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Low Cost and Simple Gene Analysis Technology Developed
Professor Park Hyun Kyu of the Department of Biology and Chemical Engineering has developed a ‘real time CPR’ using Methylene Blue (nucleic acid bonding molecule with Electro-Chemical property).
The current gene analysis being used in the field is the real time PCR (Polymerase Chain Reaction) which takes advantage of the luminescent property of the gene and therefore requires expensive machines and chemicals to run.
By contrast, the electro-chemical method is easy to use and low cost and, most importantly, it allows the machine to become small and portable.
Professor Park’s research team used the decrease in the electro-chemical signal when the Methylene Blue reacts with nucleic acid and applied this to PCR which allowed for the real time analysis of the nucleic acid amplification process.
With the result of the experiment as the basis, the team was able to perform a trial with Chlamydia trachomatis, a pathogen that causes sexually transmitted disease.
The result showed that the electro-chemical method showed the same performance level as the real time PCR, which proved that the technology can be applied to diagnosing various diseases and gene research.
2011.04.30 View 10851 -
The Irish Times: Gene link identified in ADHD, April 18, 2011
The Irish Times wrote an article on the recent research breakthrough made by a KAIST research team to identify a gene that triggers the syndrome of Attention Deficit Hyperactivity Disorder (ADHD) among children. Given the heightened attention to the syndrome across the world, the research result has received a great deal of attention not only from the academia but also from the media and public.
For the article, please visit http://www.irishtimes.com/newspaper/ireland/2011/0418/1224294910305.html. The research paper was appeared online April 17, 2011 in Nature Medicine, which will be printed in its May 2011 issue. For the paper, please click the link of http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.2330.html.
2011.04.18 View 10820
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MOU on Joint Research Program with KUSTAR
KAIST has signed a MOU on Joint Research Program with KUSTAR (Khalifa, University of Science, Technology, and Research).
The Signing ceremony was held in UAE Abu Dhabi with KAIST President Seo Nam Pyo and KUSTAR Presdient Tod Laursen in attendance.
The MOU contains agreements on seed money project, exchange professors and students program, seminars and workshops, and cooperative closely through funding joint research facilities among other key agreements.
The two universities are considering joint research on educational nuclear power plant simulator, research use nuclear reactor plans and nuclear reactor for saltwater desalination plants. In addition, the field of cooperation will not be limited to nuclear power, but will be broadened to electric and electronic, mechanical engineering, aeronautical engineering, industrial engineering, construction environment, and other fields by appointing KAIST professors to perform educational cooperation programs at KUSTAR.
The cooperation is part of the agreement made by the two respective countries in the Korea export of nuclear power plants to UAE in 2009. KAIST will be helping KUSTAR to develop into a world leading science and technology based education and research institute for the next 10 years.
2011.03.25 View 13635
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Cho Cheon Shik Graduate School of Green Transportation Initiated
KAIST established the Graduate School of Green Transportation in efforts to participate actively in the green transportation market and train experts in the field.
The opening ceremony was conducted in the KI building with President of KAIST Seo Nam Pyo and other dignitaries from Ministry of Land, Transport and Maritime Affairs, Korea Rail Network Authority, Korea Airports Corporation, Korea Railroad Research Institute, Land, Transport and Maritime Experts Training Institute, Seoul Development Institute, LG Innotech, Hyundai Rotem, and other major companies in the field of transportation attending.
The graduate school was founded with funding from donation made by Chairman Cho Cheon Shik. Developer of OLEV Professor Cho Dong Ho is the dean of the school and 16 other professors are a part of the school.
Courses offered include ‘Transportation Technology’ and ‘Transportation management’ and will focus mostly on allowing students to be a part of the graduate school with flexibility.
In terms of research there is the OLEV and mobile harbor and research will be done on electric and electronics, mechanics, materials, aeronautics, maritime, construction, environment, and etc. and will be an interdisciplinary research.
A memorandum of understanding was signed by the companies mentioned above which has now paved the way for experts to be trained and thus upgrade the level of technology in the field of green transportation.
