LLO
-
SM CEP Soo-Man Lee to Teach at the KAIST School of Computing
The Founder and Chief Executive Producer of SM Entertainment Soo-Man Lee was appointed as a distinguished visiting professor in the KAIST School of Computing. His three-year term starts on March 1.
KAIST and the SM Entertainment signed an MOU on joint research on the metaverse last year and Lee’s appointment is the extension of their mutual collaborations in fields where technologies converge and will encourage innovative advancements in engineering technology and the entertainment industry.
Lee, who completed a graduate program in computer science at California State University Northridge will give special leadership lectures for both undergraduate and graduate students, and will participate in metaverse-related research as a consultant.
In particular, Professor Lee will participate in joint research with the tentatively named Metaverse Institute affiliated with the KAIST Institute for Artificial Intelligence. The institute will help SM Entertainment stay ahead of the global metaverse market by using the avatars of celebrities, and lend itself to raising the already strong brand power of the K-pop leader.
Professor Lee said, “I am grateful that KAIST, the very cradle of Korea’s science and technology, has given me the opportunity to meet its students as a visiting professor. We will lead the metaverse world, in which Korea is emerging as a market leader, with the excellent contents and technology unique to our country, and work together to lead the future global entertainment market.”
President Kwang-Hyung Lee said, “The ability to expand our limitless creativity in the metaverse is indispensable for us as we adapt to this new era. We hope that the vision and creative insights of Executive Producer Lee, which have allowed him to look ahead into the future of the entertainment contents market, will have a positive and fresh impact on the members of KAIST.”
The global influence and reputation of Executive Producer Lee has been well established through his various awards. He was the first Korean to be listed on Variety500 for five consecutive years from 2017 to 2021. He was also the first Korean awardee of the Asia Game Changer Awards in 2016, the first cultural figure to receive the YoungSan Diplomacy Award in 2017, the only Korean to be listed on the 2020 Billboard Impact List, and he has also received the K-pop Contribution Award at the 10th Gaon Chart Music Awards. He recently introduced Play2Create (P2C), a new interactive and creative culture in which re-creation can be enjoyed like a game using IP, and is leading the establishment of the P2C ecosystem.
2022.03.03 View 5964 -
Scientist Discover How Circadian Rhythm Can Be Both Strong and Flexible
Study reveals that master and slave oscillators function via different molecular mechanisms
From tiny fruit flies to human beings, all animals on Earth maintain their daily rhythms based on their internal circadian clock. The circadian clock enables organisms to undergo rhythmic changes in behavior and physiology based on a 24-hour circadian cycle. For example, our own biological clock tells our brain to release melatonin, a sleep-inducing hormone, at night time.
The discovery of the molecular mechanism of the circadian clock was bestowed the Nobel Prize in Physiology or Medicine 2017. From what we know, no one centralized clock is responsible for our circadian cycles. Instead, it operates in a hierarchical network where there are “master pacemaker” and “slave oscillator”.
The master pacemaker receives various input signals from the environment such as light. The master then drives the slave oscillator that regulates various outputs such as sleep, feeding, and metabolism. Despite the different roles of the pacemaker neurons, they are known to share common molecular mechanisms that are well conserved in all lifeforms. For example, interlocked systems of multiple transcriptional-translational feedback loops (TTFLs) composed of core clock proteins have been deeply studied in fruit flies.
However, there is still much that we need to learn about our own biological clock. The hierarchically-organized nature of master and slave clock neurons leads to a prevailing belief that they share an identical molecular clockwork. At the same time, the different roles they serve in regulating bodily rhythms also raise the question of whether they might function under different molecular clockworks.
Research team led by Professor Kim Jae Kyoung from the Department of Mathematical Sciences, a chief investigator at the Biomedical Mathematics Group at the Institute for Basic Science, used a combination of mathematical and experimental approaches using fruit flies to answer this question. The team found that the master clock and the slave clock operate via different molecular mechanisms.
In both master and slave neurons of fruit flies, a circadian rhythm-related protein called PER is produced and degraded at different rates depending on the time of the day. Previously, the team found that the master clock neuron (sLNvs) and the slave clock neuron (DN1ps) have different profiles of PER in wild-type and Clk-Δ mutant Drosophila. This hinted that there might be a potential difference in molecular clockworks between the master and slave clock neurons.
