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New drug targeting method for microbial pathogens developed using in silico cell
A ripple effect is expected on the new antibacterial discovery using “in silico” cells
Featured as a journal cover paper of Molecular BioSystems
A research team of Distinguished Professor Sang Yup Lee at KAIST recently constructed an in silico cell of a microbial pathogen that is resistant to antibiotics and developed a new drug targeting method that could effectively disrupt the pathogen"s growth using the in silico cell.
Hyun Uk Kim, a graduate research assistant at the Department of Chemical and Biomolecular Engineering, KAIST, conducted this study as a part of his thesis research, and the study was featured as a journal cover paper in the February issue of Molecular BioSystems this year, published by The Royal Society of Chemistry based in Europe.
It was relatively easy to treat infectious microbes using antibiotics in the past. However, the overdose of antibiotics has caused pathogens to increase their resistance to various antibiotics, and it has become more difficult to cure infectious diseases these days.
A representative microbial pathogen is Acinetobacter baumannaii. Originally isolated from soils and water, this microorganism did not have resistance to antibiotics, and hence it was easy to eradicate them if infected. However, within a decade, this miroorganism has transformed into a dreadful super-bacterium resistant to antibiotics and caused many casualties among the U.S. and French soldiers who were injured from the recent Iraqi war and infected with Acinetobacter baumannaii.
Professor Lee’s group constructed an in silico cell of this A. baumannii by computationally collecting, integrating, and analyzing the biological information of the bacterium, scattered over various databases and literatures, in order to study this organism"s genomic features and system-wide metabolic characteristics. Furthermore, they employed this in silico cell for integrative approaches, including several network analysis and analysis of essential reactions and metabolites, to predict drug targets that effectively disrupt the pathogen"s growth. Final drug targets are the ones that selectively kill pathogens without harming human body.
Here, essential reactions refer to enzymatic reactions required for normal metabolic functioning in organisms, while essential metabolites indicate chemical compounds required in the metabolism for proper functioning, and their removal brings about the effect of simultaneously disrupting their associated enzymes that interact with them.
This study attempted to predict highly reliable drug targets by systematically scanning biological components, including metabolic genes, enzymatic reactions, that constitute an in silico cell in a short period of time.
This research achievement is highly regarded as it, for the first time, systematically scanned essential metabolites for the effective drug targets using the concept of systems biology, and paved the way for a new antibacterial discovery. This study is also expected to contribute to elucidating the infectious mechanism caused by pathogens.
"Although tons of genomic information is poured in at this moment, application research that efficiently converts this preliminary information into actually useful information is still lagged behind. In this regard, this study is meaningful in that medically useful information is generated from the genomic information of Acinetobacter baumannii," says Professor Lee. "In particular, development of this organism"s in silico cell allows generation of new knowledge regarding essential genes and enzymatic reactions under specific conditions," he added.
This study was supported by the Korean Systems Biology Project of the Ministry of Education, Science and Technology, and the patent for the development of in silico cells of microbial pathogens and drug targeting methods has been filed.
[Picture 1 Cells in silico]
[Picture 2 A process of generating drug targets without harming human body while effectively disrupting the growth of a pathogen, after predicting metabolites from in silico cells]
2010.04.05 View 18512 -
New Text Book on Chemistry Published by KAIST Professor and Student
A chemistry textbook written in English and Korean will aid Korean students to learn General Chemistry in a global academic setting.
Korean students majoring in chemistry and looking for an opportunity to study abroad will have a new, handy textbook that presents them with a practical introduction to an English speaking lecture on general chemistry.
Aiming for advanced Korean high school and college/university students, the inter-language textbook is written by two incumbent professors teaching chemistry at a university in Korea and the US. The book will help Korean students prepare for a classroom where various topics of general chemistry are presented and discussed in English. Clear, collated sections of English and Korean text provide the student with sufficient explanation of the rudimentary topics and concepts.
Composed of 15 chapters on the core subjects of General Chemistry, i.e., Stoichiometry and Chemical Reactions, Thermochemistry, Atomic Structure, and Bonding, the textbook includes essential English vocabulary and usage sections for each chapter; it also contains a pre-reading study guide on the subject that prepares the student for listening to a lecture. This section includes view-graph type slides, audio files, and follow-up questions the student can use to prepare for an English-speaking course. The various accompanying audio files are prepared to expose the student to English scientific dialogue and serve as examples for instruction at Korean secondary and tertiary schools.
