BIO
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10 Technolgies to Change the World in 2012: The Future Technology Global Agenda Council
The Future Technology Global Agenda Council which is under the World Economy Forum and which KAIST’s biochemical engineering department’s Prof. Sang Yeob Lee is the head of, chose the 10 new technologies that will change the world in year 2012.
The ten technologies include: IT, synthetic biology and metabolic engineering, Green Revolution 2.0, material construction nanotechnology, systematic biology and the simulation technology of biological systems, the technology to use CO2 as a natural resource, wireless power transmission technology, high density energy power system, personalized medical/nutritional/disease preventing system, and new education technology.
The technologies were chosen on the basis of the opinions various science, industry, and government specialists and is deemed to have high potential to change the world in the near future.
The Future Technology Global Agenda Council will choose ten new technologies yearly starting this year in order to solve the problems the world now faces.
The informatics systems that was ranked 1st place, sifts only the data necessary for decision making out of the overflowing amount of data. Much interest has been spurred at the Davos forum.
The synthetic biology and metabolic engineering chosen is expected to play an important role in creating new medicines and producing chemical substances and materials from reusable resources.
Biomass has also been chosen as one of the top ten most important technologies as it was seen to be necessary to lead the second Green Revolution in order to stably provide food for the increasing population and to create bio refineries.
Nanomaterials structured at the molecular level are expected to help us solve problems regarding energy, food, and resources.
Systematic biology and computer modeling is gaining importance in availing humans to construct efficient remedies, materials, and processes while causing minimum effects on the environment, resource reserves, and other people.
The technology to convert CO2, which is considered a problem all over the world, into a useful resource is also gaining the spotlight
Together with such technologies, wireless power transmission technology, high density energy power system, personalized medical/nutritional/disease preventing system, and new education technology are also considered the top ten technologies to change the world.
Prof. Lee said, “Many new discoveries are being made due to the accelerating rate of technological advancements. Many of the technologies that the council has found are sustainable and important for the construction of our future.”
2012.04.04 View 11947 -
Distinguished Professor Sang-Yeop Lee gave keynote speech in '2011 China Bio-Refinery Summit'
Distinguished Professor Sang-Yeop Lee gave keynote speech in ‘2011 China Bio-Refinery Summit’ held in Chang’an, Beijing
Professor Lee gave a lecture on the vitalization strategy of ‘Bio-Refinery’, which is ‘A bio-based chemical industry to replace fossil fuel-based petro chemistry.
Professor Lee, insisted that for the successful construction of ‘Bio-Refinery’, there should be innovation in all value chain of biomass; biomass producer, bio-refinery business, consumer, government, etc. ▲Securement and distribution of Biomass ▲Development of strain and process for fermentation separation to effectively change biomass into chemical substance and fuel ▲Optimization of transportation and marketing.
During this summit, high-ranking government officials in politics and economics, executives of multicultural and Chinese business participated. From Korea, Do-Young Seung of Manager of technology research of GS and Hang-Deok Roh of laboratory chief of SK Chemical participated as panelist.
World Economy Forum, the gathering of leaders and experts in politics, economics, and policy created a ‘Global Agenda Council’ to find solutions on the issue of ‘sustainable growth of environment of the Earth and humanity’. Professor Lee is the chairperson of ‘Emerging Technologies Global Agenda Council (GAC)’ of Word Economy Forum.
Professor Lee, founder of ‘Systems Metabolic Engineering’, has made remarkable achievements world-wide, including a technology that manipulates metabolic circuit of microorganisms to purify various crude-originated chemical substances into environmentally friendly substances.
Currently, he is working on Systems biology research business in Ministry of Education, Science and Technology, Global Frontier Biomass business, Global Frontier Intelligent Bio-system construction and composition, to make progress in metabolic engineering which is essential for the bio-chemical industry.
2012.03.06 View 12493
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Bio Pharmaceutical Business Center: Now Open
The Signboard Hanging Ceremony for the Bio Pharmaceutical Business Center for the Integrated Research for the field of Bio Pharmaceutics. 150 representatives from various bio pharmaceutics related businesses and institutes were present for this ceremony.