However, due to the complexity of the molecular clockwork, it was challenging to identify the source of such differences. Thus, the team developed a mathematical model describing the molecular clockworks of the master and slave clocks. Then, all possible molecular differences between the master and slave clock neurons were systematically investigated by using computer simulations. The model predicted that PER is more efficiently produced and then rapidly degraded in the master clock compared to the slave clock neurons. This prediction was then confirmed by the follow-up experiments using animal.
Then, why do the master clock neurons have such different molecular properties from the slave clock neurons? To answer this question, the research team again used the combination of mathematical model simulation and experiments. It was found that the faster rate of synthesis of PER in the master clock neurons allows them to generate synchronized rhythms with a high level of amplitude. Generation of such a strong rhythm with high amplitude is critical to delivering clear signals to slave clock neurons.
However, such strong rhythms would typically be unfavorable when it comes to adapting to environmental changes. These include natural causes such as different daylight hours across summer and winter seasons, up to more extreme artificial cases such as jet lag that occurs after international travel. Thanks to the distinct property of the master clock neurons, it is able to undergo phase dispersion when the standard light-dark cycle is disrupted, drastically reducing the level of PER. The master clock neurons can then easily adapt to the new diurnal cycle. Our master pacemaker’s plasticity explains how we can quickly adjust to the new time zones after international flights after just a brief period of jet lag.
It is hoped that the findings of this study can have future clinical implications when it comes to treating various disorders that affect our circadian rhythm. Professor Kim notes, “When the circadian clock loses its robustness and flexibility, the circadian rhythms sleep disorders can occur. As this study identifies the molecular mechanism that generates robustness and flexibility of the circadian clock, it can facilitate the identification of the cause of and treatment strategy for the circadian rhythm sleep disorders.” This work was supported by the Human Frontier Science Program.
-PublicationEui Min Jeong, Miri Kwon, Eunjoo Cho, Sang Hyuk Lee, Hyun Kim, Eun Young Kim, and Jae Kyoung Kim, “Systematic modeling-driven experiments identify distinct molecularclockworks underlying hierarchically organized pacemaker neurons,” February 22, 2022, Proceedings of the National Academy of Sciences of the United States of America
-ProfileProfessor Jae Kyoung KimDepartment of Mathematical SciencesKAIST
2022.02.23 View 9422 -
Research Finds Digital Music Streaming Consumption Dropped as a Result of Covid-19 and Lockdowns
Decline in human mobility has stunning consequences for content streaming
The Covid-19 pandemic and lockdowns significantly reduced the consumption of audio music streaming in many countries as people turned to video platforms. On average, audio music consumption decreased by 12.5% after the World Health Organization’s (WHO) pandemic declaration in March 2020.
Music streaming services were an unlikely area hit hard by the Covid-19 pandemic. New research in Marketing Science found that the drop in people’s mobility during the pandemic significantly reduced the consumption of audio music streaming. Instead, people turned more to video platforms.
“On average, audio music consumption decreased by more than 12% after the World Health Organization’s (WHO) pandemic declaration on March 11, 2020. As a result, during the pandemic, Spotify lost 838 million dollars of revenue in the first three quarters of 2020,” said Jaeung Sim, a PhD candidate in management engineering at KAIST and one of the authors of the research study on this phenomenon. “Our results showed that human mobility plays a much larger role in the audio consumption of music than previously thought.”
The study, “Frontiers: Virus Shook the Streaming Star: Estimating the Covid-19 Impact on Music Consumption,” conducted by Sim and Professor Daegon Cho of KAIST, Youngdeok Hwang of City University of New York, and Rahul Telang of Carnegie Mellon University, looked at online music streaming data for top songs for two years in 60 countries, as well as Covid-19 cases, lockdown statistics, and daily mobility data, to determine the nature of the changes.
The study showed how the pandemic adversely impacted music streaming services despite the common expectation that the pandemic would universally benefit online medias platforms. This implies that the substantially changing media consumption environment can place streaming music in fiercer competition with other media forms that offer more dynamic and vivid experiences to consumers.
The researchers found that music consumption through video platforms was positively associated with the severity of Covid-19, lockdown policies, and time spent at home.
