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Nobel Laureate Dr. John Michael Kosterlitz Speaks at KAIST
KAIST’s Department of Physics will invite one of three co-recipients of the Nobel Prize in Physics 2016, Professor John Michael Kosterlitz of Brown University, on January 9, 2017, to speak about the exotic states of matter, which is entitled “Topological Defects and Phase Transitions.” Professor Kosterlitz shares the Nobel award with two other researchers, David Thouless and Duncan Haldane. He is considered one of the pioneers in the field of topological phases. In the early 1970s, along with Thouless, he demonstrated that superconductivity could occur at low temperatures and explained the mechanism behind, phase transition, that makes superconductivity disappear at higher temperatures. Over the last decade, topological materials and their applications have been widely studied with the hope of using them in new generations of electronics and superconductors, or in future quantum computers. Details of the lecture follow below: Distinguished Lecture Series by KAIST’s Physics Department · Speaker: Professor John Michael Kosterlitz of the Physics Department, Brown University · Topic: “Topological Defects and Phase Transitions” · Date: January 9, 2017, 4:00 PM · Place: Lecture Hall (#1501), College of Natural Sciences (E6-2)
2017.01.06
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KAIST Undergraduates Win the Innovative Design Contest 2016
A team of KAIST students, consisting of five undergraduates (Do-Hoon Kwon, Tae-Hyun Kim, Hak-Gi Do, Hyun-Joo Lee, and Jong-Ho Jeong) from the Department of Mechanical Engineering, won the grand prize at the Innovative Design Contest held at Osaka University in Japan on December 12-13, 2016. The event took place during the 16th Asia Design Engineering Workshop (A-DEWS). For this year’s contest, a total of ten student teams from such countries as Korea, Japan, Taiwan, and Malaysia participated, and Team KAIST earned the highest scores. The five KAIST students, all taking the course entitled “Production of Creative Systems,” developed a manual wheelchair accessory called “Safe Attachable Wheelchair Assistive Device in Capstone Design (SAWADiCap). SAWADiCap is a detachable auxiliary power device that increases the range and mobility of manual wheelchairs. The device can easily be installed and removed, compared to existing add-on attachments for wheelchairs. Users can also enjoy similar advantages offered by powered wheelchairs at a lower cost. In their presentation on the device, the KAIST students introduced their design to improve the power of manual wheelchairs employing the magnetic reinforcement effect and to include the safety features necessary for users to install or operate the device. Do-Hoon Kwon said, “Our team had a great experience participating in the contest—we met people with diverse backgrounds and expanded our understanding in the field.” Professor Seibum B. Choi of the Mechanical Engineering Department, who advises the KAIST team, added, “I hope our technology can help the spread of affordable wheelchairs and increase mobility for the disabled.” Established in 2000, A-DEWS is held annually by the Asian branch of the Design Engineering Workshop to provide an international forum for researchers and practitioners in the field of design engineering by facilitating the exchange of recent research results and sharing knowledge about design strategies and methods. This year’s theme for the workshop was “Innovation of Life.” A-DEWS hosts the Innovative Design Contest to encourage young engineers, researchers, and students who are creating innovative products, services, and product-services and to show appreciation for their efforts. Pictured below from left to right are Hyun-Joo Lee, Do-Hoon Kwon, Jong-Ho Jeong, and Hak-Gi Do.
2017.01.03
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KAIST Ph.D. Candidate Wins the Next Generation of Engineers Award
Joo-Sung Kim, a doctoral student at the EEWS (Environment, Energy, Water and Sustainability) Graduate School won the inaugural Next Generation of Engineers Award in Leadership on December 14, 2016. The National Academy of Engineering of Korea hosts this award to support creative and ambitious students who have the potential to become leaders in engineering and who will serve as role models for future Korean engineers. Based on the recommendations of university professors in engineering and members of the academy, seven students are selected for the award in the categories of leadership and entrepreneurship. With his research focus on the development of high-performance, next-generation secondary cells for wearable devices such as smart watches, health bands, and smart eyewear, Joo-Sung created a startup, Lithium-ion Battery Energy Science and Technology (LiBEST), Inc. He plans to base his company at the Office of University and Industry Cooperation, KAIST, where he can receive assistance for launching the mass-production system for his technology. His adviser, Professor Jang-Wook Choi of the EEWS Graduate School, noted, “Joo-Sung has been a great student who has a strong sense of curiosity and perseverance. The award is the by-product of his hard work.” “I have always enjoyed my work and study as a researcher, but eventually would like to expand my career into business based on the results of my research. It would be wonderful if I could become a businessman like Elon Musk, Masayoshi Son, or Ma Yun and create a role model for aspiring engineers in Korea by combining science and technology with business demand to create social values that benefit many people,” Joo-Young said.
