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Explanation for the polymerized nucleic acid enzyme's abnormal activation found
KAIST’s Professor Park Hyun Kyu of the Department of Bio Chemical Engineering revealed on the 23rd of December 2010 that his team had successfully developed the technology that uses the metal ions to control the abnormal activation of nucleic acids’ enzymes and using this, created a logic gate, which is a core technology in the field of future bio electrons.
The polymerized nucleic acid enzyme works to increase the synthesis of DNA and kicks into action only when the target DNA and primers form complimentary pairs (A and T, C and G).
Professor Park broke the common conception and found that it is possible for none complimentary pairs like T-T and C-C to initiate the activation of the enzyme and thus increase the nucleic acid production, given that there are certain metal ions present.
What Professor Park realized is that the enzymes mistake the uncomplimentary T-T and C-C pairs (with stabilized structures due to the bonding with mercury and silver ions) as being complimentary base pairs. Professor Park described this phenomenon as the “illusionary polymerase activity.”
The research team developed a logic gate based on the “illusionary polymerase activity’ phenomenon.” The logic gate paves the way to the development of future bio electron needed for bio computers and high performance memories.
Professor Park commented, “The research is an advancement of the previous research carried on about metal ions and nucleic acid synthesis. Our research is the first attempt at merging the concepts of the two previously separately carried out researches and can be adapted for testing presence of metal ions and development of a new single nucleotide polymorphic gene analysis technology.”
Professor Park added that, “Our research is a great stride in the field of nano scale electron element research as the results made possible the formation of accurate logic gates through relatively cost efficient and simple system designs.”
On a side note, the research was funded by Korea Research Foundation (Chairman: Park Chan Mo) and was selected as the cover paper for the December issue of ‘Angewandte Chemie International Edition’.
2011.01.18 View 14961 -
Korea should find niche in space race, Korea Herald, December 20, 2010
A proud alumna of KAIST, Dr. Yi So-Yeon, who went to the International Space Station in the outer space for the first time as a Korean in 2009, had an interview with the Korea Herald. In the interview, she talks about her experience in working at the space station and her personal plans for the future as a researcher and astronaut. For the article, please click the link:
http://www.koreaherald.com/lifestyle/Detail.jsp?newsMLId=20101220000999
2010.12.21 View 13040 -
The KAIST & GIT team developed a power generation technology using bendable thin film nano-materials.
Figure description: Flexible thin film nanomaterials produce electricity.
Can a heart implanted micro robot operate permanently?
Can cell phones and tiny robots implanted in the heart operate permanently without having their batteries charged?
It might sound like science fiction, but these things seem to be possible in the near future. The team of Prof. Keon Jae Lee (KAIST, Dept. of Materials Science and Engineering) and Prof. Zhong Lin Wang (Georgia Institute of Technology, Dept. of Materials Science and Engineering) has developed new forms of highly efficient, flexible nanogenerator technology using the freely bendable piezoelectric ceramic thin film nano-materials that can convert tiny movements of the human body (such as heart beats and blood flow) into electrical energy.
The piezoelectric effect refers to voltage generation when pressure or bending strength is applied to piezoelectric materials. The ceramics, containing a perovskite structure, have a high piezoelectric efficiency. Until now, it has been very difficult to use these ceramic materials to fabricate flexible electronic systems due to their brittle property.
The research team, however, has succeeded in developing a bio-eco-friendly ceramic thin film nanogenerator that is freely bendable without breakdown.
Nanogenerator technology, a power generating system without wires or batteries, combines nanotechnology with piezoelectrics that can be used not only in personal mobile electronics but also in bio-implantable sensors or as an energy source for micro robots. Energy sources in nature (wind, vibration, and sound) and biomechanical forces produced by the human body (heart beats, blood flow, and muscle contraction/relaxation) can infinitely produce nonpolluting energy. (Nanogenerator produces electricity by external forces: http://www.youtube.com/watch?v=tvj0SsBqpBw)
Prof. Keon Jae Lee (KAIST) was involved in the first co-invention of “High Performance Flexible Single Crystal Electronics” during his PhD course at the University of Illinois at Urbana-Champaign. This nanogenerator technology, based on the previous invention, utilized the similar protocol of transferring ceramic thin film nano-materials on flexible substrates and produced voltage generation between electrodes.