-PublicationJaeung Sim, Daegon Cho, Youngdeok Hwang, and Rahul Telang,“Frontiers: Virus Shook the Streaming Star: Estimating the Covid-19 Impact on Music Consumption,” November 30 in Marketing Science online (doi.org/10.1287/mksc.2021.1321)
-Profile Professor Daegon ChoGraduate School of Information and Media ManagementCollege of BusinessKAIST
2022.02.15 View 9478 -
Label-Free Multiplexed Microtomography of Endogenous Subcellular Dynamics Using Deep Learning
AI-based holographic microscopy allows molecular imaging without introducing exogenous labeling agents
A research team upgraded the 3D microtomography observing dynamics of label-free live cells in multiplexed fluorescence imaging. The AI-powered 3D holotomographic microscopy extracts various molecular information from live unlabeled biological cells in real time without exogenous labeling or staining agents.
Professor YongKeum Park’s team and the startup Tomocube encoded 3D refractive index tomograms using the refractive index as a means of measurement. Then they decoded the information with a deep learning-based model that infers multiple 3D fluorescence tomograms from the refractive index measurements of the corresponding subcellular targets, thereby achieving multiplexed micro tomography. This study was reported in Nature Cell Biology online on December 7, 2021.
Fluorescence microscopy is the most widely used optical microscopy technique due to its high biochemical specificity. However, it needs to genetically manipulate or to stain cells with fluorescent labels in order to express fluorescent proteins. These labeling processes inevitably affect the intrinsic physiology of cells. It also has challenges in long-term measuring due to photobleaching and phototoxicity. The overlapped spectra of multiplexed fluorescence signals also hinder the viewing of various structures at the same time. More critically, it took several hours to observe the cells after preparing them.
3D holographic microscopy, also known as holotomography, is providing new ways to quantitatively image live cells without pretreatments such as staining. Holotomography can accurately and quickly measure the morphological and structural information of cells, but only provides limited biochemical and molecular information.
The 'AI microscope' created in this process takes advantage of the features of both holographic microscopy and fluorescence microscopy. That is, a specific image from a fluorescence microscope can be obtained without a fluorescent label. Therefore, the microscope can observe many types of cellular structures in their natural state in 3D and at the same time as fast as one millisecond, and long-term measurements over several days are also possible.
The Tomocube-KAIST team showed that fluorescence images can be directly and precisely predicted from holotomographic images in various cells and conditions. Using the quantitative relationship between the spatial distribution of the refractive index found by AI and the major structures in cells, it was possible to decipher the spatial distribution of the refractive index. And surprisingly, it confirmed that this relationship is constant regardless of cell type.
Professor Park said, “We were able to develop a new concept microscope that combines the advantages of several microscopes with the multidisciplinary research of AI, optics, and biology. It will be immediately applicable for new types of cells not included in the existing data and is expected to be widely applicable for various biological and medical research.”
When comparing the molecular image information extracted by AI with the molecular image information physically obtained by fluorescence staining in 3D space, it showed a 97% or more conformity, which is a level that is difficult to distinguish with the naked eye.
“Compared to the sub-60% accuracy of the fluorescence information extracted from the model developed by the Google AI team, it showed significantly higher performance,” Professor Park added.
This work was supported by the KAIST Up program, the BK21+ program, Tomocube, the National Research Foundation of Korea, and the Ministry of Science and ICT, and the Ministry of Health & Welfare.
-Publication
Hyun-seok Min, Won-Do Heo, YongKeun Park, et al. “Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning,” Nature Cell Biology (doi.org/10.1038/s41556-021-00802-x) published online December 07 2021.
-Profile
Professor YongKeun Park
Biomedical Optics Laboratory
Department of Physics
KAIST
2022.02.09 View 10516 -
AI Light-Field Camera Reads 3D Facial Expressions
Machine-learned, light-field camera reads facial expressions from high-contrast illumination invariant 3D facial images
A joint research team led by Professors Ki-Hun Jeong and Doheon Lee from the KAIST Department of Bio and Brain Engineering reported the development of a technique for facial expression detection by merging near-infrared light-field camera techniques with artificial intelligence (AI) technology.
Unlike a conventional camera, the light-field camera contains micro-lens arrays in front of the image sensor, which makes the camera small enough to fit into a smart phone, while allowing it to acquire the spatial and directional information of the light with a single shot. The technique has received attention as it can reconstruct images in a variety of ways including multi-views, refocusing, and 3D image acquisition, giving rise to many potential applications.
However, the optical crosstalk between shadows caused by external light sources in the environment and the micro-lens has limited existing light-field cameras from being able to provide accurate image contrast and 3D reconstruction.
