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Unlocking the Keys to Parkinson's Disease
A KAIST research team has identified a new mechanism that causes the hallmark symptoms of Parkinson’s disease, namely tremors, rigidity, and loss of voluntary movement.
The discovery, made in collaboration with Nanyang Technological University in Singapore, presents a new perspective to three decades of conventional wisdom in Parkinson’s disease research. It also opens up new avenues that can help alleviate the motor problems suffered by patients of the disease, which reportedly number more than 10 million worldwide. The research was published in Neuron on August 30.
The research team was led by Professor Daesoo Kim from the Department of Biological Sciences at KAIST and Professor George Augustine from the Lee Kong Chian School of Medicine at NTU. Dr. Jeongjin Kim, a former postdoctoral fellow at KAIST who now works at the Korea Institute of Science and Technology (KIST), is the lead author.
It is known that Parkinson’s disease is caused by a lack of dopamine, a chemical in the brain that transmits neural signals. However, it remains unknown how the disease causes the motor
Smooth, voluntary movements, such as reaching for a cup of coffee, are controlled by the basal ganglia, which issue instructions via neurons (nerve cells that process and transmit information in the brain) in the thalamus to the cortex. These instructions come in two types: one that triggers a response (excitatory signals) and the other that suppresses a response (inhibitory signals). Proper balance between the two controls movement.
A low level of dopamine causes the basal ganglia to severely inhibit target neurons in the thalamus, called an inhibition. Scientists have long assumed that this stronger inhibition causes the motor problems of Parkinson’s disease patients.
To test this assumption, the research team used optogenetic technology in an animal model to study the effects of this increased inhibition of the thalamus and ultimately movement. Optogenetics is the use of light to control the activity of specific types of neurons within the brain.
They found that when signals from the basal ganglia are more strongly activated by light, the target neurons in the thalamus paradoxically became hyperactive. Called rebound excitation, this hyperactivity produced abnormal muscular stiffness and tremor. Such motor problems are very similar to the symptoms of Parkinson’s disease patients. When this hyperactivity of thalamic neurons is suppressed by light, mice show normal movments without Parkinson’s disease symptoms. Reducing the levels of activity back to normal caused the motor symptoms to stop, proving that the hyperactivity caused the motor problems experienced by Parkinson’s disease patients.
Professor Kim at KAIST said, “This study overturns three decades of consensus on the provenance of Parkinsonian symptoms.” The lead author, Dr Jeongjin Kim said, “The therapeutic implications of this study for the treatment of Parkinsonian symptoms are profound. It may soon become possible to remedy movement disorders without using L-DOPA, a pre-cursor to dopamine.”
Professor Augustine at NTU added, “Our findings are a breakthrough, both for understanding how the brain normally controls the movement of our body and how this control goes awry during Parkinson’s disease and related dopamine-deficiency disorders.”
The study took five years to complete, and includes researchers from the Department of Bio & Brain Engineering at KAIST.
The research team will move forward by investigating how hyperactivity in neurons in the thalamus leads to abnormal movement, as well as developing therapeutic strategies for the disease by targeting this neural mechanism.
Figure abstract: Inhibitory inputs from the basal ganglia inhibit thalamic neurons (upper). In low-dopamine states, like PD, rebound firing follows inhibition and causes movement disorders (middle). The inhibition of rebound firing alleviates PD-like symptoms in a mouse model of PD.
2017.09.22 View 9481 -
Draining Eyes Clogged with Glaucoma
Professor Gou Young Koh in the Graduate School of Medical Science and Engineering and his team have identified a new mechanism involved in the development and progression of glaucoma, and found a potential therapeutic option to treat it. Glaucoma is the second cause of irreversible blindness, after cataracts. It affects about 3.5% of the world population aged 40 to 80.
Professor Koh also serves as the director of the Center for Vascular Research at the Institute for Basic Science. The IBS said the study, published in the Journal of Clinical Investigation, is expected to help the development of therapies to treat primary open-angle glaucoma (POAG), which counts for three quarters of all glaucoma patients.