Prof. Zhong Lin Wang (Georgia Tech, inventor of the nanogenerator) said, “This technology can be used to turn on an LED by slightly modifying circuits and operate touchable flexible displays. In addition, thin film nano-materials (‘barium titanate’) of this research have the property of both high efficiency and lead-free bio compatibility, which can be used in future medical applications.” This result is published in November online issue of ‘Nano Letters’ ACS journal.
<Video>
Youtube link: http://www.youtube.com/watch?v=tvj0SsBqpBw
Thin Film Nanogenerator produces electricity by external forces.
2010.11.23 View 18566 -
2010 International Presidential Forum was held successfully.
On October 11th, the 2010 International Presidential Forum on “The Role of the Research University in an S&T Dominated Era: Expectation & Delivery” was held successfully at the Westin Chosun Hotel in Seoul. The third International Presidential Forum to be held, participants of the 2010 Presidential Forum engaged in an in-depth discussion about the direction that research universities should take in the 21st Century.
On its opening, President Nam Pyo Suh delivered a congratulatory message saying, “This forum is a meaningful gathering where research universities will suggest role models and find ways research universities can contribute to the progress of mankind in this century.”
Following, Lee Ki Jun, CEO of the Korean Federation of Science and Technology Societies said, “The common goal of the world’s research universities is to solve the problems mankind is facing together. I believe that the discussion we will hold today at the forum will point to the future direction of research universities.”
“To produce next generation engineers meeting global standards, exchange and dual degree programs between universities must be strengthened,” said Lars Pallesen, President of the Technical University of Denmark. “Research universities must support the exchange between students beyond cultural and national borders to adapt to the global market.”
Ichiro Okura, Vice President of Tokyo Institute of Technology, presented on the “Asian Science and Technology Pioneering Institutes of Research and Education, ASPIRE.” ASPIRE is a community created by the coalition between science and technology universities in the Far East. Its purpose is to contribute to sustainable global growth by educating high-quality human resources and lead Asia’s technology innovation based on science and technology development.
“For research universities to solve today’s global issues, universities must create new ideas by performing fundamental studies and developing innovative technology. The financial resources of universities must be focused with choices based on results,” remarked President Suh.
Zaini Ujang, Vice-President of the Universiti Teknologi Malaysia stated that “the Malaysian government is planning on converting from a ‘labor-intensive economy’ to an ‘innovative leading economy’ with the goal of joining the advanced countries by 2020. In today’s science and technology era where innovative technology is necessary, research universities have an important role of developing the knowledge environmental system to lead the world economy.” Vice-President Ujang then explained what strategies Malaysian research universities devised in the innovative leading economy era to create research universities that bring creativity and innovation.
Tod A. Laursen, President of KUSTAR, said that “KUSTAR has a leading role in bringing science and technology and manpower necessary in converting the oil-centered economy of UAE to a knowledge-based economy. KUSTAR will continuously strengthen international cooperation to become not only the best engineering university in the Arab region but in the world.”
At this year’s forum, thirty international presidents and vice presidents from 24 universities in 15 countries including Georgia Tech, Technical University of Denmark, Technion-Israel Institute of Technology, University of Queensland, Tokyo University, Nanyang Technological University, University Teknologi Malaysia and Hong Kong Institute of Science and Technology along with forty national figures such as the presidents of Hanyang University and Handong Global University, governmental bureaucrats and representatives from national business and institutions participated.
