Department+of+Bio+and+Brain+Engineering
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Using Light to Deliver Drugs to the Brain
The cerebral blood vessels have a unique blood-brain barrier. Using this unique structure, Professor Choi Chul Hee (Department of Bio-Brain Engineering) developed a technique to deliver drugs safely to the brain using lasers to alter the diffusivity of the blood-brain barrier.
The blood-brain barrier allows the entry of only those drugs related to metabolic functions which made the entry of other drugs difficult.
Due to this property it was difficult to administer the drug to a patient and have it affect the patient. Therefore the question was is it possible to maintain the effectiveness of the drug and allow it to pass through the barrier?
The conventional method was to actually alter the structure of the drug or drill of small hole in the head and administering the drug directly, but these methods proved to be high risk and expensive.
Professor Choi’s team used an ultra-short frequency laser beam on the barrier for 1/1000th of a second on the barrier to temporarily inhibit its function thereby allowing the drug to enter the brain safely.
2011.06.20 View 8431 -
Professor Young-Ho Cho elected as head of international academic conference
KAIST’s Professor Young-Ho Cho of the Department of Bio and Brain Engineering was appointed as the head of the PowerMems (Power Micro Electro Mechanical Systems) symposium to be held at Se-Jong Hotel in Seoul from November 15-18, 2011.
Professor Jo is America’s first engineering doctor in the field of MEMS and is the founding member of the BSAC (Berkeley Sensor and Actuator Center), the start of the MEMS technology.
PowerMEMS is the core of green growth and next generation energy production. It focuses on harvesting energy from minute vibrations or renewable energy sources such as sunlight or plants to harvest and store energy via micro or even nano size systems.
The symposium was first held in 2000, and it is where leading experts in the field share papers on the production and harvesting energy in the micro scale.
2011.01.14 View 10347 -
Prof. Cho Elected Editor-in-Chief of Systems Biology
Prof. Kwang-Hyun Cho of Department of Bio and Brain Engineering at KAIST has been recently elected editor-in-chief of the Systems Biology, an international journal published by the London-based Institution of Engineering and Technology (IET), the university authorities said on Wednesday (Sept. 23)
By the year 2012, Cho will oversee the editorial process of the journal covering intra- and inter-cellular dynamics, using systems- and signal-oriented approaches. IET, one of the world"s leading professional societies for the engineering and technology community, has a worldwide membership of more than 150,000.
Prof. Cho"s research interests cover the areas of systems science with bio-medical applications including systems biology and bio-inspired engineering based on molecular systems biology. He is currently an editorial board member of Systems and Synthetic Biology (Springer, Netherlands, from 2006), BMC Systems Biology (BMC, London, U.K., from 2007), Gene Regulation and Systems Biology (Libertas Academica, New Zealand, from 2007), and Bulletin of Mathematical Biology (Springer, New York, from 2008), and an editorial advisory board member of Molecular BioSystems (The Royal Society of Chemistry, U.K.).
2009.09.24 View 14610 -
Prof. Cho Appointed Editor-in-Chief of Systems Biology Encyclopedia
Prof. Kwang-Hyun Cho of the Department of Bio and Brain Engineering, KAIST, has been appointed as the editor-in-chief of the Encyclopedia of Systems Biology which is currently in development by Springer, a New York-based publishing company, university authorities said on Monday (July 6).
Prof. Cho will share the position with three other eminent scholars from Britain, Germany and the United States. Cho will be responsible for selecting editorial members for each section of the Encyclopedia and overseeing the overall editorial process.
The Encyclopedia of Systems Biology is a multi-volume reference compilation of the research outcomes in the field of systems biology all over the world. The ESB will consist of alphabetically ordered description of systems biology concepts and is envisaged to ultimately comprise 6-12 volumes. Publication of the Encyclopedia is scheduled for 2011.
2009.07.08 View 12174 -
Workshop on Biomedical IC to Be Held on March 26
KAIST will hold a workshop on "biomedical IC for future healthcare system" on March 26 at a lecture room of the School of Electrical Engineering & Computer Science. The workshop is organized by SEECS and the Korean Institute of Next Generation Computing.
