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Prof. Cho Identifies Dynamics of Signal Transportation System in Control of Cell Proliferation
KAIST, Jan. 22, 2009 -- A research team led by Prof. Kwang-Hyun Cho of the Department of Bio and Brain Engineering, KAIST, has identified a hidden mechanism of the dynamic behavior of signal transportation system involved in the control of cell proliferation, university authorities said.
The finding is expected to provide a clue to appropriately controlling the pathway of ERK protein which is known to play a significant role in causing and spreading cancer. The research was featured as the cover paper of the latest online edition of the Journal of Cell Science.
The Ras-Raf-MEK-ERK pathway (or ERK pathway) is an important signal transduction system involved in the control of cell proliferation, survival and differentiation. However, the dynamic regulation of the pathway by positive- and negative-feedback mechanism, in particular the functional role of Raf kinase inhibitor protein (RKIP) are still incompletely understood. RKIP is a physiological endogenous inhibitor of MEK phosphorylation by Raf kinases, but also participates in a positive-feedback loop in which ERK can inactivate RKIP.
"We attempted to unearth the hidden dynamics of these feedback mechanisms and to identify the functional role of RKIP through combined efforts of biochemical experiments and computer simulations based on an experimentally validated mechanical model," Prof. Cho was quoted as saying.
2009.02.03 View 11087 -
Six Organizations Join Forces to Induce Projected National Brain Institute to Daejeon
Six major organizations including KAIST have joined forces to help Daejeon City to win the government approval to build the envisioned Korean Brain Institute in Daedeok Research Complex.
The six organizations signed a memorandum of understanding on cooperating in establishing the government-funded institute built within the Daedeok Research Complex in the city of Daejeon, at KAIST on Jan. 14. The six organizations are KAIST, the Daejeon City Government, Korea Research Institute of Bioscience and Biotechnology, Korea Research Institute of Standard and Science, Asan Medical Center, and SK Corp., a pioneer in effective therapeutic invention for serious brain disorders.
The partnership of the six organizations is expected to bring a broad-based cooperation opportunities and create a massive synergy effect in the brain science researches and the development of new therapeutic treatment for brain disorders by combining their resources and infrastructures.
The six organizations have also built an international research network with such globally-renowned brain research institutions as RIKEN, a large natural sciences research institute in Japan, Max Plank Institute in Germany, Federal Institute of Technology, Lausanne, in Switzerland and Brain Research Institute of University of Queensland in Australia. The research network is under the support and guidance of Dennis Choi, a prominent neuroscientist who once served as the President of the Society for Neuroscience and is currently a professor in the Departments of Neurology and biology at Emory University.
The tentatively titled Korea Brain Institute is envisioned to help fight brain disorders and create Korea"s new growth engine, as well as lengthening life span, by conducting convergence researches in nero science, brain science and pharmacology. If the consortium of the six organizations wins the government approval to build the proposed institute within the Daedeok complex, the central government and the Daejeon city government are expected to pour a total of 329.7 billion won into the project by 2020.
2009.01.14 View 15655 -
Workshop on High Risk, High Return Projects Slated for Jan. 14
KAIST will hold the first workshop on "high risk, high return" projects at its Creative Learning Center on Jan. 14.
Under the leadership of President Nam-Pyo Suh, KAIST has instituted high risk, high return research-support programs to encourage creativity and innovation in research activities. Professors and graduate students can apply for HRHR funding any time they have creative ideas that they believe deserve support by the university"s HRHR program.
Once they prove the validity of their ideas, they can then go for the special HRHR funding. The HRHR support does not prevent researcers from applying for any outside sponsorship. Although the program has been in existence for only a short time, the results are encouraing, university authorities said.
Research projects currently underway on such innovative ideas as "transforming ice to icy fuel and ice-like magnets," "mini-lunar lander mission," "mobile floating harbor for increased container handling capacity" and "marine oil spill protection robot design."
During the workshop, a total of 44 research subjects which were picked up in 2008 will be presented. Presentations will be made focused on the three categories; idea, research procedures and current status. Among the 44 research ideas, 40 came from professors and four from students. Posters showing the research content of the 44 subjects will be on display also.
2009.01.08 View 10980 -
Five KAIST Students Offered Internship from Qualcomm
Qualcomm Inc., a wireless telecommunications research and development company based in San Diego, California, has offered internship for five KAIST students of the Department of Electrical Engineering and Computer Science, university authorities said on Monday (Jan. 5).
