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KAIST Enables On-Site Disease Diagnosis in Just 3 Minutes... Nanozyme Reaction Selectivity Improved 38-Fold
<(From Left) Professor Jinwoo Lee, Ph.D candidate Seonhye Park and Ph.D candidate Daeeun Choi from Chemical & Biomolecular Engineering>
To enable early diagnosis of acute illnesses and effective management of chronic conditions, point-of-care testing (POCT) technology—diagnostics conducted near the patient—is drawing global attention. The key to POCT lies in enzymes that recognize and react precisely with specific substances. However, traditional natural enzymes are expensive and unstable, and nanozymes (enzyme-mimicking catalysts) have suffered from low reaction selectivity. Now, a Korean research team has developed a high-sensitivity sensor platform that achieves 38 times higher selectivity than existing nanozymes and allows disease diagnostics visible to the naked eye within just 3 minutes.
On the 28th, KAIST (President Kwang Hyung Lee) announced that Professor Jinwoo Lee’s research team from the Department of Chemical & Biomolecular Engineering, in collaboration with teams led by Professor Jeong Woo Han at Seoul National University and Professor Moon Il Kim at Gachon University, has developed a new single-atom catalyst that selectively performs only peroxidase-like reactions while maintaining high reaction efficiency.
Using bodily fluids such as blood, urine, or saliva, this diagnostic platform enables test results to be read within minutes even outside hospital settings—greatly improving medical accessibility and ensuring timely treatment. The key lies in the visual detection of biomarkers (disease indicators) through color changes triggered by enzyme reactions. However, natural enzymes are expensive and easily degraded in diagnostic environments, limiting their storage and distribution.
To address this, inorganic nanozyme materials have been developed as substitutes. Yet, they typically lack selectivity—when hydrogen peroxide is used as a substrate, the same catalyst triggers both peroxidase-like reactions (which cause color change) and catalase-like reactions (which remove the substrate), reducing diagnostic signal accuracy.
To control catalyst selectivity at the atomic level, the researchers used an innovative structural design: attaching chlorine (Cl) ligands in a three-dimensional configuration to the central ruthenium (Ru) atom to fine-tune its chemical properties. This enabled them to isolate only the desired diagnostic signal.
<Figure1. The catalyst in this study (ruthenium single-atom catalyst) exhibits peroxidase-like activity with selectivity akin to natural enzymes through three-dimensional directional ligand coordination. Due to the absence of competing catalase activity, selective peroxidase-like reactions proceed under biomimetic conditions. In contrast, conventional single-atom catalysts with active sites arranged on planar surfaces exhibit dual functionality depending on pH. Under neutral conditions, their catalase activity leads to hydrogen peroxide depletion, hindering accurate detection. The catalyst in this study eliminates such interference, enabling direct detection of biomarkers through coupled reactions with oxidases without the need for cumbersome steps like buffer replacement. The ability to simultaneously detect multiple target substances under biomimetic conditions demonstrates the practicality of ruthenium single-atom catalysts for on-site diagnostics>
Experimental results showed that the new catalyst achieved over 38-fold improvement in selectivity compared to existing nanozymes, with significantly increased sensitivity and speed in detecting hydrogen peroxide. Even in near-physiological conditions (pH 6.0), the catalyst maintained its performance, proving its applicability in real-world diagnostics.
By incorporating the catalyst and oxidase into a paper-based sensor, the team created a system that could simultaneously detect four key biomarkers related to health: glucose, lactate, cholesterol, and choline—all with a simple color change.
This platform is broadly applicable across various disease diagnostics and can deliver results within 3 minutes without complex instruments or pH adjustments. The findings show that diagnostic performance can be dramatically improved without changing the platform itself, but rather by engineering the catalyst structure.
<Figure 2.(a) Schematic diagram of the paper sensor (Zone 1: glucose oxidase immobilized; Zone 2: lactate oxidase immobilized; Zone 3: choline oxidase immobilized; Zone 4: cholesterol oxidase immobilized; Zone 5: no oxidase enzyme). (b) Single biomarker (single disease indicator) detection using the ruthenium single‑atom catalyst–based paper sensor.(c) Multiple biomarker (multiple disease indicator) detection using the ruthenium single‑atom catalyst–based paper sensor>
Professor Jinwoo Lee of KAIST commented, “This study is significant in that it simultaneously achieves enzyme-level selectivity and reactivity by structurally designing single-atom catalysts.” He added that “the structure–function-based catalyst design strategy can be extended to the development of various metal-based catalysts and other reaction domains where selectivity is critical.”
Seonhye Park and Daeeun Choi, both Ph.D. candidates at KAIST, are co-first authors. The research was published on July 6, 2025, in the prestigious journal Advanced Materials
-Title: Breaking the Selectivity Barrier of Single-Atom Nanozymes Through Out-of-Plane Ligand Coordinatio
- Authors: Seonhye Park (KAIST, co–first author), Daeeun Choi (KAIST, co–first author), Kyu In Shim (SNU, co–first author), Phuong Thy Nguyen (Gachon Univ., co–first author), Seongbeen Kim (KAIST), Seung Yeop Yi (KAIST), Moon Il Kim (Gachon Univ., corresponding author), Jeong Woo Han (SNU, corresponding author), Jinwoo Lee (KAIST, corresponding author
-DOI: https://doi.org/10.1002/adma.202506480
This research was supported by the Ministry of Science and ICT and the National Research Foundation of Korea (NRF).
2025.07.29 View 473 -
Vulnerability Found: One Packet Can Paralyze Smartphones
<(From left) Professor Yongdae Kim, PhD candidate Tuan Dinh Hoang, PhD candidate Taekkyung Oh from KAIST, Professor CheolJun Park from Kyung Hee University; and Professor Insu Yun from KAIST>
Smartphones must stay connected to mobile networks at all times to function properly. The core component that enables this constant connectivity is the communication modem (Baseband) inside the device. KAIST researchers, using their self-developed testing framework called 'LLFuzz (Lower Layer Fuzz),' have discovered security vulnerabilities in the lower layers of smartphone communication modems and demonstrated the necessity of standardizing 'mobile communication modem security testing.'