2016.12.26
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EEWS Graduate School Team Receives the S-Oil Best Paper Award
Professor Hyungjun Kim and Dr. He-Young Shin from the EEWS (Energy, Environment, Water and Sustainability) Graduate School at KAIST received the Best Paper Award in Chemistry from S-Oil, a Korean petroleum and refinery company, on November 29, 2016. Established in 2011, the S-Oil Best Paper Awards are bestowed annually upon ten young scientists in the fields of five basic sciences: mathematics, physics, chemistry, biology, and earth science. The scientists are selected at the recommendation of the Korean Academy of Science and Technology and the Association of Korean Universities. The awards grant a total of USD 230,000 for research funding. Dr. Shin, the lead author of the awarded research paper, said, “My research interest has been catalyst studies based on theoretical chemistry. I am pleased to accept this award that will support my studies, and will continue to research catalyst design that can predict parameters and integrate them into catalytic systems.” Professor Hyungjun Kim (left) and Dr. He-Young Shin (right)
2016.12.23
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The Antibody That Normalizes Tumor Vessels
Researchers also discover that their antisepsis antibody reduces glioma, lung and breast cancer progression in mice. A research team at the Center for Vascular Research within the Institute for Basic Science (IBS) discovered that the antisepsis antibody ABTAA (Ang2-Binding and Tie2-Activating Antibody) reduces tumor volume and improves the delivery of anti-cancer drugs. Published in Cancer Cell, this study demonstrates that ABTAA restores the structural and functional integrity of tumor blood vessels in three different tumor models: breast, lungs, and brain. Blood vessels inside and around an established tumor can be described as a chaotic and dysfunctional labyrinth. While the inner walls of healthy blood vessels are surrounded and supported by endothelial cells and other cells called pericytes, in the established tumor, the endothelial junctions are broken apart and pericytes are also detached. Blood flow into and from the tumor is severely retarded and tumor vessels lacking an intact vessel wall become leaky. This microenvironment causes limited drug delivery to the tumor and leads to inadequate oxygen supply (hypoxia) and even metastasis. The research team led by Professor Gou-Young Koh at KAIST’s Graduate School of Medical Science and Engineering found that the antibody ABTAA normalizes the tumor vessels and hence, change the whole tumor microenvironment. “We call it normalization of tumor vessels, because it resembles closely the wall architecture of healthy, normal vessels,” explains PARK Jin-Sung, first author of the study. And continues: “Tumor can adapt to hypoxia and get more aggressive, so we tried to prevent this transition by normalizing tumor vessels. ABTAA changes the whole tumor environment, oxygenation status and level of lactate, so that the immune cells and drugs can reach the core regions of the tumor more easily. In this way, we create a favorable ground for tumor treatment.” In an attempt to generate antibodies targeting the protein Ang2, which is specifically expressed by endothelial cells in stressful conditions like in tumor, the team unexpectedly discovered that ABTAA has a peculiar way of working and a dual function. ABTAA indeed not only blocks Ang2, but also activates Tie2 at the same time. Tie2 is a receptor present on the cell membrane of endothelial cells. ABTAA causes Ang2 to cluster together and to strongly activate Tie2 receptors. “If we activate Tie2, we can efficiently normalize tumor vessels, enhance drug delivery and change the whole microenvironment,” explains KOH Gou Young, Director of the Center for Vascular Research. Several pharmaceutical companies are developing Ang2-blocking antibodies to cure cancer. However, even if these antibodies significantly inhibit tumor progression, they do not stop tumor hypoxia. Moreover, most of the anti-cancer drugs target the tumor at its early stage, when tumors are still hard to diagnose. ABTAA, instead, works with tumors that are already rooted: “When the tumor is established, hypoxia is the main driver of tumor progression. So, if we eliminate hypoxia, we make the tumor milder, by reducing its progression and metastasis,” comments Koh. Figure: Schematic drawing of a blood vessel around tumors before and after treatment with ABTAA. The picture above shows a typical tumor vasculature characterized by damaged walls, red blood cells leakage and detached pericytes. Activating Tie2 on endothelial cells with the antibody