One of the most important risk factors for glaucoma is the increased pressure inside the eye. A liquid called aqueous humor is constantly produced and drained out from the eye. It transports nutrients and inflates the eye giving it a roughly spherical shape. However, if this fluid cannot flow out of the eye chambers freely, an increase in intraocular pressure can damage the optic nerve, leading to vision loss. The precise mechanism of elevated resistance to aqueous humor outflow remains unclear, and although the current treatments for glaucoma tackle the production and outflow of aqueous humor, their outcomes are still poor.
A component of the eye that plays a fundamental role in draining out the aqueous humor is Schlemm's canal. It collects the aqueous humor and mediates its transfer from the eye chambers to blood circulation. The cells on the walls of the canal, endothelial cells, ship the liquid from the inner to the outer side in “packages”, called vacuoles. As the shape and number of the vacuoles reflects the outflow performance, several giant vacuoles are expected in the normal outflow process.
The team explained how imbalances in Schlemm's canal significantly increase the risk of glaucoma. They showed that an important regulator for canal functionality is the angiopoietin-Tie2 system. Angiopoietins, such as Ang1 and Ang2, are proteins important for the growth of new blood vessels and Tie2 is the receptor that binds them. It is known that the angiopoietin-Tie2 system plays a role in Schlemm’s canal formation, as Tie2 mutations or angiopoietin absence result in congenital glaucoma. However, this study clarified that it is also critically important during adulthood.
The researchers reported that adult mice deficient in Tie2 suffer from an elevated intraocular pressure, retinal neuronal damage and partial visual impairment. Moreover, they had a markedly decreased number of giant vacuoles inside Schlemm’s canal endothelial cells, which indicate a poor aqueous humor drainage.
The scientists also investigated if and how this process changes in older mice, as aging is a major risk factor for glaucoma, and showed that aged mice experience reduced levels of giant vacuoles, Tie2, Ang1, and Ang2, as well as other proteins connected with the angiopoietin-Tie2 pathway, like Prox1.
To test whether Tie2 activation could shift the situation, the researchers tested the antibody ABTAA (Ang2-binding and Tie2-activating antibody). They injected it in one eye of mice, while the other eye of the same mice functioned as the negative control. After one week, levels of Tie2 and Prox1, number and diameter of giant vacuoles in Schlemm’s canals increased in the ABTAA-treated eyes compared to control eyes. The researchers observed a similar outcome with decreased intraocular pressure when ABTAA was injected to the eyes of mice suffering from POAG with regressed Schlemm’s canals, indicating that this antibody might be considered as a therapeutic option.
"Slow development of glaucoma treatments is partly due to the poor understanding of the underlying pathogenesis," said Professor Koh, the corresponding author of the study. "We hope that identifying the critical role of the angiopoietin-Tie2 system in adult Schlemm’s canals will bring a significant boost in the development of therapeutics."
Figure 1: Schlemm's canal position inside the eye.
Schlemm's canal (green) plays a fundamental role in draining the aqueous humor (white arrows) from the anterior chamber of the eye to blood circulation. If the aqueous humor is not able to flow out freely, elevated intraocular pressure damages the optical nerve causing glaucoma and eventually blindness.
Figure 2: Electron microscope images reveal how the aqueous humor is packaged in vacuoles (arrowheads) inside the cells forming the walls of Schlemm's canal.
Aging and glaucoma cause the number and size of giant vacuoles to decrease, meaning that the aqueous humor outflow is compromised. The images compare the giant vacuoles in Schlemm's canals of a healthy mouse (top) and a mouse lacking Tie2 (bottom)
Figure 3: The Ang2-binding and Tie2-activating antibody (ABTAA) rejuvenates the eye of aged mice and rescues them from glaucoma.
