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Scientist of October, Professor Haeshin Lee
(Professor Haeshin Lee from the Department of Chemistry) Professor Haeshin Lee from the Department of Chemistry received the ‘Science and Technology Award of October’ from the Ministry of Science and ICT and the National Research Foundation of Korea for his contribution to developing an antibleeding injection needle. This novel outcome will fundamentally prevent the problem of secondary infections of AIDS, Ebola and Hepatitis viruses transmitting from patients to medical teams. This needle’s surface is coated with hemostatic materials. Its concept is simple and the key to this technology is to make materials that are firmly coated on the needle so that they can endure frictional force when being injected into skin and blood vessels. Moreover, the materials should be adhesive to skin and the interior of blood vessels, but harmless to humans. Professor Lee found a solution from natural polymer ingredients. Catecholamine can be found in mussels. Professor Lee conjugated catechol groups on the chitosan backbone. He applied this mussel-inspired adhesive polymer Chitosan-catechol, which immediately forms an adhesive layer with blood, as a bioadhesion for the antibleeding injection needle. Professor Lee said, “Chitosan-catechol, which copies the adhesive mechanism of mussels, shows high solubility in physiological saline as well as great mucoadhesion. Hence, it is perfectly suitable for coating the injection needle. Combining it with proteins allows for efficient drug delivery to the heart, which is a challenging injection location, so it will be also useful for treating incurable heart disease.”
2018.10.05
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The 1st Korea Toray Science and Technology Awardee, Prof. Sukbok Chang
(Distinguished Professor Sukbok Chang from the Department of Chemistry) The Korea Toray Science Foundation (KTSF) awarded the first Korea Toray Science Technology Award in basic science to Distinguished Professor Sukbok Chang from the Department of Chemistry on September 19. KTSF was established in January 2018, and its award goes to researchers who have significantly contributed to the development of chemistry and materials research with funds to support research projects. Distinguished Professor Chang has devoted himself in organocatalysis research; in particular, his work on catalysts for effective lactam formation, which was an intricate problem, received great attention. The award ceremony will take place in The Federation of Korean Industries Hall on October 31. KTFS board members, judges, and the CEO of Toray Industries Akihiro Nikkaku will attend the ceremony. Also, Dr. Ryoji Noyori, the Nobel Laureate in Chemistry, will give a talk on the role of chemistry and creative challenges as a researcher.
2018.10.04
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Professor Hee-Sung Park Named Scientist of May
(Professor Hee-Sung Park) Professor Hee-Sung Park from the Department of Chemistry was named ‘Scientist of May’ sponsored by the Ministry of Science and ICT and the National Research Foundation of Korea. Professor Park was honored in recognition of his developing a tool to engineer designer proteins via diverse chemical modifications. This approach provides a novel platform for investigating numerous diseases such as cancer and dementia. His research focuses on the production of synthetic proteins and the generation of diverse protein functions as well as the designing and engineering of new translation machinery for genetic code expansion, and the application of synthetic biology techniques for basic cell biology and applied medical science. Post-translational modifications (PTMs) are constantly taking place during or after protein biosynthesis. PTMs play a vital role in expanding protein functional diversity and, as a result, critically affect numerous biological processes. Abnormal PTMs have been known to trigger various diseases including cancer and dementia. Therefore, this technology enables proteins to reproduce with specific modifications at selected residues and will significantly help establish experimental strategies to investigate fundamental biological mechanisms including the development of targeted cancer therapies. Professor Park also received 10 million KRW in prize money.