ABTAA restores the normal vessel architecture: endothelial and pericytes on the vessel walls are stabilized, the delivery of blood is improved, and the anticancer drugs are more likely to reach the tumor core. The researchers tested ABTAA in mice with three different types of tumors that show high levels of Ang2: glioma (a type of a brain tumor), lung carcinoma, and breast cancer. They also compared the effect of ABTAA with ABA, another antibody that blocks Ang2 but misses the Tie2 activating properties. In all three cases, ABTAA was superior to ABA in inducing tumor vessel normalization, which led to a better delivery of the anti-cancer drugs into the tumor core region. Glioma is one of the so-called intractable diseases, because of its poor prognosis and treatment. Professor Koh’s team found that the glioma volume was reduced 39% by ABTAA and 17% by ABA. ABTAA profoundly reduced vascular leakage and edema formation in glioma through promoting vascular tightening. Moreover, when ABTAA was administered together with the chemotherapeutic drug temozolomide (TMZ), the tumor volume reduces further (76% by ABTAA+TMZ, 51% by ABA+TMZ, and 36% by TMZ). In the Lewis Lung Carcinoma (LLC) tumor model, the team administered ABTAA together with a chemotherapeutic drug called cisplatin (Cpt) and observed a greater suppression of tumor growth (52%) compared with the controls and increased overall survival. Moreover, ABTAA+Cpt led to a marked increase in necrotic area within tumors. Finally, in a spontaneous breast cancer model, ABTAA delayed tumor growth and enhanced the anti-tumor effect of Cpt. Courtesy of the Institute for Basic Sciences (IBS) Figure: The antibody ABTAA alone and in combination with other anti-cancer drugs have a beneficial effect in reducing tumor volume. ABTAA was tested in mice with brain tumor (glioma), lung or breast cancer. The image shows the improvements: reduction in glioma tumor size, reduction in metastatic colonies in lung tumor and decrease in necrotic regions in breast tumor. In the future, the team would like to further understand the underlying relationship between faulty blood vessels and diseases. “We would like to apply this antibody to an organ that is rich in blood vessels, that is the eye, and see if this antibody can be useful to treat eye diseases such as age-related macular degeneration and diabetic retinopathy,” concludes Koh. Professor Gou-Young Koh (left) and Jin-Sung Park (right)
2016.12.16
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Professor Ih Reappointed as Vice President of the ICA
Professor Jeong-Guon Ih of the Mechanical Engineering Department at KAIST has been re-elected as the Vice President of the International Commission for Acoustics (ICA). His second term of office is from October 16, 2016 to September 30, 2019. Professor Ih, the first Korean who was selected to a senior position on the ICA management board, took over his current post in 2015 when the vice president at the time passed away in the middle of his term. During his stint, Professor Ih played a key role in planning the ICA’s triennial gathering, the International Congress on Acoustics, in Gyeongju, Korea, scheduled for October 24-28, 2022. He will also serve as the general chair for the conference. The International Congress on Acoustics is the largest professional meeting in the field of acoustics. It provides a venue to meet, discuss, and exchange ideas covering all aspects of acoustics including an extensive technical exhibition that highlights the latest advances in acoustical products such as materials, systems, and equipment. Acoustics has grown to become an important element in the Information Age in the areas of automation, machine learning, and virtual reality. Hosting the Congress will support Korea’s goal to lead acoustic research and development on the global stage. Professor Ih said, “Serving international academic organizations offers great opportunities to learn global trends and to collaborate with various research institutions, universities, and industries worldwide. I hope my service will inspire many young Korean researchers to pursue their careers in this field.” Professor Ih is also a member of eight eminent international academic societies such as the Audio Engineering Society, the International Congress on Ultrasonics, and the International Institute of Noise Control Engineering. The ICA was founded in 1951 as a subcommittee of the International Union of Pure and Applied Physics (IUPAP), and it consists of 46 member states and four observer nations. It promotes international development and collaboration in all fields of acoustics including research, development, education, and standardization.
