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Acoustic Graphene Plasmons Study Paves Way for Optoelectronic Applications
- The first images of mid-infrared optical waves compressed 1,000 times captured using a highly sensitive scattering-type scanning near-field optical microscope. - KAIST researchers and their collaborators at home and abroad have successfully demonstrated a new methodology for direct near-field optical imaging of acoustic graphene plasmon fields. This strategy will provide a breakthrough for the practical applications of acoustic graphene plasmon platforms in next-generation, high-performance, graphene-based optoelectronic devices with enhanced light-matter interactions and lower propagation loss. It was recently demonstrated that ‘graphene plasmons’ – collective oscillations of free electrons in graphene coupled to electromagnetic waves of light – can be used to trap and compress optical waves inside a very thin dielectric layer separating graphene from a metallic sheet. In such a configuration, graphene’s conduction electrons are “reflected” in the metal, so when the light waves “push” the electrons in graphene, their image charges in metal also start to oscillate. This new type of collective electronic oscillation mode is called ‘acoustic graphene plasmon (AGP)’. The existence of AGP could previously be observed only via indirect methods such as far-field infrared spectroscopy and photocurrent mapping. This indirect observation was the price that researchers had to pay for the strong compression of optical waves inside nanometer-thin structures. It was believed that the intensity of electromagnetic fields outside the device was insufficient for direct near-field optical imaging of AGP. Challenged by these limitations, three research groups combined their efforts to bring together a unique experimental technique using advanced nanofabrication methods. Their findings were published in Nature Communications on February 19. A KAIST research team led by Professor Min Seok Jang from the School of Electrical Engineering used a highly sensitive scattering-type scanning near-field optical microscope (s-SNOM) to directly measure the optical fields of the AGP waves propagating in a nanometer-thin waveguide, visualizing thousand-fold compression of mid-infrared light for the first time. Professor Jang and a post-doc researcher in his group, Sergey G. Menabde, successfully obtained direct images of AGP waves by taking advantage of their rapidly decaying yet always present electric field above graphene. They showed that AGPs are detectable even when most of their energy is flowing inside the dielectric below the graphene. This became possible due to the ultra-smooth surfaces inside the nano-waveguides where plasmonic waves can propagate at longer distances. The AGP mode probed by the researchers was up to 2.3 times more confined and exhibited a 1.4 times higher figure of merit in terms of the normalized propagation length compared to the graphene surface plasmon under similar conditions. These ultra-smooth nanostructures of the waveguides used in the experiment were created using a template-stripping method by Professor Sang-Hyun Oh and a post-doc researcher, In-Ho Lee, from the Department of Electrical and Computer Engineering at the University of Minnesota. Professor Young Hee Lee and his researchers at the Center for Integrated Nanostructure Physics (CINAP) of the Institute of Basic Science (IBS) at Sungkyunkwan University synthesized the graphene with a monocrystalline structure, and this high-quality, large-area graphene enabled low-loss plasmonic propagation. The chemical and physical properties of many important organic molecules can be detected and evaluated by their absorption signatures in the mid-infrared spectrum. However, conventional detection methods require a large number of molecules for successful detection, whereas the ultra-compressed AGP fields can provide strong light-matter interactions at the microscopic level, thus significantly improving the detection sensitivity down to a single molecule. Furthermore, the study conducted by Professor Jang and the team demonstrated that the mid-infrared AGPs are inherently less sensitive to losses in graphene due to their fields being mostly confined within the dielectric. The research team’s reported results suggest that AGPs could become a promising platform for electrically tunable graphene-based optoelectronic devices that typically suffer from higher absorption rates in graphene such as metasurfaces, optical switches, photovoltaics, and other optoelectronic applications operating at infrared frequencies. Professor Jang said, “Our research revealed that the ultra-compressed electromagnetic fields of acoustic graphene plasmons can be directly accessed through near-field optical microscopy methods. I hope this realization will motivate other researchers to apply AGPs to various problems where strong light-matter interactions and lower propagation loss are needed.” This research was primarily funded by the Samsung Research Funding & Incubation Center of Samsung Electronics. The National Research Foundation of Korea (NRF), the U.S. National Science Foundation (NSF), Samsung Global Research Outreach (GRO) Program, and Institute for Basic Science of Korea (IBS) also supported the work. Publication: Menabde, S. G., et al. (2021) Real-space imaging of acoustic plasmons in large-area graphene grown by chemical vapor deposition. Nature Communications 12, Article No. 938. Available online at https://doi.org/10.1038/s41467-021-21193-5 Profile: Min Seok Jang, MS, PhD Associate Professorjang.minseok@kaist.ac.krhttp://jlab.kaist.ac.kr/ Min Seok Jang Research GroupSchool of Electrical Engineering http://kaist.ac.kr/en/Korea Advanced Institute of Science and Technology (KAIST)Daejeon, Republic of Korea (END)
2021.03.16
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ACS Nano Special Edition Highlights Innovations at KAIST