2010.10.20 View 20388 -
The 5th KAIST President's Advisory Council Held
The 5th KAIST President’s Advisory Council (PAC) was held on October 13 at KAIST. At PAC, President Suh reported important present conditions and achievements of KAIST and introduced the ‘KAIST Vision 2025’ to members of the council which includes top national and international professionals of the Industry-University-Institute collaboration.
Additionally, six latest research assignments of KAIST were selected and presented to the PAC. President Suh also presented the Freshman Design Course, Renaissance Ph.D. Program, KAIST-KUSTAR Cooperation Program, and the visions of Neil Pappalardo Medical Center and received advice from the council.
Through PAC, KAIST receives various strategic advices to develop KAIST into a global science and technology university, direct and indirect support on the KAIST development fund collection, and support to create, maintain and develop cooperation relationships with national and international distinguished institutes linked to advisory council members.
International PAC council members include Donald C. W. Kim, CEO of AMKOR A&E; Neil Pappalardo, former MEDITECH CEO; John R. Holzrichter, President of the Fannie and John Hertz Foundation; Papken Der Torossian, CEO of Vistec Semiconductor Systems Group; Adnan Akay, Vice President of Bilkent University; Arden Bement, Director of the National Science Foundation (NSF); Tod Laursen, President of KUSTAR in the UAE; Lars Pallesen, President of the Technical University of Denmark and Hiroyuki Yoshikawa, former President of the University of Tokyo.
National PAC council members include Kim Woo Sik, President of the Creativity Engineering Institute; Jin Hyun Kim, Chairman of the Committee for the Establishment of the National Museum of Korean Contemporary History; Myung Ja Kim, President of the Green Korea 21 Forum; Lee Hee Gook, President of LG Siltron; Lyu keun Chul, Professor of Bauman Moscow State Technical University; Bo-Young Kang, President of Andong Medical Group; Kwon Oh-Gap, former Vice Minister of Science and Technology; Sang chun Lee, President of Korea Institute of Machinery & Materials; and Bae Soo Hoon, Director of the Museum of Contemporary Art, Korea.
2010.10.20 View 16979 -
International Workshop on EEWS 2010 was held.
On October 7 and 8th at Fusion Hall of KI Building, KAIST, the 2010 International Workshop on EEWS (Energy, Environment, Water, and Sustainability) was held.
The third to be held, forty national and international academic professionals including Mark Shannon, professor at University of Illinois at Urbana-Champaign, Domen Kazunari, Tokyo University professor, Dong Sub Kim, CTO of SK Energy and Doyoung Seung, Senior Vice President of GS Caltex, participated at this year’s workshop.
In twelve sessions, themes including Artificial Photosynthesis, Wireless Power Transfer, Green Aviation, Safe Nuclear Fuel Reuse, Fuel Cells in Action, LED 2.0, Foundation of Energy-Water Nexus, and Flexible Battery & Solar Cell were presented and discussed.
“Through this workshop, current EEWS policy and research progress from different countries and the future of related technologies will be foreseen,” said Jae Kyu Lee, Dean of KAIST EEWS Initiative. “I hope it became an opportunity to create cooperative relationships with leading researchers.”
EEWS is a research project conducted by KAIST to solve global issues that mankind faces today such as depletion of energy, environmental pollution, water shortage, and sustainability.
2010.10.15 View 20891
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The 9th International Conference on Entertainment Computing Held, Sep 8-11, 2010
The cyber world is no longer an unrealistic place for a contemporary man who spends most of his time in front of a computer nowadays. The entertainment contents industry, which materializes the cyber world, leads the new knowledge economy and is emerging as a new growth engine for high value-added industry.
Professionals in entertainment computing gathered to discuss how to make the cyber space more elaborate and entertaining. The 9th 2010 International Conference on Entertainment Computing (ICEC) was held from September 8 to September 11 at Seoul COEX by KAIST and International Federation for Information Processing (IFIP).
