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KAIST to support the Genetic Donguibogam Research Project for global market entry of a new natural drug produced by Green Cross Corporation HS
In the wake of the spread of the Middle East Respiratory Syndrome (MERS), sales of immune-enhancing products in Korea such as red and white ginseng have risen dramatically. Ginseng is one of Korea’s major health supplement it exports, but due to the lack of precise scientific knowledge of its mechanism, sales of ginseng account for less than 2% of the global market share.
The Genetic Donguibogam Research Project represents a group of research initiatives to study genes and environmental factors that contribute to diseases and to discover alternative treatments through Eastern medicine. The project is being led by KAIST’s Department of Bio & Brain Engineering Professor Do-Heon Lee.
Professor Lee and Chief Executive Officer Young-Hyo Yoo of Green Cross Corporation HS, a Korean pharmaceutical company, signed a memorandum of understanding (MOU), as well as a non-disclosure agreement (NDA) to develop a naturally derived drug with an enhanced ginsenoside, pharmacological compounds of ginseng, for the global market entry of BST204 on June 10, 2015.
Donguibogam is the traditional Korean source for the principles and practice of Eastern medicine, which was compiled by the royal physician Heo Jun and first published in 1613 during the Joseon Dynasty of Korea.
Cooperating with Green Cross Co., HS, KAIST researchers will use a multi-component, multi-target (MCMT)-based development platform to produce the new natural drug, BST204. This cooperation is expected to assist the entry of the drug into the European market.
Green Cross Co., HS has applied a bio-conversion technique to ginseng to develop BST204, which is a drug with enhanced active constituent of aginsenosides. The drug is the first produced by any Korean pharmaceutical company to complete the first phase of clinical trials in Germany and is about to start the second phase of trials.
Professor Do-Heon Lee, the Director of the project said, “Genetic Donguibogam Research Project seeks to create new innovative healthcare material for the future using integrated fundamental technologies such as virtual human body computer modelling and multi-omics to explain the mechanism in which natural ingredients affect the human body.” He continued, “Especially, by employing the virtual human body computer modelling, we can develop an innovative new technology that will greatly assist Korean pharmaceutical industry and make it the platform technology in entering global markets.”
Young-Hyo Yoo, the CEO of Green Cross Co., HS, said, “For a new naturally derived drug to be acknowledged in the global market, such as Europe and the US, its mechanism, as well as its effectiveness and safety, should be proven. However, it is difficult and costly to explain the mechanism in which the complex composition of a natural substance influences the body. Innovative technology is needed to solve this problem.”
Professor Do-Heon Lee (left in the picture), the Director of Genetic Donguibogam Research Project, stands abreast Young-Hyo Yoo (right in the picture), the CEO of Green Cross Co., HS.
2015.06.10 View 8875 -
KAIST's DRC-HUBO Wins the DARPA Robotics Challenge 2015
DRC-HUBO finished all eight assignments in less than 45 minutes, taking first place among 24 international teams and claiming the USD 2 million prize offered by a US defense research agency.
The Robotics Challenge Finals 2015 hosted by the US Defense Advanced Research Projects Agency (DARPA) took place on June 5-6, 2015 at the Fairplex in Pomona, California.
Team KAIST of the Republic of Korea led by Professor Jun-Ho Oh of the Mechanical Engineering Department at the Korea Advanced Institute of Science and Technology (KAIST), Professor In-So Kweon of the Electrical Engineering Department, and researchers from Rainbow Co., the university’s spin-off company that builds the robots, won the DARPA Finals. The team received USD 2 million as a prize.
The DARPA’s Robotics Challenge (DRC) promotes a competition of robot systems and software teams which seek to develop robots capable of assisting humans in responding to natural and man-made disasters such as the Fukushima Daiichi nuclear incident in 2011. The DRC consists of three competitions: a software-based Virtual Robotics Challenge which took place in June 2013; the Robotics Challenge Trials in Homestead, Florida, in December 2013; and the Finals in June 2015.
A total of 24 teams from universities and private and public research institutes from Korea, the US, Hong Kong, Germany, Japan, and Italy participated in the Finals. The participating teams had to finish eight assignments in 60 minutes, during which their robots were untethered and operated wirelessly without communication from their engineers.