2018.05.04
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Undergrad's Paper Chosen as the Cover Article in Soft Matter
(from left: Research Professor KyuHan Kim and Undergrad Student Subeen Kim) A KAIST undergraduate student, Subeen Kim, had his paper chosen as the cover article in an international journal during his senior year. There have been an increasing number of undergraduate students who were published as the first author because the KAIST Undergraduate Research Participation program allows more active research participation by undergraduate students. Through URP, Kim successfully published his paper in the internationally-renowned journal, Soft Matter, which is published by the Royal Society of Chemistry, and it was chosen as the cover article of that journal in February 2018. This publication means a lot to him because he designed the cover image himself, based on his imagination and observations. His research is about controllable one-step double emulsion formation. Double emulsion is a system in which dispersed droplets contain additional immiscible liquid droplets. Having great retention ability, double emulsion has been used in various applications in the food industry, in cosmetics, and for drug delivery. Nevertheless, two-step emulsification is a conventional approach to produce double emulsions that typically leads to partial destabilization of the emulsion formed during the initial stage. Hence, it does not ensure the stability of a double emulsion. On the other hand, a microfluidic approach with various flow-focusing techniques has been developed, but it has low production efficiency and thus limited industrial applications. Kim’s results came from the process of phase inversion to solve this problem. He identified the instant formation of double emulsions during the process of phase inversion. Based on this finding, he proposed criteria to achieve high stability of double emulsion. Through constant research, he developed a quite general method using a combination of an oil soluble poly methyl methacrylate (PMMA) and hydrophobic silica nanoparticle (HDK H18). This new method enables one-step and stable production of double emersions in a stable manner. It also allows control of the number and the volume of inner oil droplets inside the outer water droplets by adjusting PMMA and HDK H18. Kim enrolled at KAIST as a KAIST Presidential Fellowship and Presidential Science Scholarship in 2014. While studying both chemical and biomolecular engineering and chemistry he has been developing his hypothesis and conducting research. He was able to begin conducting research because he has taken part in URP projects twice. In his sophomore year, he studied the formation of high internal phase double emulsions. After one year, he conducted research to produce superabsorbent resins, which are the base material for diapers, by using colloid particles. Using partial research outcomes, he published his paper in Nature Communications as a second author. Kim said, “Double majoring the chemical and biomolecular engineering and chemistry has helped me producing this outcome. I hope that this research contributes to commercializing double emulsions. I will continue to identify accurate principles to produce chemicals that can be controlled exquisitely.” Figure 1. The cover article of Soft Matter
2018.05.03
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Scientist of March, Professor Hee-Seung Lee
(Professor Hee-Seung Lee) Professor Hee-Seung Lee from the Department of Chemistry at KAIST received the ‘Science and Technology Award of the Month’ awarded by the Ministry of ICT and Science, and the National Research Foundation of Korea for March 2018. Professor Lee has been recognized for successfully producing peptide-based molecular machines, which used to be made of metals. The methodology can be translated into magnetotactic behavior at the macroscopic scale, which is reminiscent of magnetosomes in magnetotactic bacteria. The team employed foldectures, self-assembled molecular architectures of β-peptide foldamers, to develop the peptide-based molecular machines that uniformly align with respect to an applied static magnetic field. Professor Lee said, “Molecular machines are widely used in the field of medical engineering or material science; however, there were limitations for developing the machines using magnetic fields. By developing peptide-based molecular machines, we were able to develop body-friendly molecular machines.” Every month, the Ministry of ICT and Science and the National Research Foundation of Korea award a cash prize worth 10,000,000 KRW to a scientist who has contributed to science and technology with outstanding research and development performance.
2018.03.15
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KAISTian of the Year 2016: Professor Hee-Sung Park
Professor Hee-Sung Park of the Department of Chemistry has been named the KAISTian of 2016. President Sung-Mo Kang awarded him at the New Year ceremony on January 2, 2017. The KAISTian of the Year recognizes the most outstanding professor whose research and scholarship made significant achievements for the year. The Selection Committee announced that Professor Park was chosen as the 16th awardee in recognition of his developing new methods to incorporate unnatural amino acids into proteins. Earning his Ph.D. in chemical engineering at KAIST in 2000, Professor Park has been a professor at KAIST since 2009. His research focuses on the production of synthetic proteins and the generation of diverse protein functions as well as the designing and engineering of new translation machinery for genetic code expansion, and the application of synthetic biology techniques for basic cell biology and applied medical science. He developed a tool to engineer designer proteins via diverse chemical modifications, providing a novel platform for investigating numerous diseases such as cancer and dementia. Post-translational modifications (PTMs) are constantly taking place during or after protein biosynthesis. PTMs play a vital role in expanding protein functional diversity and, as a result, critically affect numerous biological processes. Abnormal PTMs have been known to trigger various diseases including cancer and dementia. Therefore, this technology, that enables proteins to reproduce with specific modifications at selected residues, will significantly help establish experimental strategies to investigate fundamental biological mechanisms including the development of targeted cancer therapies. Professor Park’s research results appeared in the September 28, 2016 edition of Science. For more on Professor Park's research, please visit: http://kaistcompass.kaist.ac.kr/?issues=fall-2016&magazine=a-chemical-biology-route-to-site-specific-authentic-protein-modifications http://science.sciencemag.org/content/early/2016/09/28/science.aah4428 http://www.kaist.ac.kr/html/en/news/podcast.html (Podcast: Season 6 Episode 7: When good proteins go bad )