The five students who are graduate and doctoral students studying communication and RFID (radio frequency identification) design will be working for six months at Qualcomm"s RFIC (radio frequency integrated circuits) Department in Santa Clara, Calif., as co-researchers. These interns will receive about $7,000 a month each with other benefits.
It is the first time that Qualcomm has offered internship for students outside the U.S., according to external relations officials at KAIST. Students who have shown outstanding research output during the internship period will be offered employment at Qualcomm.
"Qualcomm"s internship for KAIST students is designed to help young Korean talents to become professionals who will lead global advancement in the IT sector and strengthen its research network with Korea," Seung-Soo Kim, senior director of Qualcomm Korea, was quoted as saying.
Qualcomm plans to continue providing internship program for KAIST students, as well as pursuing joint research initiatives, the officials said.
2009.01.08 View 14065
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Prof. Seong Publishes English Book on Reliability in Digital Control Systems
Prof. Poong-Hyun Seong of Department of Nuclear and Quantum Engineering has recently published an English-language book on reliability and risk issues in large scale safety-critical digital control systems used in complex facilities such as nuclear power plants.
The book entitled “Reliability and Risk Issues in Large Scale Safety-critical Digital Control Systems” is a result of Prof. Seong’s collaboration with some KAIST graduates who used to be under his guidance. The 303-page publication has been published by Springer, one of the world’s leading publishers of academic journals, as part of the Springer Series in Reliability Engineering.
The book consists of four parts; part I deals with issues related to hardware, part II software, part III human factors and finally the last part integrated systems. It can be purchased through some on-line book stores such as Amazon.com.
Prof. Seong served as an editor-in-chief for Nuclear Engineering and Technology (NET), an international journal of Korean Nuclear Society (KNS), from 2003 to 2008. He also worked as a chair of the Human Factors Division (HFD) of American Nuclear Society (ANS) from 2006 to 2007. Prof. Seong is now a commissioner of Korea Nuclear Safety Commission which is the nation’s highest committee on Nuclear Safety.
2008.12.26 View 14880
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KAIST Scientists Creates Transparent Memory Chip
--See-Through Semis Could Revolutionize Displays
A group of KAIST scientists led by Prof. Jae-Woo Park and Koeng-Su Lim has created a working computer chip that is almost completely clear -- the first of its kind.
The new chip, called "transparent resistive random access memory (TRRAM), is similar in type to an existing technology known as complementary metal-oxide semiconductor (CMOS) memory -- common commercial chips that provide the data storage for USB flash drives and other devices. Like CMOS devices, the new chip provides "non-volatile" memory, meaning that it stores digital information without losing data when it is powered off. Unlike CMOS devices, however, the new TRRAM chip is almost completely clear.
The paper on the new technology, entitled "Transparent resistive random access memory and its characteristics for non-volatile resistive switching," was published in the December issue of the Applied Physics Letters (APL), and the American Institute of Physics, the publisher of APL, issued a press release about this breakthrough.
"It is a new milestone of transparent electronic systems," says researcher Jung-Won Seo, who is the first author of the paper. "By integrating TRRAM devices with other transparent electronic components, we can create a totally see-through embedded electronic system."
Technically, TRRAM devices rely upon an existing technology known as resistive random access memory (RRAM), which is already in commercial development for future electronic data storage devices. RRAM is built using metal oxide materials between equally transparent electrodes and substrates.
According to the research team, TRRAM devices are easy to fabricate and may be commercially available in just 3-4 years.
"We are sure that TRRAM will become one of alternative devices to current CMOS-based flash memory in the near future after its reliability is proven and once any manufacturing issues are solved," says Prof. Jae-Woo Park, who is the co-author on the paper. He adds that the new devices have the potential to be manufactured cheaply because any transparent materials can be utilized as substrate and electrode. They also may not require incorporating rare elements such as Indium.
2008.12.17 View 15789 -
Prof. Cho Wins Best Paper Award
KAIST Prof. Nam-Zin Cho of the Department of Nuclear and Quantum Engineering, won the Best Thesis Award in the nuclear reactor physics category at the 2008 Winter Meeting of the American Nuclear Society held on Nov. 9-13 in Reno, Nevada.
His paper, entitled "Thermal Feedback Transient Analysis of a Pebble Fuel Based on the Two-Temperature Homogenized Model," was jointly authored by Hwi Yu and Jong-Un Kim under the guidance of Prof. Cho.