This year’s theme is “Creative and Innovative Science, Computing and Design for Digital and Entertainment Contents in 21C”, with fifteen global leaders of industry-university-institute collaboration speakers including George Joblove (Executive VP of Sony Pictures Technologies), Massimiliano Gasparri (VP of Warner Bros. Advanced Digital Services), Don Marinelli (Executive Producer of Entertainment Technology Center at University of Carnegie Mellon), Keith Devlin (Founding Executive Director of Stanford Media-X and Executive Director of Stanford H-STAR), Roy Ascott (President of Planetary Collegium).
Speeches, paper sessions, workshops, exhibitions on the high-tech digital entertainment industry including computer graphics, cyber reality, telepresence, 3D/4D, mobile games, animation, special effects, robot design, content production and distribution, media art were held at the conference this year.
This event was sponsored by IEEE, ACM, IPS, ADADA, Elsevier, ETRI, SK Telecom, KIISE, KMMS, HCI Korea, KCGS and KCGS.
2010.09.17 View 17149
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International Center was built to promote greater exchanges and collaborations between the international community and KAIST.
On July 9, 2010, KAIST held an opening ceremony for the construction of International Center. The Center will serve as an internal and external liaison for the university, providing a source of assistance to faculty, administrators, and students on matters related to international activities and initiatives. It will also pursue greater exchanges and collaborations between the international community and KAIST.
The facility accommodates various meetings, exhibitions, library, language services, and other amenities. The International Cooperation Team of KAIST will be moved into this building and provide a variety of services, such as immigration regulations, cultural adjustment, employment, to assist international students, scholars, faculty, and staff at KAIST, as well as Korean students seeking opportunities to study, work, or travel abroad. An international nursery school will also be inside the building so that foreign faculty and students with children can have convenience and quality child care while they are teaching or studying.
At the center will be held many different kinds of international event—one among them is KAIST-ONE, a festival held twice a year in spring and fall to introduce and share culture, education, and food of the global community at KAIST.
2010.07.19 View 14556 -
The 8th International Conference on Metabolic Engineering was held on June 13-18, 2010 in Jeju Island, South Korea.
From left to right, top row: Distinguished Professor and the conference chair Sang Yup Lee, Sang-Hyup Kim - Secretary to the President of Korea, Dr. Jay Keasling, Dr. Greg Stephanopoulos. Left to right, bottom row: Dr. William Provine, Dr. Terry Papoutsakis, Dr, Jens Nielsen, Dr. Lars Nielsen.
The importance of industrial biotechnology that produces chemicals and materials from renewable biomass is increasing due to climate change and the dearth of natural resources. Industrial biotechnology refers to a technology that allows sustainable bio-based production of chemicals and materials that could enrich human"s lives using microorganisms. This is where metabolic engineering comes into play for successful application of microorganisms, in which they are engineered in our intended way for improved production capability.
The 8th International Conference on Metabolic Engineering, the longest running conference of its kind, was held on June 13-18, 2010 at the International Convention Center in Jeju Island, South Korea. Distinguished Professor Sang Yup Lee of KAIST, Dean of College of Life Science and Bioengineering and Co-Director of Institute for the BioCentury, chaired the conference with the main theme of "metabolic engineering for green growth."
With 300 delegates selected by the committee, papers on production of biofuels, chemicals, biopolymers, and pharmaceutics and the development of fundamental metabolic engineering techniques were presented at the conference along with examples of successful commercialization of products developed by several global companies.
Sang Hyup Kim, Secretary to the President of Korea, gave an opening plenary lecture entitled "Korean green growth initiative," to inform experts from around the globe of the leadership on green growth in Korea. Young Hoon Park, President of Korea Research Institute of Bioscience and Biotechnology (KRIBB, Korea) delivered his congratulatory address.
Sang Hyup Kim said, "Hosting an international conference in Korea on metabolic engineering, which forms a core technology necessary for the development of environmentally friendly processes for producing chemicals and biofuels from renewable biomass, is very meaningful as green growth is a big issue around the globe. This is a great chance to show the excellence of Korea"s green growth associated technology to experts in metabolic engineering and industrial biotechnology."