- The collective intelligence and technological innovation of KAIST was highlighted with case studies including the Post-COVID-19 New Deal R&D Initiative Project. - KAIST’s innovative academic achievements and R&D efforts for addressing the world’s greatest challenges such as the COVID-19 pandemic were featured in ACS Nano as part of its special virtual issue commemorating the 50th anniversary of KAIST. The issue consisted of 14 review articles contributed by KAIST faculty from five departments, including two from Professor Il-Doo Kim from the Department of Materials Science and Engineering, who serves as an associate editor of the ACS Nano. ACS Nano, the leading international journal in nanoscience and nanotechnology, published a special virtual issue last month, titled ‘Celebrating 50 Years of KAIST: Collective Intelligence and Innovation for Confronting Contemporary Issues.’ This special virtual issue introduced KAIST’s vision of becoming a ‘global value-creative leading university’ and its progress toward this vision over the last 50 years. The issue explained how KAIST has served as the main hub for advanced scientific research and technological innovation in South Korea since its establishment in 1971, and how its faculty and over 69,000 graduates played a key role in propelling the nation’s rapid industrialization and economic development. The issue also emphasized the need for KAIST to enhance global cooperation and the exchange of ideas in the years to come, especially during the post-COVID era intertwined with the Fourth Industrial Revolution (4IR). In this regard, the issue cited the first ‘KAIST Emerging Materials e-Symposium (EMS)’, which was held online for five days in September of last year with a global audience of over 10,000 participating live via Zoom and YouTube, as a successful example of what academic collaboration could look like in the post-COVID and 4IR eras. In addition, the “Science & Technology New Deal Project for COVID-19 Response,” a project conducted by KAIST with support from the Ministry of Science and ICT (MSIT) of South Korea, was also introduced as another excellent case of KAIST’s collective intelligence and technological innovation. The issue highlighted some key achievements from this project for overcoming the pandemic-driven crisis, such as: reusable anti-virus filters, negative-pressure ambulances for integrated patient transport and hospitalization, and movable and expandable negative-pressure ward modules. “We hold our expectations high for the outstanding achievements and progress KAIST will have made by its centennial,” said Professor Kim on the background of curating the 14 review articles contributed by KAIST faculty from the fields of Materials Science and Engineering (MSE), Chemical and Biomolecular Engineering (CBE), Nuclear and Quantum Engineering (NQE), Electrical Engineering (EE), and Chemistry (Chem). Review articles discussing emerging materials and their properties covered photonic carbon dots (Professor Chan Beum Park, MSE), single-atom and ensemble catalysts (Professor Hyunjoo Lee, CBE), and metal/metal oxide electrocatalysts (Professor Sung-Yoon Chung, MSE). Review articles discussing materials processing covered 2D layered materials synthesis based on interlayer engineering (Professor Kibum Kang, MSE), eco-friendly methods for solar cell production (Professor Bumjoon J. Kim, CBE), an ex-solution process for the synthesis of highly stable catalysts (Professor WooChul Jung, MSE), and 3D light-patterning synthesis of ordered nanostructures (Professor Seokwoo Jeon, MSE, and Professor Dongchan Jang, NQE). Review articles discussing advanced analysis techniques covered operando materials analyses (Professor Jeong Yeong Park, Chem), graphene liquid cell transmission electron microscopy (Professor Jong Min Yuk, MSE), and multiscale modeling and visualization of materials systems (Professor Seungbum Hong, MSE). Review articles discussing practical state-of-the-art devices covered chemiresistive hydrogen sensors (Professor Il-Doo Kim, MSE), patient-friendly diagnostics and implantable treatment devices (Professor Steve Park, MSE), triboelectric nanogenerators (Professor Yang-Kyu Choi, EE), and next-generation lithium-air batteries (Professor Hye Ryung Byon, Chem, and Professor Il-Doo Kim, MSE). In addition to Professor Il-Doo Kim, post-doctoral researcher Dr. Jaewan Ahn from the KAIST Applied Science Research Institute, Dean of the College of Engineering at KAIST Professor Choongsik Bae, and ACS Nano Editor-in-Chief Professor Paul S. Weiss from the University of California, Los Angeles also contributed to the publication of this ACS Nano special virtual issue. The issue can be viewed and downloaded from the ACS Nano website at https://doi.org/10.1021/acsnano.1c01101. Image credit: KAIST Image usage restrictions: News organizations may use or redistribute this image,with proper attribution, as part of news coverage of this paper only. Publication: Ahn, J., et al. (2021) Celebrating 50 Years of KAIST: Collective Intelligence and Innovation for Confronting Contemporary Issues. ACS Nano 15(3): 1895-1907. Available online at https://doi.org/10.1021/acsnano.1c01101 Profile: Il-Doo Kim, Ph.D Chair Professor idkim@kaist.ac.kr http://advnano.kaist.ac.kr Advanced Nanomaterials and Energy Lab. Department of Materials Science and Engineering Membrane Innovation Center for Anti-Virus and Air-Quality Control https://kaist.ac.kr/ Korea Advanced Institute of Science and Technology (KAIST) Daejeon, Republic of Korea (END)
2021.03.05
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Attachable Skin Monitors that Wick the Sweat Away
- A silicone membrane for wearable devices is more comfortable and breathable thanks to better-sized pores made with the help of citric acid crystals. - A new preparation technique fabricates thin, silicone-based patches that rapidly wick water away from the skin. The technique could reduce the redness and itching caused by wearable biosensors that trap sweat beneath them. The technique was developed by bioengineer and professor Young-Ho Cho and his colleagues at KAIST and reported in the journal Scientific Reports last month. “Wearable bioelectronics are becoming more attractive for the day-to-day monitoring of biological compounds found in sweat, like hormones or glucose, as well as body temperature, heart rate, and energy expenditure,” Professor Cho explained. “But currently available materials can cause skin irritation, so scientists are looking for ways to improve them,” he added. Attachable biosensors often use a silicone-based compound called polydimethylsiloxane (PDMS), as it has a relatively high water vapour transmission rate compared to other materials. Still, this rate is only two-thirds that of skin’s water evaporation rate, meaning sweat still gets trapped underneath it. Current fabrication approaches mix PDMS with beads or solutes, such as sugars or salts, and then remove them to leave pores in their place. Another technique uses gas to form pores in the material. Each technique has its disadvantages, from being expensive and