Prof. Cho was elected a fellow of the American Nuclear Society in 2001 and has served as the deputy editor of the Nuclear Science and Engineering, the research journal of the American Nuclear Society, since 1999.
2008.12.09 View 13232 -
Prof. Kim's Team Wins Silver Prize at International Design Contest
A KAIST team led by Prof. Myung-Suk Kim of the Department of Industrial Design won a silver prize (given by the Mayor of Osaka) at the 17th International Design Competition held at the Osaka International Convention Center on Nov. 27.
The team, made up of KAIST students Da-Woon Chung (representative), Ji-Hoon Kim and Bo-Yeon Kim, presented a sonic energy absorbing (SONEA) system to transform noise energy into electrical energy. At the 2008 competition held under the main theme of "Earth-Life: Clean Aqua, Clean Air, Clean Energy," a Chinese team won the gold prize, Japanese and Korean groups shared silver prizes, and bronze prizes were given to U.S. and German contestants.
It was noteworthy that the KAIST team was the only undergraduate contestants who won the prize. Ji-hoon Kim had already won a bronze prize last year at the same competition.
The International Design Competition Osaka has been held annually or biannually, organized by the Japan Design Foundation, since 1983 and is considered as one of the most prestigious design competitions.
2008.12.09 View 14374 -
Two KAIST Professors Elected Fellows of APS
Profs. Sung-Chul Shin and Chang-Hee Nam of the Department of Physics, KAIST, have recently been elected the 2009 fellows of the American Physical Society (APS), university officials said on Tuesday (Dec. 2).
The APS fellowship is a prestigious recognition of the two professors" outstanding academic achievements in the field of physics, the officials said. The selection criteria are known to be extremely stringent and only a small fraction of APS members become fellows.
Prof. Shin was cited for his pioneering contributions to the understanding of magnetization reversal dynamics, in particular critical scaling behavior of Barkhausen avalanches of 2D ferromagnets, and discovery of novel magnetic thin films and multilayers for high-density data storage.
Prof. Nam was recognized for his contributions to the theory and experiments of physical processes of high harmonic generation for the development of attosecond coherent x-ray sources and related femtosecond laser technology.
The American Physical Society, founded in 1899, is the world"s second largest organization of physicists, behind the Deutsche Physikalische Gesellschaft. It has 46,000 members across the world.
2008.12.04 View 13035 -
Prof. Kwon Unveils Home-Made Lunar Module
A KAIST research team led by Prof. Se-Jin Kwon at the Department of Aerospace Engineering has unveiled a small lunar module developed in cooperation with engineers at a local company, Space Solutions, university authorities said on Thursday (Nov. 27).
The home-made lunar module, the vehicle that conducts survey on the surface of the moon, is 40 centimeters tall and weighs 25 kg. Equipped with a liquid-fuel rocket engine with a maximum thrust of 350 newtons (N), it is capable of carrying objects weighing around 20 kg to the lunar space from the space ship. Professor Kwon"s team held a demonstration of the lander for journalists at a KAIST lab on Friday (Nov. 28).
Lunar landers are critical in developing lunar spacecraft, and countries with advanced aerospace technologies have been careful to protect their core technologies.
According to Prof. Kwon, every part of the rocket engine, including the catalyst, was home made. The rocket"s propulsion system features a state-of-the-art propellant valve developed by Space Solutions, which enables thrust control.
Lunar modules between the 100 and 200 kilogram range, developed by NASA (U.S. National Aeronautics and Space Administration), costs around $100 million, said Kwon. "It is expensive to guarantee the safety of developers of an American module because the fuel contains carcinogens. But the rocket engine created by KAIST team could cut development costs to about half that because it is powered by environmentally friendly fuel," he said.
The lander, product of a six-year-long effort, represents remarkable advancement in the technology for developing spacecraft for lunar missions.
2008.12.01 View 11234 -
2008 IEEE International Conference on Humanoid Robots Opens
The 2008 IEEE-RAS International Conference on Humanoid Robots, an international gathering to identify new research trends and technology in humanoid robotics, will open a three-day session on Monday (Dec. 1) at the Hotel Rivera and KAIST in Daejeon.
The annual conference is organized by KAIST and the Robotics and Automation Society of the Institute for Electric and Electronic Engineers, a U.S.-based international non-profit, professional organization for the advancement of technology related to electricity.