The book was coauthored by Korean and American scientists: A father and son, who have taught chemistry at an American and Korean university, wrote the book. Professor Melvyn R. Churchill at the State University of New York at Buffalo and Professor David G. Churchill at KAIST prepared all of the technical English text which was adapted from General Chemistry course lecture notes; the text was further shaped by original perspectives arising from many student interactions and questions.
This English text was translated into Korean by Professor Kwanhee Lee from the Department of Life and Food Science at Handong Global University, who coauthored a previous preparatory book for Korean students in a different subject. He also supplied an important introductory section which serves as a general guide to the classroom student. Kibong Kim, a doctoral student in the Department of Chemistry at KAIST, helped in preparing the book as well.
“This has been definitely a collaborative undertaking with an international academic crew and it underscores that the Korean internationalization in science is mainstream. Professors and a Korean student created a new book for Korean consumption and benefit,” Professor David G. Churchill says.
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Bibliography: “How to Prepare for General Chemistry Taught in English” by David George Churchill, Melvyn Rowen Churchill, Kwanhee Lee & Kibong Kim, Darakwon Publishing, Paju, Republic of Korea, 2010, 400 pp, ISBN 978-89-5995-730-9 (1 Audio CD included)
2010.04.02 View 16232
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KAIST Commencement 2010 was held on February 26, 2010.
A total of 2,205 are the newly conferred degree holders: 479 for Ph.D., 988 for Master’s, and 738 for B.S. degrees. Since its foundation in 1971, KAIST has so far produced 38,882 graduates.
KAIST held the 2010 graduation ceremony on February 26, 2010 at its newly built place, called “Sports Complex Building.” Approximately 2,500 guests including Minister Byung-Man Ahn, Education, Science and Technology Ministry; Chairman Mun-Sul Jeong, KAIST Board of Trustees; representatives from the KAIST alumni; graduating students; and faculty joined the ceremony to celebrate the commencement.
Honorary Doctorates
At the ceremony, KAIST has conferred four honorary doctorate degrees in recognition of recipients’ contribution to the advancement of science and technology and development of science and engineering education in Korea and the world. The recipients were Arden L. Bement Jr., Director of US National Science Foundation; Lars Pallesen, President of Technical University of Denmark; Donald C.W. Kim, Chairman of AMKOR A&E, Inc.; and Beang-Ho Kim, Chairman of Seojeon Farm.
Graduation Honors: President’s List
Dong-Han Kim, majoring in Mathematical Sciences, College of Natural Science, was nominated as President’s List. He received an award for an outstanding academic achievement from the Minister of Education, Science and Technology and gave a gradation speech on behalf of the graduating class.
Birthplace of Promising Young Scientists in Korea
KAIST has earned a reputation for training the next generation of young scientists in Korea, and its 2010 Commencement has confirmed such fame. Among 479 Ph.D. degree holders, 151 (31%) students are in their 20s. The youngest who has received a doctoral degree is Jin-Ah Lee, graduating from College of Life Science and Bioengineering.
Commencing International Students
Among international students graduating this year, two students from India received their doctoral degrees in Biological Sciences: Kataru Raghu Prasad and Chaya Mohan. They are a married couple and now both postdoctoral researchers, working at KAIST labs. Wearing academic regalia and standing together to take a picture, the couple said, “We would definitely recommend KAIST to prospective international students because it offers the best education and research facilities comparable to those of any leading universities in the world. With the knowledge and experience acquired from studying at KAIST, we hope to contribute to the development of our country in the future.”
2010.03.04 View 16208
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[Event Notice] International Workshop on Computer Science Education and Research
2010 Asia-Africa International Workshop on Computer Science Education and Research
The Department of Computer Science at KAIST will host an international workshop on the education and research of computer science in Asia and Africa. The workshop, “2010 Asia-Africa International Workshop on Computer Science Education and Research” will be held on February 17-19, 2010 at a conference room located inside the KAIST Main Building. Deans of computer science departments from 13 different universities in Asia and Africa will attend the workshop.