complex to leaving pores of different sizes. A team of researchers led by Professor Cho from the KAIST Department of Bio and Brain Engineering was able to form small, uniform pores by crystallizing citric acid in PDMS and then removing the crystals using ethanol. The approach is significantly cheaper than using beads, and leads to 93.2% smaller and 425% more uniformly-sized pores compared to using sugar. Importantly, the membrane transmits water vapour 2.2 times faster than human skin. The team tested their membrane on human skin for seven days and found that it caused only minor redness and no itching, whereas a non-porous PDMS membrane did. Professor Cho said, “Our method could be used to fabricate porous PDMS membranes for skin-attachable devices used for daily monitoring of physiological signals.” “We next plan to modify our membrane so it can be more readily attached to and removed from skin,” he added. This work was supported by the Ministry of Trade, Industry and Energy (MOTIE) of Korea under the Alchemist Project. Image description: Smaller, more uniformly-sized pores are made in the PDMS membrane by mixing PDMS, toluene, citric acid, and ethanol. Toluene dilutes PDMS so it can easily mix with the other two constituents. Toluene and ethanol are then evaporated, which causes the citric acid to crystallize within the PDMS material. The mixture is placed in a mould where it solidifies into a thin film. The crystals are then removed using ethanol, leaving pores in their place. Image credit: Professor Young-Ho Cho, KAIST Image usage restrictions: News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only. Publication: Yoon, S, et al. (2021) Wearable porous PDMS layer of high moisture permeability for skin trouble reduction. Scientific Reports 11, Article No. 938. Available online at https://doi.org/10.1038/s41598-020-78580-z Profile: Young-Ho Cho, Ph.D Professor mems@kaist.ac.kr https://mems.kaist.ac.kr NanoSentuating Systems Laboratory Department of Bio and Brain Engineering https://kaist.ac.kr Korea Advanced Institute of Science and Technology (KAIST) Daejeon, Republic of Korea (END)
2021.02.22
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KAIST Celebrates 50-Year Anniversary with 2,712 New Graduates via 2021 Commencement Ceremony
KAIST is proud to announce the graduation of 2,712 students, including 668 PhDs and 1,331 master’s degree recipients. The pandemic could not stop the university from recognizing each graduate's remarkable and original achievements. A pandemic-proof blended commencement ceremony was held on Friday, February 19, and livestreamed to the graduates and their loved ones. KAIST decided to take extra precautions to protect graduates and other attendees’ health and well-being. For the virtual ceremony, only 83 out of the 2,712 graduates were invited to attend the ceremony in person. Graduates were divided into four groups to attend at four different places in Daejeon and Seoul campuses and watch the ceremony via Zoom. No family members or friends of the graduates were allowed to participate at the campus, but happily cheered the graduates via YouTube. This year’s valedictorian, Hyun-Young Park from the School of Electrical Engineering, received the Award of the Minister of Science and ICT. Salutorian Yeh-Lin Cho from the Department of Materials Science and Engineering received the Award of the KAIST Board of Trustees, while the recipient of the KAIST Presidential Award was Min-Jae Kim from the Department of Bio and Brain Engineering. The Award of the KAIST Development Foundation Chairman and the KAIST Alumni Association Presidential Award were conferred to Kyung-Tae Kim from the Department of Physics and Min-Woo Jung from the Department of Civil and Environmental Engineering, respectively. President Sung-Chul Shin, Chairman of the Board of Trustees Woo Sik Kim, and a very limited number of faculty members and administrative staff officiated the commencement ceremony from the KAIST Auditorium. President Shin applauded the graduates’ hard work and dedication in his commencement speech. He also delivered a very special congratulatory message to the bachelor’s degree awardees. “This year’s commencement is especially meaningful for me. I was appointed as the 16th president of KAIST on February 23, 2017, and met you for the first time on February 28 at the matriculation ceremony. We promised each other—as freshmen and as the first alumnus president—to do our best for the next four years,” President Shin recalled. He added, “I have done my best to keep my promise, and now my term will end on February 22. Of course, the past four years were even more precious because you were all a part of it.” In conclusion, President Shin said, “I am proud of you for keeping your end of the promise. Thank you for becoming who you are today. I have high hopes for the bright future that you will be shaping for KAIST and our society.” The livestream ceremony is archived for viewing on KAIST's Official YouTube Channel. (END)
2021.02.19
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A Biological Strategy Reveals How Efficient Brain Circuitry Develops Spontaneously
- A KAIST team’s mathematical modelling shows that the topographic tiling of cortical maps originates from bottom-up projections from the periphery. - Researchers have explained how the regularly structured topographic maps in the visual cortex of the brain could arise spontaneously to efficiently process visual information. This research provides a new framework for understanding functional architectures in the visual cortex during early developmental stages. A KAIST research team led by Professor Se-Bum Paik from the Department of Bio and Brain Engineering has demonstrated that the orthogonal organization of retinal mosaics in the periphery is mirrored onto the primary visual cortex and initiates the clustered topography of higher visual areas in the brain. This new finding provides advanced insights into the mechanisms underlying a biological strategy of brain circuitry for the efficient tiling of sensory modules. The study was published in Cell Reports on January 5. In higher mammals, the primary visual cortex is organized into various functional maps for neural tuning such as ocular dominance, orientation selectivity, and spatial frequency selectivity. Correlations between the topographies of different maps have been observed, implying their systematic organizations for the efficient tiling of sensory modules across cortical areas. These observations have suggested that a