The joint research team applied a vertical-cavity surface-emitting laser (VCSEL) in the near-IR range to stabilize the accuracy of 3D image reconstruction that previously depended on environmental light. When an external light source is shone on a face at 0-, 30-, and 60-degree angles, the light field camera reduces 54% of image reconstruction errors. Additionally, by inserting a light-absorbing layer for visible and near-IR wavelengths between the micro-lens arrays, the team could minimize optical crosstalk while increasing the image contrast by 2.1 times.
Through this technique, the team could overcome the limitations of existing light-field cameras and was able to develop their NIR-based light-field camera (NIR-LFC), optimized for the 3D image reconstruction of facial expressions. Using the NIR-LFC, the team acquired high-quality 3D reconstruction images of facial expressions expressing various emotions regardless of the lighting conditions of the surrounding environment.
The facial expressions in the acquired 3D images were distinguished through machine learning with an average of 85% accuracy – a statistically significant figure compared to when 2D images were used. Furthermore, by calculating the interdependency of distance information that varies with facial expression in 3D images, the team could identify the information a light-field camera utilizes to distinguish human expressions.
Professor Ki-Hun Jeong said, “The sub-miniature light-field camera developed by the research team has the potential to become the new platform to quantitatively analyze the facial expressions and emotions of humans.” To highlight the significance of this research, he added, “It could be applied in various fields including mobile healthcare, field diagnosis, social cognition, and human-machine interactions.”
This research was published in Advanced Intelligent Systems online on December 16, under the title, “Machine-Learned Light-field Camera that Reads Facial Expression from High-Contrast and Illumination Invariant 3D Facial Images.” This research was funded by the Ministry of Science and ICT and the Ministry of Trade, Industry and Energy.
-Publication“Machine-learned light-field camera that reads fascial expression from high-contrast and illumination invariant 3D facial images,” Sang-In Bae, Sangyeon Lee, Jae-Myeong Kwon, Hyun-Kyung Kim. Kyung-Won Jang, Doheon Lee, Ki-Hun Jeong, Advanced Intelligent Systems, December 16, 2021 (doi.org/10.1002/aisy.202100182)
ProfileProfessor Ki-Hun JeongBiophotonic LaboratoryDepartment of Bio and Brain EngineeringKAIST
Professor Doheon LeeDepartment of Bio and Brain EngineeringKAIST
2022.01.21 View 12120 -
Seven Faculty Members Elected to Join the National Academy of Engineering of Korea
< Clockwise from top left: Professor Doo-Hwan Bae, Professor Seung Seob Lee, Professor Kyung Cheol Choi, Professor JaeYong Choung >
Seven KAIST faculty members have been elected as National Academy of Engineering of Korea (NAEK) members and associate members. NAEK, the most prestigious engineering society in Korea, elects new members with a minimum of 15 years of experience in engineering in academia and business every year.
In 2022, 24 members were newly elected from academia, including four KAIST faculty members: Professor Doo-Hwan Bae from the SW Education Center, KAIST Provost and Executive Vice President Seung Seob Lee, Professor JaeYong Choung from the School of Business and Technology Management, and Professor Kyung Cheol Choi of the School of Electrical Engineering. In the business sector, 21 members were elected as members in business, including Vice Chairman Jong-hee Han of Samsung Electronics, CEO Hyeon-Mo Ku of KT, President Sang-Ryul Lee of the Korea Aerospace Research Institute, President Kyo Won Jin of SK Hynix, CEO Eunkang Song of Capstone Partners, and Executive Vice President Se-hoon Kim of Hyundai Motor Company.
Among the newly elected 40 associate members from academia, three KAIST professors were listed: Professor Sukyoung Ryu from the School of Computing, Professor Joongmyeon Bae from the Department of Mechanical Engineering, and Professor EunAe Cho from the Department of Materials Science and Engineering. Another 44 members were elected as associate members in business, including Vice Chairman Hag-Dong Kim of POSCO, President Seong-Hyeon Cho of Mando Corp, President Siyoung Choi of Samsung Electronics, President Joo Sun Choi of Samsung Display, and Chairman Byung-Gyu Chang of Krafton.
NAEK evaluates candidates not only on their academic achievements, but on various other criteria including technological achievements, patents, the nurturing of talents, and contributions to the advancements of the industry. Candidates are then elected through written ballots by the members of NAEK. There are now 294 members and 360 associate members of NAEK.