2016.12.16
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A KAIST Team Wins the Chem-E-Car Competition 2016
A KAIST team consisted of four students from the Department of Chemical and Biomolecular Engineering won the Chem-E-Car Competition 2016, which took place on November 13 at the Union Square in San Francisco. The students who participated were Young-Hyun Cha, Jin-Sol Shin, Dae-Seok Oh, and Wan-Tae Kim. Their adviser was Professor Doh Chang Lee of the same department. Established in 1999, the Chem-E-Car is an annual worldwide college competition for students majoring in chemical engineering. The American Institute of Chemical Engineers (AIChE), founded in 1908, is the world’s leading organization for chemical engineering professionals with more than 50,000 members from over 100 countries and hosts this competition every year. A total of 41 university teams including Carnegie Mellon University and Purdue University participated in this year’s competition. KAIST students competed in the event for the first time in 2014 and reached the rank of 28. In 2015, the students placed 16th, and finally, took the first place in last month’s competition, followed by the Georgia Institute of Technology. In the competition, students must design small-scale (20x30x40 cm) automobiles that operate chemically, as well as describe their research and drive their car a fixed distance down a wedge-shaped course to demonstrate the car’s capabilities. In addition to driving a specified distance (15-30 meters), the car must hold a payload of 0-500 mL of water. The organizers tell participants the exact distance and amount of payloads one hour before the competition begins. Winners are chosen based on their finishing time and how close their car reaches the finish line. Thus, students must show sophisticated coordination of chemical reactions to win. The KAIST team designed their car to have a stable power output using a Vanadium redox flow battery developed by Professor Hee Tak Kim of Chemical and Biomolecular Engineering. They employed iodine clock reactions to induce quick and precise chemical reactions to control their car. KAIST’s car finished with the best run coming within 11 cm of the target line; Georgia Tech’s car reached the finish line by 13 cm and New Jersey Institute of Technology’s car by 14 cm. Young-Hyun Cha, one of the four students, said, “When we first designed our car, we had to deal with many issues such as stalls or connection errors. We kept working on fixing these problems through trial and error, which eventually led us to success.” For a news article on KAIST’s win at 2016 Chemi-E-Car Competition by AIChE, see the link below: http://www.aiche.org/chenected/2016/11/koreas-kaist-wins-1st-place-2016-chem-e-car-competition-photos
2016.12.08
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Mobile Software Platform Research Center Recognized by the MSIP
The Mobile Software Platform Research Center (MSPRC) at KAIST received an award from the Minister of Science, ICT and Future Planning of Korea on November 29, 2016, at Coex in Seoul. The award was presented at the Conference of Software R&D Annual Report 2016 hosted by the Ministry of Science, ICT and Future Planning (MISP) and the Institute for Information and Communications Technology Promotion (IITP). The research center developed user experience (UX)-oriented mobile software platforms that support the invention of next-generation UX service technologies. The center has filed 37 patents and registered 15 technologies. Its researchers received ten Best Paper Awards and published a total of 133 papers in Korean and international journals. Research teams at MSPRC expect that their software platforms will offer training programs for software engineers and new UX services. They also said that their extensive event processing platforms would reduce energy consumption on mobile devices. Professor Seungryoul Maeng of the School of Computing, the Director of MSPRC, said, “This is a great honor for us. I am greatly thankful for the teamwork of participating departments--Computer Science, Industrial Design, and Industrial and Systems Engineering. We will continue to introduce our research outcomes and to work towards commercializing these results.” Members of the Mobile Software Platform Research Center, KAIST
2016.12.07
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Professor Kwon to Represent the Asia-Pacific Region of the IEEE RAS
Professor Dong-Soon Kwon of the Mechanical Engineering Department at KAIST has been reappointed to the Administrative Committee of the Institute of Electrical and Electronics Engineers (IEEE) Robotics and Automation Society (IEEE RAS). Beginning January 1, 2017, he will serve his second three-year term, which will end in 2019. In 2014, he was the first Korean appointed to the committee, representing the Asia-Pacific community of the IEEE Society. Professor Kwon said, “I feel thankful but, at the same time, it is a great responsibility to serve the Asian research community within the Society. I hope I can contribute to the development of robotics engineering in the region and in Korea as well.” Consisted of 18 elected members, the administrative committee manages the major activities of IEEE RAS including hosting its annual flagship meeting, the International Conference on Robotics and Automation. The IEEE RAS fosters the advancement in the theory and practice of robotics and automation engineering and facilitates the exchange of scientific and technological knowledge that supports the maintenance of high professional standards among its members.