common principle for developing individual functional maps may exist. However, it has remained unclear how such topographical organizations could arise spontaneously in the primary visual cortex of various species. The research team found that the orthogonal organization in the primary visual cortex of the brain originates from the spatial organization in bottom-up feedforward projections. The team showed that an orthogonal relationship among sensory modules already exists in the retinal mosaics, and that this is mirrored onto the primary visual cortex to initiate the clustered topography. By analyzing the retinal ganglion cell mosaics data in cats and monkeys, the researchers found that the structure of ON-OFF feedforward afferents is organized into a topographic tiling, analogous to the orthogonal intersection of cortical tuning maps. Furthermore, the team’s analysis of previously published data collected on cats also showed that the ocular dominance, orientation selectivity, and spatial frequency selectivity in the primary visual cortex are correlated with the spatial profiles of the retinal inputs, implying that efficient tiling of cortical domains can originate from the regularly structured retinal patterns. Professor Paik said, “Our study suggests that the structure of the periphery with simple feedforward wiring can provide the basis for a mechanism by which the early visual circuitry is assembled.” He continued, “This is the first report that spatially organized retinal inputs from the periphery provide a common blueprint for multi-modal sensory modules in the visual cortex during the early developmental stages. Our findings would make a significant impact on our understanding the developmental strategy of brain circuitry for efficient sensory information processing.” This work was supported by the National Research Foundation of Korea (NRF). Image credit: Professor Se-Bum Paik, KAIST Image usage restrictions: News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only. Publication: Song, M, et al. (2021) Projection of orthogonal tiling from the retina to the visual cortex. Cell Reports 34, 108581. Available online at https://doi.org/10.1016/j.celrep.2020.108581 Profile: Se-Bum Paik, Ph.D Assistant Professor sbpaik@kaist.ac.kr http://vs.kaist.ac.kr/ VSNN Laboratory Department of Bio and Brain Engineering Program of Brain and Cognitive Engineering http://kaist.ac.kr Korea Advanced Institute of Science and Technology (KAIST) Daejeon, Republic of Korea Profile: Min Song Ph.D. Candidate night@kaist.ac.kr Program of Brain and Cognitive Engineering Profile: Jaeson Jang, Ph.D. Researcher jaesonjang@kaist.ac.kr Department of Bio and Brain Engineering, KAIST (END)
2021.01.14
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Electrosprayed Micro Droplets Help Kill Bacteria and Viruses
With COVID-19 raging around the globe, researchers are doubling down on methods for developing diverse antimicrobial technologies that could be effective in killing a virus, but harmless to humans and the environment. A recent study by a KAIST research team will be one of the responses to such efforts. Professor Seung Seob Lee and Dr. Ji-hun Jeong from the Department of Mechanical Engineering developed a harmless air sterilization prototype featuring electrosprayed water from a polymer micro-nozzle array. This study is one of the projects being supported by the KAIST New Deal R&D Initiative in response to COVID-19. Their study was reported in Polymer. The electrosprayed microdroplets encapsulate reactive oxygen species such as hydroxyl radicals, superoxides that are known to have an antimicrobial function. The encapsulation prolongs the life of reactive oxygen species, which enable the droplets to perform their antimicrobial function effectively. Prior research has already proven the antimicrobial and encapsulation effects of electrosprayed droplets. Despite its potential for antimicrobial applications, electrosprayed water generally operates under an electrical discharge condition, which can generate ozone. The inhalation of ozone is known to cause damage to the respiratory system of humans. Another technical barrier for electrospraying is the low flow rate problem. Since electrospraying exhibits the dependence of droplet size on the flow rate, there is a limit for the amount of water microdroplets a single nozzle can produce. With this in mind, the research team developed a dielectric polymer micro-nozzle array to perform the multiplexed electrospraying of water without electrical discharge. The polymer micro-nozzle array was fabricated using the MEMS (Micro Electro-Mechanical System) process. According to the research team, the nozzle can carry five to 19 micro-nozzles depending on the required application. The high aspect ratio of the micro-nozzle and an in-plane extractor were proposed to concentrate the electric field at the tip of the micro-nozzle, which prevents the electrical discharge caused by the high surface tension of water. A micro-pillar array with a hydrophobic coating around the micro-nozzle was also proposed to prevent the wetting of the micro-nozzle array. The polymer micro-nozzle array performed in steady cone jet mode without electrical discharge as confirmed by high-speed imaging and nanosecond pulsed imaging. The water microdroplets were measured to be in the range of six to 10 μm and displayed an antimicrobial effect on Escherichia coli and Staphylococcus aureus. Professor Lee said, “We believe that this research can be applied to air conditioning products in areas that require antimicrobial and humidifying functions.” Publication: Jeong, J. H., et al. (2020) Polymer micro-atomizer for water electrospray in the cone jet mode. Polymer. Vol. No. 194, 122405. Available online at https://doi.org/10.1016/j.polymer.2020.122405 Profile: Seung Seob Lee, Ph.D. sslee97@kaist.ac.kr http://mmst.kaist.ac.kr/ Professor Department of Mechanical Engineering (ME) Korea Advanced Institute of Science and Technology (KAIST) https://www.kaist.ac.kr Daejeon 34141, Korea Profile: Ji-hun Jeong, Ph.D. jiuni6022@kaist.ac.kr Postdoctoral researcher Department of Mechanical Engineering (ME) Korea Advanced Institute of Science and Technology (KAIST) https://www.kaist.ac.kr Daejeon 34141, Korea (END)
2020.12.21
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Dongwon Chairman Donates ₩50 Billion to Fund AI Graduate School