The Ministry of Education, Science and Technology placed the Molecular Process research team, Personalized Drug Delivery Medium research team, and the newly formed Cancer Cell Detection using Blood research team at the Bio Pharmaceutical Business Center at KAIST.
2012.01.31 View 9280
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'Scientist-Engineer of the Month' for December: Professor Choi Joon Ho
Professor Choi Joon Ho (department of Biological Sciences) was made ‘Scientist-Engineer of December’ for his discovery of new gene (twenty-four) that helps biorhythm and proving that this gene helps control biorhythm.
Professor Choi published 100 dissertations over the past 25 years and made significant advancements in the field of molecular virus and neurobiology.
In 1995 Professor Choi uncovered the fact that the NS3 protein in C type hepatitis function as RNA helicase thereby opening the path to developing a cure for C type hepatitis; this is an international patent with Chiron corporation. The result was published in Biochemical and Biophysical Research Communications Journal and was the most domestically referred to dissertation in biological sciences in 1999.
In addition Professor Choi published in Nature magazine in 1999, a dissertation that uncovered the fact that the DNA of papillomar virus has another protein (hSNF5) that direct it apart from ordinary proteins.
In 2000~2005 Professor Choi published many dissertations in journals like Immunity, Cancer Research, Molecular and Cellular Biology, Oncogene, Journal of Virology, and etc.
Professor Choi screened over 10,000 species of pomace fly mutations and discovered the twenty-four gene that affects the biorhythm of pomace flies. He analyzed this gene further and found a new function that was different from known biorhythm mechanisms.
This research allowed a better understanding of biological clock of pomace flies and therefore was another step towards better understanding the control mechanism of human biological clock.
2012.01.31 View 9887
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Professor Choi Chul Hui appointed as editor-in-chief of Nanobiosensors in a disease diagnosis magazine
Professor Choi Chul Hui of the Department of Biological and Brain Engineering has been appointed the editor-in-chief of Nanobiosensors, an international medical magazine that concentrates on disease diagnosis.
As the editor-in-chief, Professor Choi will be involved in dissertation evaluations and overall direction of the magazine.
Professor Choi is one of the leading authorities in the field of clinical medicine and has published 60 SCI level dissertations in the fields of cell biology, computational biology, and bio-optics.
He is also the executive director of the KAIST BioImaging Research Center, and his research lab focuses on cell signals and bio imaging. Professor Choi is researching the generation process of degenerative diseases like arteriosclerosis by taking a multidisciplinary approach.
Professor Choi has recently developed a new bio imaging technique that allows for the measurement of perfusion and a new technology for the drug delivery to nerves using ultra short wavelength laser beams.
2011.10.10 View 10939 -
Cancer detection from an implantable, flexible LED
Professor Keon Jae Lee
A KAIST research team has developed a new type of biocompatible and bendable GaN LED biosensor.
Daejeon, the Republic of Korea, August 8, 2011—Can a flexible LED conformably placed on the human heart, situated on the corrugated surface of the human brain, or rolled upon the blood vessels, diagnose or even treat various diseases? These things might be a reality in the near future.
The team of Professor Keon Jae Lee (Department of Materials Science and Engineering, KAIST) has developed a new concept: a biocompatible, flexible Gallium Nitride (GaN) LED that can detect prostate cancer.
GaN LED, a highly efficient light emitting device, has been commercialized in LED TVs and in the lighting industry. Until now, it has been difficult to use this semiconductor material to fabricate flexible electronic systems due to its brittleness. The research team, however, has succeeded in developing a highly efficient, flexible GaN LED and in detecting cancer using a flexible LED biosensor.
Prof. Lee was involved in the first co-invention of "High Performance Flexible Single Crystal GaN" during his PhD course at the University of Illinois at Urbana-Champaign (UIUC). This flexible GaN LED biosensor utilized a similar protocol to transfer thin GaN LED films onto flexible substrates, followed by a biocompatible packaging process; the system’s overall potential for use in implantable biomedical applications was demonstrated.
Professor John Roger (Department of Materials Science and Engineering, UIUC) said,
“Bio-integrated LEDs represent an exciting, new technology with strong potential to address important challenges in human health. This present work represents a very nice contribution to this emerging field.”
This paper was published in the online issue of Nano Energy Elsevier Journal (Editor, Prof. Zhong Lin Wang) dated September 16, 2011.