2017.01.10
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Professors Sukbok Chang and Jang-Wook Choi Receive the 2015 Knowledge Award from the Korean Government
The Ministry of Science, ICT and Future Planning (MISP) of the Republic of Korea announced the 2015 Knowledge Awards on October 20, 2015. Two KAIST professors received the award. Established in 2009, the awards are presented to Korean scientists whose publications have contributed to the international science community. Specifically, the MISP used the two biggest science databases, Science Citation Index Expanded (SCIE) and Scopus, to identify ten highly cited papers ranked in the top 1% by total citations in the past ten years. Professor Sukbok Chang of Chemistry (left in the picture below) is a global authority in the field of catalytic hydrocarbon functionalization. His paper entitled “Palladium-catalyzed C-H Functionalization of Pyridine N-Oxides: Highly Selective Alkenylation and Direct Arylation with Unactivated Arenes,” which was published in the Journal of the American Chemical Society in 2008, was once selected by Thomson Reuters as one of the “Most Influential Research Papers of the Month.” In 2011, the American Chemical Society included his paper in the list of the top 20 research papers that were most frequently cited in the last three years. Professor Jang-Wook Choi of the Graduate School of EEWS (Energy, Environment, Water, and Sustainability) has been known for his leading research in rechargeable battery, supercapacitor, and materials chemistry. In particular, his work on secondary fuel cells attracted significant attention from academia and industry in Korea. Professor Choi developed a super-thin flexible lithium-ion battery this year, thinner than a credit card, which lasts longer than the existing batteries and with greater performance. He also developed new electrode materials for next-generation sodium-ion and magnesium secondary fuel cells. Professor Sukbok Chang (left) and Professor Jang-Wook Choi (right)
2015.10.23
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Thomson Reuters Nominates Distinguished Professor Ryong Ryoo for Its 2014 Nobel Citation Laureates in Chemistry
The Intellectual Property & Science business of Thomson Reuters announced on September 25th its “2014 Citation Laureates,” a list of candidates considered likely to win the Nobel Prize in the fields of physics, chemistry, physiology or medicine, and economics. The annual Thomson Reuters Citation Laureates will be recognized in perpetuity as contenders for a Nobel Prize. Distinguished Professor Ryong Ryoo of the Department of Chemistry, KAIST, has been nominated for the 2014 Thomson Reuters Citation Laureates in Chemistry. He is the first Korean scientist who has made the list. In addition to Professor Ryoo, seven other scientists were selected as possible contenders for the 2014 Nobel Prize in Chemistry, or in the future. Professor Ryoo was named alongside Charles T. Kresge, Chief Technology Officer of Saudi Aramco, Dhahran, and Galen D. Stucky, Professor of the Department Chemistry and Biochemistry at the University of California, Santa Barbara, for their research on the design of functional mesoporous materials (http://sciencewatch.com/nobel/2014-predictions/chemistry-laureates). Mesoporous materials have high surface areas with narrow pore-sized distribution and tunable pores diameters, offering promising properties and applications in various areas including adsorption, separation, sensing, and catalysis. Professor Ryoo has focused his research interest in the synthesis of new functional nanoporous materials such as hierarchical zeolites, mesoporous silicas, carbons, and organic-inorganic composite materials that can be used for advanced applications in the production of alternative energy sources and in green chemical processes. According to the press release by the Thomson Reuters, the list of the 2014 Nobel predictions includes 27 researchers representing 27 distinct academic and research organizations across nine different countries. The annual Thomson Reuters Citation Laureates study is based on the analysis of proprietary data from the research and citation database, identifying the most influential researchers in the categories of chemistry, physics, physiology or medicine, and economics. Since its inception in 2002, the study has accurately forecasted 35 Nobel Prize winners. For the full text of the press release, please go to: http://thomsonreuters.com/press-releases/092014/2014-nobel-laureates-predictions.
2014.09.29
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Extreme Tech: Nanowire "impossible to replicate" fingerprints could eliminate fraud, counterfeit goods
Research done by Professor Hyun-Joon Song of Chemistry at KAIST on anti-counterfeit, nanoscale fingerprints generated by randomly distributed nanowires was introduced by Extreme Tech, an online global science and technology news. For the articles, please go to: Extreme Tech, March 25, 2014Nanowire ‘impossible to replicate’ fingerprints could eliminate fraud, counterfeit goods http://www.extremetech.com/extreme/179131-nanowire-impossible-to-replicate-fingerprints-could-eliminate-fraud-counterfeit-goods
2014.03.26
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Professor Suk-Bok Chang receives 14th Korea Science Award in the field of Chemistry
Professor Suk-Bok Chang from the Department of Chemistry at KAIST received the “2013 Korea Science Award” in chemistry hosted by the National Research Foundation and the Ministry of Science, ICT, and Future Planning, Republic of Korea. The Korea Science Award is a presidential award of Korea, which was first established in 1987 to recognize research excellence in natural science. Three scientists are selected for the award in every other year. Professor Chang primarily researches the catalyzing mechanism of carbon-hydrogen bonds in organic molecules. He has succeeded in making great progress in the field of organic chemistry especially in developing a new type of transition metal catalytic behavior that can be applied to low-reactivity compounds. Hydrocarbons are abundant in nature, but its unreactive nature in ambient conditions makes it unsuitable as reactant for compound synthesis. In addition, the mechanism behind transition metal catalyzed carbon-hydrogen bond synthesis has not been proven sufficiently. The prediction that fossil fuels will be depleted before the end of the century makes hydrocarbon synthesis an extremely important matter. The need for an effective hydrocarbon synthesis method inspired Professor Chang to pursue research in the transition metal catalysis method and to develop a catalytic system that would allow efficient synthesis even in ambient conditions. Professor Chang has been the lead researcher for the Institute for Basic Science’s “molecule catalysis reaction research team” since December 2012 and has been carrying out this research in KAIST.