*Standardization: In mobile communication, conformance testing, which verifies normal operation in normal situations, has been standardized. However, standards for handling abnormal packets have not yet been established, hence the need for standardized security testing.
Professor Yongdae Kim's team from the School of Electrical Engineering at KAIST, in a joint research effort with Professor CheolJun Park's team from Kyung Hee University, announced on the 25th of July that they have discovered critical security vulnerabilities in the lower layers of smartphone communication modems. These vulnerabilities can incapacitate smartphone communication with just a single manipulated wireless packet (a data transmission unit in a network). In particular, these vulnerabilities are extremely severe as they can potentially lead to remote code execution (RCE)
The research team utilized their self-developed 'LLFuzz' analysis framework to analyze the lower layer state transitions and error handling logic of the modem to detect security vulnerabilities. LLFuzz was able to precisely extract vulnerabilities caused by implementation errors by comparing and analyzing 3GPP* standard-based state machines with actual device responses.
*3GPP: An international collaborative organization that creates global mobile communication standards.
The research team conducted experiments on 15 commercial smartphones from global manufacturers, including Apple, Samsung Electronics, Google, and Xiaomi, and discovered a total of 11 vulnerabilities. Among these, seven were assigned official CVE (Common Vulnerabilities and Exposures) numbers, and manufacturers applied security patches for these vulnerabilities. However, the remaining four have not yet been publicly disclosed.
While previous security research primarily focused on higher layers of mobile communication, such as NAS (Network Access Stratum) and RRC (Radio Resource Control), the research team concentrated on analyzing the error handling logic of mobile communication's lower layers, which manufacturers have often neglected.
These vulnerabilities occurred in the lower layers of the communication modem (RLC, MAC, PDCP, PHY*), and due to their structural characteristics where encryption or authentication is not applied, operational errors could be induced simply by injecting external signals.
*RLC, MAC, PDCP, PHY: Lower layers of LTE/5G communication, responsible for wireless resource allocation, error control, encryption, and physical layer transmission.
The research team released a demo video showing that when they injected a manipulated wireless packet (malformed MAC packet) into commercial smartphones via a Software-Defined Radio (SDR) device using packets generated on an experimental laptop, the smartphone's communication modem (Baseband) immediately crashed
※ Experiment video: https://drive.google.com/file/d/1NOwZdu_Hf4ScG7LkwgEkHLa_nSV4FPb_/view?usp=drive_link
The video shows data being normally transmitted at 23MB per second on the fast.com page, but immediately after the manipulated packet is injected, the transmission stops and the mobile communication signal disappears. This intuitively demonstrates that a single wireless packet can cripple a commercial device's communication modem.
The vulnerabilities were found in the 'modem chip,' a core component of smartphones responsible for calls, texts, and data communication, making it a very important component.
Qualcomm: Affects over 90 chipsets, including CVE-2025-21477, CVE-2024-23385.
MediaTek: Affects over 80 chipsets, including CVE-2024-20076, CVE-2024-20077, CVE-2025-20659.
Samsung: CVE-2025-26780 (targets the latest chipsets like Exynos 2400, 5400).
Apple: CVE-2024-27870 (shares the same vulnerability as Qualcomm CVE).
The problematic modem chips (communication components) are not only in premium smartphones but also in low-end smartphones, tablets, smartwatches, and IoT devices, leading to the widespread potential for user harm due to their broad diffusion.
Furthermore, the research team experimentally tested 5G vulnerabilities in the lower layers and found two vulnerabilities in just two weeks. Considering that 5G vulnerability checks have not been generally conducted, it is possible that many more vulnerabilities exist in the mobile communication lower layers of baseband chips.
Professor Yongdae Kim explained, "The lower layers of smartphone communication modems are not subject to encryption or authentication, creating a structural risk where devices can accept arbitrary signals from external sources." He added, "This research demonstrates the necessity of standardizing mobile communication modem security testing for smartphones and other IoT devices."
The research team is continuing additional analysis of the 5G lower layers using LLFuzz and is also developing tools for testing LTE and 5G upper layers. They are also pursuing collaborations for future tool disclosure. The team's stance is that "as technological complexity increases, systemic security inspection systems must evolve in parallel."
First author Tuan Dinh Hoang, a Ph.D. student in the School of Electrical Engineering, will present the research results in August at USENIX Security 2025, one of the world's most prestigious conferences in cybersecurity.
※ Paper Title: LLFuzz: An Over-the-Air Dynamic Testing Framework for Cellular Baseband Lower Layers (Tuan Dinh Hoang and Taekkyung Oh, KAIST; CheolJun Park, Kyung Hee Univ.; Insu Yun and Yongdae Kim, KAIST)
※ Usenix paper site: https://www.usenix.org/conference/usenixsecurity25/presentation/hoang (Not yet public), Lab homepage paper: https://syssec.kaist.ac.kr/pub/2025/LLFuzz_Tuan.pdf
※ Open-source repository: https://github.com/SysSec-KAIST/LLFuzz (To be released)
This research was conducted with support from the Institute of Information & Communications Technology Planning & Evaluation (IITP) funded by the Ministry of Science and ICT.
2025.07.25 View 679 -
Approaches to Human-Robot Interaction Using Biosignals
<(From left) Dr. Hwa-young Jeong, Professor Kyung-seo Park, Dr. Yoon-tae Jeong, Dr. Ji-hoon Seo, Professor Min-kyu Je, Professor Jung Kim >
A joint research team led by Professor Jung Kim of KAIST Department of Mechanical Engineering and Professor Min-kyu Je of the Department of Electrical and Electronic Engineering recently published a review paper on the latest trends and advancements in intuitive Human-Robot Interaction (HRI) using bio-potential and bio-impedance in the internationally renowned academic journal 'Nature Reviews Electrical Engineering'.