A total of 47 invited lectures in this conference included recent and important topics, for instance, "Synthetic biology for synthetic fuels" by Dr. Jay Keasling from the Joint BioEnergy Institute (USA), "Microbial oil production from renewable feedstocks" by Dr. Greg Stephanopoulos from MIT (USA), "Yeast as a platform cell factory for production of fuels and chemicals" by Dr. Jens Nielsen from Chalmers University (Sweden), "Mammalian synthetic biology - from tools to therapies" by Dr. Martin Fussengger from ETH (Switzerland), "Building, modeling, and applications of metabolic and transcriptional regulatory networks at a genome-scale" by Dr. Bernhard Palsson from the University of California - San Diego (USA), "Genome analysis and engineering Eschericha coli for sucrose utilization" by Dr. Lars Nielsen from the University of Queensland (Australia), "Artificial microorganisms by synthetic biology" by Dr. Daniel Gibson from JCVI (USA), and "Metabolomics and its applications" by Dr. Masaru Tomita from Keio University (Japan). From Korea, Dr. Jin Hwan Park from the research group of Dr. Sang Yup Lee at KAIST presented "Systems metabolic engineering of Escherichia coli for amino acid production," and Dr. Ji Hyun Kim from KRIBB presented "Genome sequencing and omics systems analysis of the protein cell factory of Escherichia coli".
Global companies involved in biorefinery presented their recent research outcomes with emphasis on commercialized technologies. They included "Metabolic and process engineering for commercial outcomes" by Dr. William Provine from DuPont (USA), "Direct production of 1,4-butanediol from renewable feedstocks" by Dr. Mark Burk from Genomatica (USA), "Development of an economically sustainable bioprocess for the production of bio 1,2-propanediol" by Dr. Francis Voelker from Metabolic Explorer (France), "Biotechnology to the bottom-line: low pH lactic acid production at industrial scale" by Dr. Pirkko Suominen from Cargill (USA), "Bioisoprene™: traditional monomer, traditional chemistry, sustainable source" by Dr. Gregg Whited from Danisco (USA) and "Efficient production of pharmaceuticals by engineered fungi" by Dr. Roel Bovenberg from DSM (Netherlands).
This biennial conference also presented the International Metabolic Engineering Award (expanded version of the previous Merck Metabolic Engineering Award) to the best metabolic engineer in the world. The 2010 International Metabolic Engineering Award went to Dr. E. Terry Papoutsakis from the University of Delaware (USA) who has contributed to the production of biobutanol through the metabolic engineering of Clostridia in the last three decades, and he gave an award lecture. Dr. Sang Yup Lee, the current chair of the upcoming conference, was the previous recipient of this award at the last metabolic engineering conference in 2008.
In addition to the invited lectures, a total of 156 carefully selected poster papers were chosen for presentation, and awards were presented to the best posters after rigorous review by the committee members. Such awards included "The 2010 Metabolic Engineering Best Poster Award" and the "2010 Young Metabolic Engineer Award" from the Metabolic Engineering conference, and prestigious international journal awards, including "Wiley Biotechnology Journal Best Poster Award", "Wiley Biotechnology and Bioengineering Best Poster Award" and "Elsevier Metabolic Engineering Best Paper Award." Dr. Catherine Goodman, a senior editor of Nature Chemical Biology, also presented the "Nature Chemical Biology Best Poster Award on Metabolic Engineering."
Regarding this conference, Dr. Sang Yup Lee, the conference chair, said, "This conference is the best international conference in the field of metabolic engineering, which is held every two years, and Korea is the first Asian country to host it. All the experts and students spend time together from early breakfast to late poster sessions, which is a distinct feature of this conference. Although the number of delegates had typically been limited to 200, around 300 delegates were selected this year to accept more attendees from many people who have been interested in metabolic engineering. Also, it is very fitting that "green growth" is the main topic of this conference because Korea is playing a key role in this field. I"m grateful to the Lotte Scholarship Foundation, COFCO, GS Caltex, Bioneer, US DOE, US NSF, Daesang, CJ Cheiljedang, Genomatica and DuPont who provided us with generous financial support that allowed the successful organization of this conference."