2014.01.27
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KAIST Student Awarded Prize from Energy Saving Contest
Jun-Min Kwon, an undergraduate student in the Department of Chemistry at KAIST, was awarded a prize from the Ministry of Trade, Industry and Energy, Republic of Korea, at the 35th Energy Saving Contest which was held on November 20. The student club he has been leading was also selected as one of the best groups by the Save Energy Save Earth (SESE), a volunteer organization supported by the Korea Energy Management Corporation and the Ministry of Knowledge Economy, Republic of Korea. Kwon began promoting energy conservation through a blog and participated in related meetings and workshops as a high school student to improve the understanding on the importance of energy saving and recycling.He also received awards from the Second National Assembly Forum on Climate Change, the Korean National Science Fair, as well as the Samsung Human Tech Paper Award.
2013.12.24
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Ten Breakthroughs of the Year 2011 by Science
Porous Zeolite Crytals Science, an internationally renowned scientific journal based in the US, has recently released a special issue of “Breakthrough of the Year, 2011,” dated December 23, 2011. In the issue, the journal introduces ten most important research breakthroughs made this year, and Professor Ryong Ryoo, Department of Chemistry at KAIST, was one of the scientists behind such notable advancements in 2011. Professor Ryoo has been highly regarded internationally for his research on the development of synthetic version of zeolites, a family of porous minerals that is widely used for products such as laundry detergents, cat litters, etc. Below is the article from Science, stating the zeolite research: For Science’s “Breakthrough of the Year, 2011”, please go to: http://www.sciencemag.org/site/special/btoy2011/ [Excerpt from the December 23, 2011 Issue of Science] Industrial Molecules, Tailor-Made If you ever doubt that chemistry is still a creative endeavor, just look at zeolites. This family of porous minerals was first discovered in 1756. They"re formed from different arrangements of aluminum, silicon, and oxygen atoms that crystallize into holey structures pocked with a perfect arrangement of pores. Over the past 250 years, 40 natural zeolites have been discovered, and chemists have chipped in roughly 150 more synthetic versions. View larger version: In this page In a new window Assembly required. Porous zeolite crystals are widely used as filters and catalysts. This year, researchers found new ways to tailor the size of their pores and create thinner, cheaper membranes. CREDIT: K. VAROON ET AL., SCIENCE334, 6052 (7 OCTOBER 2001) This abundance isn"t just for show. Three million tons of zeolites are produced every year for use in laundry detergents, cat litter, and many other products. But zeolites really strut their stuff in two uses: as catalysts and molecular sieves. Oil refineries use zeolite catalysts to break down long hydrocarbon chains in oil into the shorter, volatile hydrocarbons in gasoline. And the minerals" small, regularly arranged pores make them ideal filters for purifying everything from the air on spaceships to the contaminated water around the nuclear reactors destroyed earlier this year in Fukushima, Japan. Zeolites have their limitations, though. Their pores are almost universally tiny, making it tough to use them as catalysts for large molecules. And they"re difficult to form into ultrathin membranes, which researchers would like to do to enable cheaper separations. But progress by numerous teams on zeolite synthesis this year gave this “mature” area of chemistry new life. Researchers in South Korea crafted a family of zeolites in which the usual network of small pores is surrounded by walls holed with larger voids. That combination of large and small pores should lead to catalysts for numerous large organic molecules. Labs in Spain and China produced related large- and small-pore zeolites by using a combination of inorganic and organic materials to guide the structures as they formed. Meanwhile, researchers in France and Germany discovered that, by carefully controlling growth conditions, they could form a large-pore zeolite without the need for the expensive organic compounds typically used to guide their architecture as they grow. The advance opens the way for cheaper catalysts. In yet another lab, researchers in Minnesota came up with a new route for making ultrathin zeolite membranes, which are likely to be useful as a wide variety of chemically selective filters. This surge of molecular wizardry provides a vivid reminder that the creativity of chemists keeps their field ever young. Related References and Web Sites
2011.12.23
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