At the workshop, a variety of new technologies expected to expedite the development of biomedical systems will be presented. KAIST Prof. Hoi-Jun Yoo will speak on the "body channel communication" using the human body as the signal transmission medium and Dr. Seung-Hwan Kim of Electronics and Telecommunications Research Institute (ETRI) on a wearable vital sign monitoring system.
Other subjects are CMOS (complementary metal-oxide semiconductor) fully electronic biosensor for biomolecular detection to be presented by KAIST Prof. Gyu-Hyeong Cho; nerve interface and IC (integrated circuit) system design by KAIST Prof. Yoon-gi Nam; design of neural recording and stimulation IC using time-varying magnetic field by KAIST Prof. Seong-Hwan Cho; low power multi-core digital signal processor for hearing aid by Dong-Wook Kim, senior researcher at the Samsung Advanced Institute of Technology; and a non-contact cardiac sensor by KAIST Prof. Seung-Chul Hong.
With the advent of the ageing society, medical expenses of the elderly people are rapidly increasing. As a way to address the issue, interests are growing in "ubiquitous healthcare," a technology that uses a large number of environmental and patient sensors and actuators to monitor and improve patients’ physical and mental condition.
The upcoming workshop is the first academic event on biomedical integrated chips to be held in Korea. The workshop will provide a valuable opportunity for experts in biomedical area to get together and examine the present status of Korean biomedical area and discuss about its future, KAIST officials said.
2009.03.20 View 16553
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KAIST Wins First Prize at Recon Challenge of Int"l Magnetic Resonance Society
Professor Jong-chul Ye of the Department of Bio and Brain Engineering and Hong Jeong, a doctorate student, won the first prize at the Recon Challenge held as part of a workshop sponsored by the International Society for Magnetic Resonance in Medicine (ISMRM) held in Sedona, the United States.
The workshop took place under the theme of “data sampling and image reconstruction” on Jan. 25-28 in Sedona, Arizona, the United States. The KAIST team beat out major magnetic resonance imaging groups from the U.S. and Europe.
The Recon Challenge is a biennial competition highlighting different reconstruction strategies and metrics to compare them. ISMRM is an international, nonprofit, scientific association which promotes communication, research, development, and applications in the field of magnetic resonance in medicine and biology and other related topics.
At the competition, the KAIST team presented a new dynamic MRI algorithm called k-t FOCUSS that is optimal from a compressed sensing perspective. The main contribution of the method is extension of k-t FOCUSS to a more general framework with prediction and residual encoding. The prediction provides an initial estimate while the residual encoding takes care of the remaining residual signals.
2009.02.06 View 12804 -
Prof. Cho Identifies Dynamics of Signal Transportation System in Control of Cell Proliferation
KAIST, Jan. 22, 2009 -- A research team led by Prof. Kwang-Hyun Cho of the Department of Bio and Brain Engineering, KAIST, has identified a hidden mechanism of the dynamic behavior of signal transportation system involved in the control of cell proliferation, university authorities said.
The finding is expected to provide a clue to appropriately controlling the pathway of ERK protein which is known to play a significant role in causing and spreading cancer. The research was featured as the cover paper of the latest online edition of the Journal of Cell Science.
The Ras-Raf-MEK-ERK pathway (or ERK pathway) is an important signal transduction system involved in the control of cell proliferation, survival and differentiation. However, the dynamic regulation of the pathway by positive- and negative-feedback mechanism, in particular the functional role of Raf kinase inhibitor protein (RKIP) are still incompletely understood. RKIP is a physiological endogenous inhibitor of MEK phosphorylation by Raf kinases, but also participates in a positive-feedback loop in which ERK can inactivate RKIP.
"We attempted to unearth the hidden dynamics of these feedback mechanisms and to identify the functional role of RKIP through combined efforts of biochemical experiments and computer simulations based on an experimentally validated mechanical model," Prof. Cho was quoted as saying.
2009.02.03 View 11122 -
KAIST Opens Cell Bench Research Center
KAIST opened a cell bench research center on the campus on Monday, Nov. 17, as a joint project with Samsung Electric Co. and Samsung Medical Center.
On hand at the opening ceremony were about 100 persons from the three organizations, including KAIST President Nam-Pyo Suh, Samsung Electric"s Chief Technology Officer (CTO) Byung-Cheon Koh and Samsung Medical Center Vice President Hyo-Geun Lim.