Aging causes a reduction of the protein Tie2, a risk factor for increased intraocular pressure and glaucoma. In this experiment, one eye of mice lacking Ang1 and Ang2 was injected with the premixed ABTAA and Ang2, while the other eye was used as negative control. The researchers observed an increase in the area of Schlemm’s canal, together with higher levels of Tie2 (red) and lower intraocular pressure, suggesting that ABTAA restores the canal's functionality. The image includes the transcription factor Prox1 (green) and CD144 (blue), a protein present at the junctions between cells that form the wall of the canal. The angiopoietin-Tie2 system and Prox1 are linked by a vicious circle: the less Tie2 and Ang2, the less Prox1, leading to Schlemm's canal damage, increase in intraocular pressure, and acceleration of glaucoma progression.
2017.09.19 View 6664 -
Professor Jun Ho Oh's Total Solar Eclipse Featured in the APOD, NASA
(Professor Jun Ho Oh)
A video of a total solar eclipse, filmed in Warm Springs, Oregon by Professor Jun Ho Oh of the Department of Mechanical Engineering, was selected as the Astronomy Picture of the Day (APOD).
APOD, is a NASA website specializing in astronomy pictures. It features astronomical observations recorded by the Hubble Space Telescope or photos taken by astronomical observers from around the world.
Professor Oh is now the second Korean and the first amateur photographer whose photo was selected as the APOD.
According to the website, ‘the video frames were acquired with equipment specifically designed by Jun Ho Oh to track a close-up of the Sun’s periphery during the eclipse.’
Also, Digital Photography Review (dpreview.com) introduced observation points of the eclipse in his three-minute video, including solar prominences, corona, and Baily’s beads.
Professor Oh, the creator of the bipedal walking humanoid robot named Hubo, has been chasing eclipse since his first trip to Turkey in 1999.
“After numerous trials and failures over the last 18 years, I was finally able to capture every single breath-taking moment of the total eclipse,” said the professor.
He’s already planning for the next total eclipse in Chile on July 2, 2019.
Click the link to watch the video https://apod.nasa.gov/apod/ap170912.html
(#1 Photo of solar eclipse)
(#2 Photo of solar eclipse)
2017.09.14 View 5887 -
Humicotta Wins the Silver Prize at the 2017 IDEA
The 3D-printed ceramic humidifier made by the research team led by Professor Sang-Min Bae won the silver prize at the 2017 International Design Excellence Awards (IDEA). Professor Bae’s ID+IM team was also listed as winners of three more appropriate technology designs at the IDEA. The awards, sponsored by the Industrial Designers Society of America, are one of the three prestigious design awards including the Red Dot Design Award and the iF Design Award in Germany.
The silver prize winner in the category of home and bath, Humicotta is an energy-efficient, bacteria free, and easy to clean humidifier. It includes a base module and filter. The base is a cylindrical pedestal with a built-in fan on which the filter is placed. The filter is a 3D-printed honeycomb structure made of diatomite. When water is added, the honeycomb structure and porous terracotta maximize natural humidification. It also offers an open platform service that customizes the filters or provides files that users can use their own 3D printer.
Professor Bae’s team has worked on philanthropy design using appropriate technology as their main topic for years. Their designs have been recognized at prestigious global design awards events, winning more than 50 prizes with innovative designs made for addressing various global and social problems.
The Light Funnel is a novel type of lighting device designed for off-grid areas of Africa. It helps to maximize the natural light effect in the daytime without any drastic home renovations. It consists of a transparent acrylic sphere and a reflective pathway. After filling the acrylic sphere with water and placing it on a rooftop, sunlight passes into the house through the water inside the sphere. It provides a lighted environment nine times brighter than without it. Also, once installed, it can be used almost permanently.
The Maasai Smart Cane is made using wood sticks purchased through fair trade with the Maasai tribe. GPS is installed into the grip of the birch-tree cane, so that cane users can send a signal when in an emergency situation. All of the proceeds of this product go to the tribe.
S.Cone is a first aid kit made in collaboration with Samsung Fire and Marine Insurance. The traffic cone-shaped kit is designed to help users handle an emergency situation intact and safe. The S.Cone has unique versions for fires, car accidents, and marine accidents. For example, the S.Cone for fires is equipped with a small fire extinguisher, smoke mask, and fire blanket. The cap of the S.Cone also functions as an IoT station connecting the fire and gas detector with smart phones.