Dongwon Group Honorary Chairman and Founder Jae-chul Kim donated his private property worth ₩50 billion (US $46 million) to KAIST on December 16. Honorary Chairman Kim’s gift will fund the KAIST Graduate School of AI (GSAI), which was established last year. The KAIST GSAI will be re-named the ‘Kim Jae-chul Graduate School of AI’ to honor Honorary Chairman Kim. This is the third major donation that KAIST has received this year following KAIST Development Foundation Chairman Soo-Young Lee’s ₩67.6 billion in real estate in July and another ₩10 billion from a KAIST alumnus, Chairman Byeong-Gyu Chang of Krafton, in January. “KAIST, as the cradle that trains Korea’s best talents in science and technology, has been at the forefront of leading national development over the past 50 years. I hope that KAIST will also strive to nurture global talents who excel in AI innovation and steer Korea’s new advancements to lead the Fourth Industrial Revolution,” said Honorary Chairman Kim during the donation ceremony at KAIST’s main campus in Daejeon. The ceremony was held in strict compliance with Level Two social distancing guidelines and measures in response to the persistent coronavirus. Less than 50 people, including Honorary Chairman Kim’s family, President Sung-Chul Shin, and professors from key posts at KAIST, attended the ceremony. Dongwon Group is one of the leading fishery companies in Korea, established in 1969 by Honorary Chairman Kim. He recalled memories of his childhood as he explained the background of the donation, saying, “When I was young, I searched for Korea’s future in the world’s oceans. However, a new future lies in the ‘oceans of data.’” “I have been pondering how I could further contribute to my country, and realized that bringing up talented individuals in the AI and data science-related fields is important. I hope that my donation today will aid the take-off of KAIST’s great voyage towards becoming a global “flagship” in the new eras to come,” Honorary Chairman Kim added. To this, President Shin responded acclaiming the noblesse oblige held by Honorary Chairman Kim to further develop Korea’s science and technology and make Korea into a leader in AI innovation. “We will always keep KAIST’s role and mission close to our hearts and do our best to make KAIST into a global hub for talent cultivation and R&D in AI, based on Honorary Chairman Kim’s donation,” said President Shin. With Honorary Chairman Kim’s donation, the KAIST GSAI will first expand its faculty in both quantity and quality. By expanding the number of full-time, highly qualified professors to 40 by 2030, the School will train the most talented personnel in fusion and convergence AI. The KAIST GSAI opened in August 2019 as the first school in Korea to be selected as part of the ‘2019 Graduate School for AI Support Project’ by the Ministry of Science and ICT. The current faculty is composed of 13 full-time professors including ex-researchers from AI labs of global conglomerates including Google, IBM Watson, and Microsoft, as well as eight adjunct professors, making a total of 21 faculty members. There are currently 138 students attending the School, including 79 master’s students, 17 in the integrated MS-PhD program, and 42 PhD candidates. (END)
2020.12.16
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Mystery Solved with Math: Cytoplasmic Traffic Jam Disrupts Sleep-Wake Cycles
KAIST mathematicians and their collaborators at Florida State University have identified the principle of how aging and diseases like dementia and obesity cause sleep disorders. A combination of mathematical modelling and experiments demonstrated that the cytoplasmic congestion caused by aging, dementia, and/or obesity disrupts the circadian rhythms in the human body and leads to irregular sleep-wake cycles. This finding suggests new treatment strategies for addressing unstable sleep-wake cycles. Human bodies adjust sleep schedules in accordance with the ‘circadian rhythms’, which are regulated by our time keeping system, the ‘circadian clock’. This clock tells our body when to rest by generating the 24-hour rhythms of a protein called PERIOD (PER) (See Figure 1). The amount of the PER protein increases for half of the day and then decreases for the remaining half. The principle is that the PER protein accumulating in the cytoplasm for several hours enters the cell nucleus all at once, hindering the transcription of PER genes and thereby reducing the amount of PER. However, it has remained a mystery how thousands of PER molecules can simultaneously enter into the nucleus in a complex cell environment where a variety of materials co-exist and can interfere with the motion of PER. This would be like finding a way for thousands of employees from all over New York City to enter an office building at the same time every day. A group of researchers led by Professor Jae Kyoung Kim from the KAIST Department of Mathematical Sciences solved the mystery by developing a spatiotemporal and probabilistic model that describes the motion of PER molecules in a cell environment. This study was conducted in collaboration with Professor Choogon Lee’s group from Florida State University, where the experiments were carried out, and the results were published in the Proceedings of the National Academy of Sciences (PNAS) last month. The joint research team’s spatial stochastic model (See Figure 2) described the motion of PER molecules in cells and demonstrated that the PER molecule should be sufficiently condensed around the cell nucleus to be phosphorylated simultaneously and enter the nucleus together (See Figure 3 Left). Thanks to this phosphorylation synchronization switch, thousands of PER molecules can enter the nucleus at the same time every day and maintain stable circadian rhythms. However, when aging and/or diseases including dementia and obesity cause the cytoplasm to become congested with increased cytoplasmic obstacles such as protein aggregates and fat vacuoles, it hinders the timely condensation of PER molecules around the cell nucleus (See Figure 3 Right). As a result, the phosphorylation synchronization switch does not work and PER proteins enter into the nucleus at irregular times, making the circadian rhythms and sleep-wake cycles unstable, the study revealed. Professor Kim said, “As a mathematician, I am excited to help enable the advancement of new treatment strategies that can improve the lives of so many patients who suffer from irregular sleep-wake cycles. Taking these findings as an opportunity, I hope to see more active interchanges of ideas and collaboration between mathematical and biological sciences.” This work was supported by the National Institutes of Health and the National Science Foundation in the US, and the International Human Frontiers Science Program Organization and the National Research Foundation of Korea. Publication: Beesley, S. and Kim, D. W, et al. (2020) Wake-sleep cycles are severely disrupted by diseases affecting cytoplasmic homeostasis. Proceedings of the National Academy of Sciences (PNAS), Vol. 117, No. 45, 28402-28411. Available online at https://doi.org/10.1073/pnas.2003524117 Profile: Jae Kyoung Kim, Ph.D. Associate Professor jaekkim@kaist.ac.kr http://mathsci.kaist.ac.kr/~jaekkim @umichkim on Twitter Department of Mathematical Sciences Korea Advanced Institute of Science and Technology (KAIST) Daejeon, Republic of Korea Profile: Choogon Lee, Ph.D. Associate Professor clee@neuro.fsu.edu https://med.fsu.edu/biosci/lee-lab Department of Biomedical Sciences Florida State University Florida, USA (END)