Each team was assigned a series of tasks: they included driving a vehicle, getting out of a vehicle, opening a door, turning a valve, drilling a hole in a wall, a surprise task such as pushing a button or turning on a switch, walking over rubble or debris, and climbing stairs. Robots scored a point each time they completed their missions. To win, a team had to complete all the tasks successfully in the shortest amount of time possible.
Team KAIST completed the entire course in 44 minutes and 28 seconds, followed by the Institute of Human and Machine Cognition (IHMC) Robotics in Pensacola, Florida in 50:26, and Team TARTAN Rescue of the National Robotics Engineering Center at Carnegie Mellon University in 55:15.
For details, see an article below from the New York Times:
New York Times, June 6, 2015
“Korean Robot Makers Walk Off With $2 Million Prize”
http://www.nytimes.com/2015/06/07/science/korean-robot-makers-walk-off-with-2-million-prize.html?_r=1
DRC-HUBO sticks a plug into an outlet for the surprise task at the 2015 DARPA Robotics Challenge on June 5-6, 2015, in Pomona, California.
DRC-HUBO turns a valve in a clockwise direction.
DRC-HUBO drills to cut a circle into the wall.
Members of Team KAIST pose together after the award ceremony on June 6, 2015.
2015.06.07 View 23834 -
KAIST to Kick-Start the Exchange of Young Researchers with Northern European Universities
KAIST promotes research exchange and cooperation with three universities in Northern Europe.
KAIST has signed a letter of intent (LOI) for the mutual exchange of young researchers and cooperation to collaborate with KTH Royal Institute of Technology and Lund University, both based in Sweden on June 2, 2015, and with Aalto University in Finland on June 4, 2015.
This LOI was the result of the cooperative projects of Korea-Sweden and Korea-Finland Joint Committees on Science and Technology supervised by the Ministry of Science, ICT and Future Planning of Korea.
As agreed in the LOI, KAIST will conduct joint research projects with the three universities by providing students and researchers with opportunities to visit each other through internship programs and workshops and by sharing information on education and research.
Sung-Hyon Mayeng, the Associate Vice President of the International Relations Office at KAIST, said, “It’s an encouraging sign that universities and governments recognize the importance of increasing exchanges among academic and research communities. Expecting more vibrant relationships to be formed between KAIST and the three northern European universities in coming years, I hope that today’s agreement becomes a good basis to spur technological innovations that will not only benefit the regions but also the world.”
Established in 1827, the KTH Royal Institute of Technology is the largest and oldest technical university in Sweden, accounting for one-third of the nation’s technical research and engineering education capacity at university level. The university offers education and research programs from natural sciences to all branches of engineering including architecture, industrial management, and urban planning. According to the QS World University Rankings in 2014, KTH Royal Institute of Technology ranked 27th in engineering and 1st in Northern Europe.
Lund University, Sweden, is one of the oldest and most prestigious universities in northern Europe, consistently ranking among the world’s top 100 universities. In particular, its biological sciences and engineering have shown great strength, placing within the top 60 universities by the Times Higher Education (THE) World University Rankings. The university also receives the largest amount of research funding from the Swedish government.
Aalto University in Finland was created as a merger of three leading Finnish universities: the Helsinki University of Technology (established 1849), the Helsinki School of Economics (established 1904), and the University of Art and Design Helsinki (established 1871). The university nurtures the close collaborations across science, business, and arts to foster multi-disciplinary education and research.
2015.06.04 View 8446 -
Professor Jinwoo Shin Receives the Bloomberg Scientific Research Award
Professor Jinwoo Shin (https://sites.google.com/site/mijirim/) of the Electrical Engineering Department at KAIST has been selected as one of the three winners to receive the first Bloomberg Scientific Research Award this month. The newly created award is presented to researchers in computer science who conduct high-quality research in such areas as machine learning, natural language processing, machine translation, statistics, and theory.