Professor Bae said of his team’s winning design products, “By making the data public, any person can design their own humidifier if they have access to a 3D-printer. We want it to be a very accessible product for the public. The Light Funnel and Maasai Smart Cane are designed for economically-marginalized populations and the elderly. We will continue to make the best designed products serving the marginalized 90% of the population around the world.”
2017.09.14 View 23213 -
A Novel and Practical Fab-route for Superomniphobic Liquid-free Surfaces
(clockwise from left: Jaeho Choi, Hee Tak Kim, Shin-Hyun Kim)
A joint research team led by Professor Hee Tak Kim and Shin-Hyun Kim in the Department of Chemical and Biomolecular Engineering at KAIST developed a fabrication technology that can inexpensively produce surfaces capable of repelling liquids, including water and oil.
The team used the photofluidization of azobenzene molecule-containing polymers to generate a superomniphobic surface which can be applied for developing stain-free fabrics, non-biofouling medical tubing, and corrosion-free surfaces.
Mushroom-shaped surface textures, also called doubly re-entrant structures, are known to be the most effective surface structure that enhances resistance against liquid invasion, thereby exhibiting superior superomniphobic property.
However, the existing procedures for their fabrication are highly delicate, time-consuming, and costly. Moreover, the materials required for the fabrication are restricted to an inflexible and expensive silicon wafer, which limits the practical use of the surface.
To overcome such limitations, the research team used a different approach to fabricate the re-entrant structures called localized photofludization by using the peculiar optical phenomenon of azobenzene molecule-containing polymers (referred to as azopolymers). It is a phenomenon where an azopolymer becomes fluidized under irradiation, and the fluidization takes place locally within the thin surface layer of the azopolymer.
With this novel approach, the team facilitated the localized photofluidization in the top surface layer of azopolymer cylindrical posts, successfully reconfiguring the cylindrical posts to doubly re-entrant geometry while the fluidized thin top surface of an azopolymer is flowing down.
The structure developed by the team exhibits a superior superomniphobic property even for liquids infiltrating the surface immediately.
Moreover, the superomniphobic property can be maintained on a curved target surface because its surficial materials are based on high molecules.
Furthermore, the fabrication procedure of the structure is highly reproducible and scalable, providing a practical route to creating robust omniphobic surfaces.
Professor Hee Tak Kim said, “Not only does the novel photo-fluidization technology in this study produce superior superomniphobic surfaces, but it also possesses many practical advantages in terms of fab-procedures and material flexibility; therefore, it could greatly contribute to real uses in diverse applications.”
Professor Shin-Hyun Kim added, “The designed doubly re-entrant geometry in this study was inspired by the skin structure of springtails, insects dwelling in soil that breathe through their skin. As I carried out this research, I once again realized that humans can learn from nature to create new engineering designs.”
The paper (Jaeho Choi as a first author) was published in ACS Nano, an international journal for Nano-technology, in August.
(Schematic diagram of mushroom-shaped structure fabrication)
(SEM image of mushroom-shaped structure)
(Image of superomniphobic property of different types of liquid)
2017.09.08 View 7051 -
KAIST to Open the Meditation Research Center
KAIST announced that it will open its Meditation Research Center next June. The center will serve as a place for the wellness of KAIST community as well as for furthering the cognitive sciences and its relevant convergence studies.
For facilitating the center, KAIST signed an MOU with the Foundation Academia Platonica in Seoul, an academy working for enriching the humanities and insight meditation on Aug.31. The Venerable Misan, a Buddhist monk well-known for his ‘Heart Smile Meditation’ program, will head the center.
The center will also conduct convergence research on meditation, which will translate into brain imaging, cognitive behavior, and its psychological effects. Built upon the research, the center expects to publish textbooks on meditation and will distribute them to the public and schools in an effort to widely disseminate the benefits of meditation.
As mindful meditation has become mainstream and more extensively studied, growing evidence suggests multiple psychological and physical benefits of these mindfulness exercises as well as for similar practices. Mind-body practices like meditation have been shown to reduce the body’s stress response by strengthening the relaxation response and lowering stress hormones.