This review paper is the result of a collaborative effort by Dr. Kyung-seo Park (DGIST, co-first author), Dr. Hwa-young Jeong (EPFL, co-first author), Dr. Yoon-tae Jeong (IMEC), and Dr. Ji-hoon Seo (UCSD), all doctoral graduates from the two laboratories. Nature Reviews Electrical Engineering is a review specialized journal in the field of electrical, electronic, and artificial intelligence technology, newly launched by Nature Publishing Group last year. It is known to invite world-renowned scholars in the field through strict selection criteria. Professor Jung Kim's research team's paper, titled "Using bio-potential and bio-impedance for intuitive human-robot interaction," was published on July 18, 2025. (DOI: https://doi.org/10.1038/s44287-025-00191-5)
This review paper explains how biosignals can be used to quickly and accurately detect movement intentions and introduces advancements in movement prediction technology based on neural signals and muscle activity. It also focuses on the crucial role of integrated circuits (ICs) in maximizing low-noise performance and energy efficiency in biosignal sensing, covering thelatest development trends in low-noise, low-power designs for accurately measuring bio-potential and impedance signals.
The review emphasizes the importance of hybrid and multi-modal sensing approaches, presenting the possibility of building robust, intuitive, and scalable HRI systems. The research team stressed that collaboration between sensor and IC design fields is essential for the practical application of biosignal-based HRI systems and stated that interdisciplinary collaboration will play a significant role in the development of next-generation HRI technology. Dr. Hwa-young Jeong, a co-first author of the paper, presented the potential of bio-potential and impedance signals to make human-robot interaction more intuitive and efficient, predicting that it will make significant contributions to the development of HRI technologies such as rehabilitation robots and robotic prostheses using biosignals in the future. This research was supported by several research projects, including the Human Plus Project of the National Research Foundation of Korea.
2025.07.24 View 557 -
KAIST Successfully Implements 3D Brain-Mimicking Platform with 6x Higher Precision
<(From left) Dr. Dongjo Yoon, Professor Je-Kyun Park from the Department of Bio and Brain Engineering, (upper right) Professor Yoonkey Nam, Dr. Soo Jee Kim>
Existing three-dimensional (3D) neuronal culture technology has limitations in brain research due to the difficulty of precisely replicating the brain's complex multilayered structure and the lack of a platform that can simultaneously analyze both structure and function. A KAIST research team has successfully developed an integrated platform that can implement brain-like layered neuronal structures using 3D printing technology and precisely measure neuronal activity within them.
KAIST (President Kwang Hyung Lee) announced on the 16th of July that a joint research team led by Professors Je-Kyun Park and Yoonkey Nam from the Department of Bio and Brain Engineering has developed an integrated platform capable of fabricating high-resolution 3D multilayer neuronal networks using low-viscosity natural hydrogels with mechanical properties similar to brain tissue, and simultaneously analyzing their structural and functional connectivity.
Conventional bioprinting technology uses high-viscosity bioinks for structural stability, but this limits neuronal proliferation and neurite growth. Conversely, neural cell-friendly low-viscosity hydrogels are difficult to precisely pattern, leading to a fundamental trade-off between structural stability and biological function. The research team completed a sophisticated and stable brain-mimicking platform by combining three key technologies that enable the precise creation of brain structure with dilute gels, accurate alignment between layers, and simultaneous observation of neuronal activity.
The three core technologies are: ▲ 'Capillary Pinning Effect' technology, which enables the dilute gel (hydrogel) to adhere firmly to a stainless steel mesh (micromesh) to prevent it from flowing, thereby reproducing brain structures with six times greater precision (resolution of 500 μm or less) than conventional methods; ▲ the '3D Printing Aligner,' a cylindrical design that ensures the printed layers are precisely stacked without misalignment, guaranteeing the accurate assembly of multilayer structures and stable integration with microelectrode chips; and ▲ 'Dual-mode Analysis System' technology, which simultaneously measures electrical signals from below and observes cell activity with light (calcium imaging) from above, allowing for the simultaneous verification of the functional operation of interlayer connections through multiple methods.
< Figure 1. Platform integrating brain-structure-mimicking neural network model construction and functional measurement technology>
The research team successfully implemented a three-layered mini-brain structure using 3D printing with a fibrin hydrogel, which has elastic properties similar to those of the brain, and experimentally verified the process of actual neural cells transmitting and receiving signals within it.
Cortical neurons were placed in the upper and lower layers, while the middle layer was left empty but designed to allow neurons to penetrate and connect through it. Electrical signals were measured from the lower layer using a microsensor (electrode chip), and cell activity was observed from the upper layer using light (calcium imaging). The results showed that when electrical stimulation was applied, neural cells in both upper and lower layers responded simultaneously. When a synapse-blocking agent (synaptic blocker) was introduced, the response decreased, proving that the neural cells were genuinely connected and transmitting signals.
Professor Je-Kyun Park of KAIST explained, "This research is a joint development achievement of an integrated platform that can simultaneously reproduce the complex multilayered structure and function of brain tissue. Compared to existing technologies where signal measurement was impossible for more than 14 days, this platform maintains a stable microelectrode chip interface for over 27 days, allowing the real-time analysis of structure-function relationships. It can be utilized in various brain research fields such as neurological disease modeling, brain function research, neurotoxicity assessment, and neuroprotective drug screening in the future."
The research, in which Dr. Soo Jee Kim and Dr. Dongjo Yoon from KAIST's Department of Bio and Brain Engineering participated as co-first authors, was published online in the international journal 'Biosensors and Bioelectronics' on June 11, 2025.
※Paper: Hybrid biofabrication of multilayered 3D neuronal networks with structural and functional interlayer connectivity
※DOI: https://doi.org/10.1016/j.bios.2025.117688
2025.07.16 View 588 -
A KAIST Team Engineers a Microbial Platform for Efficient Lutein Production
<(From Left) Ph.D. Candidate Hyunmin Eun, Distinguished Professor Sang Yup Lee, , Dr. Cindy Pricilia Surya Prabowo>
The application of systems metabolic engineering strategies, along with the construction of an electron channeling system, has enabled the first gram-per-liter scale production of lutein from Corynebacterium glutamicum, providing a viable alternative to plant-derived lutein production.