The newly-opened research center will be involved in the development of individually-tailored anti-cancer medicine using bio-inspired cell chips and technologies for clinical applications. Prof. Young-Ho Cho of the Department of Bio and Brain Engineering was named director of the research center.
"Top-notch professionals from the electronic industry, academia and the medical community have gathered together to establish this research center. We expect the center will open a new path for the science and technology community and the industry to combine their strengths and develop innovative anti-cancer therapeutics," said KAIST President Nam-Pyo Suh at the opening ceremony.
"The development of bio-cell chip technology represents a new challenge for the Samsung Electric which has focused on information technologies thus far. Through cooperation with KAIST and Samsung Medical Center, we expect to be able to develop a simple and efficient cure for cancer patients," commented Samsung Electric CTO Byung-Cheon Koh.
The research center will be initially concentrating on the development of cell chips for lung cancer, one of the primary causes of death for Koreans.
2008.11.17 View 14816 -
KAIST Professor Named International Research Grant Reviewer
Prof. Kwang-Hyun Cho of the Department of Bio and Brain Engineering, KAIST, was appointed as a research grant review committee member of the international Human Frontier Science Program (HFSP) for 2008-2009, university authorities reported.
The HFSP is a funding agency that supports international collaboration in interdisciplinary, basic research in the life sciences. It was initiated in 1989 by G7 countries as the sole funding program for international researches in neuroscience and molecular biology. The HFSP now has a membership of 35 countries and Korea joined the program in 2004. Prof. Cho will be responsible for reviewing grant applications in the field of systems biology.
Prof. Cho received B.S., M.S. and Ph.D. degrees in electrical engineering from KAIST in 1993, 1995, and 1998, respectively. He has been working as a director of the KAIST Institute for the BioCentury and KAIST"s Laboratory for Systems Biology and Bio-Inspired Engineering. He has been serving on editorial advisory boards of various international science journals, including Systems and Synthetic Biology (Springer, Netherlands, from 2006), BMC Systems Biology (BMC, London, U.K., from 2007) and Gene Regulation and Systems Biology (Libertas Academica, New Zealand, from 2007).
He is a senior member of the Engineering in Medicine and Biology Society (EMBS) affiliated with the Institute of Electronics and Electrical Engineers (IEEE). His research interests cover the areas of systems science with bio-medical applications, especially systems biology and bio-inspired engineering based on molecular systems biology.
2008.07.18 View 17109 -
Int'l Conference for Integration of Science & Technology into Society Opens
The 2008 International Conference for the Integration of Science and Technology into Society (ICISTS-KAIST) opened a four-day meeting on Tuesday (July 15) at Daejeon KAIST campus. The conference is an annual event organized by a group of KAIST undergraduate students.
The fifth-year gathering is designed to provide participants with an opportunity to broaden their scientific perspectives by sharing ideas and experiences in related topics, as well as building an international human network. This year"s event has drawn about 200 students from 40 countries.
The centerpiece of the conference is three workshops on the following themes; Human-Robot Symbiotic Society, Neo-brain Science and Trafficmatics. Myung-Ja Kim, former Korean Environment Minister, will appear as a keynote speaker.
In the workshop sessions, two speakers will discuss specific issues and arrive at a tentative conclusion. Participants will have the opportunity to participate in the debate through Q&A for each session.
The first theme "Human-Robot Symbiotic Society" delves into the current trend that robot is being transformed into a perceivable and touchable concept from an abstract one. Guests for the workship include June-Ho Oh, professor at the Department of Mechanical Engineering, KAIST; James Dater, professor at the Department of Political Science, University of Hawaii at Manoa, and Director of the Hawaii Research Center for Future; Michael Pollitt, CEO of Shadow Robot Company; and Steven Dubowsky, professor at the Department of Mechanical Engineering, MIT.
The second theme "Neo-Brain Science" focuses on attempts to shed light on brain from diverse perspectives including psychology, economics and art. Among invited speakers are Prof. Jai-Seung Jung at the Department of Bio and Brain Engineering, KAIST; Prof. Un-Jung Kang at the University of Chicago Medical Center; and Peter Geyer, a consultant for the Association for Psychological Type.
