gaze recognition was proposed for HMDs including K-Glass 2, but gaze cannot be realized as a natural user interface (UI) and experience (UX) due to its limited interactivity and lengthy gaze-calibration time, which can be up to several minutes.
As a solution, Professor Hoi-Jun Yoo and his team from the Electrical Engineering Department recently developed K-Glass 3 with a low-power natural UI and UX processor. This processor is composed of a pre-processing core to implement stereo vision, seven deep-learning cores to accelerate real-time scene recognition within 33 milliseconds, and one rendering engine for the display.
The stereo-vision camera, located on the front of K-Glass 3, works in a manner similar to three dimension (3D) sensing in human vision. The camera’s two lenses, displayed horizontally from one another just like depth perception produced by left and right eyes, take pictures of the same objects or scenes and combine these two different images to extract spatial depth information, which is necessary to reconstruct 3D environments. The camera’s vision algorithm has an energy efficiency of 20 milliwatts on average, allowing it to operate in the Glass more than 24 hours without interruption.
The research team adopted deep-learning-multi core technology dedicated for mobile devices. This technology has greatly improved the Glass’s recognition accuracy with images and speech, while shortening the time needed to process and analyze data. In addition, the Glass’s multi-core processor is advanced enough to become idle when it detects no motion from users. Instead, it executes complex deep-learning algorithms with a minimal power to achieve high performance.
Professor Yoo said, “We have succeeded in fabricating a low-power multi-core processer that consumes only 126 milliwatts of power with a high efficiency rate. It is essential to develop a smaller, lighter, and low-power processor if we want to incorporate the widespread use of smart glasses and wearable devices into everyday life. K-Glass 3’s more intuitive UI and convenient UX permit users to enjoy enhanced AR experiences such as a keyboard or a better, more responsive mouse.”
Along with the research team, UX Factory, a Korean UI and UX developer, participated in the K-Glass 3 project.
These research results entitled “A 126.1mW Real-Time Natural UI/UX Processor with Embedded Deep-Learning Core for Low-Power Smart Glasses” (lead author: Seong-Wook Park, a doctoral student in the Electrical Engineering Department, KAIST) were presented at the 2016 IEEE (Institute of Electrical and Electronics Engineers) International Solid-State Circuits Conference (ISSCC) that took place January 31-February 4, 2016 in San Francisco, California.
YouTube Link: https://youtu.be/If_anx5NerQ
Figure 1: K-Glass 3
K-Glass 3 is equipped with a stereo camera, dual microphones, a WiFi module, and eight batteries to offer higher recognition accuracy and enhanced augmented reality experiences than previous models.
Figure 2: Architecture of the Low-Power Multi-Core Processor
K-Glass 3’s processor is designed to include several cores for pre-processing, deep-learning, and graphic rendering.
Figure 3: Virtual Text and Piano Keyboard
K-Glass 3 can detect hands and recognize their movements to provide users with such augmented reality applications as a virtual text or piano keyboard.
2016.02.26 View 13265 -
KAIST Graduate Han Receives a 2016 PECASE Award
President Barack Obama of the United States (US) announced 105 recipients of the 2016 Presidential Early Career Awards for Scientists and Engineers (PECASE) on February 18. Among the awardees was a graduate from the Department of Electrical Engineering at KAIST.
Dr. Jin-Woo Han has worked as a research scientist at the National Aeronautics and Space Administration (NASA) Ames Research Center since graduating from KAIST in 2010. This year, he is the only awardee who received a doctoral degree from a Korean university to become a recipient of the highest honor bestowed by the US government on science and engineering professionals in the early stages of their independent research careers.
The awards ceremony will take place in early spring at the White House in Washington, D.C.
Dr. Han has been involved in the development of radiation tolerant semiconductor devices as well as radiation and gas sensors under Dr. Meyya Meyyappan, Chief Scientist of the Center for Nanotechnology at NASA Ames Research Center.
KAIST and the NASA Ames Research Center made a research collaboration agreement in 2008, under which KAIST has sent 12 post-doctoral fellows to the center to date.