2016.12.06
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Mystery of Biological Plastic Synthesis Machinery Unveiled
Plastics and other polymers are used every day. These polymers are mostly made from fossil resources by refining petrochemicals. On the other hand, many microorganisms naturally synthesize polyesters known as polyhydroxyalkanoates (PHAs) as distinct granules inside cells. PHAs are a family of microbial polyesters that have attracted much attention as biodegradable and biocompatible plastics and elastomers that can substitute petrochemical counterparts. There have been numerous papers and patents on gene cloning and metabolic engineering of PHA biosynthetic machineries, biochemical studies, and production of PHAs; simple Google search with “polyhydroxyalkanoates” yielded returns of 223,000 document pages. PHAs have always been considered amazing examples of biological polymer synthesis. It is astounding to see PHAs of 500 kDa to sometimes as high as 10,000 kDa can be synthesized in vivo by PHA synthase, the key polymerizing enzyme in PHA biosynthesis. They have attracted great interest in determining the crystal structure of PHA synthase over the last 30 years, but unfortunately without success. Thus, the characteristics and molecular mechanisms of PHA synthase were under a dark veil. In two papers published back-to-back in Biotechnology Journal online on November 30, 2016, a Korean research team led by Professor Kyung-Jin Kim at Kyungpook National University and Distinguished Professor Sang Yup Lee at the Korea Advanced Institute of Science and Technology (KAIST) described the crystal structure of PHA synthase from Ralstonia eutropha, the best studied bacterium for PHA production, and reported the structural basis for the detailed molecular mechanisms of PHA biosynthesis. The crystal structure has been deposited to Protein Data Bank in February 2016. After deciphering the crystal structure of the catalytic domain of PHA synthase, in addition to other structural studies on whole enzyme and related proteins, the research team also performed experiments to elucidate the mechanisms of the enzyme reaction, validating detailed structures, enzyme engineering, and also N-terminal domain studies among others. Through several biochemical studies based on crystal structure, the authors show that PHA synthase exists as a dimer and is divided into two distinct domains, the N-terminal domain (RePhaC1ND) and the C-terminal domain (RePhaC1CD). The RePhaC1CD catalyzes the polymerization reaction via a non-processive ping-pong mechanism using a Cys-His-Asp catalytic triad. The two catalytic sites of the RePhaC1CD dimer are positioned 33.4 Å apart, suggesting that the polymerization reaction occurs independently at each site. This study also presents the structure-based mechanisms for substrate specificities of various PHA synthases from different classes. Professor Sang Yup Lee, who has worked on this topic for more than 20 years, said, “The results and information presented in these two papers have long been awaited not only in the PHA community, but also metabolic engineering, bacteriology/microbiology, and in general biological sciences communities. The structural information on PHA synthase together with the recently deciphered reaction mechanisms will be valuable for understanding the detailed mechanisms of biosynthesizing this important energy/redox storage material, and also for the rational engineering of PHA synthases to produce designer bioplastics from various monomers more efficiently.” Indeed, these two papers published in Biotechnology Journal finally reveal the 30-year mystery of machinery of biological polyester synthesis, and will serve as the essential compass in creating designer and more efficient bioplastic machineries. References: Jieun Kim, Yeo-Jin Kim, So Young Choi, Sang Yup Lee and Kyung-Jin Kim. “Crystal structure of Ralstonia eutropha polyhydroxyalkanoate synthase C-terminal domain and reaction mechanisms” Biotechnology Journal DOI: 10.1002/biot.201600648 http://onlinelibrary.wiley.com/doi/10.1002/biot.201600648/abstract Yeo-Jin Kim, So Young Choi, Jieun Kim, Kyeong Sik Jin, Sang Yup Lee and Kyung-Jin Kim. “Structure and function of the N-terminal domain of Ralstonia eutropha polyhydroxyalkanoate synthase, and the proposed structure and mechanisms of the whole enzyme” Biotechnology Journal DOI: 10.1002/biot.201600649 http://onlinelibrary.wiley.com/doi/10.1002/biot.201600649/abstract