The conference was organized by the Systems Biology Research Project Team supported by the Ministry of Eduction, Science and Technology (MEST), Microbial Frontier Research Project Group, World Class University Project Group at KAIST, Institute for the BioCentury at KAIST, Korean Society for Biotechnology and Bioengineering, and the Engineering Conference International (ECI) of the United States.
Inquiries: Professor Sang Yup Lee (+82-42-350-3930), industrialbio@gmail.com
2010.06.25 View 23205 -
The 2010 International Forum on Electric Vehicle will be held at the Korea Advanced Institute of Science and Technology (KAIST) in Daejeon, South Korea.
Universities, industries, and governments from the world gathered to make an important endeavor for the commercialization of electric vehicles that has emerged as a strong option to replace conventional cars with an internal combustion engine.
With the potential benefit of electric cars, in view of environmental protection and less dependence of oil import, they still have limitations for the daily use in customers’ perspective. Electric cars are still very expensive to own with relatively short distance of driving with one charging and with the expensive and bulky nature of the batteries, in addition to the safety concerns with the Lithium batteries.
The Korea Advanced Institute of Science and Technology (KAIST) will hold an international forum, at which it hopes to address a wide range of issues related to the development and commercialization of electric vehicles. The 2010 International Forum on Electric Vehicle will be held for three days at KAIST’s campus in Daejeon, South Korea, from June 17th to 19th, 2010.
Internationally renowned speakers from Korea and overseas will present their views and conduct a discussion forum on the technology, market, and policy on electric vehicles. The event is open to the public.
Major discussions, however, will take place on the second day, Friday, June 18, 2010, which will proceed with two sessions. In the first session, conference participants will discuss the topic of “policies and markets for electric vehicles,” and at the second session, they will take up the issue of “electric vehicle technologies.”
Dr. Andrew Brown, president of SAE International and the executive director and chief technologist of Delphi, is scheduled to give a key note speech. The SAE International is a global association of more than 128,000 engineers and related technical experts in the aerospace, automotive, and commercial vehicle industries.
Topics to be covered by Dr. Brown during his key note speech are, among other things, elements of market forces for hybrid electric vehicles, electric vehicles, or battery-powered vehicles; clean technologies necessary for sustainable development; pending issues facing the automotive industry to create a substantial share by electric cars and government aids to increase consumers’ buying power for expensive electric cars; technology innovation required for the improvement of batteries and power electronics; development of smart grids; and other key issues that would mature an ever-growing market for electric vehicles.
President Nam Pyo Suh of KAIST will also deliver a key note remark on the overall accomplishments of online electric vehicle (OLEV) developed by KAIST. While stressing the OLEV’s technological breakthrough to succeed in the wireless in-motion power transfer through electromagnetic induction, President Suh will review the necessity of developing electric cars as a corresponding measure against climate changes and address the issues of battery weight and lifespan, charging time, and the limited amount of reserved Lithium.
Dr. Steven Shladover from the California Partners for Advanced Transit and Highways (California PATH), established in 1986 in collaboration with the University of California in Berkeley and the California Transit, will attend the conference. California PATH is a multi-disciplinary program with universities statewide and cooperative projects with private industry, state and local agencies, and non-profit institutions to find solutions to the problems of California’s surface transportation systems through cutting edge research.
California PATH once implemented a bold, innovative research project in the early 1990s in order to overcome the most difficult technical hurdle to reduce the heavy dependence of batteries for electric cars by adopting a non-contact transfer of electric power during vehicles’ movement. Despite the research declared as “unsuccessful” by California PATH, the implications of their innovative approach to solve an important issue inspired many researches subsequently followed—one of them is KAIST’s OLEV project.