The PECASE awards, established in 1996 by President Bill Clinton, are coordinated by the Office of Science and Technology Policy within the Executive Office of the US President. Awardees are selected for their pursuit of innovative research at the frontiers of science and technology and their commitment to community services as demonstrated through scientific leadership, public education, or community outreach.
2016.02.23 View 9956 -
Meditox Donates 600 Million KRW Scholarship
On February 17, a Korean biopharmaceutical company Meditox, headed by Chief Executive Officer (CEO) Hyun-Ho Jeong, signed a memorandum of understanding (MOU) with KAIST to establish the “Meditox Fellowship” and donated a total of 600 million Korean won (KRW) to the university to assist in promoting more scientists in the field of biology.
Meditox CEO Hyun-Ho Jeong, KAIST President Steve Kang, Dean of Life Science and Bioengineering College Jung-Hoe Kim, and Dean of the Department of Biological Sciences Byung-Ha Oh participated in the agreement ceremony.
According to the MOU, Meditox will donate 60,000,000 KRW over a ten year period, from which KAIST can draw on to grant scholarships for master’s and doctoral students.
The “Meditox Fellowship” will support promising and enthusiastic students whose finances limit their studies. The first scholarship students for 2016 were: Kwang-Uk Min, In-suk Yeo, Sung-ryung- Lee, Si-on Lee, and Jung-hyun Kim.
Meditox CEO Jeong, who graduated from KAIST’s Department of Biological Sciences, said, "I felt it was important to start the Meditox Fellowship at my alma mater to contribute to the cultivation of outstanding scientists in the field of biological sciences."
He also said that he would plan to launch projects that aim to support not only those who receive the scholarship but also the development of Korea’s biological sciences in general.
President Steve Kang (right) and Chief Executive Officer Hyun-Ho Jeong (left) of Meditox hold the signed memorandum of understanding together.
2016.02.18 View 10401 -
Symposium on Creative Education
KAIST and the Korea Society for Creativity and Application (KSCA) co-hosted a symposium on creative education on January 21, 2016 at the KAIST Business and Management College in Seoul. Along with the symposium, the two organizations also held the Korea "Theory of Inventive Problem Solving" (TRIZ) Festival 2016.
Around 200 experts from academia, industry, and research including Dong-Suk Kim, Dean of the KAIST College of Business and Management and Gui-Chan Park, Director of POSCO Group Academy, attended the symposium.
The event was organized to celebrate the foundation of KSCA and to increase social awareness of creative education and design-related thinking with a "TRIZ approach."
"TRIZ" stands for the “Theory of Inventive Problem Solving” in Russian. It is a problem-solving method based on logic and data, not intuition, which accelerates the project team’s ability to work out issues creatively. The "TRIZ approach" has been widely used among Korean companies including Samsung, LG, and POSCO as a means of boosting employees’ creativity.
The academic symposium was divided into a keynote speech, paper presentations from each field, and a poster fair.
Professor Dae-Sik Kim from KAIST delivered a keynote speech on “Neuroscience and Creativity,” offering a glimpse of the world from a neuroscience perspective. Jae-min Lee, a researcher at Samsung Electronics, provided an industrial case study, “Application of TRIZ for the Improvement of Refrigerator.” Professor Jung-Seok Hyun from Jeju University and Dr. Jung-Ho Shin from E-Triz System presented their application of TRIZ on “Limitless Imagination and Invention Class for the Elementary School Students.” Altogether, 36 other research papers and case studies were presented at the symposium.
Dr. Dong-ryul Yang, President of KSCA, said, “This academic symposium allows us to discuss a range of innovative case studies that utilize TRIZ in industrial and educational fields, from which we can learn good lessons and practices.”
2016.01.19 View 6746 -
Professor Joonho Choe Appointed as the President of the KSMCB
Professor Joonho Choe of the Biological Sciences Department at KAIST has been elected the 25th president of Korean Society for Molecular and Cellular Biology (KSMCB).