2016.12.02
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Aerospace Engineering Students Win the Minister's Award
On November 11, 2016, students from KAIST’s Aerospace Engineering Department won the Minister’s Award of Trade, Industry and Energy of Korea at the 14th Research Paper Competition hosted by Korea Aerospace Industries (KAI). The award came with a cash prize of USD 1,200 as well as opportunities to visit international airshows held abroad. The KAIST students' paper introduced a novel design concept for "a virtual-fighter-pilot system for unmanned combat aerial vehicles to enable them to engage in mass aerial combat." This was one of the two highest honors given to contestants. A group of students from Korea Aerospace University received the other grand prize from the Minister of Land, Infrastructure and Transport of Korea. The KAIST team consisted of two doctoral students, Hee-Min Shin and Jae-Hyun Lee, and one Master’s student, Hyun-Gi Kim. Their advisor, Professor “David” Hyunchul Shim, received the Special Achievement Award for his contribution to the paper. KAI’s competition was established in 2003 to spur academic interest and research in aerospace engineering. Over the past 14 years, contestants have submitted 376 papers, and KAI has published 88 papers. KAI has positioned itself as the host of one of the most prestigious research paper competitions held in Korea in the area of aerospace engineering. The Korean Society for Aeronautical and Space Sciences, the Korea Aerospace Industries Association, and the Korea Civil Aviation Development Association also sponsored the competition, with the Ministries of Trade, Industry and Energy and of Land, Infrastructure and Transport. Professor Shim said, “This represents a great honor for our students. In recent years, research in unmanned aerial systems has increased tremendously throughout the world, and I hope KAIST will continue to inspire and innovate research in this field.” Pictured from left to right are Hee-Min Shin, Jae-Hyun Lee, and Hyun-Gi Kim. Pictured from right to left are Professor Hyunchul Shim, Hyun-Gi Kim, Hee-Min Shin, and Vice President Sung-Sup Chang of Korea Aerospace Industries.
2016.11.22
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KAIST's Doctoral Student Receives a Hoffman Scholarship Award
Hyo-Sun Lee, a doctoral student at the Graduate School of EEWS (Environment, Energy, Water and Sustainability), KAIST, is a recipient of the 2016 Dorothy M. and Earl S. Hoffman Scholarships presented by the American Vacuum Society (AVS). The award ceremony took place during the Society’s 63rd International Symposium and Exhibition on November 6-11, 2016 in Nashville, Tennessee. Lee is the first Korean and foreign student to receive this scholarship. The Hoffman Scholarships were established in 2002 to recognize and encourage excellence in graduate studies in the sciences and technologies of interest to AVS. The scholarships are funded by a bequest from Dorothy M. Hoffman, who was a pioneering member of the Society of Women Engineers and served as the president of AVS in 1974. Lee received the scholarship for her research that detects hot electrons from chemical reactions on catalytic surface using nanodevices. Nano Letters, an academic journal published by the American Chemical Society, described her work in its February 2016 issue as a technology that allows quantitative analysis of hot electrons by employing a new nanodevice and therefore helps researchers understand better the mechanism of chemical reactions on nanocatalytic surface. She also published her work to detect the flow of hot electrons that occur on metal nanocatalytic surface during hydrogen oxidation reactions in Angewandte Chemie. Lee said, “I am pleased to receive this honor from such a world-renowned academic society. Certainly, this will be a great support for my future study and research.” Founded in 1953, AVS is an interdisciplinary, professional society composed of approximately 4,500 members worldwide. It supports networking among academic, industrial, government, and consulting professionals involved in a range of established and emerging science and technology areas such as chemistry, physics, engineering, business, and technology development.
2016.11.17
View 6943
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