In addition, the Infineon Technologies AG, a leading semiconductor and system manufacturer based in Germany, which offers solutions for automotive, industrial and multimarket sectors for applications in communication and memory products, will come to the forum and present a paper on its expertise to develop the necessary components for electric vehicles.
On the last day of the forum, all participants will have a chance to ride the Online Electric Vehicle (OLEV) at KAIST’s campus.
For details of the event, please visit the website of “www.olev.co.kr/en/ifev or refer to the invitation attached herewith.
About KAIST’s Online Electric Vehicle:
The Online Electric Vehicle (OLEV) developed by KAIST is a dynamic plug-in electric car that receives electricity while running or stopping and thus acquired a complete mobility unlike other type of electric cars, whether hybrid or not. The OLEV reduces the size of a battery to one-fifth of the current battery installed in an electric car. Pure electric cars depend on a large bulky battery that has been a major obstacle to make the cars commercially accessible to the mass market. The OLEV gets charged wirelessly, a distinct difference to other dynamic plug-in electric cars including a tram or trolley, which directly picks up electricity from the road.
To explain it further, the OLEV is electrified through power lines buried underground; when flowing low frequency of currents, an electric magnetic field is created around the underground power lines, and the pick-up gadget installed underbody of an electric vehicle converts the field into electricity; and the vehicle then uses electricity either for operation or stores it at a battery to be used for running the road that is not equipped with the power lines. The electric power generated from the underground travels to the surface of the road above 20cm-25cm.
KAIST has succeeded to develop a commercial model of OLEV with a safe Electromagnetic Field (EMF), well below the international safeguard of 65mG. The actual model has been up and running at an amusement park in Seoul for the transportation of passengers. The non-contact charging method applied to the OLEV will accelerate the commercialization of electric cars by making a battery affordable and safer for a consumer.
2010.06.25 View 16410 -
New drug targeting method for microbial pathogens developed using in silico cell
A ripple effect is expected on the new antibacterial discovery using “in silico” cells
Featured as a journal cover paper of Molecular BioSystems
A research team of Distinguished Professor Sang Yup Lee at KAIST recently constructed an in silico cell of a microbial pathogen that is resistant to antibiotics and developed a new drug targeting method that could effectively disrupt the pathogen"s growth using the in silico cell.
Hyun Uk Kim, a graduate research assistant at the Department of Chemical and Biomolecular Engineering, KAIST, conducted this study as a part of his thesis research, and the study was featured as a journal cover paper in the February issue of Molecular BioSystems this year, published by The Royal Society of Chemistry based in Europe.
It was relatively easy to treat infectious microbes using antibiotics in the past. However, the overdose of antibiotics has caused pathogens to increase their resistance to various antibiotics, and it has become more difficult to cure infectious diseases these days.
A representative microbial pathogen is Acinetobacter baumannaii. Originally isolated from soils and water, this microorganism did not have resistance to antibiotics, and hence it was easy to eradicate them if infected. However, within a decade, this miroorganism has transformed into a dreadful super-bacterium resistant to antibiotics and caused many casualties among the U.S. and French soldiers who were injured from the recent Iraqi war and infected with Acinetobacter baumannaii.
Professor Lee’s group constructed an in silico cell of this A. baumannii by computationally collecting, integrating, and analyzing the biological information of the bacterium, scattered over various databases and literatures, in order to study this organism"s genomic features and system-wide metabolic characteristics. Furthermore, they employed this in silico cell for integrative approaches, including several network analysis and analysis of essential reactions and metabolites, to predict drug targets that effectively disrupt the pathogen"s growth. Final drug targets are the ones that selectively kill pathogens without harming human body.
Here, essential reactions refer to enzymatic reactions required for normal metabolic functioning in organisms, while essential metabolites indicate chemical compounds required in the metabolism for proper functioning, and their removal brings about the effect of simultaneously disrupting their associated enzymes that interact with them.