Professor Shin submitted his research proposal entitled “Scalable Probabilistic Deep Leaning,” and the award will support funding his research for one year. For details, please click on the link below for an article released by Bloomberg News, announcing the winners of the award:
Bloomberg News, April 28, 2015
“Announcing the Winners of the Bloomberg’s First Scientific Research Program”
https://3blmedia.com/News/Announcing-Winners-Bloombergs-First-Scientific-Research-Program
2015.04.30 View 8133 -
KAIST & the Classic 500 Co Sign for Mobile Healthcare Research
KAIST and The Classic 500 Co., Ltd., an elder care provider based in Seoul, signed a memorandum of understanding to expand medical services by cooperating on the research of medical services and IT on March 24, 2015.
Twenty people from the two institutions, including President Steve Kang, Dong-Hyun Bak, CEO of The Classic 500 and Mun-Sul Jeong, a former KAIST Chairman of the Board, attended the signing ceremony.
Under the agreement, the two institutions will cooperate on mobile healthcare research and the development of a telemedicine system. They will also research and develop a system to better serve society with medical services.
The Classic 500, established by Konkuk University in Korea, provides nursing care services and assisted living facilities for senior citizens.
2015.03.26 View 8706 -
KAIST and Hancom Sign for Development of Mobile Healthcare
KAIST signed a memorandum of understanding with Hancom, Inc., an office suite developer in Korea, to foster mobile healthcare software programs. President Steve Kang and Chairman Sang-Chul Kim of Hancom held a signing ceremony on March 13, 2015 at the KAIST campus.
Based on the agreement, KAIST and Hancom will exchange research personnel to build Dr. M, a smart healthcare platform developed by the university, collaborate in research and development, and cooperate in the transfer of research developments from the university to the software industry including Hancom.
KAIST and Hancom also signed a memorandum of understanding on the development of software in April 2014. The Hancom-KAIST Research Center opened on campus last October.
2015.03.20 View 9317 -
The Real Time Observation of the Birth of a Molecule
From right to left: Dr. Kyung-Hwan Kim, Professor Hyotcherl Lhee, and Jong-Gu Kim, a Ph.D. candidate
Professor Hyotcherl Lhee of the Department of Chemistry at KAIST and Japanese research teams jointly published their research results showing that they have succeeded in the direct observation of how atoms form a molecule in the online issue of Nature on February 19, 2015.
The researchers used water in which gold atoms ([Au(CN) 2- ]) are dissolved and fired X-ray pulses over the specimen in femtosecond timescales to study chemical reactions taking place among the gold atoms. They were able to examine in real time the instant process of how gold atoms bond together to become a molecule, to a trimer or tetramer state.
This direct viewing of the formation of a gold trimer complex ([Au(CN) 2- ] 3 ) will provide an opportunity to understand complex chemical and biological systems.
For details, please see the following press release that was distributed by the High Energy Accelerator Research Organization, KEK, in Japan:
Direct Observation of Bond Formations
February 18, 2015
A collaboration between researchers from KEK, the Institute for Basic Science (IBS), the Korea Advanced Institute of Science and Technology (KAIST), RIKEN, and the Japan Synchrotron Radiation Research Institute (JASRI) used the SACLA X-ray free electron laser (XFEL) facility for a real time visualization of the birth of a molecular that occurs via photoinduced formation of a chemical bonds. This achievement was published in the online version of the scientific journal “Nature” (published on 19 February 2015).
Direct “observation” of the bond making, through a chemical reaction, has been longstanding dream for chemists. However, the distance between atoms is very small, at about 100 picometer, and the bonding is completed very quickly, taking less than one picosecond (ps). Hence, previously, one could only imagine the bond formation between atoms while looking at the chemical reaction progressing in the test-tube.
In this study, the research group focused on the process of photoinduced bond formation between gold (Au) ions dissolved in water. In the ground state (S 0 state in Fig. 1) Au ions that are weakly bound to each other by an electron affinity and aligned in a bent geometry. Upon a photoexcitation, the S 0 state rapidly converts into an excited (S 1 state in Fig. 1) state where Au-Au covalent bonds are formed among Au ions aligned in a linear geometry. Subsequently, the S 1 state transforms to a triplet state (T 1 state in Fig. 1) in 1.6 ps while accompanying further contraction of Au-Au bonds by 0.1 Å. Later, the T 1 state of the trimer converts to a tetramer (tetramer state in Fig. 1) on nanosecond time scale. Finally, the Au ions returned to their original loosely interacting bent structure.