2020.12.11
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Researchers Control Multiple Wavelengths of Light from a Single Source
KAIST researchers have synthesized a collection of nanoparticles, known as carbon dots, capable of emitting multiple wavelengths of light from a single particle. Additionally, the team discovered that the dispersion of the carbon dots, or the interparticle distance between each dot, influences the properties of the light the carbon dots emit. The discovery will allow researchers to understand how to control these carbon dots and create new, environmentally responsible displays, lighting, and sensing technology. Research into nanoparticles capable of emitting light, such as quantum dots, has been an active area of interest for the last decade and a half. These particles, or phosphors, are nanoparticles made out of various materials that are capable of emitting light at specific wavelengths by leveraging quantum mechanical properties of the materials. This provides new ways to develop lighting and display solutions as well as more precise detection and sensing in instruments. As technology becomes smaller and more sophisticated, the usage of fluorescent nanoparticles has seen a dramatic increase in many applications due to the purity of the colors emitting from the dots as well as their tunability to meet desired optical properties. Carbon dots, a type of fluorescent nanoparticles, have seen an increase in interest from researchers as a candidate to replace non-carbon dots, the construction of which requires heavy metals that are toxic to the environment. Since they are made up of mostly carbon, the low toxicity is an extremely attractive quality when coupled with the tunability of their inherent optical properties. Another striking feature of carbon dots is their capability to emit multiple wavelengths of light from a single nanoparticle. This multi-wavelength emission can be stimulated under a single excitation source, enabling the simple and robust generation of white light from a single particle by emitting multiple wavelengths simultaneously. Carbon dots also exhibit a concentration-dependent photoluminescence. In other words, the distance between individual carbon dots affects the light that the carbon dots subsequently emit under an excitation source. These combined properties make carbon dots a unique source that will result in extremely accurate detection and sensing. This concentration-dependency, however, had not been fully understood. In order to fully utilize the capabilities of carbon dots, the mechanisms that govern the seemingly variable optical properties must first be uncovered. It was previously theorized that the concentration-dependency of carbon dots was due to a hydrogen bonding effect. Now, a KAIST research team, led by Professor Do Hyun Kim of the Department of Chemical and Biomolecular Engineering has posited and demonstrated that the dual-color-emissiveness is instead due to the interparticle distances between each carbon dot. This study was made available online in June 2020 ahead of final publication in the 36th Issue of Physical Chemistry Chemical Physics on September 28, 2020. First author of the paper, PhD candidate Hyo Jeong Yoo, along with Professor Kim and researcher Byeong Eun Kwak, examined how the relative light intensity of the red and blue colors changed when varying the interparticle distances, or concentration, of the carbon dots. They found that as the concentration was adjusted, the light emitted from the carbon dots would transform. By varying the concentration, the team was able to control the relative intensity of the colors, as well as emit them simultaneously to generate a white light from a single source (See Figure). “The concentration-dependence of the photoluminescence of carbon dots on the change of the emissive origins for different interparticle distances has been overlooked in previous research. With the analysis of the dual-color-emission phenomenon of carbon dots, we believe that this result may provide a new perspective to investigate their photoluminescence mechanism,” Yoo explained. The newly analyzed ability to control the photoluminescence of carbon dots will likely be heavily utilized in the continued development of solid-state lighting applications and sensing. Publication: Yoo, H. J., Kwak, B. E., and Kim. D. H. (2020) Interparticle distance as a key factor for controlling the dual-emission properties of carbon dots. Physical Chemistry Chemical Physics, Issue 36, Pages 20227-20237. Available online at https://doi.org/10.1039/d0cp02120b Profile: Do Hyun Kim, Sc.D. Professor dokim@kaist.ac.kr http://procal.kaist.ac.kr/ Process Analysis Laboratory Department of Chemical and Biomolecular Engineering https://www.kaist.ac.kr Korea Advanced Institute of Science and Technology (KAIST)Daejeon, Republic of Korea (END)
2020.11.23
View 12714
‘WalkON Suit 4’ Releases Paraplegics from Wheelchairs