A research group at KAIST has successfully engineered a microbial strain capable of producing lutein at industrially relevant levels. The team, led by Distinguished Professor Sang Yup Lee from the Department of Chemical and Biomolecular Engineering, developed a novel C. glutamicum strain using systems metabolic engineering strategies to overcome the limitations of previous microbial lutein production efforts. This research is expected to be beneficial for the efficient production of other industrially important natural products used in food, pharmaceuticals, and cosmetics.
Lutein is a xanthophyll carotenoid found in egg yolk, fruits, and vegetables, known for its role in protecting our eyes from oxidative stress and reducing the risk of macular degeneration and cataracts. Currently, commercial lutein is predominantly extracted from marigold flowers; however, this approach has several drawbacks, including long cultivation times, high labor costs, and inefficient extraction yields, making it economically unfeasible for large-scale production. These challenges have driven the demand for alternative production methods.
To address these issues, KAIST researchers, including Ph.D. Candidate Hyunmin Eun, Dr. Cindy Pricilia Surya Prabowo, and Distinguished Professor Sang Yup Lee, applied systems metabolic engineering strategies to engineer C. glutamicum, a GRAS (Generally Recognized As Safe) microorganism widely used in industrial fermentation. Unlike Escherichia coli, which was previously explored for microbial lutein production, C. glutamicum lacks endotoxins, making it a safer and more viable option for food and pharmaceutical applications.
The team’s work, entitled “Gram-per-litre scale production of lutein by engineered Corynebacterium,” was published in Nature Synthesis on 04 July , 2025.
This research details the high-level production of lutein using glucose as a renewable carbon source via systems metabolic engineering. The team focused on eliminating metabolic bottlenecks that previously limited microbial lutein synthesis. By employing enzyme scaffold-based electron channeling strategies, the researchers improved metabolic flux towards lutein biosynthesis while minimizing unwanted byproducts.
<Lutein production metabolic pathway engineering>
To enhance productivity, bottleneck enzymes within the metabolic pathway were identified and optimized. It was determined that electron-requiring cytochrome P450 enzymes played a major role in limiting lutein biosynthesis. To overcome this limitation, an electron channeling strategy was implemented, where engineered cytochrome P450 enzymes and their reductase partners were spatially organized on synthetic scaffolds, allowing more efficient electron transfer and significantly increasing lutein production.
The engineered C. glutamicum strain was further optimized in fed-batch fermentation, achieving a record-breaking 1.78 g/L of lutein production within 54 hours, with a content of 19.51 mg/gDCW and a productivity of 32.88 mg/L/h—the highest lutein production performance in any host reported to date. This milestone demonstrates the feasibility of replacing plant-based lutein extraction with microbial fermentation technology.
“We can anticipate that this microbial cell factory-based mass production of lutein will be able to replace the current plant extraction-based process,” said Ph.D. Candidate Hyunmin Eun. He emphasized that the integrated metabolic engineering strategies developed in this study could be broadly applied for the efficient production of other valuable natural products used in pharmaceuticals and nutraceuticals.
<Schematic diagram of microbial-based lutein production platform>
“As maintaining good health in an aging society becomes increasingly important, we expect that the technology and strategies developed here will play pivotal roles in producing other medically and nutritionally significant natural products,” added Distinguished Professor Sang Yup Lee.
This work is supported by the Development of Next-generation Biorefinery Platform Technologies for Leading Bio-based Chemicals Industry project 2022M3J5A1056072 and the Development of Platform Technologies of Microbial Cell Factories for the Next-Generation Biorefineries project 2022M3J5A1056117 from the National Research Foundation supported by the Korean Ministry of Science and ICT.
Source:
Hyunmin Eun (1st), Cindy Pricilia Surya Prabowo (co-1st), and Sang Yup Lee (Corresponding). “Gram-per-litre scale production of lutein by engineered Corynebacterium”. Nature Synthesis (Online published)
For further information:
Sang Yup Lee, Distinguished Professor of Chemical and Biomolecular Engineering, KAIST (leesy@kaist.ac.kr, Tel: +82-42-350-3930)
2025.07.14 View 1187 -
Professor Jung-woo' Choi ‘s Team Comes in First at the World's Top Acoustic AI Challenge
<Photo1. (From left) Ph.D candidate Yong-hoo Kwon, M.S candidate Do-hwan Kim, Professor Jung-woo Choi, Dr. Dong-heon Lee>
'Acoustic separation and classification technology' is a next-generation artificial intelligence (AI) core technology that enables the early detection of abnormal sounds in areas such as drones, fault detection of factory pipelines, and border surveillance systems, or allows for the separation and editing of spatial audio by sound source when producing AR/VR content.
On the 11th of July, a research team led by Professor Jung-woo Choi of KAIST's Department of Electrical and Electronic Engineering won first place in the 'Spatial Semantic Segmentation of Sound Scenes' task of the 'DCASE2025 Challenge,' the world's most prestigious acoustic detection and analysis competition.
This year’s challenge featured 86 teams competing across six tasks. In this competition, the KAIST research team achieved the best performance in their first-ever participation to Task 4. Professor Jung-woo Choi’s research team consisted of Dr. Dong-heon, Lee, Ph.D. candidate Young-hoo Kwon, and M.S. candidate Do-hwan Kim.
Task 4 titled 'Spatial Semantic Segmentation of Sound Scenes' is a highly demanding task requiring the analysis of spatial information in multi-channel audio signals with overlapping sound sources. The goal was to separate individual sounds and classify them into 18 predefined categories. The research team plans to present their technology at the DCASE workshop in Barcelona this October.