At the workshop, participants will introduce their own education and research programs and discuss ways to have mutual collaborations. This is the first time for representatives from the computer science and engineering departments of leading universities in the newly developing countries—for instance, Thailand, Vietnam, Nigeria, Egypt, and Indonesia—to attend a meeting organized by institutions based in Korea. These countries have a large amount of natural resources and great potential to grow as a front runner in the information technology (IT) sector.
Professor Key-Sun Choi, Dean of Computer Science Department at KAIST, hopes that the workshop will be a place where participated universities discuss mutual cooperation and collaboration; exchange their ideas and knowledge of course management and education and research experiences; and share their vision of global leadership to advance the development of computer science and engineering.
Dean Choi mentioned that his department has also had consultations with the Korean government regarding a possible exchange program to select 10 or 20 members of faculty and students from universities in the newly developing nations for a doctoral course at KAIST. The exchange program, he said, would attract many of excellent candidates from nations with an emerging market for the IT industry to study at KAIST. The highly trained workforces who finish the KAIST doctoral program will contribute not only to their nations’ IT development but also to Korea’s.
2010.02.18 View 15286
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Master of Science in Intellectual Property: First Class Starts on Saturday, February 6, 2010
Newly Established, Postgraduate Course for Master of Science in Intellectual Property
First class starts on February 6th, 2010
In conjunction with Korean Intellectual Property Office (KIPO), KAIST has established a new postgraduate course for a master of science in intellectual property (IP). 41 students have enrolled the course, and its first class will begin February 6th, 2010. With a diverse professional background, the first-year students came from private businesses, IP service industry, and public organizations.
Globally well-known companies—Samsung Electronics, LG Electronics, and the Pohang Iron and Steel Company (POSCO)—and mid-sized companies have offered scholarships to support the new M.S. Program. Business and industry in Korea have recognized the increasingly important role of intellectual property in a modern economy and showed a strong interest in developing workforce specialized in subjects such as, but not limited to, patent law, copyright and designs law, trade mark law, unfair competition, anti-trust law, competition law, and trade secret law.
Prosecutor Chan-Gi Na from Seoul Central District Prosecutor’s Office said, “I’ve applied for the master program at KAIST because I wanted to learn more about intellectual property in greater depth. Through the coursework, I hope to enhance my knowledge on the subjects and use it for the protection of Koreans’ IP related rights and the development of our nation’s IP industry.”
Assistant Manager Jin-Hong Bae from Samsung Securities, Inc. said, “Since the capital market law becomes effective, the need for developing new financial products or services in our finance market has rapidly grown. We no longer can make our financial products by simply copying or ripping off ideas from others. It’s a must practice, not an option, to set up a system under which we are able to protect our IPs.”
“I would like to become an expert in our finance market, who really knows how to commercialize intellectual property assets into benefits, so any know-hows or ideas accumulated from years of working in the field can be registered and protected,” added Mr. Bae.
KAIST’s Mater Program for intellectual property is designed for engineers who wish to acquire the skills required to play a leading role in the field. These engineers, KAIST anticipates, will establish and execute business strategies to protect intellectual property, generate added values for a company, and effectively respond against patent related claims.
The intellectual property will seize up to 90% of business values to be generated in the 21st century. KAIST has long foreseen the need for training top-notch engineers in intellectual property. Combined with multidisciplinary approach to engineering, law, and management, the new M.S. Program will provide students with a variety form of classes to assist them in getting a practical knowledge as needed based on their interests and career aspirations. Examples of the classes are workshops on the change in technology trends—i.e., information technology (IT), environmental technology (ET), and bio technology (BT); standardization of intellectual property and value assessment; and patent law related claims.
“All professors involved in the course are experts who are equipped with hands-on experiences in working on intellectual property for a long time at government agencies, companies, and law firms,” Professor Chul-Ho Kim, responsible for overseeing the entire program, said.
He also expressed his confidence that “We have set up an academic system to induct highly qualified professionals and engineers, capable of handling all aspects of intellectual property related issues, into work places. Our coursework encompasses technology, research and development (R&D), and management, and students who complete the program will be ready to tackle down any intellectual property matters in the 21st century.”
Freshmen convocation for the IP M.S. Program is scheduled on February 20th at KAIST, and President Nam Pyo Suh and Commissioner Jung-Sik Koh of Korean Intellectual Property (KIPO) will attend the event.