- KAIST Athletes in ‘WalkON Suit 4’ Dominated the Cybathlon 2020 Global Edition. - Paraplegic athletes Byeong-Uk Kim and Joohyun Lee from KAIST’s Team Angel Robotics won a gold and a bronze medal respectively at the Cybathlon 2020 Global Edition last week. ‘WalkON Suit 4,’ a wearable robot developed by the Professor Kyoungchul Kong’s team from the Department of Mechanical Engineering topped the standings at the event with double medal success. Kim, the former bronze medallist, clinched his gold medal by finishing all six tasks in 3 minutes and 47 seconds, whereas Lee came in third with a time of 5 minutes and 51 seconds. TWIICE, a Swiss team, lagged 53 seconds behind Kim’s winning time to be the runner-up. Cybathlon is a global championship, organized by ETH Zurich, which brings together people with physical disabilities to compete using state-of-the-art assistive technologies to perform everyday tasks. The first championship was held in 2016 in Zurich, Switzerland. Due to the COVID-19 pandemic, the second championship was postponed twice and held in a new format in a decentralized setting. A total of 51 teams from 20 countries across the world performed the events in their home bases in different time zones instead of traveling to Zurich. Under the supervision of a referee and timekeeper, all races were filmed and then reviewed by judges. KAIST’s Team Angel Robotics participated in the Powered Exoskeleton Race category, where nine pilots representing five nations including Korea, Switzerland, the US, Russia, and France competed against each other. The team installed their own arena and raced at the KAIST Main Campus in Daejeon according to the framework, tasks, and rules defined by the competition committee. The two paraplegic pilots were each equipped with exoskeletal devices, the WalkON Suit 4, and undertook six tasks related to daily activities. The WalkON Suit 4 recorded the fastest walking speed for a complete paraplegic ever reported. For a continuous walk, it achieved a maximum speed of 40 meters per minute. This is comparable to the average walking pace of a non-disabled person, which is around two to four kilometers per hour. The research team raised the functionality of the robot by adding technology that can observe the user’s level of anxiety and external factors like the state of the walking surface, so it can control itself intelligently. The assistive functions a robot should provide vary greatly with the environment, and the WalkON Suit 4 made it possible to analyze the pace of the user within 30 steps and provide a personally optimized walking pattern, enabling a high walking speed. The six tasks that Kim and Lee had to complete were:1) sitting and standing back up, 2) navigating around obstacles while avoiding collisions, 3) stepping over obstacles on the ground, 4) going up and down stairs, 5) walking across a tilted path, and 6) climbing a steep slope, opening and closing a door, and descending a steep slope. Points were given based on the accuracy of each completed task, and the final scores were calculated by adding all of the points that were gained in each attempt, which lasted 10 minutes. Each pilot was given three opportunities and used his/her highest score. Should pilots have the same final score, the pilot who completed the race in the shortest amount of time would win. Kim said in his victory speech that he was so thrilled to see all his and fellow researchers’ years of hard work paying off. “This will be a good opportunity to show how outstanding Korean wearable robot technologies are,” he added. Lee, who participated in the competition for the first time, said, “By showing that I can overcome my physical disabilities with robot technology, I’d like to send out a message of hope to everyone who is tired because of COVID-19”. Professor Kong’s team collaborated in technology development and pilot training with their colleagues from Angel Robotics Co., Ltd., Severance Rehabilitation Hospital, Yeungnam University, Stalks, and the Institute of Rehabilitation Technology. Footage from the competition is available at the Cybathlon’s official website. (END)
2020.11.20
View 12192
Drawing the Line to Answer Art’s Big Questions
- KAIST scientists show how statistical physics can reveal art trends across time and culture. - Algorithms have shown that the compositional structure of Western landscape paintings changed “suspiciously” smoothly between 1500 and 2000 AD, potentially indicating a selection bias by art curators or in art historical literature, physicists from the Korea Advanced Institute of Science and Technology (KAIST) and colleagues report in the Proceedings of the National Academy of Sciences (PNAS). KAIST statistical physicist Hawoong Jeong worked with statisticians, digital analysts and art historians in Korea, Estonia and the US to clarify whether computer algorithms could help resolve long-standing questions about design principles used in landscape paintings, such as the placement of the horizon and other primary features. “A foundational question among art historians is whether artwork contains organizing principles that transcend culture and time and, if yes, how these principles evolved over time,” explains Jeong. “We developed an information-theoretic approach that can capture compositional proportion in landscape paintings and found that the preferred compositional proportion systematically evolved over time.” Digital versions of almost 15,000 canonical landscape paintings from the Western renaissance in the 1500s to the more recent contemporary art period were run through a computer algorithm. The algorithm progressively divides artwork into horizontal and vertical lines depending on the amount of information in each subsequent partition. It allows scientists to evaluate how artists and various art styles compose landscape artwork, in terms of placement of a piece’s most important components, in addition to how high or low the landscape’s horizon is placed. The scientists started by analysing the first two partitioning lines identified by the algorithm in the paintings and found they could be categorized into four groups: an initial horizontal line followed by a second horizontal line (H-H); an initial horizontal line followed by a second vertical line (H-V); a vertical followed by horizontal line (V-H); or a vertical followed by a vertical line (V-V) (see image 1 and 2). They then looked at the categorizations over time. They found that before the mid-nineteenth century, H-V was the dominant composition type, followed by H-H, V-H, and V-V. The mid-nineteenth century then brought change, with the H-V composition style decreasing in popularity with a rise in the H-H composition style. The other two styles remained relatively stable. The scientists also looked at how the horizon line, which separates sky from land, changed over time. In the 16th century, the dominant horizon line of the painting was above the middle of the canvas, but it gradually descended to the lower middle of the canvas by the 17th century, where it remained until the mid-nineteenth century. After that, the horizon line began gradually rising again. Interestingly, the algorithm showed that these findings were similar