<Figure 1. Example of an acoustic scene with multiple mixed sounds>
Early this year, Dr. Dong-heon Lee developed a state-of-the-art sound source separation AI that combines Transformer and Mamba architectures. During the competition, centered around researcher Young-hoo Kwon, they completed a ‘chain-of-inference architecture' AI model that performs sound source separation and classification again, using the waveforms and types of the initially separated sound sources as clues. This AI model is inspired by human’s auditory scene analysis mechanism that isolates individual sounds by focusing on incomplete clues such as sound type, rhythm, or direction, when listening to complex sounds.
Through this, the team was the only participant to achieve double-digit performance (11 dB) in 'Class-Aware Signal-to-Distortion Ratio Improvement (CA-SDRi)*,' which is the measure for ranking how well the AI separated and classified sounds, proving their technical excellence.
Class-Aware Signal-to-Distortion Ratio Improvement (CA-SDRi): Measures how much clearer (less distorted) the desired sound is separated and classified compared to the original audio, in dB (decibels). A higher number indicates more accurate and cleaner sound separation.
Prof. Jung-woo Choi remarked, "The research team has showcased world-leading acoustic separation AI models for the past three years, and I am delighted that these results have been officially recognized." He added, "I am proud of every member of the research team for winning first place through focused research, despite the significant increase in difficulty and having only a few weeks for development."
<Figure 2. Time-frequency patterns of sound sources separated from a mixed source>
The IEEE DCASE Challenge 2025 was held online, with submissions accepted from April 1 to June 15 and results announced on June 30. Since its launch in 2013, the DCASE Challenge has served as a premier global platform of IEEE Signal Processing Society for showcasing cutting-edge AI models in acoustic signal processing.
This research was supported by the Mid-Career Researcher Support Project and STEAM Research Project of the National Research Foundation of Korea, funded by the Ministry of Education, Science and Technology, as well as support from the Future Defense Research Center, funded by the Defense Acquisition Program Administration and the Agency for Defense Development.
2025.07.13 View 490 -
KAIST Presents a Breakthrough in Overcoming Drug Resistance in Cancer – Hope for Treating Intractable Diseases like Diabetes
<(From the left) Prof. Hyun Uk Kim, Ph.D candiate Hae Deok Jung, Ph.D candidate Jina Lim, Prof.Yoosik Kim from the Department of Chemical and Biomolecular Engineering>
One of the biggest obstacles in cancer treatment is drug resistance in cancer cells. Conventional efforts have focused on identifying new drug targets to eliminate these resistant cells, but such approaches can often lead to even stronger resistance. Now, researchers at KAIST have developed a computational framework to predict key metabolic genes that can re-sensitize resistant cancer cells to treatment. This technique holds promise not only for a variety of cancer therapies but also for treating metabolic diseases such as diabetes.
On the 7th of July, KAIST (President Kwang Hyung Lee) announced that a research team led by Professors Hyun Uk Kim and Yoosik Kim from the Department of Chemical and Biomolecular Engineering had developed a computational framework that predicts metabolic gene targets to re-sensitize drug-resistant breast cancer cells. This was achieved using a metabolic network model capable of simulating human metabolism.
Focusing on metabolic alterations—key characteristics in the formation of drug resistance—the researchers developed a metabolism-based approach to identify gene targets that could enhance drug responsiveness by regulating the metabolism of drug-resistant breast cancer cells.
< Computational framework that can identify metabolic gene targets to revert the metabolic state of the drug-resistant cells to that of the drug-sensitive parental cells>
The team first constructed cell-specific metabolic network models by integrating proteomic data obtained from two different types of drug-resistant MCF7 breast cancer cell lines: one resistant to doxorubicin and the other to paclitaxel. They then performed gene knockout simulations* on all of the metabolic genes and analyzed the results.
*Gene knockout simulation: A computational method to predict changes in a biological network by virtually removing specific genes.
As a result, they discovered that suppressing certain genes could make previously resistant cancer cells responsive to anticancer drugs again. Specifically, they identified GOT1 as a target in doxorubicin-resistant cells, GPI in paclitaxel-resistant cells, and SLC1A5 as a common target for both drugs.
The predictions were experimentally validated by suppressing proteins encoded by these genes, which led to the re-sensitization of the drug-resistant cancer cells.
Furthermore, consistent re-sensitization effects were also observed when the same proteins were inhibited in other types of breast cancer cells that had developed resistance to the same drugs.
Professor Yoosik Kim remarked, “Cellular metabolism plays a crucial role in various intractable diseases including infectious and degenerative conditions. This new technology, which predicts metabolic regulation switches, can serve as a foundational tool not only for treating drug-resistant breast cancer but also for a wide range of diseases that currently lack effective therapies.”
Professor Hyun Uk Kim, who led the study, emphasized, “The significance of this research lies in our ability to accurately predict key metabolic genes that can make resistant cancer cells responsive to treatment again—using only computer simulations and minimal experimental data. This framework can be widely applied to discover new therapeutic targets in various cancers and metabolic diseases.”
The study, in which Ph.D. candidates JinA Lim and Hae Deok Jung from KAIST participated as co-first authors, was published online on June 25 in Proceedings of the National Academy of Sciences (PNAS), a leading multidisciplinary journal that covers top-tier research in life sciences, physics, engineering, and social sciences.
※ Title: Genome-scale knockout simulation and clustering analysis of drug-resistant breast cancer cells reveal drug sensitization targets ※ DOI: https://doi.org/10.1073/pnas.2425384122 ※ Authors: JinA Lim (KAIST, co-first author), Hae Deok Jung (KAIST, co-first author), Han Suk Ryu (Seoul National University Hospital, corresponding author), Yoosik Kim (KAIST, corresponding author), Hyun Uk Kim (KAIST, corresponding author), and five others.
This research was supported by the Ministry of Science and ICT through the National Research Foundation of Korea, and the Electronics and Telecommunications Research Institute (ETRI).
2025.07.08 View 1191 -
Professor Moon-Jeong Choi Appointed as an Advisor for the ITU's 'AI for Good Global Summit'
Professor Moon-Jeong Choi from KAIST’s Graduate School of Science and Technology Policy has been appointed as an advisor for "Innovate for Impact" at the AI for Good Global Summit, organized by the International Telecommunication Union (ITU), a specialized agency of the United Nations (UN).