The third workshop on "Traffimatics" will deal with "intelligent transport systems (ITS)" which will discusst new paradigm in transportation policy and traffic engineering. On the list of speakers are Assaf Biderman, assistant director, SENSEable City Laboratory, MIT; Prof. Richard Tay, at the Department of Civil Engineering, University of Calgary; Prof. Shoshi Mizokami at Kumamoto University; and Ho-Jong Baik, research associate professor of Virginia Tech.
2008.07.16 View 17264 -
World Micromachine Summit to Open in Daejeon
The 2008 World Micromachine Summit will be held at Hotel Riviera in Daejeon for a four-day run from April 30, drawing worldwide industrial and academic leaders in the micro-nano-technology (MNT).
Organizers say that 76 delegates and 56 observers from 19 countries and regions will take part in this year"s Micromachine Summit. Prof. Cho Young-ho of the Department of Bio & Brain Engineering of KAIST will play host to the annual event.
Participants will discuss the progress of micro-nano-technology in each country and region development of national policies in this area. The Summit was first organized in 1995 by the Micromachine Center of Japan with representatives from 10 countries participating. They were Australia, Canada, Germany, Italy, Japan, the Netherlands, Switzerland, the United Kingdom, and the United States.
Korea was first invited to the conference in 1999. Since then, Korea has played an active role in promoting technological exchanges among nations and has conducted presentations and discussions on major technological breakthroughs.
During the four-day run, each delegation will outline their country"s policies and strategies and present local features on focused areas including this year"s main theme, "Micromachine towards Technology Convergence Era."
The gathering will offer a valuable opportunity for the participants to exchange and collect information on the current state of the MNT, as well as providing a forum for worldwide networking of leaders in the area.
2008.04.29 View 12124 -
2008 Commencement Ceremony Held
The 2008 KAIST Commencement Ceremony was held on Feb. 29 at the KAIST Amphitheater in the presence of KAIST President Nam Pyo Suh, U.S. Ambassador to Korea Alexander Vershbow, alumni representatives and parents.
Other dignitaries on hand included National Assemblymen Sang-Kee Suh, Chang-Sun Hong and Sang-Min Lee; and Daejoen City Major Sung-Hyo Park.
President Suh and Vice President Soon-Heung Chang presented degrees to each of the 1,321 graduates (200 doctors, 725 masters and 396 bachelors) instead of just to representatives. Since its inception in 1971, KAIST has produced 7,067 Ph.D. graduates, 18,636 master"s degree holders and 8,998 bachelor"s degree holders. This year, 40 percent of the Ph.D. graduates, 79, were in their twenties upon graduation.
President Suh called on the graduates to return the favor they received from society by making their share of contributions to humanity. "You were chosen to be students of this unique university because the Korean people -- not only KAIST professors and staff, but also ordinary taxpayers -- believe that outstanding young people like you can change the world in which we live for the better. Now it is time for you to pay back their support," he said.
Notable graduates of this year include So-Yeon Yi, 29, the first Korean female astronaut candidate, who earned her doctorate degree in bio and brain engineering. She was granted a special award in recognition of her role in advancing space science in Korea but she could not attend the graduation ceremony due to her training schedule in Russia which will continue until April.
Eun-Gyu Oh, 26, was the youngest doctorate recipient in the ceremony and Won Hye-jeong, 21, recorded the top undergraduate GPA with a score of 4.20 over 4.3. Civil and environmental engineering major Seung-Hee Park, 28, published a total of eight papers in major international journals while attending KAIST and two more papers are currently under review.
So-Yeon Yi said: ``I frequently stayed up all night to research and write the paper. It was tough experience for me. Thanks to ceaseless support from professors and colleagues, however, I was able to complete the task,"" she said. ``I have done my best in studying, exercising and so on. I"m sure that my active, participatory attitude brought about this honorable moment.""
She is now training at Gagarin Cosmonaut Training Center near Moscow as a replacement astronaut in case Koh San, 31, who is to be the first Korean astronaut, is unable to go into orbit.
Koh and Yi were selected from more than 36,000 applicants last year. Koh was finally picked as the primary candidate last September. The two are serving as space ambassadors appointed by the Ministry of Science & Technology.
2008.03.09 View 14265