2022.01.14 View 6307 -
Perigee-KAIST Rocket Research Center Launches Scientific Rocket
Undergraduate startup Perigree Aerospace develops suborbital rocket called Blue Whale 0.1
On December 29, Perigee Aerospace, an undergraduate startup, launched a test rocket with a length of 3.2 m, a diameter of 19 cm, and a weight of 51 kg, using ethanol and liquid oxygen as fuel. The launch took place off Jeju Island. It was aimed at building experience and checking the combustion of a liquid propulsion engine and the performance of pre-set flight and trajectory, communication, and navigation devices. It was also one of the projects marking the 50th anniversary of KAIST in 2021.
However, after flying for several seconds, the rocket lost its track due to a gust of wind that activated the rocket’s automatic flight suspension system. "At the moment the rocket took off, there was a much stronger gust than expected," Dong-Yoon Shin, CEO of Perigee said. "The wind sent it flying off course and the automatic flight suspension system stopped its engine." However, Shin was not disappointed, saying the launch, which was conducted in collaboration with Perigee-KAIST Rocket Research Center provided a good experience.
"Some people say that Blue Whale 0.1 is like a toy because of its small size. Of course, it's much smaller than the rockets I’ve dreamed of, but like other rockets, it has all the technology needed for launch," said Shin, who established his company in 2018 as a KAIST aerospace engineering student to develop small liquid-propellant orbital rockets. Perigee Aerospace aims to develop the world’s lightest launch vehicle using high-powered engines, with a goal of leading the global market for small launch vehicles in the new space generation.
Perigee-KAIST Rocket Research Center was founded in 2019 for the research and development of rocket propellants and has been testing the combustion of rocket engines of various sizes in their liquid propellant rocket combustion lab located on the KAIST Munji Campus.
The research center initiated the 50th anniversary rocket launch project in late April of last year, finished the examination of their preliminary design in late May, and secured a tentative launching site through the KAIST-Jejudo agreement in early July.
The ethanol engine combustion was tested in late July, and an examination meeting regarding the detailed design that took place in late August was followed by two months of static firing tests of the assembled rocket in October and November.
This was a very meaningful trial in which a domestic private enterprise founded by a college student collaborated with a university to successfully develop and launch a technically challenging liquid propellant rocket.
Shin's near-term goal is to launch a two-stage orbital rocket that uses liquid methane as fuel and weighs 1.8 tons. To secure competitiveness in the small projectile market, KAIST and Perigee Aerospace have set up a joint research center to test various rocket engine sizes and develop the world's lightest projectile using a high-performance engine.
Professor Jae-Hung Han, head of the Department of Aerospace Engineering, said, “The scientific rocket system secured through the launch of the celebratory rocket will be utilized for design and system-oriented education, and for carrying out various scientific missions.” He added, “It is very rare both domestically and globally that a scientific rocket designed by the initiatives of a department should be incorporated as part of a regular aerospace system design curriculum. This will be an exemplary case we can boast about to the rest of the world.”
Perigee Aerospace will improve the technology they have developed through the course of this project to develop subminiature vehicles they may use to launch small satellites into the low Earth orbit.
Shin said, “I am happy just with the fact that we have participated in a rocket project to celebrate the 50th anniversary of KAIST, and I would like to thank the engineers at my company and members of the KAIST Department of Aerospace Engineering.” He added, “I’m looking forward to the day that we develop a space launch vehicle that can deliver satellites even higher.”
2022.01.14 View 8609 -
AI Weather Forecasting Research Center Opens
The Kim Jaechul Graduate School of AI in collaboration with the National Institute of Meteorological Sciences (NIMS) under the National Meteorological Administration launched the AI Weather Forecasting Research Center last month.
The KAIST AI Weather Forecasting Research Center headed by Professor Seyoung Yoon was established with funding from from the AlphaWeather Development Research Project of the National Institute of Meteorological Sciences. KAIST was finally selected asas the project facilitator.
AlphaWeather is an AI system that utilizes and analyzes approximately approximately 150,000 ,000 pieces of weather information per hour to help weather forecasters produce accurate weather forecasts. The research center is composed of three research teams with the following goals: (a) developdevelop AI technology for precipitation nowcasting, (b) developdevelop AI technology for accelerating physical process-based numerical models, and (c) develop dAI technology for supporting weather forecasters. The teams consist of 15 staff member members from NIMS and 61 researchers from the Kim Jaechul Graduate School of AI at KAIST.