The ITU is the UN's oldest specialized agency in the field of information and communication technology (ICT) and serves as a crucial body for coordinating global ICT policies and standards.
This advisory committee was formed to explore global cooperation strategies for realizing the social value of Artificial Intelligence (AI) and promoting sustainable development. Experts from around the world are participating as committee members, with Professor Choi being the sole Korean representative.
<Moon-Jeong Choi from KAIST’s Graduate School of Science and Technology Policy>
The AI for Good Global Summit is taking place in Geneva, Switzerland from July 8 to 11. It is organized by the ITU in collaboration with approximately 40 other UN-affiliated organizations. The summit aims to address global challenges facing humanity through the use of AI technology, focusing on key agenda items such as identifying AI application cases, discussing international policies and technical standards, and strengthening global partnerships.
As an "Innovate for Impact" advisor, Professor Choi will evaluate AI application cases from various countries, participating in case analyses primarily focused on public interest and social impact. The summit will move beyond discussions of technical performance to focus on how AI can contribute to the public good, with diverse case studies from around the world being debated. Notably, during a policy panel discussion at the summit, Professor Choi will discuss policy frameworks for AI transparency, inclusivity, and fairness under the theme of "Responsible AI Development."
Professor Choi commented, "I believe the social impact of technology mirrors the values and systems of each nation. As a society's core values permeate technology, the way AI is developed and used varies significantly from country to country. These differences lead to diverse manifestations of AI's impact on society." She further emphasized, "Korea's vision of becoming an AI powerhouse should not merely be about technological superiority, but rather about enhancing social capital through human-centered AI and realizing communal values that enable us to live together."
Professor Moon-Jeong Choi currently serves as the Dean of the Graduate School of Science and Technology Policy. She is also an external director for the National Information Society Agency (2023-present) and chair of the Korea-OECD Digital Society Initiative (2024-present).
For more information about the AI for Good Global Summit, please visit the official website: https://aiforgood.itu.int.
2025.07.08 View 560 -
KAIST researcher Se Jin Park develops 'SpeechSSM,' opening up possibilities for a 24-hour AI voice assistant.
<(From Left)Prof. Yong Man Ro and Ph.D. candidate Sejin Park>
Se Jin Park, a researcher from Professor Yong Man Ro’s team at KAIST, has announced 'SpeechSSM', a spoken language model capable of generating long-duration speech that sounds natural and remains consistent.
An efficient processing technique based on linear sequence modeling overcomes the limitations of existing spoken language models, enabling high-quality speech generation without time constraints.
It is expected to be widely used in podcasts, audiobooks, and voice assistants due to its ability to generate natural, long-duration speech like humans.
Recently, Spoken Language Models (SLMs) have been spotlighted as next-generation technology that surpasses the limitations of text-based language models by learning human speech without text to understand and generate linguistic and non-linguistic information. However, existing models showed significant limitations in generating long-duration content required for podcasts, audiobooks, and voice assistants. Now, KAIST researcher has succeeded in overcoming these limitations by developing 'SpeechSSM,' which enables consistent and natural speech generation without time constraints.
KAIST(President Kwang Hyung Lee) announced on the 3rd of July that Ph.D. candidate Sejin Park from Professor Yong Man Ro's research team in the School of Electrical Engineering has developed 'SpeechSSM,' a spoken. a spoken language model capable of generating long-duration speech.
This research is set to be presented as an oral paper at ICML (International Conference on Machine Learning) 2025, one of the top machine learning conferences, selected among approximately 1% of all submitted papers. This not only proves outstanding research ability but also serves as an opportunity to once again demonstrate KAIST's world-leading AI research capabilities.
A major advantage of Spoken Language Models (SLMs) is their ability to directly process speech without intermediate text conversion, leveraging the unique acoustic characteristics of human speakers, allowing for the rapid generation of high-quality speech even in large-scale models.
However, existing models faced difficulties in maintaining semantic and speaker consistency for long-duration speech due to increased 'speech token resolution' and memory consumption when capturing very detailed information by breaking down speech into fine fragments.
To solve this problem, Se Jin Park developed 'SpeechSSM,' a spoken language model using a Hybrid State-Space Model, designed to efficiently process and generate long speech sequences.
This model employs a 'hybrid structure' that alternately places 'attention layers' focusing on recent information and 'recurrent layers' that remember the overall narrative flow (long-term context). This allows the story to flow smoothly without losing coherence even when generating speech for a long time. Furthermore, memory usage and computational load do not increase sharply with input length, enabling stable and efficient learning and the generation of long-duration speech.
SpeechSSM effectively processes unbounded speech sequences by dividing speech data into short, fixed units (windows), processing each unit independently, and then combining them to create long speech.
Additionally, in the speech generation phase, it uses a 'Non-Autoregressive' audio synthesis model (SoundStorm), which rapidly generates multiple parts at once instead of slowly creating one character or one word at a time, enabling the fast generation of high-quality speech.
While existing models typically evaluated short speech models of about 10 seconds, Se Jin Park created new evaluation tasks for speech generation based on their self-built benchmark dataset, 'LibriSpeech-Long,' capable of generating up to 16 minutes of speech.
Compared to PPL (Perplexity), an existing speech model evaluation metric that only indicates grammatical correctness, she proposed new evaluation metrics such as 'SC-L (semantic coherence over time)' to assess content coherence over time, and 'N-MOS-T (naturalness mean opinion score over time)' to evaluate naturalness over time, enabling more effective and precise evaluation.
Through these new evaluations, it was confirmed that speech generated by the SpeechSSM spoken language model consistently featured specific individuals mentioned in the initial prompt, and new characters and events unfolded naturally and contextually consistently, despite long-duration generation. This contrasts sharply with existing models, which tended to easily lose their topic and exhibit repetition during long-duration generation.