across cultures and artistic periods, even through periods dominated by a diversity in art styles. This similarity may well be a function, then, of a bias in the dataset. “In recent decades, art historians have prioritized the argument that there is great diversity in the evolution of artistic expression rather than offering a relatively smoother consensus story in Western art,” Jeong says. “This study serves as a reminder that the available large-scale datasets might be perpetuating severe biases.” The scientists next aim to broaden their analyses to include more diverse artwork, as this particular dataset was ultimately Western and male biased. Future analyses should also consider diagonal compositions in paintings, they say. This work was supported by the National Research Foundation (NRF) of Korea. Publication: Lee, B, et al. (2020) Dissecting landscape art history with information theory. Proceedings of the National Academy of Sciences (PNAS), Vol. 117, No. 43, 26580-26590. Available online at https://doi.org/10.1073/pnas.2011927117 Profile: Hawoong Jeong, Ph.D. Professor hjeong@kaist.ac.kr https://www.kaist.ac.kr Department of Physics Korea Advanced Institute of Science and Technology (KAIST) Daejeon, Republic of Korea (END)
2020.11.13
View 13687
To Talk or Not to Talk: Smart Speaker Determines Optimal Timing to Talk
A KAIST research team has developed a new context-awareness technology that enables AI assistants to determine when to talk to their users based on user circumstances. This technology can contribute to developing advanced AI assistants that can offer pre-emptive services such as reminding users to take medication on time or modifying schedules based on the actual progress of planned tasks. Unlike conventional AI assistants that used to act passively upon users’ commands, today’s AI assistants are evolving to provide more proactive services through self-reasoning of user circumstances. This opens up new opportunities for AI assistants to better support users in their daily lives. However, if AI assistants do not talk at the right time, they could rather interrupt their users instead of helping them. The right time for talking is more difficult for AI assistants to determine than it appears. This is because the context can differ depending on the state of the user or the surrounding environment. A group of researchers led by Professor Uichin Lee from the KAIST School of Computing identified key contextual factors in user circumstances that determine when the AI assistant should start, stop, or resume engaging in voice services in smart home environments. Their findings were published in the Proceedings of the ACM on Interactive, Mobile, Wearable and Ubiquitous Technologies (IMWUT) in September. The group conducted this study in collaboration with Professor Jae-Gil Lee’s group in the KAIST School of Computing, Professor Sangsu Lee’s group in the KAIST Department of Industrial Design, and Professor Auk Kim’s group at Kangwon National University. After developing smart speakers equipped with AI assistant function for experimental use, the researchers installed them in the rooms of 40 students who live in double-occupancy campus dormitories and collected a total of 3,500 in-situ user response data records over a period of a week. The smart speakers repeatedly asked the students a question, “Is now a good time to talk?” at random intervals or whenever a student’s movement was detected. Students answered with either “yes” or “no” and then explained why, describing what they had been doing before being questioned by the smart speakers. Data analysis revealed that 47% of user responses were “no” indicating they did not want to be interrupted. The research team then created 19 home activity categories to cross-analyze the key contextual factors that determine opportune moments for AI assistants to talk, and classified these factors into ‘personal,’ ‘movement,’ and ‘social’ factors respectively. Personal factors, for instance, include: 1. the degree of concentration on or engagement in activities, 2. the degree urgency and busyness, 3. the state of user’s mental or physical condition, and 4. the state of being able to talk or listen while multitasking. While users were busy concentrating on studying, tired, or drying hair, they found it difficult to engage in conversational interactions with the smart speakers. Some representative movement factors include departure, entrance, and physical activity transitions. Interestingly, in movement scenarios, the team found that the communication range was an important factor. Departure is an outbound movement from the smart speaker, and entrance is an inbound movement. Users were much more available during inbound movement scenarios as opposed to outbound movement scenarios. In general, smart speakers are located in a shared place at home, such as a living room, where multiple family members gather at the same time. In Professor Lee’s group’s experiment, almost half of the in-situ user responses were collected when both roommates were present. The group found social presence also influenced interruptibility. Roommates often wanted to minimize possible interpersonal conflicts, such as disturbing their roommates' sleep or work. Narae Cha, the lead author of this study, explained, “By considering personal, movement, and social factors, we can envision a smart speaker that can intelligently manage the timing of conversations with users.” She believes that this work lays the foundation for the future of AI assistants, adding, “Multi-modal sensory data can be used for context sensing, and this context information will help smart speakers proactively determine when it is a good time to start, stop, or resume conversations with their users.” This work was supported by the National Research Foundation (NRF) of Korea. Publication: Cha, N, et al. (2020) “Hello There! Is Now a Good Time to Talk?”: Opportune Moments for Proactive Interactions with Smart Speakers. Proceedings of the ACM on Interactive, Mobile, Wearable and Ubiquitous Technologies (IMWUT), Vol. 4, No. 3, Article No. 74, pp. 1-28. Available online at https://doi.org/10.1145/3411810 Link to Introductory Video: https://youtu.be/AA8CTi2hEf0 Profile: Uichin Lee Associate Professor uclee@kaist.ac.kr http://ic.kaist.ac.kr Interactive Computing Lab. School of Computing https://www.kaist.ac.kr Korea Advanced Institute of Science and Technology (KAIST) Daejeon, Republic of Korea (END)
2020.11.05
View 14014
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