Flexible GaN LED produces blue light.
2011.09.20 View 12086 -
Future of Petrochemical Industry: The Age of Bio-Refineries
The concept of bio-refinery is based on using biomass from seaweeds and non-edible plant sources to produce various materials.
Bio-refineries has been looked into with increasing interest in modern times due to the advent of global warming (and the subsequent changes in the atmosphere) and the exhaustion of natural resources.
However past 20 years of research in metabolic engineering had a crucial limitation; the need to improve the efficiency of the microorganisms that actually go about converting biomass into biochemical materials.
In order to compensate for the inefficiency, Professor Lee Sang Yeop combined systems biology, composite biology, evolutionary engineering to form ‘systems metabolic engineering’.
This allows combining various data to explain the organism’s state in a multi-dimensional scope and respond accordingly by controlling the metabolism.
The result of the experiment is set as the cover dissertation of ‘Trends in Biotechnology’ magazine’s August edition.
2011.07.28 View 12054
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Biomimetic Carbon Nanotube Fiber Synthesis Technology Developed
The byssus of the mussel allows it to live in harsh conditions where it is constantly battered by crashing waves by allowing the mussel to latch onto the seaside rocks. This particular characteristic of the mussel is due to the unique structure and high adhesiveness of the mussel’s byssus.
KAIST’s Professor Hong Soon Hyung (Department of Material Science and Engineering) and Professor Lee Hae Shin (Department of Chemistry) and the late Professor Park Tae Kwan (Department of Bio Engineering) were able to reproduce the mussel’s byssus using carbon nanotubes.
The carbon nanotube, since its discovery in 1991, was regarded as the next generation material due to its electrical, thermal, and mechanical properties. However due to its short length of several nanometers, its industrial use was limited.
The KAIST research team referred to the structure of the byssus of the mussel to solve this problem.
The byssus is composed of collagen fibers and Mefp-1 protein which are in a cross-linking structure. The Mefp-1 protein has catecholamine that allows it to bind strongly with the collagen fiber.
In the artificial structure, the carbon nanotube took on the role of the collagen fibers and the macromolecular adhesive took on the role of the catecholamine. The result was a fiber that was ultra-light and ultra-strong.
The results of the experiment were published in the Advanced Materials magazine and is patent registered both domestically and internationally.
2011.06.20 View 13339
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Artificial Spore Production Technology Developed
The core technology needed in the development of ‘biosensors’ so crucial in diagnosing illnesses or pathogens was developed by Korean research team.
KAIST’s Professor Choi In Seung of the department of Chemistry developed the technology that allows for the production of Artificial Spore by selectively coating a live cell.
In the field of engineering the problem in developing the next generation bio sensor, the cell based sensor, was that it was difficult to keep a cell alive without division for a long time. Once a cell is taken out of the body, it will either divide or die easily.
Professor Choi’s research team mimicked the spore, which has the capability to survive harsh conditions without division, and chemically coated a live cell and artificially created a cell similar to that of a spore.
The physical and biological stabilities of the cell increased by coating an artificial shell over the yeast cell. The shell is composed with a protein similar to that of the protein that gives mussels its stickiness. In addition by controlling the thickness of the shell, the division rate of the yeast can be controlled.
Professor Choi commented that this technology will serve as the basis for the single cell based biosensor.
The research was conducted together with Professor Lee Hae Shin of KAIST department of Chemistry and Professor Jeong Taek Dong of Seoul National University’s department of Chemistry and was published as the cover paper of ‘Journal of the American Chemical Society’.
2011.04.01 View 13539
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New Bio-Clock gene and its function found
The Ministry of Education, Science and Technology announced that a Korean research team has found a new gene responsible for maintaining the bio-clock (twenty-four) and its mechanism.
Twnety-four was led by Professor Choi Joon Ho and Dr. Lee Jong Bin of KAIST (department of Biology) and was a joint operation with Professor Ravi Allada and Dr.Lim Jeong Hoon of Northwestern University (department of neurobiology) and the result was published in ‘Nature’ magazine.
The research team experimented with transformed small fruit flies for 4 years and found that there was an undiscovered gene that deals with the bio rhythm in the brain which they named ‘twenty-four’.