PhD candidate Sejin Park explained, "Existing spoken language models had limitations in long-duration generation, so our goal was to develop a spoken language model capable of generating long-duration speech for actual human use." She added, "This research achievement is expected to greatly contribute to various types of voice content creation and voice AI fields like voice assistants, by maintaining consistent content in long contexts and responding more efficiently and quickly in real time than existing methods."
This research, with Se Jin Park as the first author, was conducted in collaboration with Google DeepMind and is scheduled to be presented as an oral presentation at ICML (International Conference on Machine Learning) 2025 on July 16th.
Paper Title: Long-Form Speech Generation with Spoken Language Models
DOI: 10.48550/arXiv.2412.18603
Ph.D. candidate Se Jin Park has demonstrated outstanding research capabilities as a member of Professor Yong Man Ro's MLLM (multimodal large language model) research team, through her work integrating vision, speech, and language. Her achievements include a spotlight paper presentation at 2024 CVPR (Computer Vision and Pattern Recognition) and an Outstanding Paper Award at 2024 ACL (Association for Computational Linguistics).
For more information, you can refer to the publication and accompanying demo: SpeechSSM Publications.
2025.07.04 View 1112 -
KAIST Develops AI to Easily Find Promising Materials That Capture Only CO₂
< Photo 1. (From left) Professor Jihan Kim, Ph.D. candidate Yunsung Lim and Dr. Hyunsoo Park of the Department of Chemical and Biomolecular Engineering >
In order to help prevent the climate crisis, actively reducing already-emitted CO₂ is essential. Accordingly, direct air capture (DAC) — a technology that directly extracts only CO₂ from the air — is gaining attention. However, effectively capturing pure CO₂ is not easy due to water vapor (H₂O) present in the air. KAIST researchers have successfully used AI-driven machine learning techniques to identify the most promising CO₂-capturing materials among metal-organic frameworks (MOFs), a key class of materials studied for this technology.
KAIST (President Kwang Hyung Lee) announced on the 29th of June that a research team led by Professor Jihan Kim from the Department of Chemical and Biomolecular Engineering, in collaboration with a team at Imperial College London, has developed a machine-learning-based simulation method that can quickly and accurately screen MOFs best suited for atmospheric CO₂ capture.
< Figure 1. Concept diagram of Direct Air Capture (DAC) technology and carbon capture using Metal-Organic Frameworks (MOFs). MOFs are promising porous materials capable of capturing carbon dioxide from the atmosphere, drawing attention as a core material for DAC technology. >
To overcome the difficulty of discovering high-performance materials due to the complexity of structures and the limitations of predicting intermolecular interactions, the research team developed a machine learning force field (MLFF) capable of precisely predicting the interactions between CO₂, water (H₂O), and MOFs. This new method enables calculations of MOF adsorption properties with quantum-mechanics-level accuracy at vastly faster speeds than before.
Using this system, the team screened over 8,000 experimentally synthesized MOF structures, identifying more than 100 promising candidates for CO₂ capture. Notably, this included new candidates that had not been uncovered by traditional force-field-based simulations. The team also analyzed the relationships between MOF chemical structure and adsorption performance, proposing seven key chemical features that will help in designing new materials for DAC.
< Figure 2. Concept diagram of adsorption simulation using Machine Learning Force Field (MLFF). The developed MLFF is applicable to various MOF structures and allows for precise calculation of adsorption properties by predicting interaction energies during repetitive Widom insertion simulations. It is characterized by simultaneously achieving high accuracy and low computational cost compared to conventional classical force fields. >
This research is recognized as a significant advance in the DAC field, greatly enhancing materials design and simulation by precisely predicting MOF-CO₂ and MOF-H₂O interactions.
The results of this research, with Ph.D. candidate Yunsung Lim and Dr. Hyunsoo Park of KAIST as co-first authors, were published in the international academic journal Matter on June 12.
※Paper Title: Accelerating CO₂ direct air capture screening for metal–organic frameworks with a transferable machine learning force field
※DOI: 10.1016/j.matt.2025.102203
This research was supported by the Saudi Aramco-KAIST CO₂ Management Center and the Ministry of Science and ICT's Global C.L.E.A.N. Project.
2025.06.29 View 1481 -
New and Highly Efficient Recycling Technology to Turn Used Tires into Raw Materials for Rubber and Nylon
< (From left) Kyungmin Choi (MS-Ph.D. integrated course, Department of Chemistry), Dr. Beomsoon Park, Professor Soon Hyeok Hong, Dr. Kyoungil Cho >
Approximately 1.5 billions of tires are discarded globally every year, and this is identified as one of the major causes of serious environmental pollution. The research team at the Department of Chemistry at KAIST has achieved a breakthrough by selectively converting waste tires into high-purity cyclic alkenes, valuable chemical building blocks used in the production of rubber and nylon fibers. This advance marks a new milestone in chemical recycling technology for waste tires.
The team, led by Professor Soon Hyeok Hong, has developed a dual-catalyst-based reaction system that overcomes the long-standing challenges associated with recycling vulcanized rubber materials.
Tires are composed of complex blends of synthetic and natural rubber, and their physical strength and durability are reinforced with additives such as silica, carbon black, and antioxidants. In particular, cross-linking between rubber chains is formed through the vulcanization process, giving them a structure resistant to heat and pressure, which is one of the main reasons why chemical recycling of waste tires is difficult.
Until now, waste tire recycling has mainly relied on pyrolysis or mechanical recycling methods. The pyrolysis method is a technology that decomposes polymer chains at high temperatures of 350-800°C to convert them into fuel oil, but it clearly has limitations such as high energy consumption, low selectivity, and the production of low-quality hydrocarbon mixtures.
To solve these problems, the research team developed a method to convert waste rubber into useful chemicals using dual catalysis. The first catalyst helps to break down rubber molecules by changing their bonding structure, and the second catalyst creates cyclic compounds through a ring-closing reaction.
This process shows high selectivity of up to 92% and a yield of 82%. The produced cyclopentene can be recycled into rubber, and cyclohexene can be used as a raw material for nylon fibers, making them industrially very valuable.