2010.02.04 View 15028
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President Nam Pyo Suh of KAIST discussed cooperation with KUSTAR on the training of skilled manpower for research and development (R&D)
Representatives from Korea Advanced Institute of Science and Technology (KAIST), Khalifa University of Science, Technology and Research (KUSTAR), Emirate Nuclear Energy Corporation (ENEC), and the Institute of Applied Technology (IAT) had a meeting on mutual cooperation at the Intercontinental Hotel in Abu Dhabi, the United Arab Emirates (UAE), on January 14, 2009.
Participants of the meeting were President Nam Pyo Suh of KAIST, President Arif Sultan Al Hammadi of KUSTAR, President Mohamed Al Hammadi of ENEC, and Director General Abdullatif Mohamed Al Shamsi of IAT.
A press conference on the training of skilled manpower for research and development (R&D) in the UAE followed afterwards.
At the end of December in 2009, a Korean consortium led by Korea Electric Power Corporation (KEPCO) beat bids from its competitors to construct four nuclear power plants in the UAE. Representing the consortium, Minister Kyung Hwan Choi of Knowledge Economy Ministry signed a comprehensive agreement with KUSTAR and the Institute of Applied Technology (IAT) for the delivery of nuclear power plants.
On his visit, President Suh discussed with KUSTAR the agreement above in greater detail on subjects, where KAIST renders its cooperation, such as research collaboration, university degree program, and training to produce qualified personnel necessary for the development of UAE’s nuclear energy industry.
On research collaboration, sharing its expertise and knowledge accumulated years from the operation of academic and research programs, KAIST agreed to provide cooperation to KUSTAR in developing the latter as a leading science, technology, and research university in ten years through mutual activities such as research collaborations, recruitment and exchange of outstanding researchers and graduate students, expansion of research facilities, and creation of major research policies. Furthermore, in support of nuclear energy program in the UAE, KAIST agreed to develop a joint research program in nuclear engineering and exchange faculty members and students for research collaboration.
On a university degree program, KAIST agreed for mutual cooperation to launch academic programs at KUSTAR, covering BSc, MSc, and PhD degrees to specialize in areas such as mechanical engineering, electrical engineering, nuclear engineering, biomedical engineering, nano technology, science, and information technology. To that end, KAIST will dispatch its faculty to KUSTAR; provide assistance in developing curriculum and teaching materials; and exchange students for research collaboration.
President Arif of KUSTAR mentioned that the university will cooperate with the relevant institutions in Korea, i.e., Korea Development Institute (KDI) and the Korea Institute of Nuclear Safety (KINS), to train skilled workers required for the development of nuclear energy program in the UAE.
He also added, “These cooperative programs will introduce more educational opportunities to our students, and as a result, they can make greater contributions to the development of our nation’s future technologies in various areas. Our students will have a chance to study a broad range of academic subjects through partnership made with the Republic of Korea, and I expect to see improvements in our engineering programs by integrating KAIST’s state-of-the-art academic courses into our system.”
President Arif expressed his hope “to increase cooperation beyond the agreement made between the two countries, like allowing more exchanges and interactions with KAIST for the development of science and technology in Korea and the UAE.”
“Establishing mutual cooperation between KAIST and KUSTAR is a historic event not only for our two universities but also for our two countries. The two universities will make a great contribution to the improvement of the future of humanity by working together to solve the most important, difficult issues faced in the 21st century,” said President Suh.
He also said that “all members of KAIST community will make our utmost efforts to advance the quality of education in two schools and to implement innovative researches through mutual cooperation.”
KUSTAR, a national university in the UAE, was founded on February 13, 2007 by a mandate of the current President Shaikh Khalifa Bin Zayed Al Nahyan to create a higher education institute.
KUSTAR has been building its permanent campus in Abu Dhabi, the capital of UAE since establishment and merged with the campus in Sharjah (formerly known as Etisalat University College with 18 years of history) in 2008. The University offers education and research programs in five disciplines of engineering, logistics and management, health science, homeland security, and applied science.
There are more or less 30 foreign accredited universities set up in the UAE from countries like the US, UK, Australia, France, Ireland, and Canada. Examples of such, among other things, are New York University Abu Dhabi campus and Middlesex University Dubai campus.