Professor Seo of KAIST commented, ‘Korea is ranked top 10 in the world for greenhouse gas emissions and it has become hard to avoid global pressure. The results of researched performed at KAIST will allow Korea to form a green, sustainable society leading in the field of green transportation and dominate the market.
2011.02.23 View 18250
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Interdisciplinary Research on World Environmental Problems with Humanities
KAIST’s Professor Michael Pak (department of Humanities and Social Sciences) has published a paper in ‘Environmental Science and Technology, ES&T’ and was made Lead Feature.
His was the only paper published with a humanities background and his topic of discussion was ‘Environmentalism Then and Now: From Fears to Opportunities, 1970-2010’ in which he discussed the history of pro-environment activities, the patterns it showed, and its outlook.
Professor Park noted that the problems and concerns over the environment is not a recent phenomenon. It took over 50 years for the environmental problems to resurface after being the ‘hot issue’ of the time during the industrial revolution in the 19th century.
Professor Park deduced that there is a clear historical pattern.
Professor Park insisted that the two areas of Environmental Research ‘Global Warming’ and ‘Change in Weather’. Especially because these two areas are rife with uncertainty as it is, and making policies based on inaccurate information is taking a gamble.
Professor Park majored in history in UC Berkeley, received his masters’ and doctorate at Harvard University and was the professor at Massachusetts College of Art and Design before coming to KAIST at 2008.
2011.02.23 View 12448
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New Korean Robot Responds to Non-Verbal Commands
An online newspaper covering the latest headline news based on MS Windows, Internet and technology trends, Infopackets, posted an article on the research result of KAIST researchers: a robot prototype developed, which is able to respond to human’s non verbal communication.
Robots now can read human gestures and react to their subtle commands by “designing the robot’s main system to mimic the actions of a human in the same manner in which human brains function.” For details of the article, please click the link:
http://www.infopackets.com/news/technology/science/2011/20110125_new_korean_robot_responds_to_non_verbal_commands.htm
2011.01.26 View 10004
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Explanation for the polymerized nucleic acid enzyme's abnormal activation found
KAIST’s Professor Park Hyun Kyu of the Department of Bio Chemical Engineering revealed on the 23rd of December 2010 that his team had successfully developed the technology that uses the metal ions to control the abnormal activation of nucleic acids’ enzymes and using this, created a logic gate, which is a core technology in the field of future bio electrons.
The polymerized nucleic acid enzyme works to increase the synthesis of DNA and kicks into action only when the target DNA and primers form complimentary pairs (A and T, C and G).
Professor Park broke the common conception and found that it is possible for none complimentary pairs like T-T and C-C to initiate the activation of the enzyme and thus increase the nucleic acid production, given that there are certain metal ions present.
What Professor Park realized is that the enzymes mistake the uncomplimentary T-T and C-C pairs (with stabilized structures due to the bonding with mercury and silver ions) as being complimentary base pairs. Professor Park described this phenomenon as the “illusionary polymerase activity.”
The research team developed a logic gate based on the “illusionary polymerase activity’ phenomenon.” The logic gate paves the way to the development of future bio electron needed for bio computers and high performance memories.
Professor Park commented, “The research is an advancement of the previous research carried on about metal ions and nucleic acid synthesis. Our research is the first attempt at merging the concepts of the two previously separately carried out researches and can be adapted for testing presence of metal ions and development of a new single nucleotide polymorphic gene analysis technology.”
Professor Park added that, “Our research is a great stride in the field of nano scale electron element research as the results made possible the formation of accurate logic gates through relatively cost efficient and simple system designs.”
On a side note, the research was funded by Korea Research Foundation (Chairman: Park Chan Mo) and was selected as the cover paper for the December issue of ‘Angewandte Chemie International Edition’.
2011.01.18 View 12944 -
Professor Young-Ho Cho elected as head of international academic conference
KAIST’s Professor Young-Ho Cho of the Department of Bio and Brain Engineering was appointed as the head of the PowerMems (Power Micro Electro Mechanical Systems) symposium to be held at Se-Jong Hotel in Seoul from November 15-18, 2011.