The research center is developing an AI algorithm for precipitation nowcasting (with up to six hours of lead time), which uses satellite images, radar reflectivity, and data collected from weather stations. It is also developing an AI algorithm for correcting biases in the prediction results from multiple numerical models. Finally, it is Finally, it is developing AI technology that supports weather forecasters by standardizing and automating repetitive manual processes. After verification, the the results obtained will be used by by the Korean National Weather Service as a next-generation forecasting/special-reporting system intelligence engine from 2026.
2022.01.10 View 6111 -
Team KAIST to Race at CES 2022 Autonomous Challenge
Five top university autonomous racing teams will compete in a head-to-head passing competition in Las Vegas
A self-driving racing team from the KAIST Unmanned System Research Group (USRG) advised by Professor Hyunchul Shim will compete at the Autonomous Challenge at the Consumer Electronic Show (CES) on January 7, 2022. The head-to-head, high speed autonomous racecar passing competition at the Las Vegas Motor Speedway will feature the finalists and semifinalists from the Indy Autonomous Challenge in October of this year. Team KAIST qualified as a semifinalist at the Indy Autonomous Challenge and will join four other university teams including the winner of the competition, Technische Universität München.
Team KAIST’s AV-21 vehicle is capable of driving on its own at more than 200km/h will be expected to show a speed of more than 300 km/h at the race.The participating teams are:1. KAIST2. EuroRacing : University of Modena and Reggio Emilia (Italy), University of Pisa (Italy), ETH Zürich (Switzerland), Polish Academy of Sciences (Poland) 3. MIT-PITT-RW, Massachusetts Institute of Technology, University of Pittsburgh, Rochester Institute of Technology, University of Waterloo (Canada)4.PoliMOVE – Politecnico di Milano (Italy), University of Alabama 5.TUM Autonomous Motorsport – Technische Universität München (Germany)
Professor Shim’s team is dedicated to the development and validation of cutting edge technologies for highly autonomous vehicles. In recognition of his pioneering research in unmanned system technologies, Professor Shim was honored with the Grand Prize of the Minister of Science and ICT on December 9.
“We began autonomous vehicle research in 2009 when we signed up for Hyundai Motor Company’s Autonomous Driving Challenge. For this, we developed a complete set of in-house technologies such as low-level vehicle control, perception, localization, and decision making.” In 2019, the team came in third place in the Challenge and they finally won this year.
For years, his team has participated in many unmanned systems challenges at home and abroad, gaining recognition around the world. The team won the inaugural 2016 IROS autonomous drone racing and placed second in the 2018 IROS Autonomous Drone Racing Competition. They also competed in 2017 MBZIRC, ranking fourth in Missions 2 and 3, and fifth in the Grand Challenge.
Most recently, the team won the first round of Lockheed Martin’s Alpha Pilot AI Drone Innovation Challenge. The team is now participating in the DARPA Subterranean Challenge as a member of Team CoSTAR with NASA JPL, MIT, and Caltech.
“We have accumulated plenty of first-hand experience developing autonomous vehicles with the support of domestic companies such as Hyundai Motor Company, Samsung, LG, and NAVER. In 2017, the autonomous vehicle platform “EureCar” that we developed in-house was authorized by the Korean government to lawfully conduct autonomous driving experiment on public roads,” said Professor Shim.
The team has developed various key technologies and algorithms related to unmanned systems that can be categorized into three major components: perception, planning, and control. Considering the characteristics of the algorithms that make up each module, their technology operates using a distributed computing system.
Since 2015, the team has been actively using deep learning algorithms in the form of perception subsystems. Contextual information extracted from multi-modal sensory data gathered via cameras, lidar, radar, GPS, IMU, etc. is forwarded to the planning subsystem. The planning module is responsible for the decision making and planning required for autonomous driving such as lane change determination and trajectory planning, emergency stops, and velocity command generation. The results from the planner are fed into the controller to follow the planned high-level command. The team has also developed and verified the possibility of an end-to-end deep learning based autonomous driving approach that replaces a complex system with one single AI network.
2021.12.17 View 10660 -
A Study Shows Reactive Electrolyte Additives Improve Lithium Metal Battery Performance
Stable electrode-electrolyte interfaces constructed by fluorine- and nitrogen-donating ionic additives provide an opportunity to improve high-performance lithium metal batteries
A research team showed that electrolyte additives increase the lifetime of lithium metal batteries and remarkably improve the performance of fast charging and discharging. Professor Nam-Soon Choi’s team from the Department of Chemical and Biomolecular Engineering at KAIST hierarchized the solid electrolyte interphase to make a dual-layer structure and showed groundbreaking run times for lithium metal batteries.