The Venerable Misan, a Ph.D in philosophy from Oxford University, also serves as the director of the Sangdo Meditation Center and a professor at Joong-Ang Sangha University, a higher educational institution for Buddhist monks.
Monk Misan said that meditation will play a crucial part in educating creative students with an empathetic mindset. He added, “Hi-tech companies in Silicon Valley such as Google and Intel have long introduced meditation programs for stress management. Such practices will enhance the wellness of employees as well as their working efficiency.”
President Sung-Chul Shin said of the opening of the center, “From long ago, many universities in foreign countries including Havard, Stanford, Oxfor universities and the Max Planck Institute in Germany have applied scientific approaches to meditation and installed meditation centers. I am pleased to open our own center next year and I believe that it will bring more diverse opportunities for advancing convergent studies in AI and cognitive sciences.
2017.08.31 View 5469 -
Professor Dan Keun Sung Endows Scholarship in Honor of His Retirement
Professor Dan Keun Sung in the School of Electrical Engineering contributed a 100 million KRW scholarship fund this month to KAIST to mark his retirement after more than three decades of work.
“As my retirement date comes closer, I have been thinking about what I could do for the school. I wanted to leave something behind, even though it’s small, for my lifelong school and students. I am hoping that this scholarship fund will benefit the members of KAIST.”
This isn’t his first time making a donation to KAIST. In 2013, Professor Sung donated ten million KRW, which was his cash prize from the 9th Haedong Academic Award of The Korean Institute of Communications and Information Sciences (KICS). At that time, Professor Sung had the chance to create a scholarship fund in his name; however, he wanted to highlight that the scholarship fund was for ‘someone,’ not created by ‘someone.’ In that sense, his scholarship fund was created with no name to benefit students in the School of Electrical Engineering. His colleagues and students supported his idea. Professor Seonghwan Cho, students, and alumni also participated in fund raising efforts, which reached 55 million KRW in total.
Professor Sung emphasized, “Donations should always be remembered, no matter how small they are.” He then explained his purpose for creating the scholarship fund by saying, “Fundraising can be truly meaningful to contributors, knowing that their money is going to supporting the school and students.”
Professor Sung, a fellow of the Institute of Electrical and Electronics Engineers (IEEE) Communication Society, started his post at KAIST in 1986. For the past 30 years, he has devoted himself to fostering young scholars and studying in the area of information and communication. He also participated in developing technologies for the resource management of various future cellular components, such as satellites, switchboards, and signaling networks.
2017.08.11 View 7947 -
Innovative Nanosensor for Disease Diagnosis
(Figure 1. Sensing Device)
(Figure 2. Protein templating route)
Breath pattern recognition is a futuristic diagnostic platform. Simple characterizing target gas concentrations of human exhaled breath will lead to diagnose of the disease as well as physical condition.
A research group under Prof. Il-Doo Kim in the Department of Materials Science has developed diagnostic sensors using protein-encapsulated nanocatalysts, which can diagnose certain diseases by analyzing human exhaled breath. This technology enables early monitoring of various diseases through pattern recognition of biomarker gases related to diseases in human exhalation.
The protein-templated catalyst synthesis route is very simple and versatile for producing not only a single component of catalytic nanoparticles, but also diverse heterogeneous intermetallic catalysts with sizes less than 3 nm. The research team has developed ever more sensitive and selective chemiresistive sensors that can potentially diagnose specific diseases by analyzing exhaled breath gases.
The results of this study, which were contributed by Dr. Sang-Joon Kim and Dr. Seon-Jin Choi as first authors were selected as the cover-featured article in the July issue of 'Accounts of Chemical Research,' an international journal of the American Chemical Society.
In human breath, diverse components are found including water vapor, hydrogen, acetone, toluene, ammonia, hydrogen sulfide, and carbon monoxide, which are more excessively exhaled from patients. Some of these components are closely related to diseases such as asthma, lung cancer, type 1 diabetes mellitus, and halitosis.