This study attempted to predict highly reliable drug targets by systematically scanning biological components, including metabolic genes, enzymatic reactions, that constitute an in silico cell in a short period of time.
This research achievement is highly regarded as it, for the first time, systematically scanned essential metabolites for the effective drug targets using the concept of systems biology, and paved the way for a new antibacterial discovery. This study is also expected to contribute to elucidating the infectious mechanism caused by pathogens.
"Although tons of genomic information is poured in at this moment, application research that efficiently converts this preliminary information into actually useful information is still lagged behind. In this regard, this study is meaningful in that medically useful information is generated from the genomic information of Acinetobacter baumannii," says Professor Lee. "In particular, development of this organism"s in silico cell allows generation of new knowledge regarding essential genes and enzymatic reactions under specific conditions," he added.
This study was supported by the Korean Systems Biology Project of the Ministry of Education, Science and Technology, and the patent for the development of in silico cells of microbial pathogens and drug targeting methods has been filed.
[Picture 1 Cells in silico]
[Picture 2 A process of generating drug targets without harming human body while effectively disrupting the growth of a pathogen, after predicting metabolites from in silico cells]
2010.04.05 View 21126
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Future of Electric Automobile Glimpsed from KAIST
Etnews.co.kr. printed an interview with Professor Edward A. Lee, from the Department of Electrical Engineering and Computer Sciences, University of California in Berkeley, who visited KAIST to attend the 2010 International Workshop on Information Technology (IT) Convergence. During the workshop, Professor Lee had a chance to ride KAIST’s Online Electric Vehicle (OLEV), and etnews.co.kr. asked him about his impressions.
Article published on Friday, February 19, 2010
(For the Korean article, please click the link at http://www.etnews.co.kr/news/detail.html?id=201002190158)
The below is a translation from the Korean text.
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Reported by Hee-Bum Park (hbpark@etnews.co.kr)
"Future of Electric Automobile Glimpsed from KAIST"s Online Electric Vehicle Project," said Professor Lee.
Distinguished Professor Edward A. Lee, from the Department of Electrical Engineering and Computer Sciences, University of California in Berkeley, expressed his impressions after a ride on KAIST’s Online Electric Vehicle.
“KAIST’s Online Electric Vehicle (OLEV) really grabs my attention because the vehicle receives its needed electricity from a cable buried underground, not from batteries. Still, many challenges lie ahead for the electric vehicle to be commercialized, but I think, today, I saw the future of electric vehicles from the KAIST project,” explained Professor Lee.
Professor Lee came to Daejeon to attend the “2010 International Workshop on Information Technology (IT) Convergence,” which was held on February 19, 2010 at KAIST’s Information and Communication Convergence (ICC) Campus.
“I rode the bus and saw its instrument panel, which displays figures of electricity picked up from the ground. The bus presents the possibility of an electric car that can actually be built in the near future,” added Professor Lee.
Professor Lee, however, pointed out that a number of issues should be addressed beforehand to commercialize OLEV, such as public concerns about magnetic waves, the economic impact of laying power strips underground, and battery efficiency as an alternative to petroleum based fuel. Nonetheless, he said that given people’s increased awareness of the problems associated with CO2 emissions, OLEV’s development is timely.
“As far as I know, there has been no research in the US to develop an electric car that receives electricity from cables buried beneath the road. It is creative and ambitious for KAIST to try to find the technological breakthrough necessary for the development of electric cars,” Professor Lee stated.
Professor Lee further commented, “So far, batteries on electric cars are heavy and bulky, and they require frequent recharging. I think KAIST has provided a solution to address this issue.”
Graduating from Yale University and Massachusetts Institute of Technology (MIT), Professor Lee earned his doctoral degree in Electrical Engineering and Computer Sciences from UC Berkeley. He worked for Bell Telephone Laboratories in Holmdel, New Jersey.
2010.03.03 View 16491