The team applied two electrolyte additives that have different reduction and adsorption properties to improve the functionality of the dual-layer solid electrolyte interphase. In addition, the team has confirmed that the structural stability of the nickel-rich cathode was achieved through the formation of a thin protective layer on the cathode. This study was reported in Energy Storage Materials.
Securing high-energy-density lithium metal batteries with a long lifespan and fast charging performance is vital for realizing their ubiquitous use as superior power sources for electric vehicles. Lithium metal batteries comprise a lithium metal anode that delivers 10 times higher capacity than the graphite anodes in lithium-ion batteries. Therefore, lithium metal is an indispensable anode material for realizing high-energy rechargeable batteries. However, undesirable reactions among the electrolytes with lithium metal anodes can reduce the power and this remains an impediment to achieving a longer battery lifespan. Previous studies only focused on the formation of the solid electrolyte interphase on the surface of the lithium metal anode.
The team designed a way to create a dual-layer solid electrolyte interphase to resolve the instability of the lithium metal anode by using electrolyte additives, depending on their electron accepting ability and adsorption tendencies. This hierarchical structure of the solid electrolyte interphase on the lithium metal anode has the potential to be further applied to lithium-alloy anodes, lithium storage structures, and anode-free technology to meet market expectations for electrolyte technology.
The batteries with lithium metal anodes and nickel-rich cathodes represented 80.9% of the initial capacity after 600 cycles and achieved a high Coulombic efficiency of 99.94%. These remarkable results contributed to the development of protective dual-layer solid electrolyte interphase technology for lithium metal anodes.
Professor Choi said that the research suggests a new direction for the development of electrolyte additives to regulate the unstable lithium metal anode-electrolyte interface, the biggest hurdle in research on lithium metal batteries.
She added that anode-free secondary battery technology is expected to be a game changer in the secondary battery market and electrolyte additive technology will contribute to the enhancement of anode-free secondary batteries through the stabilization of lithium metal anodes.
This research was funded by the Technology Development Program to Solve Climate Change of the National Research Foundation in Korea funded by the Ministry of Science, ICT & Future Planning and the Technology Innovation Program funded by the Ministry of Trade, Industry & Energy, and Hyundai Motor Company.
- PublicationSaehun Kim, Sung O Park, Min-Young Lee, Jeong-A Lee, Imanuel Kristanto, Tae Kyung Lee, Daeyeon Hwang, Juyoung Kim, Tae-Ung Wi, Hyun-Wook Lee, Sang Kyu Kwak, and NamSoon Choi, “Stable electrode-electrolyte interfaces constructed by fluorine- and nitrogen-donating ionic additives for high-performance lithium metal batteries,” Energy Storage Materials,45, 1-13 (2022), (doi: https://doi.org/10.1016/j.ensm.2021.10.031)
- ProfileProfessor Nam-Soon ChoiEnergy Materials LaboratoryDepartment of Chemical and Biomolecular EngineeringKAIST
2021.12.16 View 9221 -
KAIST Plans to Open a New York Campus
President Lee signs an MOU with New York-based Big Continent Inc. Chairman Hee-Nam Bae on funding the New York campus
President Kwang Hyung Lee announced a plan to open a KAIST campus in New York with funding from New York-based entrepreneur Hee-Nam Bae. President Lee and Big Continent Inc. Chairman Hee-Nam Bae signed the MOU last week for the funding to open the campus in New York.
President Lee said it will take years to open up a campus in New York in order to conform with both Korean and US legal procedures. However, during a news conference in New York following the signing of the MOU with Chairman Bae, President Lee said this is the first step toward realizing KAIST’s new vision of a ‘Global Twin Strategy’ by making New York KAIST’s newest stronghold to target both domestic and global markets.
“New York is the center of the world’s commerce, culture, and new technologies. If we want to grow big, we should go to one of the biggest cities in the world and New York is the place. I highly encourage our students and faculty go into the world and never be satisfied enjoying the top position in Korea. The next place to investigate will be Silicon Valley,” said President Lee.
“We still have many issues to resolve domestically. We need to discuss more details first with the Board of Trustees and the Korean government,” he added.