Breath analysis for disease diagnosis started from capturing exhaled breaths in a Tedlar bag and subsequently the captured breath gases were injected into a miniaturized sensor system, similar to an alcohol detector. It is possible to analyze exhaled breath very rapidly with a simple analyzing process. The breath analysis can detect trace changes in exhaled breath components, which contribute to early diagnosis of diseases.
However, technological advances are needed to accurately analyze gases in the breath, which occur at very low levels, from 1 ppb to 1 ppm. In particular, it has been a critical challenge for chemiresistive type chemical sensors to selectively detect specific biomarkers in thousands of interfering gases including humid vapor.
Conventionally, noble metallic catalysts such as platinum and palladium have been functionalized onto metal oxide sensing layers. However, the gas sensitivity was not enough to detect ppb-levels of biomarker species in exhaled breath.
To overcome the current limitations, the research team utilized nanoscale protein (apoferritin) in animals as sacrificial templates. The protein templates possess hollow nanocages at the core site and various alloy catalytic nanoparticles can be encapsulated inside the protein nanocages.
The protein nanocages are advantageous because a nearly unlimited number of material compositions in the periodic table can be assembled for the synthesis of heterogeneous catalytic nanoparticles. In addition, intermetallic nanocatalysts with a controlled atomic ratio of two different elements can be achieved using the protein nanocages, which is an innovative strategy for finding new types of catalysts. For example, highly efficient platinum-based catalysts can be synthesized, such as platinum-palladium (PtPd), platinum-nickel (PtNi), platinum-ruthenium (PtRu), and platinum-yttrium (PtY).
The research team developed outstanding sensing layers consisting of metal oxide nanofibers functionalized by the heterogeneous catalysts with large and highly-porous surface areas, which are especially optimized for selective detection of specific biomarkers. The biomarker sensing performance was improved approximately 3~4-fold as compared to the conventional single component of platinum and palladium catalysts-loaded nanofiber sensors. In particular, 100-fold resistance transitions toward acetone (1 ppm) and hydrogen sulfide (1 ppm) were observed in exhaled breath sensors using the heterogeneous nanocatalysts, which is the best performance ever reported in literature.
The research team developed a disease diagnosis platform that recognizes individual breathing patterns by using a multiple sensor array system with diverse sensing layers and heterogeneous catalysts, so that the people can easily identify health abnormalities. Using a 16-sensor array system, physical conditions can be continuously monitored by analyzing concentration changes of biomarkers in exhaled breath gases.
Prof. Kim said, “New types of heterogeneous nanocatalysts were synthesized using protein templates with sizes around 2 nm and functionalized on various metal oxide nanofiber sensing layers. The established sensing libraries can detect biomarker species with high sensitivity and selectivity.” He added, “the new and innovative breath gas analysis platform will be very helpful for reducing medical expenditures and continuous monitoring of physical conditions”
Patents related to this technology were licensed to two companies in March and June this year.
2017.07.19 View 9934 -
Professor Nam Jin Cho Selected as the Eugene P. Wigner Reactor Physicist Awardee
Professor Nam Jin Cho from the Department of Nuclear & Quantum Engineering was selected as the recipient of the 2017 ‘Eugene P. Wigner Reactor Physicist Award.’ The award, established in 1990 by the American Nuclear Society, honors individuals who have made outstanding contributions to the advancement of the field of reactor physics. The award is named after the late Eugene P. Wigner, a pioneer who helped nurture the nuclear age to technical maturity with his pioneering leadership in reactor design.
Professor Cho was recognized for his outstanding leadership and achievement in the field of nuclear physics, especially with his original research in analytic function expansion nodal methods, coarse-mesh angular dependent rebalance methods, and neutron transport calculations. A fellow of the ANS, Professor Cho is the first awardee from the Asian region.
Professor Cho gave all the credit to his colleagues and students at KAIST who have spared no effort while working together for three decades. “I am very grateful for the unique academic ambience which made this challenging work possible as well as the government’s continuing funding at the National Research Laboratory project.