In this research, the direct observation of a very fast chemical reaction, induced by the photo-excitation, was succeeded (Fig. 2, 3). Therefore, this method is expected to be a fundamental technology for understanding the light energy conversion reaction. The research group is actively working to apply this method to the development of viable renewable energy resources, such as a photocatalysts for artificial photosynthesis using sunlight.
This research was supported by the X-ray Free Electron Laser Priority Strategy Program of the MEXT, PRESTO of the JST, and the the Innovative Areas "Artificial Photosynthesis (AnApple)" grant from the Japan Society for the Promotion of Science (JSPS).
Publication: Nature , 518 (19 February 2015)
Title: Direct observation of bond formation in solution with femtosecond X-ray scattering
Authors: K. H. Kim 1 , J. G. Kim 1 , S. Nozawa 1 , T. Sato 1 , K. Y. Oang, T. W. Kim, H. Ki, J. Jo, S. Park, C. Song, T. Sato, K. Ogawa, T. Togashi, K. Tono, M. Yabashi, T. Ishikawa, J. Kim, R. Ryoo, J. Kim, H. Ihee, S. Adachi. ※ 1: These authors contributed equally to the work.
DOI: 10.1038/nature14163
Figure 1. Structure of a gold cyano trimer complex (Au(CN) 2 - ) 3 .
Figure 2. Observed changes in the molecular structure of the gold complex
Figure 3. Schematic view of the research of photo-chemical reactions by the molecular movie
2015.02.27 View 12459 -
KAIST Develops Subminiature, Power-Efficient Air Pollution Sensing Probe
Professor Inkyu Park and his research team from the Department of Mechanical Engineering at KAIST have developed a subminiature, power-efficient air-pollution sensing probe that can be applied to mobile devices. Their research findings were published online in the January 30th issue of Scientific Reports.
As air pollution has increased, people have taken greater interest in health care. The developed technology could allow people to measure independently the air pollution level of their surrounding environments.
Previous instruments used to measure air pollution levels were bulky and consumed a lot of power. They also often produced inaccurate results when measuring air pollution in which different toxic gases were mixed. These problems could not be resolved with existing semiconductor manufacturing process.
Using local temperature field control technology, Professor Park’s team succeeded in integrating multiple heterogeneous nanomaterials and fitting them onto a small, low-power electronic chip. This microheating sensor can heat microscale regions through local hydrothermal synthesis. Because it requires a miniscale amount of nanomaterials to manufacture, the sensor is most suitable for mobile devices.
Professor Park said, “Our research will contribute to the development of convergence technology in such field as air pollution sensing probes, biosensors, electronic devices, and displays.”
The team's research was supported by the Ministry of Education and the Ministry of Science, ICT and Future Planning, Republic of Korea.
Figure 1 – The Concept of Multiple Nanomaterial Device and Numerical Simulation Results of Precursor Solutions
Figure 2 - Multiple Nanomaterial Manufactured in a Microscale Region
2015.02.27 View 10703 -
KAIST Announces the Recipients of Distinguished Alumni Awards
The KAIST Alumni Association (KAA) announced four “Proud KAIST Alumni” awards recipients for the year 2014: Sung-Wook Park, the Chief Executive Officer and President of SK Hynix; Seung Ho Shin, the President of Kangwon National University; Kew-Ho Lee, the President of the Korea Research Institute of Chemical Technology; and Mun-Kee Choi, the former Minister of Science, ICT and Future Planning of the Republic of Korea. The award ceremony took place during the 2015 KAA’s New Year's ceremony on January 17, 2015 at the Palace Hotel in Seoul.
Sung-Wook Park (M.S. ’82 and Ph.D. ’88, Department of Materials Science and Engineering), the Chief Executive Officer and President of SK Hynix, has worked as an expert in the field of memory semi-conductors for the past 30 years. He developed innovative technology and improved production efficiency, enabling the Korean semi-conductor industry to become a global leader.