The understanding with genes prior to twenty-four was that these genes regulate biorhythm in the transcription phase (DNA to mRNA). Twenty-four operates in the step after transcription when the ribosome creates proteins. Especially twenty-four has a great effect on the ‘period protein’ which acts as a sub-atomic clock that regulates the rhythm and life of each cell.
The experiment was innovational in that it was able to scientifically prove the function of the protein produced by the gene.
The result is expected to help solve the problems associated with sleep disorders, jetlags, eating rhythms, bio rhythms, etc.
The name twenty-four was the fact that a day, a cycle, is 24 hours long and the gene’s serial numbers CG4857 adds up to twenty four.
2011.02.23 View 12691
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Success in differentiating Functional Vascular Progenitor Cells (VPC)
KAIST’s Professor Han Yong Man successfully differentiated vascular progenitor cells from human embryonic stem cells and reversed differentiated stem cells.
The research went beyond the current method of synthesis of embryonic body or mice cell ball culture and used the careful alteration of signal transmission system of the human embryonic stem cells to differentiate the formation of vascular progenitor cells.
The team controlled the MEK/ERK and BMP signal transmission system that serves an important role in the self replication of human embryonic stem cells and successfully differentiated 20% of the cells experimented on to vascular progenitor cells.
The vascular progenitor cells produced with such a method successfully differentiated into cells forming the endodermis of the blood vessel, vascular smooth muscle cells and hematopoietic cells in an environment outside of the human body and also successfully differentiated into blood vessels in nude mice.
In addition, the vascular progenitor cell derived from human embryonic cells successfully formed blood vessels or secreted vascular growth factors and increased the blood flow and the necrosis of blood vessels when injected into an animal with limb ischemic illness.
The research was funded by the Ministry of Education, Science and Technology, 21st Century Frontier Research and Development Institution’s Cell Application Research Department and Professor Ko Kyu Young (KAIST), Professor Choi Chul Hee (KAIST), Professor Jeong Hyung Min (Cha Medical School) and Doctor Jo Lee Sook (Researcher in Korea Bio Engineering Institute) participated in it.
The results of the research was published as the cover paper of the September edition of “Blood (IF:10.55)”, the American Blood Journal and has been patented domestically and has finished registration of foreign PCT.
The results of the experiment opened the possibility of providing a patient specific cure using stem cells in the field of blood vessel illness.
2011.01.18 View 14668 -
Explanation for the polymerized nucleic acid enzyme's abnormal activation found
KAIST’s Professor Park Hyun Kyu of the Department of Bio Chemical Engineering revealed on the 23rd of December 2010 that his team had successfully developed the technology that uses the metal ions to control the abnormal activation of nucleic acids’ enzymes and using this, created a logic gate, which is a core technology in the field of future bio electrons.
The polymerized nucleic acid enzyme works to increase the synthesis of DNA and kicks into action only when the target DNA and primers form complimentary pairs (A and T, C and G).
Professor Park broke the common conception and found that it is possible for none complimentary pairs like T-T and C-C to initiate the activation of the enzyme and thus increase the nucleic acid production, given that there are certain metal ions present.
What Professor Park realized is that the enzymes mistake the uncomplimentary T-T and C-C pairs (with stabilized structures due to the bonding with mercury and silver ions) as being complimentary base pairs. Professor Park described this phenomenon as the “illusionary polymerase activity.”
The research team developed a logic gate based on the “illusionary polymerase activity’ phenomenon.” The logic gate paves the way to the development of future bio electron needed for bio computers and high performance memories.
Professor Park commented, “The research is an advancement of the previous research carried on about metal ions and nucleic acid synthesis. Our research is the first attempt at merging the concepts of the two previously separately carried out researches and can be adapted for testing presence of metal ions and development of a new single nucleotide polymorphic gene analysis technology.”
Professor Park added that, “Our research is a great stride in the field of nano scale electron element research as the results made possible the formation of accurate logic gates through relatively cost efficient and simple system designs.”
On a side note, the research was funded by Korea Research Foundation (Chairman: Park Chan Mo) and was selected as the cover paper for the December issue of ‘Angewandte Chemie International Edition’.
2011.01.18 View 11931