The conference is expected to draw a total of 200 robotics researchers from 19 different countries. Prof. Jun-Ho Oh, at the Department of Mechanical Engineering who led the creation of Korea"s first humanoid robot Hubo, is serving as general chair of the conference. Prof. Oh was named the host of the 2008 conference at the 2007 conference held at the Carnegie Melon University of the United States. The eight-year old conference was inaugurated in Boston in 2000.
On the opening day of Dec. 1, seven lectures will be given on diverse areas of robotics including cognitive humanoid vision, and robot vision sensor and sensing. On the subsequent two days, a total of 110 papers will be presented.
During the conference period, a variety of robots produced by six local and foreign robot makers will be on demonstration, providing opportunities for researchers and industrial robot makers to share technological ideas.
Highlights of the conference will be special lectures by world-renowned robot researchers Prof. Yoshiyuki Sankai of University of Tsukuba, who has created an exoskeletal "robot suit," and Prof. Art Kuo of Univerity of Michigan who is regarded as a leading authority in dynamic walking.
Following the conference, all participants are scheduled to tour Prof. Oh"s Hubo Lab and the Human-Robot Interaction Research Center, both located at KAIST.
2008.12.01 View 12625
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KAIST Collaborating with U.S. Universities to Advance Humanoid Robotics
Hubo, a life-size walking bipedal humanoid robot, is perhaps the best-known character in Korea that KAIST has ever produced. It was shown to the government heads of the Asia-Pacific region during the APEC held in Busan, Korea, in 2005 and appeared at the hit concerts of the pop singer Jang-Hoon Kim. The humanoid robot is soon likely to catch the fancy of Americans as a U.S. government-funded project seeks to create a Hubo that can work and interact with people in collaboration with Korean scientists.
"We are going to give the brains to Hubo. (Japanese) Asimo can do only pre-programmed actions. We want to create a Hubo that can help people, interact with people," said Prof. Paul Oh of the Department of Mechanical Engineering & Mechanics at Drexel University in Philadelphia and leader of the five-year international project which was launched in November 2007.
The U.S.$2.5 million project is funded through the Partnership for International Research and Education (PIRE) Program of the National Science Foundation (NSF) of the United States. It brings together world-renowned experts in humanoid design and information technologies.
"Dr. Jun-Ho Oh"s lab at KAIST (that has created Hubo) is the world"s leader in humanoid design and the U.S. has advanced technologies in the areas such as artificial intelligence, mechanical learning and robot vision. Combining the strengths of the two countries can create a synergy effect and develop a more advanced humanoid robot," said Paul Oh. He is currently serving as Program Director of Robotics of the NSF which is overseeing robotics research (non-military) in the U.S. consisting over 150 robotics faculty.
Paul Oh"s research team consists of experts from five U.S. universities -- Drexel, Bryn Mawr College, Colby College, the University of Pennsylvania and Virginia Tech -- and KAIST.
Leading a delegation of six professors and eight students, Dr. Paul Oh made a two-day visit to KAIST on Nov. 18-19 to review the progress of the project and have a technical meeting with participants.
"The U.S. universities participating in this program are scattered across the nation. So we decided to have a technical meeting here in Korea," he said.
Asked the reason why he chose KAIST as a partner for the program, Dr. Oh said that KAIST is willing to open Hugo to international researchers, whereas in Japan only Honda engineers are allowed to touch Asimo, which is a humanoid robot created by Honda Motor Company.
The project is to establish no barrier for roboticists anywhere in the world to pursue the humanoid research; a suite of humanoid platforms will be available for researchers to develop and advance capabilities like locomotion and human-robot interaction.
The team has been initially involved in development of three tools, all of which are based on the Hubo platform, in order to kick-start humanoid research in the U.S. They are the Mini-Hubo (a small, light-weight and affordable humanoid purchasable at the price lower than $8,000), On-Line Hubo (a program to operate Hubo online) and Virtual Hubo (a simulation program to do researches in cyberspace). As the first outcome of the project, the Mini-Hubo is expected to be released in the U.S. around next April.
Another important purpose of the PIRE program is to seek transformative models to train scientists and engineers to effectively work in global multi-disciplined design teams. To this end, an aggregate number of 20 students from U.S. universities are to stay at the KAIST during the next five years, with two students taking turns on a six-month term.
"I was really amazed how much work is done with small funding here. This is really an excellent example to learn," said Roy Gross, an undergraduate from Drexel who has been staying at Prof. Oh"s Lab for the past three months.
2008.11.21 View 16234