Seung Ho Shin (M.S. ’79 and Ph.D. ’87, Department of Physics), the President of Kangwon National University (KNU), worked in the field of optical information processing, producing excellent research achievements and teaching the next generation of scientists. As the president of KNU, he has set an exemplary leadership in higher education.
Kew-Ho Lee (M.S. ’75, Department of Chemistry), the President of the Korea Research Institute of Chemical Technology, pioneered the field of separation film production which contributed greatly to Korean technological developments. He led several domestic and international societies to facilitate dynamic exchanges between industry and academia and with the international community.
Mun-Kee Choi (M.S. ’76, Department of Industrial and Systems Engineering), the former Minister of Science, ICT and Future Planning, the Republic of Korea, is a great contributor to the information and communications technology in Korea, working as a leader in the field of broadband integrated service digital network. He is also an educator for gifted students in science and technology, and a manager of the Electronics and Telecommunications Research Institute.
The Alumni Association established the “Proud KAIST Alumni Awards” in 1992 to recognize its alumni’s outstanding contributions to Korea and KAIST.
Pictured from left to right, Sung-Wook Park (the Chief Executive Officer and President of SK Hynix), Seung Ho Shin (the President of Kangwon National University), Kew-Ho Lee (the President of the Korea Research Institute of Chemical Technology), and Mun-Kee Choi (the former Minister of Science, ICT and Future Planning)
2015.01.19 View 14522 -
Hierarchically-Porous Polymers with Fast Absorption
KAIST's Professor Myungeun Seo and his research team from the Graduate School of Nanoscience and Technology has developed a method to form micropores of less than 2 nanometers within porous polymers where 10 nanometers long mesopores connect like a net. The advantage of the porous polymers is fast absorption of molecules.
Porous polymers with micropores of less than 2 nanometers, like a zeolite, have a large surface area. They are used as a means to store hydrogen-based molecules or as a catalytic support that can be used as a surface to convert a material into a desired form. However, because the size of the pores in its path was too small for the molecules, it took a long time to spread into the pores and reach the surface.
To reach the surface efficiently, a lung cell or the vein of a leaf has a structure wherein the pores are subdivided into different sizes so that the molecule can spread throughout the organ. A technology that can create not only micropores but also bigger pores was necessary in order to create such structure.
The research team solved the issue by implementing a "self-assembly" of block polymers to easily form a net-like nanostructure from mesopores of 10 nanometers.
The team created hierarchically-porous polymers consisting of two different types of pores by using a hypercrosslinking reaction along with the "self-assembly" method. The reaction creates micropores within the chain after the polymer chain is confined by a chemical bond.
This porous polymer has micropores that are smaller than 2 nanometers on the walls of mesopores while 10 nanometers long mesopores forming 3-dimensional net structures. Because of the "self-assembly" method, the size of mesopores can be adjusted within the range of 6 to 15 nanometers.
This is the first case where a porous polymer has both well-defined mesopores and micropores. The research team verified the effect of hierarchically-porous structures on absorption of molecules by confirming that the porous polymer had faster absorption speeds than a polymer consisting only of micropores.
Professor Seo said, “The study has found a simple way to create different sizes of pores within a polymer.” He expected that the hierarchically-porous polymers can be used as a catalytic support in which fast diffusion of molecules is essential, or for molecule collection.
The research was sponsored by National Research Foundation of Korea and published online in the Journal of the American Chemical Society.
Figure 1 – Net-like Structure of Hierarchically-Porous Polymers with Mesopores and Micropores on the walls of Mesopores.
Figure 2 - Hierarchically-Porous Polymers
Figure 3 – Comparison of Porous-Polymers consisting of Mesopores only (left), and Mesopores and Micropores (right)
2015.01.13 View 8812 -
A Key Signal Transduction Pathway Switch in Cardiomyocyte Identified
A KAIST research team has identified the fundamental principle in deciding the fate of cardiomyocyte or heart muscle cells. They have determined that it depends on the degree of stimulus in β-adrenergic receptor signal transduction pathway in the cardiomyocyte to control cells' survival or death. The findings, the team hopes, can be used to treat various heart diseases including heart failure.