2017.07.12 View 6122 -
Professor Poong Hyun Seong Selected as Fellow of the ANS
Professor Poong Hyun Seong of the Department of Nuclear and Quantum Engineering was selected as a fellow of the American Nuclear Society.
The selection was announced at their annual meeting held in San Francisco on June 12, in recognition of Professor Seong's contributions to the field of nuclear instrumentation, control andhuman factors engineering.
Founded in 1954, the American Nuclear Society selects scholars who have made outstanding achievements and contributions to the development of the nuclear engineering field each year.
Professor Seong's researches in the field of nuclear instrumentation, control and human factors engineering have contributed to the safe operation of nuclear power plants, to the development of systems to maintain nuclear power plants safely in the event of emergency and to the enhancement of effective response capabilities of nuclear power plant operators. His researches significantly contributed to the safety improvement of nuclear power plants and have been recognized worldwide.
Professor Seong said, "Korea has emerged as a nuclear powerhouse. I think not only my academic career but our national reputation in the field of nuclear research has been well recognized by our global peers.” Professor Seong has served as president of the Korean Nuclear Society, editor in chief of Nuclear Engineering and Technology, and as a commissioner of the Korean Nuclear Safety Commission. He is currently working as a commissioner of the Korean Atomic Energy Commission.
2017.06.29 View 6468 -
2017 World Friends ICT KAIST Sets Off to Ethiopia, Tanzania
KAIST launched the ‘2017 World Friends ICT KAIST’ on 21 June at a ceremony held at the Faculty Club. The event was attended by 40 student volunteers and faculty members including President Sung-Chul Shin and student volunteers.
The ‘2017 World Friends ICT KAIST’ is an oversees volunteer program aimed at providing ICT education for students from developing countries and for cultural exchange. The program was organized by the KAIST Leadership Center and sponsored by the National Information Agency (NIA) since 2015.
President Sung-Chul Shin delivered words of encouragement to start the opening ceremony, followed by an oath-taking by the volunteer group, safety training, and a commemorative photoshoot. This year’s World Friends ICT volunteer group consisted of 32 students and 2 staff members to lead and to support the team.
The group was divided into eight teams including APP-frica, KAI-Tigers, and WITH (4 members per team) to volunteer in Addis Ababa Institute of Technology (AAIT) and Adama Science and Technology University in Ethiopia (ASTU), as well as Nelson Mandela African Institute of Science and Technology (NM-AIST) in Tanzania. The teams will educate local students on ICT and promote cultural exchanges. The volunteer period is from July 7 to August 5, lasting about a month.
KAIST conducted primary document examinations and interviews from April 27 to May 18 on volunteer candidates who registered to take part, and selected 32 student volunteers. A total of 68 students registered to volunteer, resulting in a 1:2.1 competition rate.
The volunteering program was customized to the local needs of Ethiopia and Tanzania and thus consisted of ICT education, cultural exchanges, volunteering at farms on the weekends, and science experiments. The area with the most focus by the volunteer team is ICT education, which accounts for 70% of the total volunteer activities. The aim is to educate Ethiopian students at AAIT and ASTU on Windows, MS Office, Adobe Photoshop, and using smartphones. In Tanzania, the team is to volunteer with students of NM-AIST to provide ICT application education such as water tank control using appropriate technology and Arduino to local high school students.
The team is also planning to promote cultural exchanges by preparing K-Pop dancing, traditional Korean games such as Korean shuttlecock game (jegichagi) and Korean wrestling (ssireum), traditional cooking such as bibimbab and half-moon-shaped rice cake (songpyeon), and teaching the Korean language, as well as preparing cultural performances with local university students. On the weekends, the team will visit local farms to volunteer, and local elementary schools and orphanages to conduct science experiments for children, as well as physical education and art activities.
(Photo caption: Volunteers poses with faculty and staff members including President Sung-Chul Shin at a ceremony on June 21.)
2017.06.29 View 9619 -
Top 10 Emerging Technologies of 2017
The World Economic Forum’s Expert Network and Global Future Councils in collaboration with Scientific American and its Board of Advisors announced the top 10 emerging technologies of 2017 on June 26 in Dalian, China where the 2017 Summer Davos Forum is being held. Each technology was chosen for its potential to improve lives, transform industries, and safeguard the planet.