Professor Jo is America’s first engineering doctor in the field of MEMS and is the founding member of the BSAC (Berkeley Sensor and Actuator Center), the start of the MEMS technology.
PowerMEMS is the core of green growth and next generation energy production. It focuses on harvesting energy from minute vibrations or renewable energy sources such as sunlight or plants to harvest and store energy via micro or even nano size systems.
The symposium was first held in 2000, and it is where leading experts in the field share papers on the production and harvesting energy in the micro scale.
2011.01.14 View 12387 -
Rise of the mimic-bots that act like we do: Human-machine teamwork.
An online magazine, Technology Marketing Corporation, based in the UK published an article, dated January 8, 2011, on a robot research project led by Professor Jong-Hwan Kim from the Electrical Engineering Department. The article follows below:
Technology Marketing Corporation
[January 08, 2011]
Rise of the mimic-bots that act like we do Human-machine teamwork
(New Scientist Via Acquire Media NewsEdge) Rise of the mimic-bots that act like we doA robot inspired by human mirror neurons can interpret human gestures to learn how it should actNow follow meA robot inspired by human mirror neurons can interpret human gestures to learn how it should actA HUMAN and a robot face each other across the room. The human picks up a ball, tosses it towards the robot, and then pushes a toy car in the same direction.
Confused by two objects coming towards it at the same time, the robot flashes a question mark on a screen. Without speaking, the human makes a throwing gesture. The robot turns its attention to the ball and decides to throw it back.
In this case the robot"s actions were represented by software commands, but it will be only a small step to adapt the system to enable a real robot to infer a human"s wishes from their gestures.
Developed by Ji-Hyeong Han and Jong-Hwan Kim at the Korea Advanced Institute of Science and Technology (KAIST) in Daejeon, the system is designed to respond to the actions of the person confronting it in the same way that our own brains do. The human brain contains specialised cells, called mirror neurons, that appear to fire in the same way when we watch an action being performed by others as they do when we perform the action ourselves. It is thought that this helps us to recognise or predict their intentions.
To perform the same feat, the robot observes what the person is doing, breaks the action down into a simple verbal description, and stores it in its memory. It compares the action it observes with a database of its own actions, and generates a simulation based on the closest match.
The robot also builds up a set of intentions or goals associated with an action. For example, a throwing gesture indicates that the human wants the robot to throw something back. The robot then connects the action "throw" with the object "ball" and adds this to its store of knowledge.
When the memory bank contains two possible intentions that fit the available information, the robot considers them both and determines which results in the most positive feedback from the human?- a smile or a nod, for example. If the robot is confused by conflicting information, it can request another gesture from the human. It also remembers details of each interaction, allowing it to respond more quickly when it finds itself in a situation it has encountered before.
The system should allow robots to interact more effectively with humans, using the same visual cues we use. "Of course, robots can recognise human intentions by understanding speech, but humans would have to make constant, explicit commands to the robot," says Han. "That would be pretty uncomfortable."Socially intelligent robots that can communicate with us through gesture and expression will need to develop a mental model of the person they are dealing with in order to understand their needs, says Chris Melhuish, director of the Bristol Robotics Laboratory in the UK. Using mirror neurons and humans" unique mimicking ability as an inspiration for building such robots could be quite interesting, he says.
Han now plans to test the system on a robot equipped with visual and other sensors to detect people"s gestures. He presented his work at the Robio conference in Tianjin, China, in December. nAs the population of many countries ages, elderly people may share more of their workload with robotic helpers or colleagues. In an effort to make such interactions as easy as possible, Chris Melhuish and colleagues at the Bristol Robotics Laboratory in the UK are leading a Europe-wide collaboration called Cooperative Human Robotic Interaction Systems that is equipping robots with software that recognises an object they are picking up before they hand it to a person. They also have eye-tracking technology that they use to monitor what humans are paying attention to. The goal is to develop robots that can learn to safely perform shared tasks with people, such as stirring a cake mixture as a human adds milk.