His presidency will last one year, beginning on January 1, 2016.
Established in 1989, the Society has served as the largest academic gathering in the field of life sciences, holding an international conference every fall. It has more than 12,400 fellows.
Professor Choe served as the vice president of KSMC as well as the editor of its journal, Molecules and Cells.
He said, “The 2016 International Conference of the KSMCB will take place on October 12-14, 2016 at the COEX Convention and Exhibition Hall in Seoul. This year, we are preparing 20 symposiums and will invite four international renowned keynote speakers in the field including a Nobel Laureate. We hope many people, students and young researchers in particular, from academia and industry will join the conference.”
Professor Choe received his doctoral degree from the University of California, Los Angeles (UCLA) after graduating from Seoul National University with his bachelor and master’s degrees.
2016.01.05 View 8675 -
Prof. Jae-Kyu Lee Campaigns on "Bright Internet" Worldwide
Professor Jae-Kyu Lee (pictured on the right) from the College of Business at KAIST is one step closer to fulfilling his dream of achieving the “Bright Internet,” a campaign that he first proposed as he became the president of the Association for Information Systems (AIS) in June 2015.
On December 12, 2015, Professor Lee signed a memorandum of understanding (MOU) at a convention center in Fort Worth, Texas, between the AIS and the International Telecommunication Union (ITU)—a specialized agency of the United Nations that is responsible for issues related to information and communication technologies—on a collaborative research and development program to make the Internet safer for everyone.
The MOU pursues building a trusted international information and communication technology (ICT) infrastructure by proposing telecommunication policies, developing international standards, and organizing interdisciplinary conferences.
The Bright Internet is an initiative to protect online users from cyber terrors, privacy breaches, and cyber-crimes. Further, it involves putting accountability to those who initiate or deliver cyber threats, thereby eliminating the possible source of Internet related crimes.
Following the MOU agreement, Prof. Lee delivered a speech on his campaign at the 2015 International Conference on Information Systems and received positive responses from the audience.
The Bright Internet campaign has been selected as visions of various ICT organizations worldwide including the Korea Society of Management Information System and the International Federation of Information Processing. KAIST and Tsinghua University in China adopted it as an academic topic for research and teaching.
Prof. Lee claimed that the Internet should be used in a manner based on the values of trust, ethics, and decorum. He further noted that it is important to build Internet environments that not only protect individuals from cyber threats or attacks, but also hold those who commit online crimes accountable for their actions.
2015.12.28 View 9599 -
KAIST Wins the Korea Donation for Education Awards 2015
KAIST received the grand prize for the university section at the Korea Donation for Education Awards 2015. The award ceremony took place at Seoul Plaza Hotel on December 15, 2015.
The Ministry of Education created the award in 2012 to raise awareness about the need for charitable donations for education and to encourage the public’s participation in such endeavors. Recipients have included private companies, public institutions, non-profit organizations, universities, and individuals who have made notable contributions to education, for example, by offering educational programs or fundraising for such programs throughout a year.
Many organizations within KAIST, including the KAIST Center of Donation for Education, the Midam Scholarship Committee, the Donation for Software Education Group, the Chalk Academy, KAIST Student Volunteers, and K-LET, have been collectively recognized for their efforts to develop educational materials and managing academic camps and programs.
In addition to the grand prize which KAIST won, the Ministry of Education gave Neung-In Jang, a student pursuing a social entrepreneurship MBA at KAIST, an award for his efforts to provide quality education to teenagers by establishing the Midam Scholarship Committee in 2009. The Scholarship aims to revitalize the culture of donation for education by offering free math and science classes to high school students who are less privileged and by inspiring other universities in Korea to follow suit the committee’s volunteering activities.
2015.12.22 View 9890 -
An App to Digitally Detox from Smartphone Addiction: Lock n' LOL
KAIST researchers have developed an application that helps people restrain themselves from using smartphones during meetings or social gatherings.
The app’s group limit mode enforces users to curtail their smartphone usage through peer-pressure while offering flexibility to use the phone in an emergency.