The research was led by KAIST Department of Bio and Brain Engineering Chair Professor Kwang-Hyun Cho and conducted by Dr. Sung-Young Shin (lead author) and Ph.D. candidates Ho-Sung Lee and Joon-Hyuk Kang. The research was conducted jointly with GIST (Gwangju Institute of Science and Technology) Department of Biological Sciences Professor Do-Han Kim’s team. The research was supported by the Ministry of Science, ICT and Future Planning, Republic of Korea, and the National Research Foundation of Korea. The paper was published in Nature Communications on December 17, 2014 with the title, “The switching role of β-adrenergic receptor signalling in cell survival or death decision of cardiomyocytes.”
The β-adrenergic receptor signal transduction pathway can promote cell survival (mediated by β2 receptors), but also can result in cell death by inducing toxin (mediated by β1 receptors) that leads to various heart diseases including heart failure. Past attempts to identify the fundamental principle in the fate determining process of cardiomyocyte based on β-adrenergic receptor signalling concluded without much success.
The β-adrenergic receptor is a type of protein on the cell membrane of cardiomyocyte (heart muscle cell) that when stimulated by neurohormones such as epinephrine or norepinephrine would transduce signals making the cardiomyocyte contract faster and stronger.
The research team used large-scale computer simulation analysis and systems biology to identify ERK* and ICER** signal transduction pathways mediated by a feed-forward circuit as a key molecular switch that decides between cell survival and death.
Weak β-adrenergic receptor stimulations activate ERK signal transduction pathway, increasing Bcl-2*** protein expression to promote cardiomyocyte survival. On the other hand, strong β-adrenergic receptor stimulations activate ICER signal transduction pathway, reducing Bcl-2 protein expression to promote cardiomyocyte death.
Researchers used a systems biology approach to identify the mechanism of B-blocker****, a common drug prescribed for heart failure. When cardiomyocyte is treated with β1 inhibitor, strong stimulation on β-adrenergic receptor increases Bcl-2 expression, improving the chance of cardiomyocyte survival, a cell protection effect.
Professor Kwang-Hyun Cho said, “This research used systems biology, an integrated, convergence research of IT (information technology) and BT (biotechnology), to successfully identify the mechanism in deciding the fate of cardiomyocytes based on the β-adrenergic receptor signal transduction pathway for the first time. I am hopeful that this research will enable the control of cardiomyocyte survival and death to treat various heart diseases including heart failure.”
Professor Cho’s team was the first to pioneer a new field of systems biology, especially concerning the complex signal transduction network involved in diseases. Their research is focused on modelling, analyzing simulations, and experimentally proving signal pathways. Professor Cho has published 140 articles in international journals including Cell, Science, and Nature.
* ERK (Extracellular signal-regulated kinases): Signal transduction molecule involved in cell survival
** ICER (Inducible cAMP early repressor): Signal transduction molecule involved in cell death
*** Bcl-2 (B-cell lymphoma 2): Key signal transduction molecule involved in promotion of cell survival
**** β-blocker: Drug that acts as β-adrenergic receptor inhibitor known to slow the progression of heart failure, hence used most commonly in medicine.
Picture: A schematic diagram for the β-AR signalling network
2015.01.05 View 13619 -
Professor Mikyoung Lim Receives the MediaV Young Researcher Award
Professor Mikyoung Lim of the Department of Mathematical Sciences at KAIST received the MediaV Young Researchers Award at the International Conference on Inverse Problems and Related Topics that took place at the National Taiwan University, Taiwan, on December 15-19, 2014.
The Conference established the MediaV Young Researcher Award in 2010 to recognize distinguished scholars who are age 40 or younger and have made important contributions to the field of inverse problems. This year, two recipients were chosen for the award.
Professor Lim has focused her research on the incremental reading of incomprehensible materials’ imaging and the effect of invisibility cloaking.
The other awardee was Kui Ren, a professor at the University of Texas at Austin.
2014.12.27 View 10996