The research team successfully applied the developed system to discarded waste tires, achieving selective conversion into high-purity cyclic alkenes. Unlike the existing pyrolysis method, this is evaluated as a new turning point in the field of waste tire recycling as it can produce high-value chemicals through low-temperature precision catalytic reactions.
In addition, this catalytic platform is compatible with a wide range of synthetic and waste rubbers, positioning it as a promising foundation for scalable, circular solutions in the polymer and materials industries.
< Figure 1. Development of a Catalytic Method for Chemical Recycling of Waste Rubber >
Professor Hong stated, "This research offers an innovative solution for the chemical recycling of waste tires. We aim to develop next-generation high-efficiency catalysts and lay the groundwork for commercialization to enhance economic feasibility. Ultimately, our goal is to contribute to solving the broader waste plastic problem through fundamental chemistry."
This research, in which Beomsoon Park, Kyoungil Cho, and Kyungmin Choi participated, was supported by the National Research Foundation of Korea and was published online in the internationally renowned academic journal ‘Chem’ on June 18th.
※Paper Title: Catalytic and Selective Chemical Recycling of Post-Consumer Rubbers into Cycloalkenes
※DOI: 10.1016/j.chempr.2025.102625
2025.06.26 View 2523 -
Military Combatants Usher in an Era of Personalized Training with New Materials
< Photo 1. (From left) Professor Steve Park of Materials Science and Engineering, Kyusoon Pak, Ph.D. Candidate (Army Major) >
Traditional military training often relies on standardized methods, which has limited the provision of optimized training tailored to individual combatants' characteristics or specific combat situations. To address this, our research team developed an e-textile platform, securing core technology that can reflect the unique traits of individual combatants and various combat scenarios. This technology has proven robust enough for battlefield use and is economical enough for widespread distribution to a large number of troops.
On June 25th, Professor Steve Park's research team at KAIST's Department of Materials Science and Engineering announced the development of a flexible, wearable electronic textile (E-textile) platform using an innovative technology that 'draws' electronic circuits directly onto fabric.
The wearable e-textile platform developed by the research team combines 3D printing technology with new materials engineering design to directly print flexible and highly durable sensors and electrodes onto textile substrates. This enables the collection of precise movement and human body data from individual combatants, which can then be used to propose customized training models.
Existing e-textile fabrication methods were often complex or limited in their ability to provide personalized customization. To overcome these challenges, the research team adopted an additive manufacturing technology called 'Direct Ink Writing (DIW)' 3D printing.
< Figure 1. Schematic diagram of e-textile manufactured with Direct Ink Writing (DIW) printing technology on various textiles, including combat uniforms >
This technology involves directly dispensing and printing special ink, which functions as sensors and electrodes, onto textile substrates in desired patterns. This allows for flexible implementation of various designs without the complex process of mask fabrication. This is expected to be an effective technology that can be easily supplied to hundreds of thousands of military personnel.
The core of this technology lies in the development of high-performance functional inks based on advanced materials engineering design. The research team combined styrene-butadiene-styrene (SBS) polymer, which provides flexibility, with multi-walled carbon nanotubes (MWCNT) for electrical conductivity. They developed a tensile/bending sensor ink that can stretch up to 102% and maintain stable performance even after 10,000 repetitive tests. This means that accurate data can be consistently obtained even during the strenuous movements of combatants.
< Figure 2. Measurement of human movement and breathing patterns using e-textile >
Furthermore, new material technology was applied to implement 'interconnect electrodes' that electrically connect the upper and lower layers of the fabric. The team developed an electrode ink combining silver (Ag) flakes with rigid polystyrene (PS) polymer, precisely controlling the impregnation level (how much the ink penetrates the fabric) to effectively connect both sides or multiple layers of the fabric. This secures the technology for producing multi-layered wearable electronic systems integrating sensors and electrodes.
< Figure 3. Experimental results of recognizing unknown objects after machine learning six objects using a smart glove >
The research team proved the platform's performance through actual human movement monitoring experiments. They printed the developed e-textile on major joint areas of clothing (shoulders, elbows, knees) and measured movements and posture changes during various exercises such as running, jumping jacks, and push-ups in real-time.
Additionally, they demonstrated the potential for applications such as monitoring breathing patterns using a smart mask and recognizing objects through machine learning and perceiving complex tactile information by printing multiple sensors and electrodes on gloves. These results show that the developed e-textile platform is effective in precisely understanding the movement dynamics of combatants.
This research is an important example demonstrating how cutting-edge new material technology can contribute to the advancement of the defense sector. Major Kyusoon Pak of the Army, who participated in this research, considered required objectives such as military applicability and economic feasibility for practical distribution from the research design stage.
< Figure 4. Experimental results showing that a multi-layered e-textile glove connected with interconnect electrodes can measure tensile/bending signals and pressure signals at a single point >
Major Pak stated, "Our military is currently facing both a crisis and an opportunity due to the decrease in military personnel resources caused by the demographic cliff and the advancement of science and technology. Also, respect for life in the battlefield is emerging as a significant issue. This research aims to secure original technology that can provide customized training according to military branch/duty and type of combat, thereby enhancing the combat power and ensuring the survivability of our soldiers."
He added, "I hope this research will be evaluated as a case that achieved both scientific contribution and military applicability."
This research, where Kyusoon Pak, Ph.D. Candidate (Army Major) from KAIST's Department of Materials Science and Engineering, participated as the first author and Professor Steve Park supervised, was published on May 27, 2025, in `npj Flexible Electronics (top 1.8% in JCR field)', an international academic journal in the electrical, electronic, and materials engineering fields.
* Paper Title: Fabrication of Multifunctional Wearable Interconnect E-textile Platform Using Direct Ink Writing (DIW) 3D Printing
* DOI: https://doi.org/10.1038/s41528-025-00414-7
This research was supported by the Ministry of Trade, Industry and Energy and the National Research Foundation of Korea.
2025.06.25 View 2146