The New York campus will aim to become an enterprise-type university to help KAIST create global value. "Our goal is to make sure that Korean businesses gain competitiveness in the global market and can become listed on the NASDAQ. We plan to open majors related to AI, financial engineering, and cultural technologies. We will recruit students from both the US and KAIST to study at our New York campus.” President Lee said.
Chairman Bae, a self-made entrepreneur who immigrated to the US in 1981, also leads the Global Leadership Foundation in the US. “President Lee and I have already toured several candidate sites for the campus in the New York region and we will make a final decision on the best site to purchase,” said Chairman Bae.
Chairman Bae added that he has always dreamed of fostering young global talents who will take on global challenges with pioneering minds. He believes KAIST shares this global vision.
The New York campus will be the first KAIST campus for global students funded by someone from the private sector. This is also a major step forward for KAIST, which was founded by a six million dollar USAID loan in 1971. KAIST announced its plans to establish Kenya KAIST in 2018 with funding from the Korea Eximbank’s 95 million USD development cooperation fund loan to the Kenyan government. KAIST will provide turn-key-based education consultancy featuring curriculum design and the construction of facilities for Kenya’s first advanced science and technology institute. The campus will be located in the Konza Techno City near Nairobi and plans to open in 2023.
2021.12.13 View 8597 -
Connecting the Dots to Find New Treatments for Breast Cancer
Systems biologists uncovered new ways of cancer cell reprogramming to treat drug-resistant cancers
Scientists at KAIST believe they may have found a way to reverse an aggressive, treatment-resistant type of breast cancer into a less dangerous kind that responds well to treatment. The study involved the use of mathematical models to untangle the complex genetic and molecular interactions that occur in the two types of breast cancer, but could be extended to find ways for treating many others. The study’s findings were published in the journal Cancer Research.
Basal-like tumours are the most aggressive type of breast cancer, with the worst prognosis. Chemotherapy is the only available treatment option, but patients experience high recurrence rates. On the other hand, luminal-A breast cancer responds well to drugs that specifically target a receptor on their cell surfaces, called estrogen receptor alpha (ERα).
KAIST systems biologist Kwang-Hyun Cho and colleagues analyzed the complex molecular and genetic interactions of basal-like and luminal-A breast cancers to find out if there might be a way to switch the former to the latter and give patients a better chance to respond to treatment.
To do this, they accessed large amounts of cancer and patient data to understand which genes and molecules are involved in the two types. They then input this data into a mathematical model that represents genes, proteins and molecules as dots and the interactions between them as lines. The model can be used to conduct simulations and see how interactions change when certain genes are turned on or off.
“There have been a tremendous number of studies trying to find therapeutic targets for treating basal-like breast cancer patients,” says Cho. “But clinical trials have failed due to the complex and dynamic nature of cancer. To overcome this issue, we looked at breast cancer cells as a complex network system and implemented a systems biological approach to unravel the underlying mechanisms that would allow us to reprogram basal-like into luminal-A breast cancer cells.”
Using this approach, followed by experimental validation on real breast cancer cells, the team found that turning off two key gene regulators, called BCL11A and HDAC1/2, switched a basal-like cancer signalling pathway into a different one used by luminal-A cancer cells. The switch reprograms the cancer cells and makes them more responsive to drugs that target ERα receptors. However, further tests will be needed to confirm that this also works in animal models and eventually humans.
“Our study demonstrates that the systems biological approach can be useful for identifying novel therapeutic targets,” says Cho.
The researchers are now expanding its breast cancer network model to include all breast cancer subtypes. Their ultimate aim is to identify more drug targets and to understand the mechanisms that could drive drug-resistant cells to turn into drug-sensitive ones.
This work was supported by the National Research Foundation of Korea, the Ministry of Science and ICT, Electronics and Telecommunications Research Institute, and the KAIST Grand Challenge 30 Project.
-Publication Sea R. Choi, Chae Young Hwang, Jonghoon Lee, and Kwang-Hyun Cho, “Network Analysis Identifies Regulators of Basal-like Breast Cancer Reprogramming and Endocrine TherapyVulnerability,” Cancer Research, November 30. (doi:10.1158/0008-5472.CAN-21-0621)
-ProfileProfessor Kwang-Hyun ChoLaboratory for Systems Biology and Bio-Inspired EngineeringDepartment of Bio and Brain EngineeringKAIST
2021.12.07 View 10265