(c) 2011 Reed Business Information - UK. All Rights Reserved.
2011.01.10 View 11757
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International Workshop on EEWS 2010 was held.
On October 7 and 8th at Fusion Hall of KI Building, KAIST, the 2010 International Workshop on EEWS (Energy, Environment, Water, and Sustainability) was held.
The third to be held, forty national and international academic professionals including Mark Shannon, professor at University of Illinois at Urbana-Champaign, Domen Kazunari, Tokyo University professor, Dong Sub Kim, CTO of SK Energy and Doyoung Seung, Senior Vice President of GS Caltex, participated at this year’s workshop.
In twelve sessions, themes including Artificial Photosynthesis, Wireless Power Transfer, Green Aviation, Safe Nuclear Fuel Reuse, Fuel Cells in Action, LED 2.0, Foundation of Energy-Water Nexus, and Flexible Battery & Solar Cell were presented and discussed.
“Through this workshop, current EEWS policy and research progress from different countries and the future of related technologies will be foreseen,” said Jae Kyu Lee, Dean of KAIST EEWS Initiative. “I hope it became an opportunity to create cooperative relationships with leading researchers.”
EEWS is a research project conducted by KAIST to solve global issues that mankind faces today such as depletion of energy, environmental pollution, water shortage, and sustainability.
2010.10.15 View 18432
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Reasons for Hope: Jane Goodall Lectured at KAIST
Dr. Jane Goodall, globally acknowledged chimpanzee researcher and environmental activist, was invited to KAIST and gave a lecture on the importance of preservation and restoration of the ecosystem on the earth. The lecture took place on the 28 of September at the university’s auditorium from 5PM to 7PM.
The lecture, titled “Reasons for Hope: Celebrating 50 Years of Chimpanzee Research,” was organized to celebrate her longtime career as a primatologist and anthropologist.
The visiting of Dr. Jane Goodall, who had dedicated a long period of time in spreading the significance of the diversity of life, gave a meaningful opportunity to increase the Korean public’s awareness of life’s diversity.
This lecture was jointly sponsored by Ehwa Woman’s University and KAIST, and the lecture was translated by Professor Choi Jae-Chun of Ehwa University.
2010.09.29 View 10371 -
An internationally renowned academic journal published the research result produced by a KAST research team on its cover.
Fc DAAP VEGF-Trap
Photograph showing the gross features of tumor growth along the mesentery-intestinal border. T: tumor. Scale bars represent 5 mm.
Professor Gou-Young Koh of the Biological Sciences Department, KAIST, and his research team published their research result in Cancer Cell, a peer-review scientific journal, as a cover article dated August 17, 2010. It is the first time for the journal to pick up a paper written by a Korean research team and publish it as the cover.
It has been known that a vascular growth factor (VEGF) is closely related to the growth of a tumor. The research team recently discovered that in addition to VEGF, another growth factor, angiopoietin-2 (Ang2), is also engaged with the increase of tumors.
Professor Koh said, “VEGF and the angiopoietins play critical roles in tumor progression and metastasis, and a single inhibitor targeting both factors have not been available.”
The team led by Professor Koh has developed a double anti-angiogenic protein (DAAP) that can simultaneously bind VEGF-A and the angiopoietins and block their actions.
Professor Koh said in his paper, “DAAP is a highly effective molecule for regressing tumor angiogenesis and metastasis in implanted and spontaneous solid tumor; it can also effectively reduce ascites formation and vascular leakage in an ovarian carcinoma model. Thus, simultaneous blockade of VEGF-A and angiopoietins with DAAP is an effective therapeutic strategy for blocking tumor angiogenesis, metastasis, and vascular leakage.”
So far, cancer patients have received Avastin, anticancer drug, to inhibit VEGF, but the drug has not successfully restrained the growth of cancer tumors and brought to some of the patients with serious side effects instead.
Professor Koh said, “DAAP will be very effective to control the expansion of tumor growth factors, which will open up a new possibility for the development of more helpful cancer medicine with low side effects.”
2010.08.20 View 13542