Many of the foreign universities in the UAE, however, have colleges of pharmacy, computer science, aviation, management information, fashion design, business management, and medical science including Harvard Medical School Dubai Center, but not many in science and research. Therefore, KAIST’s assistance in KUSTAR’s endeavor to become a leading science and research university in the UAE is timely. The current government of UAE anticipates, with a great interest, to see a leading science and research intuition built in their nation.
Attachment: Current Status of Universities in the UAE as of 2009
Background Information
The United Arab Emirates (UAE) is a federation of seven emirates (Abu Dhabi, Dubai, Sharjah, Ajman, Umm al-Quwain, Ras al-Khaimah, and Fujairah) situated on the Arabian Peninsula, which borders with Oman and Saudi Arabia.
The UAE has the world"s sixth largest oil reserves. As of 2008, its gross domestic product is $2,621,000.5 million and its nominal per capita gross domestic product is $5 5,028, becoming one of the most developed economies in the Middle East. The UAE’s total population as of the said year is 4,760.4 thousand, and its purchasing power per capita is 40th largest in the world. The UAE’s Human Development Index for Asian continent is relatively high, ranking 31st globally.
In 1985, the UAE launched its own airline, Emirates Airline, which has become one of the fastest growing airlines in the world. The Emirates Airline is a sponsor for Arsenal soccer club.
The Republic of Korea established full diplomatic relations with the UAE in June of 1980. On December 27, 2009, a Korean consortium led by Korea Electrical Power Corporation (KEPCO) signed a contract with the UAE to build nuclear power plants.
2010.01.15 View 18233 -
KAIST Wins Official Membership of ERCIS
The Center for Software Policy Study of KAIST has recently become the 20th official member of the European Research Center for Information Systems (ERCIS) by signing an agreement with the organization, university authorities said on Thursday (Oct. 22).
The ERCIS is a network of scientists who conduct cooperative research in the field of integrated information systems development and organizational design. The Center undertakes interdisciplinary research with the participation of computer scientists, business management experts and law scholars.
KAIST will seek to activate exchange of professors, research fellows and graduate students with ERCIS members, as well as implementing credit exchange and dual degree programs.
ERCIS, was first organized by the German state of North Rhine-Westfahlia, is currently managed by the University of Muenster, a global leader in the field of information systems and business administration. Joining the ERCIS are one university each from New Zealand, the Netherlands, Germany, Russia, Liechtenstein, the United States, Switzerland, Spain, Slovenia, Ireland, Britain, Austria, Italy, the Czech Republic, Poland, France, Finland and Australia.
KAIST"s Center for Software Policy Study is currently preparing for the establishment of a support system for developers of the mobile application software as part of the EUREKA project. Korea is playing a leading role in this project on the strength of its competitiveness in the mobile phone industry.
EUREKA is a pan-European intergovernmental network for market-oriented, industrial R&D aimed at enhancing European competitiveness through its support to businesses, research centers and universities who carry out pan-European projects to develop innovative products, processes and services.
2009.10.22 View 14687
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Prof. Cho Elected Editor-in-Chief of Systems Biology
Prof. Kwang-Hyun Cho of Department of Bio and Brain Engineering at KAIST has been recently elected editor-in-chief of the Systems Biology, an international journal published by the London-based Institution of Engineering and Technology (IET), the university authorities said on Wednesday (Sept. 23)
By the year 2012, Cho will oversee the editorial process of the journal covering intra- and inter-cellular dynamics, using systems- and signal-oriented approaches. IET, one of the world"s leading professional societies for the engineering and technology community, has a worldwide membership of more than 150,000.
Prof. Cho"s research interests cover the areas of systems science with bio-medical applications including systems biology and bio-inspired engineering based on molecular systems biology. He is currently an editorial board member of Systems and Synthetic Biology (Springer, Netherlands, from 2006), BMC Systems Biology (BMC, London, U.K., from 2007), Gene Regulation and Systems Biology (Libertas Academica, New Zealand, from 2007), and Bulletin of Mathematical Biology (Springer, New York, from 2008), and an editorial advisory board member of Molecular BioSystems (The Royal Society of Chemistry, U.K.).
2009.09.24 View 17873 -
Scaling Laws between Population and Facility Densities Found
A research team led by Prof. Ha-Woong Jeong of the Department of Physics, KAIST, has found a positive correlation between facilities and population densities, university authorities said on Tuesday (Sept. 2). The research was conducted in the cooperation with a research team of Prof. Beom-Jun Kim at Sungkyunkwan University.