When a fake phone company released its line of products, NoPhones, a thin, rectangular-shaped plastic block that looked just like a smartphone but did not function, many doubted that the simulated smartphones would find any users. Surprisingly, close to 4,000 fake phones were sold to consumers who wanted to curb their phone usage.
As smartphones penetrate every facet of our daily lives, a growing number of people have expressed concern about distractions or even the addictions they suffer from overusing smartphones.
Professor Uichin Lee of the Department of Knowledge Service Engineering at the Korea Advanced Institute of Science and Technology (KAIST) and his research team have recently introduced a solution to this problem by developing an application, Lock n’ LoL (Lock Your Smartphone and Laugh Out Loud), to help people lock their smartphones altogether and keep them from using the phone while engaged in social activities such as meetings, conferences, and discussions.
Researchers note that the overuse of smartphones often results from users’ habitual checking of messages, emails, or other online contents such as status updates in social networking service (SNS). External stimuli, for example, notification alarms, add to smartphone distractions and interruptions in group interactions.
The Lock n’ LoL allows users to create a new room or join an existing room. The users then invite meeting participants or friends to the room and share its ID with them to enact the Group Limit (lock) mode. When phones are in the lock mode, all alarms and notifications are automatically muted, and users must ask permission to unlock their phones. However, in an emergency, users can access their phones for accumulative five minutes in a temporary unlimit mode.
In addition, the app’s Co-location Reminder detects and lists nearby users to encourage app users to limit their phone use. The Lock n’ LoL also displays important statistics to monitor users’ behavior such as the current week’s total limit time, the weekly average usage time, top friends ranked by time spent together, and top activities in which the users participated.
Professor Lee said,
“We conducted the Lock n’ LoL campaign throughout the campus for one month this year with 1,000 students participating. As a result, we discovered that students accumulated more than 10,000 free hours from using the app on their smartphones. The students said that they were able to focus more on their group activities. In an age of the Internet of Things, we expect that the adverse effects of mobile distractions and addictions will emerge as a social concern, and our Lock n’ LoL is a key effort to address this issue.”
He added, “This app will certainly help family members to interact more with each other during the holiday season.”
The Lock n’ LoL is available for free download on the App Store and Google Play: https://itunes.apple.com/lc/app/lock-n-lol/id1030287673?mt=8.
YouTube link: https://youtu.be/1wY2pI9qFYM
Figure 1: User Interfaces of Lock n’ LoL
This shows the final design of Lock n’ LoL, which consists of three tabs: My Info, Friends, and Group Limit Mode. Users can activate the limit mode by clicking the start button at the bottom of the screen.
Figure 2: Statistics of Field Deployment
This shows the deployment summary of Lock n’ LoL campaign in May 2015.
2015.12.17 View 10464 -
Professor Naehyuck Chang Appointed a 2015 Fellow by the ACM
The Association for Computing Machinery (ACM), the world’s largest educational and scientific computing society, released a list of its new fellows on December 8, 2015, the 2015 ACM Fellows.
Professor Naehyuck Chang of the School of Electrical Engineering at KAIST was among the 42 new members who became ACM Fellows in recognition of their contributions to the development and application of computing in areas from data management and spoken-language processing to robotics and cryptography.
Professor Chang is known for his leading research in power and energy optimization from embedded systems applications to large-scale energy systems such as device- and system-level power and energy measurement and estimation, liquid crystal display power reduction, dynamic voltage scaling, hybrid electrical energy storage systems, and photovoltaic cell arrays. He is the fourth Korean to be nominated an ACM Fellow.
Professor Chang is also a Fellow of the Institute of Electrical and Electronics Engineers (IEEE) and the Editor-in-Chief of the journal, ACM Transactions on Design Automation of Electronic Systems (TODAES). He served as the President of the ACM Special Interest Group on Design Automation in 2012.
Additional information about the ACM 2015 Fellows, go to http://www.acm.org/press-room/news-releases/2015/fellows-2015:
2015.12.11 View 9729