The KAIST delegation, headed by President Sung-Chul Shin, is participating in the forum’s diverse activities including IdeasLab and GULF (Global University Leaders Forum). KAIST is the only Korean representative participating in the IdeasLab. KAIST Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering, director of KAIST Institute, has served as a committee member of the Global Agenda Council on Emerging Technologies since 2012 and Global Future Council on the Fourth Industrial Revolution. He also chairs the Global Future Council on Biotechnologies.
Professor Lee said, “Very diverse technological breakthroughs were proposed for the final list of candidates. We made the final selections through very in-depth discussion with experts in each field.
We focused on the technologies which have a level of maturity that will enable them to be adopted widely within three to five years."
The top 10 emerging technologies are
(courtesy from https://
www.weforum.org/agenda/2017/06/these-are-the-top-10-emerging-technologies-of-2017):
2017 10대 기술.
1. Liquid biopsies
Liquid biopsies mark a step forward in the fight against cancer. First, they are an alternative where traditional tissue-based biopsies are not possible. Second, they provide a full spectrum of information compared to tissue samples, which only reflect the information available in the sample. Lastly, by homing in on circulating-tumor DNA (ctDNA), genetic material that routinely finds its way from cancer cells into the bloodstream, disease progression or resistance to treatment can be spotted much faster than otherwise relying on symptoms or imaging.
2. Harvesting clean water from air
The ability to extract clean water from air is not new, however existing techniques require high moisture levels and a lot of electricity. This is changing. A team from MIT and University of California, Berkeley has successfully tested a process using porous crystals that convert the water using no energy at all.
3. Deep learning for visual tasks
Computers are beginning to recognize images better than humans. Thanks to deep learning, an emerging field of artificial intelligence, computer-vision technologies are increasingly being used in applications as diverse as driving autonomous vehicles, medical diagnostics, damage assessment for insurance claims, and monitoring water levels and crop yield.
4. Liquid fuels from sunshine
Can we mimic the humble leaf to create artificial photosynthesis to generate and store energy? The prospects are looking increasingly positive. The answer lies in using sunlight-activated catalysts to split water molecules into water and hydrogen, and then using the same hydrogen to convert CO2 into hydrocarbons.
5. The Human Cell Atlas
An international collaboration aimed at deciphering the human body, called the Human Cell Atlas, was launched in October 2016. The project aims to identify every cell type in every tissue; learn exactly which genes, proteins, and other molecules are active in each type, and the processes which control that activity.
6. Precision farming
The Fourth Industrial Revolution is providing farmers with a new set of tools to boost crop yield and quality while reducing water and chemical use. Sensors, robots, GPS, mapping tools, and data-analytics software are all being used to customize the care that plants need.
7. Affordable catalysts for green vehicles
Progress is being made on a promising zero-emission technology, the hydrogen-fed fuel cell. Progress to date has been stymied by the high price of catalysts which contain platinum. However, much progress has been made in reducing reliance on this rare and expensive metal, and the latest developments involve catalysts that include no platinum, or in some cases no metal at all.
8. Genomic vaccines
Vaccines based on genes are superior to more conventional ones in a number of ways. They are faster to manufacture, which is crucial during violent outbreaks. Compared to manufacturing proteins in cell cultures or eggs, producing genetic material should also be simpler and less expensive.
9. Sustainable design of communities
Applying green construction to multiple buildings at once has the potential to revolutionize the amount of energy and water we consume. Sending locally-generated solar power to a smart microgrid could reduce electricity consumption by half and reduce carbon emissions to zero if a project currently under development at the University of California at Berkeley goes according to plan.
10. Quantum computing
Quantum computers’ almost limitless potential has only ever been matched by the difficulty and cost of their construction. This explains why today the small ones that have been built have not yet managed to exceed the power of supercomputers. But progress is being made and in 2016 the technology firm IBM provided public access to the first quantum computer in the cloud.
2017.06.28 View 11558