The researchers investigated the ideal relation between the population and the facilities within the framework of an economic mechanism governing microdynamics.
In previous studies based on the global optimization of facility positions in minimizing the overall travel distance between people and facilities, the relation between population and facilities should follow a simple law. The new empirical analysis, however, determined that the law is not a fixed value but spreads in a broad range depending on facility types.
To explain this discrepancy, the researchers proposed a model based on economic mechanism that mimics the competitive balance between the profit of the facilities and the social opportunity cost for population.
The results were published in the Proceedings of the National Academy of Sciences of the United States on Aug. 25.
2009.09.04 View 14658
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KAIST Undergraduates Open Four-Day International Conference
The ICISTS-KAIST, an annual international conference organized by KAIST undergraduate students, opened on Thursday (Aug. 20) at the KAIST"s main campus in Daejeon.
The 2009 ICISTS (International Conference for the Integration of Science and Technology into Society) drew around 200 experts and students from 44 countries. Since its inception in 2005 to promote discourse on important science and technology issues affecting modern society, the conference has served as an opportunity for academic networking among students in various parts of the world.
The four-day conference consists of lectures, open discussions among lecturers and students, field trips to help students to understand actual applications, and team projects.
This year"s conference offers three workshops under the themes of "Climate Change: Merging Technology and Policy for Green Solutions"; "Human-Computer Interaction: Designing Computer System for Intuitive Human Access"; and "Nano Clinic: Breakthrough in Conquering Disease."
Lectures by invited experts in various scientific fields will help broaden students" perspectives particularly from interdisciplinary viewpoints, said an organizer of the conference.
2009.08.28 View 16831
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KAIST College of Life Sciences and Bioengineering Signs MOU with Harvard
KAIST’s College of Life Sciences and Bioengineering recently signed a memorandum of understanding (MOU) with Harvard University’s Center for Brain Science on July 20, which will allow for joint research and exchange in researchers between the two institutions.
Headed by Director Kenneth Blum, Harvard’s Center for Brain Science leads the world in brain-related research. The new MOU will allow for research cooperation, exchanges of professors, researchers, and students, joint usage of infrastructure and research materials, and finally, sharing of research assignments.
The Dean of the College of Life Sciences and Bioengineering Sang Yup Lee, who concerted efforts to form the MOU said, “This agreement will bring together two of the world’s leading brain-related research teams, and I hope that combining their expertise will bring great advances in brain science and engineering.
KAIST’s College of Life Science and Bioengineering, which is known for its creative interdisciplinary research, is producing exemplary research results in the field of brain science from its Biological Sciences and Bio and Brain Engineering departments.
In addition to cooperation with Harvard, KAIST has also formed partnerships with Emory University, Japan’s RIKEN Brain Institute, and Germany’s Max Planck Institute. Not only does it have a worldwide network pertaining to brain research, but KAIST has also engaged in cooperative research with prominent domestic institutions such as, Asan Medical Center, the Korea Research Institute of Bioscience and Biotechnology, the Korea Research Institute of Standards and Science, and the SK Corporation. Through these connections, KAIST has managed to lead in mutually cooperative brain interdisciplinary research.
2009.08.10 View 18223
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Prof. Choi Unveils Method to Improve Emission Efficiency of OLED
A KAIST research team led by Prof. Kyung-Cheol Choi of the School of Electrical Engineering & Computer Science discovered the surface plasmon-enhanced spontaneous emission based on an organic light-emitting device (OLED), a finding expected to improve OLED"s emission efficiency, KAIST authorities said on Thursday (July 9).
For surface plasmon localization, silver nanoparticles were thermally deposited in a high vacuum on cathode. Since plasmons provide a strong oscillator decay channel, time-resolved photoluninescene (PL) results displayed a 1.75-fold increased emission rate, and continuous wave PL results showed a twofold enhanced intensity.
"The method using surface plasmon represents a new technology to enhance the emission efficiency of OLED. It is expected to greatly contribute to the development of new technologies in OLED and flexible display, as well as securing original technology," Prof. Choi said.
The finding was published in the April issue of Applied Physics Letters and the June 25 issue of Optics Express. It will be also featured as the research highlight of the August issue of Nature Photonics and Virtual Journal of Ultrafast Science.
2009.07.09 View 22115